Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.53199118
IL 1beta binds to s IL1R with a 1 : 1 stoichiometry . 0.53199118^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.56619479
This IL 1b effect was completely blocked by cotreatment with IL 1RA , thereby suggesting mediation via a specific IL 1 receptor . 0.56619479^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.58640825
In a similar manner , the potencies of the two sources of IL 1Ra were compared when human synovial fibroblasts were challenged with IL 1beta produced constitutively by genetically modified cells . 0.58640825^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
After 2 h of stimulation with human recombinant IL 1 alpha or IL 1 beta , the levels of T cell / fibroblast type IL 1R mRNA increased , and the elevation was sustained for at least 72 h . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RESULTS : The level of IL 1 beta mRNA expression was elevated in the group with stage 1 endometriosis , whereas the increased expression of IL 1ra mRNA was observed in the group with stages 3 and 4 endometriosis . ^^^ The level of IL 1 beta mRNA showed a positive correlation with that of IL 1 beta in PF and a negative correlation with the level of IL 1ra mRNA . ^^^ CONCLUSIONS : Our results suggest that peritoneal macrophages express IL 1ra mRNA rather than IL 1 beta mRNA with the progress of endometriosis and that peritoneal macrophages may secrete IL 1ra protein that modulates the effects of IL 1 . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the AML blast colony culture assay , sIL 1R and IL 1RA inhibited blast colony forming cell replication in a dose dependent fashion , at concentrations ranging from 10 to 500 ng / mL ( sIL 1R ) and 10 to 1 , 000 ng / mL ( IL 1RA ) , and their inhibitory effect was partially reversed by IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
They constitutively secrete a high amount of IL 1ra and little or no IL 1 alpha or IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Maximal expressions of IL 1 beta and IL 1Ra mRNA in LPS stimulated monocytes were observed 2 h and 8 h , respectively , after stimulation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Binding was strictly temperature dependent , was not saturable and could be inhibited by excess amounts of unlabelled 163 171 peptide but not by IL 1 beta , suggesting that the 163 171 fragment is not an IL 1R binding domain of IL 1 beta . ^^^ It is concluded that the active domain 163 171 of IL 1 beta can be taken up by cells through a receptor independent , temperature dependent mechanisms and that its ability to activate cellular functions is based on IL 1R independent intracellular pathways . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Although IL 1 beta and IL 1Ra are both LPS inducible genes , they displayed distinct temporal patterns of expression . ^^^ Peak steady state mRNA levels for IL 1ra lagged significantly behind that of IL 1 beta , suggesting a possible endogenous mechanism for limiting IL 1 biologic activity . ^^^ Furthermore , although IL 4 suppressed expression of both IL 1 beta and IL 6 , it up regulated synthesis of IL 1ra mRNA and protein . ^^^ Thus , IL 4 inhibits production of the proinflammatory cytokine , IL 1 beta , while concomitantly enhancing synthesis of the IL 1ra in activated human monocytes . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Human dermal fibroblast interleukin 1 receptor antagonist ( IL 1ra ) and interleukin 1 beta ( IL 1 beta ) mRNA and protein are co stimulated by phorbol ester : implication for a homeostatic mechanism . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Because cytokines are thought to contribute to the pathogenesis of chronic arthritis , we investigated the effect of the Lyme disease spirochete , Borrelia burgdorferi , on the gene expression and synthesis of IL 1 beta and the IL 1 receptor antagonist ( IL 1ra ) in human peripheral blood mononuclear cells . ^^^ Live B . burgdorferi induced fivefold more IL 1 beta than IL 1 alpha and sevenfold more IL 1 beta than IL 1ra ; LPS or sonicated B . burgdorferi induced similar amounts of all three cytokines . ^^^ The marked induction of IL 1 beta was partially diminished by heat treatment and abrogated by sonication ; IL 1ra was not affected . ^^^ IL 1 beta synthesis increased in response to increasing numbers of spirochetes , whereas IL 1ra synthesis did not . ^^^ The preferential induction by B . burgdorferi of IL 1 beta over IL 1ra is an example of excess agonist over antagonist synthesis induced by a microbial pathogen , and may contribute to the destructive lesion of Lyme arthritis . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Human IL 1 receptor antagonist ( IL 1ra ) is structurally related to IL 1 alpha and IL 1 beta but binds to IL 1 receptors on various target cells without demonstrable agonist activity . ^^^ The effects of lipopolysaccharide ( LPS ) on IL 1 alpha , IL 1 beta and IL 1ra production was studied at a single cell level by use of cytokine specific antibodies and indirect immunofluorescence technique . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
A naturally occurring IL 1 specific receptor antagonist ( IL 1ra ) , which shares 40 % conserved amino acid homology with IL 1 beta , binds to IL 1 surface receptors with the same affinity as IL 1 but does not possess agonist activity and acts as a competitive inhibitor of IL 1 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Plasma tumor necrosis factor ( TNF ) and IL 1 beta levels were unaffected , whereas serum C reactive protein ( CRP ) concentrations increased slightly and plasma IL 1 receptor antagonist ( IL 1RA ) levels increased markedly . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In contrast , i . p . or intracerebroventricular administration of IL 1ra blocked the depressive effect of IL 1 beta on food motivated behavior and social exploration when this cytokine was administered by the same route as the antagonist . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
A human recombinant interleukin 1 receptor antagonist ( IL 1ra ) recognizes the two known IL 1 receptors and blocks the binding and many biological effects of both IL 1 alpha and IL 1 beta . ^^^ Based on our previous finding that preadministration of antiserum to IL 1 beta markedly suppressed plasma IL 6 after LPS , and recent evidence that molar excesses of IL 1ra blocked IL 1 induced circulating IL 6 levels , the possibility that IL 1 is responsible for the induction of bioactive IL 6 during inflammation can not be ruled out . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Those areas also express the genes encoding interleukin 1 alpha ( IL 1 alpha ) , IL 1 beta , IL 1 receptors , and IL 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The inhibitor has no cross reactivity against a panel of known cytokines ( IL 1 alpha , IL 1 beta , IL 2 , sIL 2R , IL 6 , tumor necrosis factor ( TNF ) , interferon gamma ( IFN gamma ) ) and is distinct from the IL 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In competition studies , IL 1ra , recombinant human IL 1 alpha , IL 1 beta and a weak IL 1 beta analog inhibited [ 125I ] IL 1ra binding to mouse tissues in parallel with their biological activities . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Local injection of a recombinant human IL 1 receptor antagonist ( IL 1Ra ) caused a dose dependent inhibition of local inflammatory responses initiated by human and rabbit IL 1 alpha s well as rabbit IL 1 beta indicating the species cross reactivity of the antagonist . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Evidence showing that IL 1 plays a role in antibacterial resistance early in listeriosis was obtained through the use of 35F5 mAb that binds to the murine type 1 IL 1R and functions to block IL 1 alpha and IL 1 beta actions . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
This study was undertaken , therefore , to investigate whether IL 1ra may block the IL 1 alpha and IL 1 beta effects on the firing rates ( FR ) of W and C neurons in guinea pig POA slices . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The plasma IL 1 beta and IL 6 responses to lethal E . coli septic shock were also significantly diminished by IL 1ra treatment ( P less than 0 . 05 ) , whereas tumor necrosis factor alpha ( TNF alpha ) concentrations were unaffected . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 receptor antagonist ( IL 1ra ) , a naturally occurring polypeptide with amino acid sequence homology to interleukin 1 alpha ( IL 1 alpha ) and interleukin 1 beta ( IL 1 beta ) , prevents Escherichia coli induced shock and death . ^^^ IL 1 beta and IL 1ra were measured by specific RIAs . ^^^ IL 4 alone ( 0 . 01 100 ng / ml ) did not stimulate IL 1 beta synthesis but rather induced IL 1ra ( 4 . 82 + / 0 . 94 ng / ml ) . ^^^ LPS induced synthesis of both IL 1 beta ( 6 . 67 + / 1 . 06 ng / ml ) and IL 1ra ( 10 . 77 + / 2 . 79 ng / ml ) . ^^^ In human peripheral blood mononuclear cells stimulated with IL 1 alpha , IL 4 markedly suppressed IL 1 beta production but enhanced IL 1ra synthesis greater than 2 fold . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Recombinant human ( rh ) IL 1Ra is structurally similar to IL 1 beta but with no IL 1 like activity , and specifically binds to the IL 1 receptor . ^^^ The inhibitory effect exerted by IL 1Ra on human PBMC IL 1 mRNA transcription and the down regulation of secretion of IL 1 beta stimulated by IL 1 alpha , may contribute to therapeutic effects in inflammatory diseases such as rheumatoid arthritis and other autoimmune diseases . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Recently an interleukin 1 receptor antagonist ( IL 1ra ) has been discovered , which is secreted by human macrophages and is structurally similar to IL 1 beta ( 26 % homology ) . ^^^ The enhancing effect of IL 1ra on IL 2 activity was similar to that provoked by IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 receptor antagonist ( IL 1ra ) is a 22 Kd protein that shares homology with IL 1 beta , binds to the IL 1 receptor , but has no known agonist properties . ^^^ However , in animals that eventually succumb to septic shock , Il 1ra appears in quantities presumed inadequate to block the pathologic sequelae associated with high IL 1 beta levels . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1ra alone at concentrations as high as 1 microgram / mL did not induce IL 1 alpha , IL 1 beta , TNF alpha , or IL 6 synthesis . ^^^ A 10 fold molar excess of IL 1ra over IL 1 beta reduced IL 1 beta induced IL 1 alpha by 95 % ( P = . 01 ) and IL 1 alpha induced IL 1 beta by 73 % ( P less than . 01 ) . ^^^ IL 1ra added to PBMC 8 hours after stimulation with IL 1 beta was still able to inhibit IL 1 alpha , TNF alpha , and IL 6 synthesis ( P less than or equal to . 01 ) . ^^^ In elutriated monocytes , a 10 fold molar excess of IL 1ra reduced IL 1 beta induced IL 1 alpha by 82 % ( P less than . 05 ) , TNF alpha by 64 % ( P = . 05 ) , and IL 6 by 47 % ( P less than . 05 ) . 125I IL 1 beta was bound to purified monocytes , cross linked , and immunoprecipitated . ^^^ Excess unlabeled IL 1 beta or IL 1ra blocked the binding of 125I IL 1 beta to the IL 1RtII . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
However , this phenomenon was not specific for LPS ; 1 microgram / mL IL 1ra inhibited IL 1 beta synthesized in response to human recombinant IL 2 by 44 % ( P less than . 001 ) , toxic shock syndrome toxin 1 by 26 % ( P less than . 05 ) , and phorbol 12 myristate 13 acetate by 76 % ( P less than . 001 ) . ^^^ IL 1ra added to PBMC 4 or 8 hours after stimulation with LPS still inhibited IL 1 beta synthesis by 44 % ( P less than . 001 ) or 25 % ( P = . 01 ) , respectively . ^^^ The steady state messenger RNA levels of IL 1 beta were reduced in PBMC stimulated by LPS in the presence of IL 1ra . ^^^ In monocytes isolated by elutriation , IL 1ra reduced LPS induced IL 1 alpha by 16 % ( P less than . 001 ) , IL 1 beta by 14 % ( P less than . 05 ) , and TNF alpha by 24 % ( P = . 01 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1R on 70Z / 3 and splenic B cells bound human IL 1 alpha , murine IL 1 alpha , and murine IL 1 beta with high affinity at both 4 degrees and 37 degrees C . ^^^ In contrast , the affinity of IL 1R on these same cell types for human IL 1 beta was significantly reduced at 37 degrees C compared to 4 degrees C . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Cultured human granulosa and theca cells did not contain mRNA for IL 1 beta or IL 1RA but did contain mRNA for IL 1R . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In contrast , the IL 1ra failed to inhibit the formation of cross linked complexes of 125I labeled bovine IL 1 beta and its receptor . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To examine the roles of endogenous IL 1 alpha and IL 1 beta , anti rat IL 1 alpha antiserum ( anti IL 1 alpha ) and a recombinant human IL 1 receptor antagonist ( IL 1ra ) were used as specific blockers for IL 1 alpha and IL 1 beta , respectively . ^^^ IL 1ra ( 10 micrograms ) completely blocked LH suppression induced by 1 microgram IL 1 beta , but did not completely reverse the changes of LH induced by 5 micrograms LPS . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Peak plasma concentrations of IL 1ra were about a hundred fold greater than those of IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
These results suggest that the soluble IL 1 beta binding protein is a proteolytically cleaved form of the novel B cell IL 1R . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
These data implicate IL 1 beta in CML disease progression and suggest that the inhibitory effects of molecules such as sIL 1R and IL 1RA could conceivably be the basis of a novel therapeutic strategy against this disorder . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1Ra was equally effective at inhibiting IL 1 alpha or IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Recombinant IL 1 beta induced neutrophil emigration into the lung was inhibited by 95 % when IL 1ra was coinjected intratracheally with IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
These results with IL 1ra K145D demonstrate the importance of the region surrounding the corresponding Asp 145 residue in IL 1 beta for triggering the biological response to IL 1 . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Cytokines , such as IL 1 alpha ( 1 ng / ml ) and IL 1 beta ( 1 ng / ml ) , were found to reduce the chondrocyte IL 1R level by about 78 % versus the control . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Equilibrium binding and kinetic experiments show that IL 1ra binds to the 80 kDa IL 1 receptor on the murine thymoma cell line EL 4 with an affinity ( KD = 150 pM ) approximately equal to that of IL 1 alpha and IL 1 beta for this receptor . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Human IL 1ra has some sequence identity to human IL 1 beta , but the evolutionary relationship between these proteins has been unclear . ^^^ We show that the genes for human , mouse , and rat IL 1ra are similar to the genes for IL 1 alpha and IL 1 beta in intron exon organization , indicating that gene duplication events were important in the creation of this gene family . ^^^ Furthermore , an analysis of sequence comparisons and mutation rates for IL 1 alpha , IL 1 beta , and IL 1ra suggests that the duplication giving rise to the IL 1ra gene was an early event in the evolution of the gene family . ^^^ Comparisons between the mature sequences for IL 1ra , IL 1 alpha , and IL 1 beta suggest that IL 1ra has a beta stranded structure like to IL 1 alpha and IL 1 beta , consistent with the three proteins being related . ^^^ The N terminal sequences of IL 1ra appear to be derived from a region of the genome different than those of IL 1 alpha and IL 1 beta , thus explaining their different modes of biosynthesis and suggesting an explanation for their different biological activities . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
This ELISA was specific for IL 1ra ; there was no detection of IL 1 alpha , IL 1 beta , or lysozyme . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1ra is a glycoprotein structurally similar to IL 1 beta but having no interleukin 1 like activity . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Mouse IL 1Ra is a 22 Kd glycoprotein that is 76 % identical to its human counterpart , shows considerably less similarity to IL 1 alpha and IL 1 beta , and competes with IL 1 alpha for binding to the type 1 IL 1 receptor normally expressed on T cells and fibroblasts . ^^^ CSF 1 treatment of mouse bone marrow derived macrophages led to a rapid and sustained increase in IL 1Ra mRNA during the G 1 phase of the cell cycle as well as to increases in mRNAs encoding IL 1 alpha and IL 1 beta . ^^^ Cycloheximide inhibited CSF 1 induced IL 1 alpha mRNA synthesis , but augmented IL 1 beta mRNA production and did not affect induction of IL 1Ra mRNA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The binding of 125I IL 1 beta to PMN was competively inhibited by IL 1ra . ^^^ IL 1 beta was more potent in inhibiting the binding of 125I IL 1 beta than IL 1ra . ^^^ Incubating PMN with 125I IL 1ra in the presence of increasing concentrations of IL 1 beta or IL 1ra showed that IL 1 beta was an approximately 40 fold more potent inhibitor of binding of 125I IL 1ra than unlabeled IL 1ra . ^^^ IL 1ra was also able to competitively inhibit binding of 125I IL 1 beta to Raji cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We studied the relationship between the production of the 23 Kd interleukin 1 receptor antagonist ( IL 1ra ) and IL 1 beta in cultures of human peripheral blood mononuclear cells ( PBMC ) using a specific radioimmunoassay for IL 1ra that had a sensitivity of 166 + / 11 pg / mL . ^^^ PBMC cultured without human serum made little IL 1ra or IL 1 beta . ^^^ In the presence of 1 % AB serum , there was no increase in IL 1 beta ( 0 . 25 + / 0 . 13 ng / mL ) but IL 1ra production increased sevenfold to 3 . 4 + / 0 . 5 ng / mL . ^^^ IgG ( 2 . 5 to 100 micrograms / mL IgG ) or granulocyte macrophage colony stimulating factor ( GM CSF ) ( 1 to 100 ng / mL ) had no significant effect on IL 1 beta production but increased IL 1ra production up to 18 fold ( 18 . 2 + / 3 . 9 ng / mL ) . ^^^ Using endotoxin as a stimulant , 82 % + / 2 % of IL 1ra was secreted in comparison with 52 % + / 9 % of IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Human monocytes may synthesize simultaneously both the agonist IL 1 beta and a specific receptor antagonist of IL 1 ( IL 1ra ) . ^^^ IL 1ra and IL 1 beta protein levels in cell supernatants and lysates were measured with specific ELISA . ^^^ Monocytes stimulated with LPS produced near equivalent amounts of IL 1ra and IL 1 beta proteins over 22 h ; relative steady state mRNA levels paralleled the protein levels . ^^^ In addition , LPS induced monocytes exhibited enhanced rates of transcription for both IL 1ra and IL 1 beta , in comparison to adherent control cells without LPS . mRNA half lives in LPS induced monocytes also were similar for IL 1ra and IL 1 beta . ^^^ These results indicate that production of IL 1ra by human monocytes is characterized by different patterns of regulation in comparison with IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Binding of IL 1 beta to IL 1R type 2 at single cell level . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Human IL 1ra binds to the receptors on the human B cells with an affinity ( KD = 15 + / 3 nM ) equal to that of IL 1 alpha and only 15 fold lower than that of IL 1 beta and , likewise , binds to human PMNs with an affinity ( KD = 8 + / 4 nM ) 15 fold lower than that of IL 1 beta . ^^^ Human IL 1ra binds very weakly to the type 2 receptor on the mouse pre B cells with an affinity ( KD = 1 . 4 + / 0 . 2 microM ) about 1500 fold lower than human IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Because of the potential importance of interleukin 1 ( IL 1 ) in modulating inflammation and the observations that human blood neutrophils ( PMN ) express IL 1 receptors ( IL 1R ) and synthesize IL 1 alpha and IL 1 beta , we studied the IL 1R on blood PMN from a group of patients with the sepsis syndrome . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Binding was found to be displaceable by mature human and murine IL 1 beta and human 31 kD IL 1 beta propeptide , but not displaceable by human and murine IL 1 alpha or human IL 1 receptor ( IL 1R ) antagonist . ^^^ Measurement of binding affinity of the cell surface Raji IL 1R ( Kd = 2 . 2 nm ) and the Raji soluble ( s ) IL 1R ( Kd = 2 . 7 nm ) demonstrated a similar affinity for 125I IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Culture supernatants of unstimulated leukemic cells contained IL 1 beta and granulocyte macrophage CSF ( GM CSF ) , but when incubated with the IL 1ra , a reduction or disappearance of GM CSF was observed in 8 of 10 cases , whereas spontaneous IL 1 production was reduced in four of seven cases . ^^^ By Northern hybridization , IL 1 beta gene transcripts were shown in 20 of 23 AML cases , whereas IL 1ra specific messenger RNA was present in only two of the patients studied . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Using site specific mutagenesis , we have identified the binding site on IL 1 beta for the murine type 1 IL 1R . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We have now shown that intravenous injection of IL 1ra into rabbits given an intra articular injection of recombinant IL 1 beta not only inhibits the entry of leukocytes into the synovial lining and joint cavity but blocks the ability of IL 1 to cause loss of proteoglycan from articular cartilage . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Like the type 1 receptor , the human type 2 IL 1 receptor can bind all three forms of IL 1 ( IL 1 alpha , IL 1 beta and IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Recently it has been reported that human macrophages not only secrete interleukin 1 ( IL 1 ) but also its inhibitor , called IL 1 receptor antagonist ( IL 1ra ) , structurally similar to IL 1 beta , but with no IL 1 like activity and which binds to the IL 1 receptor . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
An anti inflammatory function of IL 1 is also indicated from data showing that IL 1ra treatment limited to 6 h or less after the induction of reactivation enhances joint swelling , whereas intravenous injection of human recombinant IL 1 beta 24 h before reactivation suppresses the reactivation of arthritis . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The RRA is based on the competition between human 125I labeled rIL 1 alpha and standard or unknown quantities of IL 1 alpha or IL 1 beta for binding to a limited amounts of IL 1 receptor ( IL 1R ) isolated from the EL 4 mouse thymoma cell line . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The effect of the naturally occurring IL 1 receptor antagonist protein ( IL 1ra ) on fibroblast transcription is distinct from that of the IL 1 beta R G mutein , for the IL 1ra fails to stimulate not only late ( procollagenase and prostromelysin ) but also immediate early ( fos and jun ) gene expression . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Finally , the fragment in position 163 171 appears to be responsible for a restricted series of the IL 1 beta activities , mainly directed to the immune system , although irrelevant for inflammation related effects and unable of binding to the IL 1R . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The recombinant IL 1ra also blocks IL 1 alpha and IL 1 beta stimulation of PGE 2 production in human synovial cells and rabbit articular chondrocytes , and of collagenase production by the synovial cells . ^^^ A 50 % inhibition of these IL 1 induced biological responses requires amounts of IL 1ra up to 100 fold in excess of the amounts of IL 1 alpha or IL 1 beta present . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1R on murine T cells is a Mr = 80 , 000 plasma membrane glycoprotein . cDNA cloning and transfection experiments have shown that this is an integral membrane protein , which binds both IL 1 alpha and IL 1 beta and transduces the IL 1 signal . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
On the other hand , crosslinking studies with [ 125I ] IL 1 beta on D10S cells revealed a novel 46 kD band on gradient SDS PAGE corresponding to a binding protein of 29 to 30 kD , which is antigenically distinct from the 80 kD IL 1R . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Finally , the fragment in position 163 171 appears to be responsible for a restricted series of the IL 1 beta activities , mainly directed to the immune system , although irrelevant for inflammation related effects and unable of binding to the IL 1R . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The expression of interleukin 1 receptors ( IL 1R ) on human peripheral T cells was studied by the binding assay with 125I labeled recombinant human interleukin 1 ( IL 1 ) alpha and IL 1 beta and by the flow cytofluorometry with the fluorescein isothiocyanate ( FITC ) conjugated IL 1 alpha . ^^^ These results suggest that IL 1R on human peripheral T cells reactive for IL 1 alpha and IL 1 beta were identical . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Recently , naturally occurring inhibitors of TNF alpha and IL 1 beta have been characterized such as soluble TNF receptors ( sTNFRs ) and IL 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Under basal conditions the expression of IL 1 alpha , IL 1 beta and IL 1ra mRNAs in the brain was extremely low for the three cytokines ; in the spleen these mRNAs were clearly detectable . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1 receptor antagonist ( IL 1ra ) in concentrations 50 and 200 fold higher than IL 1 beta completely blocked the IL 1 beta induced increase in SCBF when both compounds were administered concomitantly , but when administered alone , IL 1ra did not affect SCBF or other parameters . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Particulate beta glucan induced IL 1Ra production from human peripheral blood mononuclear cells ( PBMC ) but did not stimulate IL 1 beta synthesis or gene expression in these same cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Cytokine indices in Alzheimer ' s temporal cortex : no changes in mature IL 1 beta or IL 1RA but increases in the associated acute phase proteins IL 6 , alpha 2 macroglobulin and C reactive protein . ^^^ We investigated the levels of these proteins quantitatively using ELISA procedures and determined if increases in IL 1 beta were compensated for by a parallel increase in the endogenous interleukin 1 receptor antagonist ( IL 1RA ) . ^^^ Alzheimer ' s temporal cortex , we examined mature IL 1 beta , IL 1RA , IL 6 , alpha 2 M and C reactive protein ( CRP ) . ^^^ There were no differences in the levels of mature IL 1 beta or IL 1RA in AD and control brains . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Unlike IL 1 alpha and IL 1 beta , IL 1RA mRNA and protein were present at detectable levels in normal rabbit colon . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1R agonists , recombinant murine IL 1 alpha ( rmIL 1 alpha , 10 ng / ml ) and recombinant rat IL 1 beta ( rrIL 1 beta , 100 pg / ml or 10 ng / ml ) induce the upregulation of mRNA expression for both types of IL 1 receptors ( IL 1Rs ) . ^^^ Binding studies with 125I recombinant human IL 1 beta ( 125I rhIL 1 beta ) indicate that IL 1R gene products , with the ligand binding characteristics of the type 1 IL 1R , are constitutively present on Rinm5F cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Plasma levels of cytokines , tumor necrosis factor alpha ( TNF alpha ) , interleukin ( IL ) 6 , IL 8 , IL 1 beta , IL 1 receptor antagonist ( IL 1ra ) , granulocyte macrophage colony stimulating factor ( GM CSF ) , and VCAM 1 , were measured by enzyme linked immunosorbent assay . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In healthy subjects , sELAM 1 correlated with the serum levels of Il 1 beta , Il 1 receptor antagonist ( Il 1RA ) and Il 6 , while sGMP 140 was associated with Il 8 , and sVCAM 1 was related to Il 7 and Il 8 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
LPS could be mimicked by i . c . v . application of recombinant human IL 1 beta ( hIL 1 beta ; 100 ng ) . i . c . v . pretreatment with the IL 1 receptor antagonist ( IL 1ra ; 10 micrograms ) antagonized the hIL 1 beta induced effects . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The addition of pentoxifylline ( 10 ( 3 ) mol / L ) to monocytes during MCM preparation blocked TNF alpha production but not that of IL 1 beta or IL 6 , and it reduced IL 1ra significantly ( p < 0 . 05 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1 receptor antagonist IL 1ra was found in great molar excess in the secretions and correlated significantly with IL 8 , but not IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
An antagonist of the IL 1 receptor , IL 1ra , blocked the co mitogenic effect of IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 beta ( IL 1 beta ) and IL 1 receptor antagonist ( IL 1Ra ) synthesis was found to be induced by EBV . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
A blocking Ab against the type 1 IL 1R completely inhibited , in both normal and OA cells , the receptor binding and IL 1 beta stimulated PGE 2 production , whereas the treatment with anti type 2 IL 1R was ineffective . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In in vitro experiments in human peripheral blood mononuclear cells ( MNCs ) , IL 10 ( 0 . 25 4 . 0 ng ml 1 ) inhibited in a dose dependent manner PGE 2 production by MNCs stimulated with IL 1 beta ( 1 64 ng ml 1 ) or endotoxin ( lipopolysaccharide , LPS , 1 iu = 143 pg ml 1 ) but evoked only small increases in IL 1ra production . 7 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Allelic polymorphism in IL 1 beta and IL 1 receptor antagonist ( IL 1Ra ) genes in inflammatory bowel disease . ^^^ Since the final outcome of the biological effects of IL 1 beta may depend on the relative proportion of these two cytokines , we have studied if a TaqI polymorphism in the IL 1 beta gene , which is relevant to IL 1 beta protein production , may be involved in the genetic susceptibility to UC and Crohn ' s disease ( CD ) , in association with the established IL 1Ra gene polymorphism . ^^^ Polymorphisms in the closely linked genes for IL 1 beta and IL 1Ra were typed in 100 unrelated Dutch patients with UC , 79 with CD , and 71 healthy controls . ^^^ The polymorphic regions in exon 5 of the IL 1 beta gene and in intron 2 of the IL 1Ra gene , were studied by polymerase chain reaction ( PCR ) based methods . ^^^ In order to study if the IL 1 beta gene polymorphism might participate synergistically with the IL 1Ra gene polymorphism in susceptibility to UC and CD , individuals were distributed into carriers and non carriers of allele 2 of the genes encoding IL 1 beta and IL 1Ra , in each of the patient groups and controls . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The interleukin 1 ( IL 1 ) system is constituted by IL 1 alpha and IL 1 beta and IL 1 receptor antagonist ( IL 1ra ) that bind the same IL 1 receptors . ^^^ We have studied the effects of CRH ( 0 . 1 100 nM ) on IL 1 beta and IL 1ra expression by human peripheral monocytes in culture activated with different doses of lipopolysaccharide ( LPS ) . ^^^ In the absence of LPS , CRH up regulated IL 1ra and IL 1 beta messenger RNA expression as well as protein synthesis . ^^^ In contrast , in combination with high doses of LPS ( 1 microgram / ml ) , CRH caused inhibition of IL 1ra and IL 1 beta transcription and secretion . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Rat hypothalamic explants were incubated with mouse monoclonal antibodies ( mAbs ) raised against human IL 1 type 1 or type 2 receptors , IL 1 receptor antagonist ( IL 1ra ) and alpha melanocyte stimulating hormone ( alpha MSH ) ( which appears to antagonize certain IL 1 induced inflammatory effects in vivo ) , alone and in the presence of IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Mapping of receptor binding sites on IL 1 beta by reconstruction of IL 1ra like domains . ^^^ Upon structure comparison between IL 1 beta and its antagonist IL 1ra , single or multiple residues along the IL 1 beta sequence were replaced with the corresponding amino acids present in the IL 1ra protein , in the attempt to identify sites important for receptor binding and for biologic activity on the two molecules . ^^^ Agonist ( IL 1 beta ) and nonagonist ( IL 1ra ) binding to IL 1RI occur through distinct sites , with loops 164 173 and 202 214 of IL 1 beta identified as two of the sites selectively involved in agonist binding to the activating receptor . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 receptor antagonist protein ( IL 1ra ) competitively inhibited IL 1 beta stimulated NO synthesis , implying activation through a cell specific receptor . ^^^ Rats injected with both LPS and IL 1ra showed decreased hepatic iNOS mRNA and plasma NO 2 + NO 3 compared with rats given LPS alone , indicating that IL 1 beta plays a role in regulating iNOS expression within the liver in vivo during endotoxemia . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE To assess the value of measuring circulating concentrations of mediators ( endotoxin , tumor necrosis factor alpha [ TNF alpha ] , interleukin 1 beta [ IL 1 beta ] , and interleukin 6 [ IL 6 ] ) and their endogenous antagonists ( antiendotoxin core antibody [ EndoCAb ] , interleukin 1 receptor antagonist [ IL 1ra ] , and soluble TNF receptors [ sTNF R ] ) in predicting mortality and organ failure in sepsis syndrome . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
