| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.55673021 |
| CONCLUSIONS : We conclude that IL 1 beta is synthesised , in conjunction with caspase 1 , by endothelial , inflammatory , and adventitial cells early ( within 3 days ) after PTCA , with decreased levels at later timepoints , suggesting that it has a key role to play in the early stages of healing following PTCA . . 0.55673021^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We have purified the IL 1 beta converting enzyme from the THP 1 cell line using standard chromatographic techniques and obtained the N terminal amino acid sequence of this novel protein . ^^^ An antiserum raised against a peptide based on the N terminus was used to precipitate the protease , confirming our identification of the 22 , 000 Da protein as the IL 1 beta converting enzyme . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Molecular cloning of the murine IL 1 beta converting enzyme cDNA . ^^^ This cleavage is catalyzed by a specific protease that has been designated the IL 1 beta converting enzyme ( or IL 1 beta convertase ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Purification and cloning of the complementary DNA indicates that IL 1 beta converting enzyme is composed of two nonidentical subunits that are derived from a single proenzyme , possibly by autoproteolysis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1 converting enzyme ( ICE ) specifically cleaves the human IL 1 beta precursor at two sequence related sites : Asp 27 Gly28 ( site 1 ) and Asp 116 Ala117 ( site 2 ) . ^^^ To further examine the substrate specificity of ICE , proteins that contain Asp 10 linkages including transferrin , actin , complement factor 9 , the murine IL 1 beta precursor , and human and murine IL 1 alpha precursors , were assayed for cleavage by 500 fold purified ICE . ^^^ The human and murine IL 1 beta precursors were the only proteins cleaved by ICE , demonstrating that ICE is an IL 1 beta convertase . ^^^ Analysis of human IL 1 beta precursor mutants containing amino acid substitutions or deletions within each processing site demonstrated that omission or replacement of Asp at site 1 or site 2 prevented cleavage by ICE . ^^^ These results show that ICE is a highly specific IL 1 beta convertase with absolute requirements for Asp in P 1 and a small hydrophobic amino acid in P1 ' . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Furthermore , calpain did not enhance the processing of the IL 1 beta precursor by the IL 1 beta converting enzyme . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The interleukin 1 beta converting enzyme ( ICE ) is the cysteine proteinase responsible for cleaving the 31 kDa interleukin 1 beta ( IL 1 beta ) precursor to its active 17 kDa form . ^^^ Activated cells treated with YVAD emk and ATP or CTL showed no mature IL 1 beta in either the cell lysates or the culture supernatants , indicating effective inhibition of ICE activity ; however , the YVAD treated macrophages showed no detectable change in 51Cr release or nuclear fragmentation , indicating failure to inhibit apoptotic cell death . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The interleukin 1 beta ( IL 1 beta ) converting enzyme ( ICE ) processes the inactive IL 1 beta precursor to the proinflammatory cytokine . ^^^ Adherent monocytes from mice harboring a disrupted ICE gene ( ICE / ) did not export IL 1 beta or interleukin 1 alpha ( IL 1 alpha ) after stimulation with lipopolysaccharide . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Similarly , the expression of bcl 2 , bcl 10 , bax and IL 1 beta converting enzyme did not correlate with susceptibility to anti IgM induced PCD . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Despite constitutive expression of mRNA for both IL 1 beta and the IL 1 beta converting enzyme ( ICE ) , XS 52 cells secreted no detectable IL 1 beta spontaneously . ^^^ IL 1 beta secretion was associated with a striking up regulation of IL 1 beta mRNA and a modest up regulation of ICE mRNA and enzymatic activity . ^^^ IL 1 beta secretion was blocked by Ac YVAD CHO ( a peptide inhibitor of ICE ) , CTLA 4 Ig fusion protein , or anti Ia mAb . ^^^ Thus , the XS 52 dendritic cell line secretes , by an ICE dependent mechanism , biologically relevant amounts of IL 1 beta upon Ag dependent interaction with T cells , with both Ia molecules and B 7 related molecules playing essential roles . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| A potent , reversible , tetrapeptide inhibitor of interleukin 1 beta converting enzyme ( ICE ) , L 709 , 049 , has been shown to suppress the in vitro production of mature IL 1 beta . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to determine whether LC express mRNA for the IL 1 beta converting enzyme ( ICE ) , a protease that is required for processing pro IL 1 beta into an active form . ^^^ Here , we report that both IL 1 beta and ICE mRNA are expressed by the Ia+ population ( i . e . ^^^ Moreover , murine epidermal derived DC lines ( XS series ) also express both IL 1 beta and ICE mRNA , and they secrete relatively large amounts of IL 1 beta following lipopolysaccharide ( LPS ) stimulation . ^^^ Finally , LPS triggered IL 1 beta secretion by XS cells is blocked almost completely by the ICE inhibitor acetyl Tyr Val Ala Asp CH2OC ( O ) [ 2 , 6 ( CF 3 ) 2 ] Ph . ^^^ These results demonstrate that LC are the primary source of IL 1 beta within the epidermis , and suggest that the proinflammatory role of IL 1 beta may be regulated pharmacologically by ICE inhibitors in vivo . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We report here that the activation of the interleukin 1 beta ( IL 1 beta ) converting enzyme ( ICE ) family is likely to be one of the crucial events of tumor necrosis factor ( TNF ) cytotoxicity . ^^^ Induction of apoptosis in HeLa cells by TNF alpha / CHX is associated with secretion of mature IL 1 beta , suggesting that an IL 1 beta processing enzyme , most likely ICE itself , is activated by TNF alpha / CHX stimulation . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Consistent expression in the BM and PB of all tested individuals was also observed for IL 1 beta , IL 1 receptor antagonist , and IL 1 beta converting enzyme , which are all members of the IL 1 family with a possible indirect effect on hematopoiesis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| ICE and granzyme B share the rare substrate site of aspartic acid , after which amino acid cleavage of precursor IL 1 beta ( pIL 1 beta ) occurs . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p 30 ICE precursor , but not to generate mature IL 1 beta from pro IL 1 beta . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We speculate that PGE 2 could inactivate the IL 1 beta converting enzyme which is essential for processing and secretion of mature IL 1 beta . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1 alpha and mature 17 kD IL 1 beta ( cleaved from precursor by IL 1 beta converting enzyme ) bind to the type 1 IL 1 receptor to transduce a signal . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Modulation of acute myeloblastic leukemia ( AML ) cell proliferation and blast colony formation by antisense oligomer for IL 1 beta converting enzyme ( ICE ) and IL 1 receptor antagonist ( IL 1ra ) . ^^^ To examine the role of pro IL 1 processing , antisense technology was employed with 16 mer phosphorothioate oligodeoxynucleotide directed against human IL 1 beta converting enzyme ( ICR ) in 7 randomly selected AML cases . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1 beta converting enzyme ( ICE ) , the first member of a newly discovered family of cysteine proteinases , is required for this processing event . ^^^ The results indicate that ICE , in addition to its processing function , facilitates the transport of IL 1 beta across the plasma membrane . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) is responsible for processing an inactive 31 kDa precursor to the active , mature 17 kDa Il 1 beta with cleavage occurring between the Asp 116 Ala117 amide bond . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The active cytokine is generated by proteolytic cleavage of an inactive precursor by a protease called the IL 1 beta converting enzyme ( ICE ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta ( IL 1 beta ) converting enzyme ( ICE ) processes the precursor of the cytokine IL 1 beta to a mature , biologically active form in monocytes and macrophages . ^^^ To further understand the role of ICE in regulating IL 1 beta mediated biological functions , we have isolated several genomic clones encoding the full length murine ICE gene . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Human interleukin 1 beta ( IL 1 beta ) is synthesized as an inactive precursor that is cleaved by IL 1 converting enzyme ( ICE ) between Asp 116 and Ala 117 to form COOH terminal mature IL 1 beta and NH 2 terminal IL 1 beta propeptide . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The IL 1 beta converting enzyme as a therapeutic target . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The proinflammatory cytokine IL 1 beta is synthesized by activated monocytes and macrophages as a 31 kDa , biologically inactive precursor that is proteolytically processed to the biologically active 17 kDa mature molecule by the IL 1 beta converting enzyme ( ICE ) . ^^^ The effect was specific to mature IL 1 beta release ; the ICE inhibitor did not effect IL 1 beta RNA levels or precursor protein synthesis . ^^^ The ability to selectively inhibit mature IL 1 beta release in vivo with ICE inhibitors will allow for detailed studies of the role of IL 1 beta and ICE in inflammatory diseases . . ^^^ Inhibition of mature IL 1 beta production in murine macrophages and a murine model of inflammation by WIN 67694 , an inhibitor of IL 1 beta converting enzyme . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1 beta converting enzyme ( ICE ) cleaves pro IL 1 beta to generate mature IL 1 beta . ^^^ We generated ICE deficient mice and observed that they are overtly normal but have a major defect in the production of mature IL 1 beta after stimulation with lipopolysaccharide . ^^^ ICE therefore plays a dominant role in the generation of mature IL 1 beta , a previously unsuspected role in production of IL 1 alpha , but has no autonomous function in apoptosis . . ^^^ Mice deficient in IL 1 beta converting enzyme are defective in production of mature IL 1 beta and resistant to endotoxic shock . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta ( IL 1 beta ) processing in murine macrophages requires a structurally conserved homologue of human IL 1 beta converting enzyme . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) is a cysteine protease that catalyzes the conversion of the inactive precursor form of IL 1 beta to an active mature form . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta ( IL 1 beta ) converting enzyme ( ICE ) is a cysteine protease that specifically cleaves precursor IL 1 beta to its biologically active form . ^^^ The ICE inhibitor suppressed OCI / AML3 growth in a dose dependent manner ( at 0 . 4 to 4 mumol / L ) and downregulated mature IL 1 beta production , as assessed by Western immunoblotting . ^^^ The ICE inhibitor suppressed proliferation of AML precursors ( by up to 78 % ; mean , 44 % ) in a dose dependent fashion at concentrations ranging from 0 . 4 to 5 mumol / L but not proliferation of normal marrow progenitors ; the suppressive effect was reversed by IL 1 beta . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Secretion of human monocyte mature IL 1 beta : optimization of culture conditions and inhibition by ICE inhibitors . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Differing from ICE , the ACA could not process pro IL 1 beta to mature IL 1 beta . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Both PARP proteolysis and the proapoptotic effects of the protease are inhibited by nanomolar concentrations of a selective inhibitor of apopain ( CPP 32 ) , while an inhibitor of IL 1 beta converting enzyme is much less effective , requiring micromolar concentrations for the inhibition of the isolated protease . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Further , there was a relatively good correlation between IL 1 beta bioactivity and IL 1 beta converting enzyme ( ICE ) activity , suggesting that bioactive IL 1 beta is possibly generated through the action of ICE . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Conversely , the IL 1 beta converting enzyme inhibitor , Ac Tyr Val Ala Asp CHO ( L 709 , 049 ) and the anti inflammatory agent [ 5 ( 4 pyridyl ) 6 ( 4 fluorophenyl ) 2 , 3 dihydroimidazo ( 2 , 1 b ) thiazole ] ( SK & F 86002 ) inhibited IL 1 beta release in both the standard and staged release assays with IC 50 of 1 microM . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| When purified proIL 1 beta is cleaved by increasing concentrations of IL 1 beta converting enzyme or porcine pancreatic elastase , there is a dose dependent increase in the signal from the conventional IL 1 beta ELISA and a concurrent decrease in signal from the proIL 1 beta specific ELISA . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin ( IL ) 1 beta converting enzyme ( ICE ) cleaves the biologically inactive precursor form of IL 1 beta into mature , bioactive IL 1 beta . ^^^ In a second set experiments , we found that the genes encoding not only ICE , but also IL 1 alpha , IL 1 beta , IL 1 receptor antagonist ( IL 1ra ) , and the IL 1 type 1 receptor are expressed in brain vasculature . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In these cells as well as in monocytes , lipopolysaccharide stimulation did not change the pattern of ICE expression , although efficient secretion of mature IL 1 beta was measured . ^^^ Our results , therefore , show that ICE is present in cells as a large pool of intracytoplasmic precursor , and that very limited amounts of mature ICE protein are present , but nevertheless sufficient to allow efficient IL 1 beta cleavage . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Fas mediated apoptosis could also be prevented in a CD4+ or CD8+ T cell type manner ( 1 ) by several protease antagonists , suggesting the involvement of the interleukin 1beta ( IL 1beta ) converting enzyme ( ICE ) related cysteine protease in CD4+ T cell death and of both a CPP 32 related cysteine protease and a calpain protease in CD8+ T cell death ; and ( 2 ) by three cytokines , IL 2 , IL 12 , and IL 10 , that exerted their effects through a mechanism that required de novo protein synthesis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The IL 1 beta converting enzyme ( ICE ) , a novel cysteine protease , is required for processing of the 31 kDa IL 1 beta precursor to generate the 17 kDa proinflammatory mature form . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We examined the mRNA levels for various cytokines , including IL 1 alpha , IL 1 beta , TNF alpha , TGF beta 1 , GM CSF , IL 6 , IL 8 , bFGF , PDGF A , PDGF B and IL 1ra , and IL 1 beta converting enzyme , and the protein levels of some of these cytokines in 19 SV 40 transformed synovial cell clones . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1 beta is produced as an inactive 31 kDa precursor processed to active 18 kDa IL 1 beta by proteolytic cleavage , catalyzed by the highly specific IL 1 converting enzyme ( ICE ) . ^^^ Human keratinocytes express IL 1 beta , but not active ICE . ^^^ We conclude that human plantar stratum corneum contains biologically active IL 1 beta that has been activated by an alternative mechanism that does not involve ICE . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Prointerleukin 1 beta ( pro IL 1 beta ) is the only known physiologic substrate of the interleukin 1 beta ( IL 1 beta ) converting enzyme ( ICE ) , the founding member of the ICE / ced 3 cell death gene family . ^^^ We also demonstrate that Ice , when expressed in COS cells , requires the coexpression of pro IL 1 beta for the induction of apoptosis , which is inhibited by IL 1Ra . ^^^ Our findings demonstrate that pro IL 1 beta is a substrate of ICE relevant to cell death , and depending on the temporal cellular commitment to apoptosis , mature IL 1 beta may function as a positive or negative mediator of cell death . . ^^^ Functional role of interleukin 1 beta ( IL 1 beta ) in IL 1 beta converting enzyme mediated apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The present study was carried out to determine whether those factors which regulate the expression of IL 1 beta in immune and non immune tissues are also able to regulate the expression of ICE . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that HIV 1 induced apoptosis of the H 9 human T cell line is blocked by peptide inhibitors of IL 1 beta converting enzyme ( ICE ) family proteases , but not by the antagonistic M 3 anti Fas Ab . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Fas mediated apoptosis has been shown to be mediated by the IL 1beta converting enzyme ( ICE ) pathway . ^^^ To determine the relationship between ICE and its substrate IL 1beta , we examined six human cell lines for susceptibility to Fas mediated apoptosis and Fas induction of ICE like activity . ^^^ To examine whether intracellular IL 1beta is a proteolytic substrate or an endogenous competitive inhibitor against other substrates for Fas ICE mediated apoptosis in SKW6 . 4 cells , we established precursor IL 1beta transfectant clones using SKW6 . 4 cells . ^^^ We demonstrated that stably transfected SKW6 . 4 cells expressing precursor IL 1beta , but not cells transfected with the empty vector , exhibited resistance to Fas mediated apoptosis due to competitive inhibition of ICE like activity , which was associated with increased cleavage of precursor IL 1beta to mature IL 1beta . ^^^ These results suggest that Fas mediated apoptosis is mediated by ICE cleavage of proteolytic substrates other than IL 1beta and that IL 1beta is an endogenous inhibitor of Fas mediated apoptosis . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Ischemic injury is also reduced in mice that fail to produce IL 1 beta because of an abnormal interleukin 1 beta converting enzyme gene ( ICE knockout mice ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) , involved in the maturation process of interleukin 1 beta ( IL 1 beta , is a homologue of ced 3 , a protease required for programmed cell death in Caenorhabditis elegans . ^^^ We show that ICE mRNA expression is increased 4 fold in the cerebellum of homozygous staggerer mice , where IL 1 beta mRNA is overexpressed and programmed neuronal cell death occurs . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the IL 1 beta converting enzyme ( ICE ) family cysteine proteases responsible for the Fas mediated apoptosis of rheumatoid arthritis ( RA ) synoviocytes and their involvement in proinflammatory cytokine production . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The deletion of 162 nucleotides did not result in a frame shift but spliced out the putative exon 5 of the IL 1 beta gene which includes the cleavage site for the IL 1 beta converting enzyme ( ICE ) in human and murine IL 1 beta . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| On the other hand , a specific tetrapetide aldehyde inhibitor of ICE significantly retarded the apoptotic death of BMAM cells at 1 mumol / L in 5 / 6 MDS cases studied ( AI % = 2 . 99 + / 0 . 30 in controls 5 1 . 58 + / 0 . 40 with ICE inhibitor , P = . 05 ) and also reduced the levels of active IL 1 beta synthesized ( 5 . 59 + / 2 . 63 5 2 . 24 + / 0 . 93 pg / 10 ( 6 ) cells , respectively ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta ( IL 1 beta ) converting enzyme ( ICE ) cleaves pro IL 1 beta to produce mature IL beta , and is a member of a family of proteases implicated in apoptosis . ^^^ Inhibition of ICE could reduce ischaemic damage either by preventing IL 1 beta synthesis or by inhibiting apoptosis or by both of these processes , and may provide a useful therapeutic approach to the inhibition of ischaemic brain damage . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IpaB activates apoptosis by binding to interleukin 1 beta ( IL 1 beta ) converting enzyme ( ICE ) or a highly homologous protease . ^^^ In double labeling experiments , we show that IpaB and ICE colocalize in the cytoplasm of the macrophage , suggesting that soon after secretion , IpaB binds to ICE to initiate apoptosis and to promote the cleavage of IL 1 beta . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| This indicates a dissociation of IL 1 beta synthesis and secretion and is indicative of an IL 1 beta converting enzyme similar to that which has been described in the human and mouse models . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) processes the inactive prolL 1 beta to the proinflammatory mature IL 1 beta . ^^^ ICE deficient mice had a major defect in the production of mature IL 1 beta and had impaired IL 1 alpha production on LPS stimulation in vitro and in vivo . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1 beta converting enzyme ( ICE ) cleaves pro IL 1 beta to the mature , released form . ^^^ Although other proteases can process pro IL 1 beta , ICE deficient ( ICE / ) mice do not release mature IL 1 beta in response to endotoxin . ^^^ No differences were observed in the development of the systemic acute phase response after turpentine administration between wild type and ICE / mice , but this response was completely impaired in IL 1 beta / mice . ^^^ Accordingly , the levels of mature IL 1 beta produced in response to turpentine did not differ between wild type and ICE / mice . ^^^ In contrast , following zymosan induced peritonitis , the levels of mature IL 1 beta were significantly lower in ICE / mice . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Despite its inhibition of ICE , B13R does not prevent fever in infected mice , a systemic effect mediated by IL 1beta . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Tripeptide and pentapeptide aldehydes as substrate base inhibitors of cysteine proteases were designed in our laboratory for the inhibition of interleukin 1 beta converting enzyme ( ICE ) , a recently described cysteine protease responsible for the processing of IL 1 beta . ^^^ These findings indicate that these peptide aldehydes might be used as IL beta inhibitory agents in experimental models in which IL 1 beta is a key mediator or ICE is implicated . . ^^^ Effect of peptide aldehydes with IL 1 beta converting enzyme inhibitory properties on IL 1 alpha and IL 1 beta production in vitro . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1 beta convertase ( ICE ) does not play a requisite role in apoptosis induced in T lymphoblasts by Fas dependent or Fas independent CTL effector mechanisms . ^^^ Both IL 1beta convertase ( ICE ) and other members of the ICE like family of proteases have been reported to play a role in Fas mediated apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The interleukin 1beta ( IL 1beta ) converting enzyme ( ICE ) processes the inactive IL 1beta precursor to the proinflammatory cytokine . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Thus , we investigated the expression and function of IL 1beta converting enzyme ( ICE ) in vascular cells . ^^^ Despite the failure of SMC to process IL 1beta , these cells expressed ICE mRNA , immunoreactive ICE protein , and the expected IL 1beta nucleotide sequence . ^^^ The lack of processing was explained by our finding that extracts of SMC specifically and concentration dependently blocked processing of IL 1beta precursor by recombinant or native ICE . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Regulation of IL 1 beta levels can be achieved both at transcriptional and translational level and in particular at the posttranslational , ICE catalysed , level . ^^^ Thus , we examined ICE activity in rats under conditions of systemic stimulation by intraperitoneal ( i . p . ) injections of lipopolysaccharide ( LPS ) from E . coli , which are known to dramatically alter IL 1 beta mRNA and protein levels . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| During reperfusion after filamentous middle cerebral artery occlusion , ICE like cleavage products and tissue immunoreactive interleukin 1beta ( IL 1beta ) levels increased in ischemic mouse brain . ^^^ FMK decreased ICE like cleavage products and tissue immunoreactive IL 1beta levels in ischemic mouse brain and reduced tissue damage when administered to rats as well . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Because secretion of IL 1 beta is dependent on intracellular processing of pro IL 1 beta by IL 1 converting enzyme ( ICE ) , we aimed to determine the efficacy of a novel ICE inactivator ( VE 13045 ) in inhibiting secretion of active IL 1 beta in vivo and if the loss of ICE activity would affect the severity and mortality of experimental pancreatitis . ^^^ Acute pancreatitis was associated with a 120 fold increase in IL 1 beta mRNA , which was not affected by ICE inhibition or gene deletion . ^^^ Cytokine processing and secretion were affected , as evidenced by decreased serum levels of IL 1 beta and TNF alpha ( p < 0 . 