Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
To investigate the role of dipeptidylpeptidase 4 on CD 4 positive cells in wound healing we used Lys [ Z ( NO 2 ) ] Pro , a chemically modified dipeptide which may result by degradation of polypeptides by this peptidase . ^^^ Our results suggest that : ( 1 ) the CD 4 positive T helper subset regulates wound healing , and ( 2 ) products of degradation by dipeptidylpeptidase 4 may bypass T helper cell function . . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Using these hybrids it is demonstrated that expression of CD 4 and CD 26 , the T cell activation antigen dipeptidyl peptidase 4 recently proposed as a CD 4 cofactor necessary for HIV 1 infection , are not sufficient for HIV 1 entry . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Plasma levels of cytomegalovirus ( CMV ) specific immunoglobulin G ( IgG ) , soluble ( s ) CD 30 , sCD 26 ( dipeptidyl peptidase 4 [ DPP 4 ] ) enzyme activity , and tumor necrosis factor receptor 1 ( TNFR 1 ) were assessed in human immunodeficiency virus ( HIV ) infected patients who experienced CMV retinitis ( CMVR ) as an immune restoration disease ( IRD ) during their first 6 months of highly active antiretroviral therapy ( HAART ) and in CMV seropositive , HIV infected patients with similar baseline CD 4 ( + ) T cell counts who had uneventful immune reconstitution . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Hydrocortisone ( HC ) treatment in vivo resulted in ( 1 ) reduction of the relative thymus weight and absolute thymocyte counts ; ( 2 ) relative decrease of the CD 4 ( + ) CD 8 ( + ) thymocyte proportion accompanied by an increase of single positive and double negative thymocyte populations , the latter of which contained large CD 3 negative cells expressing a high level of CD 26 on their surface ; ( 3 ) increase of specific dipeptidyl peptidase 4 ( DPP 4 ) activity in thymocyte homogenates . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
The role of the T cell activation antigen CD 26 was evaluated in viral entry and infection of CD 4 ( + ) / CXCR4 ( + ) cells by the lymphotropic HIV 1 Lai isolate . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
No differences in expression of the CD 2 , CD 3 , CD 4 , Tp 103 , and CD 28 Ag between these cells and the parental cells could be demonstrated , with the exception of the expression of IL R p 55 and HLA DR Ag , which were constitutively expressed on the phase 1 cells . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Anti CD 4 and CD 8 antibodies inhibit alternative , nonreceptor pathways of T cell triggering via Tp 103 and Tp 44 in the absence of class 2 positive accessory or target cells . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
The T cell line expressed CD 2 , CD 3 , CD 4 , CD45RA , CD 29 , HLA DR , CD 25 , and CD 26 antigens , but not CD 8 and CD 20 antigens . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
In the present report , we demonstrated that modulation of CD 26 from T cell surface induced by antiCD 26 ( 1F7 ) led to enhanced phosphorylation of CD 3 zeta tyrosine residues and increased CD 4 associated p56lck tyrosine kinase activity . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Three years following the accident , exposed subjects were compared to residents of a nearby unexposed community for the following immunological parameters : white blood cell count , total lymphocyte count , percent and total lymphocyte subsets ( CD 5 , CD 4 , CD 8 , CD 19 , CD 25 , and CD 26 cells ) , prevalence of autoantibodies , and antibodies to HCHO human serum albumin ( HCHO HSA ) conjugate . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Significantly , we demonstrated that both the 1F7 ( CD 26 ) structure and the VLA integrin family , particularly the VLA 3 complex , contribute to the functional interaction between collagen and CD 4 cells since anti 1F7 and anti VLA 3 specifically inhibited this collagen induced CD 4 cell activation . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
On PTCs , the antigenic density was high for CD 4 and CD 26 antigens and low for CD 2 ; they furthermore reacted with the mAb OKM 5 recognizing an undefined antigen associated with the myelomonocytic lineage and expressed the monocyte associated antigen CD 68 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
In the absence of gp 120 , CD 4 displayed high association with CD 3 , CD 5 , CD45RC , CD 25 , CD 28 , CD 44 , and CD 53 ; weak association with CD 2 , CD 38 , CD45RB , CD62L , and CD 26 ; and no association with CD45RA , CD45RO , CD11b , CD11a , CD 54 , CD 7 , CD 48 , CD 98 , CD 59 CD55 , HLA class 1 and class 2 molecules . ^^^ Treatment with gp 120 significantly increased CD 4 association with CD 3 , CD45RA , CD45RB , CD 59 , CD 38 , CD 26 and HLA class 1 , and decreased that with CD45RC . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
