| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Coexpression of a CD 4 antigen and plasma cell antigens ( CD 38 and PCA 1 ) was an unusual and sustained feature . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Reductions in the percentage of CD 4 and CD 8 lymphocytes expressing CD 38 were noted . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Lymphocytes expressing CD 4 , CD 8 , and CD 38 were equally represented in apoptotic and live populations . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Expression of CD 4 , CD 8 , CD 25 , CD 38 , L selectin , CD 44 , alphaEbeta 7 and alpha4beta7 were studied . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The immunophenotype showed the expression of CD 4 , CD 56 , CD 68 , CD 33 , CD 7 , CD 2 , CD45RA , and CD 38 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| A decrease in CD 38 expression in the absence of HLA DR changes was observed in CD 4 cells . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The monoclonal antibodies included CD 4 , CD 8 , CD 19 , CD 34 , CD 38 , CD 83 , CD1a , CD11c and CDw 123 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| This cell line expressed CD 4 and CD 38 , but lacked Fc and complement receptors , surface immunoglobulin , CD 19 , HLA DR , and PCA 1 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Flow cytometry showed the T 412 cells to be positive for the T cell markers CD 45 , CD 38 , and CD 4 but negative for all other markers tested . ^^^ The E88 / RF cells are positive for CD 45 and CD 38 but negative for CD 4 and other markers . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Useful methods for characterizing AIDS related non hodgkin ' s lymphomas include immunophenotypic studies using B cell differentiation and activation antigens ( HLA DR , CD 10 , CD 19 , CD 20 , CD 21 , CD 22 , CD 23 , CD 38 ) , evaluation of expression of surface immunoglobulins ( IgS ) , activation and proliferation ( CD 25 , CD 30 , CD 71 , Ki 67 ) , and identification of T cell markers ( CD 1 , CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Several phenotypic markers ( CD 38 , CD 71 , and HLA DR ) that are susceptible to short term effects of ZDV ( but with changes that differ from CD 4 T cell changes ) are surrogate marker candidates for evaluation in anti HIV treatment . . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Surface marker analysis by immunohistochemical technique revealed that neoplastic cells expressed CD 2 , CD 38 , CD 56 and HLA DR but lacked CD 3 , CD 4 and CD 8 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The cell subsets assessed included natural killer cells , B cells , T cells , CD 4 and CD 8 subsets of T cells , and T cell subsets defined by the coexpression of markers that appear ( HLA DR , CD 25 , CD 38 ) or disappear ( CD45RA ) after activation . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Abnormal lymphocytes obtained from a lymph node expressed CD 2 , CD 16 , CD 38 , and CD 56 , but not CD 3 , CD 4 , and CD 8 , so they were natural killer ( NK ) cells . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The remaining fraction of CSF cells mainly consisted of T lymphocytes with a majority of CD 4 positive cells and an increased portion of CD 38 positive cells . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| CD8+ cells that were CD45R+ , 13+ , but CD 38 , were significantly less in HIV+ men with less than 500 CD 4 as compared to HIV homosexual men . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| A majority of the cells from peripheral blood coexpressed the antigens against MAbs CD 2 , CD 3 , CD 4 , CD 5 , Ti ( WT 31 ) , CD 25 , CD 38 , CD 45 , and CD 29 , but did not express the antigens against CD 1 , CD 13 , CD 14 , CD 33 , CD 36 , CD 10 , CD 19 , CD 20 , CD 21 , CD 24 , CD 41 , CD 42 , CD45RA , CD 56 , and CD 57 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The leukemic cells of all these patients coexpressed la ( HLA DR ) , CD 19 , CD 20 , CD 21 , CD 24 , CD 38 , and surface immunoglobulins , whereas a negative reaction with MAbs CD 1 , CD 2 , CD 3 , CD 4 , CD 7 , CD 8 , and Ti ( WT 31 ) , Ti gamma A , delta TCS 1 , and anti TCR gamma / delta was observed . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| These subsets included B , T , CD 4 , and CD 8 cells and subpopulations of CD 4 and CD 8 cells defined by the coexpression of markers that appear ( CD 25 , HLA DR , CD 38 ) or disappear ( Leu 8 , CD45RA ) after activation . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| IL 2 treatment did not induce PBL proliferation , or changes in the expression of CD 25 ( Tac ) , HLA DR , CD 38 , CD 4 , CD 8 , CD 57 , or OKB 7 in the patients ' PBL . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| These cells were largely delta TCS 1 , CD 4 , and CD 8 but expressed activation antigens such as human leukocyte antigen DR and CD 38 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The reason for the restricted responsiveness of CD 4 T cells is presently unclear ; jacalin bound to all blood cells and did not significantly co cap with CD 1 , CD 2 , CD 3 , CD 4 , CD 8 and CD 38 , and jacalin response was neither enhanced nor inhibited by antibodies to these surface antigens . . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| To investigate whether the presence or absence of tissue eosinophilia is related to the immunophenotype of the T cells , we studied 43 cases of HD ( 28 nodular sclerosing , ten mixed cellularity , and five unclassifiable ) for the relative numbers of lymphocytes positive for CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 25 , CD 38 , T 9 , TQ 1 , HLA DR , and beta F 1 , and for the number of eosinophils in tissue sections . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The immunological phenotype of the lymphoma resembled that of immature T cells present in the normal thymus cortex positivity for CD 1 , CD 2 , CD 4 , CD 7 , CD 38 and terminal deoxynucleotidyl transferase ; faint positivity for CD 5 and in the second specimen for CD 3 ; negativity for CD 6 and MHC class 1 antigen . