Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.61950069
This soluble IL 1 receptor protein from COS 1 cells was purified to homogeneity by affinity chromatography using recombinant IL 1beta as the ligand and shown to have an affinity for human 125I IL 1beta ( KD approximately 2 3 nM ) comparable to the human type 2 IL 1 receptor ( IL 1RII ) . 0.61950069^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Binding of iodinated IL 1 beta was evaluated by autoradiography on cytosmears of IL 1RII positive B cell lines RAJI , the RAJI clone 1H7 , and STS 25 . ^^^ Results obtained suggest an heterogeneity of IL 1RII expression within the B cell population , with only 5 to 16 % of the cells able to bind IL 1 beta . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
IL 1 beta binds to IL 1RI and to IL 1RII through different sites , and the loop 164 173 appears as one of the areas involved in the selective interaction with IL 1RI . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Specifically , there are no reports to date characterizing IL 1R 2 detection by enzyme linked immunoassay in the presence of IL 1 beta or characterizing IL 1 beta detection in the presence of IL 1R 2 . ^^^ This study addresses the detection and quantitation of IL 1R 2 and IL 1 beta by a number of sandwich ELISA formats and characterizes the sensitivity of detection in the presence of competitive cytokines . ^^^ In this context , a 4 : 1 molar ratio of IL 1 beta to IL 1R 2 interferes with the IL 1R 2 detection by the M22 / R2 but not the M2 / R2 ELISA . ^^^ Conversely , IL 1R 2 at physiologically relevant concentrations interferes with the detection of IL 1 beta by three distinct IL 1 beta ELISA formats . ^^^ Taken together , these studies suggest that when measuring samples that may contain both IL 1 beta and IL 1R 2 , careful attention must be given to assay specificity . . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
This down regulation of the IL 1 beta gene in sepsis PMN occurs concomitant with an upregulation in the constitutive expression of the type 2 IL 1 receptor ( IL 1R2 ) . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
These data indicate that IL 1RII mediates the central effects of a low dose of IL 1 beta , but not IL 1 alpha , on fever and thermogenesis in the rat . ^^^ They also imply that responses to endotoxin are due , at least in part , to the activation of IL 1RII by IL 1 beta released within the brain and that effects of peripherally injected IL 1 beta involve different mechanisms , probably associated with IL 1RI . . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
First , neutralizing antibodies to IL 1RI but not IL 1RII drastically abrogated cell survival induced by IL 1 beta in CD34+ / Lin cells and TF 1 cells . ^^^ IL 1RII does not appear to be involved in signal transduction in primary CD34+ / Lin cells but could negatively regulate the response to IL 1 beta in TF 1 cells . . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
In the present report , plasma IL 1beta , IL 1ra , and soluble IL 1RI and IL 1RII concentrations were evaluated in 118 patients with sepsis syndrome or after elective operative trauma . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Interleukin 1 alpha ( IL 1 alpha ) and IL 1 beta bind to either the p 80 type 1 IL 1 receptor ( IL 1RI ) or the p 68 type 2 IL 1R ( IL 1RII ) on both T and B lymphocytes . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
IL 1 beta induced profiles of IL 1 beta , IL 1 receptor type 1 and 2 ( IL 1RI and IL 1RII ) , and IL 1 receptor antagonist ( 2 1Ra ) mRNAs were highly intercorrelated in the same samples . ^^^ The data suggest the operation of an IL 1 beta feedback system ( IL 1 beta / IL 1RI / IL 1RII / IL 1Ra ) within a brain region . ^^^ The fine regulation of the CNS IL 1 beta system may depend on a balance between the ligand ( IL 1 beta ) action on the IL 1RI and the induction of inhibitory mechanisms ( IL 1RII and IL 1Ra ) . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
CONCLUSIONS : Differential expression of IL 1 beta , IL 1ra , IL 1RI , and IL 1RII mRNAs after focal stroke may suggest a distinct role ( s ) for each component of the IL 1 system in ischemic injury . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
In contrast , the binding affinity to the type 2 IL 1R ( IL 1RII ) is the same as that of wild type IL 1 beta . ^^^ The results show that 1 ) loop 7 is part of the binding site of IL 1 beta to IL 1RI , but not to IL 1RII . 2 ) The structure of the mutant protein is not grossly altered except locally at the position of the substituted loop . 3 ) The substitution of amino acids by site directed mutagenesis of the loop 7 region generates mutants with binding affinity constants slightly lower than that of wild type IL 1 beta and not comparable to that of the loop substitution analogue . 4 . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
The combination of endotoxin and dexamethasone induces type 2 interleukin 1 receptor ( IL 1r 2 ) in monocytes : a comparison to interleukin 1 beta ( IL 1 beta ) and interleukin 1 receptor antagonist ( IL 1ra ) . ^^^ Soluble type 2 interleukin 1 receptor ( IL 1r 2 ) and interleukin 1 receptor antagonist ( IL 1ra ) regulate inflammation by competitively inhibiting the binding of IL 1 beta to the signalling IL 1 receptor . ^^^ Therefore , LPS and dexamethasone synergism in IL 1r 2 induction may be important in controlling IL 1 beta effects . ^^^ Although IL 1r 2 and IL 1ra may work together to suppress IL 1 beta effects in sepsis , inflammatory cells differentially regulate these cytokines . . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
The mRNA levels of the secreted IL 1ra isoform , but not intracellular IL 1raI and 2 , and IL 1RII were elevated in PP EC and paralleled those of IL 1beta . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Transient transfection of COS cells with the cloned bovine IL 1rII cDNA resulted in specific binding of bovine IL 1 beta , with a Kd of 1 . 82 10 10 ( 10 ) M . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Conversely , binding of IL 1beta to IL 1RII bearing cells could be inhibited by DoB 0041 much less efficiently than by wild type IL 1ra . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
