Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.53768193
We show now that CD 45 associates with lck independently of both CD 4 and CD 8 . 0.53768193^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :1.0698985
We demonstrate that CD 45 is physically associated with CD 4 in resting , primary lymph node T cells . 1.0698985^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.66276116
Whereas the association of CD 4 with CD 45 has been reported , the associations with CD 71 and CD 98 have not been previously described . 0.66276116^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.57117458
The kinetics of association between CD 4 or CD 8 and CD 45 was measured by fluorescence resonance energy transfer and confirmed by immunoprecipitation of dithiobis succinimidylpropionate or disuccinimidyl suberate cross linked 125I labeled resting or activated T cells . 0.57117458^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.53726048
Antibody mediated coclustering of CD 45 with CD 4 inhibited the anti CD 4 induced phosphorylation of p56lck on tyrosine and the concomitant increase in in vitro kinase activity . 0.53726048^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.66987156
Using this panel of transfectants , it is clear that the interaction between CD 4 and CD 45 does not require the cytoplasmic domains of CD 45 , but is dependent on the specific external domain of the various isoforms : low molecular weight species were more likely to associate with the CD 4 TCR complex than the higher molecular weight isoforms , and their ability to coassociate correlated with the magnitude of the response to specific antigen . . 0.66987156^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.50438853
Differential association of CD 45 isoforms with CD 4 and CD 8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction . 0.50438853^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In addition , they expressed CD 45 antigen and T cell antigens ( CD 2 , CD 4 ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Some of the major sheep antigens , including CD 5 , CD 4 , CD 8 , SBU T 19 , Pgp 1 , LCA and the MHC antigens , are described in detail . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
These included CD 3 , CD 4 and CD 8 for T cell subsets , CD 19 and CD 16 for B lymphocytes and NK cells , and CD 45 for leukocyte common antigen ( LCA ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
T cells were identified by antibodies to leukocyte common antigen , as well as the CD 4 and CD 8 surface proteins . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Here we examine the role of CD 4 , CD 8 , CD 2 , and CD 45 in the regulation of intracellular Ca2+ levels in mature and immature thymocytes . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
No cytokines induced CD 3 , CD 4 , CD 23 , CD 25 or CD 45 RA antigen expression in organ culture . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 4 and CD 8 T lymphocytes can be further subdivided using antibodies to isoforms of CD 45 with restricted cellular distributions . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In contrast , the enhancing effect of co crosslinking CD 4 on CD 3 responses was not inhibited by co crosslinking CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Stimulation was not blocked by CD 4 , CD 5 , CD 6 , CD 7 , or CD 45 MoAbs , despite high levels of expression of these antigens on the TCC . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
These were evenly divided between the CD 4 , CD 8 alpha+ and the CD 4 , CD 8 subsets , and rarely expressed the B 220 epitope of CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Signaling through the TcR CD 4 D8 lck CD 45 complex is thought to be insufficient to activate T lymphocytes . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 4 and CD 8 lymphocytes expressed the CD 45 isoforms alone ( CD45RA+ or CD45RO+ ) or in combination CD45RA+RO+ ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In this review we consider the involvement of CD 4 , CD 8 , and CD 45 on the two lymphocyte lineages . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
T cell signaling occurs through the T cell receptor CD 3 complex and is augmented by cosignaling via CD 4 , CD 8 , and CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Cells were labeled with a panel of monoclonal antibodies : anti CD 3 , CD 4 , CD 8 , CD 14 , CD 20 , CD 45 , and CD 56 , and analyzed by cytofluorometry . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Phenotypically pig LP T cells are a homogeneous population and the majority of CD 4 T cells express the low molecular weight isoform of CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The CL 1 cells were positive for CD 45 and MHC class 2 and negative for CD 4 , CD 5 , CD 8 , Thy 1 and B cell specific antigen and surface immunoglobulin . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
They were positive for CD 4 , CD 56 , and also CD 45 , CD 43 , and HLA DR . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 3 , CD 45 RO , CD 4 , CD 8 , CD 16 expression on peripheral blood lymphocytes were studied using flow cytometry . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
This study explored and characterized the effects of thermal exposure on antibody labeling using CD 4 and CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The neoplastic cells were positive for cytoplasmic CD 3 , CD 4 , CD 7 , CD 43 , CD 45 , and CD 56 and were negative for surface CD 3 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In addition to microglia / macrophages , infiltrating leukocytes expressing CD 45 or CD 4 were also detected . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Clonal expansions in acute EBV infection are detectable in the CD 8 and not the CD 4 subset and persist with a variable CD 45 phenotype . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Despite an increase in CD 3 ( + ) , CD 4 ( + ) , and CD 8 ( + ) cells , CD 4 ( + ) CD 45 RA naive lymphocytes were not regenerated . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
PBMC were incubated with mAb against porcine CD 3 , CD 4 , CD 8 , CD 25 , CD 45 , IgM , SWC 3 , and SLA Class 2 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The cell surface markers CD 2 , CD 3 , CD 4 , CD 7 , CD 8 , CD 19 , and CD 45 were studied for the lymphocyte sub population analysis . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Immunohistology was performed using monoclonal mouse anti rat antibodies against CD 4 , CD 8 , CD 25 , CD 45 and CD 54 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The studied antigens were the following : CD 3 , CD 4 , CD 8 , CD 14 , CD 19 , CD 25 , CD 38 , CD 45 , CD45RO , CD 54 , CD 56 , CD62L , CD 71 and HLA DR . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Cultured PBD 1 marrow produced more CD 90 ( br ) MY ( br ) CD 45 ( dim ) CD 4 ( ) MHCII ( ) CD11b ( dim ) eosinophils than did sham . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The development of thymocytes in CD 45 knockout mice is blocked partially in the maturation of CD 4 ( ) CD 8 ( ) to CD 4 ( + ) CD 8 ( + ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Monoclonal antibodies to porcine CD 1 , CD 2 , CD 4 , CD 8 , CD 45 and IgM were used for immunohistochemical staining . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
These patients experienced delayed T cell recovery , particularly in the nave ( CD 45 RA+ ) CD 4 compartment . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Down regulation of CD 45 expression on CD 4 T cells during acute renal allograft rejection : evidence of a decline in T suppressor / inducer activity . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The immature cells ( double positive ) expressed CD 2 , CD 5 , CD 7 , CD 4 , CD 8 , heterogeneous surface CD 3 , and intermediate density CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Age associated changes in glycosylation of CD 43 and CD 45 on mouse CD 4 T cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Flow cytometry showed that the peripheral blood was positive for CD 4 , CD 11 , CD 13 , CD 14 , CD 33 , CD 45 , and HLA DR . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Biochemical analysis reveals that CXCR 4 and LFA 1 are recruited to lipid rafts upon CD 4 but not CD 45 engagement . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The sections were studied on H & E and CD 68 , CD 45 , CD 4 , CD 8 , CD 20 staining . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Tumor cells were positive for CD 45 , CD 43 , CD 4 , and CD 56 ( 9 of 10 ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 4 ( + ) and CD 8 ( + ) cells also exhibited significant changes ( P < 0 . 05 ) in expression of CD 45 isoforms . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Areas of positive staining for HLA DR , HLA DQ , HLA DP , CD 45 , CD45RA , CD45RO , CD 4 , CD 8 , and CD 79 were calculated . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Panleucogating protocol ( PLG ) , requires two antibodies only , CD 45 and CD 4 , or three if CD 8 is requested for special clinical reasons . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Immunohistochemical studies showed the presence of Ki 1 antigen , IL 2 receptor antigen , leukocyte common antigen ( LCA ) , CD 3 and CD 4 on the tumor cells compatible with Ki 1 positive anaplastic large cell lymphoma . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Cells were analysed for T cell subset markers CD 4 ( mAb W3 / 25 ) and CD 8 ( mAb OX 8 ) , for IL 2R ( mAb OX 39 ) , and for high molecular mass leukocyte common antigen ( LCA , CD45RB ) expression ( mAb OX 22 ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Purified allogeneic CD 8 T cell responses were more susceptible to inhibition than purified CD 4 cell responses , but no difference in the inhibition of the CD45RA ( CMRF 11 ) or CD45RO ( UCHL 1 ) LCA positive T cell subsets was observed . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Immunoperoxidase showed tumor cells to be strongly reactive for Leu M 1 ( CD 15 ) , BER H 2 ( CD 30 ) , Leu 3 ( CD 4 ) , and T 11 ( CD 2 ) and weakly reactive for Leu 4 ( CD 3 ) but nonreactive for EMA , LCA , lysozyme , Leu 9 , Leu M 3 , Leu M 5 , and immunoglobulin light chains . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Another antibody , 20 96 , identified an epitope of LCA expressed mainly on B cells , but also on a unique lymphocyte subset contained mostly in peripheral blood , which was 20 96high , sIg , CD 4 , CD 8 , SBU T 19 , but CD5+ . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
To examine the relationship between the microglia and the family of dendritic antigen presenting cells ( APC ) , normal white matter from eight normal adults with no neurological disease at autopsy was examined by immunocytochemical techniques to localize antibodies to leukocyte common antigen ( LCA ) , HLA DR , CD 1 ( T 6 ) , CD 4 ( T 4 ) , and glial fibrillary acidic protein . ^^^ The normal microglia are ATPase +ve , NSE ve , ACP ve , HLA DR +ve , LCA +ve , CD 1 ( T 6 ) +ve and weakly CD 4 ( T 4 ) +ve . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In 1988 , two major leukocyte differentiation antigens , CD 10 ( cALLA ) and CD 45 ( LCA , T 200 ) , were shown to be enzymes while two other markers , CD 4 and CD 8 , were found to be associated with an enzyme . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Tissue sections were tested by peroxidase antiperoxidase method , using the following monoclonal antibodies : OX 19 ( CD 5 ) , W3 / 25 ( CD 4 ) , OX 8 ( CD 8 ) , OX 6 ( Ia ) , OX 33 ( LCA ) and OX 39 ( CD 25 ) . ^^^ Few T lymphocytes ( CD5+ ) were found in arthritic synovial membrane , whereas an increase of cells expressing CD 8 , CD 4 , CD 25 , Ia , and LCA was found . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
An increase in the number of microglial processes and in immunoreactive staining was observed with antibodies directed against CR 3 , MHC 1 , CD 4 , and rat LCA . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Immunohistochemical analysis was performed using monoclonal antibodies that recognize framework determinants of either HLA class 1 or HLA class 2 or leukocyte differentiation antigens ( LCA , CD 3 , CD 4 , and CD 8 ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In contrast , we observed that the localization of CD 4 , CD 3 , T cell restricted intracellular antigen ( TIA ) , and leukocyte common antigen ( LCA ) was restricted to lymphocytes in CD patients . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Immunohistochemistry revealed that the tumor cells were positive for LCA , CD 3 , TIA 1 and granzyme B , but were negative for CD 4 , CD 8 , CD 56 , CD 30 , L 26 , EMA , TCR alpha / beta and TCR gamma / delta . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Twenty seven JXG , ten dermatofibromas ( DF ) , and ten age matched normal skin specimens were stained using standard immunohistochemistry methods , and all JXGs were fascin+ and CD68+ , although 26 of 27 were reactive for HLA DR , 25 of 27 for Factor XIIIa , 25 of 27 for LCA , 21of 27 for CD 4 , and 8 of 27 for polyclonal s 100 . ^^^ Eight of ten dermatofibromas were FXIIIa+ ; all were negative for HLA DR , LCA , CD 4 , and polyclonal s 100 . ^^^ We would also conclude that neither Factor XIIIa nor S100+ results should preclude the diagnosis of JXG , and find that reactivity for CD 4 and LCA may be used to distinguish JXG from DF when the latter is heavily lipidized or the former is not . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Microglial cells were visualized by immunolabeling of proteins which are known to be expressed either constitutively or facultatively , such as CD 68 , major histocompatibility complex class 2 ( MHC 2 ) , leukocyte common antigen ( LCA ) , leukocyte chemotactic factor ( LCF ) , macrophage inhibitory factor related protein ( MRP ) 8 , MRP 14 , CD 4 and allograft inflammatory factor 1 ( AIF 1 ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The epithelioid cells are LCA positive , expressing cytoplasmic CD 3 diffusely and TIA 1 focally , but negative for EMA , CD 4 , CD 8 , CD 15 , CD 20 , CD 30 , and CD 56 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Immunohistochemical staining revealed that these atypical lymphoid cells were positive for LCA , CD 45 , CD 5 , CD 20 , CD 3 epsilon , CD 8 , bcl 2 and bcl 6 and negative for CD 56 , CD 4 , CD 68 , keratin , S 100 , kappa and lambda . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
All cases were reactive for LCA , CD45RO , and CD 68 ( KP 1 and PG M 1 ) ; 13 of 14 ( 93 % ) expressed CD 4 , 12 of 14 ( 86 % ) lysozyme , 8 of 10 ( 80 % ) CD 31 , 7 of 14 ( 50 % ) S 100 protein , and 5 of 14 ( 36 % ) focal CD1a . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