MEC cultures expressed low levels of surface CD 4 , galactosylceramide and CD 26 , but essentially no human leukocyte antigen ( HLA ) DR . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Alterations in the expression of cell surface receptors have been reported in HIV infected cells for CD 4 , CD 25 ( IL 2 receptor ) , CD 2 , CD 3 and CD 8 and CD 26 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
CD 26 to be or not to be a cofactor for CD 4 receptor of human immunodeficiency viruses . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
The study of peripheral blood purified T cells was carried out using single colour immunofluorescence and flow cytometry analysis ( Ortho Diagnostic System ) with monoclonal antibodies such as OKT 4 ( CD 4 , helper / inducer ) , OKT 8 ( CD 8 , cytotoxic / suppressor ) , OKDR and MLR 4 ( activated T cells ) , and Tec 5 / 9 ( CD 26 , activated T cells with specific helper function for B cell differentiation ) . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
The binding was inhibited either by soluble CD 4 or by CD 4 monoclonal antibody ( mAb ) MT 151 , which recognizes the CDR 3 region of the D 1 domain of CD 4 , but not by other CD 4 mAbs Leu3a , OKT4A , Q 4021 , 13B8 2 , 5A8 , RFT 4 , nor by the CD 26 mAb BA 5 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
We conclude that PMA inhibits the CD 4 gp120 gp 41 mediated fusion by modulating an accessory component ( s ) , different from CD 26 , in the target CD 4 expressing cells . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Coexpression of human CD 4 and CD 26 in murine NIH 3T3 cells rendered them permissive to infection by HIV 1 and HIV 2 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
It has been proposed recently that the cell surface peptidase CD 26 acts in concert with CD 4 , the human immunodeficiency virus ( HIV ) primary receptor molecule , to mediate HIV entry into permissive cells . ^^^ NIH 3T3 cells stably transfected with the cDNAs for human CD 4 and CD 26 expressed these molecules at the cell surface and had CD 26 enzymatic activity . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Targeting of an activated T cell subset using a bispecific antibody toxin conjugate directed against CD 4 and CD 26 . ^^^ We have developed a bispecific antibody that recognizes the CD 4 and CD 26 antigens simultaneously and that was examined for its ability to target CD4+CD26+T cells . ^^^ The purified bispecific antibody exhibited an estimated dissociation constant ( kd ) of 2 . 4 10 10 ( 9 ) mol / L , on comparison with 1 . 1 10 10 ( 9 ) mol / L for anti CD 26 , and 1 . 6 10 10 ( 10 ) mol / L for anti CD 4 . ^^^ This was the result of bispecific binding , because monovalent fragments of anti CD 4 and anti CD 26 were not able to modulate antigen or induce internalization using both a fluorescent assay and an 125I internalization assay . ^^^ On preactivating the same cells , using phorbol myristate acetate ( PMA ) / ionomycin on concanavalin A ( ConA ) or especially PHA , levels of CD 26 were upregulated and the immunotoxin effectively inhibited the ability to provide help for B cell Ig synthesis while leaving intact the CD 4 CD26+ and CD4+CD26 populations ; an effect observed both functionally and by phenotype . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
A series of double labeling experiments revealed that BB 27 mAb identifies new CD 4 and CD 8 cell subsets different from those defined by CD45RA , CD45RO , CD 26 , CD 29 , CD 31 , and CD 38 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
We have studied the expression of several leukocyte surface markers ( CD 2 , CD 3 , CD 4 , CD 8 , CD 7 , CD 26 , CD 25 , CD 14 , CD 18 , kCD 20 , CD 43 , CD 45 , CD45R , CD 71 and HLA class 1 and 2 ) and we find no differences in their expression between PPL . 1 and its parental Jurkat cell line . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NKL cells express CD 2 , CD 6 , CD11a , CD 26 , CD 27 , CD 29 , CD 38 , CD 43 , CD 58 , CD 81 , CD 94 , CD 95 , class 2 MHC , and the C1 . 7 . 1 antigen , but do not express detectable levels of CD 3 , CD 4 , CD 5 , CD 8 , CD 14 , CD 19 , CD 20 , CD 28 , alpha / beta or gamma / delta T cell receptors on the cell surface . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Moreover , only CD 4 + CD45RC10 blast cells of HgCl 2 exposed rats showed decreased expression of CD 43 , increased expression of CD49d and decreased numbers of CD 26 + cells . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