These priming and triggering effects of IL 1 alpha and IL 1 beta on the respiratory burst in human neutrophils were completely inhibited by IL 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 receptor antagonist ( IL 1ra ) is a naturally occurring antagonist of IL 1 beta . ^^^ Interestingly , the mean Il 1RA plasma concentration is a factor 50 100 higher than the IL 1 beta plasma concentrations . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Intraperitoneal ( i . p . ) administration of IL 1ra ( 8 mg / kg ) blocked the effect of i . p . injection of IL 1 beta ( 4 micrograms / rat ) on social behaviour but not on body weight . ^^^ Central administration of IL 1ra ( 60 micrograms / rat , i . c . v . ) abrogated the effects of centrally administered IL 1 beta ( 30 ng / rat , i . c . v . ) on both social behaviour and body weight . ^^^ Central injection of IL 1ra ( 4 micrograms / rat , i . c . v . ) also attenuated the effects of i . p . administered IL 1 beta ( 4 micrograms / rat ) on social behaviour but not on body weight . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present study , we investigated the production of cytokines IL 1ra , IL 1 beta , and IL 6 in patients undergoing a range of surgical procedures to examine whether IL 1ra release is a general phenomenon or is restricted to certain categories of surgery . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In HD patients , the molar ratios of plasma IL 1Ra : IL 1 beta range from 3 : 1 to 4 : 1 and the molar ratios of plasma sTNFR : TNF range from 13 : 1 to 38 : 1 . ^^^ In fact , endotoxin stimulated PBMC from all three groups of patients with renal failure produced significantly more IL 1Ra than IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We have previously shown that there is extensive cytokine production and secretion in the rectal mucosa in shigellosis ( interleukin 1 alpha [ IL 1 alpha ] , IL 1 beta , IL 1ra , IL 4 , IL 6 , IL 8 , IL 10 , tumor necrosis factor alpha [ TNF alpha ] , TNF beta , gamma interferon , granulocyte macrophage colony stimulating factor , and transforming growth factor beta [ TGF beta ] ) ( R . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Modulation of acute myeloblastic leukemia ( AML ) cell proliferation and blast colony formation by antisense oligomer for IL 1 beta converting enzyme ( ICE ) and IL 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Moreover , fibroblast conditioned supernatants containing IL 1Ra significantly suppress the mitogenic response of a T cell clone , D10G4 . 1 , to concanavalin A and IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Neutralizing Abs to IL 1 beta and IL 10 had no effect , while simultaneous treatment with anti TNF alpha , anti granulocyte macrophage CSF , and anti TGF beta nearly abrogated IL 1Ra release , supporting an indirect induction through the concerted action of the co produced cytokines . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Our further study showed that intracerebroventricular ( icv ) injection of interleukin 1 receptor antagonist ( IL 1Ra ) antagonised the generation of serum suppressive factor induced by restraint stress and icv injection of interleukin 1 beta ( IL 1 beta ) increased the generation of the suppressive factor . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We have assessed the levels of interleukin 1b ( IL 1b ) and interleukin 1 receptor antagonist ( IL 1RA ) in both serum and peritoneal dialysate effluents ( PDE ) from nineteen continuous ambulatory peritoneal dialysis patients ( CAPD ) without peritonitis and three CAPD patients with peritonitis . ^^^ IL 1 beta and IL 1RA were tested using a specific ELISA immuno assay . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Since IL 1sR can also bind IL 1Ra , we studied the simultaneous effects of both inhibitors on the production of interstitial collagenase ( C ' ase ) and PGE 2 by human dermal fibroblasts and synovial cells stimulated by either IL 1 alpha or IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
However , the insertion of the beta bulge ( QGEESN ) of IL 1 beta at the corresponding region of IL 1ra K145D resulted in a 3 4 fold augmentation of bioactivity . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The results from Cl2MBP liposome treated mice also suggested that splenic macrophages were the primary producers of LPS induced IL 1 beta , IL 6 , IL 12 ( p 40 ) , and IL 1 receptor antagonist ( IL 1ra ) mRNA , but not IL 10 and TNF alpha mRNA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In contrast , the binding affinity to the type 2 IL 1R ( IL 1RII ) is the same as that of wild type IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Five of the residues in the IL 1 alpha binding site align with the binding residues previously determined in human IL 1 beta , demonstrating that the type 1 IL 1R recognizes homologous regions in both ligands . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Specifically , there are no reports to date characterizing IL 1R 2 detection by enzyme linked immunoassay in the presence of IL 1 beta or characterizing IL 1 beta detection in the presence of IL 1R 2 . ^^^ This study addresses the detection and quantitation of IL 1R 2 and IL 1 beta by a number of sandwich ELISA formats and characterizes the sensitivity of detection in the presence of competitive cytokines . ^^^ In this context , a 4 : 1 molar ratio of IL 1 beta to IL 1R 2 interferes with the IL 1R 2 detection by the M22 / R2 but not the M2 / R2 ELISA . ^^^ Conversely , IL 1R 2 at physiologically relevant concentrations interferes with the detection of IL 1 beta by three distinct IL 1 beta ELISA formats . ^^^ Taken together , these studies suggest that when measuring samples that may contain both IL 1 beta and IL 1R 2 , careful attention must be given to assay specificity . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
This open label study examines whether methotrexate ( MTX ) treatment modulates ex vivo synthesis of interleukin 1 receptor antagonist ( IL 1ra ) , soluble tumour necrosis factor receptors ( sTNFR p 55 and p 75 ) , interleukin 1 beta ( IL 1 beta ) , tumour necrosis factor alpha ( TNF alpha ) , interleukin 8 ( IL 8 ) and monocyte chemoattractant protein 1 ( MCP 1 ) by peripheral blood mononuclear cells ( PBMC ) and whether changes reflect clinical response . ^^^ When defining the characteristics of patients at study entry retrospectively in responders and non responders , a significantly lower ratio of IL 1ra : IL 1 beta production before and its increase upon treatment was associated with clinical response in 13 patients compared to five patients not responding to MTX . ^^^ Pretreatment determination of the IL 1ra : IL 1 beta ratio in PBMC may be predictive with regard to a favourable therapeutic response and therefore may be useful for the selection of RA patients to be treated with MTX . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
After 24 hour incubation , total cell associated IL 1Ra and IL 1 beta were measured by specific radioimmunoassay . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Neither IL 1 beta nor IL 1ra mRNA was present in monocytes just after the isolation , but they were induced simultaneously in response to various stimulants . ^^^ In contrast , only IL 1 beta mRNA was expressed in monocytic leukemia cell line JOSK 1 , while little or no IL 1ra mRNA was detected even after stimulation . ^^^ Dominant expression of IL 1 beta over IL 1ra was also observed in fresh leukemia cells including monocytic leukemias , i . e . , IL 1 beta mRNA was constitutively expressed in 26 out of 36 cases ( 72 . 2 % ) , whereas IL 1ra mRNA was present only in 8 cases ( 22 . 2 % ) . ^^^ The signal intensity of IL 1 beta mRNA was stronger than that of IL 1ra even in IL 1ra positive cases . ^^^ Apoptotic cell death of monocytes was significantly inhibited by IL 1 beta , and it was enhanced by IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
This study was undertaken to determine whether acute phase proteins ( APP ) induce the synthesis of interleukin 1 beta ( IL 1 beta ) and its specific antagonist , IL 1 receptor antagonist ( IL 1Ra ) , in human peripheral blood mononuclear cells ( PBMC ) . ^^^ PBMC from healthy volunteers were incubated with C reactive protein ( CRP ) , alpha 1 antitrypsin ( alpha 1 AT ) , or alpha 1 acid glycoprotein ( AGP ) , and the levels of IL 1 beta and IL 1Ra produced were measured by specific radioimmunoassay . ^^^ PBMC incubated for 24 h with CRP , alpha 1 AT , or the pentapeptide FVYLI synthesized large quantities of IL 1Ra , 5 10 fold greater than the amount of IL 1 beta produced by these cells . ^^^ CRP , alpha 1 AT , FVYLI , and AGP were synergistic with low concentrations of endotoxin in the induction of both IL 1Ra and IL 1 beta synthesis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We have shown that AIDS KS spindle cells express IL 1 beta and that IL 1ra inhibits KS spindle cell growth . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Administration of IL 1Ra also diminished the increases in IL 1 beta and IL 6 mRNA levels that occur in the lungs following hemorrhage . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1ra / IL 1 beta tissue concentration ratio in the affected areas was decreased in patients with active IBD as compared with normal controls or patients with other types of colitis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Since the conditioned culture media from the HITra 2 cells exhibited an anti IL 1 beta activity of only 0 . 5 U / ml , and mixed culture of HITra 2 cells and isolated rat islets prevented IL 1 beta induced inhibition of insulin release , it is likely that IL 1ra acts locally at the cell surface . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In U 937 H cells that strongly express high levels of CD 26 , DP 4 inhibitors were shown to suppress DNA synthesis and production of IL 1 beta , but stimulate the secretion of the IL 1 receptor antagonist ( IL 1RA ) and of TNF alpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The determinations of IL 1 alpha , IL 1 beta , TNF alpha , IL 6 , and IL 1ra in culture medium were carried out using specific ELISA . ^^^ Conversely , IL 1 beta production was not inhibited by IL 1ra , irrespective of the concentration used and whether the membranes were LPS stimulated . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Injection of rabbit IL 8 induced bioactive and immunoreactive IL 1 beta and IL 1 receptor antagonist ( IL 1Ra ) in the joint cavity . ^^^ Immunohistochemistry showed that IL 1 beta and IL 1Ra positive cells were infiltrating leukocytes . ^^^ In neutrophil depleted rabbits , rabbit IL 8 induced far lesser concentrations of IL 1 beta and IL 1Ra and no cartilage destruction compared with findings in normal rabbits . ^^^ In addition to neutrophil chemotactic activity , IL 8 proved to have a neutrophil activating capability in vivo , with respect to release of neutrophil elastase and induction of IL 1 beta and IL 1Ra . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In cells exposed to IL 1 beta , it also moderately stimulated IL 1ra production and release of soluble tumor necrosis factor receptor p 75 ( sTNF R p 75 ) and inhibited IL 8 and MCP 1 production . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Identification of a single site in IL 1ra and two sites in IL 1 beta . ^^^ Extensive site directed mutagenesis has been used to identify residues in IL 1ra and IL 1 beta involved in binding to IL 1RI . ^^^ Interestingly , the absent second site is at the location of the major structural difference between IL 1ra and IL 1 beta , which are otherwise structurally similar . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Patients with rheumatoid arthritis ( RA ) have defective hypothalamic responses to inflammation , possibly because of excessive production of cytokine inhibitor , which could blunt the effects of cytokines on the hypothalamus , or because of an imbalance between interleukin 1 beta ( IL 1 beta ) and interleukin 1 receptor antagonist ( IL 1Ra ) , which could create a mainly proinflammatory state . ^^^ The in vivo kinetics of IL 1 beta and IL 1Ra secretion were studied in patients with RA , osteoarthritis ( OA ) , and chronic osteomyelitis ( OM ) , and in normal controls before and after surgery . ^^^ RA patients had an IL 1Ra : IL 1 beta ratio of 26 . 2 + / 3 . 7 ( mean + / SEM ) at baseline ( OM patients 89 . 2 + / 5 . 8 and OA patients 1 , 310 + / 363 ) ; this increased to 66 . 5 + / 19 . 8 after surgery ( OM patients 120 + / 6 . 7 and OA patients 325 . 8 + / 106 ) . ^^^ RA patients have a dysregulation of IL 1Ra production , and it seems unlikely that the defective hypothalamic response seen in RA is due to a functional deficit of IL 1 beta . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 receptor antagonist ( IL 1ra ) is a member of the IL 1 family , which bind to IL 1 receptors and blocks the action of IL 1 alpha and IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Identification of IL 1 inhibitory activity as IL 1 receptor antagonist ( IL 1ra ) in vitro and kinetics of IL 1ra and IL 1 beta in experimental rabbit lung granuloma . ^^^ This study investigated whether interleukin 1 ( IL 1 ) inhibitory activity in LPS stimulated culture supernatants of alveolar macrophages and epithelioid cells obtained from rabbit lung granulomas induced by complete Freund ' s adjuvant ( CFA ) was identical to IL 1 receptor antagonist ( IL 1ra ) and examined the changes of IL 1ra and IL 1 beta levels in lung tissue during the natural course of granulomatous inflammation . ^^^ Pulmonary tissue levels of IL 1 beta pecked at 24 h ( 52 . 0 + / 9 . 5 pg / mg ) after CFA injection , whereas IL 1ra levels peaked at 4 weeks ( 23 . 1 + / 4 . 0 ng / mg ) when granuloma development was maximal , and the molar excess of IL 1ra to IL 1 beta peaked from 4 weeks onward at over 800 fold . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The addition of IVIg to cultures of purified monocytes induced a dose dependent secretion of IL 1ra and IL 8 without stimulating the production of IL 1 alpha , IL 1 beta , tumor necrosis factor alpha or IL 6 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In mammalian cells expressing natural or recombinant Type 1 IL 1R and IL 1R AcP , the accessory protein forms a complex with the Type 1 IL 1R and either IL 1 alpha or IL 1 beta but not IL 1ra . ^^^ The recombinant accessory protein also increases the binding affinity of the recombinant Type 1 IL 1R for IL 1 beta when the two receptor proteins are coexpressed . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Because this response is considered to be mediated by cytokines , we measured the acute phase proteins C reactive protein ( CRP ) and soluble type 2 phospholipase A 2 ( PLA 2 ) together with circulating concentrations and ex vivo production of the proinflammatory cytokines interleukin 1 alpha ( IL 1 alpha ) , IL 1 beta , IL 6 , and tumor necrosis factor alpha ( TNF alpha ) and the inhibitory compounds IL 1 receptor antagonist ( IL 1ra ) , IL 10 , and the soluble TNF receptors p 55 ( sTNFr p 55 ) and p 75 ( sTNFr p 75 ) in 22 patients with the hyper IgD syndrome during attacks and remission . ^^^ The ex vivo production of TNF alpha , IL 1 beta , and IL 1ra was significantly higher with attacks , suggesting that the monocytes / macrophages were already primed in vivo to produce increased amounts of these cytokines . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Using the in situ hybridization of biotin labeled probe and streptavidin alkaline phosphatase conjugate detection system , we quantitatively analysed by true colour medical image analysis system the expression of IL 1 beta , IL 1ra mRNA of peripheral blood mononuclear cells ( PBMC ) from 4 cases of idiopathic nephrotic syndrome . ^^^ IL 1 beta IL 1ra mRNA expression of PBMC in INS were significantly lower than those of the normal control ( 107 . 63 + / 20 . 80 vs 195 . 56 + / 31 . 14 ; 144 . 45 + / 11 . 42 vs 370 . 38 + / 100 . 48 , respectively , P < 0 . 05 ) . ^^^ The expression of IL 1 beta mRNA was significantly lower than the IL 1ra mRNA expression of PBMC in INS ( 107 . 63 + / 20 . 80 vs 144 . 45 + / 11 . 42 , P < 0 . 05 ) . ^^^ There existed dysregulation of IL 1 beta , IL 1ra mRNA expression in INS . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The plasma levels of endotoxin , TNF alpha , IL 1 beta , and PAI 1 decreased toward normal levels within the first 24 h of treatment , but IL 6 and IL 1ra levels remained high until clinical recovery . ^^^ On admission , the molar excess of IL 1ra to IL 1 beta was > 2000 fold in 11 of the 13 patients . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Acute disruption of the permeability barrier by either tape stripping or acetone treatment and chronic disruption by feeding an essential fatty acid deficient diet increase the mRNA levels of tumor necrosis factor alpha ( TNF alpha ) , interleukin ( IL ) 1 alpha , IL 1 beta , IL 1ra , and granulocyte / macrophage colony stimulating factor in murine epidermis . ^^^ Latex occlusion of essential fatty acid deficient mice for 24 48 h lowered the mRNA levels of epidermal TNF alpha , IL 1 alpha , and IL 1ra to nearly control values , but not the levels of IL 1 beta mRNA . ^^^ Occlusion of normal mice for 8 , 24 , and 48 h did not alter the levels of epidermal mRNAs encoding TNF alpha , IL 1 beta , or IL 1ra . ^^^ In contrast , latex occlusion of mice immediately after acute barrier disruption by either tape stripping or acetone treatment blocked neither the stimulation of epidermal mRNAs for TNF alpha , IL 1 alpha , IL 1 beta , or IL 1ra , nor the increase in epidermal TNF alpha protein . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
However , the concomitant addition of increasing concentrations of IL 1ra ( 10 to 5 , 000 ng / mL ) yielded dose dependent reversal of the 10 ng / mL IL 1 beta mediated inhibition of the FSH supported accumulation of P . ^^^ Similarly , the ability of IL 1 beta to exert a dose dependent ( 0 to 30 ng / mL ) anti gonadotropic effect was attenuated progressively given the concurrent presence of increasing concentrations ( 1 , 000 and 5 , 000 ng / mL ) of IL 1ra . ^^^ Although treatment of whole ovarian dispersates with 10 ng / mL IL 1 beta resulted in a 5 . 4 fold increase in the accumulation of prostaglandin ( PG ) E 2 , this effect too was all but eliminated after the concomitant addition of 5 micrograms / mL IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Using site directed mutagenesis , we have determined the location and composition of the binding sites in human IL 1 alpha and IL 1 beta for the Type 1 IL 1 receptor ( IL 1R ) . ^^^ Although human IL 1 alpha and IL 1 beta have similar affinities and cross compete for binding to the human Type 1 IL 1R , the binding site residues are not identical in the two ligands . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
This study determined the potential capacity of interleukin 10 ( IL 10 ) , compared with IL 4 , to control the production of tumour necrosis factor alpha ( TNF alpha ) , IL 1 beta and IL 1 receptor antagonist ( IL 1ra ) and the expression of major histocompatibility complex ( MHC ) class 2 antigens by monocytes / macrophages isolated from synovial fluid of patients with rheumatoid or other forms of chronic inflammatory arthritis . ^^^ TNF alpha , IL 1 beta and IL 1ra levels were measured by enzyme linked immunosorbent assay ( ELISA ) in the culture supernatants , and MHC class 2 expression was examined on the monocytes / macrophages by flow cytometry . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We determined circulating levels of IL 1 beta and IL 1Ra , TNF alpha and its soluble receptors ( TNF sR 55 and TNF sR 75 ) , and activation markers of T cells ( soluble CD 25 ) , B cells ( soluble CD 23 ) , and monocytes ( neopterin ) in a large cohort of undialyzed patients at various stages of chronic renal failure and in dialyzed patients on maintenance hemodialysis or chronic peritoneal dialysis . ^^^ Although IL 1 beta could not be detected , IL 1Ra levels were significantly increased from the earliest stage of renal failure . ^^^ Compared with undialyzed patients , levels of IL 1 beta were higher in patients on maintenance hemodialysis , whereas those of IL 1Ra were lower and decreased further at the end of dialysis sessions . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The binding of IL 1 beta to its receptor can be blocked by high concentrations of interleukin 1 receptor antagonist ( IL 1Ra ) , which is produced and released upon nearly the same stimuli as IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : The in vitro secretion of proinflammatory cytokines ( IL 1 beta , tumor necrosis factor alpha [ TNF alpha ] , and IL 1 receptor antagonist [ IL 1ra ] ) by peripheral monocytes and by intestinal lamina propria mononuclear cells ( LPMNCs ) was assessed by enzyme linked immunosorbent assay . ^^^ RESULTS : IBD peripheral monocytes and intestinal LPMNCs in vitro secrete increased amounts of proinflammatory cytokines ( IL 1 beta and TNF alpha ) with decreased IL 1ra / IL 1 beta ratios . ^^^ The IL 1ra / IL 1 beta ratios in normal monocytes are increased by IL 4 , whereas in IBD monocytes low IL 1ra / IL 1 beta ratios persist after IL 4 treatment . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Patients had significantly higher ( P < 0 . 005 ) numbers of cytokine producing cells for all of the cytokines studied , interleukin 1 alpha ( IL 1 alpha ) , IL 1 beta , IL 1ra , tumor necrosis factor alpha ( TNF alpha ) , IL 6 , IL 8 , IL 4 , IL 10 , gamma interferon , TNF beta , and transforming growth factor beta 1 3 , in the biopsies than the healthy controls ( n = 13 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Differences were identified with IL 1 beta ( control = 162 + / 57 vs . perforating = 464 + / 154 vs . nonperforating = 12 , 582 + / 4733 ; P < or = 0 . 02 ) and IL 1ra ( control = 1337 + / 622 vs . perforating = 2194 + / 775 vs . nonperforating = 9715 + / 2988 ; P < or = 0 . 02 ) . ^^^ Nonperforating CD , the more benign form , is associated with increased IL 1 beta and IL 1ra mRNA expression . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The production of IL 1ra and proinflammatory cytokines , such as IL 1 beta , IL 6 , and tumor necrosis factor alpha ( TNF alpha ) , were quantitated by enzyme immunoassays . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The spontaneous production of IL 1 beta ( IL 1 beta ) and IL 1 receptor antagonist ( IL 1Ra ) by rheumatoid arthritis ( RA ) synovium , and the regulation of their production by IL 4 and IL 10 , were studied . ^^^ Supernatants from cultured synovium pieces from 19 RA patients were assayed for IL 1 beta and IL 1Ra production using ELISA and RIA , respectively . ^^^ After 10 days of culture , spontaneous production of IL 1Ra was 1 . 42 + / 0 . 43 ng / ml / 100 mg of synovium whereas spontaneous production of IL 1 beta was 4 . 03 + / 0 . 90 ng / ml / 100 mg of synovium ( n = 19 ) . ^^^ The addition of IL 4 reduced IL 1 beta production by 2 . 3 fold ( p = 0 . 001 ) and increased that of IL 1Ra by 2 . 8 fold ( p = 0 . 003 ) . ^^^ IL 10 had no significant effect on IL 1Ra production and suppressed IL 1 beta production ( primarily in samples producing high levels of IL 1 beta ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The transport system for IL 1ra appeared to be linked to that for IL 1 alpha and IL 1 beta , but was not affected by IL 2 , IL 6 , TNF alpha , or MIP 1 alpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Mini osmotic pumps releasing human recombinant IL 1 receptor antagonist ( IL 1ra ) protein were implanted intraperitoneally 2 days before arthritis induction , and neutralizing antibodies directed against murine IL 1 alpha , IL 1 beta , TNF alpha , or IL 6 were administered 1 day before . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Collectively , additional factor ( s ) besides IL 1Ra and IL 1 beta may control IL 6 and some other cachexigenic factor production , thereby causing cachexia in this model . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We wished to determine the sets of conditions ( cytokine combinations ) that would enable us to demonstrate stable inter individual differences in the production of IL 1 alpha , IL 1 beta , IL 1Ra , on 6 and tumour necrosis factor alpha ( TNF alpha ) by monocytes . ^^^ TNF alpha also up regulated production of IL 1 alpha , IL 1 beta , IL 1Ra and IL 6 by monocytes , but the variability in the results of cells cultured from the same individuals on different occasions was greater . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We obtained affinity purified polyclonal anti id antibodies against mAb MhC 1 and BrhC 3 , which recognize amino acids 133 147 at the N terminus of mature human IL 1 beta . mAb MhC 1 and BrhC 3 have been shown to inhibit binding of IL 1 beta to type 1 IL 1R , and to neutralize IL 1 beta bioactivity in a number of in vitro assays . ^^^ We show that affinity purified antibodies against the MhC 1 and BrhC 3 idiotypes specifically bind to type 1 IL 1 beta IL 1R and that this binding is inhibited by both IL 1 beta and IL 1ra ; anti id antibodies were also able to trigger IL 1R dependent events , such as IL 8 secretion by human skin fibroblasts and pyrogenic effect after injection in mice . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 beta induced adhesion was inhibited by preincubation of the cells with an IL 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Three naturally occurring IL 1 molecules are known , two agonists : IL 1 alpha and IL 1 beta , and one antagonist , the IL 1 receptor antagonist ( IL 1ra ) . ^^^ The crystal structure of IL 1ra has been solved at 0 . 21 nm resolution by molecular replacement using the IL 1 beta structure as a search model . ^^^ IL 1ra has the same fold as IL 1 alpha and IL 1 beta . ^^^ Comparison of the IL 1ra structure with the IL 1 alpha and IL 1 beta structures present in the Protein Data Bank shows that a putative receptor interaction region , involving the N terminus up to the beginning of strand beta 1 and the loops D and G , is very different in the three IL 1 molecules . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Type 2 sIL 1R and IL 1ra had an additive effect in inhibiting the binding of IL 1 beta to cell surface IL 1 receptors . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Increased IL 1 receptor antagonist ( IL 1ra ) production and decreased IL 1 beta / IL 1ra ratio in mononuclear cells from rheumatoid arthritis patients . ^^^ In order to investigate the possible role of IL 1 receptor antagonist ( IL 1ra ) in patients with rheumatoid arthritis ( RA ) , this study was undertaken to measure the amounts of IL 1ra and interleukin 1 beta ( IL 1 beta ) protein produced by mononuclear cells ( MNC ) and to investigate the relationship between production of these cytokines and clinical parameters . ^^^ The MNC were cultured for 24 h and the supernatants were measured for IL 1ra and IL 1 beta by ELISA kits . ^^^ When the IL 1 beta / IL 1ra ratio was calculated , IL 1 beta / IL 1ra ratios of RA PBMNC were significantly lower than those of normal PBMNC ( P < 0 . 001 ) . ^^^ The IL 1 beta / IL 1ra ratio of RA PBMNC was significantly higher in active RA patients than in RA patients in remission ( P < 0 . 02 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
An in vivo cross over study has investigated plasma and cellular levels of IL 1 ( IL 1 alpha IL 1 beta and IL 1Ra ) when using Cuprophan ( C ) and cellulose triacetate ( CTA ) membranes to assess the roles of complement activation and dialysate endotoxin content in the induction of cytokines during the dialysis procedure . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Type 1 : TGF alpha , IL 1 beta , and PDGF B were expressed exclusively by epithelial cells but their respective receptors EGFR and IL 1R were predominantly and PDGFR beta was exclusively expressed by fibroblasts . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Treatment with IL 1ra did not affect the steady state mRNA expression of either IL 1 beta or TNF alpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Co addition of the specific IL 1 receptor antagonist ( IL 1ra ) completely inhibited IL 1 beta induced IL 6 secretion but did not affect LPS stimulated IL 6 production during a 6 h incubation period . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Although only a modest but statistically significant increase in plasma levels of IL 1 beta was seen , IVIG infusion was followed by a marked increase in plasma levels of IL 1Ra with 1 , 000 fold molar excess of IL 1Ra to IL 1 beta in some patients . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Resting ovine ALDC express approximately 510 IL 1R per cell for IL 1 alpha ( Kd approximately 30 pM ) and approximately 350 IL 1R / cell for IL 1 beta ( Kd approximately 160 pM ) . ^^^ Fresh ovine alveolar macrophages , used as a positive control for specific IL 1R expression , were found to express approximately 2600 sites / cell for IL 1 alpha ( Kd approximately 56 pM ) and 16 , 500 sites / cell for IL 1 beta ( Kd approximately 4 . 6 pM ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the regulation of messenger ribonucleic acid ( mRNA ) levels of interleukin 1 beta ( IL 1 beta ) , interleukin 1 ( IL 1 ) receptor type 1 , and plasminogen activator ( PA ) inhibitor 1 and 2 in cumulus cells , granulosa luteal cells , and macrophage depleted granulosa luteal cells obtained from human preovulatory follicles . ^^^ MAIN OUTCOME MEASURES : Northern blot analysis of mRNA levels of IL 1 beta , IL 1 receptor type 1 , PA inhibitor 1 and 2 in cumulus cells , granulosa luteal cells and macrophage depleted granulosa luteal cells , and indirect immunocytochemical analysis of the IL 1 system and macrophages in granulosa luteal cell preparations were performed . ^^^ Granulosa luteal cell IL 1 receptor type 1 mRNA levels were expressed constitutively throughout 24 hours of culture with no effect by hCG , whereas IL 1 beta mRNA levels increased within 6 hours , and then remained elevated for 24 hours with no effect by hCG . ^^^ Interleukin 1 beta significantly increased granulosa luteal cell mRNA levels of IL 1 beta ( over twofold ) , IL 1 receptor type 1 ( over twofold ) , PA inhibitor 1 ( approximately 1 . 4 fold ) , and PA inhibitor 2 ( approximately 1 . 6 fold ) . ^^^ In contrast , IL 1 beta had no effect on IL 1 beta and IL 1 receptor type 1 mRNA levels in macrophage depleted granulosa luteal cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1ra is a competitive inhibitor of IL 1 alpha and IL 1 beta , and therefore is a powerful endogenous anti inflammatory molecule . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In this study , human recombinant IL 1ra , at 100 fold excess , was found to block bone resorption in cultured mouse calvaria due to IL 1 beta but not IL 1 alpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Circulating proinflammatory cytokines ( IL 1 beta , TNF alpha , and IL 6 ) and IL 1 receptor antagonist ( IL 1Ra ) in fulminant hepatic failure and acute hepatitis . ^^^ Serum concentrations of IL 1 beta , tumour necrosis factor alpha ( TNF alpha ) , IL 6 and IL 1 receptor antagonist ( IL 1Ra ) were measured in 30 patients with FHF and in 23 patients with acute hepatitis ( AH ) before start of treatment and in 23 healthy controls . ^^^ High serum levels of IL 1 beta and a significantly reduced ratio of IL 1Ra to IL 1 beta ( IL 1Ra / IL 1 beta ) were observed in FHF patients who subsequently died compared with subjects who survived . ^^^ The high cytokine levels observed in these patients and the significantly elevated IL 1Ra / IL 1 beta ratio in FHF patients who survived compared with those who did not suggest the possible therapeutic use of cytokine antagonists for the control of this life threatening disease . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
MCT treatment was also associated with an increase in lung mRNA for IL 1 alpha , IL 1 beta , and IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Activation of human monocytes or monocytic cell lines with all known stimuli coordinately induces the gene expression of various cytokines , including tumor necrosis factor alpha ( TNF alpha ) , interleukin 1 beta ( IL 1 beta ) , and the IL 1 receptor antagonist ( IL 1Ra ) . ^^^ In contrast , superantigens induce TNF alpha and IL 1 beta but fail to affect IL 1Ra gene expression , suggesting that activation of monocytes via major histocompatibility complex class 2 is distinct from other signal transduction pathways . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Reverse transcription polymerase chain reaction analysis was used to determine tumor necrosis factor alpha ( TNF alpha ) , interleukin 1 beta ( IL 1 beta ) , IL 6 , IL 10 , interferon gamma ( IFN gamma ) , monocyte chemotactic protein 1 ( MCP 1 ) , macrophage inflammatory protein 2 ( MIP 2 ) , and IL 1 receptor antagonist ( IL 1RA ) mRNA expression . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Specific mRNA was detected using cDNA probes encoding the proto oncogenes c fos and c myc and the growth arrest and DNA damage ( GADD 153 ) gene , all recently shown by our laboratory to be modulated by UV in newborn keratinocytes ; interleukin ( IL ) 1a , IL 1b , and the IL 1 receptor antagonist ( IL 1ra ) , two keratinocyte cytokines and their competitive inhibitor , implicated in the immunomodulatory effect of UV ; and SPR 2 , a recently cloned gene known to be induced during normal keratinocyte differentiation and by lethal UV C irradiation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To examine the relationship between the production of IL 1Ra and IL 1 , we incubated peripheral blood mononuclear cells ( PBMC ) with endotoxin ( 10 ng / ml ) and after 24 h measured the total synthesis ( intra and extracellular ) of IL 1Ra , IL 1 alpha and IL 1 beta . ^^^ The total synthesis of IL 1Ra closely correlated with that of IL 1 beta ( R = 0 . 786 , p < 0 . 001 ) . ^^^ These results suggest that in dialysis patients , the endogenous production of IL 1Ra is a ' footprint ' of IL 1 beta production and can probably be used as a marker of the level of production of IL 1 . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
