Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Due ti this basic need for information , we have studied diverse lymphocytic subpopulations in a normal population that serves as a reference group , using the following antigens : CD 3 , CD 4 , CD 8 , CD 20 , CD45RA , CD 25 , LAM 1 , CD 29 , CD11b and CD 23 . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
MAbs specific to other adherence molecules such as ICAM 1 , CD 2 , CD 58 , CD 4 , CD 8 , CD11b and LAM 1 did not affect leukocyte adherence in this model . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
B cells and both major T cell subsets ( CD 4 , CD 8 ) exhibited CAE of LECAM 1 expression , but the inhibitory effect of IL 4 on this response occurred only in the T cell populations . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The earliest T cell precursor population in the adult mouse thymus ( low CD 4 precursors ) may be divided into 85 % of cells expressing surface Mel 14 ( LECAM 1 , the lymphocyte homing receptor ) and 15 % of cells which are Mel 14 . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Our purpose was to assess the expression of cell membrane antigens ( CD 3 , CD 4 , CD1a , CD 36 ) , of adhesion receptors ( leukocyte function adhesion 1 , LFA 1 , endothelial leukocyte adhesion molecule 1 , ELAM 1 ) intercellular adhesion molecule 1 , ICAM 1 ) , and the intercellular relationships in the early phase of the disease . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
RESULTS : In actinic prurigo patients , there was a significant increase in the number of CD 3 , CD 4 , CD 8 , CD45RA , CD45RO , and CD45RB lymphocytes and Langerhans cells , as well as in the level of human leukocyte antigen DR ( HLA DR ) expression and cell adhesion molecules lymphocyte functional antigen 1 ( LFA 1 ) , intercellular adhesion molecule 1 ( ICAM 1 ) , and endothelial leukocyte adhesion molecule 1 ( ELAM 1 ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Unlike CD45R , expression of L selectin was not related to CD 4 T cell memory as judged by proliferation in transformation assays to soluble antigen . ^^^ Three colour immunofluorescent staining demonstrated four subpopulations of CD 4 and CD 8 T lymphocytes in peripheral blood mononuclear cells ( PBMC ) that were CD45R+ , L selectin+ ; CD45R+ , L selectin ; CD45R , L selectin+ ; CD45R , L selectin . ^^^ CD 4 ( 4 ) memory cells were CD45R and L selectin+ or L selectin . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
There were fewer Leu 8 ( L selectin ) + B and Leu 8+ CD 4 T cells among adherent cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Compared with controls , HIV infected children showed a slight but not significant decrease in the proportion of CD 4 cells that coexpressed CD45RA and L selectin ( mean of 83 vs 75 % for < 2 years of age , 76 vs 62 % for 2 3 years , 64 vs 56 % for > or = 4 years ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Entry of naive CD 4 T cells into peripheral lymph nodes requires L selectin . ^^^ In mice , naive but not memory CD 4 cells express L selectin . ^^^ To examine the role of L selectin in helper T cell migration , we studied the effects of in vivo administration of MEL 14 on CD 4 cell responses . ^^^ The data demonstrate that L selectin mediates extravasation of naive CD 4 cells into PLN and that its function can not be replaced by other homing receptors . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
These results are in contrast to recent reports that murine and ovine CD 4 memory cells do not express L selectin or recirculate through LN high endothelial venules . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Lymphocytes were also characterized for the expression of CD 4 and CD 8 T cell markers and , within each population , for the expression of activation markers ( CD 25 , CD 69 ) and adhesion markers ( CD 51 , CD 54 , CD11b , CD49e , L selectin ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The TCR alpha beta + CD 4 CD 8 T cells showed an activated T cell phenotype ( L selectin CD 44 + ) and expressed CD45 / B220 and interleukin 2 receptor beta , but did not express heat stable antigen , which is expressed by the immature CD 4 CD 8 thymocytes . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Furthermore , flow cytometric analysis of such cells accumulating in the spleens of intravenously infected 24 month old animals revealed that a large percentage of CD 4 cells initially had poor or negative expression of the cell surface markers L selectin and CD11a , molecules that may be important in the movement of T cells across inflamed endothelial blood vessel surfaces . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Results assessing CD 4 cells for expression of the L selectin ( Leu 8 ) molecule were similar to those for CD45RA . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Also , both trophoblast and decidual cells caused no significant changes in the expression of Thy 1 , CD 5 , CD 4 , CD 8 , CD 3 , CD 25 , CD 44 , and L selectin by the thymocytes . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The population of alpha 4 beta 7 hi CD 4 lymphocytes are enriched in Peyer ' s patches and form subsets of the memory CD4+ lymphocyte population , which can be further subdivided on the basis of alpha E beta 7 , L selectin and alpha 4 expression . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Infiltrating mononuclear cells expressed CD11a ( 68 % ) , CD 18 ( 73 % ) , CD11b ( 13 % ) , CD11c ( 21 % ) , CD 58 ( 13 % ) , CD 4 ( 44 % ) , CD 8 ( 17 % ) , CD62L ( L selectin ) ( 18 % ) , CD49d ( 38 % ) , CD49e ( 15 % ) , CD 2 ( 56 % ) , and CD 44 ( 77 % ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Whereas all CD31+ CD 4 T cells rapidly express high levels of the CD45RO antigen and down regulate the L selectin antigen after priming , CD 31 disappears more slowly because only part of the cells lose CD 31 expression upon each cycle of stimulation . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Since mouse memory CD 4 and CD 8 T cells are L selectin low , only migration of naive T cells is perturbed by the in vivo antibody blockade . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
L selectin is not essential for naive CD 4 cell trafficking or development of primary responses in Peyer ' s patches . ^^^ We showed previously that L selectin dependent recirculation of naive CD 4 cells is essential for development of primary responses in peripheral lymph nodes . ^^^ Here we show that anti L selectin antibody , MEL 14 , inhibited homing of a rigorously purified , homogenous population of naive CD 4 cells into both of these tissues as well as peripheral lymph nodes , directly demonstrating a role for this receptor in regulating entry into gut associated sites . ^^^ The results indicate that interactions with L selectin can be circumvented to allow entry of naive CD 4 cells into Peyer ' s patches but not peripheral lymph nodes . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Skin homing T cells were also quantified using antibodies to CD 3 , CD 4 , CD 8 , UCHL 1 , L selectin and the cutaneous lymphocyte antigen ( CLA ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
At least two intravascular monocyte subsets , probably central and marginating cells , were distinguished by their size and differential expression of CD 43 , CD 4 , CD11a , CD 18 , and L selectin . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Purification of L selectin ( low ) cells promotes the generation of highly potent CD 4 antitumor effector T lymphocytes . ^^^ Our results thus demonstrate that the purification of L selectin cells led to the generation of CD 4 immune effector cells with unusually high therapeutic efficacy against chemically induced tumors . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Flow cytometry was used to study the expression of CD 4 , CD 8 , CD 14 , CD 18 , WC 1 , MHCII , B cell and L selectin on CD45+ leukocytes in ovine blood and mammary secretions from lactating and dry ewes . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Serial frozen sections of grafts and controls were stained by immunoperoxidase for rat MAC 1 , class 2 MHC , CD 2 , CD 4 , CD 8 , B cells , VLA 4 , LFA 1 , L selectin , ICAM 1 , and VCAM 1 . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The number of memory cells ( CD45R0 ) dropped ( p < 0 . 02 for CD 4 and p < 0 . 004 for CD 8 ) and there was a loss of L selectin ( p < 0 . 003 for CD 4 and CD 8 ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
T lymphocyte populations , including CD 3 , CD 4 , CD 28 , and adhesion molecules ( L selectin , LFA 1 , VLA 4 , and ICAM 1 ) were measured by flow cytometry in a cross sectional study of 100 HIV infected and 49 HIV seronegative adults . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
RESULTS : At baseline , we found significant differences in the expression of CD 4 , CD 8 , and L selectin between peripheral blood T cells and tissue T cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Blockade of both L selectin and alpha 4 integrins abrogates naive CD 4 cell trafficking and responses in gut associated lymphoid organs . ^^^ We showed previously that blocking of only L selectin is sufficient to ablate trafficking of naive CD 4 cells and the development of their responses in peripheral lymph nodes but not in PP where alpha4beta7 integrins are thought to primarily regulate entry . ^^^ Since previous studies indicate that both alpha4beta7 integrins and L selectin regulate adhesion of naive cells to PP HEV , we examined the effect a blockade of both adhesion pathways on the recirculation of naive CD 4 cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Although changes in some markers ( L selectin ) occurred independently of cell division , changes in other markers were either strictly related to cell division ( CD45RB ) or were a prerequisite to cell division ( CD 4 , CD 44 ) . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Shedding of L selectin and up regulation of CD11b in response to in vitro stimulation with N formyl methionyl leucyl phenylalanine ( fMLP ) were less in HIV+ compared with HIV subjects , most markedly in subjects with CD 4 cell counts < 100 cells / mm3 . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