The percentage of T cells expressing CD 25 and CD 26 varied no more than repeated estimation of the CD 4 T cell subset , whereas other actags showed greater variability . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Although Abs specific for CD 4 , CD 26 , CD 28 , CD 44 , CD45RA , or CD45RO were sufficient to activate T cells when co immobilized with anti CD 3 mAb , all were refractory to the inhibitory effects of mAb 18D3 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
In both of the experimental models used , no significant differences were observed between the transfected cells expressing either the wild type or the mutated form of CD 26 , thus suggesting that the DPP 4 activity of CD 26 is not essential for its function as a cofactor of CD 4 in the mechanism of initiation of apoptosis by the HIV envelope gp120 / gp41 complex . ^^^ Taken together , these results indicate that CD 26 in CD4+ T cells may determine the rate of initiation of apoptosis by the mature HIV 1 envelope glycoproteins , i . e . , CD 26 is being involved as a cofactor of CD 4 in the mechanism of triggering apoptosis by the gp120 / gp41 complex . ^^^ As signaling through CD 26 could lead to T cell activation , we propose that this latter might be modified following the binding of the gp120 / gp41 complex to CD 4 and thus leading to apoptosis . . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Furthermore , SA 1042 does not interfere with the binding of monoclonal antibodies directed to other molecules , gp 41 , CD 4 , CD11a , CD 18 , CD 26 , CD 44 or CD 54 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
On PHA activated , Fas sensitive T cell blasts , anti Fas mAb rapidly triggered downmodulation of a variety of antigens , including CD 2 , CD 4 , CD 8 , CD 7 , CD 44 , LFA1alpha , LFA1beta , and CD62L , but not CD 3 , CD 25 , or CD 26 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Primary mouse cells expressing human CD 4 and mouse 3T3 cells stably expressing both human CD 4 and human CD 26 did not support fusion with our Env expressing cells . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
In order to further define the expression and functional activity of CD 26 in the developing thymus , we utilized a nondisruptive , cytofluorogenic assay which allowed simultaneous measurement of DPP 4 activity with a fluorochrome conjugated peptide substrate and surface staining of the T lymphocyte lineage antigens CD 4 and CD 8 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
A two colour cytofluorometry was employed using monoclonal antibodies against Fas receptor ( CD 95 ) in combination with the surface markers CD 4 , CD 8 , CD 28 , CD 26 and CD45RO . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
We show that in human B and T cell lines , irrespective of CD 4 expression , 125I labeled ADA binding to CD 26 is inhibited by recombinant soluble HIV 1 envelope glycoprotein gp 120 and by HIV 1 infectious particles . ^^^ Accordingly , an anti CD 4 mAb , which inhibits the binding of gp 120 to CD 4 and blocks viral infection , did not affect inhibition of 125I labeled ADA binding to CD 26 by HIV particles . ^^^ These results provide indirect evidence for the interaction of gp 120 with CD 26 and indicate that a specific function of gp 120 is the inhibition of ADA binding to CD 26 in both CD4+ and CD 4 cells . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Role of CD 26 for CD 4 memory T cell function and activation . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
CD 26 is a lymphocyte cell surface antigen that is stimulated by interleukin 1 and serves with CD 4 as a coreceptor that interacts with the V 3 loop in gp 120 of human immunodeficiency virus . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Co capping showed that all four gp120s significantly potentiated CD 4 association with CD 3 , CD45RA , CD45RB , CD 38 , CD 26 , CD 59 and class 1 MHC molecules . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
We have reported that CD 26 could serve as a cofactor of CD 4 in HIV entry . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
In human B and T cell lines we show that , irrespective of CD 4 expression , 125I labeled ADA binding to CD 26 is inhibited by recombinant soluble HIV 1 envelope glycoprotein gp 120 and by HIV 1 infectious particles . ^^^ These results indicate that a specific function of gp 120 is the inhibition of ADA binding to CD 26 in both CD4+ and CD 4 cells . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