The present study was carried out to test the hypotheses that ( 1 ) cellular secretion of interleukin 1 beta ( IL 1 beta ) , interleukin 1 receptor antagonist ( IL 1Ra ) , and soluble interleukin 1 receptor type 2 ( IL 1sRII ) is abnormal in female CFS patients compared to age and activity matched controls ; ( 2 ) that these abnormalities may be evident only at certain times in the menstrual cycle ; and ( 3 ) that physical exertion ( stepping up and down on a platform for 15 min ) may accentuate differences between these groups . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
IL 1beta increased IL 1beta , IL 1 receptor types 1 and 2 ( IL 1RI and IL 1RII ) , IL 1 receptor accessory protein soluble form ( IL 1R AcP 2 ) , IL 1 receptor antagonist ( IL 1Ra ) , TNF alpha , and TGF beta 1 mRNAs in the hypothalamus from obese and lean rats . ^^^ The data suggest 1 ) the operation of an IL 1beta feedback system ( IL 1beta / IL 1RI / IL 1R Acp II / IL 1RII / IL 1Ra ) and 2 ) potential cytokine cytokine interactions with positive ( IL 1beta < > TNF alpha ) and negative ( TGF beta 1 > IL 1beta / TNF alpha ) feedback . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
The expression of IL 1beta , IL 1 Receptor 1 ( IL 1R1 ) , Il 1R2 , IL 1R antagonist ( IL 1Ra ) , and ICE mRNA within the pancreas was examined by quantitative differential RT PCR . ^^^ There was constitutive expression of pancreatic IL 1R1 , IL 1R2 , IL 1Ra , and ICE but not IL 1beta . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
To study their functionality in the brain , mice were centrally treated with neutralizing monoclonal antibody ( MAb ) directed against IL 1RI ( 35F5 , 1 microgram ) or against IL 1RII ( 4E2 , 2 micrograms ) and were centrally injected with recombinant rat IL 1 beta at a dose ( 2 ng ) that decreased social exploration . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
We describe the inducible expression of the two agonists , IL 1 alpha ( 31 kDa and 17 kDa ) and IL 1 beta ( 17 kDa ) and of the IL 1 receptor subtypes IL 1RI and IL 1RII in the brain and in the adrenals ( as well as in the pituitary cell line AtT 20 ) . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
The interleukin 1 family consists of three ligands ( IL 1 alpha , IL 1 beta , and the IL 1 receptor antagonist ) and two receptors ( IL 1RI and IL 1RII ) . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Shedding of IL 1RII yields the soluble IL 1 receptor type 2 ( IL 1sRII ) which retains the ability of membrane bound IL 1RII to bind IL 1beta avidly , but binds IL 1Ra and IL 1alpha with low affinity . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
In the present study , the levels of soluble IL 1 receptor type 2 ( sIL 1R type 2 ) , IL 1 receptor antagonist ( IL 1ra ) , IL 1beta , IL 6 and TNF alpha were analyzed in cerebrospinal fluid ( CSF ) samples from Alzheimer ' s disease patients and control subjects . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
IL 1beta induced chemokine production and release were inhibited by a 10 to 1 , 000 fold molar excess of recombinant IL 1RII or IL 1Ra , whereas IL 1RI was a less effective inhibitor . ^^^ On the basis of our results , we propose that human lung epithelial cells lack the ability to downregulate IL 1beta activity extracellularly because of an inability to express IL 1RII . ^^^ Release of extracellular IL 1 inhibitors , including soluble IL 1Ra and soluble IL 1RII , by other inflammatory cells present in the airway may be critical for regulation of IL 1beta activity in the airway microenvironment . . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
In response to TNFalpha stimulation , messenger RNA ( mRNA ) levels for the IL 1 receptor 1 ( IL 1RI ) , IL 1RII , TNF receptor 2 ( TNFR 2 ) , and IL 6 receptor as well as the level of proinflammatory cytokines , such as IL 1alpha , IL 1beta , lymphotoxin beta , TNFalpha , and IL 6 , also increased . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Cross linking and affinity binding studies reveal that IL 1beta exclusively binds the type 1 receptor ( IL 1RI ) and not IL 1RII in both HT 29 / p and HT 29 / MTX cells . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Our present study investigated the expression of IL 1beta , IL 1 receptor antagonist ( IL 1ra ) , and IL 1 receptor ( IL 1RI and IL 1RII ) mRNA in carotid artery after balloon angioplasty using semiquantitative reverse transcription / polymerase chain reaction ( RT / PCR ) and Northern analysis . ^^^ The expression of IL 1RII mRNA was remarkably similar to that of IL 1beta , whereas the IL 1RI ( the signaling receptor ) mRNA expression was delayed ( significantly induced at day 1 ; 14 . 2 fold increase , P < 0 . 01 ) post balloon injury . ^^^ The differential but concomitant expression of IL 1beta , IL 1ra , IL 1RI , and IL 1RII mRNAs after balloon angioplasty suggests that each of these IL 1 system components may play a distinct role in neointima formation . . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