METHODS : Twenty five synovial cell lines were generated by interleukin 2 ( IL 2 ) expansion from synovial biopsies of patients with early SpA and RA , obtained from macroscopically inflamed synovial tissue by needle arthroscopy , and subsequently characterized by flow cytometry for CD 3 , CD 4 , CD 8 , L selectin , CD11a , CD 31 , CD 44 , and alpha4beta7 and alphaEbeta 7 integrin . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Migrated CD 4 ( + ) cells were predominantly CD 29 ( high ) / CD26 ( high ) , and within this subset uniformly expressed CD62L ( L selectin ) at an intermediate level . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Cryptococcal glucuronoxylomannan ( GXM ) , but not galactoxylomannan or mannoprotein , was found to cause loss of L selectin from freshly isolated human T cells of both CD 4 and CD 8 subsets and from Jurkat cells . ^^^ With the signaling pathway inhibitors staurosporine ( which inhibits protein kinase C ) and herbimycin A ( which inhibits protein tyrosine kinases ) , we showed that GXM or the cryptococcal culture filtrate antigen CneF directly induces L selectin loss from CD 4 ( + ) and CD 8 ( + ) T cells via a herbimycin A sensitive pathway ( s ) presumably involving one or more protein tyrosine kinases but not via a pathway involving protein kinase C . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Sorting for L selectin ( CD62L ) expression established that all virus specific CD 4 ( + ) T cells were initially CD62Llow , with > 80 % maintaining that phenotype for the next 14 months . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Examination of leukocyte cell surface antigens expressed by splenocytes revealed no statistically significant changes in the level of the T lymphoid antigens Thy 1 , CD 5 , CD 4 , CD 8 and CD 3 , the macrophage antigen Mac 1 , and the adhesion molecules LFA 1alpha , LFA 1beta and L Selectin , following GM CSF immunostimulation . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The expression of L selectin on B cells , monocytes , and neutrophils was significantly decreased in patients with AD compared with normal control subjects , although those on CD 4 ( + ) or CD 8 ( + ) T cells from patients with AD were similar to those from normal control subjects . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Ligation of the CD 4 receptor induces activation independent down regulation of L selectin . ^^^ Here , we show that ligation of CD 4 , without ligation of the T cell receptor for antigen , causes down regulation of L selectin on T helper cells . ^^^ Because CD 4 is a coreceptor for HIV 1 , the down regulation of L selectin induced by CD 4 ligation could play a role in the pathogenesis of AIDS . ^^^ We provide evidence that CD 4 ligation by HIV 1 induces metalloproteinase dependent L selectin down regulation . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Analysis of expression of molecules involved in adhesion indicated that in HAM patients , L selectin ( CD62L ) expression on CD 4 ( + ) and CD 8 ( + ) subsets was lower than in controls . ^^^ Interestingly , HAM patients had a lower percentage of CD 4 ( + ) subsets expressing L selectin than carriers ( P < 0 . 05 ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Expression of CD 4 , CD 8 , CD 25 , CD 38 , L selectin , CD 44 , alphaEbeta 7 and alpha4beta7 were studied . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Couples responded to the conflict task with cardiovascular reactivity ; increases in the percentages of circulating NK cells and CD 8 ( + ) T cells and decreases in the percentage of circulating CD 4 ( + ) T cells ; decreases in the percentage of NK cells that express L selectin ; and increases in NK cell cytotoxicity without a commensurate increase in per cell cytotoxicity . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Adenoids provide a microenvironment for the generation of CD 4 ( + ) , CD45RO ( + ) , L selectin ( ) , CXCR 4 ( + ) , CCR 5 ( + ) T lymphocytes , a lymphocyte phenotype found in the middle ear effusion . ^^^ It was found that most CD 4 ( + ) T lymphocytes in the middle ear effusion express the memory phenotype marker CD45RO and the chemokine receptors CXCR 4 and CCR 5 , but are negative for the lymphocyte homing receptor L selectin . ^^^ The results suggest that the adenoids provide a microenvironment for the generation for CD 4 ( + ) , CD45RO ( + ) , L selectin ( ) , CXCR 4 ( + ) and CCR 5 ( + ) T lymphocytes . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
We recently reported that the CD 4 ( + ) T cell subset with low L selectin expression ( CD62L ( low ) ) in tumor draining lymph nodes ( TDLN ) can be culture activated and adoptively transferred to eradicate established pulmonary and intracranial tumors in syngeneic mice , even without coadministration of IL 2 . ^^^ Isolated L selectin ( low ) CD 8 ( + ) T cells displayed the functional phenotype of helper independent T cells , and when adoptively transferred could consistently eradicate , like L selectin ( low ) CD 4 ( + ) T cells , both established pulmonary and intracranial tumors without coadministration of exogenous IL 2 . ^^^ Whereas adoptively transferred L selectin ( low ) CD 4 ( + ) T cells were more potent on a cell number basis for eradicating 3 day intracranial and s . c . tumors , L selectin ( low ) CD 8 ( + ) T cells were more potent against advanced ( 10 day ) pulmonary metastases . ^^^ Although the presence of CD 4 ( + ) T cells enhanced generation of L selectin ( low ) CD 8 ( + ) effector T cells , the latter could also be obtained from CD 4 knockout mice or normal mice in vivo depleted of CD 4 ( + ) T cells before tumor sensitization . ^^^ These data indicate that even without specific vaccine maneuvers , progressive tumor growth leads to independent sensitization of both CD 4 ( + ) and CD 8 ( + ) anti tumor T cells in TDLN , phenotypically L selectin ( low ) at the time of harvest , each of which requires only culture activation to unmask highly potent stand alone effector function . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
A subset of CD 27 ( neg ) memory CD 4 T cells from human peripheral blood is greatly enriched in the CCR 7 ( neg ) population , as well as L selectin ( neg ) cells , suggesting that these cells are incapable of homing to secondary lymphoid organs . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The frequency of L selectin ( + ) population among CD 8 ( + ) T cells was significantly decreased in SSc patients ( n = 30 ) compared with normal controls ( n = 20 ) , while that among CD 4 ( + ) T cells , B cells , monocytes , and neutrophils was similar for SSc patients and normal controls . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
HIV binding to , and signaling through , CD 4 and chemokine receptor molecules on resting CD 4 lymphocytes and other cell types [ which extensively occurs as the rare , productively infected cells ( ie : infected cells producing virus ) migrate among other cells through the lymphoid tissues back into the blood ] induces upregulation of L selectin and Fas . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
A population with homing potential for lymph nodes ( L selectin ( + ) CCR 7 ( + ) ) exists only within a small subset of CD 4 NKT cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
By flow cytometry , the number of lymphocytes , granulocytes , epithelial cells and red blood cells was analysed as well as the expression on lymphocyte subsets of the following antigens : CD 3 , CD 4 , CD 8 , CD 19 , CD 25 , CD 38 , CD45RO , CD45RA , HLA DR , TcRgd , CD 161 and l selectin . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
By flow cytometry , we have defined three distinct patterns of cytoskeletal association ; constitutive , inductive , and mAb crosslink induced , and assigned human and bovine CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 18 , CD 19 , CD 44 , CD45RA , CD45RO , alphabeta TCR , gammadelta TCR , E selectin ligands , and L selectin surface antigens to one of these respective patterns . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The process of nave CD 4 ( + ) T cell entry into lymph nodes correlates with cell surface expression of L selectin ( CD62L ) , which mediates early tethering and rolling events to endothelium prior to entry . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Furthermore , in contrast to recently described CD 4 ( + ) CD 25 ( + ) T ( S ) and plasmacytoid dendritic cell activated T ( S ) , tumor induced L selectin ( high ) T ( S ) prevent tumor rejection via blockade of sensitized , activated T ( E ) rather than via afferent blockade . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In these rats , the iris infiltrating cells consisted of a much higher percentage of CD 4 ( + ) T cells expressing L selectin ( CD62L ) than did those cells found in the spinal cord . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
METHODS : Leukocytes from 25 patients having gastric bypass surgery were compared to 15 normal controls preoperatively and at 1 , 3 , 6 , and 12 months postoperatively using flow cytometry to measure CD 3 , CD 4 , CD 8 , CD 56 , CD 62 ( L selectin ) , CD 69 , and CD 95 ( Fas antigen ) expression on T lymphocytes , B lymphocytes , natural killer cells , and neutrophils . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Two NKT cell subsets migrated in response to the lymphoid homing chemokine SLC / CCL21 : CD 4 ( ) Valpha14i negative NKT cells that were L selectin ( high ) and enriched for expression of Ly49G2 ( consistent with the phenotype of most NKT cells found in peripheral lymph nodes ) ; and immature Valpha14i positive cells lacking NK1 . 1 and L selectin . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Furthermore , stimulation of purified subsets of PBMC that express lymphocyte homing receptors demonstrated that RV specific INFgamma secreting CD 4 ( + ) T cells from adult volunteers preferentially express the intestinal homing receptor alpha4beta7 , but not the peripheral lymph node homing receptor L selectin . ^^^ In contrast , CMV specific INFgamma secreting CD 4 ( + ) T cells preferentially express L selectin but not alpha4beta7 . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