RESULTS : Resident microglia could clearly be defined by the flow cytometric phenotype CD45low CD 4 CD11b+ CD11chigh major histocompatibility complex ( MHC ) class II+ CD 26 CD 14 . ^^^ Microglia activation was observed in specimens from only six ( 35 % ) out of 17 HIV uninfected but all four ( 100 % ) HIV infected patients , defined strictly as any level of upregulation of CD 4 expression , to produce the phenotype CD45low / medium CD4low CD11b+ CD1 . 1Chigh MHC class II+ / +2 CD 26 CD 14 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
The significant selective loss of CD 26 expression observed in HIV+ patients is probably an early event after HIV infection and seems to occur even before CD 4 cell depletion . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
By using dual fluorescence analysis , IL 12 dependent CD 26 expression was found in both CD 4 and CD 8 ( previously CD26+ or CD 26 ) activated T cells and , moreover , the CD45RO percentage was unaffected . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Expression of CD 4 and CD 25 and sensitivity to MTX returned to near parental levels after removal of MTX from culture medium , whereas expression of CD 26 and MTX uptake were significantly increased . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
In order to further define the expression and functional activity of this membrane exopeptidase in human thymus , we utilized a nondisruptive , cytofluorogenic assay which allowed simultaneous measurement of intracellular DPP 4 activity using a fluorochrome conjugated peptide substrate with surface staining of plasma membrane associated T lymphocyte lineage antigens CD 4 and CD 8 , as well as CD 26 . ^^^ In this regard , CD 4 ( ) / CD8 ( ) thymocytes displayed the lowest DPP 4 activity and had higher activity than the smaller sized CD 26 ( + ) cells . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Low relative frequencies of CD 26 ( + ) CD 4 ( + ) cells in long term nonprogressing human immunodeficiency virus type 1 infected subjects . ^^^ Compared to patients in the early phase of infection , the only difference was a relatively lower frequency of CD 4 ( + ) cells expressing CD 26 among the LTNP . ^^^ Despite the long duration of infection , the LTNP exhibit a pattern similar to that of newly infected persons , with the exception of lower expression of CD 26 on CD 4 ( + ) cells . . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Immunophenotyping was performed assaying the following cell surface antigens : CD 2 , CD 4 , CD 8 , CD 14 , CD 20 , CD 26 , CD 29 , CD45R , CD 56 , and PMN . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Apoptosis did not occur after secondary signaling through some other receptors ( CD 26 , CD 4 , CD 45 , and HLA class 1 ) or in HIV exposed resting CD8+ lymphocytes signaled through the homing receptors . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
In students , who were reactors to psychological stress ( criterion based on changes in the Perceived Stress Scale , PSS ) , but not in stress non reactors , a significant increase in the number of neutrophils , monocytes , CD 8 ( + ) , CD 2 ( + ) CD 26 ( + ) , and CD 2 ( + ) HLA DR+ T cells and CD 19 ( + ) B cells , and significant reductions in the CD 4 ( + ) / CD8 ( + ) T cell ratio were observed in the stress condition . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Among the cellular pathways activated by IL 12 , we had previously found that both the percentage and intensity of CD 26 ( + ) cells in the PHA stimulated T cells increased when IL 12 was present ( independently of its CD 4 or CD 8 phenotype ) . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Treatment resulted in a decrease in the concentration of myelin basic protein , a decrease in the serum concentration of immunoglobulin G ( IgG ) and intrathecal IgG synthesis , an increase in the cerebrospinal fluid concentration of transforming growth factor beta 1 , and changes in the expression of CD 25 , CD 26 , and human leukocyte antigen DR ( HLA DR ) on CD 4 T cells . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
