Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
There was no significant difference in the distribution or intensity of ECM components , i . e . type 4 collagen , fibronectin and heparan sulfate proteoglycan , in glomeruli between the mAB CD 4 treated and the control ddY mice . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
As one approach to understand the molecular interactions that support HIV virion binding to human mucosal surfaces , we have examined the distribution of the primary HIV receptor CD 4 , the alternate HIV receptors heparan sulfate proteoglycan ( HS ) and galactosyl ceramide ( GalCer ) and the co receptors CXCR 4 and CCR 5 in palatine tonsil . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
These changes were accompanied by significant differences in the expression of the cell surface markers CD 4 ( HIV gp 120 receptor ) , CD 44 ( hyaluronate receptor ) , and KS 1 ( adenocarcinoma / epithelial specific antigen ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
These early precursors express CD 44 ( Pgp 1 ) , however , they are negative for expression of Thy 1 , CD 4 , CD 8 , CD 3 , membrane immunoglobulin and HSA cell surface molecules . . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The staining pattern of Th 5 in the thymus was apparently different from those with other T cell markers ( Thy 1 , CD 3 , CD 4 , CD 5 , CD 8 ) including J11d , Pgp 1 , IL 2R , and 3A10 ( TCR gamma delta ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The following were revealed : 1 ) the MRL104 . 8a monolayer failed to induce the differentiation of a Pgp 1+IL 2R subpopulation ; 2 ) whereas a Pgp 1 IL 2R+ subpopulation did not express either CD 4 or CD 8 Ag when cultured in medium , culturing this subpopulation on the thymic stromal cell monolayers resulted in the expression of CD 8 but not CD 4 Ag ; and 3 ) a Pgp 1 IL 2R DN subpopulation obtained through less extensive treatments with anti CD 4 and anti CD 8 antibodies in the presence of C before sorting procedures spontaneously differentiated into double positive cells in medium . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Indeed , subsequent analyses of subsets of CD 4 CD 8 cells , characterized by expression of HSA , Pgp 1 , and IL 2R , demonstrated that CD 4 CD 8 cells expressing IL 2R and their postulated progeny were reduced in IL 2 treated cultures . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
By 5 d , most of these Pgp 1 IL 2R alpha precursor cells have become CD3hi , and have lost or are downregulating either CD 4 or CD 8 . ^^^ In culture , these Pgp 1 IL 2R alpha cells also acquire high levels of CD 4 and CD 8 within 1 d , and low levels of CD 3 by 2 d . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The most mature cells in this sequence ( surface phenotype heat stable antigen ( HSA ) ++ Pgp 1 IL 2R alpha ) are the immediate precursors to CD4+CD8+ small cortical thymocytes , and have by definition been considered to be CD 4 CD8 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Flow cytometric analysis of lymphocyte populations from lymphomas in six recipients revealed that , while all lymphomas expressed phenotypic markers of immature cortical thymocytes , i . e . , Thy 1 , Pgp 1 , Jlld , and CD 5 , they were not uniform with regard to other T cell markers , notably CD 4 and CD 8 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Within 2 3 months of culture a cell population was selected in which the expression of Thy 1 antigen persisted , CD 4 and CD 8 antigens gradually declined , and Pgp 1 antigen , found on less than 5 % of fresh thymocytes , was strongly increased . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In contrast , DxS had little or no effect on the binding of anti CD 3 , CD 4 , CD 8 , Pgp 1 and WT 31 ( TCR alpha / beta ) mAb . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Virtually all cells of the most mature of the CD 4 CD8 thymocyte subpopulations ( other surface markers CD 3 HSA++ IL 2R Pgp 1 ) and of the immature CD 4 CD8+ thymocyte subpopulation ( other surface markers also CD 3 HSA++ IL 2R Pgp 1 ) became CD4+CD8+ in less than 1 day of culture without added stimuli or growth factors . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The expression of the alpha beta T cell receptor , CD 3 , CD 4 , IL 2 receptor ( p 55 ) , LFA 1 , Thy 1 , and Pgp 1 ( CD 44 ) was normal . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Cell sorting and cytotoxic depletion procedures were used to subdivide the population of CD 4 CD 8 ( `` double negative ' ' ) thymocytes from adult CBA mice on the basis of expression of Ly 1 , HSA ( the `` heat stable antigen ' ' M1 / 69 or B2A2 ) , Pgp 1 glycoprotein , Thy 1 , MEL 14 and the PC 61 antigenic determinant on the IL 2 receptor ( IL2R ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Some of the major sheep antigens , including CD 5 , CD 4 , CD 8 , SBU T 19 , Pgp 1 , LCA and the MHC antigens , are described in detail . . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Most clones express Thy 1 , Pgp 1 , ICAM 1 , HSA and B 220 antigen , but are negative for LFA 1 , CD 2 , Mel 14 , Fc receptor , Mac 1 , CD 4 and CD 8 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Pgp 1 expression was studied as a marker of memory / activation on systemic and mucosal T cells of BALB / c and C57BL / 6 mice after infection with respiratory syncytial virus ( RSV ) , using two color dual fluorescence flow cytometry employing anti L3T4 ( CD 4 ) , anti Ly 2 ( CD 8 ) , and anti Pgp 1 ( CD 44 ) monoclonal antibodies . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The differences in the homing characteristics of CD 4 and CD 8 cells among NOD , BALB / c , and C57BL / 6 mice were not related to modifications in the level of expression of adhesion molecules such as MEL 14 , LFA 1 , and Pgp 1 . . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
With regard to peripheral lymphocytes , the proportion of CD 4 and CD 8 cells expressing Mel 14 was decreased in the infiltrated islets , whereas the expression of LFA 1 , Pgp 1 , and LPAM 1 / 2 was increased . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Flow cytometry analysis of joint cells isolated after collagenase digestion from arthritic mice demonstrated that 13D5 injection induces the accumulation of CD 4 , CD 8 , PgP 1 ( CD 44 ) + cells within arthritic joints , whereas arthritic joints from mice injected with control hamster IgG contained cells with a CD4+ , CD 8 phenotype . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
We examined the effects of anti Pgp 1 ( CD 44 ) antibody on the in vitro deletion of murine CD 4 and CD 8 single positive T cells induced by Staphylococcal enterotoxin B ( SEB ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Within the subpopulation of double negatives expressing high levels of the heat stable antigen , the additional markers phagocytic glycoprotein 1 ( Pgp 1 ) and interleukin 2 receptor ( IL 2R ) can be used to define the sequence IL 2R Pgp 1+ IL 2R+ Pgp 1 IL 2R Pgp 1 , which occurs before the expression of CD 4 and CD 8 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The relationships between cell proliferation and cell differentiation during thymus ontogeny were studied by labeling DNA synthesizing thymocytes with bromodeoxyuridine and staining with antibodies against CD 4 , CD 8 , J11d , phagocytic glycoprotein 1 , TCR 5 beta 8 chain , Thy 1 , and IL 2R surface proteins . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The aggregation responses were completely inhibited by low temperatures , cytochalasins B and E , and partly inhibited by EDTA and CD 18 moAbs , but unaffected by aphidicolin , mitomycin C , an adenylate cyclase inhibitor ( 2 ' 5 ' dideoxyadenosine ) , and moAbs against other adhesion molecules ( CD2 / CD58 [ LFA 3 ] , CD28 / CD28 ligand B 7 , CD 4 , and CD 44 ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Cell surface molecules other than CD 4 , including TCR , CD 3 , CD11a , CD 2 , CD 45 , CD 44 , and MHC class 1 , remained identical on D10H and D10L sublines as on D 10 wild type cells . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Correlation of IL 2R , CD 44 and beta 4 on CD 4 CD 8 thymocytes revealed maximal levels on the intermediate CD 44 IL 2R+ subset . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In contrast , 7 to 50 % of mAb to CD 2 , CD 4 , CD 8 , CD11a / CD18 , CD 44 , and class 1 MHC molecules were resistant to detergent solubilization , demonstrating that a fraction of these molecules was constitutively associated with the cytoskeleton . ^^^ In addition , cross linking increased the fraction of CD 2 , CD 4 , CD 8 , CD11a / CD18 , CD 44 , and class 1 MHC molecules that was associated with the cytoskeleton . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In addition , CD4+ , CD 4 dull+ Ly 5 ( B 220 ) + , and DN T cells were examined for expression of CD 3 epsilon , TCR alpha / beta heterodimers , Ly 6C , and CD 44 and for proliferative responses to immobilized anti TCR mAb and cofactors . ^^^ In addition , CD 4 dull+ Ly 5 ( B 220 ) + cells closely resembled DN T cells in size and expression of TCR alpha / beta , CD3epsilon , CD 44 , and Ly 6C . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