IL 1beta induced changes in hypothalamic IL 1R1 and IL 1R2 mRNA expression in the rat . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Conversely , cells overexpressing wtIL 1RII ( 811 ) or uIL 1RII ( 9D4 ) showed comparable reduction in responsiveness to both IL 1alpha ( bound by membrane and soluble receptors ) and IL 1beta ( recognized by the membrane receptor only ) , suggesting that the membrane form of the IL 1RII is mainly responsible for IL 1 inhibition . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Functional genomic analyses showed that soluble ( s ) IL 1RII , at picomolar concentrations , but not soluble TNF receptor : Fc , significantly inhibited IL 1beta induced nitric oxide ( NO ) and / or prostaglandin E ( 2 ) production in chondrocytes , synovial and epithelial cells . ^^^ Human chondrocytes that overexpressed IL 1RII were resistant to IL 1 induced IL 1beta mRNA accumulation and inhibition of proteoglycan synthesis . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Over expression of IL 1RII on HGFs by gene transfer down regulated the expression of IL 1 beta mRNA and IL 6 mRNA in response to IL 1 beta stimulation , while the expression of IL 8 mRNA was not affected . ^^^ In the IL 1RII transfected HGFs , phosphorylation of 25 and 74 kDa proteins was up regulated upon IL 1 beta stimulation in the transfected HGFs . ^^^ These results suggest that the IL 1RII may regulate HGFs expression of cytokine mRNA upon IL 1 beta stimulation , possibly by altering the IL 1RI dependent signals . . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
We previously reported that IL 1beta and the decoy receptor for IL 1 ( IL 1RII ) are expressed by intestinal epithelial cells ( IEC ) during detachment induced cell death , or `` anoikis . ' ' We now investigated whether IL 1 regulates anoikis . ^^^ Skewing the balance in favor of IL 1 , by blocking IL 1RII or by adding IL 1beta to detached rat IEC 18 cells , reduced cell death . ^^^ The protective effect of anti IL 1RII was reversed by blocking IL 1beta , confirming the anti apoptotic effect was due to endogenous IL 1beta . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Using RT PCR , we first showed that the expression of IL 1RI and IL 1RII , but not IL 1RacP , mRNAs are up regulated by IL 1 beta in a time dependent manner . ^^^ IL 1 beta decreases the number of IL 1RI binding sites , whereas it increases those of IL 1RII . ^^^ IL 4 and IL 10 both up regulate IL 1RII IL 1 beta induced , but only IL 4 does so for IL 1RI . ^^^ At the protein level , IL 4 and IL 10 dramatically reverse the ability of IL 1 beta to inhibit expression of IL 1RI but neither affects the ability of IL 1 beta to enhance the number of IL 1RII . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
The IL 1RII ( + ) ( but not IL 1RII ( ) ) cells were resistant to IL 1beta induced , NO , PGE ( 2 ) , IL 6 , and IL 8 production or decreased proteoglycan synthesis . ^^^ IL 1RII ( + ) chondrocytes were more resistant to induction of NO and PGE ( 2 ) by IL 1beta compared with IL 1RII ( ) cells incubated with a 10 fold ( weight ) excess of soluble type 2 IL 1R ( sIL 1RII ) protein . ^^^ In cocultures , IL 1RII ( + ) synovial cells released sIL 1RII , which in a paracrine fashion protected chondrocytes from the effects of IL 1beta . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
The IL 1 family consists of two agonists , IL 1alpha and IL 1beta , two receptors , biologically active IL 1RI and inert IL 1RII , and a specific receptor antagonist , IL 1Ra . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURE ( S ) : MCP 1 secretion in the culture medium and serum concentrations of soluble IL 1 receptor type 2 ( sIL 1RII ) , IL 1beta , and IL 1alpha by ELISA or by enzyme immunometric assay . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Bacterial lipopolysaccharide ( LPS ) caused increased expression of IL 1RI , IL 1RII and IL 1RAcP mRNAs , induced the release of IL 1beta , IL 6 and prostaglandin E 2 ( PGE 2 ) , and activated nuclear factor kappaB ( NF kappaB ) and the mitogen activated protein kinases ( MAPKs ) p 38 , and extracellular signal regulated protein kinase ( ERK1 / 2 ) , but not c Jun N terminal kinase ( JNK ) in microglial cultures . ^^^ Interestingly , a neutralizing antibody to IL 1RII significantly increased the concentration of IL 1beta in the medium of LPS treated microglia and exacerbated the IL 1beta induced IL 6 release in mixed glia , providing the first evidence that microglial IL 1RII regulates IL 1beta actions by binding excess levels of this cytokine during brain inflammation . . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Pointing to the potentially underlying mechanism of increased IL 1 beta stimulated IL 8 secretion in HT 29 cells , butyrate up regulated IL 1RI mRNA but not IL 1RII . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
In addition to IL 1beta , IL 6 , TNF alpha , and their receptors , LEW / N hypothalamic cells also transcribed more anti inflammatory molecules , IL 1RII , IL 1RA , and transforming growth factor ( TGFbeta 1 ) , than F334 / N cells . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Levels of CAM components aggrecan and type 2 collagen ( CII ) and levels of intracellular IGF 1 , IL 1alpha , and IL 1beta and their respective plasma membrane bound receptors IGFRI , IL 1 receptor 1 ( IL 1RI ) , and the decoy receptor IL 1RII were assayed using flow cytometry to investigate the relationship between the autocrine / paracrine pathways and the homeostasis of ECM molecules in the CAM . ^^^ Interestingly , levels of aggrecan and CII in the CAM strongly correlated not only with IGF 1 , but also with IL 1RII , which acts as a decoy receptor for IL 1alpha and IL 1beta . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Our data indicate that CGA and IL 1RI are expressed by all seven , IL 1 beta by five , IL 1RII and IL 1RA by six lines . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
The aim of the present work was to investigate the expression of IL 1alpha , IL 1beta , IL 1ra , IL 1R1 , and IL 1R2 genes in equine cumulus cells and oocytes . ^^^ Our results indicated that equine oocytes expressed IL 1beta and IL 1R2 genes , and that cumulus cells expressed all IL 1 system members except IL 1alpha . ^^^ In conclusion , we demonstrated for the first time , in mares , the presence of IL 1beta and IL 1R2 transcripts in oocytes and of IL 1beta , IL 1ra , IL 1R1 , and IL 1R2 in cumulus cells . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