However , they showed unequivocal expression of both CD 30 and CD 15 , and no aberrant antigen expression to suggest ALCL ( BSAP+ , EMA , LCA , CD 43 , CD 2 , CD 3 , CD 4 , CD45RO , ALK , granzymeB ) , with negative TCR gene rearrangement and no expression of EBV . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Using specific monoclonal antibodies and flow cytometry , both macrophages and endothelial cells were found to express cell surface markers for Ia antigen , leukocyte common antigen , CD 4 and the macrophage antigen , ED 2 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Using a panel of monoclonal antibodies ( mAbs ) , we have examined the time course of expression of major histocompatibility complex ( MHC ) antigens class 1 ( OX 18 ) and class 2 ( OX 6 ) , leukocyte common antigen ( OX 1 ) , CD 4 ( W3 / 25 ) and CD 8 ( OX 8 ) antigens , CR 3 complement receptor ( OX 42 ) , as well as brain macrophage antigen ( ED 2 ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The expression of leukocyte common antigen , and CD 4 and CD 8 antigens was conspicuous throughout the tumor , and associated with lymphocytes , perivascular cells , and microglia . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
High and low molecular weight variants ( CD45R ) of the leukocyte common antigen ( CD 45 ) divide CD 4 T helper cells into subpopulations which display distinct characteristics . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
We have examined the microglial reaction accompanying motor neuron death following sciatic nerve crush in the newborn rat using lectin staining with the Griffonia simplicifolia B 4 isolectin , as well as immunocytochemistry with a panel of monoclonal antibodies directed against brain macrophage antigen ( ED 2 ) , and various immunologically important surface molecules ( immunomolecules ) , such as major histocompatibility complex ( MHC ) class 2 ( Ia ) antigen ( OX 6 ) , CR 3 complement receptor ( OX 42 ) , CD 4 antigen ( W3 / 25 ) , and leukocyte common antigen ( OX 1 ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Such macrophages also expressed CD 4 ( Leu 3a and 3b ) and 2H4 , which are the cell membrane determinants of suppressor inducer T lymphocyte ; CD 2 ( Leu 5b ) , which is a marker of pan T cell ; Leu M 3 , Leu M 5 and Mac 1 , which are the markers of monocyte and macrophage lineage ; leukocyte common antigen , which is a marker of bone marrow derived cell ; and alpha antichymotrypsin , which is a glycoprotein associated with macrophages . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
As well as anti HLA DR , the whole infiltrate was recognized by three of the antibodies in the panel studied : RFD 1 , reported to be an antibody to ' dendritic cells ' , leu3a which recognizes CD 4 ( an antigen expressed on helper / inducer T cells and macrophages ) , and PD7 / 26 which recognizes the leukocyte common antigen . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 4 T cells bearing high ( 240 190 kDa ) and low ( 180 kDa ) molecular mass isoforms of the leukocyte common antigen CD 45 define functionally distinct subsets which have been equated with naive and memory T cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Flow cytometric analysis revealed that these cells were CD 3 , CD 4 , CD 8 , and B 220 , but strongly expressed CD 45 ( leukocyte common antigen ) , and mild to moderate levels of CD11b , heat stable antigen , and CD 44 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The results showed a large population of spindle shaped cells that expressed the immunophenotype of a tissue macrophage , that is , Leu 3a , b ( CD 4 ) + , MY 7 ( CD 13 ) + , Leu M 5 ( CD11c ) + , KP 1 and EBM 11 ( CD 68 ) + , human leukocyte antigen ( HLA DR ) + , leukocyte common antigen ( CD 45 ) + , HAM 56+ , and MAC387+ . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
During the subsequent cycle , in the presence of numerous T cells , regressing GLC exhibited strong surface expression of various macrophage markers , such as CD 4 , CD 14 , CD 68 , and leukocyte common antigen , a feature not detected in the CL during the luteal phase nor described in other tissues . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
With time in culture and with different schedules , depending on the parameter considered , microglia acquired antigenic ( e . g . , positivity for vimentin , ED 1 , major histocompatibility complex class 1 antigens , leukocyte common antigen , and to a lesser extent CD 4 ) and functional ( e . g . , proliferation , phagocytosis ) features characteristic of `` activated ' ' microglia as described in situ . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Persisting GLC lacked surface expression of macrophage markers ( CD 4 , CD 14 , CD 68 and leukocyte common antigen ) as well as nuclear granules exhibiting CD 15 of neutrophils , detected in regularly regressing GLC . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Quantitative immunohistochemistry analyzing a panel of immune cell types , including T lymphocytes , T helper / inducer cells ( CD 4 ) , T suppressor / cytotoxic cells ( CD 8 ) , T cells positive for interleukin 2 receptor ( CD 25 ) , B lymphocytes and plasma cells , macrophages , natural killer cells , granulocytes and all leukocytes expressing the leukocyte common antigen ( CD 45 ) , yielded no evidence for the ability of VAA to stimulate a substantial cellular immunological reaction in the wall of the normal urinary bladder or during urothelial carcinogenesis . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 56 , CD45RO ( UCHL 1 ) , CD 43 ( MT 1 ) , CD 45 ( leukocyte common antigen ) , and the cytotoxic molecules perforin , granzyme B and TIA 1 were positive , but CD 20 ( L 26 ) , CD 4 , CD 8 , and betaF 1 were negative . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
A small fraction of rat 13 day old fetal liver ( r13FL ) cells , which weakly expressed the leukocyte common antigen CD 45 , constituted a homogeneous Thy 1 ( hi ) , CD 71 ( ) , CD 44 ( + ) , MHC class I+ , CD 43 ( + ) cell subpopulation negative for CD45RC , CD 3 , TCRalphabeta , TCRgammadelta , CD 2 , CD 5 , CD 4 , CD 8 , CD 25 , CD 28 , NKR P1a and sIg . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
They were also focally positive for CD 68 and CD 4 , but were uniformly negative for leukocyte common antigen , CD1a , CD 3 , CD 20 , CD 21 , CD 23 , CD 34 , CD 35 , actin , desmin , HMB 45 , cytokeratins , and placental alkaline phosphatase . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Immunoreactivities were compared to those of different monoclonal markers against endothelial cells ( HIS 52 , CD 31 ) , histiocytes ( ED 1 , ED 2 ) , dendritic cells ( Ox 62 ) , granulocytes ( HIS 48 ) , B cells ( RLN 9D3 ) , T cells ( Ox 52 ) , CD 4 ( Ox 35 ) , CD 8 ( Ox 8a ) , natural killer cells ( 10 / 78 ) , and CD 45 ( Ox 1 , leukocyte common antigen ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Immunophenotypically , the neoplastic cells were positive for CD 30 , CD 4 , leukocyte common antigen , anaplastic lymphoma kinase 1 , epithelial membrane antigen , and granzyme B . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Cell surface molecules other than CD 4 , including TCR , CD 3 , CD11a , CD 2 , CD 45 , CD 44 , and MHC class 1 , remained identical on D10H and D10L sublines as on D 10 wild type cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In addition , the organization of their TCR is altered , with increased levels of the TCR eta chain and an increase in the extent of association of CD 4 with CD 3 and CD 45 , changes similar to those found in Th 1 cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In strong contrast to these results , co clustering of CD 4 with CD 45 did not result in any detectable intracellular phosphotyrosine at the cap sites . ^^^ These data indicate that CD 45 can act on CD 4 associated phosphoproteins in viable human T lymphocytes . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The machinery which couples the TcR / CD3 complex , CD 4 , and CD 45 to PI PLC appears to involve regulation of tyrosine phosphorylation , as the TcR / CD3 and CD 4 receptors are associated with the tyrosine kinases p59fyn and p56lck , respectively , and CD 45 has intrinsic tyrosine phosphatase activity . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Flow cytometry showed the T 412 cells to be positive for the T cell markers CD 45 , CD 38 , and CD 4 but negative for all other markers tested . ^^^ The E88 / RF cells are positive for CD 45 and CD 38 but negative for CD 4 and other markers . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The 180 and 190 kDa isoforms of CD 45 are preferentially expressed on the helper inducer ( memory ) subset of CD 4 cells . ^^^ These results suggest that the 190 kDa CD 45 isoform on human CD 4 cells is heterogeneous and that the 190 kDa isoform recognized by anti 4H2D regulates the function and activation of CD 4 helper T cells . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In this report , analysis of naive and memory CD 4 T cells , separated on the basis of CD 45 isoform expression , has shown that their requirements for two signals differ . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
To determine whether progesterone causes a change in lymphocyte subpopulations in the endometrium , frozen sections of intercaruncular and caruncular endometrium from ewes receiving daily i . m . injections of 100 mg / day progesterone were evaluated by immunohistochemistry for the presence of lymphoid cells bearing CD 45 , major histocompatibility complex ( MHC ) class 2 , CD45R , CD 4 and CD 8 antigens . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Co aggregation of CD 4 or CD 8 p56lck kinase with the TCR in CD 45 cells restored TCR induced protein tyrosine phosphorylation , phospholipase C gamma 1 regulation and calcium signals . ^^^ These results indicate that CD 45 regulated p59fyn plays a critical role in coupling the TCR to specific intracellular signalling pathways and that CD 4 or CD 8 p56lck can only restore signal transduction coupling in CD 45 cells when brought into close association with the TCR . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 5 , CD 15 and CD 45 antigens were detected at 6 weeks of gestation , whereas CD 4 , CD 8 , CD 10 , CD11c , CD 14 and IgM were not expressed at this stage . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Both normal and WAS T cell lines express cell surface molecules CD 2 , CD 3 , T cell receptor alpha / beta , human histocompatibility leukocyte antigen class 1 , CD 45 and CD11a , and varying ratios of CD 4 and CD 8 , and are negative for natural killer cell and monocyte surface molecules . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
MRL lpr / lpr ( lpr ) mice develop a polyclonal accumulation of abnormal peripheral T lymphocytes , which bear surface alpha beta TCR , CD 3 , and the B 220 isoform of CD 45 , but lack CD 4 , CD 8 , and CD 2 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 45 appeared to be associated with the CD3 / T cell receptor complex and with CD 4 or CD 8 molecules in memory , but not in naive T cells , as previously reported in the mouse . ^^^ Further information on the CD 45 isoform ( s ) associated to CD 4 and CD 8 was sought by assessing the isoform specificity of MCA . 347 . ^^^ In conclusion , this work shows that in human T cells different CD 45 isoforms are associated to different surface molecules : LFA 1 is associated to CD45RA , CD 2 to CD45R0 and CD 4 and CD 8 presumably to CD45RC . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Interaction of CD 4 : lck with the T cell receptor / CD3 complex induces early signaling events in the absence of CD 45 tyrosine phosphatase . ^^^ In normal T cells , CD 3 mediated PLC activation is significantly augmented by co ligation of CD 3 with the CD 4 co receptor ; however , unlike CD 3 associated tyrosine kinases , antibody induced activation of the CD 4 associated tyrosine kinase p56lck does not require CD 45 expression . ^^^ To explore the role of CD 45 in the CD 3 and CD 4 activation pathways further , we examined the effect of CD3 / CD4 cross linking on tyrosine phosphorylation and activation of phospholipase C in CD 45 mutant cells of the T cell leukemia line HPB . ^^^ However , we show here that ligation of CD 3 with CD 4 leads to tyrosine phosphorylation of PLC gamma 1 and elevation in the intracellular free Ca2+ concentration in CD 45 cells that is in excess of that seen in CD45+ cells . ^^^ Since CD 4 stimulation alone did not activate PLC , a component of the CD 3 signaling pathway must be independent of CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Regulation of CD 3 induced phospholipase C gamma 1 ( PLC gamma 1 ) tyrosine phosphorylation by CD 4 and CD 45 receptors . ^^^ Here we show that cross linking of CD 4 molecules with CD 3 augments the tyrosine phosphorylation of PLC gamma 1 , while co ligation of CD 3 with CD 45 ( a receptor tyrosine phosphatase ) results in reduced PLC gamma 1 tyrosine phosphorylation . ^^^ A 35 , 000 / 36 , 000 MW tyrosine phosphorylated protein in T cells formed stable complexes with PLC gamma 1 , and its tyrosine phosphorylation was co regulated with that of PLC gamma 1 by CD 4 and CD 45 receptors . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The three main components are the hypervariable alpha : beta heterodimer that confers specificity and its attendant invariant chains CD 3 gamma , delta , and epsilon and the zeta : zeta or zeta : eta , the CD 4 or CD 8 coreceptor , and CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The phenotypes of isolated cells were characterised for expression of CD 45 , CD 3 , CD 4 , CD 8 , CD 14 , CD 15 , CD 68 , CD 22 , CAM 5 . 2 and class 2 MHC antigens and compared with those in situ in frozen sections of the same placentas . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Tumor cells within subtotally effaced lymph nodes had positive findings for CD 45 , CD 4 , CD 7 , and LN 2 and negative findings for CD 3 , CD 8 , and beta F 1 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Using irradiation chimeras , we show that resident microglia respond to inflammation by upregulating CD 45 , CD 4 , and MHC class 1 molecules with a minority of these cells increasing their expression of MHC class 2 molecules . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Immunophenotypic ( CD 3 , CD 4 , CD 8 , CD 34 , and CD 45 RO ) and cytogenetic ( deletion of the Y chromosome and chromosome 9 ) abnormalities were found , together with monoclonal T cell receptor gene rearrangements . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