We also studied the expression of the memory marker CD 44 on the CD45RA subsets of CD 4 and CD 8 cells , as well as the effect of in vitro activation on expression of CD45RA . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Peripheral T lymphocyte depletion by apoptosis after CD 4 ligation in vivo : selective loss of CD 44 and ' activating ' memory T cells . ^^^ The anti CD 4 induced depletion selectively removed CD 44 T cells . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
This population expresses low levels of CD 4 , very high levels of CD 44 and has a surface antigenic phenotype similar to that of bone marrow hemopoietic stem cells . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Both CD 4 and CD 8 T cells are included in the HA binding population which is strongly CD 44 positive . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In the present work , we have used cells of the CD 4 positive , CD 44 negative human T lymphoblast cell line Jurkat to study the role of CD 44 in HIV 1 infection and tropism . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In the absence of gp 120 , CD 4 displayed high association with CD 3 , CD 5 , CD45RC , CD 25 , CD 28 , CD 44 , and CD 53 ; weak association with CD 2 , CD 38 , CD45RB , CD62L , and CD 26 ; and no association with CD45RA , CD45RO , CD11b , CD11a , CD 54 , CD 7 , CD 48 , CD 98 , CD 59 CD55 , HLA class 1 and class 2 molecules . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
We have explored age related alterations in CD 44 and MEL 14 expression by spleen cells bearing the Thy1 . 2 , CD 4 or CD 8 antigens in C57BL / 6 mice at 2 , 8 , 15 and 23 months of age . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
After isolation of lymphocytes by gradient centrifugation , flow cytometric immunophenotyping was performed using CD 2 , CD 3 , CD 4 , CD 8 , CD11 / CD18 , CD 20 , CD 44 and MHC 2 monoclonal antibodies . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The TCR alpha beta + CD 4 CD 8 T cells showed an activated T cell phenotype ( L selectin CD 44 + ) and expressed CD45 / B220 and interleukin 2 receptor beta , but did not express heat stable antigen , which is expressed by the immature CD 4 CD 8 thymocytes . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
CD 4 , CD 8 and CD 3 were used to divide the populations into the conventional major categories , and the distribution of CD1a , CD 2 , CD 7 , CD 34 , CD 44 , class 1 MHC and class 2 MHC was then determined . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Activities found in four lots each of horse ATG ( ATGAM , Upjohn ) , rabbit and horse ATG ( thymoglobulin and lymphoglobulin , Merieux ) , horse ALG ( Minnesota ) , and rabbit ATG ( Fresenius ) have been compared for CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD11a , CD 18 , CD 28 , CD 44 , CD 45 , and TCR alpha / beta antigens . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Also , both trophoblast and decidual cells caused no significant changes in the expression of Thy 1 , CD 5 , CD 4 , CD 8 , CD 3 , CD 25 , CD 44 , and L selectin by the thymocytes . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Flow cytometric analysis revealed that these cells were CD 3 , CD 4 , CD 8 , and B 220 , but strongly expressed CD 45 ( leukocyte common antigen ) , and mild to moderate levels of CD11b , heat stable antigen , and CD 44 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Analysis of cells in culture with Alamar Blue for various surface antigens ( CD 44 , CD45RB , CD 4 , heat stable antigen ) by flow cytometry revealed that the fluorescent profile and relative percentage of cells in cultures with the Alamar Blue were comparable to those without this reagent . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
With peripheral blood derived T cells as a model , flow cytometric analysis revealed strongly reduced expression of distinct CD molecules for each enzyme , notably CD 2 , CD 4 , CD 8 and CD 44 for DNase , and CD 4 , CD 14 , CD 16 , and CD 56 for collagenase . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
PBK 101 was a thymic T cell line of AKR / J origin that expressed Thy 1 , CD 44 , IL 2R , and VLA 4 antigens but not CD 4 , CD 8 , or the TCR / CD3 complex . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Transfectants expressing CD 4 , CD 5 , CD 8 , CD 25 , CD 44 , two different WC 1 gene products and a transfectant expressing an unknown gene product were isolated using these techniques . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Multiparameter flow cytometry was used to analyze the array of immature phenotypes present in the SCID thymus at steady state , as defined by the markers CD 4 , CD 5 , Sca 1 , NK1 . 1 , CD 44 , heat stable antigen ( HSA ) , and IL 2R alpha . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The inability of LOA to present superantigen is not due to a structural difference in MHC 2 molecules between LOA and the splenic APC or to differential expression of major accessory / adhesion molecules , including CD 2 , CD 5 , CD 4 and CD 44 , on LOA . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
We tested CEMx 174 cells , which are CD 4 positive and HIV susceptible for phorbol ester inducible binding to hyaluronic acid through CD 44 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
There are several significant changes in the expression levels of alpha 4 and alphaM290beta7 integrins , CD11a , ICAM 1 , CD45RB , CD 4 , CD 44 , and CD 45 in different lymphocyte populations . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Seventy six percent of the CD 4 ( + ) T cell population increased in volume by day 7 post infection and expressed T cell maturation markers ( CD 44 ( hi ) , IL 2Rhi , Mel 14 ( lo ) ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Infiltrating mononuclear cells expressed CD11a ( 68 % ) , CD 18 ( 73 % ) , CD11b ( 13 % ) , CD11c ( 21 % ) , CD 58 ( 13 % ) , CD 4 ( 44 % ) , CD 8 ( 17 % ) , CD62L ( L selectin ) ( 18 % ) , CD49d ( 38 % ) , CD49e ( 15 % ) , CD 2 ( 56 % ) , and CD 44 ( 77 % ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Although Abs specific for CD 4 , CD 26 , CD 28 , CD 44 , CD45RA , or CD45RO were sufficient to activate T cells when co immobilized with anti CD 3 mAb , all were refractory to the inhibitory effects of mAb 18D3 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
On the other hand , CD 4 ( ) CD 8 ( ) double negative ( DN ) thymocytes , most of which were arrested at the CD 44 ( ) CD 25 ( + ) stage similarly to those in zeta deficient mice , could not be promoted for differentiation into CD 4 ( + ) CD 8 ( + ) double positive thymocytes in these mice in spite of the fact that the expression of the transgene in DN thymocytes was higher than that of zeta in wild type mice . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The CD 3 , CD 4 , CD 8 triple negative thymic subset was composed almost entirely of the earliest population ( CD44+ , CD 25 ) , with the remaining maturational stages ( CD44+ , CD25+ ; CD 44 , CD25+ ; and CD 44 , CD 25 ) depleted . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Furthermore , SA 1042 does not interfere with the binding of monoclonal antibodies directed to other molecules , gp 41 , CD 4 , CD11a , CD 18 , CD 26 , CD 44 or CD 54 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In this case , the anti CD 4 mAb was the most effective , followed by the anti alpha 4 antibodies in most cases , whereas anti CD 44 showed less clear effects on the development of humoral responses . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