The HIV 1 gp 120 inhibits the binding of adenosine deaminase to CD 26 by a mechanism modulated by CD 4 and CXCR 4 expression . ^^^ To further characterize this mechanism , we studied ADA binding to murine clones stably expressing human CD 26 and / or human CD 4 , and transiently expressing human CXCR 4 . ^^^ In cells lacking human CXCR 4 expression , this gp 120 mediated inhibition of ADA binding to human CD 26 was completely dependent on the expression of human CD 4 . ^^^ These data suggest that the interaction of gp 120 with CD 4 or CXCR 4 is required for efficient inhibition of ADA binding to CD 26 , although in the presence of CXCR 4 the interaction of gp 120 with CD 4 may be dispensable . . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Furthermore , CD 4 ( + ) CD 7 ( ) cells express the CD15s antigen but lack expression of CD 26 and CD49d . ^^^ Monitoring of circulating T cells with the CD 4 ( + ) CD 7 ( ) CD15s ( + ) CD 26 ( ) CD49d ( ) phenotype proved to be useful for the identification of clonal T cells in patients with SS . . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Thus , CD 26 codistributes with CXCR 4 , and both coimmunoprecipitate from membranes of T ( CD 4 ( + ) ) and B ( CD 4 ( ) ) cell lines . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
An increased CD4 / CD8 ratio and lower surface expression of CD 4 in tumor cells also helped separate the CD 26 / dim atypical population for quantification . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
The frequency of cells expressing activation markers CD 26 , CD 28 , CD 69 , and HLA DR was enhanced in AV2S3 positive versus AV2S3 negative BAL CD 4 ( + ) T cell subsets . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Parameters of cellular and humoral immunity ( differential blood count , T cell markers CD 2 , CD 3 , CD 4 , and CD 8 , B cell markers CD 19 and CD 20 , monocyte markers CD 13 and CD 14 , NK ( natural killer ) cell marker CD 16 , activation markers CD 25 , CD 26 , CD 69 , and HLA DR , and cytokines IL 1 receptor antagonist ( IL 1RA ) , IL 2 , soluble IL 2 receptor ( sIL 2R ) , IL 6 , IL 10 , and TGFbeta ) were measured in venous blood . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
The numbers of T lymphocytes and T cell subsets ( CD 2 ( + ) , CD 3 ( + ) , CD 4 ( + ) , CD 8 ( + ) ) , activated T cells ( CD 26 ( + ) ) , B cells ( CD 19 ( + ) ) , granulocytes ( CD 15 ( + ) ) and natural killer cells ( CD16 / 56 ) were monitored by flow cytometry in 79 kidney transplant recipients , 35 of whom had cytomegalovirus infection . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
The number of CD 3 ( + ) , CD 4 ( + ) , CD 8 ( + ) , CD 25 ( + ) , CD 71 ( + ) and CD 26 ( + ) lymphocytes was also evaluated . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
However , in their spleen lymphocyte population the percentage of CD 4 ( + ) T cells is lower , and that of NK cells is higher , than that in CD 26 ( + / + ) mice . ^^^ In their peripheral blood , CD 26 ( / ) mice present a conspicuously decreased proportion of CD 4 ( + ) NKT lymphocytes . ^^^ These results indicate that CD 26 contributes to the regulation of development , maturation and migration of CD 4 ( + ) T , NK and NKT cells , cytokine secretion , T cell dependent antibody production and immunoglobulin isotype switching of B cells . . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Parameters of cellular and humoral immunity ( differential blood count , T cell markers CD 2 , CD 3 , CD 4 , and CD 8 , B cell markers CD 19 and CD 20 , monocyte markers CD 13 and CD 14 , NK cell marker CD 16 , activation markers CD 25 , CD 26 , CD 69 and HLA DR , and cytokines IL 1 receptor antagonist ( IL 1RA ) , IL 2 , soluble IL 2 receptor ( sIL 2R ) , IL 6 , IL 10 , and TGFbeta ) were measured in peripheral venous blood . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Upon in vitro stimulation with paratuberculosis antigens , CD 4 ( + ) cells from infected calves proliferated , produced IFN gamma , and increased expression of CD 26 and CD45RO ( indicative of an activated memory phenotype ) . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Peripheral blood lymphocytes were double stained for CD 4 or CD 8 , as well as CD11a , CD 25 , CD 26 , CD 29 and CD45RA or the chemokine receptors CCR 3 , CCR 4 , CCR 5 or CXCR 3 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
The systemic ( peripheral blood ) and local ( decidua ) percentages of CD 4 ( + ) , CD 8 ( + ) , CD 26 ( + ) and CD 56 ( + ) cells as well as the number of Th 1 lymphocytes ( CCR 5 ( + ) cells ) were assessed in samples from women after SAs ( n = 20 ) and from women with normally progressing pregnancies ( NPs ) ( n = 27 ) using flow cytometry and immunohistochemistry . ^^^ We could not find any difference in the number of CD 4 ( + ) , CD 8 ( + ) , CD 26 ( + ) , CD 26 ( + ) / CD4 ( + ) or CD 8 ( + ) / CD26 ( + ) blood cells between NP and SA patients . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Eight of the 14 acute encephalitis patients recovered fully , and reductions in the percentages of CD 4 ( + ) CD 29 ( + ) helper inducer T cells and IL 2 receptor positive CD 4 ( + ) cells were associated with early recovery and favorable outcome , respectively , whereas a low percentage of CD 4 ( + ) CD 26 ( + ) memory T cells during an acute stage was associated with an unfavorable outcome following adjunctive intravenous corticosteroid treatment . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