High levels of CD 45 are coordinately expressed with CD 4 and CD 8 on avian thymocytes . ^^^ The shift from low to high levels of surface CD 45 expression therefore occurred at the same stage as the transition from CD 4 8lo to CD4+8+ and before the expression of CD 3 . ^^^ The protein tyrosine kinase activity associated with CD 4 and CD 8 ( p56lck ) and the phosphatase activity of CD 45 have been implicated elsewhere in jointly regulating peripheral T cell signal transduction and subsequent cellular responses . ^^^ The coordinated expression of high levels of CD 45 with both CD 4 and CD 8 in the avian thymus supports the possibility that these molecules may function together in regulating thymocyte growth and / or differentiation . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The impact of AFP on the expression of surface markers ( MHC class 1 and 2 , CD 4 , CD 18 , CD 45 , Fc receptors for IgG ) was analyzed using known inducers of monocyte macrophage differentiation such as phorbol esters and IFN gamma . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Utilizing the approach of heterologous receptor aggregation , we also showed that CD 45 could inhibit the induction of MAP 2K activity in intact Jurkat cells during CD 3 or CD 3 + CD 4 stimulation . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 45 isoforms associated with distinct functions of CD 4 cells derived from unusual healthy donors lacking CD45RA T lymphocytes . ^^^ Furthermore , biochemical analysis of the distribution of individual CD 45 isoforms on the surface of these subsets of CD 4 cells revealed distinct differences . ^^^ These results suggest that despite the superficial phenotypic similarity of CD 4 cells in these donors , distinctions in the distribution of both CD 29 and the 180 and 220 kDa CD 45 isoforms exist and might play a role in the different functions of freshly isolated CD 4 lymphocytes . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The cellular infiltrates for the surface phenotypic markers for alpha / beta and gamma / delta T cell receptors , CD 4 , CD 8 , CD 45 , and CD 5 were examined in lip biopsy specimens from two patients with primary Sjgren ' s syndrome , six with secondary Sjgren ' s syndrome , and seven healthy controls . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Marked differences were found in the percentage and distribution of lymphocyte subsets ( CD 5 , CD 4 , CD 8 , T 19 , CD 45 , and CD45R cells ) in hemal nodes compared to those in mesenteric lymph nodes and blood . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
FDCs contain a very restricted mRNA pattern with high levels of message for the C3d receptor ( CR 2 , Epstein Barr virus / EBV receptor , CD 21 ) and lack of mRNA for CD 20 , CD 45 , CD 4 , fibronectin , and platelet derived growth factor receptor alpha and beta . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In contrast , CD 4 crosslinking with DR enhanced the ( Ca2+ ) 1 responses , but the inhibitory effect of CD 45 dominated over the enhancing effect of CD 4 . ^^^ This conclusion is consistent with our observation that in activated human T cells , class 2 signals are up regulated by CD 4 , which is associated with p56lck , and down regulated by CD 45 , which is a tyrosine phosphatase . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD3 / Ti signaling in normal T cells was also inhibited by CD 45 ligation , but coupling of CD 4 with CD3 / Ti gave augmented calcium signals that were entirely resistant to the inhibitory effect of CD 45 . ^^^ In contrast , CD 3 induced T cell proliferation was suppressed by immobilized CD 45 mAb even in the presence of CD 4 mAb . ^^^ The effect of CD 45 and CD 4 ligation on tyrosine phosphorylation during T cell activation was directly examined by immunoblotting with anti phosphotyrosine . ^^^ Simultaneous ligation of CD 3 and CD 4 enhanced tyrosine phosphorylation of all substrates , but did not overcome the CD 45 mediated suppression of tyrosine phosphorylation of the 35 and 36 kDa proteins . ^^^ The CD 45 mediated suppression of phospholipase C activation is therefore modulated by association with CD 4 without altering the specific inhibition of tyrosine phosphorylation and T cell proliferation after co ligation of CD 45 and CD3 / Ti . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Osteoclast like cells were positive for CD 4 , CD 13 , CD 45 , CD 68 , CD 71 , and vimentin , but negative for lysozyme and HLA DR . ^^^ Mononuclear tumor cells were positive for CD 4 , CD11c , CD 13 , CD 14 , CD 45 , CD 68 , CD 71 , HLA DR , and vimentin , but negative for lysozyme . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Different isoforms of CD 45 are expressed on naive and memory CD 4 T cells in the mouse , as revealed by an antibody to a set of isoforms of CD 45 that utilize exon B , called CD45RB . ^^^ On naive T cells , CD 4 , CD 45 and the CD3 / T cell receptor complex behave as independent entities . ^^^ Furthermore , on TH 2 cells , which express intermediate levels of CD45RB , CD 4 is stably associated with CD 45 isoforms other than CD45RB , but this complex is not associated with the CD3 / T cell receptor . ^^^ These results lead us to propose that immunological memory in CD 4 T cells consists of an altered structure of the T cell ' s specific signal transduction apparatus controlled by low molecular weight CD 45 isoforms . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The thymocytes defined by their lack of CD 45 p180 , the low molecular mass isoform , comprise all thymocytes with clonogenic potential and include all major subsets defined by CD 4 and CD 8 . ^^^ Negative depletion methods were used to isolate and characterize human thymocyte subsets defined by CD 45 isoform , CD 3 , CD 4 , and CD 8 , and subsequently to determine the cell cycle status of the isolated subsets by flow cytometric analysis of cellular DNA content . ^^^ CD 45 p180 cells , as well as the CD 4 ( 8 ) and CD 3 ( 4 ) ( 8 ) subsets , which express high molecular weight CD 45 isoforms , exhibited a significant number of cycling cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
A majority of the cells from peripheral blood coexpressed the antigens against MAbs CD 2 , CD 3 , CD 4 , CD 5 , Ti ( WT 31 ) , CD 25 , CD 38 , CD 45 , and CD 29 , but did not express the antigens against CD 1 , CD 13 , CD 14 , CD 33 , CD 36 , CD 10 , CD 19 , CD 20 , CD 21 , CD 24 , CD 41 , CD 42 , CD45RA , CD 56 , and CD 57 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The spindle shaped cells stained positively for numerous macrophage markers including CD 45 , factor XIIIa , Leu M 5 , HLA DR , CD 4 , and Leu M 3 , consistent with dermal dendrocytes . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In this article , Barton Haynes and colleagues discuss the sequential expression of CD 7 , CD 4 , CD 8 , CD 3 , CD 2 , CD 1 , CD 45 , TCR gamma delta and TCR alpha beta , and propose a model defining the stages of T cell precursors during fetal ontogeny . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The relationship between surface molecule expression and encephalitogenicity of myelin basic protein ( BP ) sensitized cells induced by three different sensitization protocols was studied using adoptive transfer in Lewis rats . ( 1 ) In BP / CFA sensitization , CD4+ blastoid T cells showing marked upregulation of CD 4 , class 1 and 2 MHC , and IL 2 receptor molecules , but not CD 5 , CD 8 , or CD 45 , were generated after culture with BP . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Crosslinking of CD 2 , CD 4 and CD 45 with Ti / CD3 to several of these antigens can augment the minimal signal induced by antigen binding to the Ti / CD3 complex . ^^^ Importantly , some of these regulatory structures ( CD 4 , CD 8 and CD 45 ) are also expressed on subsets of T cells with distinct activation requirements and functional programs ( helper , suppressor , suppressor inducer and cytotoxic function ) . ^^^ Crosslinking of CD 4 with the Ti / CD3 complex preferentially activated the CD4+ CD45+ RA subset , while soluble antibodies to CD 2 preferentially affected the CD 45 CD45RA+ subset . ^^^ The regulatory role of the CD 4 , CD 8 and CD 45 antigens may be mediated by an interactive network of protein tyrosine phosphorylation and dephosphorylation . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
These data demonstrate that CD 4 T cells in normal mice are already functionally committed , and that they differentially express forms of CD 45 that contain the second variable exon . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In addition biopsies were stained with a panel of monoclonal antibodies reacting with CD 45 , CD 3 , CD 4 , CD 8 , EBM 11 ( a monocyte macrophage marker ) , HLA DR , DP , and DQ , using the usual indirect immunoperoxidase method . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
These immature cells are TdT and do not express membrane CD 3 ( mCD 3 ) or TCR beta identified by beta F 1 , but show CD 7 and CD 45 positivity without CD 1 , CD 2 , CD 5 , CD 4 , CD 8 , CD 10 , and class 2 Ag . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In addition , plasmacytoid T cells were positive for CD 4 , CD 45 , HLA class 2 antigens ( HLA DR , Leu 10 , MB 3 , LN 2 , LN 3 ) and the transferrin receptor . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The T 4 ( CD 4 ) subset of T lymphocytes has been subdivided into two major subsets , a suppressor / inducer subset ( T4+ , 2H4+ ) and a helper subset ( T4+ , 2H4 ) on the basis of the differential expression of the L C / T200 ( CD 45 ) antigens . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In contrast , the increase in [ Ca2+ ] 1 induced by formation of homoaggregates of CD 4 was strongly amplified when CD 4 was coupled to CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Through the cross linkage by thiol reactive bivalent mercury , transmembrane CD 4 , CD 3 , and CD 45 and glycosylphosphatidylinositol anchored Thy 1 were aggregated together on thymocytes or T lymphocytes . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Abnormalities which could contribute to this defect include low expression and rapid TCR / CD3 modulation , loss of CD 4 , CD 8 , CD 2 and Ly 6 . 2 , aberrant expression of CD 45 , and constitutive elevations of inositol phospholipid turnover , tyrosine phosphorylation , and expression of the p59fyn protein tyrosine kinase ( PTK ) and a few other protooncogenes . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Immunophenotyping revealed that these cells expressed the leucocyte common antigen CD 45 , and the macrophage markers CD 14 , CD 36 and CD 4 , but not CD11b . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 45 mediated regulation of extracellular calcium influx in a CD 4 transfected human T cell line . ^^^ Treatment of CD 4 wild type transfected cells with either anti CD 45 mAb , EGTA , or PMA rapidly restored the cells to basal levels of intracellular calcium . ^^^ Analysis of CD 45 cross linking on CD4+ and CD 4 normal Jurkat lines demonstrated that CD 4 expression was required for CD 45 mediated inhibition of TCR induced calcium responses . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In addition , although virgin and naive CD 4 cells may be divided based upon their expression of CD45RA or CD45RB , memory CD 8 cells can not be differentiated by their expression of CD 45 isoforms . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Leukocytes and lymphocyte subsets of peripheral blood were determined before , throughout and after subcutaneous injections of G CSF by flow cytometry using monoclonal antibodies to CD 3 , CD 4 , CD 8 , CD 14 , CD16 / 56 , CD 19 and CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Ascites and peripheral blood of 12 patients with advanced ovarian cancer ( stage 4 ) have been investigated by two color flow cytometry for leukocytes and lymphocyte subsets with monoclonal antibodies , against CD 3 , CD 4 , CD 8 , CD 14 , CD16 / 56 , CD 19 , CD 25 , CD 45 , CD 57 , and HLA DR . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
To express its co receptor function fully , CD 4 must be laterally associated with the TCR and CD 45 to form multi receptor complexes competent to transduce potent activation signals . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The major anomalies present during this phase are an increase in the percentage of large thymocytes lacking CD 4 and CD 8 markers and also of small thymocytes express both the T cell marker CD 3 and the B cell specific form of CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 4 and CD 45 regulate qualitatively distinct patterns of calcium mobilization in individual CD4+ T cells . ^^^ Finally , the simultaneous cross linking of CD 45 , CD 3 and CD 4 abrogates the sustained increase in calcium seen following CD 3 and CD 4 cross linking . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Peripheral blood cells were stained by a three color method using monoclonal antibodies conjugated respectively with fluorescein isothiocyanate ( FITC ) CD 3 , phycoerythrin ( PE ) CD 4 and peridinin chlorophyll protein ( PerCP ) CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