We have previously demonstrated that ligation of CD 4 by T cell tropic HIV 1 NL 4 3 induces metalloproteinase dependent L selectin ( CD62L ) shedding on resting CD 4 ( + ) T cells . ^^^ These results indicate that engagement of both CD 4 and CXCR 4 is required for HIV induced shedding of L selectin on primary resting CD 4 ( + ) T cells . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
CD 4 , CD 8 T cells and B cells were present in islet infiltrates from 9 week old L selectin sufficient and deficient littermates . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Although alpha ( E ) beta ( 7 ) ( + ) CD 4 ( + ) T cells possess a regulatory phenotype ( CD 25 ( + ) , L selectin ( lo ) , and CD45RB ( lo ) ) , express IL 10 , and suppress effector T cell proliferation in vitro , they can not prevent ileitis development in SCID mice adoptively transferred with effector CD 4 ( + ) T cells , although the CD 4 ( + ) CD 25 ( + ) subset , which overlaps with the alpha ( E ) beta ( 7 ) ( + ) CD 4 ( + ) subset , prevents colitis . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
We first show that diabetes onset is prevented in such mice by infusion of polyclonal CD 4 ( + ) T cells expressing L selectin ( CD62L ) but not prevented or only marginally prevented by CD 4 ( + ) CD 25 ( + ) T cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Flow cytometry was used to determine the expression of such adhesion molecules as L selectin ( CD62L ) , VLA 4 integrin ( CD49d ) , intracellular molecule ICAM 1 ( CD 54 ) and cytotoxic lymphocyte molecule CTLA 4 ( CD 152 ) , as well as the lymphocyte antigens : CD 3 , CD 4 , CD 8 , CD 19 , CD 1656 ( NK ) , CD 4 and CD 8 RO+ and RA+ . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
L selectin and beta 7 integrin on donor CD 4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft versus host disease . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
CD 4 ( + ) T cells from infected stomach expressed increased levels of the homing receptor L selectin and the chemokine receptor CCR 4 compared to CD 4 ( + ) T cells from uninfected stomach . ^^^ In conclusion , these results suggest that H . pylori specific CD 4 ( + ) T cells preferentially home to and accumulate in the infected stomach and that L selectin and CCR4 / MDC are important for this recruitment . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
METHODS : We investigated seasonal CD 4 memory T cell expression of the chemokine receptors CCR 4 , CXCR 1 as well as L selectin ( CD62L ) in fresh cultures derived from symptomatic atopics ( SAs ) , subjects with AS and healthy controls ( HCs ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Costaining for CR 1 and for the CD 4 subpopulation markers anti Leu 8 , TQ 1 , OKT 17 , 2H4 , and 4B4 indicated that CR 1 on lymphocytes may be coexpressed with any of these phenotypic determinants . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
To investigate whether the presence or absence of tissue eosinophilia is related to the immunophenotype of the T cells , we studied 43 cases of HD ( 28 nodular sclerosing , ten mixed cellularity , and five unclassifiable ) for the relative numbers of lymphocytes positive for CD 2 , CD 3 , CD 4 , CD 5 , CD 8 , CD 25 , CD 38 , T 9 , TQ 1 , HLA DR , and beta F 1 , and for the number of eosinophils in tissue sections . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Leucocyte subsets were enumerated with a panel of monoclonal antibodies which included CD 3 , CD 4 , CD 8 , TQ 1 , Leu 7 , CD 15 , HLA DR , CD 25 , CD 22 . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The T CLL cells coexpressed antigens detected by MAbs CD 2 , CD 3 , CD 4 , CD 5 , Ti ( TcR alpha / beta ; WT 31 ) CD 45 and CD45RA , but did not express any other antigens including CD 1 , CD 8 , CD 29 , and TCR gamma / delta , Ti gamma A and TQ 1 . ^^^ By the means of two color fluorescence , it was clearly demonstrated that the leukemic cells possessing CD 4 in the peripheral blood and cell cultures coexpressed CD45RA , but did not express either CD 29 or TQ 1 . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Whole blood samples were labelled with the nuclear dye LDS 751 and with antibodies to HLA DR or belonging to CD 2 , CD 3 , CD 4 , CD 7 , CD 8 , CD 10 , CD 13 , CD 14 , CD 19 , CD 20 , CD 29 , CD 33 , CD 45 , CD45RA , CD 56 , and CD62L ( TQ 1 ) that were directly conjugated to either phycoerythrin ( PE ) and / or fluorescein isothiocyanate ( FITC ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In the absence of gp 120 , CD 4 displayed high association with CD 3 , CD 5 , CD45RC , CD 25 , CD 28 , CD 44 , and CD 53 ; weak association with CD 2 , CD 38 , CD45RB , CD62L , and CD 26 ; and no association with CD45RA , CD45RO , CD11b , CD11a , CD 54 , CD 7 , CD 48 , CD 98 , CD 59 CD55 , HLA class 1 and class 2 molecules . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
On PHA activated , Fas sensitive T cell blasts , anti Fas mAb rapidly triggered downmodulation of a variety of antigens , including CD 2 , CD 4 , CD 8 , CD 7 , CD 44 , LFA1alpha , LFA1beta , and CD62L , but not CD 3 , CD 25 , or CD 26 . ^^^ Most of these antigens were not downmodulated by either CD 3 crosslinking ( except CD 3 ) or PMA treatment ( except CD 3 , CD 4 , and CD62L ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
These studies were conducted with highly purified ( FACS isolated ) subsets of CD 4 T cells identified by expression of both CD45RA and CD62L . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Notably , a similar pattern of increased CD3+ CD57+ , CD3+ HLA DR+ , CD3+ CD ( 16 + 56 ) + , CD 4 CD8+ , CD8+ CD57+ , CD8+ CD 28 , and CD8+ CD62L subsets was detected . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Analysis of NKR P 1 ( CD 161 ) , CD 4 , CD62L , CD 43 , CD11a , CD 18 and MHC class 2 expression identified at least two monocyte populations in all experimental groups . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Altered expression of CD 4 , CD 54 , CD62L , and CCR 5 in primary lymphocytes productively infected with the human immunodeficiency virus . ^^^ Expression of the CD 4 molecule was progressively lost and this was closely associated with loss of CD62L expression , a molecule involved in T cell homing into the lymph nodes . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Lymphocyte kinetics and precursor frequency dependent recovery of CD 4 ( + ) CD45RA ( + ) CD62L ( + ) naive T cells following triple drug therapy for HIV type 1 infection . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The double positive T cells could be differentiated from CD 4 single positive and CD 8 single positive T cells by their increased surface expression of LFA 1 and decreased CD62L expression . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Expression of CD 95 , CD45RA , CD45RO and CD62L on CD 4 and CD 8 T cells and of CD 34 on mononuclear cells was studied by multiparameter flow cytometry before and after 10 12 weeks of ART . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
These parameters were also compared with the proportion of CD 4 and CD 8 T cells that express CD62L and CD45RA , present on naive cells and down modulated in memory cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Coincident with these improvements , CD 38 and HLA DR coexpression on both CD 4 and CD 8 T cells decrease , and CD45RA and CD62L coexpression increase . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Nave CD 4 ( + ) T cells ( CD 44 ( lo ) , CD45RB+ , CD62L+ ) die as a consequence of Fas ligation in the presence of anti CD 3 antibody , whereas memory T cells ( CD 44 ( hi ) , CD45RB , CD62L ) , freshly isolated from the same starting population and subjected to the same stimulation conditions , are costimulated to proliferate by Fas ligation . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Memory and naive CD 4 ( + ) T cell subsets from 11 HIV 1 infected individuals were isolated ex vivo by a combination of magnetic bead depletion and fluorescence activated cell sorting techniques with stringent criteria of combined expression of CD45RA and CD62L to identify naive CD 4 ( + ) T cell subsets . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In the peripheral blood of adults aged 22 to 76 years , their frequency was highest in the CD 4 ( + ) CD45RA ( + ) CD62L ( + ) subpopulation of naive T cells . ^^^ TCR DCs were also observed in other subpopulations of peripheral blood T cells , including those with the CD 4 ( + ) CD45RO ( ) CD62L ( + ) and CD 4 ( + ) CD45RO ( + ) CD62L ( + ) phenotypes . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Flow cytometric analysis demonstrates that mPEG modification dramatically decreases antibody recognition of multiple molecules involved in essential cell : cell interactions , including both T cell molecules ( CD 2 , CD 3 , CD 4 , CD 8 , CD 28 , CD11a , CD62L ) and antigen presenting cell ( APC ) molecules ( CD 80 , CD 58 , CD62L ) likely preventing the initial adhesion and costimulatory events necessary for immune recognition and response . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In addition , nave ( CD45RA ( + ) and CD62L ( + ) ) CD 4 ( + ) and CD 8 ( + ) cells were the predominant phenotype of the marked CD 3 ( + ) T cells detected at early time points . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Similar abrogation of the Vbeta 4 ( + ) CD 8 ( + ) response is seen following antibody mediated depletion of the CD 4 ( + ) subset , through the numbers of CD 8 ( + ) CD62L ( lo ) cells are still significantly elevated . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Treatment with allergens , but not irritants , resulted in a selective increase in the percentages of CD 4 ( + ) and CD 8 ( + ) cells expressing the T cell activation / memory phenotype CD62L ( lo ) CD 44 ( hi ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