On PHA activated , Fas sensitive T cell blasts , anti Fas mAb rapidly triggered downmodulation of a variety of antigens , including CD 2 , CD 4 , CD 8 , CD 7 , CD 44 , LFA1alpha , LFA1beta , and CD62L , but not CD 3 , CD 25 , or CD 26 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Some of these TCR antagonistic analogues carrying relatively conservative amino acid substitutions partially activated the T cells to induce large increases in size and expression levels of CD 4 , CD11a ( LFA 1 ) , CD 28 , CD49d ( VLA 4 ) , and CD 95 ( Fas ) , and small increases in CD 25 and CD 44 expressions on the cell surface . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Groups of mice from both strains were killed at 3 , 5 , 10 , 15 , 30 , and 150 days after infection and lymphocytes were harvested from the peritoneal exudate cells ( PEC ) , spleen , intestinal epithelial lymphocytes ( IEL ) , lamina propria lymphocytes ( LPL ) , Peyer ' s patches , and mesenteric lymph node ( MLN ) and labelled with monoclonal antibodies to CD 3 , CD 4 , CD 8 , gamma delta TCR , CD 25 , and CD 44 for flow cytometric analysis . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Cells were analyzed from the arterial line before , at 5 , 10 , 15 , 30 , 90 and 240 min with a panel of 33 surface markers including antibodies towards CD 3 , CD 4 , TCR alpha / beta , CD 7 , CD 8 , CD11a c , CD 14 , CD 18 , CD 19 , CD 25 , CD 28 , CD 29 , CD 38 , CD 44 , CD49a e , CD51 / 61 , CD 54 , CD 56 , CD 58 , CD 62 , CD 106 , and HLA class 2 using single fluorescence analysis . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Among mature peripheral CD 4 T lymphocytes , the highly O acetylated cells are Mel 14 ( hi ) , CD 44 ( lo ) , and CD45R ( exon B ) hi , features typical of naive cells . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Interferons alpha / beta inhibit IL 7 induced proliferation of CD 4 CD 8 CD 3 CD44+ CD25+ thymocytes , but do not inhibit that of CD 4 CD 8 CD 3 CD 44 CD 25 thymocytes . ^^^ The IL 7 induced proliferation of CD 4 CD 8 thymocytes from T cell receptor ( TCR ) transgenic mice , the majority of which are CD3+ CD 44 CD 25 , was resistant to IFN alpha / beta mediated suppression . ^^^ In contrast , the addition of IL 7 markedly decreased the percentages of CD 4 CD 8 CD 3 CD 44 CD 25 cells , and IFN alpha / beta reversed the effect and increased the subpopulations of CD 44 CD25+ and CD 44 CD 25 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
As manifested by CD 69 upregulation , LPS injection stimulates both CD 4 and CD 8 ( + ) T cells , and , at high doses , stimulates naive ( CD 44 ( lo ) ) cells as well as memory ( CD 44 ( hi ) ) cells . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The early thymocyte developmental stages , based on CD 44 and CD 25 expression , revealed the CD 4 CD8 CD 3 triple negative compartment ( TN ) to be composed of almost entirely the earliest population ( CD44+CD25 ) with the remaining maturational stages depleted . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
BAL cells were harvested and stained with antibodies to the equine homologues of CD 5 , CD 4 , CD 8 , CD 44 , MHC 1 , MHC 2 and to equine IgG . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The CD 4 positive population , following CVS injection at the time of tumor rechallenge , displayed a pronounced increase in the proportion of T cells that were CD 18 bright , CD 44 bright , CD25+ , CD54+ , CD69+ or CD71+ in the lymph nodes . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In heatstroke , percentages of T ( CD 3 ( + ) / CD19 ( ) ) , T helper ( CD 4 ( + ) / CD8 ( ) ) , T inactive [ CD 3 ( + ) / human leukocyte antigen DR ] , CD11a+ , CD11c+ , and CD 44 ( + ) lymphocytes were significantly decreased , whereas percentages of T suppressor cytotoxic ( CD 8 ( + ) / CD4 ( ) ) , natural killer ( NK ; CD 3 ( ) / CD16 ( + ) or CD 56 ( + ) ) , CD 3 ( + ) / CD16 ( + ) or CD 56 ( + ) , and CD 54 ( + ) lymphocytes were significantly increased , compared with 11 normal controls . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Interestingly , in thymocytes from mice treated with a single dose of 50 micrograms / kg body wt of TCDD , there was a significant increase in the density of expression of CD 3 , alpha beta TCR , CD 44 , and IL 2R , and a decrease in the expression of J11d , CD 4 , and CD 8 molecules when compared to the control thymocytes . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In this study a chimeric CD4 / CD44 molecule , containing the extracellular domain of CD 4 and the transmembrane and cytoplasmic domains of CD 44 , was expressed in two CD44+ mouse T lymphoma cell lines , BW 5147 and T 28 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Flow cytometry showed that CD 44 expression of CD 4 T cells from the submandibular lymph nodes was downregulated , whereas that of Mel14+ was upregulated . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Although changes in some markers ( L selectin ) occurred independently of cell division , changes in other markers were either strictly related to cell division ( CD45RB ) or were a prerequisite to cell division ( CD 4 , CD 44 ) . . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In addition , the study demonstrated that changes in CD 44 and CD45RB expression previously observed in young infected mice proceeded in a similar fashion in old animals and , as would be predicted , that CD 95 ( hi ) expression was primarily associated with CD 4 T cells expressing the activated CD 44 ( hi ) CD45RBhi phenotype . . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Both cortical TEC subsets are also present in recombination activating gene 1 ( RAG 1 ( / ) ) and TCRbetaxdelta / thymi in which T cell development is blocked at the CD 4 ( ) CD 8 ( ) CD 25 ( + ) CD 44 ( ) pre T cell stage . ^^^ In contrast , K 8 ( + ) K 5 ( + ) TECs predominate in the thymi of human CD3epsilon transgenic mice in which thymocyte development is blocked at an earlier CD 4 ( ) CD 8 ( ) CD 25 ( ) CD 44 ( + ) stage . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Isolated IEL were stained for CD 4 , CD 8 , and CD 44 ( as a marker for memory T cells ) and flow cytometry was performed . mRNA was extracted from remaining IEL for cytokine expression . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
METHODS : Twenty five synovial cell lines were generated by interleukin 2 ( IL 2 ) expansion from synovial biopsies of patients with early SpA and RA , obtained from macroscopically inflamed synovial tissue by needle arthroscopy , and subsequently characterized by flow cytometry for CD 3 , CD 4 , CD 8 , L selectin , CD11a , CD 31 , CD 44 , and alpha4beta7 and alphaEbeta 7 integrin . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
By 4 to 6 wk of age , obvious blockades in the differentiation of CD 4 8 thymocytes are observed at two distinct stages ( CD44+ 25+ and CD 44 25 ) , both of which are normally characterized by extensive proliferation . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
These mice exhibited immune system activation as evidenced by increased expression of CD 44 on CD 4 ( + ) T cells ; increased mesenteric lymph node cell numbers ; and increased production of immunoglobulin A ( IgA ) , IgG 1 , and IL 12 p 40 from colon fragment cultures . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
METHODS : IEL and LPL were obtained from 18 CD patients and 20 controls by enzymatic extraction , and subsequently characterized by flow cytometry for CD 3 , CD 4 , CD 8 , CD 25 , LFA 1 alpha ( CD11a ) , CD 44 , alpha 4 and alpha E beta 7 integrin . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Classification of the T cells based on their differential expression of CD 45 and CD 44 showed that the phenotypically different populations of CD 4 and CD 8 cells exhibited a type 1 cytokine pattern at latency and that reactivation of latent tuberculosis was associated with a shift in cytokines produced by these populations to a type 2 cytokine response . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Cells expressing CD 4 , CD 8 , CD 18 , CD49d / CD29 , CD 44 , CD 54 , CD 80 , CD 86 , CD 106 , CD11b / CD18 or DNA breaks were stained in the pancreases of female or male scid / scid mice after adoptive transfer of lymphocytes from older than 12 week female nonobese diabetic ( NOD ) or Balb / c mice . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