During the process of maturation , macrophage precursors gradually lost their MHC class 2 expression , acquired other surface markers ( CD 45 , Thy 1 , CD 25 , CD 4 , etc . ) and increased the acid phosphatase activity . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Mice homozygous for lpr and gld develop lymphadenopathy characterized by the progressive accumulation of an unusual population of CD 4 , CD 8 , CD 2 , IL 2R double negative ( DN ) T cells that express reduced levels of TCR alpha / beta , high levels of CD 45 ( B 220 ) and Ly 6C and variable levels of CD 69 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Flow cytometry analysis revealed that these cells express CD 45 , CD 56 , CD 2 , CD 7 , CD11a , CD 18 , CD 69 and the intermediate affinity ( p 70 ) IL 2 receptor ( IL 2R ) but not CD 57 , CD 16 , CD 3 , CD 4 , CD 5 , CD 8 , CD45RA , CD 25 , or the high affinity p 55 IL 2R . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The T CLL cells coexpressed antigens detected by MAbs CD 2 , CD 3 , CD 4 , CD 5 , Ti ( TcR alpha / beta ; WT 31 ) CD 45 and CD45RA , but did not express any other antigens including CD 1 , CD 8 , CD 29 , and TCR gamma / delta , Ti gamma A and TQ 1 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Activities found in four lots each of horse ATG ( ATGAM , Upjohn ) , rabbit and horse ATG ( thymoglobulin and lymphoglobulin , Merieux ) , horse ALG ( Minnesota ) , and rabbit ATG ( Fresenius ) have been compared for CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD11a , CD 18 , CD 28 , CD 44 , CD 45 , and TCR alpha / beta antigens . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Twenty nine polymorphic markers on 18 different chromosomal locations were investigated , including markers linked to the genes coding for the HLA antigens , the immunoglobulin heavy and light chains , the receptors for the immunoglobulin Fc fragments , the subunits of the T cell receptor and the associated CD 3 , CD 4 , CD 8 , and CD 45 antigens , interleukins 1 , 3 , 4 , 5 , 6 , 9 , and 11 , the interleukin 1 and 2 receptors , and the genes coding for the beta 1 adrenoreceptor , the adenine nucleotide translocator 1 , and the cardiac alpha and beta myosin heavy chains . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Although being CD44+ T cells expressing neither CD 4 nor CD 8 , they are CD 3 T cell receptor ( TCR ) alpha beta positive and express both Thy 1 and B 220 , the B cell form of the CD 45 marker . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 45 is expressed on T cells as distinct isoforms and these isoforms are expressed differentially on subsets of CD 4 T cells . ^^^ We have generated T cell lines expressing a T cell receptor ( TCR ) of known specificity , with or without CD 4 , and examined the effect of different CD 45 isoforms on stimulation through the antigen receptor . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Our results demonstrate that whereas expression of major histocompatibility complex ( MHC ) molecules , CD 45 , Mac 1 , LFA 1 , B cell markers , macrophage markers and some T cell markers ( as CD 2 , CD 4 and CD 8 ) did not undergo changes in culture , the level of expression of the adhesion molecules VLA 4 and ICAM 1 , and the T cell markers CD 5 , CD 25 and Thy 1 increased after 14 h incubation at 37 degrees C . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The following markers were used : common leukocyte antigen ( CD 45 ) , T lymphocytes ( CD 3 ) , monocytes macrophages ( CD 68 ) , and CD 4 and CD 8 lymphocytes . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In contrast , the RATG antibodies that persisted the longest in vivo in the plasma of rhesus monkeys transplant recipients are antibodies to CD 3 , CD 4 , CD 8 , CD11a , CD 40 , CD 45 , CD 54 , and class 1 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The immunophenotype of these tumor cells was usually T cell ( CD5+ or , RT1+ , RT2+ or , CD45+ , CD 4 , RABELA and MHC class 2 DQ+ ) except for Hodgkin like lymphoma cells which expressed only CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Expression of the activation markers CD 25 , HLA DR and VLA 1 and the CD 45 isoforms CD45RA and CD45RO on peripheral blood CD 4 and CD 8 T lymphocytes was measured using dual fluorescence flow cytometry . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
To characterize the cellular composition of the amyloid material , specimens from seven patients treated by maintenance haemodialysis were studied with immunoperoxidase labelling using monoclonal antibodies to leukocytes ( CD 3 , CD 14 , CD 68 , CD 4 , CD 8 , CD 45 ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Serial sections of the grafts were also examined for RT1b , CD 4 , CD4+ , CD 8 , CD11b / c and CD 45 , in order to determine hydrolase activity within infiltrating cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
They expressed cell surface CD 8 , a putative interleukin 2 receptor , CD 45 and a receptor for IgG , but did not express CD 4 , major histocompatibility complex class 2 or immunoglobulin . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Percentages of the different lymphocytes subsets , including CD 2 ( T cells ) ; CD 4 ; CD 45 RA ( suppressor inducer / virgin T cells ) ; CD 4 CD29 ; CD 8 ; CD 19 ( B cells ) as well as interleukin 2 ( IL 2 ) receptor ( CD 25 ) and class 2 antigen ( HLA DR ) expression , were analyzed by flow cytometry . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
We evaluated a flow cytometric method for determining the proportion of CD 4 positive T lymphocytes in whole blood using a single three color tube containing fluorochrome labeled CD 45 , CD 3 , and CD 4 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Antibody cross linking of the tyrosine phosphatase CD 45 with 3 10 4 ( 3 10 4 10 45 ) also inhibited CD 4 augmented phosphorylations and like genistein did not reduce Ca2+ levels . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Blood samples at rest , at 10 min , at end , and 60 min after S 1 or S 2 were taken for immunophenotyping of leukocytes with fluorescein or phycoerythrin conjugated monoclonal antibodies ( CD 3 , CD 4 , CD 8 , CD 14 , CD 16 , CD 45 , CD45RO , CD45RA , CD 69 , HLA DR ) and dual color flow cytometry . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
None of the other cytokines tested ( IL 1 alpha , IL 6 , TNF alpha , IFN alpha , IFN gamma ) supported growth of NK 92 cells which have the following characteristics : surface marker positive for CD 2 , CD 7 , CD11a , CD 28 , CD 45 , CD 54 , CD56bright ; surface marker negative for CD 1 , CD 3 , CD 4 , CD 5 , CD 8 , CD 10 , CD 14 , CD 16 , CD 19 , CD 20 , CD 23 , CD 34 , HLA DR . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The CD 45 tyrosine phosphatase regulates specific pools of antigen receptor associated p59fyn and CD 4 associated p56lck tyrosine in human T cells . ^^^ Using this technique it was shown that cell surface CD 4 p56lck kinase activity was 78 % lower in CD 45 than in CD45+ cells . ^^^ Our results demonstrate that CD 45 selectively regulates the pools of p59fyn and p56lck kinases which are associated with the TCR and CD 4 at the cell surface . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
At the permissive temperature , MegT cells exhibit the characteristics of early 2N and 4N megakaryocytes which include the presence of specific gene products such as PF 4 , glycoprotein IIb , acetylcholinesterase , and CD 45 as well as the absence of molecular markers of other cell lineages such as the macrophage marker Mac 1 , the T helper cell marker CD 4 , the mast cell marker IgE , the T cell marker CD 2 or the erythroid cell marker alpha globin . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Subpopulations of synovial and inflammatory cells were identified with MoAbs against cell surface glycoproteins present on B lymphocytes ( CD 45 ) , T lymphocytes ( CD 2 , CD 4 , CD 8 ) , macrophages ( CD 14 ) and endothelial cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The selection of T lymphocytes in the thymus and their activation upon the encounter with foreign antigens in the periphery require the aggregation and signals of the T cell receptor ( TcR ) / CD3 complex and several surface molecules termed coreceptors ( notably CD 4 or CD 8 and CD 45 ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 4 , CD 8 and the role of CD 45 in T cell activation . ^^^ CD 4 , CD 8 and CD 45 regulate the coupling of the T cell receptor complex ( CD 3 TCR ) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Several groups have reported a physical interaction between distinct isoforms of CD 45 and CD 2 , CD 4 , and the TCR CD 3 complex . ^^^ Given the potential regulatory interaction between CD 45 and PTKs in CD4+ subsets expressing different CD 45 isoforms , we have examined CD 4 associated and TCR CD 3 associated PTK activities , associated phosphatidyl inositol ( PI ) kinases and substrates of tyrosine phosphorylation in CD45RA+ and CD45RA CD4+ T cell lines derived from peripheral blood . ^^^ These observations indicate that despite the possible interaction between CD 45 isoforms and CD 4 or TCR CD 3 , the mere expression of the CD45RA isoform does not in and of itself alter the presence of receptor associated kinases or their intracellular targets . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The human CD 4 population can be divided into functionally distinct and largely reciprocal subsets based on their differential expression of CD 45 isoforms ( CD45RA , CD45RO ) and the CD29 / VLA beta chain . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The principal types of tumors were plasmacytomas secreting immunoglobulin and novel lymphomas that expressed markers such as Sca 1 , CD 4 , Thy 1 , CD 34 and CD 45 ( B 220 ) , consistent with an origin very early in B lymphoid development . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
We have studied the expression of several leukocyte surface markers ( CD 2 , CD 3 , CD 4 , CD 8 , CD 7 , CD 26 , CD 25 , CD 14 , CD 18 , kCD 20 , CD 43 , CD 45 , CD45R , CD 71 and HLA class 1 and 2 ) and we find no differences in their expression between PPL . 1 and its parental Jurkat cell line . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
However , costimulation with CD45RA mAb completely reversed the hyporesponsiveness , suggesting that CD 45 controlled the CD 4 mediated hyporesponsiveness . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Since CD 45 is essential for T cell receptor ( TCR ) and CD 2 mediated activation of protein tyrosine kinases , we study here CD 45 associated tyrosine phosphatase activity in resting and activated CD 4 T cells from HIV infected patients . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Signal transduction and glycophosphatidylinositol linked proteins ( lyn , lck , CD 4 , CD 45 , G proteins , and CD 55 ) selectively localize in Triton insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes . ^^^ In the present study , we observed lck , lyn , src , hck , CD 4 , CD 45 , G proteins , and CD 55 ( decay accelerating factor ) expression in the buoyant low density Triton insoluble ( LDTI ) fraction of selected leukemic cell lines and granulocytes . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
There are several significant changes in the expression levels of alpha 4 and alphaM290beta7 integrins , CD11a , ICAM 1 , CD45RB , CD 4 , CD 44 , and CD 45 in different lymphocyte populations . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Cryostat sections were stained for lymphocyte subtypes ( CD 3 , CD 4 , CD 8 ) , macrophages ( CD 68 ) , common leucocyte antigen ( CD 45 ) , and Ki 67 , using a three stage immunoperoxidase reaction . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Immunohistochemical staining was performed on cryostat sections with monoclonal antibodies against : eosinophil cationic protein ( EG 1 , EG 2 ) , mast cell tryptase ( AA 1 ) , CD 45 , CD 22 , CD 3 , CD 4 , CD 8 , CD 25 , and CD45RO . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
From our results it may be concluded that there is no expression of the CD 4 antigen on the surface of human spermatozoa or on CD 45 ejaculate cells ( epithelial and germinal cells ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In dogs and cats , such cells were recently described ; they display a phenotype very similar to that of human LC ( CD 1 , CD 8 , CD11 / 18 , CD 45 and MHC 2 positive for canine LC , and CD 18 , CD 4 , panleukocyte antigen and MHC 2 positive for feline ones ) and in both species , Birbeck granules are observed . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In addition , phycoerythrin labeled CD 4 , CD 13 , and CD 14 antibodies were used to identify human lymphocytes , granulocytes , and monocytes ; CD 4 , GR 1 , and CD11b antibodies were used for mouse , and CD 45 , RP 3 , and ED 9 antibodies were used for identification of rat leukocyte subpopulations . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
They neo expressed CD1a , CD1b , CD1c , CD 80 , and CD 5 ; they massively up regulated CD 40 ( 109 fold ) and HLA DQ and DP ( 125 and 87 fold ) ; and significantly ( > 5 fold ) up regulated HLA DR , CD 4 , CD11b , CD11c , CD 43 , CD 45 , CD45R0 , CD 54 , CD 58 , and CD 59 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
A number of T cell surface transmembrane molecules such as CD 2 , CD 4 , CD 8 , lymphocyte functional antigen ( LFA ) 1 and CD 45 are known to interact functionally with the T cell receptor ( TCR ) complex during T cell activation . ^^^ Two types of large complexes containing protein tyrosine kinases were observed : the first one contained CD 3 and the transmembrane proteins CD 2 , CD 4 , CD 5 , CD 6 , CD 7 , CD 8 , CD11a , CD 38 , CD 43 , CD 45 , CD 71 , CD 98 and CD 99 and the other contained mainly the GPI anchored proteins CD 48 , CD 55 , CD 59 and CDw 108 as well as a fraction of CD 4 and CD 8 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Percentages of the different lymphocytes subsets , including CD 2 ( T cells ) , CD 4 , CD 45 RA ( suppressor inducer / virgin T cells ) , CD 4 , CD 29 , CD 8 , CD 19 ( B cells ) , as well as interleukin 2 ( IL 2 ) receptor ( CD 25 ) and class 2 antigen ( human leukocyte antigen HLA DR ) expression , were analyzed by flow cytometry . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Evidence for down regulation of highly expressed TCR by CD 4 and CD 45 on non selected CD4+CD8+ thymocytes . ^^^ However , such TCR suppression was not observed in positively selected DP cells and in the non selected DP cells obtained from CD 45 deficient mice or from mice receiving anti CD 4 mAb . ^^^ These findings suggest that the once highly expressed TCR at the DP stage is suppressed by CD 45 and / or CD 4 on non selected thymocytes . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