We identified functionally polarized subsets of CD 4 memory T cells on the basis of the expression of CD11a , CD45RA and CD62L . ^^^ Within the several phenotypically distinct subsets of CD 4 memory cells are two that , upon stimulation , produce primarily IL 4 ( MT ( 2 ) , CD45RA ( ) CD62L ( + ) CD11a ( dim ) ) or primarily IFN gamma ( MT ( 1 ) , CD45RA ( ) CD62L ( ) CD11a ( bright ) ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The CD 4 ( + ) CD 43 ( low ) subset exhibits a naive T cell phenotype , being CD62L ( high ) CD45RB ( high ) CD 44 ( low ) , whereas CD 4 ( + ) CD 43 ( high ) cells exhibit a memory phenotype , being CD62L ( low ) CD45RB ( low ) CD 44 ( high ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
However , small decreases in HLA DR ( + ) CD 38 ( + ) lymphocytes and of CD45RA ( + ) CD62L ( + ) were observed within both the CD 4 ( + ) and CD 8 ( + ) subsets . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In addition to being highly expressed ( approximately 1000 7000 STRL 33 ABS [ antibody binding sites ] ) on specific subsets of natural killer cells ( CD 3 ( ) / CD16 ( / low ) / CD56 ( + ) and CD 3 ( ) / CD16 ( low ) / CD56 ( ) ) and CD 19 ( + ) B lymphocytes ( approximately 300 5000 STRL 33 ABS ) , STRL 33 was expressed at levels sufficient to support virus infection on freshly isolated , truly naive CD 4 ( + ) / CD45RA ( + ) / CD62L ( + ) cells ( 6000 11 000 ABS ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
MS A showed a significant increase of CD 4 ( + ) CD45RA ( ) CCR 5 ( + ) cells ( Th 1 cells ) through the relapse and remission phases in comparison to HC , while MS W showed a significant increase of CD 4 ( + ) CD45RO ( + ) CD62L ( ) cells ( Th 1 cells ) only at the relapse phase . ^^^ HAM / TSP showed a significant increase of CCR 5 ( + ) and CD62L ( ) memory CD 4 ( + ) T cells as well as CD 30 ( + ) memory CD 4 ( + ) T cells ( Th 2 cells ) in comparison to HC . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
We determined that the rapid and sustained increase of both naive ( CD45RA ( + ) CD62L ( + ) ) and memory ( CD45R0 ( + ) and CD45RA ( + ) / CD62L ( ) ) CD 4 ( + ) and , to as lesser extent , CD 8 ( + ) T cells in peripheral blood was associated with a significant decrease of apoptotic CD 4 ( + ) and CD 8 ( + ) as well as CD 3 ( + ) CD 4 ( ) CD 8 ( ) T cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
These CD 4 ( + ) cells expressing CCR 8 were also CD 69 ( high ) CD62L ( low ) thymocytes , suggesting that they still needed to undergo some differentiation step before becoming functionally competent naive T cells ready to be exported from the thymus . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
CD 4 ( + ) Thy 1 ( ) thymocytes express high levels of CD 3 , intermediate to high levels of heat stable antigen ( HSA ) , and low levels of CD 25 , CD45RB , CD 69 , CD 44 and CD62L . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
CD 95 expression on CD45RA ( + ) CD45RO ( ) / CD62L ( + ) ( resting / naive ) and CD45RO ( + ) CD45RA ( ) ( primed / memory ) CD 4 ( + ) and CD 8 ( + ) T cells was assessed quantitatively by four color and three color flow cytometry . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
We present here an activation profile assay , using anti CD 3 and antigenic stimuli , that clearly distinguishes effector and memory CD 4 T cells and defines subsets of long lived memory CD 4 T cells based on CD 62 ligand ( CD62L ) expression . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In this study , we showed that anti GBM Ab induced GN was suppressed in several measures in the transgenic mice including the severity of glomerular changes , proteinuria , renal function , and CD 4 T cell infiltration into the glomeruli without down regulation of CD 62 ligand ( CD62L ) ( L selectin ) expression on CD 4 T cells . ^^^ Because CD62L on T cells appears to be inhibitory for the development of anti GBM Ab induced GN , persistent expression of CD62L on CD 4 T cells may explain , at least in part , the suppression of anti GBM Ab induced GN in the transgenic mice . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Autoreactive T cells specific to these autoantigens are present in most normal individuals but are kept under control by a number of peripheral tolerance mechanisms , among which CD 4 ( + ) CD 25 ( + ) CD62L ( + ) T cell mediated regulation probably plays a central role . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Our results suggest that CD62L is not required for activation of autoimmune CD 4 T cells but is important for the final destructive function of effector cells in the CNS and support a novel mechanism whereby CD62L expressed on effector cells is important in mediating myelin damage . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
To clarify the mechanism of immunodeficiency in those infected with HTLV 1 , this study analyzed the T cell subsets in HTLV 1 carriers and patients with HTLV 1 associated myelopathy / tropical spastic paraparesis and ATL using 3 color fluorescence with CD62L and CD45RA coexpression either with CD 4 ( + ) or CD 8 ( + ) T cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Expression of CD62L is not related to functional memory in CD 4 ( + ) T cells from cattle and CD62L ( + ) cells , particularly from the lymph nodes draining the skin and the lungs , stained with mAb to IFN gamma and IL 4 . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Here we show that this suppression occurs in total CD 4 T cells acutely infected with R 5 HIV , but not in purified CD62L ( ) memory CD 4 T cells . ^^^ Significantly , adding back naive or CD62L ( + ) memory CD 4 T cells inhibits the viral replication in the CD62L ( ) cells , with the naive cells capable of completely repressing the virus . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Using C3H / He mice infected with the Colombiana strain of T . cruzi , we found that the distribution of CD 4 ( + ) / CD8 ( ) and CD 4 ( ) / CD8 ( + ) T cells in the myocardium mirrors the frequency of cells expressing the CD62L ( Low ) LFA 1 ( High ) VLA 4 ( High ) activation phenotype among CD 4 ( + ) / CD8 ( ) and CD 4 ( ) / CD8 ( + ) peripheral blood T cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In addition to CD 2 , PSTPIP associated with CD 4 , CD 8 , CD 54 , and CD62L . ^^^ PSTPIP likely has additional broader effects through interactions with CD 4 , CD 8 , CD 54 , and CD62L , and this may influence T cell responses to antigen . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
After T cell transfer in lymphopenic recipients , the present results show that alloreactive T cells rapidly divided ; up regulated CD 69 , CD 25 , and CD 4 molecules ; and down regulated CD62L . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Most IL 4 producing clones were derived from CD 4 ( + ) cells of naive ( CD 44 ( low ) or CD62L ( high ) ) phenotype and the great majority coproduced IFN gamma and IL 3 . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Lymphocyte subset markers ( CD 4 , CD 8 , CD45RA , CD62L , CD 16 , CD 19 ) , activation markers ( HLA DR , CD 38 , CD 25 ) were performed by cytometry analysis . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
These cells , which express CD 4 , CD 25 , and CD62L , develop in the thymus and survive in a CD 28 dependent manner in the periphery to maintain the homeostatic equilibrium of immunity and tolerance . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : A new technique was developed to detect cytokine expression in phorbol 12 myristate 13 acetate / ionomycin activated CD62L and alpha4beta7 expressing CD 4 T cell subsets , using the protease inhibitor KD 9 73 4 . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
After infection , the majority of CD 4 ( + ) and CD 8 ( + ) splenocytes acquired an activated phenotype , as indicated by expression levels of CD 44 and CD62L . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In the present study , we demonstrate that CD62L ( + ) , CD 44 ( low ) and CD 4 ( + ) naive T cells from BALB / c mice are capable of producing significant amounts of IL 4 , while naive T cells from B10 . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
During the acute viremia phase , the high IL 12 dose monkeys showed an increase in CD 3 ( ) CD 8 alpha / alpha ( + ) and CD 3 ( + ) CD 8 alpha / alpha ( + ) cells and , unlike the control and low IL 12 dose animals , did not demonstrate an increase in CD 4 ( + ) CD45RA ( + ) CD62L ( + ) naive cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Most blood NK1 . 1 ( ) CD 4 ( + ) and CD 8 ( + ) T cells expressed the naive CD 44 ( int / lo ) CD62L ( hi ) CD45RB ( hi ) T cell phenotype typical of those in the peripheral lymphoid tissues . ^^^ In contrast , most marrow NK1 . 1 ( ) CD 4 ( + ) and CD 8 ( + ) T cells expressed an unusual CD 44 ( hi ) CD62L ( hi ) CD45RB ( hi ) phenotype . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The studied antigens were the following : CD 3 , CD 4 , CD 8 , CD 14 , CD 19 , CD 25 , CD 38 , CD 45 , CD45RO , CD 54 , CD 56 , CD62L , CD 71 and HLA DR . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Resting CD 4 ( + ) T cells with CD 38 ( + ) CD62L ( + ) produce interleukin 4 which contributes to enhanced replication of T tropic human immunodeficiency virus type 1 . ^^^ We previously reported a higher replication rate of T tropic HIV 1 in the CD 4 ( + ) CD 38 ( + ) CD62L ( + ) than CD 38 ( ) subset under conditions of mitogen stimulation after infection . ^^^ Thus , the CD 4 ( + ) CD 38 ( + ) CD62L ( + ) subset comprises a specific cell population secreting endogenous Th 2 cytokine that contributes to the efficient production of T tropic HIV 1 through upregulation at a certain stage of the viral life cycle , probably after the adsorption step . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Expansion of CD 44 ( hi ) CD62L ( low ) CD 4 ( + ) T cells in the lung occurred following aerosol and intravenous BCG immunizations , and the lymphocyte recruitment was proportional to the pulmonary bacterial load . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The TIL within metastatic carcinoma , but not within primary carcinoma , revealed the increased proportions of CD 3 ( + ) T cells bearing CD 8 ( + ) CD11b ( ) , CD 8 ( + ) CD11b ( + ) , and CD 4 ( + ) CD62L ( ) , CD 4 ( + ) CD62L ( + ) surface phenotype in patients . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Adoptive transfer experiments with CD62L ( / ) CD 4 ( + ) T cells prepared from BDC2 . 5 TCR transgenic mice revealed no apparent defects in migration to pancreatic lymph nodes , proliferation in response to beta cell Ag , or induction of diabetes in NOD . scid recipients . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