001 ) in all animals with an inactive ICE enzyme . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The gene for its prominent IL 1 beta form produces a 31 kDa precursor protein ( pro IL 1 beta ) that is biologically inactive unless cleaved to its mature form by a cytoplasmic cysteine protease termed Il 1 beta converting enzyme ( ICE ) . ^^^ It was therefore hypothesized that ICE may either augment the production of mature IL 1 beta and stimulate the proliferation of cells , in which IL 1 beta acts as an autocrine growth factor , or induce apoptosis . ^^^ Unlike ICE , the other members of this family do not cleave pro IL 1 beta but are effective inducers of apoptotic cell death , whereas ICE acts primarily as an IL 1 beta converting enzyme . ^^^ Because IL 1 beta serves as either an autocrine or paracrine growth factor in AML , we recently investigated the effect of ICE inhibition on AML colony growth and found that ICE inhibition reduced the production of mature IL 1 beta and suppressed AML progenitor proliferation . ^^^ Our data suggest that ICE does not function as an apoptosis gene in AML but rather increases mature Il 1 beta production and AML cell proliferation . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| ICE , essential for IL 1 beta production and , thus , critical to necrotic mechanisms , also plays a role in apoptosis mediated through the stimulation of the lymphocyte fas antigen . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Benzoquinone was also shown to completely inhibit the ability of the SH dependent IL 1 beta converting enzyme . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| These mice are deficient in processing pro IL 1 beta , indicating that mutant ICEC285G blocks ICE function . ^^^ Since ICE is the only enzyme with IL 1 beta convertase activity in mice , our data indicates that the mutant ICEC285G inhibits ICE , and hence mature IL 1 beta production , and through this mechanism , at least in part , inhibits apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The cellular production of IL 1beta , a cytokine implicated in a variety of inflammatory diseases , requires cleavage of its precursor ( proIL 1beta ) at an Asp 10 site by interleukin 1beta converting enzyme ( ICE , recently termed caspase 1 ) . ^^^ A selective caspase 1 inhibitor blocks both lipopolysaccharide induced IL 1beta and IFN gamma production from human mononuclear cells . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In this study , the inhibition of the cysteine protease , interleukin 1 beta ( IL 1 beta ) converting enzyme ( ICE ) , by HNE in human blood mononuclear cells was investigated . ^^^ Thus , low levels of HNE can suppress mononuclear cell release of IL 1 beta , probably by interacting with the active site cysteine of ICE . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| These include the proto oncogene bcl 2 and related molecules , the family of proteases which share homology with IL 1 beta converting enzyme ( ICE ) and another protein family which interact with products of the proto oncogene c myc . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Keratinocytes express IL 1 beta but not the active form of the specific IL 1 beta converting enzyme ( ICE ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Interleukin 1beta converting enzyme ( ICE / caspase 1 ) is the protease responsible for interleukin 1beta ( IL 1beta ) production in monocytes . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The discovery of ICE , a unique processing enzyme involved in the production of active IL 1 beta , has provided a new approach to specifically block the production of this potent cytokine . ^^^ The studies comparing IL 1 beta and ICE deficient mice suggest that complete abrogation of IL 1 beta is required to achieve efficacy in models of inflammation . ^^^ Understanding the source of the residual IL 1 beta produced in ICE deficient mice will be important in order to ascertain if a similar mechanism could generate active IL 1 beta in patients receiving if a ICE inhibitor . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1 beta converting enzyme mRNA remained unchanged . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| As shown previously , human vascular wall cells , such as smooth muscle cells ( SMC ) , express the IL 1beta precursor upon stimulation and the IL 1beta converting enzyme ( ICE ) constitutively but do not produce mature IL 1beta or express ICE activity . ^^^ We report here that stimulation of human vascular SMC and endothelial cells ( EC ) through CD 40 ligand , a mediator recently localized in human atheroma , induced elaboration of the IL 1beta precursor as well as activation of cell associated ICE . ^^^ These findings establish a novel mechanism of IL 1beta activation in human vascular cells and , moreover , indicate a new pathway of ICE activation , which could participate in inflammatory aspects of atherogenesis and other disease states . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In vitro studies suggest that M phi Ao can be induced by IL 1 beta via interleukin 1 beta converting enzyme ( ICE , a cysteine protease ) , prostanoids , or reactive oxygen / nitrogen . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1 beta converting enzyme ( ICE ) , a proteolytic enzyme that converts the inactive precursor of interleukin 1 beta ( IL 1 beta ) to its mature active form , has been abundantly detected in the IL 1 beta producing cells in the spleen . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The growth inhibition was associated with a rapid but transient downregulation of IL 1beta and IL 1beta converting enzyme ( ICE ) mRNAs in 1 , 25D3 and 20 epi analogue treated cells , and the 20 epi analogue was more effective than 1 , 25D3 in repressing ICE expression . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| It is concluded that psoriatic scales contain biologically active IL 1 beta , which has been processed by a mechanism which may be similar to that present in non inflamed plantar stratum corneum , and which does not involve IL 1 beta converting enzyme . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1beta converting enzyme ( ICE ) family cysteine proteases are subdivided into three groups ; ICE , CPP 32 , and Ich 1 like proteases . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| To investigate the effect of term labour without infection on the IL 1 system , the messenger ribonucleic acid ( mRNA ) expression of IL 1 beta , IL 1 receptor type 1 ( IL 1R tI ) , IL 1 receptor antagonist ( IL 1ra ) , and IL 1 beta converting enzyme ( ICE ) were examined by Northern blot analysis and by reverse transcriptase polymerase chain reaction ( RT PCR ) in paired samples of decidua and placenta obtained from women having spontaneous vaginal delivery ( group 1 ) or elective caesarean section ( group 2 ) at term . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Whereas the precursor ( pro ) 31 kDa form of IL 1 alpha is biologically active , pro IL 1 beta is inactive unless cleaved to its mature form by a cytoplasmic cysteine protease termed IL 1 beta converting enzyme ( ICE ) . ^^^ However , recent data indicate that ICE is a member of an increasingly recognized family of ICE related molecules whose other members , such as CPP 32 , do not cleave pro IL 1 beta but rather are effective inducers of apoptotic cell death . ^^^ We found that inhibition of ICE reduced the production of mature IL 1 beta and suppressed the proliferation of AML colony forming units , confirming the central role of IL 1 beta in AML progenitor proliferation . ^^^ These data suggest that the primary role of ICE in AML cells is cleavage of pro IL 1 beta rather than induction of apoptosis and that the antileukemic activity of specific ICE inhibitors warrants further exploitation . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1beta maturation was severely retarded by YVAD , indicating that IL 1beta converting enzyme ( ICE ; caspase 1 ) is activated in Shigella induced apoptosis . ^^^ The finding that Shigella induces apoptosis in human macrophages by activating ICE supports the hypothesis that the acute inflammation characteristic of shigellosis is initially triggered by apoptotic macrophages which release mature IL 1beta during programmed cell death . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The expression of IL 1beta , IL 1 Receptor 1 ( IL 1R1 ) , Il 1R2 , IL 1R antagonist ( IL 1Ra ) , and ICE mRNA within the pancreas was examined by quantitative differential RT PCR . ^^^ There was constitutive expression of pancreatic IL 1R1 , IL 1R2 , IL 1Ra , and ICE but not IL 1beta . ^^^ As pancreatitis developed , mRNA for IL 1beta , IL 1Ra , and ICE increased in parallel with the degree of pancreatitis severity ( all P < 0 . 001 vs baseline ) while mRNA for both receptors remained stable ( P=NS ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The expression of mRNAs for interferon regulatory factor 1 ( IRF 1 ) , IL 1beta converting enzyme ( ICE ) , and IL 1beta in the cells was analyzed semiquantitatively by reverse transcriptase PCR . ^^^ Before RSV exposure , some IRF 1 , ICE , and IL 1beta transcripts were already expressed in the monocytes . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1beta converting enzyme ( ICE ) is a key enzyme of the apoptotic machinery involved in Fas mediated apoptosis of normal lymphocytes . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The interleukin 1 beta converting enzyme ( ICE ) was first identified as a unique cysteine protease that processes the inactive precursor of the pro inflammatory cytokine IL 1 beta to its mature active form . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| That dexamethasone inhibited the expression of ICE , suggests that corticosteroids regulate the secretion of IL 1beta by microglial cells , in part , by regulating the expression of ICE . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 18 is synthesized as a precursor molecule without a signal peptide but requires the IL 1beta converting enzyme ( ICE , caspase 1 ) for cleavage into a mature peptide . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Because IL 1 beta converting enzyme ( ICE ) is required for the conversion of proIL 1 beta to its biologically active form , and has homology with proteins that regulate apoptosis in invertebrates , we studied the effect of cerebral ischemia on brain injury in mutant mice deficient in the ICE gene ( ICE knockout [ KO ] mice ) . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Production of both IL 1alpha and IL 1beta after lipopolysaccharide stimulation , a crucial event during septic shock and an indication of ICE activation , is blocked in casp 11 mutant mice . casp 11 mutant embryonic fibroblast cells are resistant to apoptosis induced by overexpression of ICE . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| An IL 1 beta converting enzyme inhibitor blocks proteolysis of IL 1 beta , but it does not prevent release of pro IL 1 alpha , pro IL 1 beta , or LDH . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The Nef induced apoptosis as well as Fas mediated apoptosis was inhibited by acetyl Try Val Ala Asp CHO , an IL 1beta converting enzyme ( ICE ) inhibitor . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Apoptosis was significantly inhibited by an interleukin 1beta ( IL 1beta ) converting enzyme ( ICE ) / CED 3 family protease inhibitor , Ac DEVD CHO ( CPP 32 ; caspase 3 ) , whereas a similar inhibitor of ICE ( caspase 1 ) , Ac YVAD CHO , had no effect . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We have used an assay determining the caspase 1 activity based on cleavage of a fluorogenic peptide substrate to elucidate its role in lipopolysaccharide ( LPS ) induced secretion of IL 1 beta . ^^^ Caspase 1 activation by LPS was associated with cleavage of the IL 1 beta precursor protein that was followed by release of the mature IL 1 beta protein in monocytic cells . ^^^ LPS induced caspase 1 activation appeared not to result from modulation of caspase 1 transcript accumulation and inhibition of caspase 1 activity was accomplished by two specific inhibitors , YVAD CHO and YVAD CMK , capable of alleviating the release of mature IL 1 beta . ^^^ Taken together , these results show that LPS moderately activates caspase 1 and that caspase 1 activation contributes to LPS induction of IL 1 beta secretion . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : In the lipopolysaccharide ( LPS ) stimulated peripheral blood monocyte , the precursor form of interleukin 1 beta ( IL 1 beta , 31 kD ) is processed by IL 1 beta converting enzyme ( ICE ) to the mature , bioactive form ( 17 kD ) . ^^^ AIMS : To investigate the expression and processing of IL 1 beta and ICE by tissue macrophages from normal and IBD colonic mucosa . ^^^ Ac Tyr Val Ala Asp CHO , a specific peptide aldehyde inhibitor of ICE , significantly reduced the amount of mature IL 1 beta released by isolated IBD macrophages ( from a median of 1 . 2 ( range 0 . 78 4 . 42 ) ng / ml to 0 . 43 ( 0 . 21 1 . 6 ) ng / ml ; p < 0 . 01 ) . ^^^ CONCLUSIONS : Exposure of normal colonic macrophages to LPS only induces the production of the precursor form of IL 1 beta , because the cells fail to activate ICE . ^^^ In contrast , IBD colonic macrophages are able to activate ICE and hence release mature IL 1 beta in a manner similar to circulating monocytes . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1 beta converting enzyme ( ICE ) is present and functional in human alveolar macrophages : macrophage IL 1 beta release limitation is ICE independent . ^^^ Since it has been hypothesized that IL 1beta processing by the IL 1beta converting enzyme ( ICE ) regulates IL 1beta release , we compared human alveolar macrophages and human blood monocytes for relative ICE expression and activation . ^^^ Furthermore , an indirect assay for functional ICE documents similar ICE activities in both monocytes and alveolar macrophages , i . e . , similar concentrations of soluble synthetic ICE inhibitor ( IC 50 values of 0 . 3 + / 0 . 01 and 0 . 6 + / 0 . 2 microM , respectively ) are required to block mature IL 1beta generation . ^^^ These findings document that the macrophage limitation in mature IL 1beta release is not due to a lack of ICE or to an inability to activate ICE . ^^^ Taken together , these findings suggest that macrophage IL 1beta export is regulated independently of ICE activation . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1beta , a major mediator of inflammatory and immunologic skin disease , undergoes post translational site specific cleavage by a novel cysteine protease termed IL 1beta converting enzyme ( ICE ) . ^^^ In this study , we examined whether haptens and inflammatory agents might serve as stimuli for ICE activity in human keratinocytes , and , if so , whether ICE activity might precipitate enzymatic processing of IL 1beta to its 17 . 5 kDa form . ^^^ Enzymatic conversion from the 31 kDa to the 17 . 5 kDa form of IL 1beta was blocked by addition of a highly specific aldehyde inhibitor that contained a tetrapeptide recognition sequence specific for ICE , but not by an aldehyde inhibitor of a related ICE like cysteine protease . ^^^ Induction of biologically active IL 1 beta converting enzyme and mature IL 1 beta in human keratinocytes by inflammatory and immunologic stimuli . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Active IL 1beta is produced by interleukin converting enzyme ( ICE ) , a caspase thought to be involved in the induction of apoptosis . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Mice deficient in IL 1 beta , IL 1 beta converting enzyme ( ICE ) and IL 1R type 1 have also been studied . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Addition of the irreversible interleukin 1beta converting enzyme ( ICE ) inhibitor , Z Val Ala Asp dichlorobenzoate , or a radicicol analog , inhibited nigericin induced mature IL 1beta release and activation of p 45 ICE precursor . ^^^ We have therefore shown conclusively , for the first time , that nigericin induced release of IL 1beta is dependent upon activation of p 45 ICE processing . ^^^ So far , the mechanism by which reduced intracellular potassium ion concentration triggers p 45 ICE processing is not known , but further investigation in this area could lead to the discovery of novel molecular targets whereby control of IL 1beta production might be effected . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1 beta converting enzyme ( ICE ) , also known as caspase 1 , subserves two dichotomous biologic roles . ^^^ We show here that two different proinflammatory stimuli , LPS and granulocyte macrophage CSF , up regulate the expression of both ICE and IL 1 beta in human polymorphonuclear neutrophils , and that the ICE dependent cleavage of pro IL 1 beta results in delayed expression of the constitutive cell death program . ^^^ We conclude that caspase 1 ( ICE ) subserves both pro and antiapoptotic roles ; the latter role is evident during inflammation as an inhibition of spontaneous neutrophil apoptosis through the processing of IL 1 beta . ^^^ The ICE dependent activation of IL 1 beta may represent a common autocrine pathway for the divergent stimuli that inhibit the constitutive expression of neutrophil programmed cell death during inflammation . . ^^^ The IL 1 beta converting enzyme ( caspase 1 ) inhibits apoptosis of inflammatory neutrophils through activation of IL 1 beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The authors conclude that the IL 1 beta species present in plantar stratum corneum have isoelectric points determined by their respective amino acid sequences , and that there is a mechanism for IL 1 beta activation in human epidermis not involving interleukin 1 beta convertase . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The apoptotic response was not affected significantly by peptide inhibitors of IL 1beta converting enzyme ( ICE ) like proteases and CPP 32 . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The IL 1beta converting enzyme ( ICE ) inhibitor Ac YVAD CMK annulled the adrenal response to LPS , but did not affect that to IL 1beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1 beta is synthesized as an inactive precursor , which is subsequently processed by IL 1 beta converting enzyme ( ICE ) and found extracellularly as a mature biologically active polypeptide . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the IL 1 beta converting enzyme ( ICE ) and its differential regulation and expression in brain and adrenals is also discussed . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Mouse pro IL 18 and pro IL 1 beta are processed by caspase 1 . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Biologic activity of IL 1 beta requires processing of the inactive precursor , a function generally ascribed to IL 1 beta converting enzyme ( caspase 1 ) . ^^^ Generation of biologically active IL 1 beta by matrix metalloproteinases : a novel caspase 1 independent pathway of IL 1 beta processing . ^^^ The present study indicates a biphasic regulation of IL 1 beta activity by MMPs : a caspase 1 independent pathway of IL 1 beta activation and inhibition of IL 1 beta activity by degrading the mature cytokine . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Since the precursor form of interleukin 1beta ( pre IL 1beta ) is one of the well known substrates for ICE , and a potassium / proton ionophore , nigericin , enhances IL 1beta processing , the authors hypothesized that nigericin induces apoptosis through the activation of ICE . ^^^ Under exactly the same conditions , nigericin also induced IL 1beta processing in these cells , which was significantly inhibited by an ICE inhibitor , acetyl Tyr Val Ala Asp CHO . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Together , these data suggest that CARDIAK may be involved in NF kappa B / JNK signaling and in the generation of the proinflammatory cytokine IL 1 beta through activation of caspase 1 . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The viral gene , called serp 2 , was cloned , and the Serp 2 protein was shown to specifically bind to interleukin 1beta ( IL 1beta ) converting enzyme ( ICE ) , thus inhibiting the cleavage of pro IL 1beta by the protease ( F . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We have cloned and sequenced a chicken homolog to the mammalian interleukin 1beta ( IL 1beta ) converting enzyme ( caspase 1 ) cDNA and have evaluated caspase 1 mRNA expression in various tissues from the domestic hen , including ovarian follicle granulosa and theca layers . ^^^ Finally , treatment of granulosa cells with IL 1beta , the primary if not sole product of caspase 1 activity , fails to either promote apoptotic cell death or enhance viability in granulosa cells . ^^^ Considering the relatively low levels of caspase 1 mRNA expression in ovarian follicle tissues plus the inability of IL 1beta to alter granulosa cell viability , in vitro , it is concluded that caspase 1 is not an integral part of the apoptotic pathway in granulosa cells . ^^^ However , the pattern of mRNA expression is consistent with a requirement for caspase 1 mediated IL 1beta production in chicken immune tissues . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Studies have shown that similar to the IL 1beta precursor , the IL 18 precursor requires cleavage into an active , mature molecule by the intracellular cysteine protease called IL 1beta converting enzyme ( ICE ) , which is also known as caspase 1 . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Here , we tested the hypothesis that NO regulates cytokine release by inhibiting IL 1beta converting enzyme ( ICE ) or caspase 1 activity . ^^^ Nitric oxide prevents IL 1beta and IFN gamma inducing factor ( IL 18 ) release from macrophages by inhibiting caspase 1 ( IL 1beta converting enzyme ) . ^^^ Procytokine processing by caspase 1 is required for the maturation and release of IL 1beta and IFN gamma inducing factor ( IGIF ) ( or IL 18 ) from activated macrophages ( Mphi ) . ^^^ The NO donor S nitroso N acetyl DL penicillamine inhibited caspase 1 activity in cells as well as the activity of purified recombinant caspase 1 and also prevented the cleavage of pro IL 1beta and pro IGIF by recombinant caspase 1 . ^^^ An in vivo role for the regulation of caspase 1 by NO was established in iNOS knockout animals , which exhibited significantly higher plasma levels of IL 1beta and IFN gamma than their wild type counterparts at 10 h following LPS injection . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 independent IL 1beta release and inflammation induced by the apoptosis inducer Fas ligand . ^^^ This IL 1beta secretion is independent of IL 1beta converting enzyme ( caspase 1 ) , yet it is inhibited by caspase inhibitors , indicating that a caspase ( s ) in addition to IL 1beta converting enzyme can process IL 1beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Culture of isolated islets from NMRI mice in the presence of interleukin 1beta ( IL 1beta ) induced the expression of ICE . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1beta ( IL 1beta ) mediates many of the behavioral responses to infection and inflammation , and IL 1beta converting enzyme ( ICE ) processes intracellular IL 1beta , leading to its maturation and secretion . ^^^ This defect occurred although ICE / mice were able to fully respond to intracerebroventricular injections of IL 1beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Stimulus coupled IL 1beta posttranslational processing , therefore , requires extracellular Na+ for a step downstream of the initiating stimulus but preceding caspase 1 activation . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Identification of the enzyme responsible for cleavage and activation of the IL 1beta precursor , the IL 1beta converting enzyme ( ICE ; caspase 1 ) , unexpectedly linked the IL 1 family to the apoptosis machinery , since ICE is the founding molecule of the caspase family , which is important for regulation of apoptosis . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Virus infection activates IL 1 beta and IL 18 production in human macrophages by a caspase 1 dependent pathway . ^^^ Since caspase 1 is known to cleave proIL 1 beta and proIL 18 into their mature , active forms , we analyzed the effect of a specific caspase 1 inhibitor on virus induced IL 1 beta and IL 18 production . ^^^ Furthermore , the virus induced activation of caspase 1 is required for the efficient production of biologically active IL 1 beta and IL 18 . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Although several enzymes associated with inflammatory tissues are capable of processing proIL 1 beta into an active molecule in the extracellular compartment , the IL 1 beta converting enzyme ( ICE , also called caspase 1 ) cuts intracellular proIL 1 beta after the aspartic acid residue in position 116 , resulting in a highly active mature IL 1 beta that is secreted into the extracellular space . ^^^ IL 18 is a member of the IL 1 family , and like IL 1 beta , proIL 18 is cleaved by ICE to yield an active molecule . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Among the possible molecular mechanisms are : ( a ) activation of proteases , as ICE ( Il 1 beta converting enzyme ) ; ( b ) calpain is activated in several cells , with PARP ( Poly ADP ribose polymerase ) and a small U 1 Ribonucleoprotein , being substrates for ICE and its homologs such as ICH and others proteins . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In addition , at 2 h after injection , TNFalpha , IL 1beta converting enzyme ( ICE ) , and IL 1 receptor antagonist ( IL 1RA ) mRNAs were induced in both anterior and posterior lobes . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Similar to IL 1beta , the precursor for IL 18 requires processing by caspase 1 . ^^^ In PBMCs , mature but not precursor IL 18 induces IFN gamma ; in whole human blood stimulated with endotoxin , inhibition of caspase 1 reduces IFN gamma production by an IL 1beta independent mechanism . ^^^ Western blotting of endotoxin stimulated PBMCs revealed processed IL 1beta in the supernatants via an caspase 1 dependent pathway . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In addition , expression of the mRNA of the IL 1beta converting enzyme ( ICE ) , which is essential to produce the mature form of IL 1beta , was constitutively observed in the HGF , suggesting that mature IL 1beta is produced by these cells . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In other systems , TNFalpha induced apoptosis is mediated by caspases , a growing family of cysteine proteases similar to the IL 1beta converting enzyme ( ICE ) , and so we have investigated whether NO NSAIDs modulate ICE like endopeptidases . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Neuronal expression of ICE and IL 1beta was seen in the lesion periphery 72 h and 7 days after injury . ^^^ The data indicate an early activation of microglia and monocyte invasion into the lesion hemisphere leading to multicellular expression of iNOS , ICE , and IL 1beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We have recently shown that IBD , but not normal , mucosal macrophages express the active form of IL 1beta converting enzyme ( ICE ) and are therefore capable of releasing mature IL 1beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 , or interleukin 1 beta converting enzyme ( ICE ) , promotes maturation of interleukin 1 beta ( IL 1 beta ) and interleukin 18 ( IL 18 ) by proteolytic cleavage of precursor forms to generate biologically active peptides . ^^^ Caspase 1 , or interleukin 1 beta converting enzyme ( ICE ) , promotes maturation of interleukin 1 beta ( IL 1 beta ) and interleukin 18 ( IL 18 ) by proteolytic cleavage of precursor forms to generate biologically active peptides . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta ( IL 1 beta ) converting enzyme ( ICE , caspase 1 ) processes the IL 1 beta precursor to mature inflammatory cytokine IL 1 beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Interleukin ( IL ) 1beta converting enzyme ( now known as caspase 1 ) is able to process pro IL 1beta into its active form and is involved in proapoptotic signalling . ^^^ CONCLUSIONS : The demonstration that the human colonic epithelial barrier is able to express caspase 1 and its substrate IL 1beta reinforces the concept that , under certain conditions , the epithelium could trigger an inflammatory reaction . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Significant increases in intrapancreatic mRNA levels of TNF alpha , Fas ligand ( FasL ) , and IL 1beta converting enzyme ( ICE ) were observed from day 3 after PDL with the appearance of acinar cell apoptosis . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To study the expression and production of interleukin 1beta converting enzyme ( ICE ) in human normal and osteoarthritic ( OA ) cartilage and synovium , quantitate the level of ICE in OA chondrocytes , and examine the relationship between the topographic distribution of ICE , interleukin 1beta ( IL 1beta ) , and IL 18 , as well as apoptosis of chondrocytes . ^^^ Furthermore , the topographic relationship between the presence of ICE and mature IL 1beta and IL 18 was examined by immunohistochemistry , and apoptotic chondrocytes by the TUNEL technique . ^^^ In cartilage , IL 1beta and IL 18 stained positive at a topographic location similar to that of ICE . ^^^ The production of mature IL 1beta in OA cartilage explants and chondrocytes was completely blocked by treatment with a specific ICE inhibitor , which also markedly diminished the number of IL 18 positive cells . ^^^ The relationship between active IL 1beta and ICE suggests that ICE may promote OA progression by activating this proinflammatory cytokine . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| To evaluate the involvement of IL 1 beta converting enzyme ( ICE ) in the autonomous AML cell growth , the effects of an antisense oligonucleotide on ICE were examined in 19 of these patients . ^^^ The presence of IL 1Ra or antisense ICE also suppressed the endogenous IL 1 beta production of AML cells , at both the level of pro IL 1 beta and mature IL 1 beta . ^^^ Although inhibition by IL 1Ra or antisense ICE on growth parameters of AML cells in vitro prevailed , indicating the importance of IL 1 activity in autonomous AML cell growth , stimulatory effects on the cells of some patients suggest that AML is a heterogenous disorder regarding IL 1 beta regulation . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Our results show that the induction of IL 1beta and IL 1 receptor antagonist proteins after kainic acid are closely associated with the temporal as well as the anatomical distribution of in situ end labelled neurons , whereas the induction of caspase 1 protein exhibited a delayed temporal profile and limited distribution . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In the presence of a specific inhibitor of caspase 1 ( also known as IL 1beta converting enzyme , or ICE ) IL 12 induced IFN gamma from splenocytes was reduced by 85 % . ^^^ However , the role of ICE was not through processing and release of IL 1beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Overexpression of IL 1ra gene up regulates interleukin 1beta converting enzyme ( ICE ) gene expression : possible mechanism underlying IL 1beta resistance of cancer cells . ^^^ An ICE inhibitor , Acetyl Tyr Val Ala Asp CHO ( YVAD CHO ) blocked IL 1beta induced growth inhibition in KU 1 and KU 2 . ^^^ These results suggest that IL 1beta sensitivity depends on the level of ICE gene expression , which is regulated by the level of endogenous slL 1ra expression . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 , formerly designated IL 1beta converting enzyme , is crucially involved in immune mediated inflammation because of its pivotal role in regulating the cellular export of IL 1beta and IL 18 . ^^^ Caspase 1 is transcriptionally induced during EAE , and its levels correlate with the clinical course and transcription rate of proinflammatory cytokines such as TNF alpha , IL 1beta , IFN gamma , and IL 6 . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NO mesalamine inhibited IL 1beta and IFN gamma release and caspase 1 activity in splenocytes ; such effects were not found in the inflamed colon . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 ( CASP 1 ) interleukin 1beta ( IL 1beta ) converting enzyme ( ICE ) has been cloned as a specific enzyme which activates the biologically inactive pro form of IL 1beta into biological active IL 1beta . ^^^ The plasma IL 1beta level of CASP 1 DNA injected mouse was elevated compared with that of the control DNA injected mouse . ^^^ These inflammatory reactions of CASP 1 DNA injected skin were suppressed by treatment with neutralizing anti murine IL 1beta antibodies , but the TUNEL positive apoptotic cells were still detected . ^^^ This study clearly demonstrate dual roles of CASP 1 in causing IL 1beta associated granulomatous skin infiltration and inducing apoptotic cell death in vivo . . ^^^ Caspase 1 ( CASP 1 ) interleukin 1beta ( IL 1beta ) converting enzyme ( ICE ) has been cloned as a specific enzyme which activates the biologically inactive pro form of IL 1beta into biological active IL 1beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Paradoxically , administration of IDN 1529 but not IDN 1965 led to an increase in the LPS induced elevation of serum cytokines related directly ( IL 1beta , IL 18 ) or indirectly ( IL 1alpha , IL 1Ra ) to the action of caspase 1 . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Expression of IL 1alpha and beta , IL 1 receptor antagonist ( IL 1Ra ) , IL 1RI and 2 , IL 1R accessory protein ( IL 1RAcP ) and IL 1beta converting enzyme ( ICE ) was studied by immunocytochemistry , immunoblotting , ELISA and RT PCR . ^^^ Human normal myogenic cells constitutively produced IL 1beta and ICE , with a maximum expression at time of cell fusion . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We report here that a cancer gene therapy protocol using a combination of IL 12 , pro IL 18 , and IL 1beta converting enzyme ( ICE ) cDNA expression vectors simultaneously delivered via gene gun can significantly augment antitumor effects , evidently by generating increased levels of bioactive IL 18 and consequently IFN gamma . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Specifically , mice that were deficient in ICE ( ICE ( / ) ) resisted the anorexia caused by intracerebroventricular injection of LPS but were sensitive to the anorectic properties of recombinant IL 1beta . ^^^ Thus ICE mRNA is expressed in brain after intracerebroventricular injection of LPS and is important for induction of anorexia , presumably because it generates mature IL 1beta . ^^^ These results suggest that preventing generation of mature IL 1beta can inhibit anorexia induced by LPS in the brain and , therefore , reveal ICE as a potential target for regulating food intake during brain inflammation . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Therefore , expression analysis performed by Northern blotting and immunohistochemistry were extended to include IFN gamma , the IFN gamma receptor beta subunit ( IFN gammaRbeta ) , three secondary response genes induced by interaction of IFN gamma with IFN gamma receptor complexes , ie , IL 1beta converting enzyme ( ICE ) , intercellular adhesion molecule 1 ( ICAM 1 ) , and urokinase type plasminogen activator receptor ( uPAR ) , and a cytokine inducing IFN gamma expression , ie , interleukin 18 ( IL 18 ) . ^^^ In contrast , during liver regeneration after a 70 % partial hepatectomy , only modulation of IL 1beta and ICE was observed . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Also similar to IL 1beta , IL 18 is synthesized as a biologically inactive precursor molecule lacking a signal peptide which requires cleavage into an active , mature molecule by the intracellular cysteine protease called IL 1beta converting enzyme ( ICE , also called caspase 1 ) . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 ( IL 1 ) converting enzyme ( ICE ) is a cysteine protease that cleaves inactive pro IL 1beta to active IL 1beta . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The authors ' results indicate that TNF alpha expression is increased in both ICE KO and wild type mice suggesting that TNF alpha expression is not related to or upregulated by IL 1beta . ^^^ ICAM 1 expression is significantly reduced in the ICE KO mice suggesting that IL 1beta plays an important role in the upregulation of adhesion molecules during focal cerebral ischemia . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In this study , hepatic metastasis after intrasplenically injected mouse B 16 melanoma ( B16M ) cells was reduced 84 95 % in mice with null mutations for either IL 1beta or the IL 1beta converting enzyme ( ICE , caspase 1 ) compared with wild type mice . ^^^ On day 12 , 47 % of wild type mice were dead compared with 19 % of either IL 1beta or ICE deficient mice . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Treatment with IL 1beta was associated with a small but statistically insignificant increase in ovarian ICE gene expression . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The inhibition of apoptosis was accompanied by downregulation of apoptosis promoting proteases , including interleukin 1beta converting enzyme ( ICE ) and CPP 32 and upregulation of anti apoptotic cytokine ( interleukin 1beta ( IL 1beta ) ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We have cloned and sequenced a cDNA that contains the coding sequence of porcine interleukin 1beta ( IL 1beta ) converting enzyme ( ICE ) . ^^^ The kinetics of mRNA expression of ICE , IL 1beta , and IL 18 in porcine alveolar macrophages after LPS stimulation revealed that ICE transcripts were weakly expressed in nonstimulated condition and upregulated after LPS stimulation . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In addition to the well established role of caspase 1 in the production of active IL 1beta and IL 18 in inflammation , 4 an increasing number of reports has recently suggested that caspases may have a function outside of apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Mechanisms that regulate conversion of prointerleukin 1beta ( pro IL 1beta ) to its mature form by the cysteine protease caspase 1 are not well understood . ^^^ In this study , we demonstrate that mature caspase 1 subunits are produced when human monocytes are treated with ATP and , like mature IL 1beta , are released extracellularly . ^^^ Characterization of the pharmacological sensitivity of this stimulus coupled response revealed that some caspase 1 inhibitors allow pro IL 1beta secretion , whereas others do not . ^^^ Two inhibitors of anion transport , glyburide and ethacrynic acid , blocked maturation of both caspase 1 and pro IL 1beta and prevented release of the propolypeptides . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The inhibition of IL 1beta production by 1 involved a post translational mechanism of action at the level of IL 1beta secretion as demonstrated by the lack of an effect on cell associated IL 1beta production . 1 showed no effect on the activity of caspase 1 in cytosolic extracts from the THP 1 monocytic cell line . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Here we tested the hypothesis that the above stimuli act via a mechanism involving cleavage of the IL 1beta precursor by interleukin 1beta converting enzyme ( ICE , also referred to as caspase 1 ) . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Accordingly , in ATP stimulated microglia , the p 20 proteolytic fragment derived from activation of the IL 1 beta converting enzyme could be detected by immunoblot analysis . ^^^ These experiments show that in mouse microglial cells extracellular ATP triggers fast maturation and release of intracellularly accumulated IL beta by activating the IL 1 beta converting enzyme / caspase 1 . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We report here that the serine proteinase inhibitor ( serpin ) PI 9 accounts for the endogenous caspase 1 inhibitory activity in human SMCs and prevents processing of the enzyme ' s natural substrates , IL 1beta and IL 18 precursor . ^^^ In human atherosclerotic lesions , however , PI 9 expression correlated inversely with immunoreactive IL 1beta , supporting a potential role of the endogenous caspase 1 inhibitor in this chronic inflammatory disease . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1beta converting enzyme ( ICE ) deficient mice , lacking the ability to process mature IL 18 and IL 1beta , were completely resistant to lethal endotoxemia induced by LPS derived from either Escherichia coli or Salmonella typhimurium . ^^^ In contrast , both wild type and IL 1beta / mice were equally susceptible to the lethal effects of LPS , implicating that absence of mature IL 18 or IFN gamma but not IL 1beta in ICE / mice is responsible for this resistance . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| ICE messenger RNA ( mRNA ) expression was highly up regulated after 6 , 24 , and 72 h exposure of human islets to interferon ( IFN ) gamma , tumor necrosis factor ( TNF ) alpha + IFNgamma or IL 1beta + TNFalpha + IFNgamma , paralleled by increased iNOS ( the inducible form of NO synthase ) expression and NO production after exposure to the combined cytokines but not to IFNgamma or TNFalpha + IFNgamma . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1beta and ICE mRNA are not altered upon beta amyloid ( 25 35 ) induced neurotoxicity in human neuroblastoma cells . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Suppression of the expression of caspase 1 mRNA , which is known to be an IL 1beta converting enzyme and which also cleaves the precursor of IL 18 , was observed in the SAC stimulated PBMCs from healthy individuals after treatment with TGF beta 1 and in the SAC stimulated PBMCs from HIV 1 seropositive hemophiliacs , suggesting that the decreased production of IL 18 and IL 1beta in HIV 1 seropositive hemophiliacs may be related to the downregulation of caspase 1 mRNA induced by high levels of TGF beta 1 in plasma . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In the present study , we have analyzed the temporal profile of the expression of the cytokines interleukin 1beta ( IL 1beta ) and IL 1 receptor antagonist ( IL 1ra ) , and the related IL 1beta converting enzyme ( ICE / caspase 1 ) , in different regions of the rat brain in response to peripheral kainic acid administration ( 10 mg / kg , i . p . ) . ^^^ In conclusion , in response to systemic kainic acid injection IL 1beta mRNA is rapidly induced and followed by induction of IL 1ra mRNA and caspase 1 mRNA , supporting a role of the IL 1 system in the inflammatory response during excitotoxic damage . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We report that potassium leakage from cells leads to activation of the Ca2+ independent phospholipase A 2 ( iPLA 2 ) , and the latter plays a pivotal role in regulating the cleavage of pro IL 1 beta by the IL converting enzyme caspase 1 in human monocytes . ^^^ Bromoenol lactone dependent inhibition of IL 1 beta processing was not due to perturbation of the export machinery for pro IL 1 beta and IL 1 beta or to caspase 1 suppression . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| It lacks a signal peptide in common with other known IL 1B genes , and lacks a clear ICE ( caspase ) cut site in common with other nonmammalian IL 1B genes sequenced to date . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Structural comparison of the IL 18 protein with IL 1alpha and IL 1beta showed that IL 18 shares several characteristics with the IL 1 cytokine family : the IL 1 signature like sequence , a potential caspase 1 ( ICE ) cleavage site , and the presence of 12 predicted beta strands . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Although , the exact mechanism of IL 18 secretion is not confirmed , it seems that , like IL 1beta , IGIF is processed by the cysteine proteases belonging to caspase family , especially by ICE ( interleukin 1beta converting enzyme ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Diacerhein and rhein reduce the ICE induced IL 1beta and IL 18 activation in human osteoarthritic cartilage . ^^^ As the interleukin 1 converting enzyme ( ICE ) is the physiologic modulator of the production of active IL 1beta , we investigated the effect of diacerhein and its active metabolite rhein used in the treatment of OA patients , on the enzyme expression and synthesis on human OA cartilage . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Mature IL 1beta derives from a 31 kD precursor ( pro IL 1beta ) that is processed by IL 1beta converting enzyme ( ICE ) . ^^^ Mice in which the ICE gene has been nullated by homologous recombination were used to investigate the role of IL 1beta in the HPA axis response . ^^^ In contrast , plasma ACTH response to restraint or to 200 ng of rat recombinant IL 1beta ( rrIL 1beta ) was higher in ICE deficient mice as compared to WT animals . ^^^ This hyperreactivity of the HPA axis in ICE knockout mice appears not to be related to the production of plasma IL 1beta or IL 6 , which was similar to that of WT mice after rrIL 1beta injection . ^^^ After lipopolysaccharide , ICE deficient mice exhibited a smaller increase in plasma immunoreactive IL 1beta and IL 6 as compared to WT controls . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The ICE subfamily of caspases comprise peptides closely related to caspase 1 , or interleukin 1beta ( IL 1beta ) converting enzyme ( ICE ) , which promotes maturation of interleukin IL 1beta and interleukin 18 ( IL 18 ) by proteolytic cleavage of precursor forms to generate biologically active peptides . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Shigella flexneri , the etiological agent of bacillary dysentery , induces macrophage apoptosis , which requires Casp 1 and results in the release of mature IL 1beta and IL 18 . ^^^ Using casp 1 ( / ) mice supplemented with recombinant cytokines and experiments with IL 1beta ( / ) and IL 18 ( / ) mice , we show that IL 1beta and IL 18 are both required to mediate inflammation in S . flexneri infections . ^^^ Together , these data demonstrate the importance of Casp 1 in acute inflammation and show the different roles of its substrates , IL 1beta and IL 18 , in this response . . ^^^ Caspase 1 activation of IL 1beta and IL 18 are essential for Shigella flexneri induced inflammation . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1beta converting enzyme ( ICE ) inhibitors do not prevent the recovery of IL 1beta bioactivity after allorecognition , indicating that allospecific CD 8 ( + ) T cells may induce the release of bioactive IL 1beta via mechanism ( s ) other than ICE activation . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We report that intraperitoneal injection of lipopolysaccharide increased hippocampal caspase 1 activity and IL 1beta concentration ; these changes were associated with increased activity of the stress activated kinase c Jun NH ( 2 ) terminal kinase , decreased glutamate release , and impaired long term potentiation . ^^^ Inhibition of caspase 1 blocked these changes , suggesting that IL 1beta mediated the lipopolysaccharide induced changes . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The levels of the precursor , p 45 , and the active subunit p 10 peptides of the IL 18 processing enzyme , IL 1beta converting enzyme ( ICE ) , showed no substantial differences in all the conditions tested . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| To study the pathophysiological roles of overexpressed caspase 1 ( CASP 1 ) , originally designated as IL 1 beta converting enzyme , we generated transgenic mice in which human CASP 1 is overexpressed in their keratinocytes . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interestingly , BLP also activates caspase 1 through TLR 2 , resulting in proteolysis and secretion of mature IL 1beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Casp 1 is unique among caspases because it also directly cleaves the proinflammatory cytokines IL 1beta and IL 18 to produce bioactive cytokines . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the correlation of gut epithelial cell apoptosis with ICE , IL 1 beta gene expression in septic mice . ^^^ IL 1 beta , ICE gene expression was detected quantitatively by RT PCR . ^^^ IL 1 beta , ICE mRNA expression in CLP mice was significantly higher than that in the sham operation group ( P < 0 . 01 ) ; IL 1 beta mRNA expression was parallel to ICE mRNA expression . ^^^ The number of epithelial cell apoptosis was correlated excellently to the level of ICE , IL 1 beta mRNA expression . ^^^ CONCLUSION : ICE , IL 1 beta gene overexpression may be involved in the vulnerability of epithelial cell apoptosis in septic mice . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The molecular machinery at the nexus of apoptosis and inflammation includes caspase 1 an activator of IL 1beta and IL 18 as well as the double stranded RNA dependent protein kinase pathway and RNaseL pathway , which are key effectors of antiviral immunity . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The effect of acetyl tyrosyl valyl alanyl aspartyl chloromethylketone ( ac YVAD cmk ) , an irreversible caspase 1 ( IL 1beta converting enzyme , ICE ) inhibitor on mortality , leukocyte and platelet counts and cytokine levels was investigated in a double blind rat model of endotoxaemia . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In response to ATP , however , pro IL 1 beta produced by the P2X ( 7 ) R ( / ) cells is not externalized or activated by caspase 1 . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| These precursors are cleaved by caspase 1 ( IL 1beta converting enzyme , ICE ) to form the biologically active mature cytokines . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 , the IL 1beta converting enzyme ( ICE ) , is required for intracellular processing / maturation of IL 1beta and IL 18 . ^^^ IL 1 beta converting enzyme is a target for nitric oxide releasing aspirin : new insights in the antiinflammatory mechanism of nitric oxide releasing nonsteroidal antiinflammatory drugs . ^^^ Caspase 1 , the IL 1beta converting enzyme ( ICE ) , is required for intracellular processing / maturation of IL 1beta and IL 18 . ^^^ Taken together , these data indicate that incubating human monocytes with NCX 4016 causes intracellular NO formation and suppresses IL 1beta and IL 18 processing by inhibiting caspase 1 activity . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The critical role of amoebic cysteine proteinases in human gut inflammation and tissue damage may be explained by our discovery that amoebic cysteine proteinases possess IL 1B converting enzyme ( ICE ) activity . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The intracellular and supernatant protein amounts of IL 1alpha , the precursor and mature forms of IL 1beta , IL 1 receptor antagonist ( IL 1 RA ) , and the intracellular level of IL 1beta converting enzyme ( ICE ) were measured with enzyme linked immunosorbent assays ( ELISAs ) . ^^^ Western blot analysis was performed to evaluate IL 1 RA protein . mRNA steady state amounts were determined by RNase protection assay ( RPA ) for IL 1alpha , IL 1beta , IL 1 RA , and ICE . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 , formerly designated interleukin 1beta ( IL 1beta ) converting enzyme , processes pro IL 1beta and pro IL 18 to yield active cytokines that play a pivotal role in inflammation and cell activation . ^^^ Early in infection , production of these cytokines and that of tumor necrosis factor alpha , IL 6 , and , interestingly , IL 1beta occurred normally in caspase 1 deficient mice , while that of IL 18 was severely impaired . ^^^ We conclude that , while caspase 1 is not indispensable for release of mature IL 1beta in candidiasis , the caspase 1 dependent production of IL 18 may represent an important and novel pathway for the expression of sustained Th 1 reactivity to the fungus . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| As with other nonmammalian IL 1beta genes , no interleukin converting enzyme ( ICE ) cut site has been found but the alignment of the amino acid sequence with other species shows a possible cut site between Arg 89 and Ala 90 that would give arise to a 165 amino acid mature peptide . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Gene expression of mRNA for IL 1alpha , IL 1beta , IL 1 receptor antagonist ( IL 1ra ) , type 1 IL 1 receptor , type 2 IL 1 receptor , and IL 1 beta converting enzyme ( ICE ) , were measured by a semi quantitative RT PCR technique . ^^^ Incubation of MNCs with LPS resulted in up regulation of IL 1beta , IL 1ra , and type 2 IL 1R , no change in IL 1alpha , and a decrease in ICE gene expression . ^^^ Incubation of PMNs with LPS up regulated IL 1beta gene expression , whereas , IL 1alpha , IL 1ra , type 2 IL 1R and ICE were unchanged . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Inhibition of interleukin 1beta ( IL 1beta ) production in human cells by ribozymes against IL 1beta and IL 1beta converting enzyme ( ICE ) . ^^^ This empirical selection study , which used interleukin 1beta ( IL 1beta ) and IL 1beta converting enzyme ( ICE ) as example targets , resulted in ( 1 ) the rapid identification of ribozymes that can reduce the production of IL 1beta in THP 1 cultures by 10 fold and ( 2 ) the consequent direct generation of stable knockdown cell lines . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Both the Fas Receptor ( Fas R ) and interleukin 1beta ( IL 1beta ) converting enzyme ( ICE ; caspase 1 ) appear to play a role in the mechanism of apoptosis of CD 4 ( + ) lymphocytes . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| They were first studied in mice deficient for the IL 1 beta converting enzyme ( ICE ) gene . ^^^ Mature IL 1 beta derives from a precursor , the pro IL 1 beta , devoid of any conventional signal sequence that is mainly processed by ICE . ^^^ After immune or stress stimulation , ICE deficient mice were shown to have a hyperactive HPA axis and to able to produce immunoreactive IL 1 beta . ^^^ This indicates that the greater reactivity of the HPA axis could result from a higher sensitivity to non ICE matured IL 1 beta , as suggested by a higher basal transcription of hypothalamic IL 1 receptor type 1 ( IL 1 RI ) in ICE deficient mice . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| ICEBERG is a novel protein that inhibits generation of IL 1beta by interacting with caspase 1 and preventing its association with RIP 2 . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The production of bio active interleukin 1beta ( IL 1beta ) , a pro inflammatory cytokine , is mediated by activated caspase 1 . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Whereas intrapancreatic IL 1beta mRNA expression was highly up regulated in both treated and untreated animals , active IL 1beta protein expression and subsequent neutrophil tissue infiltration was dramatically decreased in the ICE inhibited group . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Elevation of mitochondrial immunoreactive IL 1beta levels seems to originate from the conversion operated by the interleukin converting enzyme ( ICE ) of mitochondrial pro IL 1beta ; in fact , IL 1beta increases reported in the ELISA experiments were paralleled by a decrease of the mitochondrial pro IL 1beta 31 kDa band in conjunction with enhanced expression of the p 20 component of activated ICE . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Data presented suggest that LL Z1271alpha inhibits IL 1beta production by a novel mechanism as the inhibitory activity was not due to effects on caspase 1 ( IL 1beta converting enzyme ) , the ATP induced release mechanism or a lysosomotrophic effect . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Different doses of caspase 1 ( IL 1beta converting enzyme ) and caspase 3 inhibitors ( Ac DEVD cmk ) were added to the medium at the time of serum withdrawal , and the ability of the inhibitors to promote dopaminergic neuronal survival and prevent activation of caspase 3 was assessed at 7 days . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Regulation of IL 1beta generation by Pseudo ICE and ICEBERG , two dominant negative caspase recruitment domain proteins . ^^^ Our data suggest that Pseudo ICE and ICEBERG are intracellular regulators of caspase 1 activation and could play a role in the regulation of IL 1beta secretion and NF kappaB activation during the pro inflammatory cytokine response . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Blockade of the IL 1beta converting enzyme ( ICE ) by Tyr Val Ala Asp aldehyde ( YVAD CHO ) decreased the levels of mature IL 1beta but had no effect on pro IL 1beta . ^^^ Release of pro IL 1beta was not associated with cell death nor with the extracellular release of ICE . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Analysis of mRNA expression revealed that lpr / lpr PMN have reduced expression of IL 18 , whereas IL 1beta , IFNgamma , caspase 1 and caspase 3 are expressed at levels comparable to those of + / + cells . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| METHODS : Pulse chase labeling followed by immunoprecipitation of IL 1beta in activated human monocyte lysates demonstrated sequential cutting by ICE at site 1 before site 2 in vitro . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1 beta converting enzyme ( ICE ; caspase 1 ) is the intracellular protease that cleaves the precursors of IL 1 beta and IL 18 into active cytokines . ^^^ IL 1 beta converting enzyme ( caspase 1 ) in intestinal inflammation . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Results obtained by studying mice deficient for IL 1alpha , IL 1beta , IL 1 receptor antagonist , IL 1 receptor type 1 , IL 1 receptor accessory protein , IL 1 receptor associated kinase , and the IL 1beta converting enzyme caspase 1 are summarized . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| A unique downstream estrogen responsive unit mediates estrogen induction of proteinase inhibitor 9 , a cellular inhibitor of IL 1beta converting enzyme ( caspase 1 ) . ^^^ Recently , proteinase inhibitor 9 ( PI 9 ) was identified as the first endogenous inhibitor of caspase 1 ( IL 1beta converting enzyme ) . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| ELISA experiments have established that gp 120 enhances immunoreactive IL 1beta levels in the culture medium and this is prevented by exposure to the IL 1 converting enzyme ( ICE ) inhibitor t butoxycarbonyl L aspartic acid benzyl ester chloromethylketone [ Boc Asp ( OBzl ) CMK ] used at a concentration ( 2 . 5 microM ) which significantly ( P < 0 . 001 ) reduces cell death . 4 . ^^^ Death of CHP 100 cells induced by gp 120 is also prevented by acetyl Tyr Val Ala Asp chloromethylketone ( Ac YVAD CMK ; 10 100 microM ) , a second inhibitor of ICE , supporting the concept that the viral protein stimulates the conversion of the 31 kDa pro IL 1beta in to the 17 kDa mature cytokine which is then secreted to cause death . 5 . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Activation of this receptor in bacterial lipopolysaccharide ( LPS ) activated macrophages or monocytes also stimulates processing and release of the cytokine interleukin 1beta ( IL 1beta ) through activation of caspase 1 . ^^^ The cytokine interleukin 18 ( IL 18 ) is also cleaved by caspase 1 and shares pro inflammatory characteristics with IL 1beta . ^^^ The objective of the present study was to test the hypothesis that IL 1beta , IL 18 , and / or caspase 1 activation contribute directly to macrophage cell death induced by LPS and ATP . ^^^ Macrophages were cultured from normal mice or those in which genes for the P2X7 receptor , IL 1beta , IL 1alpha , IL 18 , or caspase 1 had been deleted . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The two known substrates of activated caspase 1 are the pro inflammatory cytokines interleukin 1beta ( IL 1beta ) and IL 18 , which are cleaved to produce bioactive cytokines . ^^^ Thus , both rapid , SPI 1 mediated killing and delayed , SPI 2 mediated killing require caspase 1 and result in the secretion of IL 1beta , which promotes inflammation and may facilitate the spread of Salmonella beyond the gastrointestinal tract in systemic disease . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Role of CD 95 activated caspase 1 processing of IL 1beta in TCR mediated proliferation of HIV infected CD 4 ( + ) T cells . ^^^ Proliferation of CD 4 ( + ) T cells induced by CD 3 TCR and CD 95 costimulation was decreased by treatments with a caspase 1 inhibitor or with neutralizing antibodies to IL 1ss , indicating a requirement for caspase 1 mediated IL 1beta processing and secretion . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 ( IL 1 ) beta ( IL 1beta ) converting enzyme ( ICE ) is a cysteine protease ( caspase 1 ) that processes inactive ( 33 kDa ) pro IL 1beta to the active ( 17 kDa ) inflammatory cytokine . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Activation of the IL 1beta and IL 18 precursors is performed enzymatically by caspase 1 , previously termed IL 1beta converting enzyme ( ICE ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Reducing IL 1beta and IL 18 production by inhibition of IL 1beta converting enzyme ( ICE , caspase 1 ) is one promising strategy because of the key roles of these cytokines in many inflammatory diseases . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that CARD 8 interacts physically with caspase 1 and negatively regulates caspase 1 dependent IL 1beta generation in the THP 1 monocytic cell line . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The vaccinia encoded protein ( CrmA ) is known to inhibit caspase 1 ( ICE protease ) that converts inactive IL 1beta to an active secreted form . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Similarly to IL 1beta , IL 18 is synthesized as a precursor requiring caspase 1 for cleavage into an active IL 18 molecule . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 18 is synthesized as an inactive precursor , pro IL 18 , which is cleaved by IL 1beta converting enzyme ( ICE ) / caspase 1 in a mature protein . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 plays a pivotal role in immune mediated inflammation , as it regulates the cellular export of IL 1beta and IL 18 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Shigella flexneri infection of macrophages ( MPhi ) leads to activation of caspase 1 by the IpaB virulence factor , which induces rapid cell death and release of mature IL 1beta . ^^^ Cytotoxicity is also partially blocked by glycine without affecting caspase 1 dependent IL 1beta processing , and treatment with glycine and YVAD completely blocks cytotoxicity , implying that glycine inhibits a caspase 1 independent cytotoxic mechanism . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Normally , IL 18 is translated as a precursor form of a 24kDa polypeptide and processed by IL 1beta converting enzyme ( ICE ) to a mature bioactive form of 18kDa protein . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 18 and IL 1beta are cleaved and thereby activated by the interleukin 1beta converting enzyme ( ICE ) . ^^^ Activation of ICE also occurs during different types of infectious colitis , and ICE expression and subsequent release of IL 1beta and IL 18 significantly contribute to intestinal inflammation . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In the lining like layers and deep stroma of SMLIT , many cells were double positive for active caspase 1 and interleukin 1 beta ( IL 1beta ) . ^^^ Caspase 1 can be involved in implant loosening by processing IL 1beta precursor into its mature form , which is a potent osteoclast activating factor and a major proinflammatory mediator . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Since the release of IL 1beta in LPS stimulated whole blood was blocked by the caspase 1 inhibitor YVAD cmk , processing of proIL 1beta appears to depend on caspase 1 activity . ^^^ The conclusion that G CSF inhibits caspase 1 activity was supported bythe finding that the release of IL 18 was also inhibited by G CSF , similar to IL 1beta release . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Our aim was to characterize the expression of IL 18 and its receptor in relation to caspase 1 and IL 1beta after HI and to evaluate to what extent IL 18 contributes to HI brain injury . ^^^ The mRNA for IL 18 and caspase 1 were analyzed with reverse transcriptase PCR , protein was analyzed by Western blot ( IL 18 , caspase 1 ) or ELISA ( IL 1beta ) , and the regional distribution was assessed by immunohistochemistry . ^^^ The expression of mRNA / protein for caspase 1 and IL 18 in brain homogenates increased progressively at 12 hr to 14 d after HI , whereas IL 1beta peaked at 8 hr . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| It acquires activity after secretion when cleaved with a specific intracellular protease , IL 1beta converting enzyme ( ICE ) . ^^^ ICE deficient animals display impaired production of IL 1beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Proteinase inhibitor 9 ( PI 9 ) inhibits caspase 1 ( interleukin ( IL ) 1beta converting enzyme ) and granzyme B , thereby regulating production of the pro inflammatory cytokine IL 1beta and susceptibility to granzyme B induced apoptosis . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Murine caspase 11 , together with caspase 1 , is essential for the production of IL 1beta in response to lipopolysaccharide ( LPS ) . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The early activation of caspases 3 / 7 by caspase 11 was not affected by blocking of caspase 1 activity and IL 1beta release , implying that caspase 11 activates caspases 3 / 7 independently of caspase 1 activation . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In parallel , a strong increase in endothelial interleukin ( IL ) 1beta converting enzyme ( ICE ) and IL 1beta expression and activity was observed . ^^^ Specific inhibition of ICE activity or IL 1beta functionality significantly reduces expression and activity of the iNOS to control values . ^^^ Because ICE activity is essential for the endogenous synthesis of active IL 1beta , ICE overexpression represents the key signal in the AmB induced and IL 1beta mediated effects on iNOS activity . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , this mRNA expression did not translate into intracellular accumulation of IL 1beta or IL 18 precursor proteins or secretion of mature cytokines , despite the presence of detectable caspase 1 activity in these cells . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 , the prototypic caspase , is known to process the cytokines IL 1beta and IL 18 to mature forms but it is unclear whether , like other caspases , it can induce apoptosis by activation of downstream protease cascades . ^^^ Neutrophils are known to express caspase 1 , to release IL 1beta and to undergo rapid , caspase dependent apoptosis . ^^^ We examined apoptosis and IL 1beta production in peripheral blood neutrophils of caspase 1 deficient and wild type mice . ^^^ LPS stimulated IL 1beta production was absent from caspase 1 deficient neutrophils . ^^^ IL 1beta production was increased in wild type lungs but was also detected in caspase 1 deficient mice . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The production of bioactive interleukin 1beta ( IL 1beta ) , a pro inflammatory cytokine , is mediated by activated caspase 1 . ^^^ Because Nod 1 also binds to RIP 2 , we hypothesized that Nod 1 plays a role in pro caspase 1 activation and IL 1beta processing . ^^^ Nod 1 enhances caspase 1 induced IL 1beta secretion , as well as lipopolysaccharide ( LPS ) induced IL 1beta secretion in transfected cells . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The LPS induced effects were abrogated by inhibition of caspase 1 , suggesting that IL 1 beta may mediate the effects of LPS . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| These Pw induced changes were accompanied by an increase in caspase 1 and interleukin 1beta ( IL 1beta ) , and were associated with increased activity of the stress activated kinase , p 38 . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Stimulus induced posttranslational processing of human monocyte interleukin 1beta ( IL 1beta ) is accompanied by major changes to the intracellular ionic environment , activation of caspase 1 , and cell death . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Using primary cultured murine peritoneal macrophages , we demonstrate that P2X7 receptor activation causes release of IL 1 beta and IL 1 alpha via a common pathway , dependent upon the release of Ca ( 2+ ) from endoplasmic reticulum stores and caspase 1 activity . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| It is also partially mediated by interleukin 1beta ( IL 1beta ) converting enzyme ( ICE ; caspase 1 ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Moreover , reduction in extracellular Ca2+ attenuates approximately 90 % of P2X7 receptor mediated IL 1beta secretion but has no effect on enzymatic processing of precursor IL 1beta ( proIL 1beta ) to mIL 1beta by caspase 1 . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| When stimulated , macrophages from these mice produce increased amounts of activated caspase 1 and , consequently , elevated levels of mature IL 1beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Inhibition of caspase 1 reduced IFN gamma and IL 1beta levels ( by 80 and 67 % , respectively ) when heat killed S . epidermidis was added to whole human blood cultures . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 is involved in the activation of both apoptosis and inflammation , through the intermediate of interleukin 1beta ( IL 1beta ) . ^^^ Ac YVAD . cmk treatment resulted in a reduction not only of IL 1beta and caspase 1 , but also of caspase 3 in the ischaemic myocardium in both normally fed and cholesterol fed rabbits . 7 . ^^^ No differences in infarct size , the percentage of TUNEL positive cardiomyocytes , IL 1beta levels or activity of caspase 1 and caspase 3 were observed between Ac YVAD . cmk treated normally fed and cholesterol fed rabbits . 8 . ^^^ This study demonstrates that injection of a selective caspase 1 inhibitor after myocardial ischaemia markedly reduced the detrimental effect conferred by hypercholesterolaemia on myocardial ischaemia reperfusion injury by attenuating both necrotic as well as apoptotic cell death pathways through inhibition of IL 1beta production and activation of caspase 1 and caspase 3 . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| METHODS : Immunohistochemical staining of skeletal muscle biopsies ( 10 DM , 10 SSc , 10 PM , 10 SLE , 10 non inflammatory myopathies ) for tumour necrosis factor alpha ( TNF alpha ) , interleukin 1 beta ( IL 1 beta ) , activated caspase 1 , pan macrophage marker CD 68 , inducible nitric oxide synthase ( NOS 2 ) and nerve growth factor receptor ( NGFR ) . ^^^ RESULTS : Expression of TNF alpha , IL 1 beta , caspase 1 and NOS 2 was found in the cytoplasm and sarcolemma of dystrophic skeletal muscle fibres . ^^^ CONCLUSION : Prominent expression of the proinflammatory factors TNF alpha , IL 1 beta and NOS 2 and caspase 1 is associated with muscle fibre damage , albeit when expressed to a low degree these factors may , like NGFR , contribute to muscle regeneration and healing . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| As previously reported , transgenic mice ( KCASP1Tg ) , that over express caspase 1 in their KC , display high serum levels of IgE , and spontaneously develop chronic dermatitis by production of IL 18 and IL 1beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| While statins may stimulate the secretion of caspase 1 , IL 1beta and IL 18 in peripheral mononuclear cells in response to Mycobacterium tuberculosis , they exhibit additional effects on inflammation by decreasing IL 6 synthesis in human vascular smooth muscle cells ( VSMC ) in vitro . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Release and cleavage of active IL 1 beta may be achieved via purinergic P2X7 receptors and activation of caspase 1 . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We present evidence suggesting that interleukin ( IL ) 1beta plays a significant role in mediating the effects of Abeta ( 1 40 ) because Abeta ( 1 40 ) increased hippocampal IL 1beta and because several effects of Abeta ( 1 40 ) were inhibited by the caspase 1 inhibitor Ac YVAD CMK . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Changes in caspase 3 and caspase 1 , interleukin 1 beta ( IL 1 beta ) , and collagen 1 , 3 , and 4 proteins and mRNA were detected by Western blotting and Northern blotting , respectively . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Mice with targeted deletion of caspase 1 ( interleukin 1beta ( IL 1beta ) converting enzyme ) lack the active forms of IL 1beta and IL 18 , two cytokines implicated in maladaptive ventricular remodeling following cardiac injury . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Although IL 12 is also an IFN gamma inducing factor , the activity of IL 18 ( but not IL 12 ) in models of sepsis and death is dependent on the intracellular cysteine protease IL 1beta converting enzyme ( caspase 1 ) . ^^^ The absence of IFN gamma ( but not IL 1beta ) in caspase 1 deficient mice is responsible for this resistance . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1beta converting enzyme ( ICE ) , the caspase responsible for the maturation of pro IL 1beta in IL 1beta , was activated by P2X7 receptor stimulation . ^^^ The specific inhibition of ICE by the caspase inhibitor Ac Tyr Val Ala Asp aldehyde blocked the maturation of IL 1beta . ^^^ In searching for a link between the P2X7 receptor and the activation of ICE , we found that enhancing potassium efflux from Schwann cells upregulated the production of IL 1beta , while strongly reducing potassium efflux led to opposite effects . ^^^ Taken together , these results show that P2X7 receptor stimulation and associated BK channels , through the activation of ICE , leads to the maturation and the release of IL 1beta by immune challenged Schwann cells . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Inflammatory stimuli induce and activate caspase 11 , which is required for the activation of caspase 1 or interleukin 1beta ( IL 1beta ) converting enzyme ( ICE ) . ^^^ Caspase 1 in turn mediates the maturation of proinflammatory cytokines such as IL 1beta , which is one of the crucial mediators of neurodegeneration in the central nervous system . ^^^ Here , we report that hypoxic exposure of cultured brain microglia ( BV 2 mouse microglia cells and rat primary microglial cultures ) induces expression and activation of caspase 11 , which is accompanied by activation of caspase 1 and secretion of mature IL 1beta and IL 18 . ^^^ Taken together , our results indicate that hypoxia induces a sequential event caspase 11 induction , caspase 1 activation , and IL 1beta release in brain microglia , and point out the importance of initial caspase 11 induction in hypoxia induced inflammatory activation of microglia . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In the present study we confirm that Fas signaling induces both phenotypic and functional maturation of murine DCs , and we demonstrate that phenotypic maturation is associated with phosphorylation of extracellular signal regulated kinase ( ERK ) 1 / 2 , activation of caspase 1 , and secretion of interleukin beta ( IL 1beta ) . ^^^ Specific inhibition of ERK1 / 2 diminished Fas ligation induced caspase 1 activation , IL 1beta secretion , and ensuing up regulation of developmental markers , whereas treatment with neutralizing anti IL 1beta antibody abrogated phenotypic and functional maturation , indicating that IL 1beta mediates Fas ligation induced DC maturation in an autocrine manner . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The potassium ionophore nigericin induces cell death and promotes the maturation and release of IL 1beta in lipopolysaccharide ( LPS ) primed monocytes and macrophages , the latter depending on caspase 1 activation by an unknown mechanism . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The aim of our study was to reduce neointimal proliferation after stenting of the porcine coronary artery , using the irreversible IL 1beta convertase and caspase 1 inhibitor acetyl tyrosinyl valyl alanyl aspartyl chloromethyl ketone ( Ac YVAD cmk ) . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We thus investigated the expression of IL 1 beta , IL 18 , and ICE mRNA and the secretion of the corresponding proteins by human normal gingival fibroblasts before and after stimulation with lipopolysaccharide ( LPS ) from Porphyromonas gingivalis and Escherichia coli . ^^^ IL 1 beta , IL 18 , and ICE mRNA expression was evaluated by RT PCR . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We measured the activity of IL 1beta converting enzyme ( ICE ) of monocytes from pulmonary tuberculosis ( PTB ) patients . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 inhibition significantly reduced IL 1beta production by SmT and SmD infected monocytes ( P < 0 . 05 , n = 4 ) . ^^^ CONCLUSIONS : Decreased mature IL 1beta release by SmT infected monocytes may reflect selective induction of caspase 1 activity but not caspase 3 . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| To exert biological activity , the precursors of both IL 1beta and IL 18 need to be cleaved by the interleukin 1beta converting enzyme ( ICE ) . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We show here that ASC binds by its CARD to procaspase 1 and to adapter proteins involved in caspase 1 activation , thereby regulating cytokine pro IL 1beta activation by this protease in THP 1 monocytes . ^^^ However , expression of ASC uniformly interferes with caspase 1 activation and IL 1beta secretion induced by proinflammatory stimuli such as LPS and TNF , suggesting pathway competition . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Its post translational processing by IL 1beta converting enzyme ( ICE ) and subsequent release from activated macrophages requires ATP acting on P2X7 receptors . ^^^ Little information is available on the production and release of fish IL 1beta , but the IL 1beta gene sequences reported to date lack a conserved ICE recognition site . ^^^ Notably , the post translational processing of IL 1beta by SAF 1 cells is abrogated by a specific ICE inhibitor . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| However , neither JNKI 1 nor JBD did influence IL 1beta induced NO synthesis or iNOS expression or the transcription of the genes encoding mitochondrial manganese superoxide dismutase ( MnSOD ) , catalase ( CAT ) , glutathione peroxidase ( GPx ) , glutathione S transferase rho ( GSTrho ) , heat shock protein ( HSP ) 70 , IL 1beta converting enzyme ( ICE ) , caspase 3 , apoptosis inducing factor ( AIF ) , Bcl 2 or Bcl xL . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1beta converting enzyme ( ICE ) and ICE related proteases ( IRPs ) have been suggested to play a central role in apoptosis . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 plays a key role in inflammatory pathways by processing pro IL 1beta into the active cytokine mature IL 1beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the development of osteoarthritis ( OA ) after transection of the medial collateral ligament and partial medial meniscectomy in mice in which genes encoding either interleukin 1beta ( IL 1beta ) , IL 1beta converting enzyme ( ICE ) , stromelysin 1 , or inducible nitric oxide synthase ( iNOS ) were deleted . ^^^ ICE , iNOS , and particularly IL 1beta knockout mice developed OA lesions in the lateral cartilage of unoperated limbs . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Casp 1 ( / ) bone marrow derived macrophages stimulated with lipopolysaccharide produced no detectable IL 18 , fourfold lower IL 1 beta , and 20 30 % less IL 1 alpha than macrophages from wild type Casp 1 ( + / + ) or Casp 1 ( + / ) controls . ^^^ These findings show that caspase 1 processing of IL 1 beta and IL 18 is not absolutely required for mediation of spontaneous or chemically induced diabetes pathogenesis in the NOD mouse . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 / interleukin 1beta ( IL 1beta ) converting enzyme ( ICE ) cleaves IL 1beta and IL 18 precursor proteins to the active forms of these proinflammatory cytokines . ^^^ Caspase 1 / interleukin 1beta ( IL 1beta ) converting enzyme ( ICE ) cleaves IL 1beta and IL 18 precursor proteins to the active forms of these proinflammatory cytokines . ^^^ The distribution pattern of caspase 1 immunoreactive structures is consistent with a role to produce mature IL 1beta in regions where IL 1beta mediates fever and sleep . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 [ IL 1beta converting enzyme ( ICE ) ] processes substrate precursor molecules to yield the biologically active form of IL 1beta and IL 18 , both of which are considered to play important roles in the host defense by activation of both innate and adaptive immunity . ^^^ Caspase 1 [ IL 1beta converting enzyme ( ICE ) ] processes substrate precursor molecules to yield the biologically active form of IL 1beta and IL 18 , both of which are considered to play important roles in the host defense by activation of both innate and adaptive immunity . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Differing caspase 1 activation states in monocyte versus macrophage models of IL 1beta processing and release . ^^^ The release of IL 1beta as an active , mature cytokine requires proteolytic processing by caspase 1 , which is recruited to signaling complexes that facilitate its autocatalytic proteolysis and activation . ^^^ These in vitro caspase 1 and IL 1beta processing reactions indicated a higher rate of constitutive caspase 1 activation in lysates from THP 1 vs . ^^^ The constitutive caspase 1 and IL 1beta processing reactions in THP 1 lysates were insensitive to pharmacological blockade by the tyrphostin , AG 126 , and the phospholipase A 2 inhibitor bromoenol lactone ( BEL ) ; contrarily , the same processing reactions were inhibited in lysates from Bac 1 cells pretreated with either AG 126 or BEL . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| After reperfusion , hearts were analyzed for expression of tissue TNF alpha , IL 1beta , and IL 6 ( ELISA ) and activation of p 38 MAPK , caspase 1 , caspase 3 , caspase 11 , and Bcl 2 ( Western blot ) . ^^^ After I / R , castrated male and flutamide treated male hearts had decreased TNF alpha , IL 1beta , and IL 6 ; decreased activated p 38 MAPK ; decreased caspase 1 , caspase 3 , and caspase 11 ; and increased Bcl 2 expression compared with untreated males . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Our observations have evidenced that suppression of ICE activation is required to counteract IL 1beta mediated islet beta cell toxicity , and that IL 1beta induced apoptosis is NO independent and involves the cytochrome c mitochondrial pathway . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In gene transfer experiments PAN 1 enhances caspase 1 activation and IL 1beta secretion in collaboration with ASC . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 is a cysteine protease composed by two 20 kDa and two 10 kDa subunits that processes pro IL 1beta and pro IL 18 to their mature forms . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In this study , the mRNA levels of interleukin 18 ( IL 18 ) , IL 1beta and their processing enzyme caspase 1 were quantified by a competitive RT PCR method in unstimulated peripheral blood mononuclear cells ( PBMCs ) in MS patients never treated with disease modifying drugs . ^^^ Analysis of clinical subgroups revealed that caspase 1 was increased in all subgroups , whereas IL 18 was upregulated in chronic progression ( P=0 . 001 ) and relapsing MS patients in remission ( P=0 . 002 ) but not significantly during relapses ( P=0 . 12 ) . mRNA levels of IL 1beta were not significantly altered in MS except for a possible decrease in chronic progression ( P=0 . 03 ) . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Production of macrophage IL 1beta was inhibited both at the levels of transcription and maturation by caspase 1 following inhalation exposure to isobutyl nitrite . ^^^ Caspase 1 , which cleaves the precursor IL 1beta into mature 17 kDa IL 1beta , was examined . ^^^ Nitrite inhalant exposure blocked activation induced increases in caspase 1 activity , consistent with a 50 % reduction in 17 kDa IL 1beta shown in Western blots . ^^^ Thus , exposure to nitrite inhalants reduced macrophage production of IL 1beta by reducing transcription , as well as post translational processing mediated by caspase 1 . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 , a mediator of the posttranslational processing of IL 1beta and IL 18 , requires an aspartic acid in the P 1 position of its substrates . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To test an inhibitor of IL 1beta converting enzyme ( ICE ) , with or without ciprofloxacin , in a C57BL / 6 mouse model of keratitis induced by Pseudomonas aeruginosa in which corneal perforation is expected . ^^^ Corneal protein levels for IL 1beta and MIP 2 also were reduced in mice treated with the ICE inhibitor versus placebo and in ICE inhibitor and ciprofloxacin versus ciprofloxacin and placebo treated mice . ^^^ CONCLUSIONS : Downregulation of IL 1beta by ICE together with ciprofloxacin to kill bacteria may provide alternate therapy to current treatment . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Regulation of Pseudomonas aeruginosa corneal infection in IL 1 beta converting enzyme ( ICE , caspase 1 ) deficient mice . ^^^ To elucidate these mechanisms , caspase 1 knockout ( ICE ( / ) ) mice , that do not release mature IL 1 beta after endotoxin challenge , were tested . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The presence of specific antibodies to IL 1beta or of a caspase 1 inhibitor blocked the secretion and production of the cytokine . ^^^ We concluded that A . actinomycetemcomitans leukotoxin can trigger abundant production and secretion of bioactive IL 1beta by human macrophages , which is mediated by activation of caspase 1 . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Neuronal cell death in the brain , as assessed by Fluoro Jade B and silver staining , peaked at 12 to 24 hours and was preceded by a marked increase in mRNA and protein levels of caspase 1 , IL 1beta , IL 18 , and IL 18 receptor alpha ( IL 18Ralpha ) . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| To determine the mechanism of this protection , the caspase 1 activated cytokines IL 1beta and IL 18 were investigated . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| A treatment with IL 1beta converting enzyme ( ICE ) specific inhibitor prevented IL 1beta secretion by epithelial cells stimulated by P . gingivalis LPS and decreased the levels of shed syndecan 1 ectodomain . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Herein , we provide evidence that inflammation in the CINCA syndrome is characterized by enhanced interleukin 1beta ( IL 1beta ) and IL 18 release upon stimulation of blood cells and show that this release is caspase 1 dependent . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| After stimulation of TLR 4 with lipopolysaccharide ( LPS ) , both IL 1beta and IL 18 are processed , depending on the activation of caspase 1 , although its mechanism remains unclear . ^^^ These results demonstrate critical roles for ASC in the release of IL 1beta / IL 18 via activation of caspase 1 and provide new insights into the inflammatory responses for host defence and diseases . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| By using gene transfer and RNA interference approaches , we demonstrate in this study that CLAN modulates endogenous caspase 1 activation and subsequent IL 1beta secretion from human macrophages after exposure to LPS , peptidoglycan , and pathogenic bacteria . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Activation of caspase 1 and subsequent processing and secretion of the pro inflammatory cytokine IL 1beta is triggered upon assembly of the inflammasome complex . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Chlamydia induced IL 1beta and IL 18 secretion required infection with viable bacteria and was associated with the Chlamydia induced activation of caspase 1 in infected host cells . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Most important , we observed a role of Rac1 / PAK1 signaling in activation of caspase 1 , which is necessary for maturation of pro IL 1beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Nonetheless , the IL 1beta processing mechanism in non mammalian vertebrates remains unclear because , with the exception of three bony fish , all non mammalian IL 1beta sequences discovered so far lack an ICE ( Interleukin Converting Enzyme ) cut site . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The first is immune mediated death which may operate through the receptor ligand pathway activated by caspase 1 and the pro inflammatory cytokine , IL 1beta . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry was used to localize five members of the IL 1 family ( IL 1alpha , IL 1beta , IL 1Ra ( IL 1 receptor antagonist ) , IL 1RI ( IL 1 receptor , type 1 ) , and ICE ( IL 1beta converting enzyme ) ) in non degenerate and degenerate human IVDs . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Poly ( ADP ribose ) polymerase fragmentation , caspase 1 activation , and IL 1beta and ICAM 1 mRNA expression were increased by hypoxia ischemia and significantly reduced in simvastatin treated animals . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Mutations in cryopyrin are hypothesized to result in abnormal secretion of caspase 1 dependent proinflammatory cytokines , IL 1beta and IL 18 . ^^^ VX 765 , an orally active IL converting enzyme / caspase 1 inhibitor , blocked IL 1beta secretion with equal potency in LPS stimulated cells from FCAS and control subjects . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| This effect was suppressed by an inhibitor of caspase 1 , the protease which cleaves pro IL 1beta . ^^^ Inhibition of caspase 1 did not influence IL 1beta mRNA expression . ^^^ In conclusion , VLDL induces IL 1beta mRNA expression , caspase 1 activation , and IL 1beta release from macrophages , suggesting that VLDL can promote inflammation in atherosclerotic lesions . . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 ( ICE interleukin 1 converting enzyme ) , directly connected with apoptosis and responsible for the cleavage of IL 1b and IL 18 , is also a member of the IL 1 family . ^^^ Caspase 1 ( ICE interleukin 1 converting enzyme ) , directly connected with apoptosis and responsible for the cleavage of IL 1b and IL 18 , is also a member of the IL 1 family . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The SPI 1 effector SipB activates caspase 1 in macrophages , releasing IL 1beta and IL 18 and inducing rapid cell death by a mechanism that has features of both apoptosis and necrosis . ^^^ In the intestine , the Salmonella SPI 1 TTSS and SipB mediate macrophage death by caspase 1 activation , which also releases IL 1beta and IL 18 , promoting inflammation and subsequent phagocytosis by incoming macrophages and leading to dissemination to systemic tissues . ^^^ |
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| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Neuroprotection by the caspase 1 inhibitor Ac YVAD ( acyloxy ) mk in experimental neuroAIDS is independent from IL 1beta generation . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1RI , IL 1RII , and IL 1Ra were all up regulated , whereas the IL 1beta converting enzyme , caspase 1 , and IRAK M were down regulated . ^^^ LPS inducible caspase 1 enzyme activity was also reduced in IL 13 stimulated monocytes , with a consequent decrease in pro IL 1beta processing . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The ICE inhibitor Z YVAD FMK prevented the release of IL 1beta evoked by DNFB . ^^^ The rapid effect of DNFB on the release of mature IL 1beta , without inducing an increase of IL 1beta mRNA in FSDC , suggests a posttranslational modification of pro IL 1beta by ICE activity . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In this study , we provide evidence that H . somnus LOS increases IL 1alpha and IL 1beta mRNA expression , and caspase 1 activation in endothelial cells . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In experiment 2 , rats treated neonatally with E . coli or PBS received as adults either saline or a centrally administered caspase 1 inhibitor , which specifically prevents the synthesis of IL 1beta , 1 h before a learning event and subsequent LPS challenge . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 mediates inflammation though the activation of the cytokines interleukin 1beta ( IL 1beta ) and interleukin 18 ( IL 18 ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1beta is a proinflammatory cytokine initially synthesized in an inactive precursor form that is cleaved by caspase 1 to generate the biologically mature form . ^^^ In the present study , cleavage of IL 1beta was chronically inhibited using a specific caspase 1 inhibitor ( Ac YVAD CMK ; 10 pmol ) in both aged ( 22 month ) and young ( 4 month ) rats . ^^^ Chronic infusion of a specific caspase 1 inhibitor in aged rats ameliorated age related increases in hippocampal IL 1beta and improved memory for context . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In the present study , we have evaluated the effect of high cholesterol ( HC ) diet on the expression of interleukin 6 ( IL 6 ) , a cytokine involved in neurodegeneration , and caspase 1 , that is responsible for the cleavage of the precursors of interleukin 1 beta ( IL 1 beta ) and interleukin 18 ( IL 18 ) in the brain of apolipoprotein E ( Apo E ) knock out ( KO ) and wild type ( WT ) mice . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The concentration of sFasL , ICE and IL 1beta in the serum and the liver tissue of chronic HCV infected patients . ^^^ The concentration of IL 1beta , ICE and sFasL in the serum and liver tissue was analyzed before treatment was begun . ^^^ The concentrations of IL 1beta , ICE and sFasL after 2 and 12 weeks of treatment were also analyzed . ^^^ The concentrations of IL 1beta , ICE and sFasL in the liver tissue of patients with hepatitis C were compared with the concentrations in liver tissue of patients with alcohol related liver damage , but not HBV or HCV infected . ^^^ The concentration of ICE and IL 1beta in the liver tissue of patients with hepatitis C was compared to concentrations in the liver tissue of patients with alcohol related liver damage . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 32 synergizes with nucleotide oligomerization domain ( NOD ) 1 and NOD 2 ligands for IL 1beta and IL 6 production through a caspase 1 dependent mechanism . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The focus of this review will be on those inhibitors of cytokine production , which target either p 38 mitogen activated protein ( MAP ) kinase , TNF alpha converting enzyme ( TACE ) , or IL 1beta converting enzyme ( ICE ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The proinflammatory cytokines IL 1beta and IL 18 are inactive until cleaved by the enzyme caspase 1 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Inhibitory effects of chloride on the activation of caspase 1 , IL 1beta secretion , and cytolysis by the P2X7 receptor . ^^^ The P2X7 receptor ( P2X7R ) is an ATP gated cation channel that activates caspase 1 leading to the maturation and secretion of IL 1beta . ^^^ Because previous studies indicated that extracellular Cl exerts a negative allosteric effect on ATP gating of P2X7R channels , we tested whether Cl attenuates the P2X7R > caspase 1 > IL 1beta signaling cascade in murine and human macrophages . ^^^ Our observations were consistent with actions of Cl at three levels : 1 ) a negative allosteric effect of Cl , which limits the ability of ATP to gate the P2X7R mediated cation fluxes that trigger caspase 1 activation ; 2 ) an intracellular accumulation of Cl via nonselective pores induced by P2X7R with consequential repression of caspase 1 mediated processing of IL 1beta ; and 3 ) a facilitative effect of Cl substitution on the cytolytic release of unprocessed pro IL 1beta that occurs with sustained activation of P2X7R . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We report here the identification and characterization of a poxvirus encoded PYD containing protein that interacts with the ASC 1 component of the inflammasome and inhibits caspase 1 activation and the processing of IL 1beta and IL 18 induced by diverse stimuli . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| A potent adjuvant monophosphoryl lipid A triggers various immune responses , but not secretion of IL 1beta or activation of caspase 1 . ^^^ Moreover , MPL , unlike E . coli type lipid A , failed to induce activation of caspase 1 , which catalyzes IL 1beta precursor processing . ^^^ These results suggest that an immune response without activation of caspase 1 or secretion of IL 1beta results in the low toxicity of this adjuvant . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Cryopyrin and ASC are essential for caspase 1 activation and IL 1beta and IL 18 production in response to bacterial RNA and the imidazoquinoline compounds R 837 and R 848 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Macrophages from mice deficient in various components of the inflammasome such as caspase 1 , ASC and NALP 3 are defective in crystal induced IL 1beta activation . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In contrast to Asc / macrophages , cells deficient in the gene encoding cryopyrin ( Cias 1 / ) activated caspase 1 and secreted normal levels of IL 1beta and IL 18 when infected with Gram negative Salmonella typhimurium or Francisella tularensis . ^^^ Macrophages exposed to Gram positive Staphylococcus aureus or Listeria monocytogenes , however , required both ASC and cryopyrin to activate caspase 1 and secrete IL 1beta . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Furthermore , in IL 1beta / mice , increased caspase 1 expression was seen compared with wild type animals . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1beta and IL 18 are closely related ; both possess a similar three dimensional structure , and their respective precursor forms are inactive until cleaved by the intracellular cysteine protease caspase 1 . ^^^ Patients with mutations in the NALP 3 gene , which controls the activity of caspase 1 , readily secrete more IL 1beta and IL 18 and suffer from systemic inflammatory diseases . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 is a key endopeptidase responsible for the post translational processing of the IL 1beta and IL 18 cytokines and small molecule inhibitors that modulate the activity of this enzyme are predicted to be important therapeutic treatments for many inflammatory diseases . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NALP 3 was essential for the ATP driven activation of caspase 1 in lipopolysaccharide stimulated macrophages and for the efficient secretion of the caspase 1 dependent cytokines IL 1alpha , IL 1beta , and IL 18 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In contrast , secretion of IL 1beta , IL 6 , and TNF alpha was reduced in TLR 2 deficient macrophages infected with Listeria ; this was associated with impaired activation of NF kappaB and p 38 , but normal caspase 1 processing . ^^^ Analysis of Listeria mutants revealed that cytosolic invasion was required for ASC dependent IL 1beta secretion , consistent with a critical role for cytosolic signaling in the activation of caspase 1 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The expressions of caspase 1 , interleukin ( IL ) 18 and IL 1beta mRNA in the cerebral cortex were detected by RT PCR . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Active caspase 1 , which is required for the processing and secretion of IL 18 and IL 1beta , was activated in simvastatin treated monocytes . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Notably , the protease function of caspase 12 was not necessary for this effect , as the catalytically inactive caspase 12 mutant Cys299Ala also inhibited caspase 1 and IL 1beta production to the same extent as wild type caspase 12 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IL 1beta converting enzyme ( ICE ) activity was measured by an ICE colorimetric assay . ^^^ RESULTS : Addition of H . pylori at 300 mosM caused significant increases in IL 1beta mRNA , IL 1beta protein , ICE activity and apoptosis . ^^^ Hyperosmotic stress alone also caused upregulation of IL 1beta mRNA and IL 1beta protein , enhanced ICE activity and accelerated apoptosis . ^^^ Hyperosmotic stress accentuated the increases in IL 1beta mRNA , IL 1beta protein , ICE activity and apoptosis induced by H . pylori alone . ^^^ Enhancement of IL 1beta protein release induced by hyperosmotic stress was significantly attenuated by an ICE inhibitor , Z YVAD FMK . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Several of the more potent ICE inhibitors were also shown to inhibit IL 1beta production in a whole cell assay ( IC ( 50 ) < 500 nM ) . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In conclusion , chylomicron remnants stimulated IL 1beta mRNA expression and IL 1beta protein production probably via caspase 1 and NF kappaB activation in THP 1 cells . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 ( Casp 1 ) mediates the processing of the proinflammatory cytokines interleukin 1beta ( IL 1beta ) and IL 18 to their mature forms . ^^^ Both Casp 1 substrates , IL 18 and IL 1beta , are relevant for control of Salmonella enterica serovar Typhimurium . ^^^ We used IL 18 / and IL 1beta / mice in addition to administration of recombinant IL 18 to Casp 1 / mice to demonstrate that IL 18 is important for resistance to the systemic infection but not for resistance to the intestinal phase of the infection . ^^^ Caspase 1 mediated activation of interleukin 1beta ( IL 1beta ) and IL 18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection . ^^^ Caspase 1 ( Casp 1 ) mediates the processing of the proinflammatory cytokines interleukin 1beta ( IL 1beta ) and IL 18 to their mature forms . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated whether seizures can be effectively inhibited by blocking the brain production of IL 1beta , by using selective inhibitors of interleukin converting enzyme ( ICE / caspase 1 ) or through caspase 1 gene deletion . ^^^ RESULTS : Caspase 1 inhibition reduced the release of IL 1beta in organotypic slices exposed to LPS+ATP . ^^^ CONCLUSIONS : Inhibition of caspase 1 represents an effective and novel anticonvulsive strategy , which acts by selectively reducing the brain availability of IL 1beta . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Further in vitro analysis of peritoneal macrophages from IFN beta ( / ) , Stat 1 ( / ) , and caspase 1 ( / ) mice and their wild type controls following LPS stimulation demonstrated that IL 1beta mRNA was expressed in these mice but not in macrophages from MyD 88 ( / ) mice . ^^^ Despite the presence of IL 1beta mRNA , IL 1beta protein was markedly reduced in the absence of Stat 1 activation in macrophages derived from IFN beta ( / ) and Stat 1 ( / ) mice or in the absence of caspase 1 activity , which itself was dependent on Stat 1 activation . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| These mammalian proteins encode novel cysteine proteases with homology to the interleukin 1 beta converting enzyme ( ICE ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Expression of interleukin 1 beta converting enzyme ( ICE ) correlated with the loss of ECM , and inhibitors of ICE activity prevented apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The only reported target for the CrmA protein is the cysteine protease interleukin 1 beta converting enzyme ( ICE ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The B30 . 2 domain of pyrin , the familial Mediterranean fever protein , interacts directly with caspase 1 to modulate IL 1beta production . ^^^ Pyrin , the protein mutated in FMF , regulates caspase 1 activation and consequently IL 1beta production through cognate interaction of its N terminal PYRIN motif with the ASC adaptor protein . ^^^ Full length pyrin attenuated IL 1beta production in cells transfected with a caspase 1 / IL 1beta construct , an effect diminished by FMF associated B30 . 2 mutations and in B30 . 2 deletion mutants . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) is composed of 10 ' ( p 10 ) and 20 kDa ( p 20 ) subunits , which are derived from a common 45 kDa precursor . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Using oligomer primers based on the cDNA sequence of human interleukin 1 beta converting enzyme ( ICE ) , we have employed the RT PCR method and rat spleen RNA to clone and sequence rat ICE . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) is a cytoplasmic cysteine protease required for generating the bioactive form of the interleukin 1 beta cytokine from its inactive precursor . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The substrate specificity of granzyme B , requiring an aspartic acid residue at site P 1 , is unique among eukaryotic serine proteases and is shared with only one other known eukaryotic protease , interleukin 1 beta converting enzyme ( ICE ) . ^^^ ICE is responsible for processing pro interleukin 1 beta to produce biologically active interleukin 1 beta and is itself synthesized as an inactive precursor . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Vaccination with streptococcal extracellular cysteine protease ( interleukin 1 beta convertase ) protects mice against challenge with heterologous group A streptococci . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The CrmA protein is a serpin family protease inhibitor than can inhibit interleukin 1 beta converting enzyme ( ICE ) and ICE like proteases . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to determine whether a synthetic inhibitor of the interleukin 1 beta converting enzyme ( ICE ) displays oral activity in models of inflammation . 2 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The cleavage enzyme , designated SREBP cleavage activity ( SCA ) , belongs to a new class of cysteine proteases of the interleukin 1 beta converting enzyme ( ICE ) family , all of which cleave at aspartic acid residues . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We also show that mitogen induction of the interleukin 1 beta converting enzyme ( ICE ) gene , a mammalian homologue of the Caenorhabditis elegans cell death gene ced 3 , is IRF 1 dependent . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| A recent study suggested that PARP cleavage can be mediated by a novel cytosolic protease ( prICE ) that resembles interleukin 1 beta converting enzyme ( ICE ) , but can not be mediated by ICE itself ( Lazebnik , Y . ^^^ PARP cleavage , however , requires a 50 100 fold higher ICE concentration than does processing of the interleukin 1 beta precursor at an equivalent substrate concentration . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The activity of bvICE was determined by conversion of precursor interleukin 1 beta ( preIL 1 beta ) to the mature form ( mIL 1 beta ) and via site specific cleavage of a decapeptide which spans the ICE cleavage site in preIL 1 beta . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) is a cysteine protease in monocytes that is essential for the proteolytic activation of interleukin 1 beta , an important mediator of inflammation . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) is a mammalian homolog of CED 3 , a protein required for programmed cell death in the nematode Caenorhabditis elegans . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Hydroquinone also inhibits the processing of pre interleukin 1 beta by interleukin 1 beta convertase . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Strain subsets were also examined by automated DNA sequencing for allelic polymorphism in genes encoding M protein ( emm ) , streptococcal pyrogenic exotoxin A ( speA ) , streptokinase ( ska ) , pyrogenic exotoxin B ( interleukin 1 beta convertase ) ( speB ) , and C5a peptidase ( scp ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| To understand the mechanism of interleukin 1 beta converting enzyme ( ICE ) activation in apoptosis , we analyzed the expression of ICE mRNA in two human cell lines by reverse transcription polymerase chain reaction technique . ^^^ Although all the alternative splicing events were within the coding sequence of ICE , the four ICE isoforms maintained open reading frames and were designated as ICE beta , gamma , delta , and epsilon . ^^^ Examination of the ability of these four ICE isoforms to cause apoptosis revealed that only the parental ICE alpha and isoforms beta and gamma , but not isoforms delta and epsilon , can induce apoptosis when overexpressed in Sf 9 insect cells . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Preparation and evaluation of peptidic aspartyl hemiacetals as reversible inhibitors of interleukin 1 beta converting enzyme ( ICE ) . ^^^ Aspartyl aldehyde , Ac Tyr Val Ala Asp H 1 ( L 709 , 049 ) , has been reported to be a potent , reversible inhibitor of interleukin 1 beta converting enzyme ( ICE ) [ Thornberry , N . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We reported previously that human interleukin 1 beta converting enzyme ( ICE ) is regulated by the CrmA serpin encoded by cowpox virus . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) processes an inactive precursor to the proinflammatory cytokine , interleukin 1 beta , and may regulate programmed cell death in neuronal cells . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| EI 1507 1 and 2 , novel interleukin 1 beta converting enzyme ( ICE ) inhibitors , were isolated from the culture broths of Streptomyces sp . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Apoptosis mediated by interleukin 1beta converting enzyme ( ICE ) , which can be inhibited by Orgyia pseudotsugata nuclear polyhedrosis virus IAP ( OpIAP ) and cowpox virus crmA , was also inhibited by MIHA and MIHB . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The contrasting roles of ICE family proteases and interleukin 1beta in apoptosis induced by trophic factor withdrawal and by copper / zinc superoxide dismutase down regulation . ^^^ To determine whether the ICE [ interleukin 1beta converting enzyme ] family of proteases , which is required for apoptosis on trophic factor withdrawal , is also required for apoptosis induced by oxidative stress , we have developed a novel peptide inhibitor that mimics the common catalytic site of these enzymes and thereby blocks their access to substrates . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Moreover , cleavage of PKC delta occurs adjacent to aspartic acid at a site ( QDN ) similar to that involved in proteolytic activation of interleukin 1 beta converting enzyme ( ICE ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Expression of sulfated glycoprotein 2 ( SGP 2 ) , interleukin 1 beta converting enzyme ( ICE ) and tissue inhibitor of metalloproteinases 1 was upregulated at day 2 , when apoptotic cells were seen initially . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We have identified and characterized a novel cysteine protease named CMH 1 that is a new member of the interleukin 1 beta converting enzyme ( ICE ) family of proteases with substrate specificity for Asp 10 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Moreover , the interleukin 1 beta converting enzyme ( ICE ) family of cysteine proteases is now known to play a key role in apoptosis but has no discernible role in the cell cycle , arguing that the two processes are discrete . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The present study describes the identification and molecular cloning of a new member of the interleukin 1 beta converting enzyme ( ICE ) family denoted transcript Y ( TY ) . ^^^ However , despite the close similarity between TY and ICE active sites , TY fails to process the interleukin 1 beta precursor . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| RPR mediated apoptosis was blocked by N benzyloxycarbonyl Val Ala Asp fluoromethylketone ( Z VAD fmk ) , which suggests that an interleukin 1 beta converting enzyme ( ICE ) like protease is required for RPR function . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The primary sequence similarities between Ced 3 and the mammalian interleukin 1beta converting enzyme ( ICE ) suggest that these two proteins may have functionally similar active sites and that Ced 3 may function as a cysteine protease . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Moreover , introduction of chromosome 22 into UK 110 can complement the processing of interleukin 1 beta converting enzyme ( ICE ) like proteases , such as CPP32 / Yama / Apopain and ICH 1L , after treatment with anti Fas and anti p 55 TNFR antibodies . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Identification and characterization of Ich 3 , a member of the interleukin 1beta converting enzyme ( ICE ) / Ced 3 family and an upstream regulator of ICE . ^^^ The predicted amino acid sequence of Ich 3 protein shares 54 % identity with murine interleukin 1beta converting enzyme ( ICE ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The role of poly ( ADP ribose ) in apoptosis , carcinogenesis , and aging could be studied by the use of modulators of PARP activity ( 3 aminobenzamide , 3 nitrosobenzamide , 1 % ethanol , etc . ) , inhibitors of poly ADP ribose ) glycohydrolase activity ( ethacridine , 43 degrees C , etc . ) , and inhibitors of the PARP specific protease ( interleukin 1 beta converting enzyme ( ICE ) like protease ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In contrast , members of the human interleukin 1beta converting enzyme ( ICE ) family of cysteine proteases and their C . elegans homologue CED 3 promote the death program . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The necrotic cell death is also retarded by inhibitors of ICE ( like ) proteases , including interleukin 1beta converting enzyme ( ICE ) , which are common mediators of apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) like proteases , which are synthesized as inactive precursors , play a key role in the induction of apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| PCD of neurons is blocked by inhibitors of the interleukin 1beta converting enzyme ( ICE ) / Ced 3 like cysteine protease , indicating involvement of this class of proteases in the cell death programme . ^^^ This order of events was confirmed in macrophages where lactacystin inhibited the proteolytic activation of precursor ICE and the subsequent generation of active interleukin 1beta . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Using a GST IpaB fusion protein as a ligand in affinity purification , we isolated four IpaB binding proteins from macrophages which were identified as the precursor and the mature polypeptides of interleukin 1beta converting enzyme ( ICE ) or a highly homologous protease . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Cysteine proteases related to mammalian interleukin 1 beta converting enzyme ( ICE ) and to its Caenorhabditis elegans homologue , CED 3 , play a critical role in the biochemical events that culminate in apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The authors examined the expression of the apoptosis related modulators , Fas ( receptor ) , Fas ligand , Bax , Bcl 2 , Bcl XL , and interleukin 1 beta converting enzyme ( ICE ) in corneal cells as candidate mediators of this response and tested the effect of Fas receptor stimulating antibody on corneal stromal fibroblast cells in vitro . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In various cell types , Fas or TNF alpha induced apoptosis is blocked by viral proteins ( such as p 35 and CrmA ) as well as by a decoy peptide ( YVADcmk ) [ 7 11 ] , suggesting that these mechanisms of apoptosis involve ICE ( interleukin 1 beta converting enzyme ) like proteases . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) or human immunodeficiency virus protease failed to induce DNA fragmentation in naive nuclei . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The exact events involved in the induction of target cell apoptosis remain elusive , but research indicates a role for members of the interleukin 1beta converting enzyme ( ICE ) / Ced 3 family of cysteine proteases . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We report the preparation and characterization of interleukin 1beta converting enzyme ( ICE ) refolded from its p 20 and p 10 protein fragments . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Pro interleukin 1 beta converting enzyme ( ICE ) activity in the pituitary was found to be significantly increased 4 h after intraperitoneal injection of E . coli lipopolysaccharides , when distribution and inducibility of the enzyme was studied in the adult rat brain and the adrenal gland , using an artificial fluorescence peptide substrate . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that deprivation of basic fibroblast growth factor ( bFGF ) increased the expression of interleukin 1 beta converting enzyme ( ICE ) protein , and subsequently induced apoptosis in murine aortic endothelial ( MAE ) cells . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Although the interleukin 1beta converting enzyme ( ICE ) / CED 3 family of proteases has been implicated recently in neuronal cell death in vitro and in ovo , the role of specific genes belonging to this family in cell death in the nervous system remains unknown . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) defines a new class of mammalian cysteine protease that shares strong homology with the Caenorhabditis elegans death gene ced 3 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Using a fluorogenic substrate for interleukin 1beta converting enzyme ( ICE ) , we show that K+ deprivation of cerebellar granule neurons induces cycloheximide sensitive ICE like protease activity . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Apoptosis signals are further modulated by inhibitors or inducers of apoptosis including Bcl 2 , p 53 , and interleukin 1 beta converting enzyme ( ICE ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| On the other hand , tumor sensitization may result from activation of `` killing ' ' proteins such as interleukin 1 beta converting enzyme ( ICE ) or other ICE like proteases , possibly through TNF / LT induced oxygen free radicals . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| To characterize the nature of programmed cell death ( PCD ) induced in neuronal cells during development , three regulators of apoptosis were investigated : one , the bcl 2 related genes , modulate cell survival , and the other two , the interleukin 1 beta converting enzyme ( ICE ) related enzymes and the tumor suppressor protein p 53 , have been implicated as mediators of apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The cysteine protease interleukin 1beta converting enzyme ( ICE ) is implicated as an effector of apoptosis in mammalian cells . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Although both ceramide and interleukin 1beta converting enzyme ( ICE ) family proteases are key molecules during apoptosis , their relationship remains to be elucidated . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1beta converting enzyme ( ICE ) has been identified as the main protease responsible for maturation of the prodomain of interleukin 1beta . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Apoptosis of both cells and cytoplasts was associated with proteolytic processing of CPP 32 , a member of the interleukin 1beta converting enzyme ( ICE ) / CED 3 protease family , to its active form . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Oligonucleotides to interleukin 1 beta convertase ( ICE ) , which detected the expected 2 kb transcript and two lesser 1 . 5 and 3 kb hybridizing species , demonstrated slight mRNA induction in the CA 1 region at 72 h following ischemia . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Other enzymes characterized by a strong preference for negatively charged residues in the P 1 position , e . g . , interleukin 1 beta converting enzyme ( ICE ) , use Arg or Lys residues as counterions within the S 1 binding site . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The identification of the Caenorhabditis elegans cell death gene , ced 3 , as a prototype of the interleukin 1beta converting enzyme ( ICE ) protease family has led to extensive evidence implicating these enzymes in apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Inhibitors of interleukin 1beta converting enzyme ( ICE ) and a related group of cysteine aspartases of the ICE / ced 3 family inhibit cell death in a variety of settings , including in PC 12 cells and sympathetic neurons following withdrawal of trophic support . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We describe the expression , purification , and characterization of human interleukin 1 beta converting enzyme ( ICE ) containing an affinity tag and modified to resist autoproteolysis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| IAP was transiently expressed in mammalian cells and its ability to block cell death caused by expression of interleukin 1 beta converting enzyme ( ICE ) , FADD , or the ICE homologues ICH 1 and ICE Lap 3 , was investigated . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The interleukin 1 beta converting enzyme ( ICE ) like Ac YVAD MCA hydrolytic activity was increased about 6 fold by treatment with retinoic acid . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We have studied the effects of the baculovirus genes p 35 from Autographa californica nuclear polyhedrosis virus and IAP from Orgyia pseudotsugata nuclear polyhedrosis virus on cell death induced in HeLa cells by over expression of interleukin 1 beta converting enzyme ( ICE ) , overexpression of the CD 95 associated protein FADD , or cell death induced by treatment with TNF plus cycloheximide . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In addition , IFN gamma caused an increased expression of the interleukin 1 beta converting enzyme ( Ice ) gene , following strong induction of the interferon regulatory factor 1 ( IRF 1 ) gene , the product of which is a transcriptional activator of the Ice gene . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Different interleukin 1 beta converting enzyme ( ICE ) family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli . ^^^ Two cell permeable peptide fluoromethyl ketone inhibitors of Interleukin 1 beta converting enzyme ( ICE ) family proteases were tested as inhibitors of apoptotic cell death of T lymphocytes at various stages of differentiation . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| To clarify the possible roles of the genes involved in the cell death program , this study examined the expression of three members of the interleukin 1 beta converting enzyme ( Ice ) gene family ( Ice , Nedd 2 , and Yama / CPP32 ) and two members of the bcl 2 gene family ( bcl 2 and bcl 10 ) in the rat brain after permanent occlusion of the middle cerebral artery . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| EI 1511 3 , 5 and EI 1625 2 , novel interleukin 1 beta converting enzyme ( ICE ) inhibitors , were isolated from the culture broths of Streptomyces sp . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| EI 1511 3 , 5 and EI 1625 2 , novel interleukin 1 beta converting enzyme ( ICE ) inhibitors from the culture broths of Streptomyces sp . selectively inhibited the recombinant human ICE activity with IC 50 values of 0 . 