We have used this method to generate functional sFv to human CD 2 , CD 3 , CD 4 , CD 8 , CD 28 , CD 40 , CD 45 and to murine CD 3 and gp 39 , from hybridomas producing murine , rat , or hamster antibodies . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The aims of this study were to measure the immunosuppressive ability of castanospermine ( CAST ) in a rat heart allograft model , to measure its effect on membrane expression of adhesion molecules ( LFA 1 alpha , LFA 1 beta , ICAM 1 ) , class 1 and class 2 MHC antigens and on other T cell associated molecules ( CD 4 , CD 8 , CD 39 , CD 45 , W3 / 13 ) , to test its tolerogenic potential and its toxicity . ^^^ ICAM 1 expression on endothelial cells of the allograft vasculature , class 1 and class 2 MHC expression on lymphoid cells in the thymus , class 2 MHC expression on lymphoid cells in the allograft ; and CD 4 , CD 8 , CD 45 and W3 / 13 expression on lymphoid cells in some organs . ^^^ By contrast , in non grafted rats CAST significantly upregulated expression of class 1 MHC and CD 45 in the thymus , lymph node and spleen , ICAM 1 and CD 4 on lymphoid cells in the spleen , but reduced expression of LFA 1 alpha on lymphoid cells in the thymus . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Chimeric proteins in which the CD 2 transmembrane and / or cytoplasmic domains were deleted or exchanged with analogous regions of CD 4 , CD 28 or CD 58 retained association with high levels of murine CD 45 phosphatase activity , suggesting that the CD 2 extracellular domain largely controls interaction with CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Finally , cross linking of CD 45 and CD 3 antigens led to the expansion of CD3+ thymocytes co expressing CD 4 and CD 8 , indicating that simultaneous engagement of CD 45 and CD 3 molecules can block CD1+ cells at the double positive ( CD3+CD4+CD8+ ) differentiation stage . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Assays for the specific surface antigens CD 45 , CD 2 , CD 4 , CD 8 , CD 1 , MHC class 2 , and N 1 were employed to develop immunophenotypic profiles within the gated lymphocyte clusters from each TIL and PBL suspension . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 4 T cells are phenotypically divided by the expression of high and low molecular weight isoforms of CD 45 , surface markers that are frequently used to identify `` naive ' ' ( CD45Rhigh ) and `` memory ' ' ( CD45Rlow ) subsets . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The capacity of histocompatible BMT recipients to generate new CD4+ T lymphocytes was determined by FACS analysis with antibodies to the two isoforms of CD 45 : CD45RA , which is expressed on newly generated CD 4 T lymphocytes , and CD45RO , which is expressed on antigen specific memory CD 4 T lymphocytes . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Immunological parameters were differential blood counts ( CD 14 , CD 45 ) , monocyte subpopulations ( CD 14 , CD 16 ) , lymphocyte subpopulations ( CD 3 , CD 4 , CD 8 , CD45RO , CD 19 , CD 16 , CD 56 , HLA DR ) and natural killer cells ( CD 3 , CD 16 , CD 56 ) , oxidative burst activity of neutrophils , and phagocytosis of neutrophils ( flow cytometry ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Whole blood samples were labelled with the nuclear dye LDS 751 and with antibodies to HLA DR or belonging to CD 2 , CD 3 , CD 4 , CD 7 , CD 8 , CD 10 , CD 13 , CD 14 , CD 19 , CD 20 , CD 29 , CD 33 , CD 45 , CD45RA , CD 56 , and CD62L ( TQ 1 ) that were directly conjugated to either phycoerythrin ( PE ) and / or fluorescein isothiocyanate ( FITC ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The levels of expression of the CD 2 , CD 3 , CD 4 and CD 28 antigens were similar ; however , CD 45 and CD45RA antigen expression were slightly lower in cord cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In this report we describe a DP thymocyte population that associates positive selection with expression of high levels of CD 45 , CD 4 and CD 8 . ^^^ Thus , CD 45 increases the efficacy of positive selection of CD 4 CD8+ thymocytes that express H Y TCR . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Peripheral blood ( MOAb for immunophenotyping of lymphocytes : CD 14 , CD 45 , CD 3 , CD 19 , CD 4 , CD 8 , CD16 / 56 , HLA DR , CD 38 , CD 25 ) is the material of choice for detection and monitoring of immunodeficiences . ^^^ BAL ( MOAb for immunophenotyping of lymphocytes : CD 14 , CD 45 , CD 3 , CD 19 , CD 4 , CD 8 , CD16 / 56 , HLA DR ) is used mainly for differential diagnosis of extrinsic allergic alveolitis ( low CD4 / CD8 ratio ) and sarcoidosis ( high CD4 / CD8 ratio ) . ^^^ Extravascular fluids , suspension of single cells and BAL are preferred materials for detection and classification of non Hodgkin lymphomas ( MOAb for immunophenotyping of lymphocytes : CD 14 , CD 45 , CD 3 , CD 19 , CD 4 , CD 8 , CD16 / 56 , HLA DR , CD 38 , CD 25 , CD 23 , CD 5 , CDl1c , CD 30 , light chain immunoglobulins ) . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
PMA inhibited cell growth and decreased the amounts of CD1a and CD 4 while CD 3 , CD 8 , CD 25 , CD 45 , CD 57 and MHCI increased it ; the p 53 anti oncogene increased while actin levels remained constant . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Induction of association was not mediated by inside out signaling via the CD 4 associated tyrosine kinase p58lck , since it was not inhibited by the tyrosine kinase inhibitors herbymicin and genistein , nor by CD 45 bridging between CD 4 and the associating molecule , since similar patterns of association were detected IN cells expressing different CD 45 isoform patterns . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
To investigate the molecular bases for the dichotomies between naive and memory CD 4 T cells and to understand how the T cell receptor ( TCR ) directs diverse functional outcomes , we investigated proximal signaling events triggered through the TCR / CD3 complex in naive and memory CD 4 T cell subsets isolated on the basis of CD 45 isoform expression . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Naive and memory CD 4 T cells are frequently defined by exon specific monoclonal antibodies ( mAb ) which stain ( or not ) high or low molecular weight ( MW ) isoforms of the leucocyte common antigen CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Monoclonal antibodies ( MCAB ) against antigens CD 1 , CD 2 , CD 3 , CD 4 , CD 8 , CD 10 , CD 19 , CD 20 , CD 30 , CD 45 , CD 56 , BLA 36 were used for differentiating lymphoid cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
We also established that susceptibility to CD 45 mediated death is acquired during the transition of early CD 4 CD 8 TCR T cell precursors into CD4+ CD8+ TCR thymocytes and is increased with further acquisition of surface TCR on these cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
METHODS : We have assessed interstitial and glomerular leucocytes by avidin biotin peroxidase with monoclonal antibodies ( MA ) against leucocytes ( CD 45 ) , beta 2 integrin ( CD 18 ) , monocyte macrophages ( CD 14 ) , T ( CD 3 ) and T cell subsets ( CD 4 , CD 8 ) , and intercellular adhesion molecule 1 ( ICAM 1 ) ( CD 54 ) , and analysed their relation with the abnormal expression of ICAM 1 on proximal tubule epithelium in sequential renal sections from 48 patients with IgAN stratified according to the severity of the interstitial cellular infiltration observed by light microscopy . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Alternative methods used MAB against CD 45 ( FITC and PerCP labeled ) and CD 14 ( PE labeled ) or lymphocyte subsets such as CD 3 ( FITC labeled ) and CD 19 , CD 4 , CD 8 , CD 16 and CD 56 ( PE labeled ) in combination with CD 45 ( PerCP labeled ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Using locus specific probes for CD 2 , CD 4 , CD8alpha , CD 19 , CD 45 , and lambda 5 genes , we show that transcriptionally inactive but not transcriptionally active genes associate with Ikaros heterochromatin foci . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Specimens were snap frozen and immunohistochemical staining was performed on cryostat sections with monoclonal antibodies against : ( secreted ) eosinophil cationic protein ( EG 1 , EG 2 ) , mast cell tryptase ( AA 1 ) , CD 45 , CD 22 , CD 4 , CD 8 , CD 25 , and CD45RO . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Tricolor CD 45 was used to improve `` lymphogating . ' ' Fluorescein isothiocyanate or phycoerythrin conjugated monoclonal antibodies with specificity for CD 3 , CD 4 , CD 8 , and CD 20 ( lymphocyte subpopulations ) , for CD 69 ( activated lymphocytes ) , and for CD16 / 56 ( natural killer cells ) were used . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Here , we summarize the evidence supporting a critical role for the co receptor molecule ( CD 4 or CD 8 ) and CD 45 in determining the pattern of T cell receptor mediated signaling . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
We report 3 patients with crescentic MG who showed strong glomerular and interstitial infiltration of leukocytes ( CD 45 ) , T lymphocytes ( CD 3 ) , helper / inducer T cells ( CD 4 ) , cytotoxic / suppressor T cells ( CD 8 ) , and monocyte macrophages ( CD 14 ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Inhibition of HIV 1 replication by a monoclonal antibody directed toward the complementarity determining region 3 like domain of CD 4 in CD 45 expressing and CD 45 deficient cells . ^^^ Since CD 45 is the major protein tyrosine phosphatase associated to the plasma membrane in T cells , and has been shown to regulate the activity of several PTK , we postulated that CD 45 may be necessary for the inhibitory action of the CDR 3 like specific anti CD 4 antibodies . ^^^ Therefore we tested the effect of one such anti CD 4 monoclonal antibody , 13B8 . 2 , in repressing HIV replication in CD 45 positive cell lines and CD 45 deficient variants . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Both , the sphingomyelin cycle products and inhibitor of ceramide synthase fumonisin B 1 have been shown to affect the CD 3 , CD 4 , CD 8 , CD 45 , and other T lymphocyte surface antigen expression , to disrupt lymphocyte subpopulation balance , to inhibit DNA synthesis in normal lymphocytes , and to suppress an immune response to T dependent antigens in vivo . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
These cells expressed class 1 and class 2 MHC , CD1a , CD 2 , CD 4 , CD11c , CD 40 , CD 45 , CD 80 , CD 83 , and CD 86 and were potent stimulators of allogeneic T cell activation . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Signalling initiated with CD 4 TCR or TCR TCR interactions : comparison of tyrosine phosphorylation patterns and CD 45 effects . ^^^ In contrast to some earlier reports , we found that both the patterns of induced tyrosine phosphorylation and the effects of CD 45 modulation were essentially similar in the CD 4 TCR and the TCR TCR signal transduction cascades . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In six patients , further testing of CD 4 cells was done to determine whether they were newly formed , recent thymic emigrants ( CD 4 , CD 45 , and RA+ ) , or older educated lymphocytes ( CD 4 , CD 45 , and RO+ ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Leukocyte membrane antigens ( CD 3 , CD 4 , CD 8 , CD 14 , CD 16 , CD 19 , CD 45 , CD45RO , and CD 56 ) of endurance athletes were immunophenotyped ( dual color flow cytometry ) and list mode data analyzed by a self learning classification system in a state of an overtraining syndrome ( OT ; N = 15 ) and several occasions without symptoms of staleness ( NS ; N = 70 ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Our results demonstrate for the first time an altered association of p56lck with coreceptors such as CD 4 and CD 45 in the elderly . ^^^ These results suggest that alterations in p56lck tyrosine kinase and its association with CD 4 and CD 45 may underlie lowered T cell function during aging . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The down modulation of CD 4 induced by the GM 1 ganglioside is regulated by phosphatases and kinases : evidence from enzyme inhibitors and anti CD 45 antibodies . ^^^ Exposure to monoclonal antibodies ( mAbs ) against CD 45 and CD45RA but not against CD45RO abrogated the down modulation of CD 4 by GM 1 . ^^^ The present study indicates that the capacity of GM 1 to down modulate CD 4 depended on the CD 45 and particularly CD45RA molecules , while other gangliosides may utilize different cell surface structures to down modulate the expression of CD4 . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
METHODS : We assessed interstitial and glomerular leukocytes using an avidin biotin peroxidase method with monoclonal antibodies ( MAbs ) against leukocytes ( CD 45 ) , beta 2 integrin ( CD 18 ) , macrophages ( CD 14 ) , T cells ( CD 3 ) and T cell subsets ( CD 4 , CD 8 ) , intercellular adhesion molecule 1 ( ICAM 1 ) ( CD 54 ) , and HLA class 2 antigens . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
An hemagglutination assay according to standard procedures was performed along with the flow cytofluorometric analysis of leukocyte surface antigens CD 4 , CD 8 and CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The biopsy specimen showed angiocentric infiltrates of small to medium sized cells positive for CD 4 , CD 45 , and CD 56 but negative for CD 2 , surface and cytoplasmic CD 3 , CD 8 , CD 20 , and CD 57 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
We studied by simple and double immunolabeling techniques on tissue sections of normal human skin the phenotype of these cells and found them to express vimentin and Te 7 but none of the remaining markers sought ( factor XIIIa , von Willebrand factor , CD1a , CD 3 , CD 4 , CD 8 , CD 14 , CD 25 , CD 36 , CD 45 , CD 54 , CD 56 , LFA 1 , EGF R , S 100 protein , Mac 387 , and muscle specific actin ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Impaired CD 45 associated tyrosine phosphatase activity during HIV 1 infection : implications for CD 3 and CD 4 receptor signalling . ^^^ Proper function of the protein tyrosine phosphatase CD 45 is required for the positive regulation of the activity of src tyrosine kinases p56lck and p59fyn which participate in T cell receptor and CD 4 receptor signalling . ^^^ In this study , the effect of HIV 1 infection on the function of CD 45 associated tyrosine phosphatase activity in the H 9 T cell line has been investigated with respect to CD 3 and CD 4 ligation . ^^^ A significant reduction in CD 45 associated phosphatase activity was observed following CD 3 + CD 4 ligation in virally infected cells , whereas CD 45 activity was not compromised following CD 3 receptor ligation . ^^^ Dysfunctional CD 45 activity in infected cells was not attributable to reduced receptor surface expression induced by HIV 1 , since CD 4 , CD 3 and CD 45 expression levels were found to be intact . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Immunostaining ( APAAP method ) was performed on frozen cryostat sections with a panel of monoclonal antibodies to total leucocytes ( CD 45 ) , T lymphocyte phenotypic markers ( CD 3 , CD 4 , CD 8 ) , macrophages ( CD 68 ) , eosinophils ( EG 2 ) , and neutrophils ( elastase ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
A central role for lck activity in determining the threshold for differentiation of the CD 4 lineage is revealed in experiments with thymi deficient for a regulator of lck activity , CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