We have studied the immune response of the host testis against experimental testicular teratoma in mouse by localizing adhesion molecules ( CD 106 , CD 54 , CD49d / CD29 , CD 44 , CD 18 , CD 8 and CD 4 ) , cytokines ( IL 2 , IL 4 , IL 6 , IL 10 and IL 12 ) , T cell costimulators ( CD 80 , CD 86 ) and the lipid antigen presenting molecule CD1d in the testis of 129 / SvJ mice with and without experimental testicular teratoma . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In support of this interpretation , we found that the accessory molecules CD 4 , CD 44 , and B 7 1 ( all of which are involved in T cell co stimulation ) were cleaved by Phlogenzym , while CD 3 and MHC class 2 molecules ( which are involved in the recognition of antigens by T cells ) and LFA 1 were unaffected . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Also , there is a dramatic increase in immature CD 44 ( + ) CD 25 ( ) cells , a decrease in the more mature CD 4 ( + ) CD 8 ( + ) cells , and development of an abnormal CD 44 ( + ) CD 8 ( + ) population . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Development of thymocytes can be staged according to the levels of expression of the cell surface markers CD 4 , CD 8 , CD 44 , CD 25 and CD 2 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
CD 44 signaling through p56lck involves lateral association with CD 4 in human CD4+ T cells . ^^^ We found that CD 44 cross linking by mAb in CD 4 ( + ) peripheral blood T cells promotes formation of a trimeric complex of Grb 2 , phospholipase ( PLC ) gamma 1 and a 36 38 kDa phosphoprotein , and the activation of PLC gamma 1 . ^^^ Co capping , co immunoprecipitation and fluorescence resonance energy transfer experiments showed that CD 44 associates with CD 4 and CD 3 on the cell surface . ^^^ This association suggests functional interplay between the CD 4 TCR complex and CD 44 . ^^^ In line with this possibility , we found that CD 4 triggering by gp 120 , a natural ligand of CD 4 , potentiates CD 44 mediated adhesion to hyaluronic acid . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
A small fraction of rat 13 day old fetal liver ( r13FL ) cells , which weakly expressed the leukocyte common antigen CD 45 , constituted a homogeneous Thy 1 ( hi ) , CD 71 ( ) , CD 44 ( + ) , MHC class I+ , CD 43 ( + ) cell subpopulation negative for CD45RC , CD 3 , TCRalphabeta , TCRgammadelta , CD 2 , CD 5 , CD 4 , CD 8 , CD 25 , CD 28 , NKR P1a and sIg . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Nave CD 4 ( + ) T cells ( CD 44 ( lo ) , CD45RB+ , CD62L+ ) die as a consequence of Fas ligation in the presence of anti CD 3 antibody , whereas memory T cells ( CD 44 ( hi ) , CD45RB , CD62L ) , freshly isolated from the same starting population and subjected to the same stimulation conditions , are costimulated to proliferate by Fas ligation . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Similar results were observed when CD 4 ( + ) T cells of naive phenotype ( CD 44 ( low ) , CD45RB ( high ) ) were used in the experiments . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Flow cytometry was used to examine the expression of CD 4 , CD 8 , T cell receptor gammadelta ( TCR gammadelta ) , TCR alphabeta , HLA DR , CD 44 , and interleukin 2 receptor on gut T lymphocytes . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
During adult thymus development immature CD 4 ( ) CD 8 ( ) [ double negative ( DN ) ] precursor cells pass through four phenotypically distinct stages defined by expression of CD 44 and CD 25 : CD 44 ( hi ) CD 25 ( ) ( DN 1 ) , CD 44 ( hi ) CD 25 ( + ) ( DN 2 ) , CD 44 ( lo ) CD 25 ( + ) ( DN 3 ) and CD 44 ( lo ) CD 25 ( ) ( DN 4 ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Treatment with allergens , but not irritants , resulted in a selective increase in the percentages of CD 4 ( + ) and CD 8 ( + ) cells expressing the T cell activation / memory phenotype CD62L ( lo ) CD 44 ( hi ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
We have identified a rare ( approximately 0 . 05 0 . 1 % ) population of cells ( Thy 1 ( hi ) CD 16 ( + ) CD 44 ( hi ) CD 2 ( ) TCRalphabeta ( ) B 220 ( ) M ac 1 ( ) NK 1 . 1 ( ) ) in the adult mouse bone marrow that generates CD 4 ( + ) and CD 8 ( + ) TCRalphabeta ( + ) T cells after tissue culture for 48 hr in the presence of Ly 5 congenic marrow cells . ^^^ The essential stages in the maturation of the progenitors were determined ; the stages included an early transition from CD 2 ( ) CD 16 ( + ) CD 44 ( hi ) TCRalphabeta ( ) to CD 2 ( + ) CD 16 ( int / ) CD 44 ( int / ) TCRalphabeta ( ) cells , and a later transition to CD 4 ( + ) CD 8 ( + ) TCRalphabeta ( + ) double positive T cells that rapidly generate the CD 4 ( + ) and CD 8 ( + ) single positive T cells . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Immunoprecipitation of T cell lysates with anti CD 9 mAb followed by immunoblotting with mAb against various T cell molecules showed the association of CD 9 with CD 3 , CD 4 , CD 5 , CD 2 , CD 29 and CD 44 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The CD 4 ( + ) CD 43 ( low ) subset exhibits a naive T cell phenotype , being CD62L ( high ) CD45RB ( high ) CD 44 ( low ) , whereas CD 4 ( + ) CD 43 ( high ) cells exhibit a memory phenotype , being CD62L ( low ) CD45RB ( low ) CD 44 ( high ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
While CD 4 ( + ) T cells under went a transient activation following immunization with gamma spz , CD 8 ( + ) T cells expanded robustly after spz challenge and exhibited stable expression of CD 44 ( hi ) and CD45RB ( lo ) during protracted protection . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
We show that p 56 ( lck ) transcripts are detectable in each CD 4 ( ) CD 8 ( ) double negative ( DN ) thymocyte subset defined by CD 25 and CD 44 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Further analysis showed no relation between E cadherin or CD 44 expression and the HPV status and CD 4 T cell serum levels . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Expression of CD 4 , CD 8 , CD 25 , CD 38 , L selectin , CD 44 , alphaEbeta 7 and alpha4beta7 were studied . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Moreover , CTX induced a long lasting increase in in vivo lymphocyte proliferation and in the percentage of CD 44 ( hi ) CD 4 ( + ) and CD 44 ( hi ) CD 8 ( + ) T lymphocytes . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
CD 3 ( epsilon ) transgenic mice , RAG ( null ) mice and RAG ( null ) bone marrow transplanted CD 3 ( epsilon ) transgenic mice , that the control point in lymphoid development where triple negative ( CD 3 ( ) , CD 4 ( ) , CD 8 ( ) ) thymocytes progress from CD 44 ( + ) CD 25 ( ) towards CD 44 ( ) CD 25 ( + ) , influences the development of epithelial cells , critically inducing the extra , third dimension in the organization of the epithelial cells in the cortex . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Moreover , the CD 4 ( + ) lymphocytes from these mice showed no evidence of activation as judged by lack of upregulated expression of CD 44 or CD 69 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Unexpectedly , several of the NK related molecules , together with certain other molecules including CD 2 , CD 3 , CD 4 , CD 32 , and CD 44 , were often expressed in a mosaic manner , even on freshly derived clones , indicating frequent switching in expression . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
DNA 35 immunization resulted in an increased activated / memory CD 4 ( + ) T cell response , with an accumulation of CD 4 ( + ) CD 44 ( hi ) CD45RB ( lo ) T cells and an increase in antigen specific IFN gamma production . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In Mycobacterium bovis Bacille Calmette Gurin ( BCG ) infected wild type mice , there was a large expansion of an activated ( CD 44 ( hi ) ) splenic CD 4 T cell population followed by a rapid contraction of this population to normal numbers . ^^^ These mice accumulated large numbers of CD 4 ( + ) CD 44 ( hi ) T cells that were responsive to mycobacterial antigens . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