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| CD 4 cells coexpressing CD 38 and HLA DR were significantly increased in HIV+ children ( mean of 2 vs 6 % for < 2 years of age , 3 vs 11 % for 2 3 years , 2 vs 8 % for > or = 4 years ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| CD34bright thymocytes were CD 33 / dull and were negative for CD 38 , CD 2 , and CD 5 as well as for the lineage markers CD 3 , CD 4 , and CD 8 ( T cells ) , CD 19 and CD 20 ( B cells ) , CD 56 ( NK cells ) , glycophorin ( erythrocytes ) , and CD 14 ( monocytes ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| In the absence of gp 120 , CD 4 displayed high association with CD 3 , CD 5 , CD45RC , CD 25 , CD 28 , CD 44 , and CD 53 ; weak association with CD 2 , CD 38 , CD45RB , CD62L , and CD 26 ; and no association with CD45RA , CD45RO , CD11b , CD11a , CD 54 , CD 7 , CD 48 , CD 98 , CD 59 CD55 , HLA class 1 and class 2 molecules . ^^^ Treatment with gp 120 significantly increased CD 4 association with CD 3 , CD45RA , CD45RB , CD 59 , CD 38 , CD 26 and HLA class 1 , and decreased that with CD45RC . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The relative density of lymphocyte CD 3 , CD 4 , CD 5 , CD 8 , CD 20 , CD 23 , CD 28 , CD 38 , CD45RA , CD45RO , CD 57 and HLA DR antigens was measured as antibody binding capacity ( ABC ) in 58 blood donors aged 19 66 years . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Certain correlations characteristic of subpopulation levels of immunocompetent cells identifiable by monoclonal antibody clusters CD 8 , CD 22 , CD 38 and CD 7 ; CD 74 and CD 4 ; CD11b and CD 22 , CD 37 were established . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| In the abnormal lymphocyte cells surface marker test by flow cytometry showed that they expressed CD 2 , CD 3 , CD 4 , CD 29 , CD45RA , and CD 38 , but not CD 8 , CD 16 , and CD 25 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Surface marker analysis using two color immunofluorescence staining characterized blast cells to express CD 34 , CD 38 , CD 117 , and class 2 antigens , coexpressing TdT , CD 4 , CD 7 , CD 13 , CD 19 , and CD 33 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Single , two and three colour flow cytometry was performed using FITC labelled MoAbs directed against the following TCR 5 beta subfamilies : V 2 , V 3 , V5a , V5b , V5c , V 6 , V 8 , V 12 , V13 . 3 , V 17 , V 19 , alone or in combination with PE labelled CD 4 , CD 8 , HLA DR , CD 28 , CD 38 and with Peridinin chlorophyll A protein ( PerCP ) conjugated CD 8 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Markers of immaturity such as CD45RA on CD 4 cells and CD 38 on CD 8 cells declined in both percentages and absolute numbers . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Other markers were occasionally expressed , such as CD 38 , CD45RO , CD 23 , CD 15 , CD 4 , CD 5 , and CD 10 ( expressed on more than 20 % of the hairy cells in 44 % , 25 % , 21 % , 18 % , 12 % , 10 % , and 5 % of evaluated cases , respectively ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| We studied the lymphocyte activation markers CD 25 ( interleukin 2 receptor ) , CD 38 , CDw49b ( VLA 2 ) , CD 71 ( transferrin receptor ) , and HLA DR , as well as the surface antigens CD 3 , CD 4 , CD 7 , and CD 8 by two color flow cytometry in 23 chronic HD patients before and after a single dialysis session ; we also studied 30 normal controls . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The immunophenotype study showed that the leukaemic cells were positive for CD 2 , CD 38 , CD 56 and anti HLA DR monoclonal antibodies and negative for other T cell ( CD 3 , CD 4 , CD 8 ) and B cell markers ( CD 19 , CD 20 and surface immunoglobulins ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| In contrast , other antigens ( CD 7 , CD 3 , CD 4 , CD 8 , CD 38 , CD 9 , CD 10 , CD 24 , CD 19 , CD 20 ) were not consistently altered in drug resistant variants . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The efficacy of this method was evaluated by analyzing leukocytes of 42 healthy donors for the following markers : CD 3 , CD 4 , CD 8 , CD 14 , CD 16 , CD 19 , CD 25 , CD 38 , CD45RO , CD45RA , CD 56 , CD 57 , TCR gamma / delta and HLA DR . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| A series of double labeling experiments revealed that BB 27 mAb identifies new CD 4 and CD 8 cell subsets different from those defined by CD45RA , CD45RO , CD 26 , CD 29 , CD 31 , and CD 38 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| NKL cells express CD 2 , CD 6 , CD11a , CD 26 , CD 27 , CD 29 , CD 38 , CD 43 , CD 58 , CD 81 , CD 94 , CD 95 , class 2 MHC , and the C1 . 7 . 1 antigen , but do not express detectable levels of CD 3 , CD 4 , CD 5 , CD 8 , CD 14 , CD 19 , CD 20 , CD 28 , alpha / beta or gamma / delta T cell receptors on the cell surface . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Using a monoclonal antibody to murine CD 38 , we showed that a population of adult bone marrow cells that expressed the markers Sca 1 and c kit but lacked the lineage markers Mac 1 , GR 1 , B 220 , IgM , CD 3 , CD 4 , CD 8 and CD 5 could be subdivided by the expression of CD 38 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Two types of large complexes containing protein tyrosine kinases were observed : the first one contained CD 3 and the transmembrane proteins CD 2 , CD 4 , CD 5 , CD 6 , CD 7 , CD 8 , CD11a , CD 38 , CD 43 , CD 45 , CD 71 , CD 98 and CD 99 and the other contained mainly the GPI anchored proteins CD 48 , CD 55 , CD 59 and CDw 108 as well as a fraction of CD 4 and CD 8 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Multiparameter FACS analyses of peripheral blood mononuclear cells were performed using antibodies against CD 3 , CD 4 , CD 8 , HLA DR , CD 56 , CD 28 , CD 38 , CD 19 , sIgM , and sIgG . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Quantitative alterations of the functionally distinct subsets of CD 4 and CD 8 T lymphocytes in asymptomatic HIV infection : changes in the expression of CD45RO , CD45RA , CD11b , CD 38 , HLA DR , and CD 25 antigens . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Cells were analyzed from the arterial line before , at 5 , 10 , 15 , 30 , 90 and 240 min with a panel of 33 surface markers including antibodies towards CD 3 , CD 4 , TCR alpha / beta , CD 7 , CD 8 , CD11a c , CD 14 , CD 18 , CD 19 , CD 25 , CD 28 , CD 29 , CD 38 , CD 44 , CD49a e , CD51 / 61 , CD 54 , CD 56 , CD 58 , CD 62 , CD 106 , and HLA class 2 using single fluorescence analysis . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Peripheral blood ( MOAb for immunophenotyping of lymphocytes : CD 14 , CD 45 , CD 3 , CD 19 , CD 4 , CD 8 , CD16 / 56 , HLA DR , CD 38 , CD 25 ) is the material of choice for detection and monitoring of immunodeficiences . ^^^ Extravascular fluids , suspension of single cells and BAL are preferred materials for detection and classification of non Hodgkin lymphomas ( MOAb for immunophenotyping of lymphocytes : CD 14 , CD 45 , CD 3 , CD 19 , CD 4 , CD 8 , CD16 / 56 , HLA DR , CD 38 , CD 25 , CD 23 , CD 5 , CDl1c , CD 30 , light chain immunoglobulins ) . . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Cocapping experiments showed that gp 120 induced CD 4 association with CD 38 , CD 29 , CD49d , and CD11a in peripheral blood CD4+ T cells . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Co capping showed that all four gp120s significantly potentiated CD 4 association with CD 3 , CD45RA , CD45RB , CD 38 , CD 26 , CD 59 and class 1 MHC molecules . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The percentage of cells positive for CD 19 , CD 25 , CD 38 , and CD 71 was significantly lower during convalescence compared with pre IVIG ( medians : CD 19 , 18 % vs 26 % , P = 0 . 0004 ; CD 25 , 6 % vs 9 % for CD 3 ( + ) cells , P = 0 . 0074 ; CD 38 , 78 % vs 89 % for CD 8 ( + ) cells , P = 0 . 0015 ; CD 71 , 1 % vs 6 % for CD 4 ( + ) cells , P = 0 . 0024 ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| These cells express high levels of Sca 1 , H 2K and CD 38 and low levels of Thy 1 . 1 , but do not express CD 34 nor any of the lineage markers including CD 3 , CD 4 , CD 5 , CD 8 NK1 . 1 , 1 A , B 220 , Ig ( MGA ) , CD 40 , kappa , Mac 1 , Gr 1 or Ter 119 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry was performed using monoclonal antibodies ( MAb ) specific for CD 3 , CD 4 , CD 8 , CD 22 , CD 25 , CD 38 , CD 68 , MAb 67 , Ki 67 , interferon gamma ( IFN gamma ) , interleukin ( IL ) 1alpha , IL 1beta , tumour necrosis factor alpha ( TNF alpha ) , E selectin , ICAM 1 and VCAM 1 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| However , CD 4 counts were correlated with CD 38 ABC ( but not RsCD 8 ) in HIV+ patients and with RsCD 8 ( but not CD 38 ABC ) in HIV controls . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Quantitation of CD 38 activation antigen expression on CD8+ T cells in HIV 1 infection using CD 4 expression on CD4+ T lymphocytes as a biological calibrator . ^^^ This value is called the `` RFI multiplier . ' ' To estimate the number of CD 38 antibodies bound per CD8+ T cell ( CD 38 ABC ) on patient samples , we multiply the measured CD 38 RFI value of CD 38 staining using a nominal 1 : 1 conjugate of CD 38 PE by the `` RFI multiplier . ' ' The measurements for CD 4 and CD 38 were stable for 2 years despite the use of different mAb lots and the potential for drift in instrumentation . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| After demonstrating the validity of assay results on cryopreserved cells , we performed a retrospective study using frozen cell samples to determine the predictive value of CD 38 expression in patients with CD 4 counts above 400 cells / microl . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The QuantiBRITE bead method was compared with the CD 4 biological calibration method for quantitation of CD 38 expression on CD8+ T lymphocytes of Multicenter AIDS Cohort Study participants . ^^^ These were the use of repurified ( > 95 % of the monoclonal antibodies [ mAbs ] have 1 phycoerythrin [ PE ] molecule per mAb ) CD 38 PE for both methods and use of repurified CD 4 PE to calculate the relative fluorescence intensity multiplier for the CD 4 biological calibration method . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The vast majority of DPP 4 positive T ALL cases expressed CD 4 , CD 8 , CD 7 , CD 5 , CD 2 along with CD 71 and CD 38 antigens , but the cells were surface membrane CD 3 antigen negative . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Dark blue cells expressing CD 38 , CD 45 , HLA DR , CD 4 , CD11a , CD 29 , CD49d , CD 50 , and CD 54 represented 0 . 30 ( 0 . 21 ) per cent of the mononuclear leucocytes ; most of these cells did not express T , B , NK , myelomonocytic , progenitor cell , proliferation , activation , blood dendritic cell , or follicular dendritic cell markers . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| In PBPC collections , the CD14dimCD16bright monocytes exhibited lower levels of CD11b , CD 15 , CD 33 and CD 38 expression and higher levels of CD 4 , CD11a , CD11c and MHC class 2 , and also revealed a higher percentage of CD4+ cells and a lower percentage of CD15+ cells and CD38+ cells , compared with the CD14+CD16 monocytes . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| An immunophenotypic analysis for CD 3 , CD 4 , CD 8 , CD 19 , CD 33 , CD 34 , and CD 38 antigen expression was performed on apheresis products . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| METHODS : B and T lymphocyte activation was studied by cytometric assessment of the expression of the activation markers CD 38 on B cells and CD 25 and HLA DR on CD 4 ( + ) and CD 8 ( + ) T cell subsets , respectively . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Single CD 34 ( + ) CD 19 ( ) Thy 1 ( + ) ( or CD 38 ( ) ) cells from fresh CB were first induced to proliferate and their progeny separately studied in mouse fetal thymic organotypic cultures ( FTOCs ) and cocultures on murine stromal feeder layers . 10 % of the clones individually analyzed produced CD 19 ( + ) , CD 56 ( + ) , and CD 15 ( + ) cells in stromal cocultures and CD 4 ( + ) CD 8 ( + ) T cells in FTOCs , identifying totipotent progenitor cells . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| METHODS : The proportion of CD 8 T cells that stain for CD 38 and HLA DR , CD 28 and CD 57 was compared with plasma viraemia and CD 4 cell count . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Coincident with these improvements , CD 38 and HLA DR coexpression on both CD 4 and CD 8 T cells decrease , and CD45RA and CD62L coexpression increase . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| This was associated with a very rapid and significant decrease in activation markers [ human leukocyte antigen DR ( HLA DR ) , CD 38 ] on both CD 4 and CD 8 T cell subsets together with a CD8+CD28+ cell increase as early as week 4 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| In patients failing antiretroviral therapy , there was an inverse correlation between the percentage of G 0 G1 cells and expression of the activation antigens CD 38 and HLA DR on CD 4 cells ( r , 0 . 