RESULTS : We demonstrated that interleukin 1beta ( IL 1beta ) , interleukin 1 receptor 2 ( IL 1R2 ) and interleukin 1 receptor antagonist ( IL 1RA ) genes are expressed in equine granulosa cells . ^^^ We observed that the IL 1beta and IL 1RA mRNA content changed in granulosa cells during the terminal follicular maturation whereas IL 1R2 mRNA did not vary . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Specific gene expression of the pro inflammatory cytokine IL 1beta and the type 2 IL 1beta receptor ( IL 1RII , ' decoy receptor ' ) was studied in skin of rainbow trout Oncorhynchus mykiss ( Walbaum , 1792 ) fry during infection with the ectoparasitic monogenean Gyrodactylus derjavini Mikailov , 1975 . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Further , increased IL 1RII shedding by ARTS 1 overexpressing cells attenuates the biological activity of IL 1beta . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
We have analysed transcripts of IL 1 gene system ( IL 1alpha , IL 1beta , IL 1RI , IL 1RII and IL 1RA ) to evaluate the possible link between the level of gene ( s ) transcription and their function . ^^^ Looking more closely at gene ( s ) differential expression it appears that IL 1alpha can be preferentially down regulated by IL 1RA gene in intratubular fraction while the IL 1beta , through the `` false ' ' IL 1RII receptor in the interstitium . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
In previous reports , we have demonstrated the expression of IL 1 receptors ( IL 1RI and IL 1RII ) and enhancing effects of IL 1beta on primary human megakaryocytic ( MK ) cells . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
RESULTS : Lipopolysaccharide and zymosan stimulated TNF alpha , IL 1beta , and IL 10 production ; and peritoneal fluids from both control animals and animals with zymosan induced peritonitis stimulated the production of TNF alpha , IL 1RII , and IL 6 . ^^^ The decoy molecule IL 1 receptor type 2 ( IL 1RII ) was produced at the same time as IL 1beta and production of the anti inflammatory cytokine IL 10 was evident within 4 h . ^^^ The anti inflammatory molecules IL 1RII and IL 10 are induced at the same time as the pro inflammatory cytokines TNF alpha , IL 1beta , and IL 6 . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Here we have investigated the expression of IL 1beta , IL 1RI and IL 1RII in distinct inflammatory lesions in the rat brain . ^^^ In contrast , although IL 1beta and IL 1RI were elevated to similar levels in response to NMDA challenge , the response was delayed and IL 1RII mRNA expression was unchanged . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
At varying times , peritoneal mesothelial cells from animals undergoing lavage had greater up regulation ( P < 0 . 05 ) of mRNA expression for TNFalpha , IL 1beta , GROalpha , and ICAM 1 and greater production ( P < 0 . 05 ) of TNFalpha , IL 1RII , GROalpha , and ICAM 1 . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
IL 1RI , IL 1RII , and IL 1Ra were all up regulated , whereas the IL 1beta converting enzyme , caspase 1 , and IRAK M were down regulated . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Recombinant equine soluble IL 1RI and IL 1RII produced in insect cells bound recombinant equine IL 1alpha and IL 1beta . ^^^ Furthermore , both receptors suppressed the growth inhibitory activities of equine IL 1alpha and IL 1beta toward A 375 cells in a dose dependent manner , indicating that the present equine IL 1RI and IL 1RII cDNA encodes biologically active proteins . . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Significant correlation was observed between the levels of colostral IL 1beta and IL1R2 ( r=0 . 75 ) . . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
VS also inhibited LPS dependent up regulation of IL 1beta and IL 6 mRNA in the brain , while increasing by 50 % the cerebral expression of transcripts of the specific antagonist of IL 1 receptors IL 1RA and IL 1R2 . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
These findings show a high expression of IL 1beta and its functional receptor ( IL 1RI ) in FCD and GNT specimens together with a relative paucity of mechanisms ( IL 1RII and IL 1Ra ) apt to inactivate IL 1beta actions . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
For this reason , cytokine receptor expression by placental and uterine cells using immunohistology and flow cytometry has been investigated , those being : IGF 1r , PDGF r alpha / beta , IL 1rII , IL 6r , IL 7r , IFN gamma r , TNF rp 80 and endoglin . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Increased circulating cytokine receptors and ex vivo interleukin 1 receptor antagonist and interleukin 1beta production but decreased tumour necrosis factor alpha production after a 5 km run . ^^^ Although plasma interleukin 6 ( IL 6 ) was undetectable and soluble interleukin 1 receptor type 2 ( IL 1sRII ) remained unchanged , interleukin 1 receptor antagonist ( IL 1ra ) concentrations were elevated directly after the race with a further increase at 3 h ( P < 0 . 0001 ) . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
Of the genes affected by all three arsenicals , only one , that coding for interleukin 1 receptor , type 2 , showed enhanced expression , a finding confirmed by the reduced increase in NF kappaB ( nuclear factor kappa B ) activity seen in response to interleukin 1beta in iAs ( 3 ) exposed cells . ^^^
Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P01584 and P27930	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.61950069