At different times after reconstitution , enriched CD 4 and CD 45 positive porcine cells were isolated from various mouse organs and tested for the presence of porcine NIPC by porcine IFN alpha specific ELISPOT assay , after in vitro stimulation by UV inactivated transmissible gastroenteritis virus ( TGEV ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Distribution of alloreactivity amongst the CD 45 isoforms of circulating CD 4 and CD 8 T lymphocytes . ^^^ Following isolation of CD 4 and CD 8 cells with immunomagnetic beads , CD 45 subsets were separated by negative depletion using specific monoclonal antibodies . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Apoptosis did not occur after secondary signaling through some other receptors ( CD 26 , CD 4 , CD 45 , and HLA class 1 ) or in HIV exposed resting CD8+ lymphocytes signaled through the homing receptors . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Resting T cells treated with sub lethal levels of BPD MA and light did not exhibit changes in surface levels of CD 3 , CD 4 , CD 8 , CD 28 , CD 45 or T cell receptor ( TCR ) beta chain structures . ^^^ Activated T cells treated with sub lethal levels of BPD MA and light exhibited lower CD 25 levels , a temporary block in cell cycle transition , but unaltered expression of MHC Class 1 , CD 3 , CD 4 , CD 8 , CD 45 , CD 54 , CD 71 , CD 122 ( IL 2R beta chain ) or TCR beta chain antigens 24 h afterward . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Dark blue cells expressing CD 38 , CD 45 , HLA DR , CD 4 , CD11a , CD 29 , CD49d , CD 50 , and CD 54 represented 0 . 30 ( 0 . 21 ) per cent of the mononuclear leucocytes ; most of these cells did not express T , B , NK , myelomonocytic , progenitor cell , proliferation , activation , blood dendritic cell , or follicular dendritic cell markers . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Also , the method of direct immunoluminescence using fluoroesceinisothiocymate labeled monoclonal antibodies against human antigens CD 4 , CD 8 , CD 25 and CD 45 was employed . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
For the analysis of lymphocyte subsets by two color flow cytometry , the monoclonal antibodies used were directed anti : CD 3 , CD 4 , CD 8 , CD 16 , CD 19 , D 25 , CD 45 , CD 56 and anti HLA DR . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Classification of the T cells based on their differential expression of CD 45 and CD 44 showed that the phenotypically different populations of CD 4 and CD 8 cells exhibited a type 1 cytokine pattern at latency and that reactivation of latent tuberculosis was associated with a shift in cytokines produced by these populations to a type 2 cytokine response . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The stimulation of macrophages through several different costimulatory molecules known to participate in macrophage lymphocyte interactions ( CD 4 , CD 40 , CD 45 , CD 86 , CD 95 [ Fas / Apo 1 ] ) also failed to improve mycobactericidal activity . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The results of our studies showed that in T cells , CD 45 AP is part of a multimolecular complex that includes not only CD 45 , but also TCR , the CD 4 and CD 8 coreceptors , and p 56 ( lck ) . ^^^ The association of CD 45 AP with TCR , CD 4 , and CD 8 seemed to occur via the shared ability of these molecules to bind CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 47 mediated cell death was independent of CD 3 , CD 4 , CD 45 , or p56lck involvement as demonstrated by studies with variant Jurkat cell lines deficient in these signaling pathways . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
We report that anti CD 3 triggered T lymphocyte proliferation was significantly decreased in T lymphocytes from elderly subjects , but the decrease was not due to an alteration of the percentage or mean fluorescence intensities of CD 3 , CD 4 , and CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
They expressed intermediate density CD 45 , as is characteristic of blasts ; in addition , the cells were positive for HLA DR , CD 2 , CD 4 , and the NK associated antigen CD 56 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Cell suspensions were stained with mAbs specific for CD 3 , CD 4 , CD 8 , CD 56 , CD 45 and CD 14 , and it was clearly shown that the developed method had no effect on surface glycoprotein expression . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Single and dual immunohistochemical staining in various combinations with monoclonal antibodies against CD 45 , CD 4 , CD 8 , major histocompatibility complex ( MHC ) class 2 , CD11c , NLDC 145 , and a variety of macrophage markers was performed . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 45 isoform phenotypes of human T cells : CD 4 ( + ) CD45RA ( ) RO ( + ) memory T cells re acquire CD45RA without losing CD45RO . ^^^ We conclude that CD 4 ( + ) CD45RA ( ) RO ( + ) T cells may re express CD 45 ( high ) isoforms but remain distinguishable from naive cells by their lower expression of CD45RA / RC and co expression of CD45RO . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Tissue activation of liver and kidney was assessed by staining of immediate early gene products ( IEG : FOS , JUN ) , and inflammatory markers ; cell adhesion molecules ( Intercellular adhesion molecule 1 , vascular cell adhesion molecule 1 ) , leukocyte infiltrates ( CD 45 , T cell receptor , CD 8 , CD 4 ) , and MHC class 2 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Peripheral airways were examined with histochemical methods to identify goblet cells and with immunohistochemical methods to identify total leukocytes ( CD 45 ( + ) cells ) , neutrophils , macrophages , CD 4 ( + ) and CD 8 ( + ) cells in the epithelium . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Pathology demonstrated demyelination in the CNS white matter with perivascular mononuclear cell infiltrates of CD 3 ( + ) CD 4 ( + ) CD 45 ( + ) lymphocytes with a subset CD 8 ( + ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
We transplanted human bronchi subcutaneously into mice with SCID , resected the xenografts after various incubation periods ( 7 174 d ) , and examined them for CD 3 ( + ) , CD 4 ( + ) , CD 8 ( + ) , and CD 45 ( + ) cells by immunohistochemistry . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Transformed and nontransformed cells expressing MHC class 1 , CD 5 , CD 3 , CD 4 , CD 6 , CD 7 , CD 34 , CD 45 , MHC class 2 , Fas ligand , and phosphatidylserine were assessed . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In contrast , sCR 1 treatment did not affect the number of graft infiltrating CD 4 ( + ) and CD 8 ( + ) T cells , CD 45 ( + ) B cells , ED 1 ( + ) and ED 3 ( + ) macrophages , or immune activation with expression of IL 2Ralpha or MHC class 2 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
These cells express the T cell antigens CD 2 and CD 5 on their surface , but not CD 7 , and they express CD 4 and CD 45 at numbers of molecules per cell typical for T lymphocytes . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Cryostat sections were stained with haematoxylin and eosin ( H & E ) for assessment of mucosal inflammation and morphometry , and for lymphocyte subtypes ( CD 3 , CD 4 , CD 8 ) , macrophages ( CD 68 ) , common leucocyte antigen ( CD 45 ) , and HLA DR , using a three stage immunoperoxidase reaction . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
BAL lymphocyte subsets were phenotyped by direct two and three color immunofluorescence ( applied DAKO A / S monoclonal antibodies : anti CD 3 , CD 4 , CD 8 , CD11b , CD 14 , CD 15 , CD 16 + 56 , CD 19 , CD 25 , CD 45 , HLA DR ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Results indicate that the percentages of Class 1 , Class 2 , CD 3 , CD 8 , CD 4 , CD 45 , monocyte , gamma delta T cell populations , and total number of granulocytes identified using this method were comparable to standard values or to values obtained following separation of white blood cells from red blood cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Here we demonstrate that the defective LN development in TRANCE ( / ) mice correlates with a significant reduction in lymphotoxin ( LT ) alphabeta ( + ) alpha ( 4 ) beta ( 7 ) ( + ) CD 45 ( + ) CD 4 ( + ) CD 3 ( ) cells and their failure to form clusters in rudimentary mesenteric LNs . ^^^ Transgenic TRANCE mediated restoration of LN development requires LTalphabeta expression on CD 45 ( + ) CD 4 ( + ) CD 3 ( ) cells , as LNs could not be induced in LTalpha ( / ) mice . ^^^ LTalpha ( / ) mice also showed defects in the fate of CD 45 ( + ) CD 4 ( + ) CD 3 ( ) cells similar to TRANCE ( / ) mice . ^^^ Thus , we propose that both TRANCE and LTalphabeta regulate the colonization and cluster formation by CD 45 ( + ) CD 4 ( + ) CD 3 ( ) cells in developing LNs , the degree of which appears to correlate with the state of LN organogenesis . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Leucocyte number and viability were essentially unchanged from freshly obtained blood , but the expression of cell surface lymphocyte activation antigens ( CD 3 , CD 4 , CD 28 , CD 2 , CD 45 ) decreased rapidly within the first 24 h and continued to fall to less than 20 % of original levels by d 9 of storage at 4 degrees C . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
A 72 year old Caucasian man presented with a malignant neoplasm comprised of blastoid cells without azurophilic granules in the Giemsa stain , with positivity for CD 2 , CD 4 , HLA DR , CD 45 and CD 56 , and negativity for CD 3 ( surface and cytoplasmic ) and CD 5 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Skin biopsies were taken at the same time points , fixed , sectioned , and stained with Giemsa for histologic evaluation , or with mouse anti swine monoclonal antibodies ( CD 1 , CD 2 , CD 4 , CD 5 , CD 8 , CD 25 , CD 45 , MHCII ) and with one mouse anti human monoclonal antibody ( CD62E ) cross reacting with swine for immunohistochemical evaluation . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Reconstitution of the T cell compartment was monitored by determining the expression of CD 45 isoforms by developing CD 4 ( + ) cells in the peripheral blood and in discriminating expanded ( CD45RO ( + ) ) and newly generated ( CD45RA ( + ) ) T cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Ten UCB and 10 PB specimens were kept up to 48 hr and then placed in CC for 1 week , with removal of aliquots for staining with CD 3 , CD 4 , CD 8 , CD 19 , and CD 45 at intervals . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In EBV seropositive individuals , the phenotype of the EBV specific cytokine producing T cells was evaluated using four color flow cytometry and found to be CD 45 ( + ) , CD 3 ( + ) , CD 4 ( + ) , CD45RA ( ) , CD 69 ( + ) , CD 25 ( ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Analyses of the lymphocyte subpopulations of two time points resulted in a strong correlation with high statistical significance for the percentage of CD 3 , CD 4 , CD 8 , CD 19 , CD 45 subtypes and CD56 / 16 positive cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Expression of some leukocyte antigens ( including CD 45 ) and its isoforms ( CD 2 , CD 4 , CD 5 , CD 6 , CD 7 , and CD 8 ) was examined in the human periapical granulation tissue samples in the present study . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Cellular immunity included cytometric studies of CD 3 , CD 4 , CD 8 , CD16 / CD56 , CD 19 , CD 20 , 23 , CD 3 HLA DR+ , CD 45 RA , CD 45 RO , alpha / beta and gamma / delta T cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In the present study , we found that , in resting lymphocytes , an enzymatically active fraction of CD 45 molecules is associated to the CD 4 coreceptor . ^^^ TCR engagement by an agonist ligand markedly inhibited this pool of CD 45 phosphatase without affecting the CD 4 / CD 45 association . ^^^ These results reveal that the modulation of the CD 4 associated CD 45 phosphatase activity is a very early biochemical event triggered by TCR stimulation . ^^^ Since the recruitment of CD 4 is an initial step in the activation process , the inhibition of this pool of CD 45 molecules would be crucial to prevent dephosphorylation of relevant substrates which promote the activation process . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Peripheral blood mononuclear cells ( PBMC ) from 251 HIV positive drug abusers of known clinical stage and from 40 healthy donors were tested for conventional immunologic markers ( CD 3 , CD 4 , CD 8 , CD 19 , CD 14 , CD16 / CD56 , CD 45 and HLA DR ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 99 mediated death signaling proceeded independently of functional CD 3 , CD 4 , CD 45 , and p 56 ( lck ) , revealed distinctions from CD 47 mediated T cell death responses , and was not influenced by interference with CD 47 signaling . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The following panel of monoclonal antibodies were used as parameters : CD 1a ( Langerhans cells ) , CD 4 ( T helper cells ) , CD 8 ( T suppressor cells ) , CD 11c ( monocytes and macrophages ) , CD 45 RO ( memory cells ) , CD 45 RA ( naive cells ) , eosinophil cationic proteins ( ECP ) , neutrophil elastase , and HLA DR . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
After transfer into newborn mice , the IL 7Ralpha ( + ) Sca 1 ( low ) c Kit ( low ) population rapidly differentiated into CD 45 ( + ) CD 4 ( + ) CD 3 ( ) cells , which are candidate cells for initiating lymph node and Peyer ' s patch formation . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The findings indicate that at least for CD 4 ( + ) T cells , where CD 45 isoform expression is related to functional memory , these two cytokines are produced predominantly by cells with a memory phenotype . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Flow cytometric analysis of adult stem cell populations revealed positive staining for CD 34 and CD 90 and negative staining for CD 3 , CD 4 , CD 8 , CD11c , CD 33 , CD 36 , CD 38 , CD 45 , CD 117 , Glycophorin A , and HLA DR II . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
TcR alpha / beta ( + ) CD 4 ( ) CD 8 ( ) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD 45 isoform that is analogous to murine B 220 and represents a marker of altered O glycan biosynthesis . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The analysis of T cell subsets was performed with a flow cytometry method and with the following antibodies : anti CD 3 , CD 4 , CD 8 , CD 16 , CD 25 , CD 45 , CD 56 , and HLA DR . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
MAb to antigens CD 25 , CD 8 , CDw 50 , CD 5 , CD 4 , CD 7 , CD 3 , CD 71 , CD 34 , CD 45 , CD 38 , CD11b , CD 16 , and CD 95 have gained worldwide recognition at International HDLA Workshop Conferences . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Results of immunophenotypic analysis of the lymphoma cells by immunocytochemistry or flow cytometry were positive for CD 19 , CD 20 , CD 22 , CD 45 , and HLA DR but negative for CD45RO , CD 3 , CD 4 , and CD 8 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