PROBLEM : This study was conducted to determine whether ( 1 ) conditioned media from unstimulated primary cultures of human amnion , chorion , or decidua contain detectable concentrations of IL 1ra in vitro , and ( 2 ) bacterial endotoxin ( LPS ) , tumor necrosis factor alpha ( TNF alpha ) , or IL 1 beta ( IL 1 beta ) stimulate amnion , chorion , or decidua to produce increased amounts of IL 1ra . ^^^ In addition , LPS ( 10 1 , 000 ng / ml ) and IL 1 beta ( 0 . 1 10 ng / ml ) , but not TNF alpha ( 0 . 01 100 ng / ml ) , stimulated decidual cells to release / secrete increased amounts of IL 1ra compared with media alone ( range : 2 . 5 400 pg IL 1ra / microgram protein / 16 h , P < 0 . 0001 ) . ^^^ In contrast , neither LPS , TNF alpha , or IL 1 beta could stimulate amnion or chorion to release / secrete IL 1ra . ^^^ CONCLUSIONS : These results indicate ( 1 ) that amnion , chorion , and predominantly decidua , can release or secrete IL 1ra in vitro , and ( 2 ) that LPS and IL 1 beta can stimulate decidual cells to produce increased amounts of IL 1ra . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 alpha ( IL 1 alpha ) , interleukin 1 beta ( IL 1 beta ) , and interleukin 6 ( IL 6 ) are cytokines with potent bone resorbing effects ; some of these biologic effects are opposed by interleukin 1 receptor antagonist ( IL 1ra ) . ^^^ Serum IL 1 alpha , IL 1 beta , or IL 1ra level did not change with age and , by multiple regression analysis , did not correlate with markers of bone turnover , except IL 1ra weakly with ICTP . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To further assess the clinical implications of increased IL 1 beta expression in CML , we analyzed IL 1 beta and IL 1 receptor antagonist ( IL 1RA ) levels in leukocyte lysates from a series of CML patients and from normal volunteers . ^^^ Both IL 1 beta and IL 1RA were measured by enzyme linked immunosorbent assays ( ELISAs ) , with the lower limits of sensitivity of the assays being 20 pg / mL and 6 . 5 pg / mL , respectively . ^^^ Finally , although IL 1 beta has been previously shown to increase IL 1RA levels , there was no correlation between IL 1 beta and IL 1RA levels in our CML patients . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The biological activity of tumor necrosis factor ( TNF alpha / beta ) and interleukin 1 beta ( IL 1 beta ) can be blocked by soluble , naturally occurring molecules TNF alpha / beta binding proteins ( BP 55 and BP 75 ) , derived from the extracellular portion of the 55 and 75 kDa TNF alpha / beta membrane receptors , and IL 1 receptor antagonist ( IL 1ra ) , respectively . ^^^ Kinetic studies showed that both tumor cells and macrophages produced an initial burst of TNF alpha and IL 1 beta which was overtaken within 48 hr by a sustained production of TNF BP and IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We investigated the effect of treating B cell enriched , or , B plus T cell suspensions derived from either pre disease or diseased lupus prone MRL / lpr mice with IL 1 beta or IL 1 receptor antagonist ( IL 1Ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 beta bound more avidly to sIL 1RII than IL 1 alpha or IL 1ra , primarily because of a slow dissociation rate . ^^^ In contrast , IL 1 ra bound more avidly than IL 1 alpha or IL 1 beta to sIL 1RI , again because of a slow dissociation rate . sIL 1RII and sIL 1RI inhibited the detection of IL 1 beta and IL 1ra , respectively , by ELISA . ^^^ These results suggest that some IL 1 beta and IL 1ra may be bound in vivo to sIL 1RII and sIL 1RI , respectively , leading to underestimations of cytokine concentrations in body fluids when measured by ELISA . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 beta did not increase the mean plaque area in the presence of the IL 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Levels of C reactive protein ( CRP ) , interleukin 1 beta ( IL 1 beta ) , tumor necrosis factor alpha ( TNF alpha ) , IL 6 , IL 1 receptor antagonist ( IL 1ra ) , TNF soluble receptor 55 kd ( sTNFR 55 kd ) , and sTNFR 75 kd were tested in the serum of 15 patients with PM / DM , 14 patients with spondylarthropathies ( SPA ) , and 12 healthy blood donors . ^^^ Serum IL 1 beta , TNF alpha , IL 6 , IL 1ra , sTNFR were measured by specific immunoassays . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Blockade of membrane IL 1 alpha required a 30 fold and fivefold excess of IL 1Ra compared with the amount required to block soluble IL 1 beta and IL 1 alpha , respectively . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The purified , soluble IL 1R retained quantitatively the ability to bind to its ligand , IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
MEASUREMENTS AND MAIN RESULTS : Median plasma IL 1Ra , but not IL 1 beta or tumor necrosis factor alpha ( TNF alpha ) concentrations were markedly increased on the day of admission in patients with thermal injuries compared with controls ( 1615 [ range 426 to 23 , 800 ] vs . 494 [ range 196 to 1093 ] pg / mL ; p < . 001 ) . ^^^ In nonsurvivors , median IL 1Ra was 3 . 6 fold higher than IL 1 beta on days 1 to 2 and 36 fold higher than IL 1 beta in three patients with bacteremia . ^^^ However , IL 1Ra did not correlate with rectal temperature , plasma concentrations of endotoxin , IL 1 beta , or TNF alpha either at admission or in follow up samples . ^^^ With the current plasma assays for IL 1 beta , IL 1Ra may be a more sensitive marker of human inflammation than IL 1 beta or TNF alpha . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Activation of human monocytes or human monocytic cell lines by several types of stimuli coordinately induces IL 1 beta and its antagonist ( IL 1Ra ) gene expression ; alterations in their balance seem to mediate the inflammatory response . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
SF neutrophils produced significantly more IL 8 and IL 1 beta , but significantly less IL 1ra , than peripheral blood neutrophils . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Both forms of IL 1 , IL 1 alpha and IL 1 beta , induced this kinase activity , whereas the IL 1 receptor antagonist ( IL 1ra ) was inactive . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The purpose of this study was to examine the kinetics of local expression of IL 1ra gene in relation to IL 1 beta gene in a model of anti glomerular basement membrane antibody mediated glomerulonephritis . ^^^ Messenger RNA for IL 1ra and IL 1 beta was undetectable by Northern blot in normal glomeruli but increased markedly 4 to 6 hours after induction of nephritis . ^^^ The increase in IL 1ra mRNA was more sustained than that of IL 1 beta mRNA . ^^^ In situ hybridization showed that IL 1 beta mRNA increased diffusely within glomeruli , while IL 1ra mRNA was expressed more discretely . ^^^ Expression of these mRNA in noninflamed tissues , spleens and lungs , was different , particularly increase in IL 1ra mRNA was more substantial than that of IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Of the three forms of IL 1 , soluble type 2 IL 1R binds IL 1 beta with highest affinity and also selectively inhibits IL 1 beta activity . ^^^ We propose that increased cell surface expression and rapid release of preformed type 2 IL 1R from neutrophils , as a soluble IL 1 beta binding protein , represents a mechanism that has evolved for regulating IL 1 activity in sepsis . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The existence of an endogenous high affinity interleukin 1 receptor antagonist ( IL 1ra ) suggests that this molecule lacks some structural motif ( s ) which are present in the closely homologous agonist interleukin 1 beta ( IL 1 beta ) and which serve as the ' agonist switch ' causing signal transduction by the agonist receptor complex . ^^^ The primary sequence alignment of IL 1 beta and IL 1ra sequences from different species reveals a six amino acid long motif that is quasi conserved among IL 1 beta sequences , but is missing from the IL 1ra sequences . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1ra suppresses endotoxin induced IL 1 beta and TNF alpha release from mononuclear phagocytes . ^^^ To test this hypothesis , mononuclear cells and alveolar macrophages were stimulated with LPS in the presence of IL 1ra and analyzed for IL 1 beta and TNF alpha production . ^^^ For mononuclear cells , IL 1ra inhibited 6 h LPS and IL 1 alpha induced IL 1 beta release to 66 + / 4 % ( P = 0 . 001 by paired t test ) and 39 + / 7 % ( P = 0 . 0005 by paired t test ) of control , respectively . ^^^ In addition , IL 1ra reduced both LPS and IL 1 alpha stimulated IL 1 beta mRNA levels to 78 and 37 % of control , respectively . ^^^ Alveolar macrophages demonstrated variable IL 1ra induced suppression of LPS stimulated IL 1 beta and TNF alpha release . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
By using a mixture of neutralizing mAbs to IL 1 alpha , IL 1 beta , and to the type 1 IL 1R , we previously documented a regulatory role for IL 1 in the development of anti Listeria responses in mice . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1 receptor antagonist ( IL 1ra ) shows homology to the C terminal region of both IL 1 alpha and IL 1 beta . ^^^ In the C terminal region , the IL 1 alpha genes of human and mouse have diverged more from each other at nonsynonymous sites than have either IL 1 beta or IL 1ra ; because the same pattern is not seen at synonymous sites , it must be due not to a difference in mutation rate but rather to a greater degree of functional constraint on this region in the IL 1 beta and IL 1ra proteins than in the IL 1 alpha protein . ^^^ The first exon of the IL 1ra gene , which encodes the leader peptide , shows evidence of homology with the first exon of IL 1 beta , which is not translated . ^^^ Thus , it seems likely that IL 1ra evolved by duplication of an IL 1 beta gene and loss of expression of exons 2 4 . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We now report that EP treatment in vivo decreased the secretion into the medium of cultured monocytes of IL 1ra and IL 1 beta as well as the IL 1 beta / IL 1ra ratio . ^^^ In these women , monocyte IL 1 beta , IL 1 beta / IL 1ra ratio , and IL 1 bioactivity were all increased in the first 7 yr after the menopause and within the premenopausal range thereafter . ^^^ In osteoporotic women , IL 1 beta , IL 1 beta / IL 1ra ratio , and IL 1 bioactivity increased after the menopause and returned to premenopausal levels after 15 yr from the menopause . ^^^ We conclude that hormone replacement decreases the in vitro secretion of both IL 1ra and IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Recently , a naturally occurring interleukin 1 receptor antagonist , designated IL 1ra , which inhibits IL 1 beta activity in vitro and in vivo has been described . ^^^ The purpose of the present study was to assess the circulating levels and relative relationships of IL 1ra , IL 1 beta , and IL 6 in children with IBD of varying severity . ^^^ IL 1 beta was only detectable in the circulation of two subjects with severe colitis ( one ulcerative colitis , one Crohn ' s disease ) , and both had extremely elevated IL 1ra levels . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Inhalation of corn dust extract resulted in an acute inflammatory response characterized by higher concentrations of neutrophils ( p = 0 . 001 ) , IL 1 beta ( p = 0 . 001 ) , IL 1RA ( p = 0 . 001 ) , IL 6 ( p = 0 . 001 ) , IL 8 ( p = 0 . 001 ) , and TNF alpha ( p = 0 . 04 ) in bronchoalveolar lavage ( BAL ) fluid . mRNA levels specific for IL 1 beta , IL 1RA , IL 6 , and IL 8 from cells present in the BAL fluid were significantly greater after challenge with corn dust extract than after challenge with buffered saline . ^^^ The maximal percentage decrease in FEV 1 was significantly associated with the absolute neutrophil concentration in the BAL fluid ( p = 0 . 001 ) , as well as the concentration of TNF alpha ( p = 0 . 03 ) , IL 1 beta ( p = 0 . 005 ) , IL 1RA ( p = 0 . 001 ) , IL 6 ( p = 0 . 001 ) , and IL 8 ( p = 0 . 001 ) in the BAL fluid . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To explore this possibility , we have done a retrospective study that compared the clinical course of Lyme arthritis in 83 patients with concentrations of IL 1 beta and IL 1ra in the patients ' synovial fluid . ^^^ Patients with high concentrations of IL 1ra and low concentrations of IL 1 beta had rapid resolution of attacks of arthritis , whereas patients with the reverse pattern of cytokine concentrations had long intervals to recovery . ^^^ Thus , the balance between synovial fluid IL 1 beta and IL 1ra concentrations relates to the time to recovery from an episode of Lyme arthritis . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
ICAM 1 expression induced by IL 1 beta , rabbit IL 1 beta 208 240 and human IL 1 beta 208 240 was blocked by the IL 1ra , while TNF alpha and IFN gamma induced ICAM 1 expression were not . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Highly polymorphic sequences have been identified in the IL 1 beta , IL 1ra , IL 2 , IL 4 , IL 5 , IL 6 , IL 7 , and IFN gamma genes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
There were nonsignificant trends for increased IL 1 beta / IL 1ra and ( IL 1 alpha + IL 1 beta ) / IL 1ra ratios in the osteoporotic vs . normal women . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Stimulation with IL 1 beta or TNF alpha massively increased chemokine production and induced the generation of PGE and low amounts of IL 1ra . ^^^ The yield of IL 1ra was strongly enhanced by IFN gamma in all cases , whereas the effect of IL 4 was pronounced only in IL 1 beta stimulated OA synoviocytes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Because we hypothesize that the interleukin 1 ( IL 1 ) system may be important in the dialogue between mother and embryo during the implantation process , we have analyzed the effect of IL 1 beta , a secretory product of the human embryo and human endometrium , on the mRNA and protein levels of IL 1 receptor type 1 ( IL 1R tI ) in the human endometrium . ^^^ EEC from proliferative and secretory endometrium expressed high levels of IL 1R tI mRNA compared to ESC , and these levels were not modulated by IL 1 beta . ^^^ However , when ESC were isolated from proliferative endometrium , an up regulation of IL 1R tI ( 3 . 5 + / 0 . 5 fold increase ) was observed on days 6 and 8 of culture regardless of the presence or absence of IL 1 beta . ^^^ The constitutive presence of IL 1R tI in EEC , which was not affected by IL 1 beta , and the up regulation of IL 1R tI mRNA by its ligand IL 1 beta in ESC isolated during the luteal phase suggest a role for the IL 1 system in human implantation . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The objective of this study was to characterize interleukin 1 receptor antagonist ( IL 1ra ) and interleukin 1 beta ( IL 1 beta ) production by human peripheral blood neutrophils ( polymorphonuclear leukocytes ; PMN ) . ^^^ Unstimulated PMN contained IL 1ra protein in the absence of IL 1ra mRNA ; IL 1 beta mRNA and protein were undetectable . ^^^ IL 4 enhanced LPS induced IL 1ra production by PMN and inhibited LPS induced IL 1 beta production . by PMN and inhibited LPS induced IL 1 beta production . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 beta and IL 1ra protein secretion was evaluated by ELISA , and expression of the mRNA for the cytokines was examined by means of Northern blot analysis . ^^^ The HCMV IE1+2 gene products were found to increase expression of the mRNA for both IL 1 beta and IL 1ra ; however , only the IL 1ra protein was released in increased amounts . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We found , that : ( 1 ) the number of TCR / CD3 receptors on uremic helper inducer ( CD 4 ) T lymphocytes is decreased and correlated well with the blunted lymphocyte proliferation induced by anti CD 3 mAb ; ( 2 ) these findings were associated with diminished binding capacity of IL 1 beta and IL 6 to their receptors ( IL 1R , IL 6R ) on helper inducer T cells , whereas ( 3 ) the IL 2 receptor ( IL 2R ) and molecule expression of CD 4 and lymphocyte function antigen 1 ( LFA 1 ) were increased , and ( 4 ) uremic monocytes displayed a decreased density of intercellular adhesion molecule 1 ( ICAM 1 ) expression , which interacts as receptor ligand pair with LFA 1 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Northern blot analysis demonstrated that the IL 1ra mRNA expression increased with IL 1 beta or tumor necrosis factor ( TNF ) alpha but not with GM CSF stimulation in both LN 443 and LN 444 cell lines . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The distribution of immunoreactive interleukin 1 receptor type 1 ( IL 1R tI ) , IL 1 alpha , and IL 1 beta , and of macrophages , was investigated immunohistochemically in the mouse ovary during follicular growth , ovulation , and luteinization . ^^^ For this purpose , an indirect immunofluorescence technique , using specific monoclonal antibodies against mouse IL 1R tI , mouse IL 1 alpha , IL 1 beta , and macrophage antigens ( CD11b / CD18 ) was used with sections of paraffin embedded ovaries from eCG and eCG / hCG treated 12 wk old B6C3F 1 female mice . ^^^ During follicular development , IL 1 alpha , IL 1 beta , and IL 1R tI staining were confined to the theca interstitial layer of growing follicles with one remarkable exception . ^^^ During ovulation , IL 1 alpha and IL 1 beta were still confined to the theca layer , but faint IL 1R tI staining was initiated in cumulus cells and in granulosa cells just before follicle rupture . ^^^ Immediately after follicle rupture , granulosa cells stained positive for IL 1R tI , IL 1 alpha , and IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We examined the effects of various cytokines on monocyte IL 1ra protein production and compared it to IL 1 beta , which is regulated differently . ^^^ IL 3 and GM CSF did not affect LPS or IgG induction of IL 1ra or LPS induced IL 1 beta . ^^^ However , our data confirmed that IL 4 up regulated LPS induced IL 1ra and down regulated LPS induced IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RESULTS : All rats strains developed acute inflammation with increased cecal concentrations of IL 1 beta and IL 1ra mRNA . ^^^ IL 1 beta and IL 1ra were produced by submucosal granulomas and correlated with inflammation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1ra at concentrations achieved in the plasma during IL 2 immunotherapy ( approximately 10 ng / ml ) inhibited the in vitro production of IL 1 beta and TNF alpha by IL 2 activated PBMCs by 65 % and 30 % , respectively . ^^^ Although the monomeric receptor TNFsRp 55 at concentrations achieved in the plasma had no effect on the in vitro production of IL 1ra , TNF alpha , or IL 1 beta , the bivalent TNFsRp 75 Fc chimera suppressed the generation of TNF and IL 1 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
LPS induced pulmonary edema was partially inhibited by anti IFN gamma antibodies but not by anti TNF antibodies , anti IL 1 beta antibodies , or IL 1 receptor antagonist ( IL 1Ra ) . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Length of gestation , presence or absence of labor signs , or elevated IL 1 beta in amniotic fluid did not affect the concentration of IL 1ra in amniotic fluid . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Cells were harvested after 48 or 72 h of culture and stained for the following cytokines : interleukin ( IL ) 1 alpha , IL 1 beta , IL 1ra , IL 6 , IL 8 , IL 2 , tumor necrosis factor interferon ( IFN ) gamma and TNF alpha and TNF beta and granulocyte macrophage colony stimulating factor . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 receptor type 1 , IL 1 beta , IL 1 receptor antagonist , and human macrophages were immunohistochemically localized in the villous trophoblast , maternal trophoblast interphase , and maternal decidua during early human implantation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The cross linking of monocyte Fc gamma R is a potent stimulus for IL 1ra production but does not induce IL 1 beta . ^^^ Therefore , we analyzed the effect of combinations of Fc gamma R cross linking and bacterial cell wall components on mononuclear phagocyte IL 1 beta and IL 1ra production . ^^^ Cells cultured on immobilized IgG released large amounts of IL 1ra but no detectable IL 1 beta . ^^^ In response to LPS , mononuclear cells released IL 1ra at 1000 fold lower doses of LPS than was required to induce IL 1 beta . ^^^ However , when measured in the presence of immobilized IgG , the LPS sensitivity for IL 1 beta release increased 100 fold , whereas IL 1ra release correlated inversely with the LPS dose . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1ra levels in synovial fluids of 19 patients suffering from various inflammatory joint diseases were compared with the cytokine levels of IL 1 beta , IL 6 , IL 8 , and TNF alpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
That IL 10 selectively upregulates IL 1ra production in LPS activated PMN , while it inhibits the production of IL 1 beta , TNF , and IL 8 under the same conditions , suggests that IL 10 may be an important physiologic regulator of cytokine production from PMN , and emphasizes the potential role of IL 10 in inflammatory responses . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1ra has the same overall beta trefoil fold as IL 1 alpha and IL 1 beta and has a very similar hydrophobic core . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1ra and IL 1 beta gene expression was assessed by Northern blot analysis of PBMNC mRNA . ^^^ Gene expression of IL 1ra was first detected at 2 hours , lagging behind that of IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1ra has recently been shown to suppress both cytokine and endotoxin induced IL 1 beta and TNF alpha release from monocytes . ^^^ Given that mononuclear phagocytes can produce both the proinflammatory cytokines IL 1 alpha , IL 1 beta , and TNF alpha as well as the suppressive cytokine IL 1ra , we proposed that IL 1 alpha , IL 1 beta , and TNF alpha may induce IL 1ra from mononuclear phagocytes . ^^^ To test this hypothesis , human mononuclear cells were stimulated for 18 h with IL 1 alpha , IL 1 beta , or TNF alpha , and the supernatants assayed for IL 1ra by ELISA . ^^^ However , IL 1 alpha and IL 1 beta were better inducers of IL 1ra than was TNF alpha . ^^^ IL 1 alpha or IL 1 beta at a dose of 10 ng / ml induced 3 to 6 ng / ml of IL 1ra , while TNF alpha at a dose of 100 ng / ml stimulated only 1 . 4 ng / ml of IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 alpha , IL 1 beta , and IL 1ra protein levels were measured by enzyme linked immunosorbent assay in fresh and cultured ST cells , purified synovial macrophages , and fibroblast like synoviocytes ( FLS ) . ^^^ IL 1 alpha , IL 1 beta , and IL 1ra were present in fresh and cultured ST cell samples of synovium from RA and osteoarthritis patients . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
LPS stimulates human monocytes and neutrophils to produce IL 1 beta and IL 1 receptor antagonist ( IL 1ra ) . ^^^ The objective of these studies was to examine the effects of IL 10 on human monocyte and neutrophil IL 1ra protein and mRNA production and compare it to IL 1 beta . ^^^ These net effects of IL 10 resulted in an increase in the ratio of IL 1ra to IL 1 beta in both neutrophils and monocytes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present study , plasma levels of IL 1 beta , IL 1Ra , TNF alpha and TNFsRp 55 were measured in 29 undialyzed patients with chronic renal failure ( CRF ) , 13 patients on continuous ambulatory peritoneal dialysis ( CAPD ) , 42 patients on chronic hemodialysis ( HD ) and in 15 healthy controls . ^^^ Among health controls , plasma levels of IL 1 beta , IL 1Ra and TNF alpha were at or below the limit of detection of the assay . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Cross linking 125I IL 1 beta to the IEC 18 IL 1R demonstrated an IL 1R of approximately 80 . 5 kDa . cDNA transcribed from IEC 18 mRNA was used as a template for amplification of a segment of the IL 1R using complementary oligonucleotides . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Lipopolysaccharide stimulation induced extensive production of the following monokines : IL 1 alpha , IL 1 beta , IL 1ra , IL 6 , IL 8 , and tumor necrosis factor alpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The pattern of TNF alpha mRNA induction is different from that observed for mRNAs of IL 1 alpha and IL 1 beta , IL 1ra and IL 6 respectively . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Quantitative evaluation of gene expression of IL 1 beta and IL 1 receptor antagonist ( IL 1ra ) from alveolar macrophages in idiopathic pulmonary fibrosis ( IPF ) and sarcoidosis ] . ^^^ The expression of IL 1 beta , IL 1ra and a house keeping gene ( glucose 6 phosphate dehydrogenase : G6PD ) was investigated using reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ IL 1ra / IL 1 beta ratio was decreased in patients with IPF and sarcoidosis , compared to HNS . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Intraperitoneal administration of OL 2 ( 250 micrograms / mouse ) expressed all three genes of IL 1 alpha , beta , and IL 1 receptor antagonist ( IL 1ra ) in the peritoneal exudate cells , while SPG induced a strength of IL 1 alpha mRNA comparable to that by OL 2 but a weaker level of IL 1 beta mRNA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Indirect immunofluorescence experiments demonstrate that IL 1R tI is located in mouse endometrial lumenal epithelium with increased intensity in the periimplantation period , whereas IL 1 beta staining is located in the mouse placenta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
AM were cultured for 24 h and assays for IL 1 beta and IL 1ra were done using sensitive and specific enzyme linked immunosorbent assay . ^^^ The IL 1 beta : IL 1ra ratio ( IL 1 beta activity index [ IL 1AI ] ) was significantly lower in supernatants of normal macrophages compared with macrophage supernatants from individuals with ILD . ^^^ Current smoking was associated with lower IL 1 beta and IL 1ra release in ILD . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 receptor antagonist ( IL 1ra ) is a recently described competitive inhibitor of IL 1 alpha and IL 1 beta that binds to human types 1 and 2 IL 1 receptors without apparent cell activation . ^^^ Human keratinocytes synthesize IL 1ra , IL 1 alpha , and IL 1 beta but fail to secrete these cytokines . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Plasma IL 1 beta reached maximal concentrations at 180 min of 364 + / 71 pg / ml in vehicle treated animals but only 145 + / 12 pg / ml in rabbits given IL 1ra ( P < 0 . 05 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In this study we have determined that IL 1 receptor type 1 ( IL 1R tI ) is expressed at the messenger RNA ( mRNA ) and protein levels in glandular cells and its ligand , IL 1 beta has been localized by immunohistochemical methods in endothelial cells and isolated stromal cells in the human endometrium throughout the menstrual cycle . ^^^ The detection of IL 1R tI in the human endometrial epithelium and its ligand , IL 1 beta , in isolated stromal cells and endothelial cells , is another example of possible communication between the immune and reproductive systems with special relevance to human implantation . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Production of IL 1 beta peaked at 6 h ( 196 . 7 + / 89 . 4 pg / joint ) after injection of 10 ng of LPS , while IL 1Ra peaked at 9 h ( 34 . 5 + / 13 . 4 ng / joint ) . ^^^ Both IL 1 beta and IL 1Ra were mainly produced by synovial exudate cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In this study , the production of cytokines IL 1 beta , tumour necrosis factor alpha ( TNF alpha ) , IL 6 and the naturally occurring inhibitor of IL 1 , IL 1Ra , have been investigated in infants and children undergoing Swenson ' s pull through operation for Hirschsprung ' s disease . ^^^ This study demonstrates , in vivo , the independent induction of IL 1Ra without a concomitant increase of IL 1 beta levels after major surgery . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We studied the hemodialysis induced changes in the in vitro production of interleukin 1 receptor antagonist ( IL 1Ra ) and interleukin 1 beta ( IL 1 beta ) by peripheral blood mononuclear cells ( PBMCs ) , and compared the effect of first use and reuse of cuprophan membranes on these changes . ^^^ The cell content and production of IL 1Ra and IL 1 beta by unstimulated and endotoxin or IgG stimulated PBMCs were studied just prior to dialysis , and from the afferent and efferent limbs of the blood circuit 15 minutes after the start of dialysis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The addition of IL 1 beta induces IL 6 mRNA , and anti IL 1 antibodies or an IL 1R antagonist protein completely suppresses IL 6 and TNF alpha supported proliferation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1ra is a member of the IL 1 family by three criteria : amino acid sequence homology of 26 to 30 % to IL 1 beta and 19 % to IL 1 alpha ; similarities in gene structure ; and common gene localization to human chromosome 2q14 . ^^^ IL 1ra production by monocytes , macrophages , and neutrophils may be regulated in a differential fashion with IL 1 beta . ^^^ IL 1ra competitively inhibits binding of both IL 1 alpha and IL 1 beta to cell surface receptors without inducing any discernible intracellular responses . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Recently , a 22 kDa natural inhibitor to IL 1 called interleukin 1 receptor antagonist ( IL 1ra ) has been described in human fluids , which specifically binds IL 1 alpha or IL 1 beta receptors . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Neutrophil ( PMN ) accumulation induced by interleukin 1 beta ( IL 1 beta , 5 20 ng ) into the mouse air pouch was inhibited in a dose dependent manner ( 2 200 micrograms ) by concomitant injection of IL 1 receptor antagonist ( IL 1RA ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Rat ovarian cells were metabolically labeled with [ 35S ] sulfate and [ 3H ] glucosamine for 48h in the absence or presence of IL 1 beta , with or without an IL 1 receptor antagonist ( IL 1ra ) . ^^^ The concurrent provision of IL 1ra ( 5 micrograms / ml ) all but neutralized the IL 1 beta effect on HA biosynthesis thereby suggesting mediation by specific ovarian IL 1 receptor ( s ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 6 secretion was induced by IL 1 beta in a concentration as low as 1 10 10 ( 10 ) M ( p = 0 . 0008 ) ; addition of IL 1Ra was shown to inhibit IL 1 induced changes by 87 % ( p = 0 . 0012 ) at a molar ratio of 100 : 1 , and by 100 % at a molar ratio of 1 , 000 : 1 , LPS stimulated IL 6 secretion progressively over the concentration of 1 100 ng / ml ( p = 0 . 0001 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Comparison of in vitro kinetics of IL 1ra , IL 1 alpha , and IL 1 beta analyzed during culture in the presence or absence of phorbol myristate acetate revealed that their mRNA expression was asynchronous . ^^^ IL 1 alpha and IL 1 beta mRNA were expressed after as little as 15 min , whereas IL 1ra mRNA was detectable only after 3 h in culture . ^^^ The production of IL 1ra was measured by enzyme linked immunosorbent assay and compared with that of IL 1 alpha and IL 1 beta . ^^^ In freshly isolated AM ( 10 ( 6 ) / ml ) , cell associated IL 1ra was present in an average amount of 2 . 0 + / 0 . 5 ng / ml , i . e . , 25 and 100 times more than IL 1 alpha and IL 1 beta , respectively . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
By contrast IL 1 beta , interferon ( IFN ) gamma and chemotactic factors ( fMLP , C5a and IL 8 ) failed to promote IL 1ra expression in PMN . ^^^ Secretion of IL 1ra was induced in PMN treated with LPS , IL 4 and GM CSF , but not by IL 1 beta , IFN gamma and fMLP , thus yielding results that paralleled those seen in Northern blot experiments . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The antisecretory effect of IL 1 beta ( 100 ng ) injected into the lateral ventricle of pylorus ligated rats was completely reversed by prior intracerebroventricular injection of the IL 1 receptor antagonist , IL 1ra , ( 100 micrograms ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 receptor antagonist ( IL 1ra ) inhibited the stimulation of amnion cell PGE 2 production by IL 1 beta , but not by TNF alpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Inhibition studies demonstrated that only IL 1 beta could compete for the binding of radiolabeled IL 1 beta to the B cell IL 1R . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In this study , we show that the addition of TGF beta to human peripheral blood monocytes induced the sequential transcription of the 1 . 8 kb mRNA for IL 1 beta and for IL 1ra . ^^^ The expression of detectable mRNA and synthesis of IL 1 beta peptide routinely preceded that for IL 1ra , suggesting possible dependency of IL 1ra generation on IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We evaluated bronchoalveolar lavage ( BAL ) fluid and BAL macrophages from 22 CF patients and 13 healthy control ( HC ) subjects , measuring soluble TNF alpha , IL 1 beta , IL 6 , and IL 8 and the regulatory molecules TNF soluble receptor ( TNF sR ) , IL 1 receptor antagonist ( IL 1Ra ) , and IL 10 ( cytokine synthesis inhibitory factor ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