CD 4 ( + ) T cells producing IFN gamma are CD62L ( ) , and CD 4 ( + ) T cells producing IL 10 are CD62L ( + ) , indicating that these cells have different tissue homing capacities . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Results : In CIU patients compared to controls , it was found that ( 1 ) TNF alpha , IL 10 , MIP 1alpha and RANTES production was augmented and IL 2 and INF gamma reduced , and ( 2 ) CD 44 , CD11a and CD62L expression on CD 4 and CD 8 cells was augmented . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
During allograft rejection or after infusion of interferon gamma they up regulate class 2 MHC molecules , CD 161 ( NKR P1A ) , CD62L and CD 8 , while CD 4 and CD 43 are down modulated . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Cardiac reactors showed a significant decrease of surface density of CD62L on mixed lymphocytes ( p < . 001 ) as well as on CD 4 ( p < . 01 ) and CD 8 T cells ( p < . 001 ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The increase in Th 2 differentiation is correlated to an increase of IL 4 secretion by CD 4 ( + ) DX 5 ( + ) TCR alpha beta ( + ) CD62L ( low ) T cells but not to increased expansion of differentiating Th 2 cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Here , we report that the 5 alpha 24 NKT cells can be subdivided into CD 4 ( + ) or CD 4 ( ) subsets that differ in their expression of the homing receptors CD62L and CD11a . ^^^ Thus , HIV infection causes a selective loss of CD 4 ( + ) lymph node homing ( CD62L ( + ) ) NKT cells , with consequent skewing of the NKT cell compartment to a predominantly CD 4 ( ) CD62L ( ) phenotype . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In addition , anti CD45RB treatment led to reduced expression of LFA 1 and CD 62 ligand ( CD62L ) on CD 4 T cells , independent of antigenic challenge . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Furthermore , CD62L expression is necessary for this disease delaying effect of CD 4 ( + ) CD 25 ( + ) cells in vivo , but not for their suppressor function in vitro . ^^^ We demonstrate that the CD 4 ( + ) CD 25 ( + ) CD62L ( + ) splenocytes express CCR 7 at high levels and migrate toward secondary lymphoid tissue chemokine and ELC ( macrophage inflammatory protein 3beta ) , lymphoid chemokines , whereas CD 4 ( + ) CD 25 ( + ) CD62L ( ) splenocytes preferentially express CCR 2 , CCR 4 , and CXCR 3 and migrate toward the corresponding inflammatory chemokines . ^^^ These data demonstrate that CD 4 ( + ) CD 25 ( + ) CD62L ( + ) , but not CD 4 ( + ) CD 25 ( + ) CD62L ( ) , splenocytes delay diabetes transfer , and that CD 4 ( + ) CD 25 ( + ) suppressor T cells are comprised of at least two subpopulations that behave differently in cotransfer in vivo and express distinct chemokine receptor and chemotactic response profiles despite demonstrating equivalent suppressor functions in vitro . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
CD 4 ( + ) IFN gamma ( + ) T cells had a CD45RA ( ) CD62L ( ) ( effector memory ) phenotype and most coexpressed interleukin 2 . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Compared with pre G CD 4 ( + ) T cells , alloantigen activated post G CD 4 ( + ) T cells preferentially expressed markers associated with memory T cells , in conjunction with reduced levels of CD 28 and CD62L . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Moreover , the Rec group produced similar percentages and absolute counts of naive ( CD45RA ( + ) CD62L ( + ) ) CD 4 ( + ) and CD 8 ( + ) T cells , and TRECs similar to those of the LTA group . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Stimulation with PPD or PWM increased CD 25 and CD 44 mean fluorescence intensity ( MFI ) and decreased CD62L MFI on CD 4 ( + ) cells from infected animals . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
We show here that IL 15 preferentially enhances the activation and effector function of human effector memory CD45RA ( ) CD62L ( ) and CD45RA ( + ) CD62L ( ) CD 4 ( + ) and CD 8 ( + ) T cells in both healthy and HIV infected individuals . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Naive ( CD45RA ( high ) , CD62L ( high ) ) CD 4 ( + ) T cells derived from cord blood cells , in contrast to other primary cells and all cell lines examined , bound no detectable HTLV 1 SU . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
We also determined the phenotype of the cultured T cells using anti CD 3 , CD 4 , and CD62L specific monoclonal antibodies . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Flow cytometry was used to detect the count of CD 4 ( + ) T lymphocytes , CD 8 ( + ) T lymphocytes , and its different subsets including the naive cell subset ( CD 4 ( + ) CD45RA ( + ) CD62L ( + ) ) , activated cell subsets ( CD 4 ( + ) HLA DR ( + ) , CD 8 ( + ) HLA DR ( + ) , CD 8 ( + ) CD 38 ( + ) ) , functional cell subsets ( CD 4 ( + ) CD 28 ( + ) ) , and apoptotic cell subsets ( CD 4 ( + ) CD 95 ( + ) , CD 8 ( + ) CD 95 ( + ) ) . ^^^ The percentage of CD 4 ( + ) CD45RA ( + ) CD62L ( + ) were 43 . 0 % + / 11 . 4 % in the control group , not significantly different from that in HIV infected person group ( 44 . 2 % + / 12 . 8 % ) , but significantly higher than that in AIDS patient group ( 24 . 8 % + / 15 . 5 % , P < 0 . 05 ) . ^^^ The CD 4 ( + ) CD45RA ( + ) CD62L ( + ) cell count was ( 368 + / 162 ) 10 10 ( 6 ) / L in the control group , significantly higher than those in HIV infected person group [ ( 185 + / 134 ) 10 10 ( 6 ) / L ] and in AIDS patient group [ ( 18 + / 20 ) 10 10 ( 6 ) / L , both P < 0 . 01 ] with a significant difference between the HIV infected person group and AIDS patient group ( P < 0 . 01 ) . ^^^ The plasma HIV loading was 3 . 74 + / 0 . 78 lg copies / ml in the HIV infected person group and was 4 . 94 + / 0 . 68 lg copies / ml in AIDS patient group ( P < 0 . 05 ) , and the count of CD 4 ( + ) cells and CD 4 ( + ) CD45RA ( + ) CD62L ( + ) cells were obviously negatively correlated with the plasma HIV loading ( r = 0 . 796 , r = 0 . 750 , P < 0 . 01 ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The enhanced expression of memory markers ( CD 44 and CD62L ( low ) ) on CD 4 ( + ) T cells of the d3tx mice was unaffected by CD40L mAb treatment . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
CD 4 ( ) central memory NKT cells , however , were atypical in that they largely lacked CD62L expression . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
CD45RB ( low ) , CD 69 ( high ) , CD 44 ( high ) and CD62L ( low ) , and belonged to a CD 4 ( + ) CD 8 ( + ) population expressing c kit , IL 7R and pTalpha characteristic of immature developing lymphocytes . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Adoptive transfer of CD 4 ( + ) CD62L ( low ) CD 44 ( high ) activated / effector T cells 24 h prior to ACI into RAG 1 ( / ) mice resulted in a significantly enhanced acute ACI that was comparable to ACI in the C57BL / 6 animals . ^^^ Adoptive transfer of CD 4 ( + ) CD62L ( high ) CD 44 ( low ) naive / non activated T cells did not increase ACI in the brains of RAG 1 ( / ) mice . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
We show that this mutation drives the generation of a pool of memory CD 44 ( high ) CD62L ( neg ) CD45RB ( neg ) CD 4 TCR transgenic T cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
METHODS : CD 4 cell subsets were evaluated by flow cytometry using anti CD45RO / RA , CD62L , Ki 67 and CD 95 monoclonal antibodies . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The generality of the latter finding was demonstrated by the fact that CCL20 / CCR6 interactions increase the basal proliferation rate of CD62L ( lo ) CD 4 T cells irrespective of their thymic ( in non OM transgenic mice ) or extrathymic ( in LckOM mice ) origin . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
A detailed analysis of the CD 4 ( + ) T cells within the malignant effusion revealed that these cells uniformly expressed a CCR 7 ( + ) CD62L ( + ) `` non effector ' ' phenotype . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Monoclonal CD 4 ( + ) T LGLshowed expression of TCRalphabeta , variable levels of CD 8 ( CD 8 ( / +dim ) ) and a homogeneous typical cytotoxic ( granzyme B ( + ) , CD 56 ( + ) , CD 57 ( + ) , CD11b ( + / ) ) and activated / memory T cell ( CD 2 ( +bright ) , CD 7 ( / +dim ) , CD11a ( +bright ) , CD 28 ( ) , CD62L ( ) HLA DR ( + ) ) immunophenotype . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Using flow cytometric staining of T cells for visualisation expression of CCR 7 in association with CD62L and CD 44 , a major population of CD 4 or CD 8 T cells expressing CCR 7 were found to be CD62Lhigh CD44low , which would suggest a nave cell phenotype . ^^^ Analysis of effector T cells , induced by immunization in vivo , showed that a proportion of activated nave CD 4 T cells down regulated CCR 7 only after multiple cell divisions , and this coincided with the down regulation of CD62L and production of IL 4 and IFN gamma . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In addition , we examined the heterogeneity of CD 4 T cell responses in vivo through the analysis of the expression , by activated T cells , of different selectins , including P selectin ligand and CD62L known to define separable effector populations . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Both central ( CD62L+ ) and effector ( CD62L ) memory phenotype CD 4 cells required IL 7 for survival and , in vivo , memory cells were comparable to naive CD 4 cells in this regard . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
