| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.50159394 |
| Chimeras between the DR 4 or DR 1 molecules , which interact efficiently with CD 4 , and DRw 53 , which interacts poorly , allowed the mapping of polymorphic residues between positions beta 180 and 189 that can exert a dramatic influence on the interaction with CD4 . . 0.50159394^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| Human herpesvirus 7 induces the functional up regulation of tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) coupled to TRAIL R 1 down modulation in CD 4 ( + ) T cells . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| Increased SA of peripheral blood mononuclear cells ( PBMCs ) and CD 8 T lymphocytes and increased TRAIL receptor 1 expression strongly predicted a poorer recovery of CD 4 T cell count . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| In the presence of IL 2 , human CD 8 ( + ) T cell blasts were more sensitive than CD 4 ( + ) T cell blasts to regulation by APO 2 ligand / TNF related apoptosis inducing ligand ( APO2L / TRAIL ) , while both T cell subsets were equally sensitive to Fas / CD95 regulation . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that soluble recombinant HLA DR 4 molecules from insect cells and HLA DR derived peptides bind to immobilized recombinant soluble CD 4 . ^^^ CD 4 binds recombinant soluble DR 4 heterodimers , as well as the soluble DR 4 beta chain alone . ^^^ Furthermore , two out of twelve DR 4 beta peptides could interact specifically with CD 4 . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| None of the patients with CD 4 lower than 40 % were DR 4 , suggesting that the DR linked resistance gene may predispose to the T cell defect . . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| SCW specific CD 4 T cells restricted by DQw 1 were able to support the growth of CD 8 positive cells , whereas those restricted by DR 4 could not do so . 3 . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| Definition of MHC and T cell receptor contacts in the HLA DR4restricted immunodominant epitope in type 2 collagen and characterization of collagen induced arthritis in HLA DR 4 and human CD 4 transgenic mice . ^^^ Moreover , we demonstrate that HLA DR 4 and human CD 4 transgenic mice homozygous for the 1 Abbeta 0 mutation are highly susceptible to collagen induced arthritis and describe the clinical course and histopathological changes in the affected joints . . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| These results strongly suggest that BV 8 ( + ) CD 4 ( + ) T cells with the described CDR 3 motif recognize a specific antigen presented by DR 4 molecules , indicating the existence of a common vasculitis associated antigen . . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| We show that short term , CD 4 T cell lines derived from six HLA DR 4 individuals showed strong proliferative responses to six of 10 tested peptides of PSA , selected as to contain a DR 4 binding motif . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| We have found that b3a2 peptide specific CD 4 positive T helper cells were able to recognize p210b3a2 positive chronic myelogenous leukemia ( CML ) blasts in a DR 4 restricted manner . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| We used fluorescent , soluble peptide DR 4 complexes ( tetramers ) to detect synovial CD 4 ( + ) T cells reactive with CII and HCgp 39 in DR 4 ( + ) patients . ^^^ The CII DR 4 complex bound in a specific manner to CII peptide reactive T cell hybridomas , but did not stain a detectable fraction of synovial CD 4 ( + ) cells . ^^^ In a small subset of DR 4 ( + ) patients , however , the percentage of synovial CD 4 ( + ) cells binding this complex was above background and could not be attributed to nonspecific binding . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| Melan A / MART 1 ( 51 73 ) represents an immunogenic HLA DR 4 restricted epitope recognized by melanoma reactive CD 4 ( + ) T cells . ^^^ Here we report that this gene also encodes at least one HLA DR 4 presented peptide recognized by CD 4 ( + ) T cells . ^^^ The Melan A / MART 1 ( 51 73 ) peptide was able to induce the in vitro expansion of specific CD 4 ( + ) T cells derived from normal DR 4 ( + ) donors or from DR 4 ( + ) patients with melanoma when pulsed onto autologous dendritic cells . ^^^ Taken together , these data support the use of this Melan A / MART 1 DR 4 restricted melanoma epitope in future immunotherapeutic trials designed to generate , augment , and quantitate specific CD 4 ( + ) T cell responses against melanoma in vivo . . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| Using transgenic mice expressing human DR 4 ( DRB1 * 0401 ) and human CD 4 , but lacking endogenous MHC class 2 , we show that posttranslational glycosylation of type 2 collagen ( CII ) influences the level of T cell tolerance to this candidate cartilage specific autoantigen . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| A vigorous CII specific CD 4 Th1 cell response but not IgG 2 anti CII antibody or CIA could be induced in C57BL / 6 mice made transgenic for the RA shared epitope DR 4 ( B1 * 0401 ) . ^^^ These results confirm our previous observations that the induction of CIA requires a sustained IgG 2 antibody response to CII , an effect difficult to achieve even in DR 4 ( B1 * 0401 ) tg mice reconstituted with CD 4 Th1 cells . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| Alloreactive CD 4 ( + ) T cell clones and lines were generated against HLA DR 11 , DR 13 , DR 4 , and DR 1 MHC Ags , and their rates of migration across untreated EC line Eahy . 926 ( MHC class 2 negative ) or Eahy . 926 transfected with CIITA ( EahyCIITA ) to express DR 11 and DR 13 were investigated . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| We further found that the naturally processed epitopes hTERT ( 766 ) and hTERT ( 672 ) ( which was identified previously ) were promiscuous and capable of inducing CD 4 ( + ) T cell responses in the context of several commonly found HLA DR alleles , including DR 1 , DR 7 , and DR 15 for hTERT ( 672 ) , and DR 4 , DR 11 , and DR 15 for hTERT ( 766 ) . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| Here we show that HLA DR 7 restricted HCMV specific CD 4 ( + ) cytotoxic T lymphocytes ( CTLs ) can display an unusual dual specificity toward a glycoprotein B ( gB ) epitope and the alloantigen HLA DR 4 . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : Although studies have suggested that human cartilage ( HC ) gp 39 may be an antigen recognized by autoreactive CD 4 ( + ) T cells in rheumatoid arthritis , we previously failed to identify specific CD 4 ( + ) T cells in patients ' synovial fluid or blood using a class 2 major histocompatibility complex peptide tetramer composed of the immunodominant HC gp 39 ( 263 275 ) epitope covalently linked to DR 4 . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| CD 4 ( + ) T cell clones that recognized this epitope were isolated from an HLA DR 4 ( + ) child with autoantibodies to insulin , and therefore , at risk for T1D , but not from two healthy HLA DR 4 ( + ) donors . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| However , added N or C terminal amino acids drastically changed HLA and tetramer binding capacity as well as T cell reactivity and the cytokine phenotype of the P Ins ( 73 90 ) specific human CD 4 T cell clone , suggesting a potential for this P Ins epitope as a target for therapeutic intervention in HLA DR 4 positive humans with beta islet cell autoimmunity or recent onset type 1 diabetes . . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| This Tg mouse line was crossed to human CD 4 ( hCD 4 ) Tg mice and endogenous class 2 knockout mice ( 1 A ( o / o ) and 1 E ( o / o ) ) lines to generate a DR 4 DQ3 . hCD4 . ^^^ Furthermore , the DR 4 DQ3 restricted CD 4 ( + ) T cells conferred protective antibody mediated immunity against an otherwise lethal infection with Salmonella enterica var . typhimurium . ^^^ |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00220 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|