IFN gamma KO mice accumulated 10 16 fold more activated CD 4 T cells ( CD 4 ( + ) CD 44 ( hi ) ) than wild type mice in the central nervous system during EAE . ^^^ CD 4 ( + ) CD 44 ( hi ) T cells in the spleen and central nervous system of IFN gamma KO mice during EAE showed markedly increased in vivo proliferation and significantly decreased ex vivo apoptosis compared with those of wild type mice . ^^^ IFN gamma KO CD 4 ( + ) CD 44 ( hi ) T cells proliferated extensively to antigen restimulation in vitro and accumulated larger numbers of live CD 4 ( + ) CD 44 ( hi ) T cells . ^^^ IFN gamma completely suppressed proliferation and significantly induced apoptosis of CD 4 ( + ) CD 44 ( hi ) T cells responding to antigen and hence inhibited accumulation of live , activated CD 4 T cells . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
T595B1 expressed CD 3 , T cell receptor ( TCR ) beta , TCR Vbeta 2 , CD 4 , CD 25 , CD45RB , CD 44 , LFA 1 , and ICAM 1 molecules on its cell surface and showed MHC class 2 1 E ( k ) restricted tumor antigen specific proliferation . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Analysis within the immature CD 4 ( ) 8 ( ) thymocyte subset further revealed an alteration in normal CD 44 and CD 25 subset distribution . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Indeed , a fraction of LACK specific CD 4 ( + ) T cells expressed a typical CD 62 ligand ( low ) CD 44 ( high ) CD45RB ( low ) phenotype in uninfected mice . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In all mice , the disease progression was accompanied by a marked accumulation in the lungs of activated CD 4 ( + ) ( CD 44 ( high ) / CD45RB ( low ) ) and CD 8 ( + ) ( CD 44 ( high ) / CD45RB ( + ) ) T cells capable of secreting IFN gamma and of activating macrophages for NO production and mycobacterial growth inhibition . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The expanded CD 4 ( + ) cell population expressed CD 25 ; however , in contrast to concanavalin A treated culture , delayed CD 44 expression was observed . . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In gut associated lymphoid tissues of wild type mice , only CP harbored a large population of c kit ( high ) IL 7R ( + ) CD 44 ( + ) Thy 1 ( + / ) CD 4 ( + / ) CD 25 ( low / ) alpha ( E ) beta ( 7 ) ( ) Lin ( ) ( Lin , lineage markers ) lymphocytes that included cells expressing germline but not rearranged TCRgamma and TCRbeta gene transcripts . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The development of thymocytes in the transgenic strain in which p 27 ( Kip 1 ) is most abundant ( p 27 Tg ( high ) mice ) appeared to be blocked at the CD 4 ( ) CD 8 ( ) CD 25 ( + ) CD 44 ( low ) stage . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
We show that in vivo thymic DC express E cadherin , CLA , CD 4 , CD 38 , CD 40 , CD 44 , and granulocyte macrophage colony stimulating factor R ( GM CSF R ; CD 116 ) but no CD1a . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
CD 4 ( + ) Thy 1 ( ) thymocytes express high levels of CD 3 , intermediate to high levels of heat stable antigen ( HSA ) , and low levels of CD 25 , CD45RB , CD 69 , CD 44 and CD62L . ^^^ High dose virus infection resulted in decreased HSA and increased CD 44 expression on CD 4 ( + ) Thy 1 ( ) cells relative to cells from naive mice . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Because there is no age associated decrease in the number of CD 44 ( + ) CD 25 ( ) CD 3 ( ) CD 4 ( ) CD 8 ( ) cells , this study investigated whether alterations in apoptosis within the TN pathway accounted for diminishing thymocyte numbers with age . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In N15tg RAG 2 ( / ) CD 2 ( / ) mice , thymic dysfunction is evident by 6 wk with a pre TCR block in the CD 4 ( ) CD 8 ( ) double negative thymocytes at the CD 25 ( + ) CD 44 ( ) stage . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Abundant numbers of in vivo activated ( CD 69 ( high ) CD 44 ( high ) CD 28 ( high ) ) NK 1 ( + ) and NK 1 ( ) CD 4 ( + ) T cells were isolated from the inflamed colonic lamina propria ( cLP ) of transplanted mice with IBD that produced large amounts of TNF alpha and IFN gamma but low amounts of IL 4 and IL 10 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Here we show that the thymic T progenitor cells ( CD 25 ( + ) CD 44 ( + ) c kit ( + ) CD 3 ( ) CD 4 ( ) CD 8 ( ) thymocytes , termed pro T cells ) from young adult mice that have yet to express TCRs can be subdivided based on interleukin 7 receptor ( IL 7R ) expression . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Lin ( ) TdT ( + ) early pro B cells are shown here to be CD 27 ( + ) AA4 . 1 ( + / ) Ki 67 ( + ) Ly 6C ( ) Ly 6A / Sca 1 ( Lo / ) Thy 1 ( ) CD 43 ( + ) CD 4 ( + / ) CD16 / 32 ( Lo / ) CD 44 ( Hi ) and similar in some respects to the `` common lymphoid progenitors ' ' ( CLP ) identified by others . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In these studies , infection of C57BL / 6 mice with Toxoplasma gondii resulted in increased expression of CD 44 on T cells , B cells , NK cells , and macrophages , and a small percentage of CD 4 ( + ) T cells express an activated form of CD 44 . ^^^ Administration of anti CD 44 to infected mice prevented the development of a CD 4 ( + ) T cell dependent , infection induced inflammatory response in the small intestine characterized by the overproduction of IFN gamma . ^^^ Together , these results identify a novel role for CD 44 in the regulation of IFN gamma production by CD 4 ( + ) T cells during infection and demonstrate a role for CD 44 in the regulation of infection induced immune pathology . . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Many donor CD 4 cells in SP , MLN , and LP expressed CD 44 and also expressed de novo the mucosal homing integrin alpha ( 4 ) beta ( 7 ) ( LPAM 1 ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
We have in this report studied the early T cell development in these mice and we show that the transgenic TCRalpha chain is expressed by precursor thymocytes already at the CD 3 ( ) CD 4 ( ) CD 8 ( ) ( triple negative , TN ) CD 44 ( + ) CD 25 ( ) stage of development . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The total number of thymocytes was profoundly reduced in the transgenic mice , whereas in the double negative ( CD 4 ( ) CD 8 ( ) ) thymocyte subset , in particular the CD 25 ( + ) CD 44 ( ) pre T cell population , it was significantly increased . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In Peyer ' s patches of treated mice , use of TCR Vbeta 6 , Vbeta 8 , and Vbeta 14 increased in CD 4 ( + ) CD 44 ( + ) T cells , compared with use in nontreated mice . ^^^ On the other hand , use of TCR Vbeta 1 and Vbeta 8 was enhanced in splenic CD 4 ( + ) CD 44 ( + ) T cells . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The lungs of memory immune mice contained CD 4 ( + ) and CD 8 ( + ) T cells with the cell surface phenotype characteristic of memory cells ( CD 69 ( low ) CD 25 ( low ) CD 44 ( high ) ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
A subpopulation of CD 4 ( + ) 5 beta 10 ( + ) T cells up regulates both CD 44 and GL 7 and expands significantly in response to initial priming in the majority of animals ( D 9 : 70 % ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
These comparisons suggest that only a minority of the TCR ( + ) CD8alpha alpha ( + ) intraepithelial lymphocytes ( IEL ) of the transgenic euthymic mice originate from hematopoietic precursors acquiring a TCR in the gut wall , while a majority of these CD8alpha alpha ( + ) IEL appear to be of thymic origin ( as were all TCR ( + ) CD8alpha beta ( + ) or CD 4 ( + ) in any location ) ; these last cells are released from the thymus as double negative thymocytes , which are at a more immature stage ( CD 44 ( + ) CD 25 ( + ) ) in female mice than in males ( CD 44 ( ) ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
These cells were CD 4 ( + ) CD 44 ( high ) and were present during immediate and long term immune responses of normal mice . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