We investigated CD1b , CD 3 , CD 4 , CD 8 , CD 14 , CD45RO , CD62L and CD 161 expression in peripheral blood mononuclear cells ( PBMC ) by flow cytometry , and serum levels of interleukin ( IL 2 ) , IL 4 , granulocyte macrophage colony stimulating factor ( GM CSF ) , IL 13 and interferon ( IFN ) gamma by enzyme linked immunosorbent assay ( ELISA ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Interestingly , the percentage of CD 4 ( + ) T cells expressing CD62L was selectively reduced in BPD infants . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Thymus and lymph nodes of vitamin D deficient mice contained less CD 4 ( + ) CD62L ( + ) cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
We hypothesized that cGVHD might be associated with a preponderance of CD 4 ( + ) effector memory cells ( CCR 7 ( ) / CD62L ( low ) , CD 4 ( EM ) ) . ^^^ We analyzed CCR 7 and CD62L expression on CD 4 ( + ) T cells from stem cell transplantation patients , who did or did not develop cGVHD , and healthy donors . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In particular , CD 4 ( + ) CD62L ( + ) T cells declined after treatment . ^^^ FTY predominantly reduces CD 4 ( + ) CD62L ( + ) cells in the peripheral blood suggesting increased migration into lymph nodes . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In the absence of CD 4 T cell help , a distinct subset of memory CD 8 T cells develops that remains CD62L ( low ) up to 1 year after infection and exhibits a CD 44 ( int ) CD 122 ( low ) phenotype . ^^^ Moreover , these data imply that the development of CD62L ( high ) central memory CD 8 T cells is arrested in the absence of CD 4 T cell help . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In the present study , we used double labeling with CD45RO and CD62L for reliable identification of nave and memory cell subsets in both CD 4 and CD 8 T cell populations among 533 Hiroshima A bomb survivors . ^^^ Furthermore , the percentages of CD45RO+ / CD62L+ and CD45RO+ / CD62L memory T cells were found to increase significantly with increasing radiation dose in the CD 8 T cell population but not in the CD 4 T cell population . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
APRIL ( / ) mice have normal T and B lymphocyte development , normal T and B cell proliferation in vitro , but increased numbers of CD 44 ( hi ) CD62L ( lo ) CD 4 ( + ) effector / memory T cells and increased IgG responses to T dependent antigens . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Chronic colitis was induced by transfer of CD 4 ( + ) CD62L ( + ) T lymphocytes from BALB / c mice in SCID mice . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Measures of activation included changes in CD 4 , CD 25 , CD 44 , CD45RB , CD62L , CD 69 , caspase 3 activation , CFSE dilution , size , number of cells recovered , and cytokine production . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
These responses are stably detectable ex vivo at low frequencies ( range , 0 . 00012 to 0 . 0061 % of CD 4 T cells ) and display a distinct `` central memory ' ' CD62L ( + ) phenotype . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
CD 4 ( + ) CD45RA ( hi+ ) CD62L ( + ) , CD 4 ( + ) CD45RA ( + ) and CD 4 ( + ) CD 38 ( + ) percentages , and the CD 8 ( + ) CD45RA ( hi+ ) CD62L ( + ) counts reached similar values to the control group . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The relevance of this finding was further evaluated in an animal model of CD induced by adoptive transfer of CD 4 ( + ) CD62L ( + ) T cells in RAG deficient mice . ^^^ Interestingly , adoptive transfer of c Maf transgenic CD 4 ( + ) CD62L ( + ) T cells in RAG 1 deficient mice resulted in an IL 4 dependent inability to induce colitis and suppressed colitis activity induced by wild type CD 4 ( + ) CD62L ( + ) T cells . ^^^ In contrast , transfer of CD 4 ( + ) CD62L ( ) T cells from c Maf transgenic , but not wild type mice induced colitis and augmented colitis induced by CD 4 ( + ) CD62L ( + ) T cells from wild type mice in an IL 4 independent pathway , as determined by macroscopic , histologic , and endoscopic criteria . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Effector CD 4 ( + ) T cells are known to express CD 44 ( hi ) CD62L ( lo ) surface phenotype . ^^^ In this paper we demonstrate that a population of CD 44 ( hi ) CD62L ( lo ) CD 4 ( + ) effectors generated in response to Mycobacterium bovis BCG or M . tuberculosis infection in C57BL / 6 mice is heterogeneous and consists of CD 27 ( hi ) and CD 27 ( lo ) T cell subsets . ^^^ In addition , CD 27 ( lo ) CD 4 ( + ) T cells uniformly express CD 44 ( hi ) CD62L ( lo ) phenotype . ^^^ We propose that CD 27 ( lo ) CD 44 ( hi ) CD62L ( lo ) CD 4 ( + ) T cells represent highly differentiated effector cells with a high capacity for IFN gamma secretion and antimycobacterial protection at the site of infection . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Treatment of NOD mice with a mitogenic anti CD 3 depletes CD 4 ( + ) CD 25 ( ) CD62L ( + ) but not CD 4 ( + ) CD 25 ( + ) CD62L ( + ) T cells , thereby resulting in an increase of the latter subset in the spleen . ^^^ These results demonstrate that the capacity of anti CD 3 to protect NOD mice from T1D correlates with its ability to perturb T cell homeostasis by inducing CD 8 ( + ) T cell AICD and increasing the number of CD 4 ( + ) CD 25 ( + ) CD62L ( + ) T cells in the periphery . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
CD 4 ( + ) CD 25 ( + ) cells display CD45RO ( high ) , CD45RA ( low ) , CD 28 ( high ) , CD62L ( high ) , and CD 95 ( high ) phenotype . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Moreover , increased numbers of activated CD 4 ( + ) CD 44 ( high ) CD62L ( low ) cells in the lungs and draining lymph nodes suggested improved Ag presentation by the APCs . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
A higher proviral DNA level was associated with increases in CD 4 ( + ) CD45RA ( ) CD 28 ( ) effector cells and reductions in naive CD 4 ( + ) CD45RA ( + ) CD62L ( + ) and CD 8 ( + ) CD45RA ( + ) CD62L ( + ) cells ( P < . 05 ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
At 18 26 months EBNA 1 transgenic mice did not differ from littermate control in ultimate body weight , in spleen size or weight , in lymph node , kidney , liver , or spleen histology , in splenocyte fractions positive for cluster of differentiation ( CD ) 3epsilon , CD 4 , CD 8 , CD62L , B 220 , CD 5 , IgM , IgD , MHC class 2 , CD11b , or CD 25 , or in serum IgM , IgG , or total Ig levels . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Further studies showed that noncultured zetaKO mice CD 4 ( + ) T cells and thymocytes bore a unique memory cell like CD 44 ( high ) , CD62L ( low / neg ) phenotype . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
We established the age dependent incidence , time course , and duration of thymic enlargement in adults and demonstrated that these changes were correlated with peripheral recovery of naive CD45RA ( + ) CD62L ( + ) and signal joint TCR rearrangement excision circle bearing CD 4 ( + ) populations with broad TCR diversity . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Regulatory T cells ( Tregs ) are CD 4 ( + ) CD 25 ( bright ) CD62L ( high ) cells that actively down regulate immune responses . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The suppressor function of CD 4 ( + ) CD 25 ( + ) CD62L ( hi ) T cells , mediated by TGFbeta , declined in an age dependent manner . ^^^ This loss of function coincided with a temporal decrease in the percentage of FoxP 3 and TGFbeta 1 coexpressing T cells within pancreatic lymph node and islet infiltrating CD 4 ( + ) CD 25 ( + ) CD62L ( hi ) T cells , and was detected in female NOD mice but not in NOD male mice , or NOR or C57BL / 6 female mice . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Polarization of Th1 / Th2 in human CD 4 T cells separated by CD62L : analysis by transcription factors . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
RESULTS : CD 4 ( + ) CD62L ( + ) T cells from CpG ODN treated donors did not induce significant intestinal inflammation in SCID recipients , in contrast with control cells . ^^^ Additionally , cotransfer of these cells with CD 4 ( + ) CD62L ( + ) cells from normal mice protected recipient animals from colitis , indicating regulatory activity . ^^^ Also , CD 4 ( + ) CD62L ( + ) cells from toll like receptor 9 deficient animals induced a significantly more severe colitis in SCID recipients than cells from wild type littermate controls , suggesting a similar protective role of `` endogenous ' ' bacterial DNA leading to a less `` aggressive ' ' phenotype of these cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
An expansion of CD 4 ( + ) CD 25 ( + ) CD62L ( high ) T cells was observed specifically within the LN of tolerant animals , but not in other anatomic sites or under nontolerizing conditions . ^^^ However , administration of FTY 720 , a sphingosine 1 phosphate receptor modulator that induces CD62L independent T cell accumulation in the LNs , restored CD 4 ( + ) CD 25 ( + ) Treg in the LNs along with graft survival . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Specifically , pre transplant memory CD 4 + CD45RA CD62L T cell levels correlated with PFS ( P = 0 . 01 ) . ^^^ The prognostic effects of pre transplant CD 4 and CD 4 + CD45RA CD62L T cells were independent of tumor diagnosis , tumor stage , tumor sensitivity , and , for breast cancer patients , Her 2 / neu status . ^^^ Our results suggest that pre transplant CD 4 T cell status , specifically CD 4 + CD45RA CD62L memory T cells , correlates with the outcome of autologous HPCT recipients . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
METHODS : Clinical course and histology were evaluated after transfer of CD 4 ( + ) CD62L ( + ) lymphocytes from germ free and conventionally housed donor mice into SCID recipients . ^^^ Cotransfer of CD 4 ( + ) CD62L ( + ) cells with CD 4 ( + ) CD62L ( ) lymphocytes from both groups of mice was initiated . ^^^ Additionally , CD 4 ( + ) CD62L ( ) cells from germ free mice were not able to abrogate colitis induced by cotransfer with CD 4 ( + ) CD62L ( + ) lymphocytes whereas CD 4 ( + ) CD62L ( ) T cells from normal mice ameliorated disease . ^^^ The higher percentage of CD 4 ( + ) GITR ( + ) expressing lymphocytes and the production of interleukin 10 after priming by dendritic cells suggests the presence of T ( reg ) cells within the CD 4 ( + ) CD62L ( + ) lymphocyte subset derived from conventional housed mice and assumes a lack of T ( reg ) cells within germ free mice . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The most significant changes during the 48 week study period were seen for CD 8 ( + ) , CD 8 ( + ) CD62L ( + ) CD45RA ( + ) , CD 8 ( + ) CD 38 ( + ) HLA DR ( + ) , and CD 4 ( + ) T cell percentages ( P < . 0001 for all parameters ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