This soluble IL 1 receptor protein from COS 1 cells was purified to homogeneity by affinity chromatography using recombinant IL 1beta as the ligand and shown to have an affinity for human 125I IL 1beta ( KD approximately 2 3 nM ) comparable to the human type 2 IL 1 receptor ( IL 1RII ) . 0.61950069^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Specifically , there are no reports to date characterizing IL 1R 2 detection by enzyme linked immunoassay in the presence of IL 1 beta or characterizing IL 1 beta detection in the presence of IL 1R 2 . ^^^ This study addresses the detection and quantitation of IL 1R 2 and IL 1 beta by a number of sandwich ELISA formats and characterizes the sensitivity of detection in the presence of competitive cytokines . ^^^ In this context , a 4 : 1 molar ratio of IL 1 beta to IL 1R 2 interferes with the IL 1R 2 detection by the M22 / R2 but not the M2 / R2 ELISA . ^^^ Conversely , IL 1R 2 at physiologically relevant concentrations interferes with the detection of IL 1 beta by three distinct IL 1 beta ELISA formats . ^^^ Taken together , these studies suggest that when measuring samples that may contain both IL 1 beta and IL 1R 2 , careful attention must be given to assay specificity . . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
The combination of endotoxin and dexamethasone induces type 2 interleukin 1 receptor ( IL 1r 2 ) in monocytes : a comparison to interleukin 1 beta ( IL 1 beta ) and interleukin 1 receptor antagonist ( IL 1ra ) . ^^^ Soluble type 2 interleukin 1 receptor ( IL 1r 2 ) and interleukin 1 receptor antagonist ( IL 1ra ) regulate inflammation by competitively inhibiting the binding of IL 1 beta to the signalling IL 1 receptor . ^^^ Therefore , LPS and dexamethasone synergism in IL 1r 2 induction may be important in controlling IL 1 beta effects . ^^^ Although IL 1r 2 and IL 1ra may work together to suppress IL 1 beta effects in sepsis , inflammatory cells differentially regulate these cytokines . . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURE ( S ) : MCP 1 secretion in the culture medium and serum concentrations of soluble IL 1 receptor type 2 ( sIL 1RII ) , IL 1beta , and IL 1alpha by ELISA or by enzyme immunometric assay . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Of the genes affected by all three arsenicals , only one , that coding for interleukin 1 receptor , type 2 , showed enhanced expression , a finding confirmed by the reduced increase in NF kappaB ( nuclear factor kappa B ) activity seen in response to interleukin 1beta in iAs ( 3 ) exposed cells . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Binding of iodinated IL 1 beta was evaluated by autoradiography on cytosmears of IL 1RII positive B cell lines RAJI , the RAJI clone 1H7 , and STS 25 . ^^^ Results obtained suggest an heterogeneity of IL 1RII expression within the B cell population , with only 5 to 16 % of the cells able to bind IL 1 beta . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
IL 1 beta binds to IL 1RI and to IL 1RII through different sites , and the loop 164 173 appears as one of the areas involved in the selective interaction with IL 1RI . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
This down regulation of the IL 1 beta gene in sepsis PMN occurs concomitant with an upregulation in the constitutive expression of the type 2 IL 1 receptor ( IL 1R2 ) . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
The present study was carried out to test the hypotheses that ( 1 ) cellular secretion of interleukin 1 beta ( IL 1 beta ) , interleukin 1 receptor antagonist ( IL 1Ra ) , and soluble interleukin 1 receptor type 2 ( IL 1sRII ) is abnormal in female CFS patients compared to age and activity matched controls ; ( 2 ) that these abnormalities may be evident only at certain times in the menstrual cycle ; and ( 3 ) that physical exertion ( stepping up and down on a platform for 15 min ) may accentuate differences between these groups . ^^^ Interleukin 1 beta , interleukin 1 receptor antagonist , and soluble interleukin 1 receptor type 2 secretion in chronic fatigue syndrome . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Increased circulating cytokine receptors and ex vivo interleukin 1 receptor antagonist and interleukin 1beta production but decreased tumour necrosis factor alpha production after a 5 km run . ^^^ Although plasma interleukin 6 ( IL 6 ) was undetectable and soluble interleukin 1 receptor type 2 ( IL 1sRII ) remained unchanged , interleukin 1 receptor antagonist ( IL 1ra ) concentrations were elevated directly after the race with a further increase at 3 h ( P < 0 . 0001 ) . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Shedding of IL 1RII yields the soluble IL 1 receptor type 2 ( IL 1sRII ) which retains the ability of membrane bound IL 1RII to bind IL 1beta avidly , but binds IL 1Ra and IL 1alpha with low affinity . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
In the present study , the levels of soluble IL 1 receptor type 2 ( sIL 1R type 2 ) , IL 1 receptor antagonist ( IL 1ra ) , IL 1beta , IL 6 and TNF alpha were analyzed in cerebrospinal fluid ( CSF ) samples from Alzheimer ' s disease patients and control subjects . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
In contrast , the binding affinity to the type 2 IL 1R ( IL 1RII ) is the same as that of wild type IL 1 beta . ^^^ The results show that 1 ) loop 7 is part of the binding site of IL 1 beta to IL 1RI , but not to IL 1RII . 2 ) The structure of the mutant protein is not grossly altered except locally at the position of the substituted loop . 3 ) The substitution of amino acids by site directed mutagenesis of the loop 7 region generates mutants with binding affinity constants slightly lower than that of wild type IL 1 beta and not comparable to that of the loop substitution analogue . 4 . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
These data indicate that IL 1RII mediates the central effects of a low dose of IL 1 beta , but not IL 1 alpha , on fever and thermogenesis in the rat . ^^^ They also imply that responses to endotoxin are due , at least in part , to the activation of IL 1RII by IL 1 beta released within the brain and that effects of peripherally injected IL 1 beta involve different mechanisms , probably associated with IL 1RI . . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
First , neutralizing antibodies to IL 1RI but not IL 1RII drastically abrogated cell survival induced by IL 1 beta in CD34+ / Lin cells and TF 1 cells . ^^^ IL 1RII does not appear to be involved in signal transduction in primary CD34+ / Lin cells but could negatively regulate the response to IL 1 beta in TF 1 cells . . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