We propose that the malignant cell transformation of LBC cells could coincide with the transition stage from late double negative , DN 3 ( CD 4 CD 8 CD44 / low , CD25+ ) or DN 4 ( CD 4 low , CD 8 / low , CD 44 , CD 25 ) to double positive ( DP : CD4+CD8+ ) stage of T cell development . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Failure of memory ( CD 44 high ) CD 4 T cells to recognize their target antigen in retina . ^^^ In contrast , this report asks if resting , Ag specific CD 4 ( + ) CD 44 ( + ) T cells can recognize Ag expressed in the retina . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Most IL 4 producing clones were derived from CD 4 ( + ) cells of naive ( CD 44 ( low ) or CD62L ( high ) ) phenotype and the great majority coproduced IFN gamma and IL 3 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Pre TCR / CD3 signals are essential for survival and maturation of ( CD 44 ( ) 25 ( + ) ) DN 3 thymocytes via the ( CD 44 ( ) 25 ( ) ) DN 4 stage to CD 4 ( + ) CD 8 ( + ) ( DP ) cells , a process termed beta selection . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
After infection , the majority of CD 4 ( + ) and CD 8 ( + ) splenocytes acquired an activated phenotype , as indicated by expression levels of CD 44 and CD62L . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Age associated thymic atrophy is not associated with a deficiency in the CD 44 ( + ) CD 25 ( ) CD 3 ( ) CD 4 ( ) CD 8 ( ) thymocyte population . ^^^ Age associated thymic atrophy has been proposed to be due to changes in both the thymic microenvironment and in the intrinsic properties of the early T cell progenitors , the CD 44 ( + ) CD 25 ( ) CD 3 ( ) CD 4 ( ) CD 8 ( ) cells . ^^^ We also demonstrate that in the presence of anti IL 7 , CD 44 ( + ) CD 25 ( ) CD 3 ( ) CD 4 ( ) CD 8 ( ) cells from young mice show reduced thymocyte development in fetal thymic organ cultures compared with controls . ^^^ The increased thymopoiesis seen in the old animals occurs in the sequential manner which would be anticipated for an agent working directly on the early stages , including the CD 44 ( + ) CD 25 ( ) CD 3 ( ) CD 4 ( ) CD 8 ( ) cells . . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Successive rounds of cell division were monitored using the cell division dye 5 ( and 6 ) carboxyfluorecein diacetate succinimyl ester and it was determined that the CD 4 ( high ) subpopulation comprised the expanding alloreactive T cells , which ultimately took on the phenotype of memory / effector T cells ( i . e . , CD 44 ( high ) , CD45RB ( low ) , CD 69 ( high ) , and CD 162 ( high ) ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In the present study , we demonstrate that CD62L ( + ) , CD 44 ( low ) and CD 4 ( + ) naive T cells from BALB / c mice are capable of producing significant amounts of IL 4 , while naive T cells from B10 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Mice that inherit the viable hypomorphic 17Rn5 ( 1989SB ) eed allele sustain a partial developmental block at or before the CD 4 ( ) CD 8 ( ) CD 44 ( ) CD 25 ( + ) stage of thymocyte differentiation . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
CD 4 ( + ) CD 44 ( ) naive T ( h ) 0 cells were differentiated preferentially either to T ( h ) l or T ( h ) 2 cells , depending on the presence of RMp or OMp during the initial 24 h of culture , from ovalbumin specific TCR transgenic mouse spleen cells in the presence of IL 2 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Most blood NK1 . 1 ( ) CD 4 ( + ) and CD 8 ( + ) T cells expressed the naive CD 44 ( int / lo ) CD62L ( hi ) CD45RB ( hi ) T cell phenotype typical of those in the peripheral lymphoid tissues . ^^^ In contrast , most marrow NK1 . 1 ( ) CD 4 ( + ) and CD 8 ( + ) T cells expressed an unusual CD 44 ( hi ) CD62L ( hi ) CD45RB ( hi ) phenotype . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Expansion of CD 44 ( hi ) CD62L ( low ) CD 4 ( + ) T cells in the lung occurred following aerosol and intravenous BCG immunizations , and the lymphocyte recruitment was proportional to the pulmonary bacterial load . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
However , thymocyte development , cell cycle , and survival were unperturbed by mNumb overexpression , even though transgenic Numb was expressed at an early stage in thymocyte development ( CD 4 ( ) CD 8 ( ) CD 3 ( ) cells that were CD 44 ( + ) CD 25 ( + ) or CD 44 ( ) CD 25 ( + ) ; double negative 2 / 3 ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The earliest intrathymic precursors were CD 4 ( lo ) CD 8 ( ) CD 25 ( ) CD 44 ( + ) c Kit ( + ) cells that expressed elevated levels of Notch 1 mRNA . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
No effects caused by oxygen tension or autologous plasma on expression of other surface antigens ( CD 4 , CD 8 , CD 44 , CD 95 ) were observed . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In the cryptorchid cryptepididymis CD 4 , CD 8 , CD 18 , CD 44 , CD 54 and CD 106 expressing cells were occasionally present in the connective tissue surrounding the epididymal tubule . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Results : In CIU patients compared to controls , it was found that ( 1 ) TNF alpha , IL 10 , MIP 1alpha and RANTES production was augmented and IL 2 and INF gamma reduced , and ( 2 ) CD 44 , CD11a and CD62L expression on CD 4 and CD 8 cells was augmented . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The accumulation of CD 4 ( ) CD 8 ( ) stage of thymocytes in 22 month old BXD mice was further identified to be associated with a developmental block between the CD 25 ( ) CD 44 ( + ) and the CD 25 ( + ) CD 44 ( + ) stages . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Transient CD 44 variant isoform expression and reduction in CD 4 ( + ) / CD25 ( + ) regulatory T cells in C3H / HeJ mice with alopecia areata . ^^^ CD 44 , however , is apparently not involved in the maintenance of the disease state , which is characterized by high cytokine expression levels , an increased number of CD 4 ( + ) and CD8+ cells , but a low level of CD 4 ( + ) / CD25 ( + ) suppressor cells . . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Results obtained revealed similar expression of CD 25 , CD 24 , CD 8 , CD 4 , C 18 and CD 44 , while differences in binding to hyaluronic acid ( HA ) were found . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The expression of CD 25 and high levels of CD 44 was initiated in the thymus during the development from CD 4 ( + ) CD 8 ( + ) to CD 4 ( + ) ; a large proportion of maturing CD 4 ( + ) thymocytes expressed both CD 25 and high levels of CD 44 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
By flow cytometry , we have defined three distinct patterns of cytoskeletal association ; constitutive , inductive , and mAb crosslink induced , and assigned human and bovine CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 18 , CD 19 , CD 44 , CD45RA , CD45RO , alphabeta TCR , gammadelta TCR , E selectin ligands , and L selectin surface antigens to one of these respective patterns . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In contrast to CD 122 ( hi ) cells , the CD 122 ( lo ) subset of CD 44 ( hi ) CD 8 ( + ) cells is IL 15 independent ; likewise , being CD 122 ( lo ) , CD 44 ( hi ) CD 4 ( + ) cells are IL 15 independent . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
CD 4 ( hi ) cells also expressed high levels of CD 44 , consistent with their status as activated T cells . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Our data suggest that termination of BMP2 / 4 signaling is necessary for differentiation of CD 44 ( + ) CD 25 ( ) CD 4 ( ) CD 8 ( ) double negative ( DN ) cells along the T cell lineage . ^^^ Neutralization of endogenous BMP 2 and BMP 4 by treatment with the antagonist Noggin promotes and accelerates thymocyte differentiation , increasing the expression of CD 2 and the proportion of CD 44 ( ) CD 25 ( ) DN cells and CD 4 ( + ) CD 8 ( + ) double positive cells . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Stimulation with PPD or PWM increased CD 25 and CD 44 mean fluorescence intensity ( MFI ) and decreased CD62L MFI on CD 4 ( + ) cells from infected animals . ^^^ In contrast to proliferation , activation induced apoptosis of CD 4 ( + ) cells resulted in a significant down regulation of CD 44 expression . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