A T cell line generated in this way ( called TM PTR 4 ) had a CD 3 ( + ) , CD 5 ( + ) , CD 4 ( ) , CD 8 ( + ) , CD 45 ( Ro+ ) , CD 56 ( ) immunophenotype and a HLA A2 . 1 restricted cytotoxic activity to PTR 4 peptide pulsed CIR A 2 ( HLA A2 . 1 ( + ) ) target cells , PTH rP ( + ) / HLA A2 . 1 ( + ) CIR A 2 transfected with PTH rP gene , prostate carcinoma LNCaP cells , and autologous metastatic prostate cancer cells ( M CaP ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The CD 28 ( ) CD 4 ( + ) T cells did not express detectable levels of CD 25 , CD 69 , 5 ( alpha ) 24 , or CTLA 4 but expressed heterogeneous amounts of CD 45 RA on the surface . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Monocytes and lymphocytes of 30 patients with acute hearing loss were determined by flow cytometry before , throughout and after HBO therapy using monoclonal antibodies to CD 3 , CD 4 , CD 8 , CD 14 , CD 25 , CD 45 and HLA DR . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The combination of all four agonists significantly induced expression of CD 45 RO ( fresh p < 0 . 05 , and thawed p < 0 . 001 ) in both the CD 4 ( + ) and CD 8 ( + ) T cells expressing CD 25 ( fresh UCB p < 0 . 01 [ CD 4 ] and p < 0 . 005 [ CD 8 ] , respectively ; thawed UCB p < 0 . 001 [ CD 4 ] and p < 0 . 001 [ CD 8 ] ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
IL 5 ( / ) OVA sensitized mice had significantly higher nasal mucosal CD 4 ( + ) cells and basophilic cell counts as well as nasal symptoms and histamine hyperresponsiveness than the nonsensitized group ; however , there was no eosinophilia in either nasal mucosa or bone marrow ; significantly lower numbers of eosinophil / basophil CFU and maturing CFU eosinophils in the presence of recombinant mouse IL 5 in vitro ; and significantly lower expression of IL 5Ralpha on bone marrow CD 34 ( + ) CD 45 ( + ) progenitor cells in IL 5 ( / ) mice . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
These results underscore the importance of NFAT in HIV 1 regulation and for the first time identify the role of the CD 45 isoform in limiting productive HIV 1 replication to the human CD 4 memory T cell subset . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
We examined the CD 45 isoforms expressed in the various human thymocytes ' subsets defined by CD 3 , CD 4 , and CD 8 expressions using RT PCR and 4 color flow cytometry . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The cross linking of HIV on permissive cells results aggregation of HIV particles with surface nucleolin , CD 4 , and CXCR 4 , but without affecting the organization of CD 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
His tumor showed extensive coagulative necrosis with angioinvasion by large lymphoma cells expressing CD 2 , CD 8 , CD 16 , CD 43 , CD 45 , CD45RO , CD 56 , T cell intracellular antigen 1 , and granzyme B , but not CD 3 , CD 4 , CD 20 , CD 57 , CD 68 , and betaF 1 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
METHODS : Double immunofluorescence and serial immunoenzymatic studies were performed on normal , osteoarthritic , and RA synovium and tonsil with antibodies to CD 163 , CD 45 , CD 68 , CD 14 , CD 3 , CD 4 , CD 8 , CD 19 , and IFNgamma . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Since there is evidence that CD 22 binds preferably to CD 45 , even though many cell surface proteins carry alpha 2 6 linked sialic acid , we compared the affinities of CD 22 binding to CD 45 , to CD 4 carrying alpha 2 6 linked sialic acid , and to a synthetic alpha 2 6 sialoglycoconjugate . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
When coupled with quality control for WCC on hematology analyzers , the DP method with CD 45 PanLeucogating represents a robust CD 4 T cell assay that is as accurate as the SP volumetric technique . ^^^ This DP method uses only two , CD 45 and CD 4 , antibody reagents and can be run on any pair of hematological analyzer plus flow cytometer . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Following immunofluorescent staining , three color flow cytometry analysis identified LPLs on the basis of CD 45 side scatter gating , which in turn , were further subdivided into CD 4 ( + ) , CD 8 ( + ) , and CD 19 ( + ) cells to account for the predominant T and B cells in the lamina propria . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Initiation of NALT organogenesis is independent of the IL 7R , LTbetaR , and NIK signaling pathways but requires the Id 2 gene and CD 3 ( ) CD 4 ( + ) CD 45 ( + ) cells . ^^^ NALT organogenesis is initiated following the adoptive transfer of CD 3 ( ) CD 4 ( + ) CD 45 ( + ) cells into Id 2 ( / ) mice , constituting direct evidence that CD 3 ( ) CD 4 ( + ) CD 45 ( + ) inducer cells can provide an IL 7R , LTalpha1beta2 / LTbetaR , and NIK independent tissue organogenesis pathway for secondary lymphoid tissue development . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
A discrete population of CD 45 double intermediate RA ( + ) / RO ( + ) CD 4 ( + ) cells was also preferentially expanded in the IL 2 group , and the number of these cells strongly correlated with the total CD 4 ( + ) count . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Affordable CD 4 ( + ) T cell counting by flow cytometry : CD 45 gating for volumetric analysis . ^^^ Thus , on the basis of the high efficiency and excellent agreement with the present industry standards , volumetric flow cytometers with automated gating protocols and autobiosamplers , complemented by generic CD 45 , CD 4 , and CD 8 MAbs used in two color immunofluorescence , represent the most suitable arrangements for large regional laboratories in resource poor settings . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The 3A9H cells expressing Lck CD 45 were reduced in their responses to HEL or co cross linking of CD 3 and CD 4 , as assessed by IL 2 production and Ca ( 2+ ) mobilization . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The peripheral blood T cell subsets including CD 3 ( + ) , CD 4 ( + ) , CD 8 ( + ) , NK , CD 4 ( + ) / CD8 ( + ) ratio , CD 4 ( + ) CD 45 ( + ) , CD 4 ( + ) CD 29 ( + ) , CD 8 ( + ) CD 28 ( + ) and CD 8 ( + ) CD 28 were measured by flow cytometry in both groups before and one week after treatment . ^^^ After TACE , no significant changes occurred in CD 3 ( + ) , CD 4 ( + ) , CD 8 ( + ) , NK , CD 4 ( + ) / CD8 ( + ) , CD 4 ( + ) CD 29 ( + ) or CD 8 ( + ) CD 28 cells in group A , while significant decrease in CD 4 ( + ) CD 45 ( + ) and increase in CD 8 ( + ) CD 28 ( + ) cells were observed ( P < 0 . 05 and P < 0 . 001 , respectively ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The expression of CD 45 , CD 5 , CD 3 , and CD 4 followed a circadian rhythm . ^^^ Their acrophases suggested temporal association between CD 45 and CD 5 at the end of the active phase and between CD 4 and CD 3 at the beginning of this phase . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The expression of CD 45 isoforms on the surface of human T cells has been used to classify CD 4 ( + ) T lymphocytes into nave cells ( CD45RA+ ) and memory T cells ( CD45RO+ ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
PI 9 is evident in thymic DCs ( CD 3 ( ) , CD 4 ( + ) , CD 8 ( ) , CD 45 ( + ) ) , tonsillar DCs , and DC subsets purified from peripheral blood ( CD 16 ( + ) monocytes and CD 123 ( + ) plasmacytoid DCs ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Cell surface receptors ( CD 4 , CD 8 , CD 3 , CD 14 , CD 45 , CD56+16 , and HLA DR ) were detected by flow cytometry using monoclonal antibodies tagged with fluorescent markers and serum levels of C reactive protein ( CRP ) were measured . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
It was observed that the MLO Y 4 osteocyte like cells express CD 40 antigen and MHC class 1 antigen , but they are negative for a series of other dendritic cells markers ( DEC 205 , CD11b , CD11c , CD 86 , and MHC class 2 ) and immune cell markers [ CD 45 , CD 3 , CD 4 , B 220 , Gr 1 , and CD 40 ligand ( CD40L ) ] . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
At diagnosis , five year nonsurvivors showed increased patient age and higher concentration of cells in the analyzed specimen , as well as increased levels of % CD 2 , CD 4 , CD 13 , CD 36 , and CD 45 positive AML blasts . ^^^ Two year nonsurvivors were characterized by a data pattern of increased patient age and levels of % CD 4 , CD 7 , CD11b , CD 24 , CD 45 , TH 126 , and HLA DR positive AML blasts and decreased levels of % CD 1 , CD 65 , CD 95 , and TC 25 positive AML blasts . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The effect of purified glycosphingolipids from Leishmania ( Leishmania ) amazonensis on human lymphoproliferation , on expression of human lymphocyte and monocyte markers ( CD 3 , CD 4 , CD 8 , CD 14 , CD 19 , and CD 45 ) , and on lymphocyte protein kinase C activity was analyzed . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
We used this assay to demonstrate that exposure of Jurkat T cells , and primary CD 4 ( + ) T cells to H ( 2 ) O ( 2 ) decreases the specific activity of their CD 45 , mimicking the changes seen in some diseases . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Changes in leukocyte subpopulations in the blood of the calves were detected both with routine haematological methods and by FCM using specific monoclonal antibodies directed against CD 14 , CD 45 , CD 2 , CD 4 , CD 8 and WC 4 ( a specific surface marker for bovine B lymphocytes ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
By selecting the CD 45 ( + ) population and simultaneous staining with several leukocyte lineage markers ( CD 3 , CD 4 , CD 8 , CD 56 , and CD 19 ) , MHC mismatched leukocytes were consistently detected in cell suspensions prepared from directly stained whole blood samples with a threshold sensitivity as low as 0 . 1 % 0 . 2 % . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Medians ( range ) of positive cells were for CD 3 : 20 . 5 ( 0 530 . 0 ) , CD 4 : 6 . 2 ( 0 124 . 4 ) , CD 8 : 1 . 8 ( 0 81 . 5 ) , CD 25 : 0 ( 0 62 . 3 ) , HLA DR : 80 . 0 ( 3 . 5 524 . 2 ) , EG 1 : 5 . 3 ( 0 180 . 6 ) , EG 2 : 6 . 4 ( 0 48 . 8 ) , AA 1 : 51 . 3 ( 0 286 . 4 ) , CD 45 : 39 . 7 ( 0 448 . 5 ) and CD45ro : 28 . 6 ( 0 425 . 2 ) . ^^^ The presence of an animal at home was associated with lower positive cell counts for CD 4 ( p = 0 . 02 ) , CD 45 ( p = 0 . 02 ) and HLA DR ( p = 0 . 01 ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Following in vivo labeling of dividing cells with 6 , 6 D ( 2 ) glucose in eight healthy volunteers , peripheral blood T cells were sorted by CD 4 , CD 8 and CD 45 phenotype . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
More severe graft injury after the onset of rejection in untreated allograft recipients was accompanied by a higher number of graft infiltrating CD 45 ( + ) cells , but similar proportions of CD 4 ( + ) and CD 8 ( + ) cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
To investigate the dynamics of clonal expansion , we measured cell proliferation during AIM using deuterated glucose to label DNA of dividing cells in vivo , analyzing cells according to CD 4 , CD 8 and CD 45 phenotype . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The immunoprofile of the cells was positive for CD 45 , HLA DR , CD 30 and negative for EMA , CD 34 , CD 38 , CD 2 , CD 3 , CD 4 , CD 7 , CD 8 , CD 10 , CD 15 , CD 19 and CD 20 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Formalin fixed , paraffin embedded tissues were stained with antibodies against lymphocytes ( CD 45 , CD 3 , CD 4 , CD 8 , CD 20 ) , macrophages ( CD 68 ) including dendritic cells ( S 100 ) , markers for lymphocyte activation ( CD 30 , HLA DR ) , natural killer cells ( CD 56 and CD 57 ) , beta 2 microglobulin and keratin . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 4 and CD 8 counts , CD 45 RO+ and RA+ subsets and signal joint T cell receptor excision circles ( sjTREC ) in peripheral blood mononuclear cells ( PBMCs ) were measured every 2 weeks . ^^^ There was no significant difference between the thymosin alpha 1 and control groups in CD 4 , CD 8 and CD 45 lymphocyte subset changes at week 12 ; however , PBMC sjTREC levels increased significantly in the thymosin alpha 1 treated patients compared to controls at week 12 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
For immunohistochemical characterization of the inflammatory reaction , four antibodies CD 4 , CD 8 , CD 45 and CD 68 were used . ^^^ No significant quantitative differences in the specific cellular infiltrates ( CD 4 , CD 8 , CD 45 , CD 68 ) were observed in the three different groups . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Immune cells carrying receptors CD 3 , CD 4 , CD3 / 4 , CD 8 , CD3 / 8 , CD 14 , CD 45 , CD14 / 45 , HLA DR , CD3 / HLA DR , CD16 / 56 , and CD3 / 16 / 56 by applying DAKO Dual Color Reagent , and non specific indicators of reactivity , were investigated in the peripheral venous blood samples . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
PLP may also interfere with the dimerization of CD 4 molecules , which occurs during T cell activation , or with the interaction of this dimer with other molecules on the T cell surface , such as CD 45 , thereby further rendering T cells anergic or driven to apoptosis . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Also , they induced a significant expansion of total T cells and of the helper and cytotoxic T cell lineages ( CD 45 ( + ) CD 3 ( + ) , CD 4 ( + ) CD 8 ( ) , CD 4 ( ) CD 8 ( + ) ) as well as a marked increase in the expression of the antigens of MhcI and MhcII on T cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
We assessed subjective sleep quality , pain , and cell mediated immune functions in RA patients with ( n = 20 ) and without ( n = 20 ) MD by using Pittsburgh Sleep Quality Index ( PSQI ) , visual analogue scale ( VAS ) , and fluorescein isothiocyanat ( FITC ) labeled CD 3 , CD 4 , CD 8 , CDI 9 , CD 45 , CD 56 , and HLADR T monoclonal antibodies by flow cytometry . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 4 T cells have been classified according to the expression of the CD 45 isoforms into ' naive like ' T cells ( CD45RA ) and ' memory like ' T cells ( CD45RO ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
These findings confirm the precision of FCM for BAL T cell subset ratio analysis and suggest that the optimal gating strategy may be a simple panel using only CD 45 , CD 4 and CD8 . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
RESULTS : HR 8348 cell line did not express CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , TCR , CD 10 , CD11b , CD 14 , CD 16 , CD 19 , CD 22 , CD 25 , CD 28 , SmIg , CD 33 , CD 35 , CD 36 , CD41a , CD 45 , CD45RA , CD45RO , CD 56 , CD 61 , CD 64 , CD66b , CD 69 , CD 71 , CD 117 , CD 122 and P glycoprotein but expressed CD 13 , CD 15 , CD 20 , CD 38 , CD 95 and HLA DR . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