In the present report , plasma IL 1beta , IL 1ra , and soluble IL 1RI and IL 1RII concentrations were evaluated in 118 patients with sepsis syndrome or after elective operative trauma . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Interleukin 1 alpha ( IL 1 alpha ) and IL 1 beta bind to either the p 80 type 1 IL 1 receptor ( IL 1RI ) or the p 68 type 2 IL 1R ( IL 1RII ) on both T and B lymphocytes . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
IL 1 beta induced profiles of IL 1 beta , IL 1 receptor type 1 and 2 ( IL 1RI and IL 1RII ) , and IL 1 receptor antagonist ( 2 1Ra ) mRNAs were highly intercorrelated in the same samples . ^^^ The data suggest the operation of an IL 1 beta feedback system ( IL 1 beta / IL 1RI / IL 1RII / IL 1Ra ) within a brain region . ^^^ The fine regulation of the CNS IL 1 beta system may depend on a balance between the ligand ( IL 1 beta ) action on the IL 1RI and the induction of inhibitory mechanisms ( IL 1RII and IL 1Ra ) . ^^^ IL 1 beta induced profiles of IL 1 beta , IL 1 receptor type 1 and 2 ( IL 1RI and IL 1RII ) , and IL 1 receptor antagonist ( 2 1Ra ) mRNAs were highly intercorrelated in the same samples . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
CONCLUSIONS : Differential expression of IL 1 beta , IL 1ra , IL 1RI , and IL 1RII mRNAs after focal stroke may suggest a distinct role ( s ) for each component of the IL 1 system in ischemic injury . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
The mRNA levels of the secreted IL 1ra isoform , but not intracellular IL 1raI and 2 , and IL 1RII were elevated in PP EC and paralleled those of IL 1beta . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Transient transfection of COS cells with the cloned bovine IL 1rII cDNA resulted in specific binding of bovine IL 1 beta , with a Kd of 1 . 82 10 10 ( 10 ) M . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
For this reason , cytokine receptor expression by placental and uterine cells using immunohistology and flow cytometry has been investigated , those being : IGF 1r , PDGF r alpha / beta , IL 1rII , IL 6r , IL 7r , IFN gamma r , TNF rp 80 and endoglin . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Conversely , binding of IL 1beta to IL 1RII bearing cells could be inhibited by DoB 0041 much less efficiently than by wild type IL 1ra . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
IL 1beta increased IL 1beta , IL 1 receptor types 1 and 2 ( IL 1RI and IL 1RII ) , IL 1 receptor accessory protein soluble form ( IL 1R AcP 2 ) , IL 1 receptor antagonist ( IL 1Ra ) , TNF alpha , and TGF beta 1 mRNAs in the hypothalamus from obese and lean rats . ^^^ The data suggest 1 ) the operation of an IL 1beta feedback system ( IL 1beta / IL 1RI / IL 1R Acp II / IL 1RII / IL 1Ra ) and 2 ) potential cytokine cytokine interactions with positive ( IL 1beta < > TNF alpha ) and negative ( TGF beta 1 > IL 1beta / TNF alpha ) feedback . ^^^ IL 1beta increased IL 1beta , IL 1 receptor types 1 and 2 ( IL 1RI and IL 1RII ) , IL 1 receptor accessory protein soluble form ( IL 1R AcP 2 ) , IL 1 receptor antagonist ( IL 1Ra ) , TNF alpha , and TGF beta 1 mRNAs in the hypothalamus from obese and lean rats . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
The expression of IL 1beta , IL 1 Receptor 1 ( IL 1R1 ) , Il 1R2 , IL 1R antagonist ( IL 1Ra ) , and ICE mRNA within the pancreas was examined by quantitative differential RT PCR . ^^^ There was constitutive expression of pancreatic IL 1R1 , IL 1R2 , IL 1Ra , and ICE but not IL 1beta . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
To study their functionality in the brain , mice were centrally treated with neutralizing monoclonal antibody ( MAb ) directed against IL 1RI ( 35F5 , 1 microgram ) or against IL 1RII ( 4E2 , 2 micrograms ) and were centrally injected with recombinant rat IL 1 beta at a dose ( 2 ng ) that decreased social exploration . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
We describe the inducible expression of the two agonists , IL 1 alpha ( 31 kDa and 17 kDa ) and IL 1 beta ( 17 kDa ) and of the IL 1 receptor subtypes IL 1RI and IL 1RII in the brain and in the adrenals ( as well as in the pituitary cell line AtT 20 ) . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
The interleukin 1 family consists of three ligands ( IL 1 alpha , IL 1 beta , and the IL 1 receptor antagonist ) and two receptors ( IL 1RI and IL 1RII ) . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
IL 1beta induced chemokine production and release were inhibited by a 10 to 1 , 000 fold molar excess of recombinant IL 1RII or IL 1Ra , whereas IL 1RI was a less effective inhibitor . ^^^ On the basis of our results , we propose that human lung epithelial cells lack the ability to downregulate IL 1beta activity extracellularly because of an inability to express IL 1RII . ^^^ Release of extracellular IL 1 inhibitors , including soluble IL 1Ra and soluble IL 1RII , by other inflammatory cells present in the airway may be critical for regulation of IL 1beta activity in the airway microenvironment . . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
