| Interacting proteins: P01584 and P24158 |
Pubmed |
SVM Score :0.0 |
| The presence of C ANCA and cytokines ( IL 1 beta and TNF alpha ) is important in the pathogenesis of vasculitis and GN in WG . . ^^^ |
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| Interacting proteins: P01584 and P24158 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : EC were cultured in 96 well plates and stimulated with TNF alpha and IL 1beta for 1 h to induce membrane expression of endothelial PR 3 . ^^^ |
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| Interacting proteins: P01584 and P24158 |
Pubmed |
SVM Score :0.0 |
| The results showed that trauma amplified the activity of peritoneal macrophage , but inhibited Orphanin FQ and its receptor NP 4 transcripts in the central nervous system , in the mean time , IL 1beta transcripts in the central nervous system was also augmented . ^^^ |
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| Interacting proteins: P01584 and P24158 |
Pubmed |
SVM Score :0.0 |
| We concluded that anti PR 3 antibodies are potent inducers of monocyte cytokine and prostanoid release , and TNF alpha , IL 1beta , and TxA 2 function as facilitators of the secretory response . ^^^ |
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| Interacting proteins: P01584 and P24158 |
Pubmed |
SVM Score :0.0 |
| METHODS : Polymerase chain reaction and restriction fragment length polymorphism analyses were performed to determine polymorphisms in the IL 1beta and IL 1ra genes in 79 patients with PR 3 ANCA , 30 patients with MPO ANCA vasculitis , and 196 healthy controls . ^^^ RESULTS : The frequency of the so called proinflammatory genotype , characterized by high secretion of IL 1beta and low secretion of its antagonist IL 1ra , was increased significantly in patients with PR 3 ANCA with end stage renal disease . ^^^ CONCLUSION : Patients with a renal manifestation of PR 3 ANCA vasculitis have an increased risk for developing end stage renal disease when carrying the proinflammatory IL 1beta / IL 1ra genotype . ^^^ |
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| Interacting proteins: P01584 and P24158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P24158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P24158 |
Pubmed |
SVM Score :0.0 |
| NA |
|