RESULTS : The absolute numbers of peripheral blood lymphocytes and their subpopulations ( CD 45 , CD 3 , CD 4 , CD 8 ) were 1298 + / 785 , 897 + / 606 , 510 + / 372 , 362 + / 263 / mm ( 3 ) , respectively , significantly lower in SARS patients as compared to the normal controls ( 2024 + / 423 , 1391 + / 289 , 795 + / 129 , 551 + / 183 / mm ( 3 ) ) . ^^^ There were significant differences ( P < 0 . 01 ) for CD 45 , CD 3 , CD 4 , CD 8 , but with no significant difference ( P > 0 . 05 ) for CD4 / CD8 ratio between severe and mild , recovery and death groups . ^^^ The lymphocytes and their subpopulations ( CD 45 , CD 3 , CD 4 , CD 8 ) declined in the 1st week and to the lowest level ( 977 + / 579 , 641 + / 466 , 360 + / 275 , 270 + / 216 / mm ( 3 ) ) in the 2nd week . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Lymphocytes were isolated from the intestines with CD 45 ( + ) cells collected by positive selection using magnetic bead separation columns , and lymphocyte subpopulations were analyzed by flow cytometry for CD 45 ( + ) , CD3alphabeta ( + ) , CD3gammadelta ( + ) , CD8beta ( + ) , CD8alpha ( + ) , CD 4 ( + ) , and NK ( + ) phenotypic markers . ^^^ There was a significant effect of exercise condition on total intestinal CD 45 ( + ) leukocytes ( P < 0 . 01 ) and CD3alphabeta ( + ) ( P < 0 . 05 ) , CD8alpha ( + ) ( P < 0 . 001 ) , and CD 4 ( + ) ( P < 0 . 05 ) intestinal lymphocytes , with fewer cells at 24 h postexercise compared with the other treatment conditions . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
RESULTS : The bronchiolitis obliterans group showed marked neutrophilia , high IL 8 and higher CD 4 ( + ) CD 25 ( + ) and CD 8 ( + ) CD 45 ( + ) bronchoalveolar lavage fluid levels when compared with their stable controls . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
METHODS : In orbital tissue cryosections of patients with A TAO ( n = 15 ) , 1 TAO ( n = 11 ) , and healthy controls ( n = 14 ) , adipose and fibrovascular areas were evaluated for MHC 2 ( + ) cells , CD 45 ( + ) total leukocytes , myeloid cells ( CD 33 ( + ) monocytes ; CD 14 ( + ) macrophages ; mature RFD 7 ( + ) macrophages ; RFD 1 ( + ) dendritic cells ( DCs ) ) , and lymphoid cells ( CD 4 ( + ) T cells ; alphabeta and gammadelta T cells ; CD 20 ( + ) B cells ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In this study , CD 45 ( + ) cells isolated from immunologically quiescent murine retina were tested in vitro for functional evidence of Ag presentation to naive and Ag experienced CD 4 T cells specific for beta galactosidase . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
RESULTS : ( 1 ) mPEG nearly completely covered up the CD 4 and CD 8 antigens on T cells , while the number of CFU GM did not show any obvious change between the modified and non modified cell groups . ( 2 ) GVHD appeared later in the modified mononuclear cell group than in the non modified group , and the survival rate was elevated in the modified group than in the non modified group . ( 3 ) Humanized CD 45 cells were found in mouse ' s bone marrow at the 47th day after transplantation of both mPEG modified and non modified mononuclear cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
During murine embryogenesis , the formation of Peyer ' s patches ( PPs ) is initiated by CD 45 ( + ) CD 4 ( + ) CD 3 ( ) lymphoid tissue inducers that trigger adhesion molecule expression and specific chemokine production from an organizing stromal cell population through ligation of the lymphotoxin beta receptor . ^^^ This in turn encompasses CD 45 ( + ) CD 4 ( + ) CD 3 ( ) cells interspersed with ICAM 1 / VCAM 1 / mucosal addressin cell adhesion molecule 1 , lymphotoxin beta receptor positive , chemokine producing cells analogous to the organizing population previously observed in PPs . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Flow cytometry was done to investigate changes in immunophenotypes in endocervical secretions and peripheral blood using monoclonal antibodies for surface markers ( CD 3 , CD 4 , CD 8 , CD 19 , CD 45 and CD 83 ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
KIL depends on interleukin 7 for survival and proliferation and is NK1 . 1 ( + ) CD 3 ( ) TCRalphabeta ( ) TCRdeltagamma ( ) CD 4 ( ) CD 8 ( ) CD 19 ( ) CD 25 ( + ) CD 43 ( + ) CD 45 ( + ) CD49b ( ) CD 51 ( + ) CD 94 ( + ) NKG2D ( + ) Mac 1 ( / low ) B 220 ( ) c kit ( + ) perforin 1 ( + ) granzyme B ( + ) Notch 1 ( + ) , and cytotoxic . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
METHOD OF STUDY : Using reverse transcriptase polymerase chain reaction ( RT PCR ) , expression of IP 10 , IFN gamma , tumor necrosis factor alpha , interleukin 10 ( IL 10 ) , CXCR 3 mRNA and leukocyte cell surface markers , CD 4 , CD 8 , CD11b and CD 45 mRNA during the caprine early pregnancy was investigated . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Cross linking of CD 45 on aged CD 4 ( + ) CD 25 ( ) T cells was required for the disruption of their suppressive activity . ^^^ Our results demonstrate an unexpected function of CD 45 as a negative regulator neutralizing the suppressive activity of aged CD 4 ( + ) CD 25 ( ) and young CD 4 ( + ) CD 25 ( + ) T cells . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The combination of eight antibodies against CD 3 , CD 4 , CD 8 , CD 14 , CD 16 , CD 19 , CD 45 , and CD 56 was used to characterize NK and NKT cells and their subsets . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
We performed immunolabeling for FSP1 / S100A4 on thin cryostat sections of perfusion fixed rat and mouse kidneys with peritubular inflammation , induced by thiazides and glomerulonephritis , respectively , in combination with ecto 5 ' nucleotidase ( 5 ' NT ) , recognizing local cortical peritubular fibroblasts , with CD 45 , MHC class 2 , CD 3 , CD 4 and Thy 1 , recognizing mononuclear cells , with alpha smooth muscle actin ( alphaSMA ) , as marker for myofibroblasts , and vimentin for intracellular intermediate filaments in cells of mesenchymal origin . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Several galectin 1 receptors are discussed such as CD 45 , CD 7 , CD 43 , CD 2 , CD 3 , CD 4 , CD 107 , CEA , actin , extracellular matrix proteins such as laminin and fibronectin , glycosaminoglycans , integrins , a beta lactosamine glycolipid , GM 1 ganglioside , polypeptide HBGp 82 , glycoprotein 90 K / MAC 2BP , CA 125 cancer antigen , and pre B cell receptor . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Colitis was induced by transfer of CD 4 ( + ) T cell blasts to syngenic RAG 1 ( / ) mice or CD 45 RB ( high ) CD 4 ( + ) T cells to SCID mice . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The tumor cells expressed focal immunocytochemical reactivity to CD 45 and CD 68 , but were negative for CD 2 , CD 3 , CD 4 , CD 8 , CD 20 , CD 30 , CD45RO , epithelial membrane antigen ( EMA ) , cytokeratin , and HMB 45 . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Lymphocyte expression of CD 45 , CD 4 , CD 8 , CD 3 , CD 23 , CD 19 and CD 95 were determined by flow cytometry . ^^^ RESULTS : The levels of TNF alpha , IL 1alpha , and CD 4 , CD4 / CD8 , CD 45 , CD 19 , CD 23 and CD 95 positive lymphocytes were lower in MDR TB than in N TB patients ( P < 0 . 05 ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Flow cytometry was used to identify CD19+ ( B lymphocytes ) , CD2+ ( total T lymphocytes ) , CD 3 ( + ) CD4+ ( helper T cells ) , CD 3 ( + ) CD8+ ( suppressor / cytotoxic T lymphocytes ) , CD 4 ( + ) CD29+ and CD 4 ( + ) CD 45 ( ) RA+ ( helper / inducer subpopulation and naive Tlymphocytes ) in the acute and the convalescent phases of disease . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The virus induced the production of TNF alpha , IL 10 and IL 12 p 70 while inhibited IFN alpha secretion , increased the percentage of CD 2 ( + ) cells while decreased that of CD 4 ( + ) or CD 45 RA ( + ) cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
IL 4 secretion in allergic children to sensitizing allergens was mainly restricted to the CD 4 ( + ) CD 45 RO ( + ) population while in non atopic controls both CD 4 ( + ) and CD 8 ( + ) CD 45 RO ( + ) cells produced mostly IFN gamma . ^^^ CONCLUSION : Food allergic children ' s IL 4 cytokine response to their relevant allergens is predominantly from a memory population of CD 4 ( + ) CD 45 RO ( + ) cells , whereas IL 4 and IFN gamma secretion of non allergic controls was predominantly from mixed CD 4 ( + ) and CD 8 ( + ) CD 45 RO ( + ) populations . . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
There was no apparent difference between the two treated groups in phenotypic changes of CD 3 , CD 45 , CD 4 , or CD 8 positive cells from the spleen or mesenteric lymph nodes . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The immunohistochemical study of CD 4 , CD 8 and CD 45 lymphocytes , metalloproteinase MMP 9 and viral Tax protein in pathological samples of salivary glands may help to differentiate primary from viral Sicca syndrome . ^^^ Immunohistochemistry was performed using antibodies against CD 4 , CD 8 and CD 45 lymphocytes , metalloproteinase MMP 9 and viral Tax protein . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
METHODS : Two systems were simultaneously compared on 67 blood samples and external quality controls , using CD 3 , CD 4 , CD 8 , CD 19 , CD16 / 56 , and CD 45 in one tube TRUCOUNT beads ( BD Biosciences ) or two tubes ( TetraChrome and Flowcount , Beckman Coulter and DakoCytomation ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Blood samples were obtained at 7 , 14 and 21 days from both normal and clinically affected piglets for routine haematology and for the determination of CD 45 , CD 21 , CD 4 , CD 8 and gammadeltaTCR cell markers by flow cytometry . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Using immunochemistry on cytologic and histologic samples , the pleomorphic histiocytic cells were positive for CD1c , CD11ad , CD 45 , lysozyme , and vimentin , and were negative for CD 3 , CD 4 , CD79a , CD 90 , and pancytokeratin . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
To investigate the expression of HLA G on the surface of peripheral mononuclear ( PMNL ) cells , we have used monoclonal antibodies in flow cytometry to estimate CD 4 , CD 25 , CD 45 , and HLA G content . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Additional experiments established that induction of these immune mediators preceded the presence of CD 3 , CD 4 , CD 8 , and CD 45 mRNA in the brain , and immunohistochemical analysis confirmed the presence of infiltrating CD 3 ( + ) cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 4 and CD 8 T lymphocytes from transgenic ( Tg ) mice expressing single CD45RABC or CD45RO isoforms show increased apoptosis and the extent of apoptosis is inversely correlated with the level of CD 45 expression . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
An extensive series of Mab ( CD 2 , CD 3 , CD 4 , CD 8 , CD11b , CD 13 , CD 14 , CD 16 , CD 19 , CD 22 , CD 33 , CD 34 , CD 41 , CD42b , CD 45 , CD 56 , CD 61 , CD 64 , CD235a and HLA DR ) were tested singly or in FITC / PE combinations . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The presence of decreased myeloblast CD 45 density , increased CD 13 and CD 34 density , and increased expression of CD11c and CD 4 ( dim ) were MDS grade related . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
CD 3 ( ) CD 4 ( + ) CD 45 ( + ) inducer cells are required for the initiation of mucosa associated organogenesis of both nasopharynx associated lymphoid tissues ( NALT ) and Peyer ' s patches ( PP ) in the aerodigestive tract . ^^^ CXCL 13 ( / ) mice and mice carrying the paucity of lymph node T cell ( plt ) mutation and lacking expression of CCL 19 and CCL 21 accumulate CD 3 ( ) CD 4 ( + ) CD 45 ( + ) cells at the site of NALT but not of PP genesis . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
In this study , we document that soluble gp 180 is able to bind to CD 8 Fc fusion proteins and is absorbed by human CD 8 alpha but not CD 4 transfected murine T cells and that this interaction is dependent upon carbohydrate on the gp 180 molecule . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Mice homozygous for lpr and gld develop profound lymphadenopathy characterized by the expansion of two unusual T cell subsets , a predominant Ly 5 ( B 220 ) + CD 4 CD 8 double negative ( DN ) population and a minor CD 4 dull+ Ly 5 ( B 220 ) + population . ^^^ In addition , CD4+ , CD 4 dull+ Ly 5 ( B 220 ) + , and DN T cells were examined for expression of CD 3 epsilon , TCR alpha / beta heterodimers , Ly 6C , and CD 44 and for proliferative responses to immobilized anti TCR mAb and cofactors . ^^^ In addition , CD 4 dull+ Ly 5 ( B 220 ) + cells closely resembled DN T cells in size and expression of TCR alpha / beta , CD3epsilon , CD 44 , and Ly 6C . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The phenotype was : Thy 1+ , Lyt 1+ ( CD 5 ) , triple negative ( CD 4 , CD 8 , and CD 3 ) , B220+ ( Ly 5 , CD45RA ) , positive for IL 3 receptors , but not IL 2 receptors , and positive for antibodies that react with a putative constant or framework portion of DTH initiating factors such as anti PC 1 F antibodies and 14 30 mAb . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The CH 12 responding population also contains cells with two other phenotypes , Thy 1+ , CD 4 , CD 8 , Ly 5 ( B 220 ) + , sIgM , CD 3 and Thy 1+ , CD4+ , CD 8 , Ly 5 ( B 220 ) , sIgM , CD3+ . ^^^ The Thy 1+ , CD 4 , CD 8 , Ly 5 ( B 220 ) + cells can provide help to CH 12 cells for Ig secretion even in the absence of the nominal antigen for the B lymphoma cells . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
The resultant population lacked CD 4 , CD 8 , and Ig on cell surfaces ; it contained cells bearing Ly 24 ( 27 % ) , Ly 6C ( 6 % ) , and Ly 5 ( B 220 ) detected by 6B2 ( 6 % ) . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
We have identified a rare ( approximately 0 . 05 0 . 1 % ) population of cells ( Thy 1 ( hi ) CD 16 ( + ) CD 44 ( hi ) CD 2 ( ) TCRalphabeta ( ) B 220 ( ) M ac 1 ( ) NK 1 . 1 ( ) ) in the adult mouse bone marrow that generates CD 4 ( + ) and CD 8 ( + ) TCRalphabeta ( + ) T cells after tissue culture for 48 hr in the presence of Ly 5 congenic marrow cells . ^^^
Interacting proteins: P08575 and P01730	Pubmed	SVM Score :0.0
Using the allotypic Ly 5 system , we were able to demonstrate in vivo that T ( r ) cells not only suppress naive CD 4 ( + ) T cells , but also induce them to differentiate into T ( r ) cells . ^^^