In response to TNFalpha stimulation , messenger RNA ( mRNA ) levels for the IL 1 receptor 1 ( IL 1RI ) , IL 1RII , TNF receptor 2 ( TNFR 2 ) , and IL 6 receptor as well as the level of proinflammatory cytokines , such as IL 1alpha , IL 1beta , lymphotoxin beta , TNFalpha , and IL 6 , also increased . ^^^ In contrast , treatment with transforming growth factor beta 1 ( TGFbeta 1 ) resulted in down regulation of matrix metalloproteinase 1 ( MMP 1 ) and MMP 13 concomitant with a reduction in the levels of mRNA for IL 1RI , IL 1RII , TNFRI , and TNFRII and proinflammatory cytokine levels . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Cross linking and affinity binding studies reveal that IL 1beta exclusively binds the type 1 receptor ( IL 1RI ) and not IL 1RII in both HT 29 / p and HT 29 / MTX cells . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Our present study investigated the expression of IL 1beta , IL 1 receptor antagonist ( IL 1ra ) , and IL 1 receptor ( IL 1RI and IL 1RII ) mRNA in carotid artery after balloon angioplasty using semiquantitative reverse transcription / polymerase chain reaction ( RT / PCR ) and Northern analysis . ^^^ The expression of IL 1RII mRNA was remarkably similar to that of IL 1beta , whereas the IL 1RI ( the signaling receptor ) mRNA expression was delayed ( significantly induced at day 1 ; 14 . 2 fold increase , P < 0 . 01 ) post balloon injury . ^^^ The differential but concomitant expression of IL 1beta , IL 1ra , IL 1RI , and IL 1RII mRNAs after balloon angioplasty suggests that each of these IL 1 system components may play a distinct role in neointima formation . . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
IL 1beta induced changes in hypothalamic IL 1R1 and IL 1R2 mRNA expression in the rat . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Conversely , cells overexpressing wtIL 1RII ( 811 ) or uIL 1RII ( 9D4 ) showed comparable reduction in responsiveness to both IL 1alpha ( bound by membrane and soluble receptors ) and IL 1beta ( recognized by the membrane receptor only ) , suggesting that the membrane form of the IL 1RII is mainly responsible for IL 1 inhibition . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Functional genomic analyses showed that soluble ( s ) IL 1RII , at picomolar concentrations , but not soluble TNF receptor : Fc , significantly inhibited IL 1beta induced nitric oxide ( NO ) and / or prostaglandin E ( 2 ) production in chondrocytes , synovial and epithelial cells . ^^^ Human chondrocytes that overexpressed IL 1RII were resistant to IL 1 induced IL 1beta mRNA accumulation and inhibition of proteoglycan synthesis . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Over expression of IL 1RII on HGFs by gene transfer down regulated the expression of IL 1 beta mRNA and IL 6 mRNA in response to IL 1 beta stimulation , while the expression of IL 8 mRNA was not affected . ^^^ In the IL 1RII transfected HGFs , phosphorylation of 25 and 74 kDa proteins was up regulated upon IL 1 beta stimulation in the transfected HGFs . ^^^ These results suggest that the IL 1RII may regulate HGFs expression of cytokine mRNA upon IL 1 beta stimulation , possibly by altering the IL 1RI dependent signals . . ^^^ The type 2 interleukin 1 receptor ( IL 1RII ) has been thought to be incapable of transducing signals to cells because of its short intracellular domain , while type 1 IL 1 receptor ( IL 1RI ) does transduce signals . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Our data indicate that CGA and IL 1RI are expressed by all seven , IL 1 beta by five , IL 1RII and IL 1RA by six lines . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
The aim of the present work was to investigate the expression of IL 1alpha , IL 1beta , IL 1ra , IL 1R1 , and IL 1R2 genes in equine cumulus cells and oocytes . ^^^ Our results indicated that equine oocytes expressed IL 1beta and IL 1R2 genes , and that cumulus cells expressed all IL 1 system members except IL 1alpha . ^^^ In conclusion , we demonstrated for the first time , in mares , the presence of IL 1beta and IL 1R2 transcripts in oocytes and of IL 1beta , IL 1ra , IL 1R1 , and IL 1R2 in cumulus cells . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
The IL 1 family consists of two agonists , IL 1alpha and IL 1beta , two receptors , biologically active IL 1RI and inert IL 1RII , and a specific receptor antagonist , IL 1Ra . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
We previously reported that IL 1beta and the decoy receptor for IL 1 ( IL 1RII ) are expressed by intestinal epithelial cells ( IEC ) during detachment induced cell death , or `` anoikis . ' ' We now investigated whether IL 1 regulates anoikis . ^^^ Skewing the balance in favor of IL 1 , by blocking IL 1RII or by adding IL 1beta to detached rat IEC 18 cells , reduced cell death . ^^^ The protective effect of anti IL 1RII was reversed by blocking IL 1beta , confirming the anti apoptotic effect was due to endogenous IL 1beta . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Using RT PCR , we first showed that the expression of IL 1RI and IL 1RII , but not IL 1RacP , mRNAs are up regulated by IL 1 beta in a time dependent manner . ^^^ IL 1 beta decreases the number of IL 1RI binding sites , whereas it increases those of IL 1RII . ^^^ IL 4 and IL 10 both up regulate IL 1RII IL 1 beta induced , but only IL 4 does so for IL 1RI . ^^^ At the protein level , IL 4 and IL 10 dramatically reverse the ability of IL 1 beta to inhibit expression of IL 1RI but neither affects the ability of IL 1 beta to enhance the number of IL 1RII . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
The IL 1RII ( + ) ( but not IL 1RII ( ) ) cells were resistant to IL 1beta induced , NO , PGE ( 2 ) , IL 6 , and IL 8 production or decreased proteoglycan synthesis . ^^^ IL 1RII ( + ) chondrocytes were more resistant to induction of NO and PGE ( 2 ) by IL 1beta compared with IL 1RII ( ) cells incubated with a 10 fold ( weight ) excess of soluble type 2 IL 1R ( sIL 1RII ) protein . ^^^ In cocultures , IL 1RII ( + ) synovial cells released sIL 1RII , which in a paracrine fashion protected chondrocytes from the effects of IL 1beta . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