CD 4 ( + ) T cells with a memory phenotype ( CD45R0 ( + ) ) expressing CD 25 and CD 26 were the predominant cell type responding to antigens . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Mycosis fungoides ( MF ) and Sezary syndrome ( SS ) are the most common types of CTCLs and are characterized by malignant CD 4 ( + ) / CLA ( + ) / CCR4 ( + ) T cells that also lack the usual T cell surface markers CD 7 and / or CD 26 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
The difference and similarity between bovine activated CD 8 ( + ) T cells ( CD 8 ( + ) CD 26 ( + ) ) and well established human CD 4 ( + ) CD 25 ( + ) T regulatory ( Tr ) cells may help to reveal their unique immune regulatory system in the host infected with S . aureus . . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Expression of CD 25 and CD 26 was increased ( P < 0 . 05 ) on CD 4 ( + ) , CD 8 ( + ) , and gammadelta T cell receptor positive cells . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
By contrast , HGMC did not express detectable amounts of CD 1 , CD 2 , CD 4 , CD 5 , CD 14 , CD 15 , CD 16 , CD 22 , CD 24 , CD 25 , CD 26 , CD 27 , CD 28 , CD 31 , CD 32 , CD 34 , CD 35 , CD 88 , or CD 116 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Peripheral lymphocytes from 7 patients with SS , 16 patients with mycosis fungoides ( MF ) and 11 healthy controls were analysed by flow cytometry for the expression of CD 4 , CD 7 , CD 26 , CLA and CCR 4 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
CD 26 + CD 4 + T cell counts and attack risk in interferon treated multiple sclerosis . ^^^ In interferon ( IFN ) beta treated patients , we found that the hazard ratio for developing an attack was 28 in patients with CD 26 + CD 4 + T cell counts above median , and this risk was independent of the risk conferred by neutralizing anti IFN beta antibodies . ^^^ CD 26 + CD 4 + T cell counts may identify patients with MS at increased risk of attack during treatment with IFN beta . . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
We previously demonstrated that stimulation of bovine peripheral blood mononuclear cells ( PBMCs ) with staphylococcal enterotoxin C ( SEC ) , led to an inversion of the CD 4 ( + ) : CD 8 ( + ) T cell ratio and generation of an atypical CD 8 ( + ) T cell subpopulation expressing CD 26 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Staining with Gly Pro MNA and Ala Pro MNA in alkaline buffer for DPP 4 was localized in some CD 4 and CD 8 positive T lymphocytes , CD 68 positive macrophages , and fibroblasts and these cells also reacted with the enzyme antibody . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
Polyclonal populations of alloreactive CD 4 and CD 8 T cells contained DPP 4 activity at 1 and 10 min of incubation that was variably elevated from resting T cells with the enzyme activity confined to CD26+ cells . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
We found normal human thymi to have notable differences in time dependent DPP 4 activity among the thymocyte subsets defined by their CD4 / CD8 phenotype , with CD 4 / CD8 thymocytes containing less DPP 4 activity than cells expressing CD 4 and / or CD 8 ( i . e . , maturing ) . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
The vast majority of DPP 4 positive T ALL cases expressed CD 4 , CD 8 , CD 7 , CD 5 , CD 2 along with CD 71 and CD 38 antigens , but the cells were surface membrane CD 3 antigen negative . ^^^ The phenotype of DPP 4 negative cases displayed membrane CD 3 antigen and variable expression of CD 4 and CD 8 . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
The variable CD 4 and / or CD 8 antigen expression , frequent CD 5 and CD 7 positivity and absence of surface membrane CD 3 antigen were the characteristic immunophenotypic features of CD26 / DPP 4 positive T lymphoblasts . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
The variable CD 4 and / or CD 8 antigen expression , frequent CD 7 positivity and absence of membrane CD 3 antigen expression were the characteristic immunophenotypic features of CD26 / DPP 4 positive T cells . ^^^
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P27487 and P01730	Pubmed	SVM Score :0.0
NA