LACK specific CD 44 ( high ) CD62L ( low ) CD 4 T cells accumulated in the draining lymph nodes and had characteristics of effector cells , secreting IL 2 and IFN gamma upon Ag restimulation . ^^^ Indeed , LACK specific CD 4 T cells with central memory features ( IL 2 ( + ) IFN gamma ( ) CD 44 ( high ) CD62L ( high ) cells ) accumulated in all peripheral lymph nodes of mice immunized with LACK pulsed dendritic cells and after tumor resection . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
We have also found that Sle1c was associated with the production of histone specific autoreactive CD 4 ( + ) T cells , which correlated with higher activation and proliferative responses , and a reduction in the CD 4 ( + ) CD 25 ( + ) CD62L ( + ) forkhead / winged helix transcription factor gene ( Foxp 3 ( + ) ) compartment . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Relative to the pokeweed mitogen induced responses of CD 4 ( + ) cells from steers ( 5 to 6 mo of age ) , CD 4 ( + ) cells from 1 wk old calves showed decreased proliferative activity , delayed increase in CD 25 expression , and no demonstrable increase in CD 44 expression or decrease in CD62L expression . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The expanded Valpha14i NKT cells retained the memory / activated ( CD 44 ( + ) CD 69 ( + ) CD62L ( ) ) and CD 4 ( + ) or CD 4 ( ) 8 ( ) double negative phenotypes but modulated or lost the classical NKT cell marker , NK1 . 1 . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In contrast , SEA / CFA immunized IL 12p35 ( / ) mice , able to make IL 23 but not IL 12 , developed severe lesions that correlated with high levels of IL 17 , low IFN gamma , and an expansion of activated CD 4 T cells with a CD 44 ( high ) / CD62L ( low ) memory phenotype . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The regulatory activity generated in tumor draining LNs exclusively belonged to the CD 4 ( + ) T cell subpopulation that expresses both CD 25 and a high level of CD62L . ^^^ Forkhead / winged helix transcription factor gene expression was detected only in the CD62L ( high ) CD 4 ( + ) CD 25 ( + ) T cells . ^^^ CD62L ( high ) CD 4 ( + ) CD 25 ( + ) Treg and CD62L ( low ) CD 4 ( + ) CD 25 ( + ) T cells , which possess effector T cell functions , had comparable expression of LFA 1 , VLA 4 , CTLA 4 , lymphocyte activation gene 3 , and glucocorticoid induced TNFR . ^^^ Thus , only CD62L expression could distinguish regulatory CD 4 ( + ) CD 25 ( + ) cells from effector CD 4 ( + ) CD 25 ( + ) cells in draining LNs as a surface marker . ^^^ CD62L ( high ) CD 4 ( + ) CD 25 ( + ) Treg contained a subpopulation that expressed CD 86 . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Furthermore , the cells expressing medium to low levels of CD 25 not only do not exhibit suppressive activity directly ex vivo , but also actually contain a significant proportion of CD62L CD 4 T cells which are believed to be in vivo activated T cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Preferential expansion of CD 8 ( + ) and partial inhibition in the increase of CD 4 ( + ) CD 69 ( + ) and CD 8 ( + ) CD 69 ( + ) in CD 4 ( + ) CD 44 ( + ) and CD 8 ( + ) CD 44 ( + ) and in the decrease of CD 8 ( + ) CD62L in Trypanosoma cruzi infected mice were also observed . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Here , we investigated the role of CD62L expression in the generation , function , distribution and migration of heterogeneous memory CD 4 T cells specific for influenza hemagglutinin ( HA ) . ^^^ Our results reveal novel phenotypic heterogeneity of memory CD 4 T cells co segregating with CD62L expression and tissue specific tropism of non lymphoid memory CD 4 T cells . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Few CD 4 ( + ) and CD 8 ( + ) T cells expressed an activated phenotype ( CD 44 ( hi , ) CD 25 ( + ) , CD 69 ( + ) , CD62L ( lo ) , CD45RB ( lo ) ) at the sites of clonal expansion ( lymph nodes , spleen , and blood ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Within the ' primed ' CD 4 ( + ) , 45R0 ( + ) T cells , the ' central memory ' cells expressing the CD62L and CD 27 markers were the slowest to recover . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
IL 15 upregulated CD45RO and CD 25 whereas it down regulated CD62L expression of CD3 / CD28 stimulated CD 4 ( + ) T cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The SARS CoV S specific CD 4 ( + ) and CD 8 ( + ) T cells were CD62L ( ) , a marker for memory cells , and 30 to 50 % of the cells expressed IL 7Ralpha ( CD 127 ) , a marker for the capacity of effector cells to develop into memory cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The N specific IFN gamma ( + ) CD 4 ( + ) T cells were mainly composed of CD45RA ( ) CCR 7 ( + ) CD62L ( ) cells , whereas IFN gamma ( + ) CD 8 ( + ) memory T cells were mostly contained within CD45RA ( + ) CCR 7 ( ) CD62L ( ) cell population . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Interestingly , most of SARS CoV S specific memory CD 4 ( + ) T cells were central memory cells expressing CD45RO ( + ) CCR 7 ( + ) CD62L ( ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The effector memory subset within the CD 4 T cell population , defined as CD45RO , CD62L and CCR 7 , which constitutes less than 10 % of total CD 4 T cells , does respond to IP 10 but requires enrichment to be observed in this model . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Purified CD 4 ( + ) CD 25 ( + ) CD62L ( high ) B / W T ( regs ) were expanded ex vivo 80 fold , resulting in cells with a stable suppressor phenotype . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
TRL 01 had the same immunophenotype as the original leukemia cells : positive for CD 13 , CD 33 , CD11a , CD 18 , CD 29 , CD49d , CD49e , CD 54 , CD62L , and CD 117 , and negative for CD 3 , CD 4 , CD 8 , CD 19 , CD 34 , CD41a , CD41b , CD 135 , and myeloperoxidase . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Thus , the proportions of lymphocytes with the following phenotypes : CD 3 ( + ) , CD 2 ( + ) , CD 7 ( + ) , CD 4 ( + ) , CD62L ( + ) , CD 4 ( + ) CD62L ( + ) and CD 4 ( + ) CD 69 ( ) were significantly reduced in the study group compared with the control group , but significantly higher proportions were seen of lymphocytes expressing CD8alpha ( + ) CD8beta ( ) and TCRgammadelta ( + ) CD8alpha ( + ) CD8beta ( ) . ^^^ The absolute number and proportion of CD 4 ( + ) CD 25 ( + ) cells were reduced but the proportions of the subgroup of naive regulatory T cells ( CD 4 ( + ) CD 25 ( + ) CD62L ( + ) ) and non activated regulatory T cells ( CD 4 ( + ) CD 25 ( + ) CD 69 ( ) ) were not reduced in the thymectomized children . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In addition , PT promoted the generation of CD 4 ( + ) CD62L ( low ) effector T cells in vivo . ^^^ Upon adoptive transfer , these cells were more potent than CD 4 ( + ) CD62L ( high ) cells in inducing autoimmunity in recipient mice . ^^^ Collectively , these data demonstrate the induction of autoimmunity by specific in vivo expansion of CD 4 ( + ) CD62L ( low ) cells and indicate that CD 4 ( + ) CD62L ( low ) effector T cells and CD11c ( + ) CD 4 ( + ) dendritic cells may be attractive targets for immune interventions to treat autoimmune diseases . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Circulating CD 4 lymphocyte subset ( CD45RA ; CD45RO ; CD 29 ; Leu 8 ) levels were determined in nine patients with 10 linked agammaglobulinaemia ( XLA ) , nine patients with common variable immunodeficiency ( CVI ) and in 18 age and sex matched controls . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Surface marker analysis revealed that HSM 1 expressed CD 4 , CD 13 , CD11a , CD11b , Leu 8 , CD49b , CD49d , CD49e , CD 29 and HLA DR . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Throughout the duration of the study , the percentage of lymphoid cells that expressed CD 3 , CD 4 , CD 8 , CD 19 , Leu 8 , and other markers remained relatively constant although the absolute numbers of these cells varied . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In addition , the proportion of CD 9 + 11b + suppressor T cells decreased in the RNL of the short term PSK group , whereas the proportion of CD 4 + Leu 8 helper T cells in the RNL increased in the long term PSK group . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Both CD 4 and CD 8 T cells are subdivided into two phenotypically distinct sublineages via another two T cell markers , Leu 8 and CD11b antigens . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Isoprinosine significantly enhanced the lymphoproliferative response after stimulation with phytohaemagglutinin ( PHA ) and purified derivative of tuberculin ( PPD ) , while isoprinosine had no effect on the following immune parameters : the expression of surface markers on blood mononuclear cells including CD 2 , CD 3 , CD 4 , CD 8 , CD 14 , CD 19 , CD 20 , CD 25 , leu 8 , and HLA DR . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Cell surface markers CD 4 , CD 8 , Leu 8 and Leu 15 ( CD 11 ) were used to separate human lymphoid cell subsets with monoclonal antibody coated immunomagnetic beads . ^^^ By contrast , depending on donor and lymphoid tissue examined ( tonsils or peripheral blood mononuclear cells ) , CD 4 , CD 8 , Leu 8 , and Leu 15 cell subsets are also able to express IL 2 or IFN gamma genes to high levels . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Pituitary adrenal immune system in normal subjects and in patients with anorexia nervosa : the number of circulating helper T lymphocytes ( CD 4 ) expressing the homing receptor Leu 8 is regulated in part by pituitary adrenal products . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The proportion of CD 4 cells bearing the CD45RA and Leu 8 markers is consistently lower in adults than in children . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