CD 44 ( bright ) CD 4 T cells in neonates have a wide repertoire as judged by the distribution of Vbeta expression . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The enhanced expression of memory markers ( CD 44 and CD62L ( low ) ) on CD 4 ( + ) T cells of the d3tx mice was unaffected by CD40L mAb treatment . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Thus , the Dd zeta cytolytic cell was found not to be a conventional CD8+ CTL , but rather an unusual T lineage cell ( CD 3 CD5+Thy1 . 1+ ) that lacked alphabeta or gammadelta TCRs , as well as CD 4 and CD 8 coreceptors , but expressed surface markers strikingly similar to memory CTLs , including CD 44 , Ly 6C , and CD 122 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
CD45RB ( low ) , CD 69 ( high ) , CD 44 ( high ) and CD62L ( low ) , and belonged to a CD 4 ( + ) CD 8 ( + ) population expressing c kit , IL 7R and pTalpha characteristic of immature developing lymphocytes . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Adoptive transfer of CD 4 ( + ) CD62L ( low ) CD 44 ( high ) activated / effector T cells 24 h prior to ACI into RAG 1 ( / ) mice resulted in a significantly enhanced acute ACI that was comparable to ACI in the C57BL / 6 animals . ^^^ Adoptive transfer of CD 4 ( + ) CD62L ( high ) CD 44 ( low ) naive / non activated T cells did not increase ACI in the brains of RAG 1 ( / ) mice . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
We show that this mutation drives the generation of a pool of memory CD 44 ( high ) CD62L ( neg ) CD45RB ( neg ) CD 4 TCR transgenic T cells . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Reporter gene expression was detected in CD 4 ( + ) T cells bearing the activation markers CD 25 , CD 44 , and CD 69 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
However , the expansion of CD 3 ( ) CD 4 ( ) CD 8 ( ) triple negative T cell precursors at the CD 44 ( ) CD 25 ( + ) and CD 44 ( ) CD 25 ( ) stages , and CD 4 ( + ) CD 8 ( + ) double positive thymocytes was affected during embryogenesis in these mutants . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
It was also reported that CD 4 ( + ) T cells express higher levels of CD 44 in the airway than in peripheral blood of patients with allergic respiratory diseases . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
After mouse skin was transplanted , the expression patterns of activated T lymphocyte markers , CD 44 and CD45RB were analyzed along with T lymphocyte markers , CD 3 , CD 4 and CD 8 using flow cytometry . ^^^ Peripheral blood , which was sampled from the tail every other day from day 3 to day 15 was stained with anti CD 44 ( or CD45RB ) , anti CD 4 ( or CD 8 ) and anti CD 3 monoclonal antibodies simultaneously , and analyzed by 3 color FACS . ^^^ The proportion and the number of CD 44 ( + ) CD 3 ( + ) lymphocytes , CD 44 ( + ) CD 4 ( + ) lymphocytes and CD 44 ( + ) CD 4 ( + ) CD 3 ( + ) lymphocytes began to increase after day 7 , to peak on day 11 , and then to decrease , showing a significant difference . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Addition of 1 , 25 ( OH ) ( 2 ) D ( 3 ) inhibited proliferation of CD 4 ( + ) cells and decreased the expression of CD 44 on responding ( i . e . , proliferating ) CD 4 ( + ) and gamma delta TCR ( + ) cells . ^^^ CONCLUSION : These findings suggest that the production of 1 , 25 ( OH ) ( 2 ) D ( 3 ) by macrophages within tuberculous lesions would inhibit proliferation and CD 44 expression by co localized CD 4 ( + ) and gamma delta TCR ( + ) cells . . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Using flow cytometric staining of T cells for visualisation expression of CCR 7 in association with CD62L and CD 44 , a major population of CD 4 or CD 8 T cells expressing CCR 7 were found to be CD62Lhigh CD44low , which would suggest a nave cell phenotype . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In ADA deficient FTOCs initiated at day 15 of gestation , thymocyte development was arrested at the CD 4 ( ) CD 8 ( ) CD 44 ( lo ) CD 25 ( + ) to CD 4 ( ) CD 8 ( ) CD 44 ( lo ) CD 25 ( ) transition . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Spleen cells expressing CD 3 , CD 4 , CD 8 , CD 19 , Mac 3 , and CD 44 were all susceptible to tumor induced apoptosis . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In vitro stimulation demonstrated that pure CD 44 ( + ) CD 25 ( ) , CD 44 ( + ) CD 25 ( + ) and CD 44 ( + ) CD 25 ( + ) thymocytes respond to ActivinA , while the mature CD 4 ( + ) and CD 8 ( + ) SP thymocytes respond to TGF beta stimulation measured as enhanced phosphorylation of Smad 2 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
LY 411 , 575 decreased overall thymic cellularity and impaired intrathymic differentiation at the CD 4 ( ) CD 8 ( ) CD 44 ( + ) CD 25 ( + ) precursor stage . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Furthermore , apoptosis associated phenotypic changes were found in thymocytes of mice perinatally exposed to TCDD , characterized by an increase in expression of CD 3 , alphabetaTCR , IL 2R , and CD 44 , and a decrease in CD 4 , CD 8 , and J11d markers . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In the thymus , CD 4 ( + ) CD 8 ( ) CD 25 ( + ) cells were found to have a more mature phenotype than the corresponding CD 4 ( + ) CD 8 ( ) CD 25 ( ) cells with respect to expression of Thy 1 ( CD 90 ) , CD 53 and CD 44 , suggesting that CD 25 expression , and perhaps commitment to regulatory function , might be a late event in thymocyte development . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Shh is necessary for expansion of CD 4 ( ) CD 8 ( ) double negative ( DN ) thymocytes and for efficient transition from the earliest CD 44 ( + ) CD 25 ( ) DN population to the subsequent CD 44 ( + ) CD 25 ( + ) DN population and from DN to CD 4 ( + ) CD 8 ( + ) double positive cells . . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The ability of thymocytes to produce cytokines and express cytokine receptors is gradually reduced as they mature from the stage of CD 44 ( + ) CD 3 ( ) CD 4 ( ) CD 8 ( ) precursor cells to the stage of CD 3 ( lo ) CD 4 ( + ) CD 8 ( + ) cortical thymocytes ; in the latter stage both these capacities become completely blocked . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In the absence of CD 4 T cell help , a distinct subset of memory CD 8 T cells develops that remains CD62L ( low ) up to 1 year after infection and exhibits a CD 44 ( int ) CD 122 ( low ) phenotype . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
This is characterized by an increase in thymocytes with the early development stage phenotype of CD 25 ( ) CD 44 ( + ) CD 4 ( ) CD 8 ( ) in aged IL 12b ( / ) mice . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
APRIL ( / ) mice have normal T and B lymphocyte development , normal T and B cell proliferation in vitro , but increased numbers of CD 44 ( hi ) CD62L ( lo ) CD 4 ( + ) effector / memory T cells and increased IgG responses to T dependent antigens . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Using this method , we found the earliest thymocyte subset ( CD 4 ( ) CD 8 ( ) CD 25 ( ) CD 44 ( + ) ) to contain both IL 7 responsive and nonresponsive cells . ^^^ Transition through the next stages of development ( CD 4 ( ) CD 8 ( ) CD 25 ( + ) CD 44 ( + and ) ) was associated with responsiveness of all thymocytes within these populations . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Both CD 4 and CD 8 TILs were predominantly CD 44 ( High ) and expressed CD 25 , CD 69 , and CD 95 cell surface activation markers . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Measures of activation included changes in CD 4 , CD 25 , CD 44 , CD45RB , CD62L , CD 69 , caspase 3 activation , CFSE dilution , size , number of cells recovered , and cytokine production . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