There is evidence suggesting the importance of the interleukin 1 receptor type 1 ( IL 1Rtl ) and interleukin 1 beta ( IL 1 beta ) as mediator in local intercellular interactions in endometrial tissue and embryonic implantation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 beta ( IL 1 beta ) , a putative mediator of LH action , enhances both trkA and NGF gene expression in ovarian cells , an effect prevented by IL 1ra , a natural IL 1 beta receptor antagonist . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Adhesion of Plasmodium falciparum infected erythrocytes to human cells and secretion of cytokines ( IL 1 beta , IL 1RA , IL 6 , IL 8 , IL 10 , TGF beta , TNF alpha , G CSF , GM CSF . ^^^ Nine out of 17 cytokines tested were found to be secreted into the culture supernatants after 35 h of co cultures containing monocytes or unfractionated peripheral blood mononuclear cells ( PBMC ) and parasites ( IL 1RA , IL 6 , IL 8 , IL 10 , TGF beta , TNF alpha , G CSF , IL 1 beta , and GM CSF ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The production of cytokines at the single cell level was found to be dominated by tumor necrosis factor ( TNF ) alpha , interleukin ( IL ) 2 , IL 4 , IL 5 , IL 10 , IL 12 , interferon ( IFN ) gamma , granulocyte macrophage colony stimulating factor , and transforming growth factor beta , whereas IL 1 alpha , IL 1ra , IL 1 beta , TNF beta , IL 3 , IL 6 , and IL 8 were undetectable . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Fourteen cytokines were assayed ; interleukin 1 alpha ( IL 1 alpha ) , IL 1 beta , IL 1 receptor antagonist ( IL 1ra ) , IL 2 , IL 3 , IL 4 , IL 5 , IL 6 , IL 8 , IL 10 , interferon gamma ( IFN gamma ) , tumour necrosis factor alpha ( TNF alpha ) , TNF beta and granulocyte macrophage colony stimulating factor ( GM CSF ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Acute phase levels of C reactive protein enhance IL 1 beta and IL 1ra production by human blood monocytes but inhibit IL 1 beta and IL 1ra production by alveolar macrophages . ^^^ C reactive protein ( CRP ) , the major acute phase protein in humans , was purified free of endotoxin ( LPS ) ( < 10 pg of LPS / mg of purified CRP ) and evaluated for its ability to modulate LPS induced production of IL 1 beta and IL 1 receptor antagonist ( IL 1ra ) from human PBMC and lung macrophages . ^^^ Macrophages ( 10 ( 6 ) / ml ) were not stimulated to produce IL 1 beta or IL 1ra by CRP alone . ^^^ When combined with LPS , CRP inhibited IL 1 beta and IL 1ra release induced by LPS ( for IL 1 beta release , LPS induced 3 . 0 + / 1 . 7 ng / ml vs 1 . 1 + / 0 . 4 for combined LPS and CRP ; for IL 1ra release , LPS induced 12 . 9 + / 2 . 3 ng / ml vs 7 . 6 + / 2 . 3 ng / ml for combined LPS and CRP ) . ^^^ CRP may be largely proinflammatory to blood monocytes responding to LPS since IL 1 beta production is augmented over IL 1ra production . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The study of different cytokine concentrations in the synovial fluid in 83 patients with Lyme ' s arthritis showed that chronicity of arthritis depends on IL 1b and IL 1ra balance . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The present study assessed the relationship of mucosal IL 1ra levels to histologic severity of inflammation and the related proinflammatory cytokines IL 1 beta and IL 6 in children with inflammatory bowel disease . ^^^ Colonic biopsy specimens from 29 patients with ulcerative colitis , 27 with Crohn ' s disease , and 24 noninflammatory control subjects were assayed for IL 1ra , IL 1 beta , and IL 6 by enzyme linked immunosorbent assay . ^^^ Mucosal IL 1 beta levels , but not IL 1ra levels , were significantly elevated in moderate / severely inflamed biopsies from patients with either ulcerative colitis ( p < 0 . 01 ) or Crohn ' s disease ( p < 0 . 001 ) compared with those with none / mild inflammation . ^^^ The mucosal molar ratio of IL 1ra / IL 1 beta was significantly lower for moderate / severe inflammation compared with none / mild inflammation for patients with ulcerative colitis ( p < 0 . 05 ) and Crohn ' s disease ( p < 0 . 01 ) . ^^^ The mucosal IL 1ra / IL 1 beta ratio was similar in controls to none / mild inflamed biopsies from subjects with either ulcerative colitis or Crohn ' s disease . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We examined the ability of rIL 13 to regulate rIL l alpha induced IL 1 beta , IL 1 receptor antagonist ( IL 1ra ) and IL 8 production in cultured peripheral blood mononuclear cells ( PBMC ) , endothelial cells and fibroblasts . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Endurance run increases circulating IL 6 and IL 1ra but downregulates ex vivo TNF alpha and IL 1 beta production . ^^^ Exercise induced a decrease of LPS stimulated production of IL 1 beta and TNF alpha , whereas production of IL 1ra was unchanged . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In this study cultured human peripheral blood mononuclear cells were polyclonally stimulated and then analyzed for interleukin 1alpha ( IL 1alpha ) , IL 1beta , IL 1ra , IL 2 , IL 4 , IL 6 , IL 8 , IL 10 , tumor necrosis factor alpha ( TNF alpha ) , TNF beta , interferon gamma , granulocyte colony stimulating factor and granulocyte macrophage colony stimulating factor production . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present report , plasma IL 1beta , IL 1ra , and soluble IL 1RI and IL 1RII concentrations were evaluated in 118 patients with sepsis syndrome or after elective operative trauma . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Like IL 4 , IL 13 induces IL 1 receptor antagonist ( IL 1Ra ) synthesis with no effect on IL 1beta synthesis . ^^^ Furthermore , IL 13 reduced steady state levels for IL 1beta mRNA but enhanced those for IL 1Ra mRNA in cells stimulated with lipopolysaccharide ( LPS ) or IL 1alpha . ^^^ Accordingly , IL 13 suppressed IL 1beta synthesis but enhanced IL 1Ra synthesis in these cells . ^^^ IL 13 reduced the stability of IL 1beta mRNA ( 2 . 9 5 1 . 7 hours ) but failed to modify the stability of IL 1Ra mRNA ( 2 . 7 5 2 . 5 hours ) . ^^^ Moreover , IL 13 induced transcriptional activation of the IL 1Ra gene , but reduced IL 1beta gene transcription . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Circulating levels of proinflammatory cytokines ( tumor necrosis factor alpha ( TNF alpha ) interleukin 1 beta [ IL 1 beta ] , IL 2 , IL 6 , and interferon gamma [ IFN gamma ] ) , anti inflammatory cytokines ( transforming growth factor beta 1 [ TGF beta 1 ] , IL 4 , IL 10 , and IL 13 ) , the cytokine carrier protein alpha 2 macroglobulin , IL 1 receptor antagonist ( IL 1ra ) , soluble TNF receptors ( sTNFr ) p 55 and p 75 , and soluble IL 6 receptor ( sIL 6r ) were determined in 15 patients with POEMS syndrome and 15 with multiple myeloma . ^^^ IL 1ra and sTNFrs were increased in POEMS syndrome , but out of proportion to the increase of IL 1 beta and TNF alpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Significance of IL 1beta and IL 1 receptor antagonist ( IL 1Ra ) in bronchoalveolar lavage fluid ( BALF ) in patients with diffuse panbronchiolitis ( DPB ) . ^^^ IL 1Ra in patients is considered to have a weak inhibitory activity for IL 1beta , with approximately five fold concentration of IL 1beta compared with that in healthy volunteers ( approx . nine fold concentration of IL 1beta ) . ^^^ The level of IL 1beta correlated significantly with the concentration of neutrophils in BALF ( r=0 . 72 , P < 0 . 01 ) , as well as with the level of IL 1Ra ( r=0 . 688 , P < 0 . 05 ) and IL 8 ( r=0 . 653 , P < 0 . 05 ) . ^^^ Our results suggest that the relative amounts of IL 1beta and IL 1Ra or IL 8 may contribute , at least in part , to the neutrophil mediated chronic airway inflammation in patients with chronic airway disease , and long term erythromycin therapy may down regulate the vigorous cycle between the cytokine network and neutrophil accumulation , with resultant reduction of neutrophil mediated inflammatory response . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In this regard , anti inflammatory cytokines inhibited LPS plus GM CSF stimulated HIV expression , and this effect closely correlated with inhibition of IL 1 beta release and , in particular , with up regulation of endogenous IL 1ra production . ^^^ Thus , the balance between an endogenously produced viral inducer ( IL 1 beta ) and an inhibitor ( IL 1ra ) may represent an important pathway leading to modulation of HIV expression from monocytic cells . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 alpha and IL 1ra , but not IL 1 beta , were detected in the tape stripped stratum corneum of healthy volunteers by enzyme linked immunosorbent assays . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Monokine production ( IL 1 alpha , IL 1 beta , IL 1ra , IL 6 and IL 8 ) was either unaffected or even increased . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Mice deficient in IL 1Beta , IL 1Beta converting enzyme , and IL 1R type 1 have also been studied . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Immunohistochemistry showed that EBP and IL 1 receptor type 1 codistributed on surfaces of unstimulated coronary artery SMC , while CS and kappa El dependent removal of EBP from the cell surface increased binding of radiolabeled IL 1beta to CA SMC . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Whereas the in vivo regulatory effects of IL 1R appear to be limited to IL 1beta , IL 10 regulates both IL 1beta and TNF alpha in this model , reflected by a 48 % increase in BAL IL 1beta in rats treated with anti IL 10 . ^^^ These findings suggest that IL 1Ra is an intrinsic regulator of inflammatory injury after deposition of IgG immune complexes and that it regulates production of IL 1beta . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Here we have assayed the serum levels of the members of the IL 1 ligand family , the two agonists IL 1 alpha and IL 1 beta and the antagonist IL 1 receptor antagonist ( IL 1ra ) , in nine children with HLH and cerebrospinal fluid ( CSF ) specimens from four children . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In a second set experiments , we found that the genes encoding not only ICE , but also IL 1 alpha , IL 1 beta , IL 1 receptor antagonist ( IL 1ra ) , and the IL 1 type 1 receptor are expressed in brain vasculature . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : Soluble IL 1 type 2 receptor and the cytokines IL 1 beta , IL 1ra , IL 3 , IL 5 , granulocyte macrophage colony stimulating factor , and tumor necrosis factor alpha were measured in serum and in bronchoalveolar lavage fluid from two patients with acute eosinophilic pneumonia during both acute and convalescent phases . ^^^ RESULTS : Compared with patients with adult respiratory distress syndrome , the patients with acute eosinophilic pneumonia had high bronchoalveolar lavage fluid levels of IL 5 , IL 1ra , and soluble type 2 IL 1 receptor but not IL 1 beta , tumor necrosis factor alpha , IL 3 , or granulocyte macrophage colony stimulating factor . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We studied the induction of interleukin 1 beta ( IL 1 beta ) by plasma samples taken from the blood compartment as well as the induction of IL 1 beta and interleukin 1 receptor antagonist ( IL 1Ra ) in mononuclear cells separated from whole blood after circulation by radioimmunoassay and polymerase chain reaction . ^^^ Mononuclear cells separated after contaminated dialysis will all types of dialysers expressed increased mRNA levels for IL 1 beta and IL 1Ra . ^^^ The detection of cytokine mRNA as well as the measurement of IL 1Ra synthesis is a more sensitive marker for the transfer of cytokine inducing substances through dialyser membranes than the measurement of IL 1 beta protein synthesis . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Blocking IL 1 receptors in HSE by addition of 100 ng / mL IL 1 receptor antagonist ( IL 1Ra ) before stimulation with LPS or IL 1beta abrogated the increase in mannose receptor mediated uptake . ^^^ Upregulation of mannose receptor mediated uptake in response to IL 1beta or LPS was also blocked by previous addition of IL 1Ra to rat HSE . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Plasma endotoxin , tumor necrosis factor alpha ( TNF alpha ) , interleukin 1 beta ( IL 1 beta ) , interleukin 1 receptor antagonist ( IL 1ra ) , and interleukin 6 ( IL 6 ) concentrations in 69 bacteremic patients were compared with those in 54 nonbacteremic patients suffering from suspected bacterial infections . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We have studied the effects of several interleukin 1 ( IL 1 ) inhibitors IL 1 receptor antagonist ( IL 1ra ) , soluble IL 1 receptor ( sIL 1R ) types 1 and 2 , and neutralizing monoclonal antibody ( mAb ) specific for IL 1 receptor type 1 on the osteoclast activating factor ( OAF ) activity of recombinant IL 1beta and of culture supernatants of unfractionated bone marrow mononuclear cells from multiple myeloma ( MM ) patients . ^^^ IL 1ra and sIL 1R types 1 and 2 had a clear cut modulating effect on the OAF activity of IL 1beta at saturating doses ( 2 10 ng / mL ) ; their effect was evident at 2 ng / mL and was dose dependent over a large range of concentrations . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The isolated IEL population contains mRNA for IL 1 alpha , IL 1 beta , IL 1R , IL 1RA , IL 2 , IL 6R , IFN gamma , TGF alpha , TGF beta 1 , and TNF alpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The ECLA procedure induced the appearance of tumor necrosis factor alpha ( TNF alpha ) and interleukin 1 ( IL 1 ) receptor antagonist ( IL 1Ra ) in plasma , but not IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 alpha and IL 1 beta caused a similar increase in AML blast release of IL1RA , and addition of anti IL 1 antibodies decreased IL1RA release . ^^^ Serum levels of both IL1RA as well as IL 1 beta and soluble TNF alpha receptors increased when the leucopenic patients developed complicating bacterial infections . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Plasma from 27 women with silicone breast implants ( SBIs ) and 50 age matched control women without SBIs were examined by enzyme immunoassay for the presence of interleukin 1 beta ( IL 1 beta ) and its naturally occurring receptor antagonist , IL 1ra . ^^^ In contrast to the IL 1ra results , the frequency of elevated IL 1 beta concentrations among women with SBIs was only 40 % ( 11 of 27 ) , but this was significantly higher than the 0 % ( 0 of 50 ) in control women without SBIs . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Neither intraperitoneal ( ip ) injection of IL 1Ra or IL 1 beta had any effect on the generation of the protein . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The deleterious effects of IL 1 beta , a cytokine involved in inflammation and host defense , are blocked by IL 1 receptor antagonist ( IL 1Ra ) . ^^^ To determine the relative antigen concentrations of IL 1 beta and IL 1Ra and functional IL 1 activity in lung lavage of infants at risk for BPD , lung lavage was serially obtained from 1 to 28 days from 17 infants with evolving BPD , 13 infants with self limited RDS , and 6 controls ventilated for nonpulmonary reasons . ^^^ IL 1 beta / IL 1Ra antigen ratio was significantly higher on days 5 ( median 0 . 024 ) and 7 ( median 0 . 025 ) compared with day 1 ( median 0 . 004 ) , p < 0 . 05 . ^^^ These results suggest that a relative imbalance of IL 1 beta and IL 1Ra may contribute to prolonged inflammation in BPD . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We performed immunohistochemical staining of IL 1 beta , interleukin 1 receptor ( IL 1r ) and interleukin 4 ( IL 4 ) in the nasal tissue , and evaluated serum levels of the biochemical mediators involved in the inflammation regulatory mechanism : IL 1 beta , IL 4 , interleukin 1 receptor antagonist ( IL 1ra ) , IgE , cortisol , and ACTH before , during , and after allergen provoked rhinitis in pollinosis sufferers . ^^^ Our morphological study showed that , even before the pollen season , large amounts of IL 4 and IL 1r , exclusive of IL 1 beta , were produced in the nasal tissue of patients with seasonal pollinosis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The effects of the cytokine , interleukin 1 beta ( IL 1 beta ) , and its receptor antagonist IL 1ra , were studied on long term potentiation in the dentate gyrus of rat hippocampal slices . ^^^ Co application of IL 1 beta and IL 1ra ( 100 ng / ml ) attenuated the inhibitory effect of IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We examined the mRNA levels for various cytokines , including IL 1 alpha , IL 1 beta , TNF alpha , TGF beta 1 , GM CSF , IL 6 , IL 8 , bFGF , PDGF A , PDGF B and IL 1ra , and IL 1 beta converting enzyme , and the protein levels of some of these cytokines in 19 SV 40 transformed synovial cell clones . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Retinoic acid regulates differentially the expression of IL 1 beta and IL 1 receptor antagonist ( IL 1ra ) in PMA activated human monocytes . ^^^ Although it has been shown that RA stimulates IL 1 expression in monocytes , it is of interest for understanding of the regulatory role of RA in inflammation to examine whether RA also modulates the expression of the IL 1 receptor antagonist ( IL 1ra ) , which is reported to reduce IL 1 beta mediated inflammation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 alpha ( IL 1 alpha ) and IL 1 beta bind to either the p 80 type 1 IL 1 receptor ( IL 1RI ) or the p 68 type 2 IL 1R ( IL 1RII ) on both T and B lymphocytes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Differential expression of IL 1 beta and IL 1ra resulting in a high IL 1 beta to IL 1ra ratio in response to mixed matrices containing FN and type 1 collagen may be an important regulatory point in inflammation . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We describe herein the generation and properties of a natural IgG4 / kappa anti IL 1 alpha monoclonal autoantibody , HuMAb X 3 , that bound specifically to human IL 1 alpha , but not to IL 1 beta and IL 1Ra , with a high affinity ( Kd = 1 . 2 10 10 ( 10 ) M ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We also demonstrate that Ice , when expressed in COS cells , requires the coexpression of pro IL 1 beta for the induction of apoptosis , which is inhibited by IL 1Ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Therefore , we tested whether IgD , IgG and alpha 1 acid glycoprotein ( AGP ) isolated from human serum influence the synthesis of interleukin 1 beta ( IL 1 beta ) , tumour necrosis factor alpha ( TNF alpha ) , and IL 1ra , as measured by specific radioimmunoassays , in human peripheral blood mononuclear cells ( PBMC ) . ^^^ These data indicate that IgD is a potent inducer of TNF alpha , IL 1 beta and IL 1ra and thus may contribute to the pathogenesis of HIDS . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
CONCLUSION : Tumour necrosis factors alpha , IL 1 beta , IL 6 , IL 8 and IL1ra were markedly elevated in tracheobronchial aspirate fluids from neonates with bronchopulmonary dysplasia . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
I . v . pretreatment of the animals with recombinant human IL 1 receptor antagonist ( IL 1ra ) significantly blocked the plasma B response to i . v . treatment with IL 1 beta , whereas the TNF alpha and IL 6 induced increases in plasma B levels were not affected . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1 system , consisting of two agonists ( IL 1 alpha and IL 1 beta ) , two receptors ( IL 1R types 1 and 2 ) and the homologous IL 1 receptor antagonist ( ra ) , has also been studied . ^^^ IL 1R type 1 is plentiful on endometrial epithelial cells and appears to interact with embryonically secreted IL 1 beta to favour implantation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1 receptor antagonist ( IL 1ra ) injected intravenously ( 3 micrograms / rat ) or intracisternally ( 100 ng / rat ) reversed the IL 1 beta induced 47 % inhibition of gastric emptying by 100 % and 62 % , respectively . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Of the cytokines tested , IFN gamma and TNF alpha were the best costimuli for IL 1ra production in the presence of zymosan , whereas IL 1beta , IL 10 , and IL 12 were not active . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The cytokine interactions are unidirectional , in that neutralization of TNF alpha reduced IL 1 beta , IL 6 and IL 8 production , whereas treatment of the rheumatoid synovial membrane cells with a neutralizing concentration of the IL 1 receptor antagonist ( IL 1ra ) reduced IL 6 and IL 8 production but not TNF alpha production . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The localization and production at the single cell level of 19 different human cytokines , IL 1 alpha , IL 1 beta , IL 1ra , IL 2 , IL 3 , IL 4 , IL 5 , IL 6 , IL 8 , IL 10 , IL 13 , TNF alpha , TNF beta , IFN gamma , GM CSF , G CSF , and TGF beta 1 3 , were studied in cryopreserved tonsillar tissue using immunohistochemical staining . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The filter paper was transferred to a buffer solution , and IL 1 beta and IL 1ra were assessed using ELISA . ^^^ Positive correlations between endoscopic grading and In ( IL 1 beta ) ( P < 0 . 0001 ) and In ( IL 1ra ) ( P < 0 . 001 ) and a negative correlation between endoscopic grading and In ( IL 1ra / IL 1 beta ) ( P < 0 . 02 ) were found . ^^^ In measurements during and after a flare up no significant change in IL 1ra but a significant decrease in IL 1 beta was detected , which is in agreement with investigations on biopsies . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 receptor antagonist ( IL 1Ra ) levels as well as IL 1 beta and interferon gamma ( IFN gamma ) levels were measured by enzyme immunoassay in pleural effusions from 70 patients . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IgA induced higher levels of IL 1Ra than Haemophilus influenzae type b ( Hib ) expressing lipopolysaccharide ( LPS ) , purified LPS or phorbol myristate acetate ( PMA ) , without induction of IL 1 beta release , and even inhibited LPS induced IL 1 beta release . ^^^ By the induction of IL 1Ra and down regulation of the release of inflammatory cytokines such as IL 1 beta , TNF alpha and IL 6 , interaction of IgA with human monocytes may actively contribute to the regulation of the inflammatory response . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : Northern hybridization of the transcript expression of type 1 cytokine receptors ( EGFR , IL 1R , and PDGFR beta ) , type 2 cytokines ( bFGF , LIF , and TGF beta 1 ) , and type 3 cytokines ( HGF and KGF ) by human corneal and limbal fibroblasts was conducted under the modulation of TGF alpha , PDGF BB , IL 1 beta , and EGF ( type 1 cytokines ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In resting and cytokine stimulated MNC , IL 13 markedly inhibited IL 1 beta , IL 8 and monocyte chemoattractant protein 1 ( MCP 1 ) release and potently stimulated interleukin 1 receptor antagonist ( IL 1ra ) synthesis . ^^^ In contrast , IL 12 stimulated the production of IL 1 beta and MCP 1 in TNF alpha stimulated MNC and inhibited IL 1ra synthesis in cytokine stimulated cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We measured systemic serum levels of interleukin 1 receptor antagonist ( IL 1ra ) , interleukin 1 beta ( IL 1 beta ) , tumor necrosis factor alpha ( TNF alpha ) , and interleukin 6 ( IL 6 ) during the preoperative , anhepatic , and postreperfusional phases up to the 7th postoperative day in 60 patients undergoing orthotopic liver transplantation ( LTx ) . ^^^ In contrast to IL 1 beta , IL 1ra , TNF alpha , and IL 6 showed a significant elevation in relation to the early phase after reperfusion , while TNF alpha displayed a high grade of scatter . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Crosslinking of sIL 1R to ( 125 ) 1 IL 1 beta could be competed with unlabelled IL 1 alpha , IL 1 beta , IL 1 receptor antagonist ( IL 1ra ) , and a mutant of IL 1 ( Th9Gly ) which has reduced bioactivity but wild type receptor binding affinity . ^^^ Limited proteolysis of sIL 1R in the presence of IL 1 alpha , IL 1 beta , IL 1ra , and Thr9Gly IL 1 beta with several different proteases followed by analysis of sIL 1R by Western blot was used to assess the effect of binding on sIL 1R conformation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : To measure circulating interleukin 1 beta ( IL 1 beta ) and IL 1 receptor antagonist ( IL 1Ra ) levels in patients with systemic juvenile chronic arthritis ( JCA ) and to evaluate their correlation with disease activity . ^^^ METHODS : IL 1 beta and IL 1Ra levels were measured by ELISA in 45 patients with JCA ( 20 systemic , 10 polyarticular and 15 pauciarticular ) and in 15 healthy controls . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The following primary antibodies were used : monoclonal mouse anti human IL 1 receptor type 1 ( IL 1R tl ) , monoclonal mouse anti human IL 1 beta , and polyclonal rabbit anti human IL 1 receptor antagonist ( IL 1ra ) . ^^^ Immunostaining confirmed the presence of IL 1 beta , IL 1ra , and IL 1R tl in oocytes and embryos in all stages analyzed , with no statistical differences . ^^^ IL 1 alpha , IL 1 beta , and IL 1ra levels were determined by ELISA in the 24 h culture or coculture conditioned media . ^^^ IL 1 alpha , IL 1 beta , and IL 1ra were absent in conditioned media of cultured embryos and embryos cocultured with ESC . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 4 , IL 10 , TGF beta , and glucocorticoids ( GC ) all suppress the lipopolysaccharide ( LPS ) stimulated release of TNF alpha and IL 1beta but vary in their effects on IL 1RA and sTNF R . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The aim of the study was to investigate inflammatory cytokines , interleukin 1 beta ( IL 1 beta ) , interleukin 1 receptor antagonist ( IL 1ra ) , IL 6 , IL 8 in amniotic fluid , in a cohort of Swedish pregnant women from early to late pregnancy and Mozambican late pregnant women with and without signs of histologic chorioamnionitis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Soluble IL 1RI decreased IL 1 beta ( P = . 001 ) , but decreased IL 1ra ( P = . 0001 ) , and resulted in 10 fold and 43 fold dose related increases in sIL 1RI IL 1ra complexes compared with placebo ( P < or = . 001 ) . ^^^ Thus , sIL 1RI had no discernable antiinflammatory effect following endotoxin administration due in part to low levels of circulating IL 1 beta and neutralization of IL 1ra inhibitory function . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : Umbilical cord interleukin 1 beta ( IL 1 beta ) and IL 1ra were measured in 24 normal appropriately grown newborns delivered vaginally ( VD group ) , 10 normal appropriately grown newborns delivered by elective cesarean section ( ECS group ) , and 5 appropriately grown newborns with fetal distress ( FD group ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Moreover , HIV 1 Tat at a concentration of 10 micrograms / ml was found to have a strong suppressive effect on DNA synthesis and IL 1 beta production , but stimulates secretion of IL 1 receptor antagonist ( IL 1RA ) and TNF alpha of CD 26 expressing U 937 H cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The data suggest the operation of an IL 1 beta feedback system ( IL 1 beta / IL 1RI / IL 1RII / IL 1Ra ) within a brain region . ^^^ The fine regulation of the CNS IL 1 beta system may depend on a balance between the ligand ( IL 1 beta ) action on the IL 1RI and the induction of inhibitory mechanisms ( IL 1RII and IL 1Ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Expression of interleukin 1 beta ( IL 1beta ) and interleukin 1 receptor antagonist ( IL 1ra ) on asthmatic bronchial epithelium . ^^^ In this study we looked at the expression of interleukin 1 beta ( IL 1beta ) and its naturally occurring receptor antagonist , IL 1ra , in the normal and asthmatic bronchial wall . ^^^ Frozen bronchial biopsies from 12 normal and 18 asthmatic individuals were double stained with EBM 11 ( a CD 68 macrophage marker ) and either a rabbit anti IL 1beta or a rabbit anti IL 1ra . ^^^ There was an increased expression of both IL 1beta and IL 1ra in the asthmatic bronchial epithelium , p < 0 . 0002 and p < 0 . 0001 , respectively . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The effect of hypoxia ischemia ( HI ) on IL 1 , and IL 6 bioactivity in relation to expression of IL 1 alpha , IL 1 beta , and IL 6 mRNA was studied , and the neuroprotective efficacy of IL 1 receptor antagonist ( IL 1ra ) was evaluated in neonatal rats . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RESULTS : Stem cell factor and IL 11 were detected in all reproductive tract fluids examined whereas large amounts of IL 1 beta and IL 1RA was found in AF and hOF . ^^^ HOF contained IL 2 , IL 6 , IL 8 , TNF alpha , MIP 1 alpha , IFN gamma , and high levels of IL 1 beta , IL 10 , IL 1RA , and sIL 2R . ^^^ Amniotic fluid contained sIL 2R , IL 8 , IL 1 beta , IL 1RA , IL 6 , TNF alpha , and MIP 1 alpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : Interleukin 1 receptor antagonist ( IL 1ra ) , soluble tumor necrosis factor receptors p 55 and p 75 ( sTNFr ; p 55 and p 75 ) , interleukin 1 beta ( IL 1 beta ) , tumor necrosis factor alpha ( TNF alpha ) , interleukin 8 ( IL 8 ) , and monocyte chemoattractant protein 1 ( MCP 1 ) were assessed by immunoassays in sera and MNC culture supernatants of 27 patients with RA with active disease before and 14 patients with inactive disease during MTX treatment , and 10 healthy controls . ^^^ At the cellular level , resting MNC of patients with active RA released more IL 1 beta and IL 8 , but less IL 1ra , and showed a lower ratio of IL 1ra : IL 1 beta than MNC of patients without inflammatory symptoms or healthy controls . ^^^ CONCLUSION : Circulating levels of IL 1ra and sTNFr as well as IL 1 beta , IL 8 , and sTNFr p 75 release from MNC and the ratio of IL 1ra : IL 1 beta production by these cells serve as markers to assess complete disease remission in patients with RA during MTX treatment . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Induced gene transcription within 2 h was associated with the release of cytokines such as tumour necrosis factor ( TNF ) , interleukin 1 beta ( IL 1 beta ) , IL 6 , IL 8 , and also the anti inflammatory mediator IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The most direct evidence that IL 1 beta contributes to ischemic injury , however , is the demonstration that infarct volume in focal ischemia is reduced following intraventricular injection of an endogenous interleukin 1 receptor antagonist ( IL 1ra ) , or after IL 1ra is overexpressed in brain using an adenoviral vector to transfer IL 1ra cDNA to brain cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 beta ( 15 micrograms / kg ) in combination with either IL 1ra ( 100 mg / kg ) or IL 1ra vehicle i . p . on the same schedule demonstrated a significant CA 1 neuroprotection that could be nullified by IL 1ra : IL 1 beta + IL 1ra vehicle , 153 + / 16 / mm ; and IL 1 beta + IL 1ra , 67 + / 36 / mm . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To determine whether such conditions might alter the balance of epidermal keratinocyte IL 1 and the IL 1 receptor antagonist ( IL 1ra ) , TNF alpha and TGF beta 1 were added to HaCaT cells , a human adult keratinocyte cell line . mRNA levels of IL 1 alpha , IL 1 beta , and IL 1Ra were detected by polymerase chain reaction ( PCR ) on reverse transcribed RNA extracts , followed by Southern blot of the PCR products , 35S labeled probe hybridization , and quantification against standard curves . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We examined the participation of endogenous IL 1ra in the production of IL 1 beta in vitro . ^^^ Macrophages cultured on adherent IgG produced a 100 fold molar excess of IL 1ra , compared with IL 1 beta . ^^^ In the presence of a neutralizing monoclonal antibody ( mAb ) against rabbit IL 1ra , the production of antigenic IL 1 beta increased by 20 60 % . ^^^ The administration of anti IL 1ra mAb with LPS into rabbit knee joints increased the IL 1 activity 4 fold and the production of antigenic IL 1 beta by 30 50 % . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present study , we quantified IL 1 beta , IL 1 receptor antagonist ( IL 1Ra ) , IL 6 and TNF alpha protein levels in the supernatant of long term cultures generated from BM cells of FA patients . ^^^ IL 1 beta , IL 1Ra , TNF alpha and IL 6 protein secretion was assessed using immunoassays . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We investigated whether psychotropics orally administered to rats affect levels of interleukin 1 beta ( IL 1 beta ) and interleukin 1 receptor antagonist ( IL 1Ra ) mRNA in the hypothalamus , hippocampus , frontal cortex , and brain stem , using a reverse transcription polymerase chain reaction method . ^^^ The increase in IL 1Ra mRNA was 6 112 times larger than that of IL 1 beta mRNA in most brain regions examined . ^^^ These results suggest that chronic treatment with psychotropics causes greater amplifying effects on IL 1Ra mRNA than IL 1 beta mRNA in the brain . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Mice injected with LPS ( 10 mu g / mouse , sc ) or saline were submitted to a 15 min restraint stress and sacrificed 1 or 2 h later to assess the effect of stress on the induction of interleukin 1beta ( IL 1beta ) and other proinflammatory cytokines ( IL 1alpha , IL 1ra , IL 6 , and tumor necrosis factor alpha ) in the spleen , pituitary , hypothalamus , hippocampus , and striatum . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Concentrations and ex vivo production of interleukin 1beta ( IL 1beta ) , tumour necrosis factor alpha ( TNF ) , interleukin 6 ( IL 6 ) , interleukin 1 receptor antagonist ( IL 1RA ) and TNF soluble receptors were followed in bronchoalveolar lavage ( BAL ) fluid and blood from 10 HIV seronegative patients with Pneumocystis carinii pneumonia ( PCP ) and compared with values found in healthy volunteers . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Hormonal regulation of serum and endometrial IL 1 alpha , IL 1 beta and IL 1ra : IL 1 endometrial microenvironment of the human embryo at the apposition phase under physiological and supraphysiological steroid level conditions . ^^^ We have investigated serum and intracavitary levels of IL 1 alpha , IL 1 beta and IL 1ra from agonadal women undergoing mock cycles ( n = 20 ) of oocyte donation as a clinical model of controlled hormonal stimulation . ^^^ Further , we compared the intracavitary IL 1 alpha , IL 1 beta and IL 1ra levels in the microenvironment of the human embryo at the apposition phase , day 5 after progesterone ( P ) administration using two different clinical models : oocyte donation ( n = 20 ) which provides physiological steroid levels and a higher implantation rate per embryo , and in vitro fertilization ( n = 6 ) with supraphysiological hormonal levels and a lower implantation rate . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 receptor type 1 ( IL 1RI ) , IL 1 receptor antagonist ( IL 1Ra ) , and IL 1 beta mRNAs were determined by sensitive RNase protection assays in brain target regions for IL 1 beta ( cerebellum , parieto frontal cortex , hippocampus , and midbrain ) . ^^^ The results show that chronic icy microinfusion of IL 1 beta induced significant anorexia , increased the cerebellar IL 1RI mRNA content , increased IL 1Ra and IL 1 beta mRNAs levels in the cerebellum > midbrain > cortex > hippocampus , and induced profiles of IL 1RI mRNA , IL 1Ra mRNA , and IL 1 beta mRNA that were highly intercorrelated . ^^^ On the other hand , levels of rat glyceraldehyde 3 phosphate dehydrogenase mRNA and 18S rRNA were fairly constant , and heat inactivated IL 1 beta had no effect on food intake or on IL 1RI , IL 1Ra , and IL 1 beta mRNAs levels in any brain region . ^^^ The data suggest the operation of an IL 1 beta feedback system ( IL 1 beta / IL 1Ra / IL 1RI ) in brain regions . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Serum levels of IL 1Ra , IL 1 beta , IL 6 , tumour necrosis factor ( TNF alpha , TNF soluble receptors ( TNF sR ) and IL 2sR were measured by enzyme linked immunosorbent assay . ^^^ IL 1Ra levels correlated with IL 1 beta ( P < 0 . 005 ) , IL 6 ( P < 0 . 0001 ) and TNF sR 55 ( P < 0 . 0001 ) levels , but not with those of TNF alpha , TNF sR 75 , IL 2sR , neopterin or IgA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Addition of IL 1ra blocked IL 1 beta induced changes in C 6 cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta , IL 6 , and IL 1ra concentrations were higher in patients with infections , neoplasms , and NIID than in healthy controls . ^^^ The ex vivo production of IL 1beta and IL 1ra in all patients with FUO did not differ from that in controls ; however , production of TNF alpha was lower in patients with neoplasms and NIID , and IL 6 production was lower in patients with neoplasms . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Here we show that the CNS responds to systemic inflammation with pronounced IL 1beta gene expression and limited IL 1 receptor antagonist ( IL 1ra ) , IL 10 , and IL 13 gene expression . ^^^ In contrast , in the anterior pituitary , we found limited IL 1beta gene expression but marked induction of the mRNA encoding for the secreted isoform of IL 1ra , secreted IL 1ra . ^^^ The CNS transcription of the HIV 1 replication factor IL 1beta in the context of limited transcription of the IL 1 replication inhibitors IL 1ra , IL 10 , and IL 13 might help explain the negative impact of systemic inflammation on the clinical course of AIDS . ^^^ In addition , we propose that IL 1ra may be secreted by the anterior pituitary as a systemic anti inflammatory hormone that is released in response to IL 1beta originated from multiple sources . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1ra , IL 6 , and IL 1 beta were correlated best with the collagenase activity in the SF ( r = 0 . 63 ; 0 . 57 ; 0 . 55 ; Spearman ' s rank correlation ) , while IL 1 beta ( r = 0 . 53 ) and IL 1ra ( r = 0 . 52 ) were best correlated with the caseinase activity in the samples . ^^^ The SF concentration of IL 1ra was well correlated with the levels of IL 6 , IL 1 beta , 2 8 , and TNF alpha ( r from 0 . 73 to 0 . 66 ; all p < 0 . 005 ) , but not with IL 1 alpha . ^^^ IL 1 beta and IL 1ra in the SF were positively correlated with the erythrocyte sedimentation rate ( ESR ) . ^^^ CONCLUSIONS : The determination of IL 1 beta and IL 1ra in the SF of patients with joint disorders as examined in this study seems to allow to a certain extent a prediction of the collagenase and caseinase activity contained in the diseased joint . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
BAL and plasma was assayed for interleukin 1 beta ( IL 1 beta ) , tumour necrosis factor alpha ( TNF alpha ) , IL 8 , IL 10 , interleukin 1 receptor antagonist ( IL 1ra ) and the TNF soluble receptors ( TNFsrs ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Reverse transcriptase polymerase chain reaction ( RT PCR ) was performed for IL 1 alpha , IL 1 beta and IL 1 receptor type 1 ( IL 1R ) on mRNA isolated from mouse preimplantation embryos and uteri collected between the 2 cell to blastocyst stage . ^^^ Our findings suggest that there is a potential embryonic maternal IL 1 signaling mechanism through the expression of IL 1 beta by the preimplantation embryo and the expression of IL 1R in the uterus . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Saturable transport systems from blood to the CNS have been described for interleukin ( IL ) 1 alpha , IL 1 beta , IL 1 receptor antagonist ( IL 1ra ) , IL 6 , and tumor necrosis factor alpha ( TNF alpha ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Plasma and cellular levels of IL 1ra and IL 1 beta were also measured . ^^^ Plasma concentrations of IL 1 beta and IL 1ra were elevated in haemodialysis patients and undetectable in controls . ^^^ Whereas plasma IL 1 beta decreased throughout haemodialysis , IL 1ra further increased , with no significant differences between the two membranes used . ^^^ Total cellular IL 1 beta and IL 1ra were also higher in the patient group than in the healthy controls . ^^^ A further increase of both IL 1 beta and IL 1ra was detected at the end of the haemodialysis session with any membrane . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : Circulating levels of cytokines inducing the production of acute phase proteins such as interleukin ( IL ) 6 , IL 1 beta , and tumor necrosis factor ( TNF ) alpha , and of cytokine inhibitors such as TNF soluble receptors ( TNF sR 55 and TNF sR 75 ) and IL 1 receptor antagonist ( IL 1ra ) , were measured in 2 cohorts of patients . ^^^ Serum levels of IL 6 were measured using a biological assay , and concentrations of IL 1 beta , TNF alpha , TNF sR 55 , TNF sR 75 , and IL 1ra were assessed by immunoassays . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In a subset of 20 patients , production of interleukin 1 alpha ( IL 1 alpha ) , interleukin 1 beta ( IL 1 beta ) , tumor necrosis factor alpha ( TNF alpha ) , and IL 1 receptor antagonist ( IL 1ra ) at the mRNA and protein levels was determined using in situ hybridization with biotin labeled ribo probes and immunohistochemistry . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
CONCLUSIONS : Differential expression of IL 1 beta , IL 1ra , IL 1RI , and IL 1RII mRNAs after focal stroke may suggest a distinct role ( s ) for each component of the IL 1 system in ischemic injury . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We investigated the expression of interleukin 1 receptors ( IL 1R ) on the surfaces of cultured gingival fibroblasts derived from healthy and inflamed gingiva and the effects of IL 1 alpha and IL 1 beta and prostaglandin E 2 ( PGE 2 ) on IL 1R expression . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To assess the possible influence of endogenous glucocorticoids on cytokine expression in the brain , adrenalectomized mice and sham operated mice were injected with saline or lipopolysaccharide ( LPS , 10 micrograms / mouse , subcutaneously ) and the levels of transcripts for IL 1 alpha , IL 1 beta , IL 1ra , IL 6 and tumor necrosis factor alpha ( TNF alpha ) were determined 2 h after treatment in the spleen , pituitary , hypothalamus , hippocampus and striatum , using semi quantitative reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The mRNA expression of tumour necrosis factor alpha , interleukin 1 alpha ( IL 1 alpha ) , IL 1 beta , IL 1 receptor antagonist ( IL 1ra ) , IL 4 , IL 8 , IL 10 , IL 12 , granulocyte macrophage colony stimulating factor , transforming growth factor beta , interferon gamma and amphiregulin were assayed in cutaneous warts and normal skin by semiquantitative reverse transcriptase polymerase chain reaction . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
These data indicate that activated Th 1 and Th 2 cells express different molecules on the cell surface able to induce distinct pro inflammatory ( IL 1beta ) or anti inflammatory ( IL 1Ra ) responses in monocytes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Because cytokines and their antagonists are significant factors in these host responses , the present research on aged subjects was designed to investigate plasma concentrations of the cytokines interleukin 1 beta ( IL 1 beta ) and tumor necrosis factor alpha ( TNF alpha ) and those of their antagonists IL 1 receptor antagonist ( IL 1ra ) and soluble TNF receptor ( sTNFr ) . ^^^ Plasma IL 1 beta , TNF alpha , IL 1ra , sTNFr ( 55 kDa ) , and neopterin were measured using enzyme linked immunosorbent assay techniques . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Three naturally occurring ligands for the IL 1 receptor ( IL1R ) exist : the agonists IL 1alpha and IL 1beta and the IL 1 receptor antagonist IL1RA ( ref . 2 ) . ^^^ A region that is important for biological function in IL 1beta , the ' receptor trigger site ' is not in direct contact with the receptor in the IL1RA complex . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In this study , we investigated the regulation of the IL 1 beta system ( IL 1 beta , IL 1 receptor type 1 ( IL 1RI ) and IL 1 receptor antagonist ( IL 1Ra ) ) in the central nervous system ( CNS ) in response to the chronic intracerebroventricular ( i . c . v . ) microinfusion ( via osmotic minipumps ) of 8 ng IL 1 beta / 24 h / 72 h a dose that yields estimated pathophysiological concentrations in the CSF . ^^^ IL 1 beta , IL 1RI and IL 1Ra mRNAs were determined by sensitive RNase protection assays in brain target regions for IL 1 beta ( cerebellum , parieto frontal cortex , hippocampus , hypothalamus and midbrain ) . ^^^ The results show that chronic i . c . v . microinfusion of IL 1 beta increased the IL 1 beta mRNA , IL 1R1 mRNA and IL 1Ra mRNA levels in the hypothalamus > cerebellum in both obese ( fa / fa ) and lean ( Fa / Fa ) Zucker rats . ^^^ The profiles of IL 1 beta mRNA , IL 1RI mRNA and IL 1Ra mRNA in the same hypothalamic samples obtained from obese or lean rats were highly intercorrelated . ^^^ On the other hand , levels of rat glyceraldehyde 3 phosphate dehydrogenase mRNA were fairly constant , and heat inactivated IL 1 beta ( 8 ng / 24 h / 72 h ) had no effect on IL 1 beta , IL 1RI and IL 1Ra mRNAs levels in any brain region . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The combination of endotoxin and dexamethasone induces type 2 interleukin 1 receptor ( IL 1r 2 ) in monocytes : a comparison to interleukin 1 beta ( IL 1 beta ) and interleukin 1 receptor antagonist ( IL 1ra ) . ^^^ Soluble type 2 interleukin 1 receptor ( IL 1r 2 ) and interleukin 1 receptor antagonist ( IL 1ra ) regulate inflammation by competitively inhibiting the binding of IL 1 beta to the signalling IL 1 receptor . ^^^ Therefore , LPS and dexamethasone synergism in IL 1r 2 induction may be important in controlling IL 1 beta effects . ^^^ Although IL 1r 2 and IL 1ra may work together to suppress IL 1 beta effects in sepsis , inflammatory cells differentially regulate these cytokines . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The mRNA levels of the secreted IL 1ra isoform , but not intracellular IL 1raI and 2 , and IL 1RII were elevated in PP EC and paralleled those of IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin ( IL ) 1 is a potent inducer of bone resorption , and an increased secretion of the IL 1 agonists IL 1 alpha and IL 1 beta relative to the IL 1 receptor antagonist ( IL 1ra ) has been proposed as a mechanism leading to post menopausal osteoporosis . ^^^ In spite of a significant bone maintaining effect of ERT , the basal and LPS stimulated secretion of IL 1 alpha , IL 1 beta , and IL 1ra was identical in the two groups . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We demonstrated the presence of intracellular IL 1 alpha , IL 1 beta , IL 1ra , and TNF alpha in circulating CD14+ monocytes from HIV infected patients . ^^^ In vivo intracellular cytokine production of IL 1 alpha , IL 1 beta , IL 1ra , and TNF alpha was higher in monocytes from HIV infected individuals compared to monocytes from healthy controls ; however , only the data concerning IL 1 alpha reached statistical significance . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
These , as well as some antiinflammatory cytokines , eg , IL 1 receptor antagonist ( IL 1ra ) , IL 10 , and transforming growth factor beta 1 ( TGF beta 1 ) , were analyzed in serum ( IL 6 , IL 1ra , IL 10 , TGF beta 1 ) and stimulated blood monocytes ( IL 1 beta , TNF alpha , IL 6 ) obtained from elderly patients with protein energy malnutrition ( PEM ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Normal and immortalized keratinocytes constitutively produced and released IL 1 alpha , IL 1 beta and IL 1 receptor antagonist ( IL 1RA ) but IL 1 synthesis by NHK was significantly higher than by cell lines . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Here , we investigated the regulation of the IL 1 beta system [ IL 1 beta , IL 1 receptor type 1 ( IL 1RI ) , IL 1 receptor antagonist ( IL 1Ra ) , IL 1 receptor accessory proteins ( IL 1R AcP 1 and 2 ) ] , TNF alpha , TGF alpha , and TGF beta 1 mRNAs in the hypothalamus of Wistar rats in response to the chronic intracerebroventricular ( ICV ) microinfusion ( via osmotic minipumps ) of HIV 1 gp 120 ( 100 , 500 , and 1000 ng / 24 h for 72 h ) . ^^^ Gp 120 increased IL 1 beta , IL 1Ra , TNF alpha , and TGF beta 1 mRNAs . ^^^ The data suggest potential cytokine cytokine interactions with positive ( IL 1 beta < > TNF alpha ) and negative ( IL 1Ra > IL 1 beta ; TGF beta 1 > IL 1 beta / TNF alpha ) feedback in gp 120 action . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The aims of this study were to determine whether the key pro inflammatory cytokines interleukin 1 beta ( IL 1 beta ) and IL 6 could affect the growth of Actinobacillus actinomycetemcomitans or Porphyromonas gingivalis and to determine whether these organisms could hydrolyse IL 1 beta , IL 6 or the anti inflammatory IL 1 receptor antagonist ( IL 1ra ) . ^^^ IL 1 beta , IL 6 or IL 1ra were added to culture supernatants and incubated for up to 24 h . ^^^ Supernatants from P . gingivalis cultures , but not those from A . actinomycetemcomitans , hydrolysed IL 1 beta , IL 6 and IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
A series of mutants of human IL 1 receptor antagonist ( IL 1ra ) has been designed by comparison of IL 1ra and IL 1beta structures in order to increase receptor antagonist capacity . ^^^ Upon in vitro and in vivo assay of IL 1 antagonism , the IL 1ra mutants DoB 0039 ( N 91 > R ) , DoB 0040 ( T 109 > A ) and DoB 0041 ( N91 / T109 > R / A ) could inhibit IL 1beta effects more efficiently than wild type IL 1ra , with DoB 0041 being the most active . ^^^ Analysis of the receptor binding capacity of the IL 1ra mutants showed that all three mutants could inhibit binding of IL 1alpha or IL 1beta to IL 1RI bearing cells more efficiently than wild type IL 1ra . ^^^ Conversely , binding of IL 1beta to IL 1RII bearing cells could be inhibited by DoB 0041 much less efficiently than by wild type IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Here we review our studies on IL 1 beta and IL 1ra mRNA levels in the pituitary in a rat model of SIRS . ^^^ IL 1ra mRNA levels peaked at 6 h post LPS administration , later than those of IL 1 beta mRNA . ^^^ IL 1ra gene expression is profoundly induced in the pituitary in vivo during systemic inflammation and its induction follows that of IL 1 beta , but it is differentially regulated and tissue specific , occurring predominantly in the anterior pituitary . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
As the adenylate cyclase is presumably not activated , we have in the present study investigated whether the cGMP pathway was involved in the actions of IL 1beta , whether the effects of IL 1beta on cultured human thyrocytes were reversible , and whether the effects were counteracted by IL 1 receptor antagonist ( IL 1ra ) , a naturally occurring , specific blocker of IL 1 receptors on many cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We analyzed two distinct phenotypes of Schwann cells ( SC ) , non differentiated and differentiated , for their ability to produce IL 1alpha and IL 1beta , and to express message for IL 1 receptor antagonist ( IL IRA ) and IL 1R type 1 , in vitro . ^^^ Inducible expression of genes for IL 1alpha , IL 1beta , IL 1RA and IL 1R type 1 in both differentiated and non differentiated SC suggest autocrine and paracrine regulation of IL 1 by SC . . ^^^ SC constitutively expressed low levels of message for IL 1alpha and IL 1beta but not IL 1RA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
When incubated with IL 1beta , IL 1RA inhibited the IL 1beta enhanced PLA 2 activity . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The cellular content of fresh cells and the production of IL 1 beta and IL 1Ra with and without lipopolysaccharide ( LPS ) stimulation of the cells were evaluated and measured by enzyme linked immunosorbent assay ( ELISA ) . ^^^ Because IL 1 beta and IL 1Ra levels 15 min after starting dialysis using bioincompatible dialysis membranes were reduced from the levels at 0 min , the findings suggest that measurement of cytokines ' during dialysis treatment at an early stage is a useful marker for evaluating the biocompatibility of a dialysis membrane . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : We performed indirect immunohistochemistry studies of muscle tissue sections with a panel of 16 different cytokine specific monoclonal antibodies , directed against interleukin 1alpha , ( IL 1alpha ) , IL 1beta , IL 1 receptor antagonist ( IL 1Ra ) , IL 2 , IL 3 , IL 4 , IL 6 , IL 8 , IL 10 , IL 13 , interferon gamma ( IFN gamma ) , tumor necrosis factor alpha ( TNF alpha ) , granulocyte macrophage colony stimulating factor ( GM CSF ) , transforming growth factor beta 1 ( TGF beta 1 ) , TGF beta 2 , and TGF beta 3 in 5 untreated patients each with PM , DM , and IBM and in 4 normal controls . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The impact of continuous hemofiltration ( CHF ) using a polyacrylonitrile membrane on the kinetics of tumor necrosis factor alpha ( TNF alpha ) , interleukin 1 beta ( IL 1 beta ) , and their inhibitors ( soluble TNF receptors [ sTNFrI , sTNFrII ] , interleukin 1 receptor antagonist [ IL 1Ra ] ) was assessed in nine oliguric patients suffering from systemic inflammatory response syndrome . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The interleukin 1 ( IL 1 ) family is a group of related cytokines including two agonist proteins ( IL 1alpha and IL 1beta ) , each derived by enzymatic cleavage of precursor proteins ( pro IL 1alpha and pro IL 1beta ) , and three forms of an antagonist protein ( IL 1ra , icIL 1raI , icIL 1raII ) . ^^^ Information on this line has been provided by several groups mainly with studies of mutagenesis of IL 1alpha , IL 1beta and IL 1ra in parallel with biological assays of activity . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 receptor antagonist ( IL 1Ra ) , IL 1 beta and TNF alpha in the culture medium supernatants were measured using the ELISA method . ^^^ Furthermore , IL 1Ra , IL 1 beta and TNF alpha production by PBMC increased in accordance with the concentrations of MDP . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Intra cytoplasmic TNF alpha and IL 1beta were detected at lower frequency , and < 1 % of CD34+ cells expressed IL 1ra or IL 6 , whereas IL 1alpha , IL 10 and G CSF were not detected . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Secretion of IL 1 beta , TNF alpha , IL 8 and IL 1ra by human polymorphonuclear leukocytes in response to lipopolysaccharides from periodontopathic bacteria . ^^^ We therefore investigated the amounts of the cytokines interleukin 1 beta ( IL 1 beta ) , tumor necrosis factor alpha ( TNF alpha ) , IL 8 and IL 1 receptor antagonist ( IL 1ra ) secreted by PMN from healthy donors following stimulation with lipopolysaccharide ( LPS ) from 4 periodontopathic bacteria , Porphyromonas gingivalis , Actinobacillus actinomycetemcomitans , Capnocytophaga ochracea and Fusobacterium nucleatum , and the non oral bacterium Escherichia coli . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To study the role of central IL 1 receptors in the effects of recombinant human IL 1 beta ( IL 1 beta ) on behavior and body weight , intracerebroventricular ( i . c . v . ) injection of the specific antagonist of IL 1 receptors , IL 1ra , was administered to mice injected intraperitoneally ( i . p . ) and i . c . v . with various doses of IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The values of plasma interleukin 1alpha ( IL 1alpha ) , interleukin 1beta ( IL 1beta ) and interleukin 1 receptor antagonist ( IL 1ra ) levels were evaluated as the markers of pre eclampsia in 35 serial plasma samples from ten pregnant women who subsequently developed pre eclampsia and in 74 plasma samples from 20 uncomplicated pregnancies , retrospectively . ^^^ No correlation was found between plasma IL 1alpha , IL 1beta and IL 1ra levels , liver and renal function tests , thrombocyte and white blood cell counts , proteinuria , systolic and diastolic blood pressures and gestational weeks . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The functional integrity of AM was determined by their ability to produce interleukin 1 beta ( IL 1 beta ) and interleukin 1 receptor antagonist ( IL 1ra ) before and after platinum containing systemic chemotherapy . ^^^ The productions of IL 1 beta and IL 1ra were quantitated by enzyme immunoassays . ^^^ No significant difference in spontaneous and lipopolysaccharide ( LPS ) stimulated IL 1 beta or IL 1ra production by AM was observed between lung cancer patients and control patients . ^^^ Significant increase of IL 1 beta and significant decrease of IL 1ra production by AM were demonstrated in patients with small cell lung cancer who experienced response to systemic chemotherapy . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Maximum levels of TNF alpha and IL 8 were detected at 2 hours after LPS injection , whereas IL 1 beta and IL 1 receptor antagonist ( IL 1Ra ) were detected at 6 and 9 hours , respectively . ^^^ These results provide new evidence that IL 8 as well as TNF alpha are the most proximal cytokines and induce subsequent production of IL 1 beta and IL 1Ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The present study was carried out to test the hypotheses that ( 1 ) cellular secretion of interleukin 1 beta ( IL 1 beta ) , interleukin 1 receptor antagonist ( IL 1Ra ) , and soluble interleukin 1 receptor type 2 ( IL 1sRII ) is abnormal in female CFS patients compared to age and activity matched controls ; ( 2 ) that these abnormalities may be evident only at certain times in the menstrual cycle ; and ( 3 ) that physical exertion ( stepping up and down on a platform for 15 min ) may accentuate differences between these groups . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Moreover , the spontaneous IL 1Ra / IL 1beta production ratio in CRF ( 140 + / 16 , p < 0 . 01 ) and in HD ( 142 + / 19 , p < 0 . 01 ) was significantly lower than that of the controls ( 294 + / 41 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Upregulation of both interleukin 1 beta ( IL 1 beta ) and its naturally occurring receptor antagonist , interleukin 1 receptor antagonist ( IL 1ra ) , has previously been observed on asthmatic bronchial epithelium compared with normal airways . ^^^ METHODS : The effect of inhaled beclomethasone dipropionate ( BDP ) on asthmatic bronchial epithelial expression of IL 1 beta and IL 1ra was studied . ^^^ Frozen bronchial biopsy specimens from nine asthmatic subjects receiving 1000 micrograms BDP daily for eight weeks and from six asthmatic subjects receiving matching placebo were stained with anti IL 1 beta and anti IL 1ra antibodies . ^^^ RESULTS : There was a significant twofold decrease in the epithelial expression of IL 1 beta after treatment with BDP but no significant change was seen in IL 1ra ( P = 0 . 175 ) . ^^^ CONCLUSION : The selective inhibition of IL 1 beta , without effect on IL 1ra , provides a novel mechanism for the anti inflammatory action of glucocorticosteroids . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Among the serum cytokines mainly produced by monocytes / macrophages interleukin ( IL ) 8 levels were decreased in steroid sensitive patients vs controls , with normal levels observed for IL 1 alpha , IL 1 beta , IL 1RA and tumor necrosis factor ( TNF alpha ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1Ra was present in the supernatants of both cells , with production significantly enhanced by IL 1beta , and by the combination of IL 1beta and IL 6 . ^^^ To examine whether IL1Ra is produced by liver cells with characteristics resembling an acute phase protein , human primary hepatocytes isolated from liver biopsies and HepG 2 hepatoma cells were stimulated with IL 1beta , IL 6 , and TNFalpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Imbalance between IL 1ra and IL 1 beta was expressed as a molar ratio of IL 1ra / IL 1 beta protein : ( Sar ; 4 . 20 + / 2 . 06 , IPF ; 4 . 26 + / 3 . 41 , HS ; 3 . 44 + / 3 . 09 versus NS 8 . 33 + / 2 . 77 : P < 0 . 001 ) . ^^^ In conclusion , the imbalance of IL 1 beta and IL 1ra production was confirmed at three levels : biological activity , amounts of protein , and gene transcript obtained from BALF macrophages in chronic inflammatory processes in the lungs . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The in vitro production of interleukin 1beta ( IL 1beta ) , IL 6 , and the IL 1 receptor antagonist ( IL 1ra ) in whole blood upon stimulation with different bacterial strains was measured to study the possible relationship between disease severity and the cytokine inducing capacities of these strains . ^^^ Escherichia coli , Neisseria meningitidis , Neisseria gonorrhoeae , Bacteroides fragilis , Capnocytophaga canimorsus , Staphylococcus aureus , Enterococcus faecalis , Streptococcus pneumoniae , and Streptococcus pyogenes induced the cytokines IL 1beta , IL 6 , and IL 1ra . ^^^ E . coli treated with cefuroxime and gentamicin induced higher levels of IL 1beta and IL 6 production but levels of IL 1ra production similar to that of heat killed E . coli . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
However , IL 1ra treatment had no effect on glomerular IL 1 beta mRNA expression and caused only a small reduction in the high levels of glomerular expression of platelet derived growth factor beta protein ( decreases 6 % ; P < 0 . 05 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The cytokine protein content ( IL 1 beta , IL 3 , IL 4 , IL 5 , IL 6 , IL 8 , IL 10 , tumor necrosis factor alpha , granulocyte macrophage colony stimulating factor , IL 1RA , RANTES , GRO alpha ) of tissue homogenates was measured by ELISA . ^^^ IL 6 , IL 8 , IL 10 , tumor necrosis factor alpha , GRO alpha , and RANTES were detected in all specimens , without significant differences between groups ( p > or = 0 . 05 ) , whereas significnatly higher concentrations of IL 1 beta and IL 1RA were found in turbinate mucosa ( p < or = 0 . 05 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We have evaluated the course of IL 1 alpha , IL 1 beta , and soluble IL 1RA ( sIL 1RA ) serum levels in smokers and nonsmokers with GO undergoing orbital radiotherapy ( OR ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1 receptor antagonist ( IL 1ra ) , administered acutely into the lesion , produced a significantly decreased optical density of IL 1beta ir at the LDA at P 0 compared to animals that received injections of vehicle , human recombinant IL 1beta , or a combination injection of IL 1ra + IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To investigate the involvement of the IL 1 system we determined serum levels of IL 1beta , IL 1Ra and sIL 1RII in 90 HIV patients . ^^^ While IL 1Ra concentrations increased significantly with progressive CDC disease stages , sIL 1RII and IL 1beta were not altered in our cohort . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The aim of this study was to analyze the IL 1beta and IL 1ra gene polymorphism and linkage disequilibrium coefficient between the different alleles of these genes in patients with Crohn ' s disease ( CD ) or ulcerative colitis ( UC ) , according to the severity of the disease . ^^^ The IL 1beta and IL 1ra gene polymorphism was studied after specific amplification of variable regions by PCR . ^^^ A penta allelic polymorphism , corresponding to a VNTR region located in intron 2 of the IL 1ra gene , was analyzed , whereas bi allelic RFLPs displayed by two restriction enzymes ( TaqI and AvaI ) at position 511 of the IL 1beta gene were analyzed . ^^^ Furthermore , simultaneous analysis of the IL 1beta and IL 1ra genes that are located in the same region of chromosome 2 revealed that CD patients carrying the IL 1beta allele 2 were more often noncarriers of IL 1ra allele 2 ( p < 0 . 005 ) . ^^^ Moreover , UC and CD patients were , characterized by a lower frequency of the association of IL 1ra allele 2 and IL 1beta allele 2 compared with controls ( 8 . 3 vs 20 . 3 % and 10 . 6 vs 20 . 3 % , p < 0 . 03 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To test for IL 1 beta binding whole vagus ( abdominal , laryngeal , and thoracic ) and sections of hepatic vagus and liver hilus were incubated with biotinylated IL1ra and processed for avidin biotin complex ( ABC ) or avidin FITC histochemistry . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