In addition to IL 1beta , IL 6 , TNF alpha , and their receptors , LEW / N hypothalamic cells also transcribed more anti inflammatory molecules , IL 1RII , IL 1RA , and transforming growth factor ( TGFbeta 1 ) , than F334 / N cells . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Levels of CAM components aggrecan and type 2 collagen ( CII ) and levels of intracellular IGF 1 , IL 1alpha , and IL 1beta and their respective plasma membrane bound receptors IGFRI , IL 1 receptor 1 ( IL 1RI ) , and the decoy receptor IL 1RII were assayed using flow cytometry to investigate the relationship between the autocrine / paracrine pathways and the homeostasis of ECM molecules in the CAM . ^^^ Interestingly , levels of aggrecan and CII in the CAM strongly correlated not only with IGF 1 , but also with IL 1RII , which acts as a decoy receptor for IL 1alpha and IL 1beta . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
RESULTS : We demonstrated that interleukin 1beta ( IL 1beta ) , interleukin 1 receptor 2 ( IL 1R2 ) and interleukin 1 receptor antagonist ( IL 1RA ) genes are expressed in equine granulosa cells . ^^^ We observed that the IL 1beta and IL 1RA mRNA content changed in granulosa cells during the terminal follicular maturation whereas IL 1R2 mRNA did not vary . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Bacterial lipopolysaccharide ( LPS ) caused increased expression of IL 1RI , IL 1RII and IL 1RAcP mRNAs , induced the release of IL 1beta , IL 6 and prostaglandin E 2 ( PGE 2 ) , and activated nuclear factor kappaB ( NF kappaB ) and the mitogen activated protein kinases ( MAPKs ) p 38 , and extracellular signal regulated protein kinase ( ERK1 / 2 ) , but not c Jun N terminal kinase ( JNK ) in microglial cultures . ^^^ Interestingly , a neutralizing antibody to IL 1RII significantly increased the concentration of IL 1beta in the medium of LPS treated microglia and exacerbated the IL 1beta induced IL 6 release in mixed glia , providing the first evidence that microglial IL 1RII regulates IL 1beta actions by binding excess levels of this cytokine during brain inflammation . . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Pointing to the potentially underlying mechanism of increased IL 1 beta stimulated IL 8 secretion in HT 29 cells , butyrate up regulated IL 1RI mRNA but not IL 1RII . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Specific gene expression of the pro inflammatory cytokine IL 1beta and the type 2 IL 1beta receptor ( IL 1RII , ' decoy receptor ' ) was studied in skin of rainbow trout Oncorhynchus mykiss ( Walbaum , 1792 ) fry during infection with the ectoparasitic monogenean Gyrodactylus derjavini Mikailov , 1975 . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Further , increased IL 1RII shedding by ARTS 1 overexpressing cells attenuates the biological activity of IL 1beta . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
We have analysed transcripts of IL 1 gene system ( IL 1alpha , IL 1beta , IL 1RI , IL 1RII and IL 1RA ) to evaluate the possible link between the level of gene ( s ) transcription and their function . ^^^ Looking more closely at gene ( s ) differential expression it appears that IL 1alpha can be preferentially down regulated by IL 1RA gene in intratubular fraction while the IL 1beta , through the `` false ' ' IL 1RII receptor in the interstitium . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
In previous reports , we have demonstrated the expression of IL 1 receptors ( IL 1RI and IL 1RII ) and enhancing effects of IL 1beta on primary human megakaryocytic ( MK ) cells . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
RESULTS : Lipopolysaccharide and zymosan stimulated TNF alpha , IL 1beta , and IL 10 production ; and peritoneal fluids from both control animals and animals with zymosan induced peritonitis stimulated the production of TNF alpha , IL 1RII , and IL 6 . ^^^ The decoy molecule IL 1 receptor type 2 ( IL 1RII ) was produced at the same time as IL 1beta and production of the anti inflammatory cytokine IL 10 was evident within 4 h . ^^^ The anti inflammatory molecules IL 1RII and IL 10 are induced at the same time as the pro inflammatory cytokines TNF alpha , IL 1beta , and IL 6 . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Here we have investigated the expression of IL 1beta , IL 1RI and IL 1RII in distinct inflammatory lesions in the rat brain . ^^^ In contrast , although IL 1beta and IL 1RI were elevated to similar levels in response to NMDA challenge , the response was delayed and IL 1RII mRNA expression was unchanged . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
At varying times , peritoneal mesothelial cells from animals undergoing lavage had greater up regulation ( P < 0 . 05 ) of mRNA expression for TNFalpha , IL 1beta , GROalpha , and ICAM 1 and greater production ( P < 0 . 05 ) of TNFalpha , IL 1RII , GROalpha , and ICAM 1 . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
IL 1RI , IL 1RII , and IL 1Ra were all up regulated , whereas the IL 1beta converting enzyme , caspase 1 , and IRAK M were down regulated . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Recombinant equine soluble IL 1RI and IL 1RII produced in insect cells bound recombinant equine IL 1alpha and IL 1beta . ^^^ Furthermore , both receptors suppressed the growth inhibitory activities of equine IL 1alpha and IL 1beta toward A 375 cells in a dose dependent manner , indicating that the present equine IL 1RI and IL 1RII cDNA encodes biologically active proteins . . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
Significant correlation was observed between the levels of colostral IL 1beta and IL1R2 ( r=0 . 75 ) . . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
VS also inhibited LPS dependent up regulation of IL 1beta and IL 6 mRNA in the brain , while increasing by 50 % the cerebral expression of transcripts of the specific antagonist of IL 1 receptors IL 1RA and IL 1R2 . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
These findings show a high expression of IL 1beta and its functional receptor ( IL 1RI ) in FCD and GNT specimens together with a relative paucity of mechanisms ( IL 1RII and IL 1Ra ) apt to inactivate IL 1beta actions . ^^^
Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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Interacting proteins: P27930 and P01584	Pubmed	SVM Score :0.0
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