A leaky block in the differentiation of CD 4 ( ) CD 8 ( ) CD 3 ( ) CD 44 ( ) CD 25 ( + ) ( TN 3 ) into CD 4 ( ) CD 8 ( ) CD 3 ( ) CD 44 ( ) CD 25 ( ) ( TN 4 ) cells was observed . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Effector CD 4 ( + ) T cells are known to express CD 44 ( hi ) CD62L ( lo ) surface phenotype . ^^^ In this paper we demonstrate that a population of CD 44 ( hi ) CD62L ( lo ) CD 4 ( + ) effectors generated in response to Mycobacterium bovis BCG or M . tuberculosis infection in C57BL / 6 mice is heterogeneous and consists of CD 27 ( hi ) and CD 27 ( lo ) T cell subsets . ^^^ In addition , CD 27 ( lo ) CD 4 ( + ) T cells uniformly express CD 44 ( hi ) CD62L ( lo ) phenotype . ^^^ We propose that CD 27 ( lo ) CD 44 ( hi ) CD62L ( lo ) CD 4 ( + ) T cells represent highly differentiated effector cells with a high capacity for IFN gamma secretion and antimycobacterial protection at the site of infection . . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Over 90 % of interferon gamma producing CD 4 T cells and > 85 % of CD 8 T cells expressed CD 44 ( hi ) phenotype . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Signaling through the pre TCR controls the differentiation of immature CD 4 ( ) CD 8 ( ) CD 25 ( + ) CD 44 ( ) [ double negative ( DN ) 3 ] thymocytes into CD 4 ( + ) CD 8 ( + ) double positive ( DP ) cells through the CD 4 ( ) CD 8 ( ) CD 25 ( ) CD 44 ( ) ( DN 4 ) stage . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Moreover , increased numbers of activated CD 4 ( + ) CD 44 ( high ) CD62L ( low ) cells in the lungs and draining lymph nodes suggested improved Ag presentation by the APCs . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Further studies showed that noncultured zetaKO mice CD 4 ( + ) T cells and thymocytes bore a unique memory cell like CD 44 ( high ) , CD62L ( low / neg ) phenotype . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Mice lacking an essential component of the pre TCR exhibit arrest at the ( CD 4 ( ) CD 8 ( ) ) ( CD 44 ( ) CD 25 ( + ) ) stage ( DN 3 ) of thymocyte development , and introduction of p 53 deficiency into those mice abrogates this arrest , resulting in transition to the ( CD 4 ( + ) CD 8 ( + ) ) double positive ( DP ) stage . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Spi B expression is acutely induced coincident with T cell lineage commitment at the CD 4 ( ) CD 8 ( ) CD 44 ( ) CD 25 ( + ) ( DN 3 ) stage of thymocyte development and is then down regulated as thymocytes respond to pre TCR signals and develop beyond the beta selection checkpoint to the CD 4 ( ) CD 8 ( ) CD 44 ( ) CD 25 ( ) ( DN 4 ) stage . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Compared with WT mice , infected CD1d deficient C57BL / 6 mice had higher frequencies and numbers of activated ( CD 44 ( high ) ) CD 4 ( + ) cells in mesenteric lymph nodes . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
LACK specific CD 44 ( high ) CD62L ( low ) CD 4 T cells accumulated in the draining lymph nodes and had characteristics of effector cells , secreting IL 2 and IFN gamma upon Ag restimulation . ^^^ Indeed , LACK specific CD 4 T cells with central memory features ( IL 2 ( + ) IFN gamma ( ) CD 44 ( high ) CD62L ( high ) cells ) accumulated in all peripheral lymph nodes of mice immunized with LACK pulsed dendritic cells and after tumor resection . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Relative to the pokeweed mitogen induced responses of CD 4 ( + ) cells from steers ( 5 to 6 mo of age ) , CD 4 ( + ) cells from 1 wk old calves showed decreased proliferative activity , delayed increase in CD 25 expression , and no demonstrable increase in CD 44 expression or decrease in CD62L expression . ^^^ Feeding calves an intensified milk replacer was associated with decreased proliferation of mitogen stimulated CD 4 ( + ) , CD 8 ( + ) , and gammadeltaT cell receptor ( + ) cells ; decreased CD 25 expression by mitogen stimulated CD 4 ( + ) and CD 8 ( + ) cells ; and decreased CD 44 expression by mitogen stimulated CD 8 ( + ) cells . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The expanded Valpha14i NKT cells retained the memory / activated ( CD 44 ( + ) CD 69 ( + ) CD62L ( ) ) and CD 4 ( + ) or CD 4 ( ) 8 ( ) double negative phenotypes but modulated or lost the classical NKT cell marker , NK1 . 1 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
The findings show for the first time in vivo and in fetal thymus organ culture ( FTOC ) that TGF beta is not required for thymocytes to differentiate along the entire pathway of thymic T cell development , as defined by the expression patterns of CD 4 , CD 8 , CD 25 , and CD 44 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In contrast , SEA / CFA immunized IL 12p35 ( / ) mice , able to make IL 23 but not IL 12 , developed severe lesions that correlated with high levels of IL 17 , low IFN gamma , and an expansion of activated CD 4 T cells with a CD 44 ( high ) / CD62L ( low ) memory phenotype . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Additionally , evaluation of CD 25 ( + ) and CD 44 ( + ) expression by thymocytes indicated that the decrease in the percentage of CD 44 ( + ) CD 25 ( + ) thymocytes was at least partially responsible for the decrease in the percentage of CD 4 ( ) CD 8 ( ) thymocytes in F ( 1 ) male mice . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
In benign lesions CD 4 5 6 was detected in 20 30 % of the ductal epithelial cells , while C 44 5 3 and CD 44 s were not expressed . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Preferential expansion of CD 8 ( + ) and partial inhibition in the increase of CD 4 ( + ) CD 69 ( + ) and CD 8 ( + ) CD 69 ( + ) in CD 4 ( + ) CD 44 ( + ) and CD 8 ( + ) CD 44 ( + ) and in the decrease of CD 8 ( + ) CD62L in Trypanosoma cruzi infected mice were also observed . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Early indices of both peripheral CD 4 and CD 8 T cell activation , including IFN gamma production and increases in CD 44 and CD11a expression , are attenuated in mast cell deficient ( W / Wv ) mice after myelin oligodendrocyte glycoprotein ( 35 55 ) priming when compared to WT animals . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
To date , whether CD 44 has a role in mediating CD 4 ( + ) polarized T helper 1 ( Th 1 ) and Th 2 lymphocyte interactions with the endothelium in vivo is yet to be determined . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Few CD 4 ( + ) and CD 8 ( + ) T cells expressed an activated phenotype ( CD 44 ( hi , ) CD 25 ( + ) , CD 69 ( + ) , CD62L ( lo ) , CD45RB ( lo ) ) at the sites of clonal expansion ( lymph nodes , spleen , and blood ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
After ALS treatment , CD 4 ( + ) CD 25 ( + ) T cells underwent proliferation and expressed a memory T cell marker , CD 44 . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Flow cytometry showed that the cells were CD 4 ( ) and CD 8 ( ) , but CD 44 ( + ) , CD 25 ( + ) and cytoplasmic CD 3 ( + ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
We previously showed that T cell development was inhibited beginning at the CD 4 ( ) CD 8 ( ) CD 25 ( + ) CD 44 ( low ) stage in ADA deficient FTOC initiated at day 15 of gestation when essentially all thymocytes are CD 4 ( ) CD 8 ( ) . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Memory like CD 44 ( high ) CD 4 T cells from unprimed transgenic mice and in vitro activated Th 1 effector CD 4 T cells accumulated to larger numbers than naive or Th 2 effector cells at 48 and 72 h . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Splenic CD 3 ( + ) , CD 4 ( + ) , CD 3 ( + ) CD 25 ( + ) , and CD 4 ( + ) CD 44 ( + ) counts were significantly increased in mice after lymphocyte transfer from IRI mice vs . mice with lymphocytes from sham mice . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
CNS 2 enhancer activity and initial IL 4 expression in CD 44 ( hi ) CD4+ T cells were abolished in mice with a CD 4 specific deletion of the transcriptional mediator of Notch signaling , Rbp j . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Cre mediated thymocyte specific ablation of c Myc in CD 25 ( + ) CD 44 ( ) thymocytes reduced proliferation and cell growth at the pre TCR checkpoint , resulting in thymic hypocellularity and a severe reduction in CD 4 ( + ) CD 8 ( + ) thymocytes . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
Splenocytes ex vivo were surface stained either with monoclonal anti CD 3 , anti CD 4 , anti CD 8 , or anti CD 44 antibodies or a two step biotin TLR 4 monoclonal antibody streptavidin FITC surface stain and results analyzed by flow cytometry . ^^^ There is a significant ( p < 0 . 05 ) increase in CD 44 ( memory ) CD 4 and CD 44 ( memory ) CD 8 T cells 14 days after burn injury and this is associated with a significant ( p < 0 . 05 ) increase of TLR 4 expression in both T cell populations . ^^^
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P16070 and P01730	Pubmed	SVM Score :0.0
NA