This study demonstrates that direct contact with stimulated T cells favours the production of IL 1beta over that of IL 1 receptor antagonist ( IL 1Ra ) in both peripheral blood monocytes and the monocytic cell line THP 1 . ^^^ Differentiation of THP 1 cells with 1 , 25 ( OH ) 2D3 did not affect the balance between IL 1beta and IL 1Ra production , enhancing both cytokines 2 . 3 and 1 . 6 fold , respectively . ^^^ Among different inhibitors of phosphorylation and dephosphorylation processes , only okadaic acid , an inhibitor of serine / threonine phosphatases , differentially modulates the production of IL 1beta and IL 1Ra . ^^^ Indeed , okadaic acid upregulated IL 1beta and decreased IL 1Ra at the mRNA and protein level in monocytic cells activated by membranes of stimulated T cells . ^^^ These results suggest that serine / threonine phosphatases play a part in the differential regulation of the production of IL 1beta and IL 1Ra by monocytes upon direct cell cell contact with stimulated T cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Plasma IL 1Ra peaked shortly after IL 1beta and decreased steeply in 1 to 2 days , followed by sustained moderately elevated levels in shock patients . ^^^ A second interesting observation was that , unlike the pattern in plasma , IL 1sRII levels in CSF paralleled those of IL 1beta and IL 1Ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The action of interleukin 1 beta ( IL 1 beta ) and its receptor antagonist IL 1ra were investigated on dual component , isolated AMPA and NMDA field excitatory post synaptic potentials ( EPSP ) and on the induction and maintenance of long term potentiation in the rat dentate gyrus in vitro . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To evaluate the role of residual IL 1 alpha production in IL 1 beta / mice , we used IL 1 receptor antagonist ( IL 1ra ) . ^^^ In IL 1 beta + / + mice , IL 1ra inhibited production of IL 6 after zymosan , without affecting TNF alpha synthesis . ^^^ There was no further inhibitory effect of IL 1ra on IL 6 production in IL 1 beta / mice , suggesting no role for IL 1 alpha in zymosan induced IL 6 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : SF levels of interleukin 1alpha ( IL 1alpha ) , IL 1beta , IL 1 receptor antagonist ( IL 1Ra ) IL 11 , tumor necrosis factor alpha ( TNF alpha ) , soluble TNF receptor 1 ( sTNFR 1 ) , leukemia inhibitory factor ( LIF ) , all measured by immunoassays , and of IL 6 , measured with a bioassay using B 9 cells , were evaluated in 11 patients with systemic JRA , 24 with pauciarticular JRA , and 22 adult patients with RA . ^^^ We found no significant differences in SF levels of IL 1beta , IL 1Ra , TNF alpha , sTNFR 1 , or LIF . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Culture supernatants and cell lysates were analyzed by ELISA for IL 1 beta , IL 3 , IL 4 , IL 5 , IL 6 , IL 8 , IL 11 , IL 1 receptor antagonist ( IL 1ra ) , tumor necrosis factor alpha ( TNF alpha ) , and granulocyte macrophage colony stimulating factor ( GM CSF ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Plasma concentrations of IL 1 beta , IL 6 , TNF , IL 1 receptor antagonist ( IL 1RA ) and soluble TNF receptors ( sTNFRs ) type 1 and type 2 were determined twice before rIFN alpha treatment ( on day 11 and day 1 ) , and on days 11 , 32 and 120 of treatment . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Here , we investigated the regulation of the IL 1beta system [ IL 1beta , IL 1 receptor type 1 ( IL 1RI ) , IL 1 receptor antagonist ( IL 1Ra ) ] , TNF alpha and TGF alpha mRNAs in the rat central nervous system ( CNS ) in response to the constant intracerebroventricular ( ICV ) microinfusion of HIV 1 gp 120 for 72 h and 144 h . ^^^ The results show that gp 120 : ( 1 ) increased IL 1beta and IL 1Ra mRNAs levels in the same samples from the cerebellum , hypothalamus and midbrain , with the largest increase in the hypothalamus ; ( 2 ) induced profiles of IL 1beta mRNA and IL 1Ra mRNA that were highly intercorrelated ; ( 3 ) increased the hypothalamic TNF alpha mRNA levels ; and ( 4 ) did not affect the IL 1RI mRNA and TGF alpha mRNA levels in any brain region . ^^^ A dysregulation in the IL 1beta / IL 1Ra CNS balance and a mutual induction and synergistic activity of IL 1beta and TNF alpha could result in a deleterious amplification cycle of cellular activation and cytotoxicity with implications to HIV 1 associated encephalitis , encephalopathy , and neurological manifestations . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
A leukotriene biosynthesis inhibitor ( MK 886 ) , a platelet activating factor ( PAF ) receptor antagonist ( WEB 2086 ) , a recombinant human interleukin 1 receptor antagonist ( IL 1ra ) and a polyclonal antibody to recombinant bovine IL 1 beta ( anti rBoIL 1 beta ) was used to investigate the involvement of leukotrienes , PAF and IL 1 beta during endotoxin induced inflammation in the bovine teat cistern . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In this study , we report a total of 292 mouse embryos cultured on Vero cell monolayers and 77 embryos cultured in medium alone at different preimplantation stages examined individually for embryonic mRNA of beta actin , interleukin 1beta ( IL 1beta ) , interleukin 1 receptor antagonist ( icIL 1ra ) and interleukin 1 receptor type 1 ( IL 1RtI ) using reverse transcription and two step polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Priming by IL 1 beta was maximal at 100 ng / ml , was completely blocked in the presence of IL 1 receptor antagonist ( IL 1ra ) and , in the chemotaxis assay , was best observed at suboptimal ( 3 6 ng / ml ) or inactive ( 0 . 75 ng / ml ) concentrations of IL 8 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We characterized cytokines such as IL 1 beta , IL 8 , monocyte chemoattractant protein 1 ( MCP 1 ) , and cytokine inhibitors such as IL 1 receptor antagonist ( IL 1ra ) and soluble TNF receptors ( sTNFR p 55 + p 75 ) as well as PGE in the cell free culture supernatants . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : The production of interleukin ( IL ) 1 alpha IL 1 beta and IL 1 receptor antagonist ( IL 1ra ) by blood mononuclear cells ( MNC ) , as well as the corresponding serum levels of IL 1ra were examined in blood samples from umbilical cords ( n = 11 ) , children ( n = 40 ) and adults ( n = 20 ) , and in 42 patients with juvenile chronic arthritis ( JCA ) of the pauci or polyarticular onset type . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RESULTS : It showed that mRNA expression of IL 1 beta and IL 1r alpha were significantly lower in the group of preterm vaginal delivery resulting from premature rupture of membranes than that of preterm cesarean section with the indication of pregnancy induced hypertension and than that of full term delivery ( P < 0 . 001 ) . ^^^ CONCLUSIONS : It indicated that gene expression of IL 1 beta and IL 1r alpha probably related to the fetal maturity . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Different pattern of interleukin 1 beta ( IL 1 beta ) , interleukin 1 receptor antagonist ( IL 1ra ) and interleukin 1 receptor type 1 ( IL 1R tI ) mRNA expression in single preimplantation mouse embryos at various developmental stages . ^^^ Recent studies have documented immunohistochemical evidence of interleukin 1 beta ( IL 1 beta ) , interleukin 1 receptor antagonist ( IL 1ra ) and interleukin 1 receptor type 1 ( IL 1R tI ) in human preimplantation embryos and protein levels of interleukin 1 alpha ( IL 1 alpha ) , IL 1 beta and IL1ra in human preimplantation embryo culture fluid have been correlated with successful implantation and pregnancy . ^^^ Our aim in this study was to detect IL 1 beta , Il 1ra and Il 1R tI mRNA in single preimplantation mouse embryos and to describe the frequency of positive mRNA expression at different developmental stages . ^^^ Animals were sacrificed at day 0 . 5 , and zygotes were flushed from the tubes and cultured in HAMs F 10 medium . 2 cell ( 2C ) , 8 cell ( 8C ) , morula ( M ) , early blastocyst ( EB ) and hatching blastocyst ( HB ) stage embryos were examined by one round of reverse transcriptase ( RT ) followed by two rounds of polymerase chain reaction ( PCR ) carried out on individual mouse embryos for beta actin ( internal standard ) , IL 1 beta , IL 1ra and IL 1R tI mRNAs . ^^^ The frequencies of positive mRNA expressions were as follows ( 2C / 8C / M / EB / HB ) ; beta actin : 91 / 96 / 100 / 100 / 98 % ; IL 1b : 0 / 0 / 2 . 5 / 6 . 25 / 19 ; IL 1ra ; 0 / 5 / 30 / 41 / 74 % and IL 1R tI : 0 / 0 / 10 / 20 / 25 % . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta increased IL 1beta , IL 1 receptor types 1 and 2 ( IL 1RI and IL 1RII ) , IL 1 receptor accessory protein soluble form ( IL 1R AcP 2 ) , IL 1 receptor antagonist ( IL 1Ra ) , TNF alpha , and TGF beta 1 mRNAs in the hypothalamus from obese and lean rats . ^^^ The data suggest 1 ) the operation of an IL 1beta feedback system ( IL 1beta / IL 1RI / IL 1R Acp II / IL 1RII / IL 1Ra ) and 2 ) potential cytokine cytokine interactions with positive ( IL 1beta < > TNF alpha ) and negative ( TGF beta 1 > IL 1beta / TNF alpha ) feedback . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RT PCR revealed beta actin and IL 1R tI mRNA expression in Vero cell cocultures without detectable IL 1 beta and IL 1ra mRNA expression . ^^^ To determine the effect of IL 1 beta on IL 1R tI mRNA expression in Vero cells , quantitative competitive PCR methodology was developed . ^^^ A competitive cDNA fragment was coamplified as an internal standard with the target cDNA sequence of IL 1R tI , showing a 50 % decrease in Vero cell IL 1R tI cDNA cultured in the presence of IL 1 beta ( 100 IU / mI ) compared to control Vero cell cultures ( 62 . 5 fg vs . 125 fg ) . ^^^ Down regulation of IL 1R tI mRNA by IL 1 beta is dose dependent , with increasing concentrations ( 0 1000 ) IU / ml ) of IL 1 beta producing progressive attenuation of IL 1R tI expression . ^^^ Treatment with anti IL 1 beta antibody ablate the inhibitory effect of IL 1 beta ( 100 IU / ml ) on IL 1R tI mRNA expression . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Similar concurrent suppression of IL 1 beta and IL 1ra release occurred in PBMC and Mono Mac 6 cultures exposed to dexamethasone . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 beta mRNA and IL 1 receptor antagonist ( IL 1Ra ) mRNA were induced similarly , exhibiting highest and lowest expression levels in the hypothalamus and hippocampus , respectively . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
These results show that the production of IL 1 beta , TNF alpha and IL 1ra in blood disappears during chemotherapy induced neutropenia , not only due to the decreased number of producing cells , but also as a result of a decreased production per cell , suggesting a mechanism of downregulation . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The inhibitory effect of IL 1 beta could be counteracted by the IL 1 receptor antagonist ( IL 1ra ) , indicating that the inhibitory effect was mediated through the specific IL 1 receptor on the parathyroid cells . ^^^ IL 1ra abolished the upregulating effect of IL 1 beta on the CaRmRNA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Multiple cell markers were used in immunohistochemical staining to identify the cells expressing IL 1beta and IL 1R protein . ^^^ The sham animals ( n = 5 ) showed no or only a weak expression of IL 1R or IL 1beta mRNA . ^^^ The major cellular source of IL 1beta protein was glia ( astrocytes , oligodendrocytes , microglia , and scattered perivascular macrophages / monocytes ) , while neurons and sporadic microvascular endothelia showed IL 1R immunoreactivity . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In related experiments , macrophages from uninfected ICSBP / mice were shown to display a selective impairment in the mRNA expression of IL 12 p 40 but not IL 1alpha , IL 1beta , IL 1Ra , IL 6 , IL 10 , or TNF alpha in response to live parasites , parasite antigen , lipopolysaccharide , or Staphylococcus aureus . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 receptor antagonist ( IL 1Ra ) , as well as the interleukin 1 beta ( IL 1 beta ) gene response to immobilization stress ( IMS ) , was examined in the rat brain . ^^^ IL 1 beta and IL 1Ra mRNA levels peaked at approximately 0 . 5 and 2 4 hr , respectively . ^^^ The maximum mRNA levels of IL 1 beta were 15 fold higher than pre IMS levels , whereas those of IL 1Ra were 250 fold higher in the hypothalamus . 3 . ^^^ After the biosynthesis of IL 1 beta has peaked , IL 1Ra may contribute to attenuation of the IL 1 activity which has been enhanced by IMS . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Besides leukocytes , C3a , C5a , and limulus amebocyte lysate reactivity , tumor necrosis factor ( TNF ) alpha , interleukin ( IL ) 1 beta , IL 6 , IL 1RA , soluble TNF receptors , and IL 1 beta mRNA were assessed . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To further examine the relationship between estrogen deficiency and early postmenopausal bone loss , levels of IL 6 , IL 6sR , IL 1 alpha , IL 1 beta and IL 1ra were measured in bone marrow plasma and bone marrow cultures obtained from 40 postmenopausal women , half of whom were on estrogen replacement therapy . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Following i . p . administration of 50 mg / kg of oligonucleotide , significant increases in the splenic mRNA levels of IL 6 , IL 12p40 , IL 1 beta , and IL 1Ra and serum levels of IL 6 , IL 12 , MIP 1 beta , and MCP 1 were observed . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To investigate the effect of term labour without infection on the IL 1 system , the messenger ribonucleic acid ( mRNA ) expression of IL 1 beta , IL 1 receptor type 1 ( IL 1R tI ) , IL 1 receptor antagonist ( IL 1ra ) , and IL 1 beta converting enzyme ( ICE ) were examined by Northern blot analysis and by reverse transcriptase polymerase chain reaction ( RT PCR ) in paired samples of decidua and placenta obtained from women having spontaneous vaginal delivery ( group 1 ) or elective caesarean section ( group 2 ) at term . ^^^ In addition , concentrations of IL 1 beta and IL 1ra proteins were measured by ELISA in paired decidual and placental cytosols . ^^^ The IL 1ra / IL 1 beta ratio was significantly lower in decidual samples in women with spontaneous labour than in women without labour ( P < 0 . 05 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
No changes occurred in serum concentrations of IL 1 beta , IL 1ra , TNF alpha , or CRP . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
An imbalance of proinflammatory cytokines such as TNF alpha , IL 1 beta , and the neutrophil chemotactic factor IL 8 and inhibitors ( e . g . , soluble TNF receptors and IL 1ra ) in the lung during the first week of life may contribute to prolonged pulmonary inflammation and fibrosis in bronchopulmonary dysplasia ( BPD ) . ^^^ Lung lavage was collected on Day 3 ( pre study ) and Day 7 and analyzed for cell count and differential and TNF alpha , sTNFR 1 , sTNFR 2 , IL 1 beta , IL 1ra , and IL 8 concentrations . ^^^ There was a trend towards lower IL 1 beta levels in DSCG treated infants on Day 7 , but IL 1ra levels were unaffected by DSCG therapy . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Tumour necrosis factor alpha ( TNF alpha ) and interleukin 1 beta ( IL 1 beta ) are pro inflammatory cytokines that play an important role in severe infections , whereas IL 1 receptor antagonist ( IL 1ra ) and IL 10 are anti inflammatory cytokines that counteract their effects . ^^^ When peripheral blood mononuclear cells were stimulated in vitro with LPS , the addition of chlorpromazine ( 1 100 ng / ml ) had no modulatory action on TNF alpha , IL 1 beta , IL 1ra or IL 10 synthesis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 alpha , IL 1 beta , IL 1ra and the total IL 1 / IL 1ra ratio ( IL 1 activity index ; IL 1AI ) were measured in 75 gingival crevicular fluid ( GCF ) samples from non inflamed gingiva sites in 2 healthy subjects and diseased sites in 7 patients with several types of periodontitis . ^^^ IL 1 alpha , IL 1 beta and IL 1ra were measured by specific non cross reactive enzyme linked immunosorbent assay . ^^^ The total amount of IL 1 alpha , IL 1 beta and the IL 1AI , but not total IL 1ra , were found to be correlated with alveolar bone loss score . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The production of interleukin 1beta ( IL 1beta ) and interleukin 1 receptor antagonist ( IL 1Ra ) by peripheral blood mononuclear cells ( PBMC ) was examined in patients on long term acetate free biofiltration ( AFB ) . ^^^ IL 1beta and IL 1Ra production was measured by ELISA before and after dialysis in the last session of both treatments . ^^^ However , the spontaneous IL 1Ra / IL 1beta production ratio in AFB was significantly higher than that in BCD . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Nine of 10 stools tested had ratios of interleukin 1beta ( IL 1beta ) to IL 1 receptor antagonist ( IL 1ra ) of > 0 . 01 . ^^^ A review of the 18 available patient records revealed that fecal IL 8 concentrations , IL 1beta / IL 1ra ratios , and FLF titers were significantly higher in patients with moderate to severe disease than in patients with mild disease . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The cytokines assessed included IL 1 alpha , IL 1 beta , IL 1ra , IL 6 , IL 8 , IL 12 , IL 13 , TNF alpha , TGF beta , and IFN gamma . ^^^ Results showed that TNF alpha mRNA was present significantly more frequently in diseased than in healthy biopsies , whereas IL 1 alpha , IL 1 beta , and IL 1ra mRNA were found in most ( from 80 to 100 % ) healthy tissues . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
There was no significant difference between IL 1 beta and IL 1ra production from ex vivo monocytes between lupus patients and normals . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Pretreatment of neutrophils with GM CSF prior to EBV activation synergistically enhanced the production of IL 1 alpha and IL 1 beta , but only marginally affected IL 1Ra synthesis . ^^^ Molecular analysis showed that GM CSF did not alter the IL 1 beta and IL 1Ra mRNA synthesis induced by EBV , suggesting that GM CSF could act at a posttranslational level . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
However , identical doses of IL 1ra significantly reversed the effects of IL 1beta , administered either i . p . ( 5 microg / kg ) or i . c . v . ( 50 ng / rat ) , respectively . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : IL 1 alpha , IL 1 beta , and IL 1ra were measured by enzyme linked immunosorbent assay ( ELISA ) in biopsy specimens taken from inflamed and non inflamed colon of 60 patients with Crohn ' s disease ( CD ) , 34 with ulcerative colitis ( UC ) , 15 inflammatory controls , and 103 non inflamed controls . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The expression of IL 1beta , IL 1 Receptor 1 ( IL 1R1 ) , Il 1R2 , IL 1R antagonist ( IL 1Ra ) , and ICE mRNA within the pancreas was examined by quantitative differential RT PCR . ^^^ There was constitutive expression of pancreatic IL 1R1 , IL 1R2 , IL 1Ra , and ICE but not IL 1beta . ^^^ As pancreatitis developed , mRNA for IL 1beta , IL 1Ra , and ICE increased in parallel with the degree of pancreatitis severity ( all P < 0 . 001 vs baseline ) while mRNA for both receptors remained stable ( P=NS ) . ^^^ Intrapancreatic and systemic IL 1beta and IL 1Ra protein also increased as pancreatitis developed ( both P < 0 . 001 ) with tissue levels being continuously greater than serum . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The reductions in milk intake induced by mouse IL 1 beta were largely prevented by IL 1ra pretreatment ( 100 micrograms / mouse i . p . ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Serum and plasma samples were taken at intervals of 6 weeks 4 months and tested for IL 1Ra , IL 1 beta , IL 6 , IgG and anti dsDNA , Clq , C 3 , C 4 and C reactive protein ( CRP ) . ^^^ When disease activity was at its highest , IL 1Ra concentrations correlated with IL 1 beta ( r = 0 . 76 ; P < 0 . 001 ) , IL 6 ( r = 0 . 60 ; P < 0 . 01 ) and CRP ( r = 0 . 61 ; P < 0 . 01 ) , but not with C1q , C 3 , C 4 and anti dsDNA levels . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 receptor antagonist ( IL 1RA ) was added to patient sera to test the role of IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Human neuroblastoma cells SK N SH express significant numbers of IL 1R type 1 on their surface , as detected by saturation binding and RT PCR , and are responsive to IL 1beta activation by producing inflammatory cytokines IL 6 and IL 8 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Cellular RNA content was subjected to a solution hybridization , RNase protection assay with gel purified [ 32P ] UTP labelled antisense riboprobes for rat IL 1beta , type 1 IL 1 receptor ( IL 1R ) and secretory phospholipase A 2 ( sPLA 2 ) . ^^^ Treatment with IGF 1 resulted in a significant ( P < 0 . 01 ) decrease in type 1 IL 1R transcripts ( an effect which was reversed by co treatment with IL 1beta ) , was without effect on IL 1beta transcripts , and significantly ( P < 0 . 05 ) increased sPLA 2 gene expression ( an effect which was further enhanced by co treatment with IL 1beta ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We investigated long term effects of dietary n 3 fatty acids on circulating cytokine concentrations and on ex vivo stimulated whole blood production of IL 1 beta , TNF alpha and interleukin 1 receptor antagonist ( IL 1Ra ) , the naturally occurring antagonist of IL 1 . ^^^ In all groups , the production of IL 1 beta and IL 1Ra was higher during supplementation than afterwards . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Among the NSAIDs tested , mofezolac and sodium diclofenac were found to stimulate the mRNA expression for IL 1ra without affecting the mRNA expression for IL 1 beta . ^^^ Mofezolac suppressed the mRNA expression for IL 1 beta in PBMC stimulated with exogenous IL 1 beta , indicating the secreted IL 1ra in the presence of mofezolac to be biologically active . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
After 2 h , no intact IL 1beta , IL 6 , or IL 1ra were detectable . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The normal human monocyte production of TNF alpha , IL 1 beta and IL 1Ra was not significantly different when cells were incubated with OL or commercial replacement fluid . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The comparative polymerase chain reaction technique was used to evaluate mRNA for IL 6 , IL 1ra , IL 1beta and tumour necrosis factor ( TNF ) alpha in skeletal muscle and blood mononuclear cells ( BMNC ) ( n = 8 ) . ^^^ Increased amounts of mRNA for IL 1ra were found in two muscle biopsies and five BMNC samples , and increased amounts of IL 1beta mRNA were found in one muscle and four BMNC samples after exercise . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Presence of the IL 1RA allele 2 ( IL1RN * 2 ) is associated with enhanced IL 1beta production in vitro . ^^^ The genes of the interleukin 1 ( IL 1 ) complex code for three proteins : IL 1alpha , IL 1beta and the IL 1 receptor antagonist ( IL 1RA ) . ^^^ In the IL 1beta gene there are two base exchange polymorphisms in positions 511 and +3953 , and IL 1RA gene has a penta allelic polymorphic site in intron 2 containing variable numbers of an 86 bp tandem repeat sequence . ^^^ As the IL 1beta / IL 1RA ratio may be critical in the regulation of inflammation , we examined whether there are allelic associations between these loci ( thus suggesting co ordinate regulation ) and whether these have an effect on the in vitro production of IL 1beta . ^^^ We found that the IL 1RA allele 2 ( IL1RN * 2 ) is associated with the presence of allele 2 of the IL 1beta gene ( position 511 ) and with the absence of allele 2 of the IL 1beta gene ( position +3953 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
POPULATION AND METHODS : We examined production of interleukin 1 beta ( IL 1 beta ) , tumor necrosis factor alpha ( TNF alpha ) , IL 1 receptor antagonist ( IL 1Ra ) , and IL 6 in 711 elderly participants in the Framingham Heart Study ( mean age , 79 y ) and 21 young healthy volunteers ( mean age , 39 y ) . ^^^ IL 6 population correlated with IL 1 beta ( r = . 36 , p < . 0001 ) and TNF alpha production ( r = . 25 , p < . 0001 ) , but IL 1Ra production did not . ^^^ CONCLUSION : Production of IL 6 and IL 1Ra but not IL 1 beta or TNF alpha was increased in the elderly compared to healthy , young subjects . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
This study tested the hypotheses that sex related differences in circulating binding proteins for interleukin 1beta ( IL 1beta ) exist and that these binding proteins affect immunoassays for IL 1beta and IL 1Ra . 125I labeled IL 1beta was added to human plasma samples , then chromatographed . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In contrast , release of IL 1beta and IL 1ra ( IL 1 receptor antagonist ) in response to LPS , or LPS plus IFNgamma , was found to be lower in PMN from HIV positive patients than in PMN from controls , but was significant only in the case of IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
However , MG patients who were noncarriers of IL Ra allele 2 had a significantly higher percentage of IL 1beta TaqI RFLP allele 2 carriage ( OR = 3 . 085 ) , while there was no such difference in IL 1Ra allele 2 carriers . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 6 receptors ( IL 6R ) and interleukin 1 receptors ( IL 1R ) on lymphocyte surfaces were analyzed , using flow cytometry and dye labeled IL 6 and IL 1 beta , to examine the clinical and immunological significance of these receptors . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present study , the potential of two species of interleukin 1 ( IL 1 ) , IL 1alpha and IL 1beta , the IL 1 receptor antagonist ( IL 1ra ) and the synthetic chemotactic peptide N formyl methionyl leucyl phenylalanyl lysine ( fMLFK ) were directly compared in a rabbit model of infection . ^^^ IL 1alpha , IL 1beta , IL 1ra and fMLFK were labelled with iodine 123 according to the Bolton Hunter method . ^^^ After 20 h p . i . , the highest abscess to contralateral muscle ratios were obtained with 123I IL 1beta , i . e . 39 . 0+ / 11 . 5 vs 18 . 7+ / 5 . 4 , 18 . 1+ / 2 . 3 and 29 . 9+ / 7 . 0 for 123I IL 1alpha , 123I IL 1ra and 123I fMLFK , respectively . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Consistent with the identification of IL 1beta as the lymphocyte factor , fibroblast or mesangial cell IL 8 release induced by the IgG stimulated lymphocyte supernatants was inhibited by 1 ) the combination of IL 1R antagonist and soluble type 2 IL 1R , 2 ) an IL 1 converting enzyme inhibitor , or 3 ) anti IL 1beta but not preimmune Abs . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
CONCLUSION : Diacerhein and rhein can effectively inhibit the synthesis of IL 1beta on human OA synovium , as well as the action of this cytokine at the cartilage level , by reducing the number of chondrocyte IL 1R . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Therefore , in our continuing investigation to clarify the significance of leukocytosis and its prolongation in prostatic fluid from prostatitis patients , we investigated whether low levels of IL 1ra versus IL 1 beta secreted in prostatic fluid were the cause of prolonged prostatitis , especially nonbacterial prostatitis ( NBP ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To elucidate pathophysiological roles of IL 1 , we have first produced IL 1alpha / beta doubly deficient ( KO ) mice together with mice deficient in either the IL 1alpha , IL 1beta , or IL 1 receptor antagonist ( IL 1ra ) genes . ^^^ Fever development upon injection with turpentine was suppressed in IL 1beta as well as IL 1alpha / beta KO mice , but not in IL 1alpha KO mice , whereas IL 1ra KO mice showed an elevated response . ^^^ In IL 1beta KO mice treated with turpentine , the induction of cyclooxygenase 2 ( EC 1 . 14 . 99 . 1 ) in the diencephalon was suppressed , whereas it was enhanced in IL 1ra KO mice . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 alpha ( IL 1 alpha ) , IL 1 beta , interleukin 1 receptor type 1 ( IL 1RI , signaling receptor ) , and IL 1 receptor antagonist ( IL 1Ra , endogenous inhibitor ) are pivotal components of the IL 1 system . ^^^ We investigated the levels of IL 1 alpha , IL 1 beta , IL 1RI , IL 1Ra , and TGF beta 1 mRNAs in pediatric astrocytomas ( n = 19 ) , ependymomas ( n = 13 ) , and primitive neuroectodermal tumors ( n = 22 ) using sensitive and specific RNase protection assays . ^^^ Pilocytic , nonpilocytic , and anaplastic astrocytomas have significant increased levels of IL 1 beta , IL 1RI , and TGF beta 1 mRNAs , but low levels of IL 1Ra mRNA ; this may have implications for an IL 1 beta feedback system and IL 1 beta < > TGF beta 1 interactions in astrocytomas . ^^^ Ependymomas show increased levels of IL 1 alpha and IL 1 beta mRNAs associated with low levels of IL 1Ra mRNA ; primitive neuroectodermal tumors do not exhibit increased levels of any cytokine component examined . ^^^ Interleukin 1 alpha ( IL 1 alpha ) , IL 1 beta , IL 1 receptor type 1 , IL 1 receptor antagonist , and TGF beta 1 mRNAs in pediatric astrocytomas , ependymomas , and primitive neuroectodermal tumors . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
CONCLUSION : Thus , we could not confirm the results of a previous study reporting an association between the IL 1ra and IL 1 beta gene polymorphisms in patients with inflammatory bowel disease . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The results suggest that : ( 1 ) endogenous up regulation of IL 1beta and TNF alpha in the hypothalamus contribute to LPS induced anorexia ; and ( 2 ) the ratio IL 1Ra / IL 1beta , and IL 1beta < > TNF alpha interactions may have implications for gram negative infections associated with high levels of LPS in the brain cerebrospinal fluid . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : Serum levels of IL 1beta , IL 1ra , IL 6 , IL 8 , ICAM 1 and VCAM 1 were measured using ELISA in 10 patients with active ANCA positive renal vasculitis ( 5 patients with Wegener ' s granulomatosis , WG , and 5 patients with microscopic polyangiitis , MPA ) during the course of therapeutic PE . ^^^ On the other hand , there was no change in serum levels of IL 1beta and IL 8 , and the serum levels of IL 1ra and IL 6 even increased at the end of a single PE , in spite of high levels of all cytokines and adhesion molecules in the plasma filtrate . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
An in vitro system composed of a plasma separation membrane coupled with natural ( charcoal ) or synthetic ( Amberlite , Amberchrome ) types of sorbents was evaluated for the simultaneous removal of proinflammatory cytokines ( TNF alpha , IL 1 beta and IL 8 ) and cytokine antagonists [ interleukin ( IL ) 1 receptor antagonist ( IL 1Ra ) , soluble tumor necrosis factor alpha ( TNF alpha ) receptor 1 and 2 ( sTNFR 1 and 2 ) ] in whole blood spiked with bacterial lipopolysaccharide ( LPS ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Membranes were stained by immunohistochemical techniques with monoclonal antibodies against TNFalpha , IL 8 , IL 1beta , and the IL 1 receptor antagonist protein ( IL 1Ra ) . ^^^ No effect on synovial membrane IL 1beta and IL 1Ra or synovial fluid IL 1beta and PGE 2 was found . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To test this hypothesis , diseased and healthy gingival biopsies were examined for differences in the expression of cytokine mRNA for the pro inflammatory cytokines tumor necrosis factor alpha and IL 1 beta and the anti inflammatory cytokine IL 1ra using quantitative reverse transcriptase polymerase chain reaction and in situ hybridization methods . ^^^ Additionally , a significantly correlated expression of IL 1 beta and IL 1ra mRNA was seen in all tissue examined . ^^^ Although both diseased and healthy tissues expressed IL 1 beta and IL 1ra mRNA in the epithelium , the diseased tissue biopsies expressed more IL 1 beta and IL 1ra mRNA in the connective tissue . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The purpose of the present study was to determine 1 ) whether the intracerebroventricular injection of IL 1 beta can influence peripheral IGF 1 levels in control animals and 2 ) whether the central administration of a IL 1 receptor antagonist ( IL 1ra ) can prevent the changes in peripheral IGF 1 induced by endotoxin [ lipopolysaccharide ( LPS ) ] or sepsis produced by cecal ligation and puncture . ^^^ These data suggest that , although central IL 1 beta is capable of modulating peripheral IGF 1 levels , central administration of IL 1ra was unable to modulate the changes in peripheral IGF 1 in blood and tissues produced by either endotoxemia or peritonitis . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Presynaptic effects of IL 1 beta and the IL 1 receptor antagonist ( IL 1ra ) on glutamate release and calcium entry were investigated in isolated nerve terminals ( synaptosomes ) prepared from the striatum . ^^^ Neither rat recombinant IL 1 beta ( rrIL 1 beta : 0 . 01 2 nM ) or human recombinant IL 1ra ( hrIL 1ra : 0 . 2 microM ) had any significant effect on the KCl evoked glutamate efflux or calcium entry in striatal synaptosomes , indicating that their actions are unlikely to be presynaptic . ^^^ Thus , our data suggest that IL 1 beta and IL 1ra influence neuronal damage in the striatum by acting to modify events that occur after excitatory amino acid receptor activation . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Kinetics of IL 8 , MIP 1 alpha , TNF alpha , IL 1 beta , IL 1ra and IL 10 in human whole blood samples triggered by smooth and rough LPS . ^^^ An in vitro model for the study of sepsis mediators was used to investigate the effects of two different lipopolysaccharides ( LPS ) , a smooth ( LPS S ) and a rough ( LPS R ) type , on the release of chemokines ( IL 8 and MIP 1 alpha ) and cytokines ( TNF alpha , IL 1 beta , IL 1ra and IL 10 ) from human whole blood samples . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The objective of the study was to investigate involvement of TNF alpha , IL 1 beta and IL 1 receptor antagonist ( IL 1Ra ) in lipopolysaccharide ( LPS ) induced uveitis . ^^^ Immunohistochemistry and leukocyte depletion studies showed that infiltrating leukocytes were the major cellular sources of aqueous TNF alpha , IL 1 beta and IL 1Ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present study , we analyzed the cytokine network among TNFalpha , IL 1beta , IL 8 , and IL 1 receptor antagonist ( IL 1Ra ) in a rabbit experimental model of acute gout . ^^^ The source of TNFalpha and the first phase of IL 8 was synovial cells , whereas infiltrating leukocytes were the source of the second phase of IL 8 and also of IL 1beta and IL 1Ra . ^^^ These results provide evidence that IL 8 and TNFalpha were responsible for the production of IL 1beta and IL 1Ra , and that IL 1beta was responsible for the second phase of IL 1beta and IL 8 production . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Whole blood functional assays indicated that sufficient s ( CHO ) IL 1R was present in the circulation at top dose levels to inhibit the in vitro effects of IL 1beta on IL 8 induction ; however , no effect on IL 2 induced IL 8 induction , or on the IL 1beta or IL 2 induced tumor necrosis factor production , was observed . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present study , we evaluated members of the IL 1 family ( IL 1beta , IL 1 receptor antagonist ( IL 1Ra ) and IL 1 soluble receptors Type 1 and Type 2 ( IL 1sRI and IL 1sRII ) in 23 patients with HCL . ^^^ In contrast to the above , levels of IL 1Ra increased during response to treatment and clinical response to 2 CDA was associated with an increase of 122 % in IL 1Ra levels , in parallel with a decrease of 63 % in IL 1beta and 47 % in IL 1sRII levels . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