409 ; P = 0 . 016 ) and CD 8 cells ( r , 0 . 363 ; P = 0 . 035 ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Her bone marrow was normocellular with an excess of blasts ( 89 . 1 % , peroxidase stain ( ) , PAS stain ( ) ) that displayed a positive immunophenotype for CD 2 , CD 4 , CD 5 , CD 7 , CD 34 , CD 38 , and CD 71 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry was performed using monoclonal antibodies specific for the following surface markers and cytokines : CD 3 , CD 4 , CD 8 , CD 38 , CD 68 , CD 55 , IL 1beta , IL 6 , and tumor necrosis factor alpha . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Flow cytometry was used to assess RTF expression on activated ( CD 38 ( + ) and HLA DR ( + ) ) CD 4 ( + ) and CD 8 ( + ) T cells . ^^^ HIV ( + ) individuals had higher percentages of RTF ( + ) CD 38 ( + ) ( P < 0 . 0001 ) or RTF ( + ) HLA DR ( + ) ( P = 0 . 0001 ) CD 4 ( + ) T cells than HIV ( ) individuals . ^^^ In HIV ( + ) individuals , increased percentages of CD 4 ( + ) T cells that were RTF ( + ) , RTF ( + ) CD 38 ( + ) , and RTF ( + ) HLA DR ( + ) correlated inversely with the absolute number and percentage of CD 4 ( + ) T cells and correlated positively with plasma beta ( 2 ) microglobulin concentrations . ^^^ In HIV ( + ) individuals , increased percentages of CD 8 ( + ) T cells that were RTF ( + ) HLA DR ( + ) correlated inversely with the percentage of CD 4 ( + ) T cells , and high percentages of CD 8 ( + ) T cells that were RTF ( + ) CD 38 ( + ) correlated positively with plasma beta ( 2 ) microglobulin levels . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| ST sections were analysed by immunohistochemistry using monoclonal antibodies against CD 3 , CD 4 , CD 8 , CD 22 ( B cells ) , CD 38 ( plasma cells ) , CD 68 ( macrophages ) and CD 55 ( fibroblast like synoviocytes ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate ( by three and four color flow cytometry ) that this depletion is specific to a definable subset of CD 4 ( + ) T cells , namely , those having both a highly and / or acutely activated ( CD 69 ( + ) CD 38 ( + ) HLA DR ( + ) ) and memory ( CD45RA ( ) Leu 8 ( ) ) phenotype . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| CD 38 displays lateral association with the HIV 1 receptor CD 4 . ^^^ This correlation was at first suggested by results obtained in a panel of human CD 4 ( + ) T cell lines expressing different CD 38 levels ( MT 4 , MT 2 , C 8166 , CEMx 174 , Supt 1 , and H 9 ) and then demonstrated using CD 38 transfectants of MT 4 cells ( the line with the lowest CD 38 expression ) . ^^^ F1 T cells produced four lines expressing human CD 4 and / or CD 38 . ^^^ Ability of CD 4 ( + ) CD 38 ( + ) cells to bind HIV 1 or purified recombinant gp 120 was significantly lower than that of CD 4 ( + ) CD 38 ( ) cells . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Expression of CD 3 , CD 4 , CD 8 , CD 25 , CD 38 , CD 56 , CD 71 , CD 122 , and HLA DR antigens , serum level of the soluble IL 2R alpha , and NK activity against K 562 cell line were evaluated in 11 patients representative for both types of immunotherapy . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The percentage of CD 4 and CD 8 lymphocytes did not vary during the STI period ; however , the level of expression of T cell activation antigen CD 38 on CD 8 T cells increased significantly in response to viral rebound . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| However , small decreases in HLA DR ( + ) CD 38 ( + ) lymphocytes and of CD45RA ( + ) CD62L ( + ) were observed within both the CD 4 ( + ) and CD 8 ( + ) subsets . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| However , for all sample processing methods above , the CD 4 biologic calibrator and QuantiBRITE bead methods gave significantly different estimates of CD 38 intensity . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| METHODS : Multidimensional flow cytometric analysis was performed on the lymphoid cells extracted from 27 thymic epithelial neoplasms ( 14 encapsulated thymomas , ten invasive thymomas , and three thymic carcinomas ) by using anti CD 3 , CD 4 , CD 8 , CD 10 , CD 20 , CD 38 , CD45RA , and CD45RO monoclonal antibodies . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Triple therapy was significantly more effective in reducing plasma HIV RNA to undetectable levels , in returning CD 4 : CD 8 ratio to nearly normal levels , in reducing activated cells ( CD 38 ) and in increasing naive ( CD45RA+CD45RO ) and memory ( CD45RA CD45RO+ ) CD 4 cells . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Peripheral blood lymphocytes were highly pleomorphic and presented CD 2 , CD 4 , CD 25 , CD 38 membrane surface antigens . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| In contrast , development of CD 34 ( + ) CD 38 ( ) cells into CD 4 ( + ) CD 14 ( + ) DC 1 precursors and mature DC 1 was not affected by ectopic Id 2 or Id 3 expression . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Compared with healthy controls , CD 4 and CD 8 T cells from patients with HIV and / or PTB expressed more activation markers ( HLA DR , CD 38 ) ; their CD 8 T cells expressed more CD 95 ( pre apoptosis ) and less CD 28 ( co stimulatory receptor ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Here we explored a scoring system for HIV disease markers that combines measures of immunodeficiency ( CD 4 cell count ) , plasma viral burden , and immune activation ( CD 38 expression on CD 8 T cells ) DESIGN : Observational data from 252 HIV infected individuals from the Multicenter AIDS Cohort Study ( MACS ) was used for model development . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| We show that in vivo thymic DC express E cadherin , CLA , CD 4 , CD 38 , CD 40 , CD 44 , and granulocyte macrophage colony stimulating factor R ( GM CSF R ; CD 116 ) but no CD1a . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The plasma levels of sTNFR 2 , sCD 27 , b ( 2 ) m , IL 12 , and IgG were inversely correlated with numbers of CD 4 ( + ) T cells , the proportion of nave ( CD45RA ( + ) CD 27 ( + ) ) CD 8 ( + ) T cells , and the proportion of CD 8 ( + ) T cells expressing CD 28 ( CD 8 ( + ) CD 28 ( + ) ) were positively correlated with the proportions of activated ( HLA DR ( + ) CD 38 ( + ) ) CD 4 ( + ) T cells , as well as activated ( HLA DR ( + ) CD 38 ( + ) ) CD 8 ( + ) T cells . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Differential susceptibility of resting CD 4 ( + ) T lymphocytes to a T tropic and a macrophage ( M ) tropic human immunodeficiency virus type 1 is associated with their surface expression of CD 38 molecules . ^^^ Flow cytometric analysis permitted us to detect CD 38 , a surface marker of early differentiation , as well as activation of T cells , on about half of healthy donor derived CD 4 ( + ) T cells . ^^^ In this study , we focused on the susceptibility of CD 38 ( + ) and CD 38 ( ) subsets of CD 4 ( + ) T cells to HIV 1 infection with different coreceptor tropisms . ^^^ About 20 % of peripheral blood mononuclear cell derived resting CD 4 ( + ) T cells were recovered into the CD 38 ( + ) subset fraction by panning with a monoclonal antibody to CD 38 . ^^^ CCR 5 ( + ) T cells predominated in the CD 38 ( ) subset , although cell surface expression of CD 4 and CXCR 4 was almost similar between both subsets . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| There was near unanimity that additional markers ( selected from CD 22 , FMC 7 , CD11c , CD 103 , CD 38 , CD 25 , CD79b and heavy chains for B cell disorders , and CD 4 , CD 7 , CD 8 , CD 2 , CD 56 , CD 16 , TCRa / b , and TCRg / d for T cell disorders ) would be needed to fully characterize CLD , although not every marker would be useful in all cases . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| There were no differences in trends between groups in CMV DNA , CD 4 cell counts , activated ( CD 38 % or human leukocyte antigen DR ) CD 8 cell counts , or plasma cytokine levels . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Isolated peripheral blood lymphocytes were stained for the lymphocyte subset markers CD 4 , CD 8 , CD 19 , their respective activation markers CD 25 , HLA DR , CD 38 , and the costimulatory molecules CD40L , CD 28 , CD 40 , CD 80 , and CD 86 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| We also examined the association of CD 4 , CD 38 , and antiretroviral therapy ( ART ) use with these outcomes in the subset of HIV infected adolescents . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| METHODS : Four color cytofluorometry with appropriate conjugated monoclonal antibodies ( mAbs ) was performed to define CD45RA and CD45RO subsets of CD 4 and CD 8 T cells and measure their expression of CCR 5 , CXCR 4 , and CD 38 . ^^^ CCR 5 expression but not CXCR 4 expression correlated with other measures of immunodeficiency ( CD 4 T cell levels ) , active infection ( viral load ) , and cellular activation ( CD 38 ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Flow cytometric analysis of adult stem cell populations revealed positive staining for CD 34 and CD 90 and negative staining for CD 3 , CD 4 , CD 8 , CD11c , CD 33 , CD 36 , CD 38 , CD 45 , CD 117 , Glycophorin A , and HLA DR II . . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Expression of HLA DR , CD 38 and CD 95 increased on both CD 4 and CD 8 T lymphocytes whereas CD 25 induction was observed exclusively on CD 4 T cells . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Baseline liver enzymes , serum CD 38 , CD 4 , and HIV viral load data were collected . ^^^ Patients with low CD 4 counts , high initial viral load , or high CD 38 expression still experienced a significant change in viral load . . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| MAb to antigens CD 25 , CD 8 , CDw 50 , CD 5 , CD 4 , CD 7 , CD 3 , CD 71 , CD 34 , CD 45 , CD 38 , CD11b , CD 16 , and CD 95 have gained worldwide recognition at International HDLA Workshop Conferences . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| For this purpose , various differentiation and activation marker ( CD45RA , CD 27 , HLA DR , and CD 38 ) expressions on CD 4 ( + ) and CD 8 ( + ) T cells were studied in 60 male , human immunodeficiency virus negative subjects ( 30 from each site ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Lymphocyte subset markers ( CD 4 , CD 8 , CD45RA , CD62L , CD 16 , CD 19 ) , activation markers ( HLA DR , CD 38 , CD 25 ) were performed by cytometry analysis . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The studied antigens were the following : CD 3 , CD 4 , CD 8 , CD 14 , CD 19 , CD 25 , CD 38 , CD 45 , CD45RO , CD 54 , CD 56 , CD62L , CD 71 and HLA DR . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Resting CD 4 ( + ) T cells with CD 38 ( + ) CD62L ( + ) produce interleukin 4 which contributes to enhanced replication of T tropic human immunodeficiency virus type 1 . ^^^ We previously reported a higher replication rate of T tropic HIV 1 in the CD 4 ( + ) CD 38 ( + ) CD62L ( + ) than CD 38 ( ) subset under conditions of mitogen stimulation after infection . ^^^ Thus , the CD 4 ( + ) CD 38 ( + ) CD62L ( + ) subset comprises a specific cell population secreting endogenous Th 2 cytokine that contributes to the efficient production of T tropic HIV 1 through upregulation at a certain stage of the viral life cycle , probably after the adsorption step . . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Overall , we found that HIV RNA and CD 38 levels were similarly predictive of AIDS early on compared with a relatively weaker CD 4 cell count signal . ^^^ Later in the course of infection , CD 38 level remained the strongest predictive marker and CD 4 cell count registered a marked increase in prognostic power . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| By flow cytometry , the number of lymphocytes , granulocytes , epithelial cells and red blood cells was analysed as well as the expression on lymphocyte subsets of the following antigens : CD 3 , CD 4 , CD 8 , CD 19 , CD 25 , CD 38 , CD45RO , CD45RA , HLA DR , TcRgd , CD 161 and l selectin . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| We report the finding that in HIV 2 and HIV 1 patients with a comparable degree of CD 4 depletion the imbalance in the relative sizes of the naive and memory T cell populations and the up regulation of CD 4 and CD 8 cell activation markers ( HLA DR , CD 38 , CD 69 , Fas molecules ) are similar , even though the viral load in the plasma of HIV 2 infected patients is two orders of magnitude lower than in HIV 1 patients and HIV 2 patients are known to have slower rates of CD 4 T cell decline and a better clinical prognosis . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| In addition , the percentages of CD 38 positive B cells , activated T cells ( CD 4 ( + ) / CD25 ( + ) , CD 8 ( + ) / CD38 ( + ) ) and HLA DR expressing NK cells were reduced during therapy with MMF . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| CD 4 percent correlated inversely with Ki 67 expression in CD 4 memory , CD 8 naive , and CD 8 memory cells , while Ki 67 expression in CD 4 and CD 8 memory cells correlated directly with average CD 38 molecules / CD8 cell and absolute number of CD8 / CD38 / HLA DR cells , consistent with T cell activation . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Flow cytometry was used to detect the count of CD 4 ( + ) T lymphocytes , CD 8 ( + ) T lymphocytes , and its different subsets including the naive cell subset ( CD 4 ( + ) CD45RA ( + ) CD62L ( + ) ) , activated cell subsets ( CD 4 ( + ) HLA DR ( + ) , CD 8 ( + ) HLA DR ( + ) , CD 8 ( + ) CD 38 ( + ) ) , functional cell subsets ( CD 4 ( + ) CD 28 ( + ) ) , and apoptotic cell subsets ( CD 4 ( + ) CD 95 ( + ) , CD 8 ( + ) CD 95 ( + ) ) . ^^^ The percentages of CD 4 ( + ) HLA DR ( + ) , CD 8 ( + ) HLA DR ( + ) , and CD 8 ( + ) CD 38 ( + ) in the AIDS patient group were higher than those in the HIV infected person group and control group with significant difference between any two groups ( all P < 0 . 01 ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Phenotypic characterization of these Valpha24+ Vbeta11+ clones indicated that they were predominately positive for CD 4 , CD 161 , HLA DR , CD 38 , CD45RO , and CD 95 expression . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| CD 38 is a progression marker in HIV 1 infection , it displays lateral association with CD 4 , and down modulates gp120 / CD4 binding . ^^^ The aim of this study was to elucidate the mechanism behind the interplay between CD 4 , CD 38 , and HIV 1 . ^^^ We used mouse cell transfectants expressing human CD 4 and either CD 38 or other CD 4 associated molecules to show that CD 38 specifically inhibits gp120 / CD4 binding . ^^^ Conversely , a deletion in the V 3 like region abrogated the anti HIV 1 activity of CD 38 and its lateral association with CD 4 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Coculture of LCL with EBV specific CD 4 ( + ) T cells resulted in an altered phenotype , characterized by elevated CD 38 expression and decreased proliferation rate . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| METHODS : Flow cytometry ( FCM ) was used to detect the concentration of lymphocyte subsets , such as CD 3 , CD 4 , CD 8 , NK and CD 19 , as well as CD 34 ( + ) cell subsets , such as CD 34 ( + ) CD 38 ( ) , CD 34 ( + ) Thy 1 ( + ) and AC 133 ( + ) in PB or PBPC during autologous peripheral blood stem cell transplantation ( APBSCT ) during high dose chemoradiotherapy ( HDC ) with recombinant human granulocyte colony stimulating factor ( rhG CSF ) in 47 consecutive patients with malignant solid tumor . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Apoptosis was assessed via CD 95 , Apo2 . 7 expression and annexin 5 binding in peripheral CD 4 , CD 8 , B and NK cells , and compared to changes in activation markers ( HLA DR , CD 38 ) and viral loads . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| In AIDS KS , CD 3 , CD 4 , CD 8 , NK and HLA DR ( + ) CD 8 were lower than those in HIV NKS whereas CD 19 and CD 38 ( + ) CD 8 were higher than those in HIV NKS . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Nonresponders had higher CD 4 ( + ) T cell proliferation ( as assessed by Ki 67 expression ) and immune activation ( as assessed by CD 38 and human leukocyte antigen DR expression ) , together with a reduction in T cell receptor excision circles , compared with discordant immunological responders and complete responders , which suggests that there is enhanced viral pathogenicity in both peripheral T cells and the thymus . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Maturation of adult peripheral blood CD 38 ( + ) CD 4 ( + ) T cells demonstrated by cytokine production in response to a superantigen , TSST 1 . ^^^ We compared the function of APB CD 38 ( + ) CD 4 ( + ) and CD 38 ( / low ) CD 4 ( + ) T cells to that of cord blood ( CB ) CD 4 ( + ) T cells . ^^^ APB CD 38 ( + ) CD 4 ( + ) T cells produce low levels of IL 4 and IFN gamma in response to TSST 1 , even after activation , while APB CD 38 ( / low ) CD 4 ( + ) T cells retain their ability to produce high levels of these cytokines despite high CD 38 expression . ^^^ These results suggest that the developmental stage of APB CD 38 ( + ) CD 4 ( + ) T cells lies between that of CB CD 4 ( + ) T cells and APB CD 38 ( / low ) CD 4 ( + ) T cells and that APB CD 38 ( + ) CD45RO ( ) CD 4 ( + ) T cells gradually cease to express CD 38 as they acquire full function . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Although there were no differences in CD 4 ( + ) or CD 8 ( + ) T cell counts or the percentage of cells that were CD 4 ( + ) CD 25 ( + ) , CD 8 ( + ) CD 25 ( + ) , or CD 4 ( + ) DR ( + ) , patients who received SIT had a significantly higher percentage of CD 8 ( + ) CD 38 ( + ) and CD 8 ( + ) DR ( + ) cells . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| These cells were also positive for epithelial membrane antigen , CD 4 , CD 19 , CD 38 , CD 138 , cytoplasmic IgG , and lambda chain , but negative for CD 30 ( Ber H 2 ) , CD 56 , CD 57 , and other T and B cell markers . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Distribution of naive and memory / effector CD 4 + T lymphocytes and expression of CD 38 on CD 8 + T lymphocytes in AIDS patients with tuberculosis . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Children with full ( < 40 copies / mL ) or partial ( < 50 , 000 copies / mL ) virus suppression and with a history of stable CD 4 ( + ) T cell counts had significantly increased levels of anti HIV CD 4 ( + ) T cell lymphoproliferative responses , lower levels of CD 38 ( + ) , and higher CD 8 ( + ) / CD28 ( + ) T cell percentage , compared with those in treated children with a lack of virus suppression ( > 50 , 000 copies / mL ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The immunoprofile of the cells was positive for CD 45 , HLA DR , CD 30 and negative for EMA , CD 34 , CD 38 , CD 2 , CD 3 , CD 4 , CD 7 , CD 8 , CD 10 , CD 15 , CD 19 and CD 20 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Changes in total and memory CD 4 and CD 8 cells were similar in the groups , as were decreases in immune activation ( e . g . , CD 38 and HLA DR ) and increases in CD 28 expression . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Activated ( HLA DR CD 38 ) CD 4 and CD 8 T cells were elevated at baseline ( 24 and 62 % , respectively ) and declined by week 48 ( 17 and 36 % , respectively ) but did not reach normal levels . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The phenotype of IL 17 and IFN gamma producing cells was evaluated by immunohistochemistry using the CD 3 and CD 4 T cell markers , the CD 20 , CD 38 , kappa and lambda light chain B cell lineage markers . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The percentage of CD 4 ( + ) and CD 8 ( + ) T cell subsets expressing CD 38 and HLA DR activation markers was positively correlated with plasma viral load and tended to normalize . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The immunophenotype of peripheral blood mononuclear cells ( CD 4 , CD 38 , CD 8 , CD 23 , CD 25 , CD 57 , CD 30 , HLA DR ) was analyzed by flow cytometry . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| MAIDS infected mice also have CD 4 ( + ) T cells with significantly higher expression levels of CD 38 and particularly CD 69 , which have been demonstrated to be regulator T cell markers in the Friend retroviral model . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| RESULTS : HR 8348 cell line did not express CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , TCR , CD 10 , CD11b , CD 14 , CD 16 , CD 19 , CD 22 , CD 25 , CD 28 , SmIg , CD 33 , CD 35 , CD 36 , CD41a , CD 45 , CD45RA , CD45RO , CD 56 , CD 61 , CD 64 , CD66b , CD 69 , CD 71 , CD 117 , CD 122 and P glycoprotein but expressed CD 13 , CD 15 , CD 20 , CD 38 , CD 95 and HLA DR . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| METHODS : Paraffin embedded tissue samples from 23 affected submandibular glands were immunostained for T cells ( CD 3 , CD 4 , CD 8 ) , cytotoxic T cells ( granzyme B ) , B cells ( CD 20 ) , plasma cells ( CD 38 ) and macrophages ( Ki M1P ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| In this report we evaluated CD 4 ( + ) T , CD 8 ( + ) T and natural killer ( NK ) cell counts , the levels of naive / memory subsets within the CD 4 ( + ) T lymphocyte population , expression of CD 38 on T lymphocytes , and CD 4 ( + ) and CD 8 ( + ) T cell cytokine production in two girls with hyper IgM ( HIM ) syndrome . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The T cell markers were characterized using a monoclonal antibody panel including CD 3 , CD 4 , CD 8 , CD 25 , CD 29 , CD 38 , CD45RA , CD45RO , CD 54 and HLA DR . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Higher absolute CD 8 ( + ) CD 38 ( + ) T cell counts at the start of the assessment period were associated with a greater rate of loss of CD 4 ( + ) T cells . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The measurements of CD 4 ( + ) and CD 8 ( + ) T lymphocyte subsets ( CD45RA , CD45RACD62L , CD45RO , CD 28 , CD 38 ) were carried out by flow cytometry . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Mathematical modeling supports the hypothesis that the differentiation blockade is one major reason for the depletion of CD 4 cells and the proliferation of CD 38 cells in HIV 1 infection . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| CD 4 ( + ) CD45RA ( hi+ ) CD62L ( + ) , CD 4 ( + ) CD45RA ( + ) and CD 4 ( + ) CD 38 ( + ) percentages , and the CD 8 ( + ) CD45RA ( hi+ ) CD62L ( + ) counts reached similar values to the control group . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| We describe here that primary human adenotonsillar memory phenotype CD45R0 ( + ) CD 4 ( + ) T cells , but not adenotonsillar naive phenotype CD45RA ( + ) CD 4 ( + ) T cells , or peripheral blood naive or memory CD 4 ( + ) T cells , express high levels of activation associated antigens CD 38 , CD 69 , CD 71 , and HLA DR . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Indirect immunofluorescence was used to determine the count of CD 3 , CD 4 , CD 80 , CD 38 , CD 25 , CD 71 , and CD 95 lymphocytes . ^^^ Unlike cancer diseases , pulmonary tuberculosis was characterized by the combination of a significantly inverse correlation between the relative count of CD 3 , CD 4 , CD 8 lymphocytes the levels of thymogen antibodies with a significantly direct correlation between the absolute count of CD 25 and CD 38 lymphocytes . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| A higher HIV RNA level also was associated with increases in activated CD 8 ( + ) CD 38 ( + ) and CD 8 ( + ) HLA DR ( + ) cells ( P < . 05 ) , and a higher level of activated CD 8 ( + ) CD 38 ( + ) cells was independently associated with reduced CD 4 gain ( P < . 05 ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The proportion of CD 3 ( + ) CD 4 ( + ) , CD 3 ( + ) CD45RO ( + ) and CD 3 ( + ) CD 38 ( + ) cells was significantly higher , but proportion of CD 3 ( + ) CD45RA ( + ) and CD 3 ( + ) CD 8 ( + ) cells was significantly lower in FBS compared with HCBP supplemented medium ( p < 0 . 05 ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Coexpression of CD 38 and HLA DR on both CD 4 ( + ) and CD 8 ( + ) T cell subsets was directly correlated with viral load and inversely correlated with CD 4 ( + ) T cell counts . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| We previously reported that primary culture of resting CD 4 ( + ) CD 38 ( + ) T lymphocyte subset had higher production rate of CXCR 4 using ( X 4 ) HIV 1 than CD 4 ( + ) CD 38 ( ) subset . ^^^ Thus , IL 4 dependent X 4 HIV 1 transcription occurs efficiently in the CD 38 ( + ) but not CD 38 ( ) subset of CD 4 ( + ) population and AP 1 could play a significant role on viral transcription , leading to the up regulated X 4 virus production in the CD 38 ( + ) subset . . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The HLA DR , CD 38 and CCR 5 expression on CD 4 , CD8+ T cells in AIDS patients was higher than in asymptomatic HIV 1 infected patients and normal controls ( p < 0 . 05 ) ; The activation and CCR 5 expression on T lymphocytes significantly correlated with CD4+ T lymphocyte number and viral load . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| CD 38 ( + ) CD 8 ( + ) T cell percentages may , rather , provide a sensitive estimate of the overall immune recovery , and be a useful extra laboratory parameter to CD 4 counts that would contribute to improve the clinical management of HIV infected people when VL testing facilities are lacking . . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The immunophenotype was examined for the maturation dependent myeloid antigens CD 13 , CD 33 , CD11b , CD 14 , CD 15 , CD 65 , CD 36 , cytoplasmic MPO , non lineage associated CD 34 and HLA DR antigens , lymphoid associated antigens CD 7 , CD 4 , CD 38 as well as natural killer cell associated marker CD 56 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Also , we performed immunohistochemical assessments of CD 3 , CD 4 , CD 8 , CD 20 , CD 38 , CD 138 , CD 68 , CD 163 , CD 83 , CD1a , CD 146 , alphaVbeta 3 , E selectin , intercellular adhesion molecule 1 , vascular cell adhesion molecule 1 , S100A12 , intracellular citrullinated proteins and major histocompatibility complex ( MHC ) human cartilage ( HC ) gp 39 peptide complexes . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Early proliferation of CCR 5 ( + ) CD 38 ( +++ ) antigen specific CD 4 ( + ) Th 1 effector cells during primary HIV 1 infection . ^^^ In the peripheral blood of subjects with very early PHI ( < 22 days after onset of symptoms ) , there was a 10 to 20 fold increase in the proportion of highly activated ( CD 38 ( +++ ) ) and proliferating ( Ki 67 ( + ) ) CD 4 ( + ) T cells that expressed CCR 5 ( + ) , and were mostly T cell intracellular antigen 1 ( TIA 1 ) ( + ) perforin ( + ) granzyme B ( + ) . ^^^ Inthe same patient samples , CD 4 ( + ) T cells producing interferon ( IFN ) gamma in response to HIV group specific antigen ( Gag ) peptides were readily detected ( median , 0 . 58 % ) by intracellular cytokine assay these cells were again predominantly CD 38 ( +++ ) , Ki 67 ( + ) , and TIA ( ++ ) , as well as Bcl 2 ( low ) . ^^^ However , in PHI subjects with later presentation , antigen specific CD 4 ( + ) T cells could not be readily detected ( median , 0 . 08 % ) , coinciding with a 5 fold lower level of the CCR 5 ( + ) CD 38 ( +++ ) CD 4 ( + ) T cells . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| These data are consistent with the increased CD 38 expression and lipid raft formation , and the significant reduction in the CD 4 : CD 8 ratio observed in mitogen stimulated normal T cells as compared with that in ex vivo untouched normal T cells . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The most significant changes during the 48 week study period were seen for CD 8 ( + ) , CD 8 ( + ) CD62L ( + ) CD45RA ( + ) , CD 8 ( + ) CD 38 ( + ) HLA DR ( + ) , and CD 4 ( + ) T cell percentages ( P < . 0001 for all parameters ) . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| TPA induced the following antigens in decreasing order of the change : CD11c , CD 9 , CD11b , CD 54 , CD 38 , CD45RO and CD66c , with repression of CD 4 , CD 117 , CD 95 , CD 71 and CD 64 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| HRSN had higher naive ( CD45RO CD 27 ) CD 4 and CD 8 T cell numbers and lower percentages of activated ( HLADR CD 38 , CD 70 ) CD 4 and proliferating ( Ki 67 ) CD 4 and CD 8 T cells , irrespective of previous episodes of sexually transmittable infections . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Overall , CD 4 ( + ) T cell counts increased during follow up , whereas CD 38 expression remained stable . ^^^ No association could be found between long term gains in CD 4 ( + ) T cells and evolution of CD 38 expression . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| The blast cells expressed CD 4 , CD 19 , CD 22 , CD 33 , CD 38 , CD79a , and HLA DR and showed rearrangement of the immunoglobulin heavy chain and TCR 3 genes . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Increased CD 4 ( + ) T cell activation , as indicated by co expression of HLA DR and CD 38 , was an independent risk factor for treatment failure ( hazard ratio = 2 . 45 , 95 % confidence interval = 1 . 02 5 . 89 , P = 0 . 05 ) in multivariate analysis controlling for age , baseline temperature , and pre treatment parasite density . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Accordingly , there was no decrease of the cellular infiltration with T lymphocytes ( CD 3 , CD 4 , CD 8 ) , B lymphocytes ( CD 20 ) , plasma cells ( CD 38 ) , dendritic cells ( CD1a , CD 83 ) , and even an increase of CD163+ sublining macrophages , with a similar trend for CD68+ sublining macrophages . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Subclasses of T , B and NK lymphocytes were tested for in the blood samples : CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD11B , CD 16 , CD 20 , CD 25 , CD 38 , CD45RA , CD 50 , CD 71 and CD 95 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Lymphocyte subpopulations were studied by flow cytometry , including the markers : CD 3 , CD 4 , CD 7 , CD 8 , CD45RO , CD 38 , HLA DR and CD 25 . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| We assessed proliferation ( Ki 67 ) , activation ( HLA DR , CD 38 ) and replicative senescence ( CD 57 ) by flow cytometry and CD 4 ( + ) T cell responses to CMV by IFN gamma ELISpot . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| DESIGN : The effects of IFN alpha on spontaneous apoptosis and CD 38 expression among T cell subsets were determined in vitro and studied in relation to CD 4 cell counts , plasma HIV RNA levels and the age of the subjects . ^^^ The reduced protection of IFN alpha among CD 4 cells from HIV infected persons was not related to the percentages of activated ( CD 38 or CD45RO+CD38+ ) cells . ^^^ Surprisingly , IFN alpha induced CD 38 expression among CD 8 T cells from HIV infected persons , and the magnitude of this effect was directly related to circulating CD 4 T cell count . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Furthermore , children with low percentage of CD 4 ( + ) showed significant upregulation of HLA DR ( + ) CD 38 ( + ) and HLA DR ( + ) in both CD 4 ( + ) and CD 8 ( + ) T cells independent of VL levels . ^^^ |
|
| Interacting proteins: P28907 and P01730 |
Pubmed |
SVM Score :0.0 |
| Before injection , GFP positive bone marrow cells were fractionated in a 63 % Percoll solution and then were exhausted from differentiated cells by magnetic manner using CD 4 , CD 8 , CD 38 , CD45R , CD 119 , Ly 6G , and F4 / 80 antibodies . ^^^ |
|