That LC acts on CD 8 ( ) Leu 8 ( + ) cells was confirmed by the finding that LC inhibited ISC generation of non T plus CD 4 ( + ) Leu 8 ( + ) , but not of non T plus CD 8 ( ) Leu 8 ( ) cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In the present study a comparative immunohistochemical study was performed on skin biopsies from of patients with Jessner ' s lymphocytic infiltration of the skin ( LIS ) , polymorphous light eruption ( PLE ) , discoid lupus erythematosus ( DLE ) and subacute cutaneous lupus erythematosus ( SCLE ) using a large panel of monoclonal antibodies against T cell differentiation antigens ( CD 3 , CD 4 , CD 8 ) , immunoregulatory T cell subsets ( CD 7 , 4B4 , 2H4 , Leu 8 ) , B cells ( CD 22 ) , activated cells CD 25 , OKT 9 , HLA DR ) , Langerhans cells ( CD 1 ) and macrophages ( Leu M 5 ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
These subsets included B , T , CD 4 , and CD 8 cells and subpopulations of CD 4 and CD 8 cells defined by the coexpression of markers that appear ( CD 25 , HLA DR , CD 38 ) or disappear ( Leu 8 , CD45RA ) after activation . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Dual label flow cytometric analysis of cerebrospinal fluid ( CSF ) and blood lymphocytes with combinations of monoclonal antibodies such as CD 4 plus CD45R or Leu 8 , and CD 8 plus CD11b was performed in 37 patients with noninflammatory neurological diseases ( NINDs ) to clarify the differences in cellular immunoregulatory mechanisms present in the central nervous system ( CNS ) and in the systemic circulation . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Of seventy mAb recognizing human T cell antigens screened on the CD4+ and CD 4 variants of the two hybrids , only mAb recognizing CD 4 and Leu 8 reacted with the CD4+ cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Dual color analyses showed that CD 4 cell loss in the HIV group did not occur preferentially within CD 4 subsets defined by Leu 8 or CD45R expression . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The CD 4 Leu 8 T helper cell in colonic mucosa : a quantitative and functional analysis . ^^^ CD 4 T cells in the colonic lamina propria are primarily B cell helper as identified by their surface phenotype CD 4 Leu 8 ( CD 4 Leu 8+ : CD 4 Leu 8 ratio = 1 : 3 . 5 ) . ^^^ This is in contrast to autologous peripheral blood where CD 4 Leu 8+ cells predominate ( CD 4 Leu 8+ : CD 4 Leu 8 ratio = 2 . 4 : 1 ) . ^^^ Functionally CD 4 Leu 8 T cells isolated from the colon are able to provide autologous peripheral blood B cell help comparable to that of peripheral blood CD 4 Leu 8 T cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
There appeared to be no clear correlation , however , with subsets of CD 4 T cells defined by the 2H4 and Leu 8 MAbs . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The antibodies against human T lymphocyte were anti CD 3 , CD 4 , CD 8 , CD 4 10 Leu 8 , CD 4 10 4B4 and CD 8 10 CD 11 . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In order to characterize the effects of HIV ( human T lymphotropic virus type III / lymphadenopathy associated virus ) on the immune system , Leu 8 and Leu8+ subsets of CD 4 and CD 8 cells were studied in seropositive homosexually active men without acquired immune deficiency syndrome ( AIDS ) . ^^^ The decrease in CD 4 levels , observed in HIV seropositive men who were asymptomatic , as well as in those who had persistent generalized lymphadenopathy or constitutional symptoms of HIV infection , occurred proportionally in both the Leu 8 and the Leu8+ CD 4 subsets . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
CD 4 positive Leu 8 negative helper inducer T cells predominate in the human intestinal lamina propria . ^^^ The regulatory function of peripheral blood CD 4 T cells correlates with the presence or absence of the membrane glycoprotein recognized by anti Leu 8 antibody ; CD 4 , Leu 8 T cells help Ig synthesis and CD 4 , Leu 8+ T cells suppress Ig synthesis . ^^^ In contrast to CD 4 T cells from the peripheral blood and organized gut associated lymphoid tissues , intestinal lamina propria CD 4 T cells were found to have diminished expression of the Leu 8 Ag . ^^^ Therefore , studies were performed to determine whether the decreased expression of the Leu 8 Ag on lamina propria CD 4 T cells correlates with a difference in the ability of peripheral blood and lamina propria CD 4 T cells to regulate PWM stimulated Ig synthesis . ^^^ When CD 4 T cells were incubated with anti Leu 8 antibody , the suppressor function of peripheral blood CD 4 T cells was increased , but lamina propria CD 4 T cells did not suppress Ig synthesis . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The cell was negative for antibodies to Leu 2 ( CD 8 ) , Leu 3 ( CD 4 ) , Leu 4 ( CD 3 ) , Leu 5 ( CD 2 ) , Leu 7 , Leu 8 , Leu 11 ( CD 16 ) , Leu M 1 ( CD 15 ) , Leu M 3 , and CALLA ( CD 10 ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Alterations observed in asymptomatic seropositive donors ( ASP ) included : 1 ) decreased mean levels of Leu 8+ CD 4 cells , although the proportion of Leu 8+ cells within the CD 4 population was unchanged ; 2 ) a selective increase in Leu 8 CD 8 and Leu 18 CD 8 cell levels ; and 3 ) increased levels of both CD 8 subsets defined by Leu 7 , Leu 17 , or HLA DR expression . ^^^ Alterations observed in symptomatic seropositive donors ( SSP ) were : 1 ) a further decrease in Leu 8+ CD 4 cell levels , with a decrease in the proportion of Leu 8+ CD 4 cells ; 2 ) decreased levels of both Leu 18 and Leu 18+ CD 4 subsets ; 3 ) selective increases in Leu 8 and Leu 18 CD 8 cell levels ; and 4 ) increases in Leu 7+ CD 8 , Leu 17+ CD 8 , and HLA DR+ CD 8 subsets but not the reciprocal negative CD 8 subsets . ^^^ Thus , changes merely reflective of HIV infection included decreased levels of Leu 8+ CD 4 cells and increased levels of Leu 8 CD 8 , Leu 18 CD 8 , Leu 7+ CD 8 , Leu 17+ CD 8 , and HLA DR+ CD 8 cells . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Peripheral blood mononuclear cells were quantified for the subsets of CD 4 , CD 8 , and CD 19 lymphocytes by using CD45RA ( 2H4 ) , CD 29 ( 4B4 ) , CD 57 , CD 5 , CD 10 , Leu 8 , HLA DR , and TCR gamma delta 1 monoclonal antibodies and dual color immunofluorescence . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
The other surface markers including classical sialyl Le ( 10 ) antigen defined by SNH 3 or FH 6 and LFA 1 , VLA 4 , CD 4 , CD 25 , ICAM 1 , Leu 8 , and HLA DR did not show a significant difference regardless of skin involvement . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
In order to better define changes in the relative proportion of peripheral blood T lymphocyte subpopulations in patients with inflammatory diseases of the bowel , we performed simultaneous three color fluorescence activated cytometric ( FACS ) analysis using fluorophore conjugated monoclonal antibodies with specificity for CD 4 , CD 8 , Leu 8 , and CD45RA on 22 normal control subjects , 28 patients with Crohn ' s disease ( CD ) , 15 patients with ulcerative colitis ( UC ) , and 11 patients with intestinal inflammation secondary to etiologies other than inflammatory bowel disease ( NIBD ) . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
CD 3 , CD 4 , CD 8 , CD11b , CD 16 , CD 25 , CD 57 , Leu 8 HLA DR were compared . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Analysis of purine metabolic enzymes in human CD 4 Leu 8 and CD 4 Leu 8+ lymphocyte subpopulations . 1 . ^^^ CD 4 Leu 8 ( helper / inducer ) and CD 4 Leu 8+ ( suppressor / inducer ) subpopulations were obtained by panning or fluorescence activated cell sorting techniques using specific monoclonal antibodies . 3 . ^^^ A 45 % decrease of 5 ' NT AMP activity in the CD 4 Leu 8 cells ( suppressor / inducer ) compared with CD 4 total cell population . 4 . ^^^ These results suggest that the distribution of purine metabolic enzymes is homogeneous in CD 4 Leu 8 and CD 4 Leu 8+ T lymphocyte subpopulations . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Responders showed several characteristic features compared to non responders as follows : the duration of RA was significantly shorter , the anatomical stage was earlier , the positive rate of susceptible HLA DR 4 haplotype associated with Japanese RA ( DRB1 * 0405 ) was lower , and the proportion of CD 4 + Leu 8 + lymphocytes and the ratio of CD4+ cells to CD8+ cells ( CD+ / CD8 ratio ) in the peripheral blood were higher throughout the treatment period and increased further even after the course of therapy . ^^^ The proportion of CD 4 + Leu 8 + cells was inversely correlated with HAQ and VAPS , suggested that it is critically involved in the mechanism of this therapy . ^^^ Blood leukocyte analysis at inlet and outlet of the filter showed increase of CD 4 + , CD 4 + Leu 8 + cell percentages and CD4 / CD8 ratio . ^^^ These results suggested that patients with a shorter disease duration , less destruction of the joint , and without susceptible genes were more responsive to this therapy and that the mechanism of clinical improvement of RA by LP with cotton wool involves immunological modification , such as immunosuppression by CD 4 + Leu 8 + lymphocytes . . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
A significant decrease of CD 20 , CD 19 , CD 16 , gamma / delta , CD 4 @ leu 8 and increase of CD 3 and CD4+ / leu8+ was found in the lamina propria lymphocyte subsets . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
Here we demonstrate ( by three and four color flow cytometry ) that this depletion is specific to a definable subset of CD 4 ( + ) T cells , namely , those having both a highly and / or acutely activated ( CD 69 ( + ) CD 38 ( + ) HLA DR ( + ) ) and memory ( CD45RA ( ) Leu 8 ( ) ) phenotype . ^^^
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P14151 and P01730	Pubmed	SVM Score :0.0
NA