DESIGN : We examined the effect of IL 13 on the synthesis and expression of interleukin 1 beta ( IL 1 beta ) , tumor necrosis factor alpha ( TNF alpha ) , IL 1 receptor antagonist ( IL 1Ra ) and stromelysin 1 on human OA synovial membrane in ex vivo cultures . ^^^ This included determination of the levels of IL 1 beta and TNF alpha receptor binding , IL 1Ra and TNF soluble receptors 55 and 75 ( TNF sR 55 and TNF sR 75 ) . ^^^ RESULTS : In OA synovial membrane treated with LPS , IL 13 inhibited the synthesis of IL 1 beta , TNF alpha and stromelysin 1 , but increased IL 1Ra production . ^^^ In addition , IL 13 reduced the level of IL 1 beta mRNA and stimulated the level of IL 1Ra mRNA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1Ra was able to significantly suppress the ACTH response to an i . c . v . injection of recombinant human IL 1 beta ( 50 ng ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1Ra is structurally similar to IL 1beta but lacking agonist activity is used in clinical trials to reduce disease severity . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
All patients showed increased counts for total cells , alveolar macrophages , neutrophils and lymphocytes , and markedly elevated concentrations of proteins , lactate dehydrogenase , IL 1beta , IL 6 , IL 8 , TNF alpha and IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Mice deficient in IL 1 beta , IL 1 beta converting enzyme ( ICE ) and IL 1R type 1 have also been studied . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We also describe an additional member of the IL 1 family : the IL 1 receptor antagonist ( IL 1ra ) , an endogenous antagonist to IL 1 alpha and IL 1 beta . ^^^ IL 1 beta induced fever can be blocked by IL 1ra pretreatment . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We conclude that IL 1 alpha and IL 1 beta production in the brain is induced in the same cell types , whereas IL 1ra is expressed constitutively by a different cell type probably neurons . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
This analgesia , as well as the intraPOA IL 1 beta induced hyperalgesia , was completely blocked by IL 1Ra or Na salicylate . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 beta stimulated the secretion of CRH from 19 . 2 + / 4 pg / mg protein ( n = 5 at 36 hours ) to 38 . 7 + / 4 , an effect blocked by IL 1ra in excess . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Among naturally occurring interleukin 1 ( IL 1 ) inhibitors , IL 1 receptor antagonist ( IL 1ra ) is a 22 kDa protein that shares homology with IL 1 beta and IL 1 alpha , binds to IL 1 receptor with similar affinity to IL 1 , and has no known agonist properties . ^^^ In this study , we measured the periapical exudate ( PE ) levels of IL 1 beta and IL 1ra from human periapical lesions . ^^^ PE samples were collected from root canals during routine endodontic treatments , and the enzyme linked immunosorbent assay was used to measure PE IL 1 beta and IL 1ra . ^^^ Detectable levels of both IL 1 beta and IL 1ra were found in 25 of 29 clinical samples . ^^^ Relatively high levels of IL 1ra compared with IL 1 beta ( mean IL 1ra : IL 1 beta ratio = 128 : 7 ; range : 0 . 9 to 495 . 4 ) , and significantly positive correlation between IL 1ra and IL 1 beta levels was found . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1 family comprises two bioactive proteins , IL 1alpha and IL 1beta , and their natural antagonist IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Recombinant bovine IL 1ra produced in Escherichia coli suppressed the growth inhibitory activity of bovine IL 1beta on A 375 cells in a dose dependent manner , indicating that the present bovine IL 1ra cDNA encodes biologically active proteins . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Freshly homogenized biopsies from involved tissue in IBD patients exhibited significantly lower IL 1Ra / IL 1beta ratios than control and uninvolved IBD mucosal tissue . ^^^ Using explant cultures , in vitro production of IL 1beta and IL 1Ra increased progressively during the 4 18 h culture periods . ^^^ Similar to freshly homogenized tissue , explant studies showed that the IL 1Ra / IL 1beta ratios were significantly decreased in involved IBD tissue , but not in uninvolved CD or inflammatory control specimens . ^^^ These data support the hypothesis of an imbalance between IL 1beta and IL 1Ra in IBD . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The study reported here , using an rt multiplex polymerase method , determined the presence or absence of transcripts in freshly obtained AML cells for the following cytokine or cytokine related genes : IL 1beta , IL1ra , TNF alpha , GMCSF , IL 6 , flt 3 , and hSCF . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present study , we investigated the regulation of IL 1ra protein by IL 1 beta ( 1 100 U / mL ) in human somatotroph adenomas ( n = 9 ) cultured for 12 48 h . ^^^ IL 1 beta significantly enhanced the concentration of IL 1ra dose dependently in the somatotroph adenoma cell lysates , whereas IL 1ra concentrations remained unchanged in the culture supernatants . ^^^ The regulation of IL 1ra in somatotroph adenoma cells is different from human cultured monocytes , in which IL 1 beta significantly stimulated IL 1ra secretion into the culture supernatants , and no change of intracellular IL 1ra content was observed . ^^^ Enhancement of intracellular IL 1ra protein by IL 1 beta may represent a mechanism intrinsic to somatotroph adenoma cells to counterregulate the response to IL 1 beta on hormone secretion or cellular growth . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Since an antisense oligonucleotide for IL 1 beta , a blocking Ab to IL 1 beta , and preincubation with the IL 1R antagonist all prevent the delay in apoptosis , we conclude that IL 1 beta acts in an autocrine manner to inhibit granulocyte programmed cell death . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Levels of pulmonary interleukin 6 ( IL 6 ) , tumor necrosis factor alpha ( TNF alpha ) , granulocyte colony stimulating factor ( G CSF ) , IL 1 receptor antagonist ( IL 1ra ) , and IL 10 mRNA , as well as hepatic IL 1beta , IL 6 , gamma interferon ( IFN gamma ) , G CSF , inducible nitric oxide synthase , and IL 10 mRNA , were reduced in MPL pretreated mice after CLP compared to control mice . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We cross sectionally analyzed the relationship of IL 1 beta and IL 1ra levels to leucocyte count in terms of interval between clinical onset and lumbar puncture . ^^^ The molar ratio of IL 1ra to IL 1 beta was thus lowest between 12 and 24 hours after onset ( median : 2341 ) , which coincided with the peak increase in leucocyte count . ^^^ The results are compatible with the idea that IL 1ra should be important for the regulation of IL 1 beta activity associated with leucocyte migration in aseptic meningitis . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The endogenous interleukin 1 receptor antagonist ( IL 1ra ) , a protein with partial homology with the proinflammatory cytokine interleukin 1beta ( IL 1beta ) , prevents binding of IL 1beta to the signalling receptor . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta mRNA and IL 1Ra mRNA were also significantly upregulated in the spleen of tumor bearing rats . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In contrast , a diffuse cytoplasmic staining was evident for IL 1ra , IL 1alpha and IL 1beta production . ^^^ IL 1ra , IL 1alpha and IL 1beta were also the dominating cytokines , expressed in up to 85 % of the DC , after 3 h of LPS stimulation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta receptor antagonist ( IL 1ra ) , which interferes with the interaction of IL 1beta with target cells , also abolished the inhibitory effects of IL 1beta on hepatocyte DNA synthesis as well as IL 1beta induced iNOS gene expression . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In a second series of experiments , HMG CoA synthesis inhibitors were ineffective to change the LPS induced production by PBMC of IL 1alpha , IL 1beta , IL 1 receptor antagonist ( IL 1ra ) , IL 6 , and TNFalpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The site of action of IL 1beta in such damage is not known , but we have demonstrated previously that injection of the interleukin 1 receptor antagonist ( IL 1ra ) in the striatum but not the cortex of rats inhibits damage caused by permanent middle cerebral artery occlusion . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The interleukin 1 ( IL 1 ) family comprises IL 1 alpha and IL 1 beta and an endogenous IL 1 receptor antagonist ( IL 1ra ) . ^^^ It was later proposed as a member of the IL 1 family , based on protein sequence homology with IL 1 beta and IL 1ra , and has tentatively been called IL 1 gamma . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 receptor antagonist ( IL 1Ra ) plasma levels are co ordinately regulated by both IL 1Ra and IL 1beta genes . ^^^ These IL 1beta allelisms did not have a direct influence on plasma IL 1Ra levels , but the enhancing effect of IL 1 Ra allele 2 on IL 1 Ra plasma levels required the presence of the IL 1beta 511 allele 2 or absence of the IL 1beta +3953 allele 2 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
There are three members of the IL 1 gene family : IL 1 alpha , IL 1 beta , and IL 1ra , IL 1 alpha , and IL 1 beta are both antagonist molecules with many proinflammatory effects . ^^^ IL 1ra is an antagonist molecule that can inhibit the effect of IL 1 alpha and IL 1 beta by specifically blocking the IL 1 receptor on target effector cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present study , we showed that activin A inhibited the production of interleukin 1beta ( IL 1beta ) , a potent proinflammatory cytokine , and enhanced the production of IL 1 receptor antagonist ( IL 1ra ) , in activated THP 1 and U 937 human monocytic cells , resulting in the reduction of IL 1 biologic activity . ^^^ Northern blot analysis revealed that activin A had no effect on mRNA accumulation of IL 1beta and IL 1ra , indicating that activin A regulates IL 1beta and IL 1ra production at a posttranscriptional level . ^^^ Taken together , these findings suggest that activin A may function as an anti inflammatory cytokine by modulating mature IL 1beta and IL 1ra production in inflammatory sites . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Serum levels of interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1ra ) , tumour necrosis factor alpha ( TNF alpha ) , IL 6 , soluble IL 6 receptor ( sIL 6R ) , soluble intercellular adhesion molecule 1 ( sICAM 1 ) and soluble E selectin were measured in 15 patients with newly diagnosed polymyalgia rheumatica ( PMR ) before and after 3 months of corticosteroid therapy . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
INTERVENTIONS : Measurement of plasma concentrations of interleukin 1beta ( IL 1beta ) , interleukin 1 receptor antagonist ( IL 1ra ) , interferon 7 ( IFN gamma ) and tumour necrosis factor alpha ( TNF alpha ) were measured by enzyme linked immunosorbent assays ( ELISA ) . ^^^ RESULTS : The concentration of IL 1beta and IL 1ra were increased in all patients and highest at the time of admission . ^^^ Concentrations of IL 1beta and IL 1ra were higher in patients who developed infective complications than in those who did not ( interleukin 8 ( IL 8 ) has previously been shown to follow this pattern as well ) . ^^^ Patients who survived had significantly higher IL 1beta concentrations than those who died ( 13 ( 1 ) compared with 3 ( 1 ) pg / ml , p = 0 . 005 ) CONCLUSION : There are significant time dependent changes in plasma concentrations of IL 1beta , IL 1ra , IFN gamma and TNF alpha after serious burns . ^^^ IL 1ra concentrations may be influenced by size of the burn and the acute phase response ; IL 1beta , IL 1ra and IL 8 may have a role in the host ' s response to infection ; and IL 1beta may influence outcome . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : To examine the association of peripheral blood mononuclear cell ( PBMC ) derived interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1Ra ) , tumor necrosis factor alpha ( TNF alpha ) , and radiographic osteoarthritis ( OA ) in the elderly . ^^^ PBMC derived IL 1beta , IL 1Ra , and TNF alpha production was assessed using a non cross reacting polyclonal radioimmunoassay . ^^^ RESULT : No uniform associations were found for IL 1beta or IL 1Ra in men , or for TNF alpha production and radiographic OA in either sex . ^^^ However , women with the highest production of IL 1beta and IL 1Ra had respectively higher rates of knee OA and lower rates of hand OA than expected . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In 5 patients , immunoperoxidase staining for the cytokines tumor necrosis factor alpha ( TNF alpha ) , interleukin 8 ( IL 8 ) , and IL 1beta as well as the IL 1 receptor antagonist protein ( IL 1ra ) was performed . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1alpha , IL 1beta and IL 1 receptor antagonist , IL 1RA ) regulate , in several ways , the inflammatory reactions of the body . ^^^ Alleles of these two loci are known to be associated , but in the seronegative patients this association was abnormal : 11 out of 20 ( 55 % ) were of the IL 1RA 2 negative / IL 1beta 2 negative type , while of the seropositive patients , 25 % were of this type ( P < 0 . 01 , chi 2 test ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Cell associated cytokine concentration ( like IL 1 beta and IL 1Ra ELISA ) was determined on mononuclear cell lysates . ^^^ No intradialytic ( for IL 1beta ) ( from 14 . 1+ / 3 . 0 to 13 . 5+ / 2 . 9 pg / 2 . 5 10 10 ( 6 ) cell ) and interdialytic ( for IL 1Ra ) ( from 4572+ / 1076 to 5408+ / 615 pg / 2 . 5 10 10 ( 6 ) cell ) cell associated cytokine expression was induced by hemofiltration . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
CONCLUSIONS : Human endometrial cells produce IL 1 ( mainly IL 1beta ) and IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Adult male rats were injected i . p . with saline or 2 . 5 or 5 . 0 microg of IL 1beta or were pretreated with 500 microg of IL 1 receptor antagonist ( IL 1ra ) followed 5 min later by 5 microg of IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the study presented , cells of a herniated lumbar disc were cultivated in vitro and analysed for interleukin 1beta ( IL 1beta ) and interleukin 1 receptor antagonist ( IL 1Ra ) production . ^^^ The objective of this study was the detection of IL 1beta and IL 1Ra secreted by herniated lumbar discal cells after discectomy . ^^^ Discal cells were isolated , cultures and culture supernatants immunochemically analysed for IL 1beta and IL 1Ra secretion . ^^^ Our findings might contradict recent studies on the role of IL 1beta and IL 1Ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHOD : Two hundred RA affected sibling pair families were genotyped for informative microsatellite markers mapping within or less than 3cM from : INF alpha , INF gamma , INF beta , IL 1 alpha , IL 1 beta , IL1R , IL 2 , IL 6 , IL5R , IL8R , BCL 2 , CD40L , NOS 3 , NRAMP , alpha 1 anti trypsin , and alpha 1 anti chymotrypsin , using fluorescence based automated technology . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Changes in the levels of IL 1 ( IL 1alpha , IL 1beta , and its receptor antagonist , IL 1RA ) occur upon keratinocyte differentiation in vitro and are associated in vivo with abnormal differentiated and hyperproliferative states of psoriatic keratinocytes . ^^^ Thus , we were able to detect precisely the regulation of IL 1 / IL 1RA intracellular levels during the keratinocyte cell cycle and differentiation , showing notably decreased IL 1beta upregulation in psoriatic keratinocytes progressing through the cell cycle . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In whole blood samples the lipopolysaccharide ( LPS ) stimulated release of TNF alpha , IL 6 and IL 1RA increased initially , whereas IL 1beta , IL 10 and IL 12 decreased . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Expression of beta actin ( external standard ) , IL 1beta , IL 1 receptor antagonist ( IL 1ra ) and IL 1 receptor ( IL 1R ) type 1 mRNA were related to embryonic development and IVF outcome . ^^^ Blastomeres from 12 embryos were examined : beta actin and IL 1R type 1 mRNA were detected in all blastomeres ( 100 % ) whereas IL 1beta could be detected in only nine of the blastomeres ( 75 % ) . ^^^ IL 1ra was expressed in only two ( 17 % ) of the blastomeres and those were simultaneously positive for IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
BACKGROUND : An imbalance between the proinflammatory cytokine interleukin 1 beta ( IL 1 beta ) and the anti inflammatory cytokine IL 1 receptor antagonist ( IL 1ra ) has been postulated as a pathogenic factor in inflammatory bowel disease ( IBD ) . ^^^ AIMS : To study allelic frequencies of novel polymorphisms in the genes for IL 1 beta and IL 1ra in patients with IBD and to assess the relation between ex vivo cytokine production and allelic variants of the IL 1 beta and IL 1ra genes . ^^^ METHODS : Genotyping was performed by polymerase chain reaction and subsequent cleavage with specific endonucleases ( Mwo 1 , MspAI 1 , Alu 1 , Taq 1 , BsoF 1 ) for five novel restriction fragment length polymorphisms ( RFLPs ) in the genes for IL 1ra and IL 1 beta . ^^^ RESULTS : No significant differences were found in the allelic frequencies or allele carriage rates of the markers in the IL 1 beta and IL 1ra genes between CD , UC , and healthy controls . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Levels of interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1ra ) , interleukin 6 ( IL 6 ) , tumor necrosis factor alpha ( TNF alpha ) , the soluble TNF receptors type 1 and 2 ( sTNFR 1 and 2 ) , and the acute phase protein alpha 1 antichymotrypsin ( x 1 ACT ) were determined in paired serum and CSF samples taken yearly over a period of 2 5 years from pathologically confirmed AD patients ( n = 8 ) and normal controls or non AD subjects with other CNS pathology ( n = 9 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
MEASUREMENTS AND MAIN RESULTS : Plasma concentrations of TNF alpha , interleukin ( IL ) 1beta IL 6 , IL 8 , IL 10 , soluble 75 kilodalton TNF alpha receptor ( sTNFR 75 ) , and IL 1beta receptor antagonist ( IL 1ra ) were measured by sandwich enzyme linked immunosorbent assay before cA 2 infusion , 8 hrs later , and then daily for a minimum of 4 days . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The conditioned medium from cultures and the serum were then assayed for interleukin 6 ( IL 6 ) , IL 1alpha IL 1beta , IL 1 IL 1ra , tumor necrosis factor alpha ( TNF alpha ) , and granulocyte macrophage colony stimulating factor ( GM CSF ) by enzyme linked immunosorbent assay . ^^^ A significantly higher ratio of IL 1beta / IL 1ra ( p = 0 . 02 ) in LPS stimulated WB cultures was seen in the untreated women . ^^^ Levels of IL 1beta and IL 1alpha measured in WB cultures were lower and IL 1ra was higher in the ERT treated group but these results were not significant . ^^^ We conclude that estrogen may prevent bone loss following the menopause by altering the balance between IL 1beta and IL 1ra . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present study , we examined the effect of RA on IL 1beta and IL 1ra production by human alveolar macrophages in order to clarify the mechanism in pulmonary infiltration of neutrophils , since IL 1 has been shown to initiate neutrophil recruitment into the lung through up regulated expression of adhesion molecules on vascular endothelium . ^^^ RA enhanced IL 1beta and inhibited IL 1ra production by 4beta phorbol 12beta myristate 13alpha acetate ( PMA ) and lipopolysaccharide ( LPS ) stimulated human alveolar macrophages . ^^^ These results show that RA differentially regulates IL 1beta and IL 1ra production by alveolar macrophages and indicate that an imbalanced production between IL 1beta and IL 1ra may contribute to initiating neutrophil recruitment into the lung through up regulated expression of adhesion molecules . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Incubation of rSAA , plasma HDL ( which contains < or = 30 microg / ml of SAA ) or HDL rSAA complex with THP 1 cells induced synthesis of IL 1beta , IL 1ra and sTNFR 2 protein and mRNA . ^^^ In contrast 10 microg / ml LPS stimulated secretion of the inflammatory cytokines , IL 1beta , IL 6 and TNFalpha , as well as IL 1ra and sTNFR 2 from THP 1 cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In cell cultures , the LPS induced release of the inflammatory cytokines doubled for IL 1beta ( P < 0 . 0001 ) and for IL 1ra ( P < 0 . 0001 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : We measured the urinary excretion of IL 1ra and IL 1beta during the first 3 6 posttransplant weeks in 23 patients with acute rejection ( 69 24 hr urine samples ) and in 17 patients with stable graft function ( 51 24 hr urine samples ) and expressed the results as cytokine / creatinine ratios . ^^^ RESULTS : Within the follow up time , patients with rejection had higher urinary IL 1beta / creatinine ( ng / mmol ) ratios ( median 5 . 0 vs . 2 . 7 ; P < 0 . 005 ) , lower IL 1ra / creatinine ( ng / mmol ) ratios ( median 18 . 1 vs . 34 . 2 ; P < 0 . 1 ) , and consequently lower IL 1ra / IL 1beta ratios ( median 3 . 6 vs . 20 . 3 , P < 0 . 005 ) , compared with patients without rejection . ^^^ In rejecting patients , IL 1ra / creatinine was constantly low and decreased even further during acute rejection , whereas IL 1beta / creatinine ratios increased from a median prerejection value of 3 . 5 ( range not measurable to 9 . 0 ) to a median value of 8 . 1 ( P < 0 . 0005 ) ( range 1 . 6 to 18 . 3 ) during rejection . ^^^ CONCLUSION : These results suggest that patients who produce high amounts of IL 1ra in relation to IL 1beta are less prone to acute allograft rejection than patients with low IL 1ra / IL 1beta ratios . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
After 24 hs , the plasma was assayed for tumor necrosis factor alpha ( TNF alpha ) , IFN gamma , IL 1beta , IL 1 receptor antagonist ( IL 1Ra ) , and IL 8 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Release of interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1Ra ) , tumor necrosis factor a , and soluble tumor necrosis factor receptors ( sTNFR ) p 55 and p 75 during the differentiation in vitro was assessed by immunoassay in the culture supernatants . ^^^ MTX had fewer effects on phenotypic differentiation of human BMMC and PBMC , but did stimulate IL 1Ra release and inhibit IL 1beta synthesis in BMMC . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The interleukin 1 receptor antagonist ( IL 1ra ) is a naturally occurring molecule that shares homology with IL 1alpha and IL 1beta and binds competitively to IL 1 receptors . ^^^ Serum concentrations of IL 1ra were measured by ELISA in patients enrolled in Phase 1 clinical trials of IL 1alpha and IL 1beta given by 15 min infusion . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
This results in a shift towards pro inflammatory cytokine production , as indicated by a decreased IL 1ra / IL 1beta ratio . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In contrast , a diffuse cytoplasmic staining was evident for IL 1ra , IL 1alpha and IL 1beta production . ^^^ IL 1ra , IL 1alpha and IL 1beta were also the dominating cytokines , expressed in up to 85 % of the DC , after 3 h of LPS stimulation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The recently described IL 1R accessory protein ( IL 1R AcP ) interacts with IL 1beta and the IL 1 type IR ( IL 1RI ) , but an essential requirement for IL 1R AcP in IL 1 signaling in vitro has not been established and its role in vivo has not been examined . ^^^ IL 1R AcP deficient fibroblasts bound murine IL 1alpha and human IL 1R antagonist protein ( IL 1Ra ) with only moderately reduced affinity when compared with wild type cells , whereas murine IL 1beta affinity was reduced by 70 fold . ^^^ These data demonstrate that a type 1 IL 1R / IL 1R AcP complex is required for signaling by all IL 1 agonists and for high affinity binding by IL 1beta . ^^^ IL 1R AcP deficient fibroblasts bound murine IL 1alpha and human IL 1R antagonist protein ( IL 1Ra ) with only moderately reduced affinity when compared with wild type cells , whereas murine IL 1beta affinity was reduced by 70 fold . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Human embryos express IL 1beta , IL 1 receptor type 1 ( IL 1RtI ) , and IL 1 receptor antagonist ( IL 1RA ) at both the mRNA and protein levels . ^^^ We used stringent cell separation techniques combined with reverse transcription polymerase chain reaction to investigate the expression of various IL 1 system genes ( IL 1alpha , IL 1beta , IL 1RtI , and IL 1RA ) in human gametes and cumulus cells . ^^^ On the other hand , IL 1alpha , IL 1beta , and IL 1RtI mRNAs were not found in either unfertilized or fertilized human oocytes , and a very few metaphase 2 human oocytes had transcripts for either secreted ( 10 % ) or intracellular ( 17 % ) IL 1RA . ^^^ However , the abundant expression of IL 1alpha , IL 1beta , the IL 1RtI , and its antagonist IL 1RA by human cumulus cells provides further evidence that the IL 1 system plays a role in human ovarian physiology . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We also attempted to analyze the inflammatory cytokine network among TNFalpha , IL 1beta , IL 8 , and IL 1Ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Therefore the effects of the IL 1 family ( IL 1alpha ( 1 ng / ml ) , IL 1beta ( 1 ng / ml ) and the IL 1 receptor antagonist ( IL 1ra ) ( 10 ng / ml ) ) on the regulation of prostaglandin synthesis in term human fetal membranes were investigated . ^^^ However , in combination treatments , IL 1ra did not inhibit IL 1alpha or IL 1beta stimulated PGE 2 output , and increased PGE 2 production further compared with IL 1beta alone . ^^^ IL 1ra decreased IL 1beta induced COX 2 mRNA expression by about half and significantly increased cPLA 2 protein levels , as detected by immunoblotting , when used alone and together with IL 1beta . ^^^ These results suggest that IL 1ra has partial agonist properties when used together with IL 1alpha and IL 1beta in fetal membranes by increasing cPLA 2 protein levels , which leads to an increase in the production of prostaglandins . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
It has been previously demonstrated that the endogenous synthesis of interleukin 1 receptor antagonist ( IL 1Ra ) is a reliable marker of the level of IL 1 beta synthesis in hemodialysis ( HD ) patients . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Here we investigated the expression of TNF alpha mRNA in C 6 glioma cells in response to TNF alpha , interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1Ra ) , interleukin 6 ( IL 6 ) , and interferon alpha ( IFN alpha ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The adsorptive rates were 98 . 5 % for IL 1beta 98 . 0 % for interleukin 1 receptor antagonist ( IL 1RA ) , 82 . 9 % for IL 6 , 99 . 9 % for IL 8 , 31 . 2 % for TNFalpha , and 46 . 1 % for soluble TNF receptor ( sTNFr ) , respectively . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In these patients we followed the plasma concentrations of tumour necrosis factor alpha ( TNF ) , interleukin 1beta ( IL 1beta ) , IL 6 and IL 1 receptor antagonist ( IL 1Ra ) , mRNA for these cytokines in peripheral blood cells ( PBCs ) , and the lipopolysaccharide ( LPS ) stimulated ex vivo production of these cytokines in whole blood cultures ( WBCs ) . ^^^ The LPS induced ex vivo production in WBCs of TNF , IL 1beta and IL 6 decreased from 2 h post incision ; that of IL 1Ra increased . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In these patients we followed the plasma concentrations of tumour necrosis factor alpha ( TNF ) , interleukin 1beta ( IL 1beta ) , IL 6 and IL 1 receptor antagonist ( IL 1Ra ) , mRNA for these cytokines in peripheral blood cells ( PBCs ) , and the lipopolysaccharide ( LPS ) stimulated ex vivo production of these cytokines in whole blood cultures ( WBCs ) . ^^^ The LPS induced ex vivo production in WBCs of TNF , IL 1beta and IL 6 decreased from 2 h post incision ; that of IL 1Ra increased . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The conclusion drawn is that the IL 1R phenotype of LC and keratinocytes under resting conditions is consistent with the proposed contribution of IL 1beta to LC migration . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
On direct cell cell contact , stimulated T lymphocytes potently trigger the production of pro inflammatory factors such as interleukin 1beta ( IL 1beta ) and matrix metalloproteinases ( MMP 1 and MMP 9 ) , as well as anti inflammatory factors such as IL 1 receptor antagonist ( IL 1Ra ) and the tissue inhibitor of metalloproteinases ( TIMP 1 ) in peripheral blood monocytes and the monocytic cell line THP 1 . ^^^ Upon contact with T lymphocytes stimulated in the presence of 10 5 M LF , the molar ratio of IL 1Ra / IL 1beta and TIMP 1 / MMP 1 produced by THP 1 cells was enhanced 3 . 6 and 1 . 9 fold , respectively , whereas it was enhanced only 1 . 3 and 1 . 4 fold upon contact with T lymphocytes stimulated in the presence of 10 4 M DEX . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Inhalation of swine house dust increases the concentrations of interleukin 1 beta ( IL 1 beta ) and interleukin 1 receptor antagonist ( IL 1ra ) in peripheral blood . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The aim of this prospective study was to evaluate in bronchial lavage ( BL ) of patients with SA ( n = 9 ) under mechanical ventilation ( MV ) the concentrations of cytokines and related mediators which have the ability to modulate inflammation , either proinflammatory ( interleukin 1beta [ IL 1beta ] , IL 6 , tumor necrosis factor alpha [ TNF alpha ] ) , or anti inflammatory mediators ( IL 10 , transforming growth factor beta 1 [ TGF beta 1 ] ) , interleukin 1 receptor antagonist [ IL 1Ra ] , soluble TNF receptor 1 and 2 [ sTNFRI and 2 ] ) . ^^^ The ratio between IL 1Ra and IL 1beta was significantly higher in patients with SA compared with the other groups , whereas there was no difference for the ratio between both types of sTNFR and TNF alpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Expression of both the intracellular and secreted IL 1ra was detected in unstimulated and IL 1beta or phorbol 12 myristate 13 acetate exposed RPE . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
After one bolus infusion with IVIG ( 0 . 4 g / kg ) we found a significant change in the profile of the components of the IL 1 system : a marked increase in levels of IL 1 receptor antagonist ( IL 1Ra ) and neutralizing antibodies against IL 1alpha , a moderate decrease in levels of IL 1alpha , IL 1beta and soluble ( s ) IL 1 receptor type 1 and a significant increase in sIL 1 receptor type 2 levels . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Phenotype frequencies of molecularly defined HLA DR alleles , polymorphisms in the tumour necrosis factor alpha ( TNF alpha ) , lymphotoxin alpha ( LT alpha ) , IL 1 receptor antagonist ( IL 1Ra ) and IL 1beta genes were determined in 98 clinically well characterized UC patients with a mean period of follow up of 10 years , and ethnically matched healthy controls ( HC ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
It has been found that , after treating peritoneal suppressor macrophages with LPS , mRNAs of IL 12 p 35 , IL 12 p 40 , IL 6 and IFN gamma are newly appeared , while those of IL 1 alpha , IL 1 beta and IL 1Ra are increased and those of other cytokines , like TGF beta 1 and MIF are not changed at all . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Dose response and kinetics were investigated for the production of TNFalpha , IL 1beta , IL 1ra , IL 10 and IFNgamma . ^^^ LPS induces the production of TNFalpha , IL 1beta , IL 1ra and IL 10 ; PHA induces the production of IFNgamma and IL 10 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1alpha , IL 1beta and IL 1ra levels showed a model dependent shift in temporal expression . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
However , a specific IL 1RA / IL 1beta combination was associated with disease severity . ^^^ MS patients with the IL 1RA allele 2+ / IL 1beta allele 2 combination had a higher rate of progression on the Expanded Disability Status Scale when compared with the other possible combinations ( p = 0 . 007 ) . ^^^ CONCLUSIONS : IL 1RA and IL 1beta are disease severity genes rather than disease susceptibility genes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Messages encoding IL 12 , IL 10 , interferon ( IFN ) gamma , IL 1 alpha , IL 1 beta , and IL 1Ra were unaltered at all time points and doses examined . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Administration of IL 1 receptor antagonist ( IL 1ra ) to DDTC treated hLTBMCs obviated the G CSF induction profile and blocked the resultant colony proliferation , indicating that IL 1beta mediates DDTC induced G CSF release and hematopoiesis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In addition , at 2 h after injection , TNFalpha , IL 1beta converting enzyme ( ICE ) , and IL 1 receptor antagonist ( IL 1RA ) mRNAs were induced in both anterior and posterior lobes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The interleukin 1 ( IL 1 ) receptor antagonist ( IL 1ra ) is an endogenous antagonist that blocks the effects of the proinflammatory cytokines IL 1alpha and IL 1beta by occupying the type 1 IL 1 receptor . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To examine the role of IL 4 and IL 13 in production of IL 1Ra , human primary hepatocytes and HepG 2 human hepatoma cells were cultured in the presence of IL 4 or IL 13 in combination with IL 1beta and / or IL 6 . ^^^ The results indicated that both IL 4 and IL 13 amplified the stimulatory effect of IL 1beta on production of IL 1Ra protein and messenger RNA ( mRNA ) by both human primary hepatocytes and HepG 2 cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