09 , 0 . 38 and 0 . 2 microM , respectively , without inhibiting elastase and cathepsin B . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Apoptosis induced by gp 120 in the Th 1 clones is inhibited by either an anti CD 95 neutralizing MoAb or an anti CD95L neutralizing MoAb as well as by a specific interleukin 1 beta converting enzyme ( ICE ) inhibitor . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Engagement of CD 95 or tumor necrosis factor 1 receptor ( TNFR 1 ) by ligand or agonist antibodies is capable of activating the cell death program , the effector arm of which is composed of mammalian interleukin 1beta converting enzyme ( ICE ) like cysteine proteases ( designated caspases ) that are related to the Caenorhabditis elegans death gene , CED 3 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the peptide inhibitor of interleukin 1beta converting enzyme ( ICE ) like proteases , Z VAD . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) is the first enzyme of a new family of cysteine endoproteinases to be isolated and characterized . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Furthermore , triggering of lymphocytes from HIV infected persons by CH 11 increased levels of interleukin 1beta converting enzyme ( ICE ) , a protein associated with apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) is a mammalian homolog of CED 3 , a protein required for programmed cell death in nematode Caenorhabditis elegans . ^^^ We found that a selective inhibitor of ICE / ced 3 family proteases , benzyloxycarbonyl Asp CH2OC ( O ) 2 6 , dichlorobenzene ( Z Asp CH 2 DCB ) . completely blocked the apoptotic cell death of human leukemia cells caused by etoposide , camptothecin , 1 beta D arabinofuranosyl cytosine ( Ara C ) and adriamycin . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Other investigated apoptosis associated factors comprised interleukin 1 beta converting enzyme ( ICE ) , mediating cell death by cleavage of actin filaments , as well as bcl 2 and bcl 10 , both inhibiting apoptosis by acting as antioxidants . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| To explore further the protective mechanism ( s ) elicited by bcl 2 expression , we investigated whether BCL 2 could prevent NO induced cleavage of poly ADP ribose polymerase ( PARP ) , which is a substrate for interleukin 1 beta converting enzyme ( ICE ) like proteases in apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In contrast , no activation of caspase 1 ( interleukin 1beta converting enzyme ( ICE ) ) was observed . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We also showed that , although the steady state level of the corresponding proteins is not profoundly affected , they are substrates for an interleukin 1 beta converting enzyme ( ICE ) like protease activated during the process . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Apoptosis has recently been shown to depend on the activation of a class of proteases with homology to Interleukin 1 beta converting enzyme ( ICE ) protease . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) has been the focus of major scientific efforts to discover pharmaceutically effective inhibitors . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) is a cysteine protease responsible for proteolytic activation of the biologically inactive interleukin 1 beta precursor to the proinflammatory cytokine . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In this study , we found that either etoposide ( VP 16 ) or camptothecin ( CPT ) activated c Jun N terminal kinase 1 / stress activated protein kinase ( JNK1 / SAPK ) , transient c jun expression , and ICE ( interleukin 1beta converting enzyme ) / CED 3 like proteases in U 937 cells . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Proteases of the interleukin 1 beta converting enzyme ( ICE ) family have been implicated as mediators of apoptosis in several cell types . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Two irreversible inhibitors of the interleukin 1 beta converting enzyme ( ICE ) and related proteases , Z Val Ala Asp CH2F and acetyl Tyr Val Ala Asp chloromethyl ketone , blocked neuronal death produced by A beta ( 25 35 ) , staurosporine , and NMDA to differing extents . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| To clarify differences in the biological roles of the interleukin 1beta converting enzyme ( ICE ) family proteases , we have examined in detail the specificities beyond the P 1 position of caspase 1 , 2 , 3 , 4 , 6 , and 7 toward minimal length peptide substrates in vitro . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Stimulation of Fas by Fas ligand or agonistic antibodies results in the activation of interleukin 1 beta converting enzyme like ( ICE like ) proteases , and proteolytic cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The ced 9 and ced 3 genes were found to encode proteins that share structural and functional similarities with the mammalian proto oncogene product Bcl 2 and interleukin 1 beta converting enzyme ( ICE ) , respectively . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The two genes CED 4 and CED 3 ( the nematode homologue of interleukin 1beta converting enzyme , ICE ) of Caenorhabditis elegans are implicated in the control of cell death , but the mechanism by which this occurs is unknown . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Employing a baculovirus expression system , human interleukin 1beta converting enzyme ( ICE ) has been expressed in Trichoplusia ni High Five insect cells and purified . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Northern and Western blot analyses revealed induction of message and protein for the interleukin 1 beta converting enzyme ( ICE ) , which has been shown to mediate apoptosis induced by TNF alpha . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Cloning of interleukin 1 beta converting enzyme ( ICE ) and Caenorhabditis elegans death protein CED 3 revealed the structural and functional homology between these two proteases . ^^^ Several CED 3 and ICE like cysteine proteases have been described , including Nedd2 / Ich 1 , CPP 32 beta , Tx , ICErel 3 , and Mch 2 . ^^^ We have previously described a mouse ortholog of cysteine protease CPP 32 beta that shares strong homology with ICE and CED 3 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The Nedd2 / Ich 1 protein belongs to a growing family of mammalian cysteine proteases similar to interleukin 1 beta converting enzyme ( ICE ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Suppression of interleukin 1beta converting enzyme ( ICE ) induced apoptosis by SV 40 large T antigen . ^^^ The Interleukin 1beta converting enzyme ( ICE ) family of proteins , homologs of the C elegans cell death gene product CED 3 , play important roles in controlling vertebrate programmed cell death . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Identification of the processing / activation of multiple interleukin 1beta converting enzyme ( ICE ) like proteases and their target substrates in the intact cell is critical to our understanding of the apoptotic process . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We used transgenic mice expressing a dominant negative mutation of interleukin 1 beta converting enzyme ( ICE ) ( C285G ) in a model of transient focal ischemia in order to investigate the role of ICE in ischemic brain damage . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The interleukin 1 beta converting enzyme ( ICE ) family of cysteine proteases has been implicated in apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The caspase 3 ( CPP 32 ) activity was increased in a time dependent manner by treatment with 50 microM GGO , whereas no activation of caspase 1 ( interleukin 1beta converting enzyme ( ICE ) ) was observed in any time period under the same experimental conditions . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Programmed cell death is mediated by members of the interleukin 1 beta convertase family of proteases , which are activated in response to diverse cell death stimuli . ^^^ Here we report that the MDM 2 oncoprotein is cleaved by members of the CPP 32 subfamily of interleukin 1 beta convertase proteases both in vitro and in vivo , resulting in the disappearance of MDM 2 from apoptotic cells . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We assessed the expression of several genes encoding pro apoptotic cysteine proteases similar to interleukin 1 beta converting enzyme ( ICE ) and nematode Ced 3 in association with delayed neuronal death ( DND ) after transient forebrain ischemia in Mongolian gerbil . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| CPT 11 initiated cytolytic activity was prevented by both caspase inhibitors YVAD CHO and DEVD CHO , or ceramide synthesis inhibitor fumonisin B 1 , and accelerated by sphingomyelin , suggesting the direct involvement of ceramide synthesis and the interleukin 1 beta converting enzyme ( ICE ) cascade . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Apoptosis induced in rat hepatocytes by transforming growth factor beta 1 ( TGF beta 1 ) was accompanied by the activation of interleukin 1beta converting enzyme ( ICE ) like proteases . ^^^ Cell lysates were isolated at various times after TGF beta 1 treatment and analyzed for ICE and CPP 32 like activity , using N acetyl Tyr Val Ala Asp 7 amino 4 methylcoumarin ( Ac YVAD . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Therefore , the role of interleukin 1 beta converting enzyme ( ICE ) like porteases in p 53 mediated , transcriptionally dependent apoptosis was investigated . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| When apoptosis is induced by cross linking of the Fas / APO 1 / CD95 receptor , activation of interleukin 1beta converting enzyme ( ICE ; caspase 1 ) or ICE like enzymes precedes the disruption of the mitochondrial inner transmembrane potential ( DeltaPsim ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1beta converting enzyme ( ICE ) was the first identified member of a growing family of cysteine proteases that now includes ten mammalian homologs . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The necrotic cell death is also inhibited by inhibitors of ICE ( interleukin 1 beta converting enzyme ) ( like ) proteases , the common mediators of apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The ICE ( Interleukin 1beta Converting Enzyme ) family recently named the caspases for cysteine aspartate specific proteases plays a central role in apoptosis and may well constitute part of the conserved core mechanism of the process . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The present study examined the role of two CRCP families CPP 32 and interleukin 1beta converting enzyme ( ICE ) like cysteine proteases in apoptosis of cerebellar granule cells ( CGCs ) caused by withdrawal of serum and / or potassium ( K+ ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Amyloid beta protein induces necrotic cell death mediated by ICE cascade in PC 12 cells . ^^^ In addition , the interleukin 1beta converting enzyme ( ICE ) subfamily activation preceded CPP 32 subfamily activation during betaAP induced necrotic cell death . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| More detailed investigations of the molecular mechanisms involved in the intracellular apoptotic signal transduction , such as interactions of the bcl 2 and the other members of the bcl 2 family , and functionality of the interleukin 1beta converting enzyme ( ICE ) like proteases , may give new insights into key events responsible for the resistance or sensitivity to the induction of apoptosis in acute leukemia . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We further demonstrated that both EGF and IFN gamma induced caspase 1 ( interleukin 1beta converting enzyme [ ICE ] ) gene expression in a STAT dependent manner . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Fas and tumor necrosis factor receptor 1 ( TNFR 1 ) are membrane proteins that signal for apoptotic cell death by downstream activation of proteins of the interleukin 1 beta converting enzyme ( ICE ) family . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) was originally identified as a novel type of cysteine protease responsible for the conversion of percursor interleukin 1 beta to mature form . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Proteases that are members of the caspase ( or interleukin 1beta converting enzyme ( ICE ) ) protease family have been shown to be important mediators of apoptosis induced by Fas activation , neurotrophic factor withdrawal , and detachment from extracellular matrix . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Cisplatin induced apoptosis of immortalized mouse proximal tubule cells is mediated by interleukin 1 beta converting enzyme ( ICE ) family of proteases but inhibited by overexpression of Bcl 2 . ^^^ Cisplatin induced apoptosis could be inhibited by overexpression of crmA , a cowpox virus gene , of which the product is known to suppress activities of the interleukin 1 beta converting enzyme ( ICE ) family proteases . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In this study , we extend and confirm these observations by using an inhibitor of interleukin 1 beta converting enzyme ( ICE ) homologues . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the involvement of protease activation in these responses using selective peptide inhibitors of the interleukin 1beta converting enzyme ( ICE ) / caspase family and a Ca2+ activated protease we recently implicated in thymocyte apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The involvement of the activation of the interleukin 1 beta converting enzyme ( ICE ) family of proteases ( caspases ) , such as ICE and CPP 32 , in the pathways was also investigated . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| DNA fragmentation associated with necrosis was Ca2+ / Mg2+ dependent , was suppressed by endonuclease inhibitors , and was abolished by serine protease inhibitors but not by inhibitors of interleukin 1 beta converting enzyme ( ICE ) related proteases or caspases . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The effect of several interleukin 1 beta converting enzyme ( ICE ) inhibitors on apoptosis was examined . ^^^ The ICE inhibitors tested were peptide aldehydes such as ethyloxycarbonyl Ala Tyr Val Ala Asp aldehyde ( Etoco AYVAD CHO ) , acetyl Tyr Val Ala Asp aldehyde ( Ac YVAD CHO ) , benzyloxycarbonyl Val His Asp aldehyde ( Z VHD CHO ) , a tetrapeptide chloromethylketone , acetyl Tyr Val Ala Asp chloromethylketone ( Ac YVAD Cmk ) and their common intermediate benzyloxycarbonyl Asp ( beta tertier butyl ester ) bromomethylketone ( Z D ( OtBu ) Bmk ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| High levels of expression and nuclear localization of interleukin 1 beta converting enzyme ( ICE ) and CPP 32 in favorable human neuroblastomas . ^^^ We studied 52 neuroblastic tumors to test whether the cell death related proteases , interleukin 1 beta converting enzyme ( ICE ) , CPP 32 , and Ich 1 , were involved in the regression of the tumors . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We show here that the CED 9 protein is a substrate for the C . elegans cell death protease CED 3 , which is a member of a family of cysteine proteases first defined by CED 3 and human interleukin 1beta converting enzyme ( ICE ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Recent in vitro studies indicate an involvement of members of the interleukin 1beta converting enzyme ( ICE ) family of proteases in programmed neuronal cell death . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Whereas inhibition of caspase activity with the general inhibitor zVAD fmk resulted in a complete block of Fas ligand induced cell death , puromycin mediated apoptosis was found to be unaffected by zVAD fmk as well as by more specific inhibitors for caspase 1 ( Interleukin 1 beta converting enzyme ) and caspase 3 ( CPP32 / Yama ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Probably the best established target of the four is interleukin 1 beta converting enzyme ( ICE ) and Winnie Wong from BASF Bioresearch Corporation presented an overview of work in this field . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| These results suggest that the apoptosis resistant UA cells could have a functional defect in apoptosis signaling from the TNFR to mitochondria and interleukin 1beta converting enzyme ( ICE ) family protease activation . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Thapsigargin , an endoplasmic reticular Ca2+ ATPase inhibitor , induced apoptotic cell death ( chromatin condensation and DNA fragmentation ) accompanied by the activation of CPP 32 like protease , a member of the interleukin 1beta converting enzyme protease ( ICE ) family , but not the activation of ICE like protease . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The Interleukin 1beta converting enzyme ( ICE ) homolog CPP 32 ( Caspase 3 ) was expressed in 10 / 11 breast cell lines . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) is preferentially expressed in neuroblastomas with favourable prognosis . ^^^ To determine whether interleukin 1 beta converting enzyme ( ICE ) plays a role in the programmed cell death of neuroblastoma , we studied ICE expression in primary tumours . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1beta converting enzyme ( ICE ) family proteases ( caspases ) are known to be implicated as important effectors of apoptotic pathways . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| By using chemically induced dimerization , we have developed powerful death switches based on the cysteine proteases , caspase 1 ICE ( interleukin 1beta converting enzyme ) and caspase 3 YAMA . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor 1 analogue prevents apoptosis mediated through an interleukin 1 beta converting enzyme ( caspase 1 ) like protease of cerebellar external granular layer neurons : developmental stage specific mechanisms of neuronal cell death . ^^^ Ac YVAD CHO , an inhibitor of interleukin 1 beta converting enzyme ( caspase 1 ) like proteases , had a protective effect on this apoptosis . ^^^ Interleukin 1 beta converting enzyme ( caspase 1 ) like protease activity increased under the apoptosis induced condition . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Apoptosis involves the activation of a cascade of interleukin 1beta converting enzyme like proteases ( caspases ) , a group of cysteine proteases related to the prototype interleukin 1beta converting enzyme ( caspase 1 ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| When cells were pretreated with the synthesized tetrapeptide inhibitor of caspase , YVAD CHO ( Ac Tyr Val Ala Asp aldehyde : inhibitor of interleukin 1beta converting enzyme ( ICE ) subfamily ) or DEVD CHO ( Ac Asp Glu Val Asp aldehyde : inhibitor of CPP 32 subfamily ) , taxotere induced cell death was prevented . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| At least ten homologues of interleukin 1 beta converting enzyme ( ICE ) , the first described human caspase , have been identified so far . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The molecular link between apoptosis and inflammation is interleukin 1 beta converting enzyme ( ICE ) which is activated during macrophage apoptosis and binds to IpaB , a secreted Shigella protein . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1b converting enzyme ( ICE ) related cysteine proteases are required for E1A induced , p 53 dependent apoptosis in baby rat kidney ( BRK ) cells . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We hypothesized that spinal motor neurons might be lost by apoptosis and investigated a possible mechanism of neuronal death by detection of double strand breaks in genomic DNA and immunohistochemical analysis for caspases , ie , interleukin 1beta converting enzyme ( ICE ) , Nedd 2 , and CPP 32 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The ability of NO to induce apoptosis was completely blocked by a broad spectrum ICE ( interleukin 1beta converting enzyme ) protease / caspase inhibitor and correlated with FLICE / caspase 8 activation . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| These include members of the emerging family of cysteine proteases related to mammalian interleukin 1 beta converting enzyme ( ICE ) and to CED 3 , the product of a gene that is necessary for programmed cell death in the nematode C . elegans . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We found that the frequency of Fas antigen positive cells was higher in PBMC from SIV mac infected macaques than from uninfected controls , and in vitro apoptosis of PBMC was suppressed by an inhibitor of the interleukin 1 beta converting enzyme ( ICE ) family proteases . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In addition , in freshly purified human eosinophils , lavendustin A prevented anti Fas MoAb induced proteolytic cleavage of lamin B , suggesting that tyrosine kinases may amplify the proteolytic signaling cascade within interleukin 1beta converting enzyme ( ICE ) family proteases . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The expression of interleukin 1 beta converting enzyme ( ICE ) in rat is decreased following chronic exposure to morphine . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To determine the cellular expression of Fas , Fas ligand and interleukin 1 beta converting enzyme ( ICE ) in prostatic cancer . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Apoptosis related protein immunoreactivity defined presence and location of Bax , Fas , Fas Ligand ( FasL ) , Bcl 2 , interleukin 1 beta converting enzyme ( ICE ) , inducible nitric oxide synthase ( iNOS ) and the proto oncogene p 53 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The first mammalian homolog of Ced 3 to be described was the Interleukin 1b Converting Enzymes ( ICE ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The objective of the present study was to determine the effects of concanavalin A ( Con A ) administration on the interleukin 1beta converting enzyme ( ICE ) activity and CPP 32 like activity in mouse liver . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Immune system activation induces increase in expression level and enzymatic activity of interleukin 1 beta converting enzyme ( ICE ) in rat brain . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| At least some genes of the cell death pathway have been conserved throughout animal evolution ; ced 3 e ced 9 that regulate the initiation of cellular suicide in the nematode Caenorhabditis elegans are homologous to genes that in mammalian cells are thought to play a similar role ( interleukin 1 beta converting enzyme [ ICE ] family , Bcl 2 ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| F 2 equally hydrolyzed acetyl Asp Glu Val Asp methylcoumarinamide , and acetyl Tyr Val Ala Asp methylcoumarinamide , caspase 1 ( interleukin 1beta converting enzyme ) specific substrate , and was inhibited by acetyl Tyr Val Ala Asp aldehyde and acetyl Tyr Val Ala Asp aldehyde . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The activity of apopain ( CPP 32 ) , an interleukin 1beta converting enzyme ( ICE ) like cysteine protease specifically associated with apoptosis , was increased following dosing with aluminum . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| On the contrary , inhibitors of caspases , proteases belonging to the ICE ( interleukin 1 beta converting enzyme ) family , did not apparently damage granule neurons upon exposure for 24 h to high concentrations ( up to 200 microM ) of two inhibitors specific for ICE ( Ac YAVD CHO ) and CPP 32 ( Ac DEVD CHO ) , respectively . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Both Acetyl Tyr Val Ala Asp chloromethylketone and Acetyl Tyr Val Ala Asp aldehyde , selective caspase 1 ( interleukin 1beta converting enzyme ) inhibitors , exerted only partial protection of cells from apoptosis at higher concentrations . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Casp 1 is activated and its specific substrate interleukin 1beta is cleaved shortly after Shigella infection . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1beta converting enzyme ( ICE ) is required to convert IL 18 precursor protein into its biologically active mature form . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| This activation of caspase 1 is enhanced by oxidative challenge ( xanthine / xanthine oxidase ) , which triggers cleavage and secretion of the interleukin 1beta converting enzyme substrate , pro interleukin 1beta , and induces apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The SPE B induced apoptosis pathway was interleukin 1beta converting enzyme ( ICE ) family protease dependent . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Inhibition of interleukin 1 beta converting enzyme ( ICE ) , apopain , papain , thrombin and trypsin with substrate like peptidyl L and D alpha aldehydes and their L beta homo aldehyde analogues was investigated . ^^^ The L beta homo aspartals appear to be specific inhibitors for ICE and its homologues ; the other enzymes were not inhibited with such L beta homo aldehydes . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| A systematic study of interleukin 1 beta converting enzyme ( ICE , caspase 1 ) and caspase 3 ( CPP 32 , apopain ) inhibitors incorporating a P 2 P3 conformationally constrained dipeptide mimetic is reported . ^^^ Conformationally constrained inhibitors of caspase 1 ( interleukin 1 beta converting enzyme ) and of the human CED 3 homologue caspase 3 ( CPP 32 , apopain ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The human CASP 8 gene , whose product is also known as caspase 8 and FLICE , encodes an interleukin 1beta converting enzyme ( ICE ) related cysteine protease that is activated by the engagement of several different death receptors . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| A three dimensional quantitative structure activity relationship ( QSAR ) study using the comparative molecular field analysis ( CoMFA ) method was performed on a series of interleukin 1 beta converting enzyme ( ICE ) inhibitors . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Peptide based interleukin 1 beta converting enzyme ( ICE ) inhibitors : synthesis , structure activity relationships and crystallographic study of the ICE inhibitor complex . ^^^ Based on the 10 ray structure of the complex of Ac Tyr Val Ala Asp H ( L 709049 ) and interleukin 1 beta converting enzyme ( ICE ) , we synthesized compounds which were derived from 2 NapCO Val Pro Asp CH2OPh ( 1 ) to obtain a potent inhibitor in the cell assay . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Cloning of canine interleukin 18 ( IL 18 ) and canine interleukin 1beta converting enzyme ( ICE ) cDNA was carried out by using murine IL 18 cDNA and human ICE cDNA , respectively , as probes . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| This interaction results in the activation of caspase 1 , as seen in its proteolytic maturation and the processing of its substrate interleukin 1beta . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We found that mutant mice exhibited the typical caspase 1 / phenotype , since they resisted to a lethal injection of LPS and released no interleukin 1beta in the circulation , in contrast to wild type littermates . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 18 and interleukin 1 beta : two cytokine substrates for ICE ( caspase 1 ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The levels of interleukin 1beta converting enzyme ( ICE ) , an activating enzyme , and caspase 3 ( CPP 32 ) , an inactivating enzyme , were assessed to investigate the presence of the appropriate processing enzymes in the cultured cells . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Recently , an involvement of nitric oxide , c Jun amino terminal kinases ( JNK ) and interleukin 1 beta converting enzyme ( ICE ) related proteases has been proposed in KA induced neuronal cell death . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The interleukin 1beta converting enzyme ( ICE ) cysteine protease and 11 other ICE like related proteases have been identified , now named caspases . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In the present study we examined whether transgenic mice expressing a dominant negative inhibitor of interleukin 1beta convertase enzyme ( ICE ) are resistant to MPTP induced neurotoxicity . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Activated caspase 1 ( interleukin 1beta converting enzyme ) and caspase 3 ( Yama / Apopain / Cpp32 ) cleave proteins that are important in maintaining cytoskeletal integrity and DNA repair , and activate deoxyribonucleases , producing cell death with morphological features of apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Many of these signals regulate a family of cysteine proteases related to interleukin 1 beta converting enzyme ( ICE ) caspases which play a crucial role in apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| By Western blot analysis , both the proform and activated form of interleukin 1beta converting enzyme ( caspase 1 ) were detected in the control brain , and the activated form showed moderate reduction after cold injury induced brain trauma . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The beta isoform of interleukin 1 is generated from an inactive , 33 kDa precursor through the action of a specific interleukin 1beta converting enzyme ( ICE ) , also known as caspase 1 . ^^^ Overexpression and increased activity of ICE may contribute to neurodegeneration in AD through generation of biologically active interleukin 1 , with consequent activation of interleukin 1 driven neurodegenerative cascades . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Furthermore , Mn2+ triggered the activation of interleukin 1beta converting enzyme ( ICE / caspase 1 ) , followed by the activation of CPP32 / Yama / Apopain / caspase 3 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Addition of Boc aspartyl ( Ome ) fluoromethyl ketone ( BAF ) , an inhibitor of interleukin 1beta converting enzyme ( ICE ) / caspase proteases , blocked TNF alpha induced reductions in oligodendrocytes , indicating that the TNF alpha induced reduction in oligodendrocytes is , at least in part , due to apoptosis , and that ICE / caspases are one of TNF alpha action mediators . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Molecular cloning of interleukin 1beta from rainbow trout Oncorhynchus mykiss reveals no evidence of an ice cut site . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Apoptosis is mediated by members of the interleukin 1beta converting enzyme ( ICE ) family of proteases ( caspases ) , which are activated by diverse stimuli , although the downstream molecular targets of caspases are still poorly understood . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| METHODS : Both LNCaP and HeLa cells were continuously exposed to clinically achievable concentrations of paclitaxel and observed for activation of programmed cell death as measured by cytotoxic dose response curves , poly ( adenosine diphosphate ribose ) polymerase cleavage , bcl 2 phosphorylation , and the activation of caspase 7 ( interleukin 1 beta converting enzyme ( ICE ) LAP 3 ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| After 1 mM glutamate exposure , a rise of interleukin 1beta converting enzyme ( ICE ) like protease activity in neurons was parallel to cysteine protease p 32 ( CPP 32 ) like protease activity and declined before CPP 32 like protease activity reached the peak ( at 6 h ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| However , it appears certain that the Bcl family of proteins is involved in the apoptotic pathway , and these proteins in turn affect the processing of interleukin 1beta converting enzyme ( ICE ) / caspases . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 ( interleukin 1beta converting enzyme ) is activated and oligonucleosomal DNA fragmentation is detected in traumatized brain tissue . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta converting enzyme ( ICE ) expression and Fas expression in early pregnant villi and their changes following mifepristone administration were detected by immunohistochmical method and computer image analysis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Linkage mapping of the interleukin 1beta converting enzyme ( Il1bc ) and the glutamate receptor subunit KA 1 ( Grik 4 ) genes to rat chromosome 8 . ^^^ Genes for interleukin 1beta converting enzyme ( Il1bc ) and the glutamate receptor subunit KA 1 ( Grik 4 ) have been mapped to a centromeric region of rat chromosome 8 using linkage analysis of HXB and BXH recombinant inbred strains . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 ( interleukin 1beta converting enzyme ) is produced in the form of a latent precursor , which is cleaved to yield a prodomain in addition to the p 20 and p 10 subunits . ^^^ It has been established that the ( p20 / p10 ) ( 2 ) heterotetramer processes the latent precursor of interleukin 1beta into an active form during apoptosis , but the function of the residual prodomain of caspase 1 ( Pro C 1 ) has not been established . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We have synthesized ( acyloxy ) methyl ketone inactivators of papain , cathepsin B , and interleukin 1beta conversion enzyme ( ICE ) that interact with both the S and S ' subsites . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To understand the intracellular regulatory mechanisms in Fas mediated apoptosis of synoviocytes , we examined the involvement of caspases [ caspase 1 / ICE ( interleukin 1beta converting enzyme ) , caspase 3 / CPP32 , and caspase 8 / FLICE ] and Fas associated death domain protein ( FADD ) forming a death inducing signalling complex ( DISC ) in Fas mediated apoptosis of synoviocytes . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Tyr Val Ala Asp chloromethyl ketone , a caspase 1 inhibitor , prevented ATP induced release of processed interleukin 1beta , but not ATP dependent SAPK activity . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The targets of CrmA are members of the caspase family of proteases that either initiate the extrinsic pathway of apoptosis ( caspases 8 and 10 ) or trigger activation of the pro inflammatory cytokines interleukin 1beta and interleukin 18 ( caspase 1 ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To confirm that Interleukin 1 beta converting enzyme ( ICE ) is a first identified apoptosis related gene in mammals . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Only caspase 1 is known to activate interleukin 1beta and interleukin 18 , and caspase 11 activates pro caspase 1 in vivo . ^^^ Caspase 1 subfamily members displayed different in vitro activities toward pro caspases 1 and 3 and pro interleukin 1beta . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 , an interleukin 1beta converting enzyme , has been reported to be related with anti cancer drug induced apoptosis as well as with caspase 3 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| It has been demonstrated that the protease caspase 3 , a downstream molecule of the CD 95 pathway , is activated in UV exposed HaCaT cells , and that the DNA dependent protein kinase catalytic subunit ( DNA PKcs ) is cleaved by interleukin 1beta converting enzyme ( ICE ) like protease during apoptosis induced by 10 rays , staurosporine and etoposide . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the effects of interleukin 1 beta converting enzyme ( ICE ) gene on the biologic characteristics of ovarian cancer cells . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Besides interleukin 1beta , interleukin 18 , a recently described proinflammatory cytokine , is cleaved into its biologically active form by caspase 1 as well . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In addition , it was detected that induction of p 21 ( WAF 1 ) protein and activation of caspase 3 protype , which is one of Interleukin 1beta converting enzyme ( ICE ) family proteases , were detected by Western blotting . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| A series of compounds was designed and prepared as inhibitors of interleukin 1beta converting enzyme ( ICE ) , also known as caspase 1 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Structure based design of nonpeptide inhibitors of interleukin 1beta converting enzyme ( ICE , caspase 1 ) . ^^^ A novel class of reversible inhibitors of Interleukin 1beta converting enzyme ( ICE , caspase 1 ) were discovered by iterative structure based design . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To assess the effect of therapeutic inhibition of interleukin 1beta converting enzyme ( ICE ) in an experimental model of severe acute pancreatitis ( SAP ) . ^^^ In contrast to lung and liver , marked upregulation of interleukin 1beta , tumor necrosis factor alpha , and ICE mRNA was observed in the pancreas , with levels of interleukin 1beta and tumor necrosis factor alpha being reduced in ICE inhibited animals . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Of the 4 cDNA fragments , 2 ( A 1 and D 1 ) did not show sequence homology with the existing genes in the GeneBank , one ( A 2 ) was 89 % homologous with interleukin 1 beta converting enzyme ( ICE ) gene , and the other ( D 2 ) was identical to mouse musculus 45s pre rRNA ( MM45srRNA ) gene . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To detect cell specific apoptosis factors , Fas and Fas ligand , and the common intracellular apoptosis modulators , interleukin 1 beta converting enzyme ( ICE ) like protease ( caspase 1 ) , Bcl 2 , Bcl xL and Bax in lens epithelial cells ( LEC ) of human cataracts . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The time course of caspase 1 mRNA expression paralleled that of interleukin 18 , but not of interleukin 1beta mRNA . ^^^ Their data show spatial and temporal diversity in interleukin 1 and 18 cytokine family expression in brain ischemia , and suggest a role of the interleukin 18 / caspase 1 pathway in late stage inflammatory responses to focal brain ischemia . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 plays a pivotal role in generating mature cytokine interleukin 1beta . ^^^ The upregulation / activation of Caspase 1 was associated with increased levels of interleukin 1beta . ^^^ Depletion of the Caspase 1 gene and pharmacologic blockade of Caspase 1 significantly attenuated the meningitis induced increase in interleukin 1beta . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Of the nearly fourteen mammalian members discovered thus far caspase 1 or ( interleukin 1beta converting enzyme ; ICE ) , and possibly other related family members also serve as activator of cytokines . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Co expression of PYPAF 7 and ASC results in the synergistic activation of caspase 1 and a corresponding increase in secretion of interleukin 1 beta . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Among them , interleukin 1beta converting enzyme ( ICE ) and its family proteases , which are called caspases , play critical roles in the execution stage of apoptosis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In peripheral blood mononuclear cells , inhibition of caspase 1 reduced interleukin 1beta secretion , whereas blockade of phagocytosis inhibited calcium induced apoptosis and interleukin 1beta release . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Amebic lysates have also been shown to activate the precursor to interleukin 1 beta ( proIL 1beta ) , mimicking the action of caspase 1 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Intriguingly , our results demonstrated that inhibitors of the interleukin 1beta converting enzyme subfamily ( caspase 1 , 4 , 5 and 13 ) blocked the butyrate induced increase in level of CD 86 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| In contrast to its effects on Nod 1 and Cardiak dependent NF kappa B activation , CARD 6 did not interfere with caspase 1 dependent interleukin 1 beta secretion induced by Cardiak or Nod 1 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Chicken interleukin 1beta ( ChIL 1beta ) is synthesized as a precursor molecule that unlike its mammalian counterpart , lacks a typical caspase 1 cleavage site . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The caspase 1 and caspase 3 like activities , as well as the level of interleukin 1beta , were significantly reduced in the spinal cord of symptomatic caspase 11 / ; SOD 1 G93A mice compared with that of caspase 11+ / ; SOD 1 G93A mice . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| We are investigating currently the role of NFkappaB during focal cerebral ischemia , using mutant mice deficient in the interleukin 1 converting enzyme gene ( ICE KO ) in a middle cerebral artery occlusion ( MCAO ) model . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To study the effect of pralnacasan , the orally bioavailable pro drug of a potent , non peptide inhibitor of interleukin 1beta converting enzyme ( ICE ) , RU 36384 / VRT 18858 , on joint damage in two mouse models of knee osteoarthritis ( OA ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| EI 1941 1 and 2 , novel interleukin 1 beta converting enzyme ( ICE ) inhibitors , were isolated from the culture broths of Farrowia sp . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Z Asp , an inhibitor of interleukin 1beta converting enzyme ( ICE ) family proteases , inhibited the appearance of the 50 kDa protein and the emergence of the cell free apoptosis activity in the etoposide treated U 937 cytosol . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| AIM : To identify the expression of Caspase 1 ( interleukin 1beta converting enzyme ) and its role in adenoma of the pancreas and chronic pancreatitis . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Serum concentrations of soluble CD 95 ( sCD 95 ) , soluble CD 95 ligand ( sCD95L ; CD 178 ) , tumour necrosis factor ( TNF ) alpha , soluble TNFalpha receptor type 1 ( sTNFR 1 ) , and interleukin 1beta converting enzyme ( ICE ; caspase 1 ) were measured by enzyme linked immunosorbent assay ( ELISA ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| A series of sulfonamides ( 1 ) has been prepared as inhibitors of interleukin 1beta converting enzyme ( ICE ) , also known as caspase 1 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| EI 2128 1 , a novel interleukin 1beta converting enzyme ( ICE ) inhibitor , was isolated from the culture broths of Penicillium sp . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Campylobacter jejuni infection of differentiated THP 1 macrophages results in interleukin 1 beta release and caspase 1 independent apoptosis . ^^^ Inhibition of caspase 1 activity eliminated IL 1 beta processing and secretion , but did not affect apoptosis induction . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| EI 2346 , a novel interleukin 1beta converting enzyme ( ICE ) inhibitor , was isolated from the culture broths of Streptomyces sp . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical studies revealed the expression of Fas ligand ( Fas L ) , Bax and interleukin 1 beta converting enzyme ( ICE ) in the renal tubular epithelium of the descending limb of loop of Henle and the distal convoluted tubules . mRNA of the ICE , c myc , p 53 and Fas L genes was also upregulated in the kidneys of the stone forming rats . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Cryopyrin , the protein that is altered in FCAS , is one of the adaptor proteins that activate caspase 1 , resulting in release of interleukin 1 . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Myocardium specimens were sampled to examine apoptosis related gene interleukin 1 beta converting enzyme ( ICE ) mRNA . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| ApoAlert caspase assay was used for measuring the activity of caspase 3 ( CPP 32 ) and interleukin 1 beta converting enzyme ( ICE ) protease . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Contrary to the proposed anti inflammatory activity of WT pyrin , our results demonstrated that pyrin , like cryopyrin , can also assemble an inflammasome complex with ASC and procaspase 1 leading to ASC oligomerization , caspase 1 activation and interleukin 1beta processing . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 , a cysteine protease is primarily involved in proteolytic activation of proinflammatory cytokines such as interleukin 1beta . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Methylenedioxymethamphetamine increases pro interleukin 1beta production and caspase 1 protease activity in frontal cortex , but not in hypothalamus , of Dark Agouti rats : role of interleukin 1beta in neurotoxicity . 3 , 4 Methylenedioxymethamphetamine ( ecstasy ) increases mature interleukin 1beta production in rat brain shortly after injection . ^^^ Since interleukin 1beta is generated as an inactive 31 kDa precursor protein and processed into mature form by caspase 1 , we have now examined the effect of 3 , 4 methylenedioxymethamphetamine on pro interleukin 1beta production and caspase 1 like protease activity in the hypothalamus and frontal cortex of Dark Agouti rats . 3 , 4 Methylenedioxymethamphetamine increased the immunoreactivity of pro interleukin 1beta in frontal cortex , not in hypothalamus , 3 h and 6 h after administration . ^^^ The basal immunoreactivity of pro interleukin 1beta and caspase 1 like protease activity was higher in the hypothalamus than in frontal cortex of control ( saline treated ) animals . ^^^ These data indicate that 3 , 4 methylenedioxymethamphetamine alters , in a region specific manner , the mechanisms which regulate interleukin 1beta production in the brain of Dark Agouti rats and suggest that the release of interleukin 1beta in hypothalamus may be regulated independently of caspase 1 activation . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Enantio and diastereoselective total synthesis of EI 1941 1 , 2 , and 3 , inhibitors of interleukin 1beta converting enzyme , and biological properties of their derivatives . [ reaction : see text ] The first asymmetric total synthesis of EI 1941 1 , 2 , and 3 , inhibitors of the interleukin 1beta converting enzyme ( ICE ) , has been accomplished , starting from a chiral epoxy iodoquinone 11 , a key intermediate in our total synthesis of epoxyquinols A and B . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| However , it is unknown whether p 38 MAPK mediates the following important events in both myocardial apoptosis and functional depression : mitogen activated protein kinase activated protein kinase 2 , caspase 1 , caspase 3 , and caspase 11 activation , and tumor necrosis factor , interleukin 1beta and interleukin 6 production . ^^^ Myocardial tissue was then assessed for products of p 38 MAPK activation , expression of tumor necrosis factor , interleukin 1beta and interleukin 6 , and activation of caspase 1 , caspase 3 and caspase 11 . ^^^ CONCLUSIONS : The p 38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression : mitogen activated protein kinase activated protein kinase 2 , caspase 1 , caspase 3 and caspase 11 activation , and tumor necrosis factor , interleukin 1beta , interleukin 6 production after myocardial ischemia . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| This paper is a broad overview of the progress that has been achieved so far , with respect to small molecule inhibitor design and pharmacological studies ( in animals and humans ) , for the metalloprotease Tumour Necrosis Factor alpha Converting Enzyme ( TACE ) and the cysteine protease Caspase 1 ( Interleukin 1beta Converting Enzyme , ICE ) . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| CED 3 is a cysteine protease required for programmed cell death in the nematode , Caenorhabditis elegans , and shares a sequence similarity with mammalian ICE ( interleukin 1beta converting enzyme ) family proteases . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Neutrophils process interleukin 1beta and interleukin 18 precursors in a caspase 1 like fashion processing is inhibited by human vascular smooth muscle cells . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Cytosolic flagellin requires Ipaf for activation of caspase 1 and interleukin 1beta in salmonella infected macrophages . ^^^ Gram negative bacteria that replicate in the cytosol of mammalian macrophages can activate a signaling pathway leading to caspase 1 cleavage and secretion of interleukin 1beta , a powerful host response factor . ^^^ Here we demonstrate that salmonella strains either lacking flagellin or expressing mutant flagellin were deficient in activation of caspase 1 and in interleukin 1beta secretion , although transcription factor NF kappaB dependent production of interleukin 6 or the chemokine MCP 1 was unimpaired . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| The recent identification of the inflammasome , a multiprotein complex responsible for interleukin 1beta converting enzyme ( ICE , caspase 1 ) activation , has generated new possibilities for the elucidation of the etiology and pathophysiology of IBD and as a consequence also for the identification of new treatment targets . . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| Synthesis and evaluation of thiazepines as interleukin 1beta converting enzyme ( ICE ) inhibitors . ^^^ A series of monocyclic thiazepine inhibitors of interleukin 1beta converting enzyme ( ICE ) were synthesized in eight steps from commercially available intermediates . ^^^ |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P29466 |
Pubmed |
SVM Score :0.0 |
| NA |
|