TNF , IL 1beta , IL 1ra , IL 10 , IL 8 , MCP 1 , and MIP 1alpha levels were evaluated in supernatants of AMs incubated for 18 hours and in some cases after 4 hours of incubation . ^^^ RESULTS : Activation by IgE and anti IgE antibodies significantly increased the production of TNF , IL 1beta , IL 8 , MCP 1 , MIP lalpha , and IL 10 in both control subjects and patients with asthma , whereas the increase for IL 1ra was only significant for the control subjects . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In addition , synovial mRNA levels for IL 1 beta were decreased , while mRNA levels for IL 10 and IL 1Ra were upregulated by combined treatment . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We have studied the effect of lipopolysaccharide ( LPS ) extracted from these periodontopathogenic bacteria on synthesis of the proinflammatory cytokines , interleukin 1beta ( IL 1beta ) , tumor necrosis factor alpha ( TNF alpha ) , interleukin 6 ( IL 6 ) and the anti inflammatory cytokine IL 1 receptor antagonist ( IL 1ra ) in human whole blood . ^^^ Other in vitro and in vivo studies have , however , indicated that very large excesses ( 100 1000 times ) of IL 1ra compared to IL 1beta are required to shift the IL 1ra : IL 1beta ratio in favor of an inhibition of IL 1 bioactivity . ^^^ In our ex vivo system , we found that stimulation with extremely low doses of A . actinomycetemcomitans LPS ( 0 . 1 1 ng / ml ) resulted in IL 1ra production solely , without concomitant production of IL 1beta , the excess of IL 1ra over IL 1beta peaking at 1 ng / ml , which accordingly should suggest that LPS from A . actinomycetemcomitans primarily has proinflammatory effects . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Antibodies to interleukin 1beta ( IL 1beta ) and cytokine receptors , interleukin 1 receptor type 1 and the common gamma chain / CD132 ( gamma ) have no effect on me chanically induced membrane hyperpolarization . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We have studied whether Crohn ' s disease ( CD ) or ulcerative colitis ( UC ) is associated with certain allelic combinations of IL1B / IL1RA gene polymorphisms in a different European population than the ones studied so far . ^^^ METHODS : Ninety six patients with UC , 97 with CD , and 132 healthy individuals ( HC ) were typed for the polymorphic regions in exon 5 of the IL1B gene and in intron 2 of the IL1RA gene , using polymerase chain reaction based methods . ^^^ RESULTS : In CD homozygotes for allele 1 in IL1B gene polymorphism were more often present ( 72 % versus 28 % ; P = 0 . 01 ) in the subgroup of patients carrying at least one copy of allele 2 in IL1RA gene polymorphism . ^^^ CONCLUSIONS : Our data support the concept that CD and severe UC have a genetic disequilibrium in the distribution of IL1B and IL1RA gene polymorphisms . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : To measure the concentration of the cytokines interleukin 1beta ( IL 1beta ) , interleukin 2 ( IL 2 ) , interleukin 6 ( IL 6 ) , interleukin 10 ( IL 10 ) , and tumour necrosis factor alpha ( TNF alpha ) and the modulators of their function interleukin 1 receptor antagonist ( IL 1Ra ) , interleukin 2 soluble receptor alpha ( IL 2 sRalpha ) , interleukin 6 soluble receptor ( IL 6sR ) and soluble tumour necrosis factor receptor 1 ( sTNFR 1 ) in systemic and drained blood for the first six hours after a major orthopaedic operation . ^^^ MAIN OUTCOME MEASURE : Concentrations of IL 1beta , IL 2 , IL 6 , IL 10 , TNF alpha , IL 1Ra , IL 2 sRalpha , IL 6sR , and sTNFR 1 were measured together with haemoglobin ( Hb ) concentration , white cell count ( WCC ) , and differential count in arterial and drained blood at wound closure and 1 , 2 , 4 , and 6 hours postoperatively . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In each patient , serum levels of interleukin 1 receptor antagonist ( IL 1Ra ) , interleukin 6 ( IL 6 ) ( which represent sensitive markers of biologically active IL 1beta and tumor necrosis factor alpha levels , respectively ) , and troponin T were measured at entry and 48 hours after admission . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Whereas IL 1beta was significantly elevated throughout the study period , IL 1ra was significantly decreased from visit 1 to 3 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Increased levels of IL 1 beta and IL 1 receptor antagonist ( IL 1Ra ) have been found in serum of patients with chronic liver diseases , although their expression in liver tissue has not been extensively investigated . ^^^ The aim of this study was therefore to examine the relationship between IL 1 beta and IL 1Ra at tissue level in patients with HCV related chronic active hepatitis ( CAH ) of varying degrees of severity . ^^^ IL 1 beta and IL 1Ra mRNA expression was investigated by semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) in 31 patients with CAH of varying severity ( classified as minimal / mild in 13 cases and moderate / severe activity in 18 cases ) and in 12 control subjects . ^^^ Quantitative evaluation of IL 1 beta and IL 1Ra corresponding bands was performed by densitometric image analysis , and expressed in arbitrary units . ^^^ The 12 controls expressed a similar pattern with a mean IL 1 beta / IL 1Ra ratio of 1 . 03 ( 1 . 03 + / 0 . 15 ( mean + / s . e . m . ) , median 0 . 92 , range 0 . 71 1 . 45 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The following allelisms were analyzed : IL 1beta gene : base exchange polymorphisms at the positions 511 ( relative to the transcriptional start site ) ; IL 1alpha gene : base exchange polymorphism at the position 889 ; IL 1 receptor antagonist ( IL 1RA ) gene : variable numbers of 86 base pair tandem repeats in intron 2 . ^^^ The frequencies of the IL 1beta ( 511 ) allele 1 , IL 1alpha ( 889 ) allele 2 , and IL 1RA allele 1 were somewhat , but not significantly , higher in the schizophrenic patients as compared to the controls . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Shedding of IL 1RII yields the soluble IL 1 receptor type 2 ( IL 1sRII ) which retains the ability of membrane bound IL 1RII to bind IL 1beta avidly , but binds IL 1Ra and IL 1alpha with low affinity . ^^^ In contrast , IL 1sRI retains the ability of membrane bound IL 1RI to bind IL 1Ra and IL 1alpha with high affinity , but binds IL 1beta poorly . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Intra hypothalamic infusion of IL 1 receptor antagonist IL 1Ra ( 2 mug / rat ) prevented this effect of IL 1beta , but not that of IL 6 , suggesting an IL 1beta independent mechanism for hypothalamic 5 HT release by this latter cytokine . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present study , the levels of soluble IL 1 receptor type 2 ( sIL 1R type 2 ) , IL 1 receptor antagonist ( IL 1ra ) , IL 1beta , IL 6 and TNF alpha were analyzed in cerebrospinal fluid ( CSF ) samples from Alzheimer ' s disease patients and control subjects . ^^^ Measurements of the proinflammatory cytokines IL 6 and TNF alpha showed no significant difference between the two groups , and the levels of IL 1beta and IL 1ra in the present material were too low to permit detection . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The inflammatory cytokines interleukin 1 beta ( IL 1beta ) , interleukin 6 ( IL 6 ) , interleukin 8 ( IL 8 ) and tumour necrosis factor alpha ( TNF alpha ) and their modulators interleukin 1 receptor antagonist ( IL 1Ra ) , interleukin 6 soluble receptor ( IL 6sR ) , soluble tumour necrosis factor receptor 1 ( sTNF R 1 ) and interleukin 10 ( IL 10 ) , together with white cell count ( WCC ) and white cell differential count were measured in arterial and mixed venous blood before , during and after infusion of postoperatively drained untreated blood in nine patients operated for thoracic scoliosis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta induced chemokine production and release were inhibited by a 10 to 1 , 000 fold molar excess of recombinant IL 1RII or IL 1Ra , whereas IL 1RI was a less effective inhibitor . ^^^ Release of extracellular IL 1 inhibitors , including soluble IL 1Ra and soluble IL 1RII , by other inflammatory cells present in the airway may be critical for regulation of IL 1beta activity in the airway microenvironment . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : Cytokine content ( tumor necrosis factor alpha [ TNFalpha ] , interleukin 1beta [ IL 1beta ] , and IL 1 receptor antagonist [ IL 1Ra ] ) , at the messenger RNA ( mRNA ) and protein levels , and cell adhesion molecule expression were studied in 16 rheumatoid nodules and 6 synovial membranes . ^^^ RESULTS : Macrophages in the rheumatoid nodules contained TNFalpha , IL 1beta , and IL 1Ra mRNA and protein , particularly in perivascular cells of the stroma and in the palisading layer . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We demonstrate a depression of circulating pro inflammatory IL 1beta and an increase of circulating anti inflammatory IL 1ra during surgical stress . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The objective of this study was to evaluate the effect of diacerein , a new anti OA agent and its active metabolite , rhein , on the production and function of IL 1beta , nitric oxide ( NO ) and receptor agonist ( IL 1ra ) in human OA cartilage and synovial tissue cultures . ^^^ IL 1beta , IL 1ra , NO productions and 35S uptake were measured in culture media . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Administration of anti GRO mAb did not alter TNFalpha or IL 8 contents in SF at their peak ( 2 hours ) , but reduced the amounts of IL 1beta at 6 hours and IL 1Ra at 9 hours by 42 % and 49 % , respectively . ^^^ These results provide evidence for the following : ( a ) GRO as well as IL 8 are important mediators involved in the recruitment of neutrophils both in the early and the late phase of LPS induced arthritis , ( b ) IL 1 produced in the early phase stimulates GRO production , ( c ) GRO plays a role in the later induction of IL 1beta and IL 1Ra , and ( d ) induction of GRO is not regulated by IL 8 . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To examine the role of tumor necrosis factor alpha ( TNFalpha ) and interleukin 1 ( IL 1 ) in mediating these effects we measured MF induced expression of TNFalpha and IL 1beta mRNA in various brain regions , and the effects of TNFalpha synthesis blockers and IL 1 receptor antagonist ( IL 1ra ) on MF induced sickness behavior and adrenocortical activation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
However , treatment with IL 1beta led to a secondary sIL 1RA peak at 48 h , an effect that was substantially reversed by IL 1RA . ^^^ This stimulatory effect of IL 1beta on IL 1RA expression proved relatively specific , and nitric oxide independent , but contingent upon de novo protein biosynthesis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In contrast to IL 1alpha and IL 1beta , immunoreactive IL 1ra was readily detected in the nasal washings of normal human volunteers . ^^^ Symptomatic RV infection caused a small increase in IL 1alpha , a modest increase in IL 1beta , and an impressive increase in IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : To test if interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1Ra ) , IL 4 , or IL 10 gene polymorphisms could be used as markers of susceptibility or severity in rheumatoid arthritis ( RA ) . ^^^ From genomic DNA , 6 polymorphisms in genes for IL 1beta , IL 1Ra , IL 10 , and IL 4 were typed . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To gain further insight into the intraovarian IL 1 hypothesis , we studied the cellular localization cyclic variation and hormonal regulation of IL 1beta , as well as of the type 1 and type 2 IL 1 receptors ( IL 1R ) in immature rats . ^^^ In situ hybridization localized IL 1beta and type 1 IL 1R transcripts to the granulosa cell compartment , the innermost layers of the theca interna and to the oocyte of the untreated immature ovary . ^^^ Molecular probing of whole ovarian material in the course of a simulated estrous cycle revealed a progressive preovulatory increase in IL 1beta and type 1 IL 1R transcripts to an in vivo peak at the time of ovulation ( 3 . 0 and 2 . 5 fold increases over untreated controls ; P < 0 . 05 ) . ^^^ The basal in vitro expression pattern of IL 1beta and type 2 IL 1R transcripts by whole ovarian dispersates revealed an early ( 4 h ) spontaneous increase to a peak ( 2 . 1 and 5 . 8 fold increases over time 0 : P < 0 . 05 ) followed by a gradual decline to a 48 h nadir . ^^^ Treatment of whole ovarian dispersates with the IL 1 receptor antagonist ( IL 1RA ) or with IL 1beta failed to alter the initial ( 4 h ) burst of IL 1beta or of type 2 IL 1R expression thereby suggesting IL 1 independence . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : To determine the relationship between the antiinflammatory molecule interleukin 10 ( IL 10 ) and disease symptoms , IL 1beta , tumor necrosis factor ( TNF ) , and IL 1 receptor antagonist ( IL 1ra ) in patients with polymyalgia rheumatica ( PMR ) . ^^^ IL 10 , IL 1beta , TNF , and IL 1ra were measured in all patients and 31 age matched healthy controls by enzyme immunometric assays . ^^^ In these patients , elevated serum levels of IL 10 were positively associated with an increased ratio of IL 1ra to IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We used specific and highly sensitive RNase protection assays to determine mRNA changes for IL 1beta , IL 1 receptor type 1 ( IL 1RI ) , IL 1R accessory proteins 1 and 2 ( IL 1R AcP 1 and 2 ) , IL 1 receptor antagonist ( IL 1Ra ) , transforming growth factor beta 1 ( TGF beta 1 ) , glycoprotein 130 ( gp 130 ) , leptin receptor ( OB R ) , neuropeptide Y ( NPY ) and pro opiomelanocortin ( POMC ) in the cerebellum , parieto frontal cortex , hippocampus , hypothalamus , and midbrain of male young ( 3 5 months ) and old ( 24 26 months ) Long Evans rats . ^^^ In both young and old rats , IL 1beta induced a significant up regulation of cerebellar IL 1Ra , IL 1RI , and TGF beta 1 mRNAs ; hippocampal TGF beta 1 mRNA ; hypothalamic IL 1beta , IL 1Ra , TGF beta 1 , and gp 130 mRNAs ; and midbrain IL 1beta and TGF beta 1 mRNAs . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The molar ratio of IL 1Ra / IL 1beta induced by M . tuberculosis was markedly higher in IL 1Ra A 2 ( + ) individuals ( P < 0 . 05 ) , with minor overlap between the groups , reflecting linkage between the IL 1Ra A 2 and IL 1beta ( +3953 ) A 2 alleles . ^^^ In M . tuberculosis stimulated peripheral blood mononuclear cells , the addition of IL 4 increased IL 1Ra secretion , whereas interferon gamma increased and IL 10 decreased IL 1beta production , indicative of a differential influence on the IL 1Ra / IL 1beta ratio by cytokines . ^^^ In a study of 114 healthy purified protein derivative reactive subjects and 89 patients with tuberculosis , the frequency of allelic variants at two positions ( 511 and +3953 ) in the IL 1beta and IL 1Ra genes did not differ between the groups . ^^^ However , the proinflammatory IL 1Ra A 2 ( ) / IL 1beta ( +3953 ) A 1 ( + ) haplotype was unevenly distributed , being more common in patients with tuberculous pleurisy ( 92 % ) in comparison with healthy M . tuberculosis sensitized control subjects or patients with other disease forms ( 57 % , P = 0 . 028 and 56 % , P = 0 . 024 , respectively ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To further investigate the effects of A beta phagocyte interaction , we examined the production of proinflammatory ( IL 1beta , IL 6 ) , chemotactic ( MIP 1alpha , IP 10 ) and inhibitory ( IL 1Ra , IL 10 and TGFbeta 1 ) cytokines by cultured human monocytes and mouse microglial cells upon stimulation with A beta [ 25 35 ] . ^^^ Northern blot analysis and specific immunoassays demonstrated that A beta [ 25 35 ] triggers mRNA expression and release of IL 1beta , IL 1Ra and MIP 1alpha but not of IL 6 , IL 10 , TGFbeta 1 and IP 10 from human monocytes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Aspirin had minor effects on ex vivo secretion of IL 1beta and no influence on IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In contrast , soluble receptors of TNF ( type 1 and 2 ) and of IL 6 , and IL 1beta receptor antagonist ( IL 1ra ) were increased in CI and CLI patients , as compared to C . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To investigate whether circulating leptin is related to cytokine release and survival in human sepsis , plasma concentrations of leptin , interleukin ( IL ) 6 , IL 1beta , tumor necrosis factor ( TNF ) alpha , soluble TNF receptor type 1 , IL 1 receptor antagonist ( IL 1ra ) , and the inflammatory modulator IL 10 were measured as soon as severe sepsis ( n=28 ) or septic shock ( n=14 ) developed and every 6 h for 24 h . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
PDTC ( 100 microM ) completely abrogated LPS induced kappaB binding activity and also profoundly inhibited the induction of interleukin 1alpha ( IL 1alpha ) , IL 1beta , IL 6 , IL 10 , granulocyte colony stimulating factor , granulocyte macrophage colony stimulating factor , and MCP 1 and , to a lesser extent , leukemia inhibitory factor , RANTES , and IL 1Ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Levels of interleukin 1beta ( IL 1beta ) , interleukin 1 receptor antagonist ( IL 1Ra ) , interleukin 6 ( IL 6 ) , tumor necrosis factor alpha ( TNF alpha ) , and soluble interleukin 2 receptor ( sIL 2R ) in GD patients were significantly higher than in normal controls . ^^^ Type 1 GD patients with more severe clinical manifestations had significantly higher levels of IL 1beta , IL 1Ra and IL 6 , relative to type 1 patients with milder disease . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The pregnancies of 58 healthy adolescents ( ages 13 to 19 years ) were followed to examine links between symptoms of depression , corticotropin releasing hormone ( CRH ) , interleukin 1 beta , ( IL 1 beta ) , and IL 1 receptor antagonist ( IL 1ra ) as possible predictors of maternal and infant outcomes . ^^^ Plasma samples collected during gestation were assayed for CRH , IL 1 beta , and IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta on the release of the IL 1 receptor antagonist ( IL 1ra ) were studied in parallel . ^^^ IL 1beta stimulated IL 6 and IL 1ra release into peripheral blood , the stimulation was much more profound after i . c . v . injection ( p < 0 . 001 ) . ^^^ IL 1beta vs . 224 + / 190 pg / ml after i . c . v . saline injection ; IL 1ra was 47 , 460 + / 6290 pg / ml vs . 1040 + / 550 pg / ml . ^^^ Thus , in the monkey , i . c . v . injection of IL 1beta stimulates the release of large amounts of IL 6 and IL 1ra into the CSF and the peripheral circulation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The presence of IL 1Ra or antisense ICE also suppressed the endogenous IL 1 beta production of AML cells , at both the level of pro IL 1 beta and mature IL 1 beta . ^^^ Although inhibition by IL 1Ra or antisense ICE on growth parameters of AML cells in vitro prevailed , indicating the importance of IL 1 activity in autonomous AML cell growth , stimulatory effects on the cells of some patients suggest that AML is a heterogenous disorder regarding IL 1 beta regulation . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To assess the potential role of these cytokines , we tested the ability of the naturally occurring IL 1 receptor antagonist ( IL 1ra ) , a monoclonal antibody to mouse IL 6 ( IL 6mAb ) , and a TNF binding protein fragment ( TNFbp ) to antagonize hypophagia induced by intraperitoneally ( ip ) injected mouse IL 1beta or LPS or by inoculation with influenza virus . ^^^ The effects of IL 1beta were blocked by IL 1ra but unaffected by TNFbp . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Two hours , the effect of LPS on ACTH output was not modified by pretreatment with anti IL 1beta IgG , anti IL 6 IgG , anti TNF alpha IgG nor with IL 1ra , although IL 1ra treatment was able to fully block the IL 1beta ( 35 microg / kg body weight ) stimulated HPA axis function , 1 and 2 h after cytokine administration . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The ELISA was sensitive to 10 pg . ml 1 rat TNF alpha and was specific for TNF alpha , showing no cross reactivity with rat IL 1alpha , rat IL 1beta , rat IL 1Ra or rat IL 6 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Thus , amphotericin B induces gene expression for IL 1beta , TNF alpha , and IL 1Ra in human and murine monocytic cells . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We demonstrate that adenoviral gene delivery of the cDNA encoding the interleukin 1 receptor antagonist protein ( IL 1Ra ) to cultured islets results in protection of human islets in vitro against IL 1beta induced nitric oxide formation , impairment in glucose stimulated insulin production , and Fas triggered apoptosis activation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Here , we report on the levels of interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1Ra ) , tumor necrosis factor alpha ( TNF alpha ) , transforming growth factor beta 1 ( TGF beta 1 ) , IL 1 receptor type 1 ( IL 1RI ) , IL 1 receptor accessory protein ( IL 1R AcP ) 1 and 2 , glycoprotein 130 , and various neuropeptide mRNAs in the cerebellum , parieto frontal cortex , hippocampus and hypothalamus of BDV infected rats at 7 and 28 days postintracerebral BDV inoculation . ^^^ The same cerebellar samples from BDV infected animals exhibited the highest levels of IL 1beta , IL 1Ra , TNF alpha , IL 1RI , and IL 1R AcP 2 mRNA expression . ^^^ The profiles of IL 1beta , IL 1Ra , TNF alpha , and TGF beta 1 mRNA induction in the cerebellar samples were highly intercorrelated , indicating an association among cytokine ligand mRNAs . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The concentrations of cytokines ( interleukin [ IL ] 1 alpha , IL 1 beta , IL 1 receptor antagonist [ IL 1ra ] , IL 6 , and tumor necrosis factor alpha [ TNF alpha ] ) within maternal and fetal tissue homogenates were determined by enzyme linked immunosorbent assay at various times after inoculation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Extended studies demonstrated that naive ASM exposed to exogenously administered IL 5 exhibited an induced upregulated mRNA expression and protein release of IL 1beta associated with proasthmatic like changes in ASM constrictor and relaxant responsiveness , and that these effects were ablated in tissues pretreated with IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Overexpression of IL 1ra gene up regulates interleukin 1beta converting enzyme ( ICE ) gene expression : possible mechanism underlying IL 1beta resistance of cancer cells . ^^^ Treatment with either IL 1ra ( 100 ng ml ( 1 ) ) , IL 1beta antibody ( 100 microg ml ( 1 ) ) , or YVAD CHO blocked AxlL 1ra induced cell death in KU 19 19 and KU 19 20 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
With the use of RNase protection assays , we measured mRNA levels of interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1RA ) , IL 1 receptor type 1 ( IL 1RI ) , IL 1R accessory proteins ( AcP 1 and 2 ) , tumor necrosis factor alpha ( TNF alpha ) , transforming growth factor beta 1 ( TGF beta 1 ) , glycoprotein 130 ( Gp 130 ) , leptin receptor ( OB R ) , neuropeptide Y ( NPY ) , preprodynorphin , and proopiomelanocortin ( POMC ) . ^^^ The data show that food deprivation increases the basal mRNA expression of IL 1beta , IL 1RA , TNF alpha , IL 1RI , and IL 1R AcP 1 , whereas mRNA levels of POMC showed a decrease . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We investigated lipopolysaccharide ( LPS ) and adherent IgG stimulated release of IL 1beta , IL 1 receptor antagonist ( IL 1ra ) and IL 10 , a potent modulator of IL 1 , by blood mononuclear cells from patients with SLE . ^^^ LPS stimulated IL 1ra release was normal and the IL 1ra / IL 1beta ratio was therefore increased ( P < 0 . 05 ) and correlated inversely to prednisolone dosage ( P = 0 . 009 ) . ^^^ We conclude that monocytes from patients with active SLE are deficient in Fc gamma R mediated production of IL 1ra , whereas LPS stimulated IL 1beta release by SLE monocytes is reduced regardless of disease activity . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Whole blood production of monocytic cytokines ( IL 1beta , IL 6 , TNF alpha , sIL 6R , IL 1Ra ) in haemodialysed patients . ^^^ Supernatants were collected after 24 and 48 h of culture , and concentrations of IL 1 beta , IL 6 , TNF alpha , sIL 6R and IL 1Ra were determined by ELISA . ^^^ Despite a similar significant LPS and PHA induced production of IL 1Ra , the IL 1Ra / IL 1beta ratio was always higher in patients than in controls . ^^^ Higher sIL 6R / IL 6 and IL 1Ra / IL 1beta ratios could also participate to the complex immune disturbances of HD patients by reducing the biological activity of two cytokines playing a major role in the immune and inflammatory network . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Within grafts at day 3 , there was a 3 fold reduction in IL 1beta expression and a 4 fold reduction in IL 1RA in iNOS ( / ) recipients ( p = 0 . 03 andp = 0 . 04 , respectively ) compared to wild type recipients . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
This study investigated the inflammatory effect of IL 1beta during transient focal cerebral ischemia and reperfusion in the mouse transduced with the interleukin 1 receptor antagonist ( IL 1ra ) gene . ^^^ Our studies demonstrated that overexpression of IL 1ra in the mouse brain can downregulate intracellular adhesion molecule 1 expression both in the cortex and basal ganglia , which suggests that IL 1beta may play an important role in the activation of the inflammatory response during focal cerebral ischemia by promoting leukocyte adhesion to endothelial cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Paradoxically , administration of IDN 1529 but not IDN 1965 led to an increase in the LPS induced elevation of serum cytokines related directly ( IL 1beta , IL 18 ) or indirectly ( IL 1alpha , IL 1Ra ) to the action of caspase 1 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : We examined the IL 17 induced NO production in human OA chondrocytes , in combination with the proinflammatory cytokines IL 1beta , tumor necrosis factor alpha ( TNF alpha ) , and leukemia inhibitory factor ( LIF ) ; the antiinflammatory cytokines IL 4 , IL 10 , and IL 13 ; and IL 1 receptor antagonist ( IL 1Ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Expression of IL 1alpha and beta , IL 1 receptor antagonist ( IL 1Ra ) , IL 1RI and 2 , IL 1R accessory protein ( IL 1RAcP ) and IL 1beta converting enzyme ( ICE ) was studied by immunocytochemistry , immunoblotting , ELISA and RT PCR . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
DCs , unlike B cells , were induced to increase expression of IL 1beta , IL 1Ra , IL 8 , IL 12 p 40 , RANTES , macrophage inflammatory protein 1alpha , and monocyte chemoattractant protein 1 after CD 40 ligation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RNase mapping analysis indicated that IL 1alpha , IL 1beta , IL 1Ra , and IL 6 mRNA levels are constitutively elevated in thioglycolate elicited IkappaBepsilon null macrophages in contrast to GM CSF , G CSF , and IFN gamma , which remain undetectable . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
During the first 4 hours of infection in a rabbit ligated loop model of intestinal invasion , there are two salient characteristics : ( 1 ) a high concentration of IL 1alpha and IL 1beta , both in infected Peyer ' s patch tissue and in the corresponding efferent mesenteric blood , and ( 2 ) a very low level of expression of IL 1 receptor antagonist ( IL 1ra ) . ^^^ These may reflect a combination of regulation of expression and secretion of IL 1alpha , IL 1beta , and IL 1ra by both resident and recruited phagocytes and the induction of mononuclear phagocyte apoptosis by Shigella . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The effect of IL 1beta was Ca ( 2+ ) dependent and significantly inhibited by 100 ng / ml IL 1 receptor specific antagonist ( IL 1r antagonist ) , cyclooxygenase ( COX ) inhibitors such as 0 . 1 mM aspirin , 1 microg / ml indomethacin , and 1 microM NS 398 ( specific for COX 2 ) , and 1 microM dexamethasone . ^^^ Furthermore , a 1 h incubation with IL 1beta markedly increased the inducible COX 2 mRNA level , which was inhibited by an IL 1r antagonist and dexamethasone , whereas IL 1beta showed no effect on the level of constitutive COX 1 mRNA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
ELF levels of TNF alpha , soluble ( s ) TNF receptor 1 ( RI ) , sTNF receptor 2 ( RII ) and interleukin 1 receptor antagonist ( IL 1RA ) but not IL 1beta , and their serum levels except for sTNF RII and IL 1beta were significantly higher in TB patients . ^^^ No correlation was found between TNF alpha levels and those of sTNF RI and sTNF RII , nor between IL 1beta and IL 1RA in ELF and serum of TB patients , although there was a significant correlation between sTNF RI and sTNF RII levels both in ELF and serum . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Elevated production of cytokines such as TNF alpha and IL 1beta and reduced IL 1ra may contribute to enhanced replication of HIV 1 in bystander T cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The stimulatory effect of IL 1beta was reduced by IL 1 receptor antagonist ( IL 1Ra ) in a dose dependent manner . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Circulating concentrations and lipopolysaccharide ( LPS ) or phytohaemagglutinin ( PHA ) stimulated whole blood production of the proinflammatory cytokines IL 1beta , IL 1ra , tumour necrosis factor alpha ( TNF alpha ) and IL 10 and IFN gamma were measured . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Clodronate LIP treatment prevented allograft rejection and strongly decreased the levels of IL 1beta , IL 1RA , IL 2 , IL 4 , IL 6 , IL 10 , IFN gamma , TNF beta / LT , MCP 1 , and MIP 2 mRNA in grafts and IL 1 beta , IL 2 , IL 4 , IL 6 , and IFN gamma mRNA in rims . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The shape change and subsequent repair processes are IL 1beta activity dependent , acting through the IL 1 type 1 receptor ( IL 1R1 ) , as co application of the IL 1type 1 receptor antagonist protein ( IL 1ra ) blocks IL 1beta induced effects . ^^^ Cells were treated with IL 1beta and / or IL 1ra , followed by measurement of relative changes in [ Ca2+ ] 1 using fura 2 fluorescence imaging methods . ^^^ Treatment with IL 1ra blocked IL 1beta induced increases in [ Ca2+ ] 1 , indicating that IL 1beta acts through the IL 1R1 . ^^^ Immunocytochemistry experiments showed that untreated C 6 cells normally express IL 1beta , IL 1ra , and IL 1RI . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The results indicate that IL 1ra at doses more than adequate to prevent responses to exogenously administered IL 1beta , failed to significantly attenuate the increases in plasma ACTH and corticosterone and the cerebral catecholamine and indoleamine responses induced by intraperitoneal LPS in mice . ^^^ Intracerebroventricular administration of IL 1ra attenuated the endocrine and neurochemical responses to intraperitoneal IL 1beta . ^^^ However , intracerebroventricular IL 1ra failed to antagonize the HPA and neurochemical responses to intraperitoneal administration of LPS or to intravenous IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Moreover , pro inflammatory cytokines like IL 1 beta and tumor necrosis factor alpha ( TNF alpha ) play a major role in chronic inflammatory pathologies being IL 1ra and TNF alpha soluble receptors , natural counterbalancing inhibitors . ^^^ In light of this background , we decided to measure serum levels of IL 1 beta , IL 1ra , TNF alpha and IL 6 in LL and TL patients , and we also studied the production in vitro of Th 1 ( IFN gamma , IL 2 ) , Th 2 ( IL 4 , IL 10 ) and TNF alpha cytokines . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Levels of tumor necrosis factor alpha ( TNFalpha ) , TNF soluble receptor ( sTNFRI and 2 ) , interleukin 1 beta ( IL 1beta ) , and IL 1 receptor antagonist ( IL 1Ra ) in the supernatants of URO stimulated PBMC were measured by ELISA . ^^^ Peak levels of TNFalpha and IL 1beta were reached at 6 12 h , while 5 10 fold higher in sTNFR 2 and IL 1Ra levels were observed at 24 48 h after URO stimulation . ^^^ URO induced secretion of TNFalpha , IL 1beta , sTNFRII and IL 1Ra could be enhanced by human plasma . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
At the conclusion of the culture period , total RNA was extracted and probed for transcripts corresponding to PGS 1 , PGS 2 , IL 1beta , IL 1 receptor antagonist ( IL 1RA ) or type 1 IL 1 receptor ( IL 1R ) by a solution hybridization / ribonuclease protection assay . ^^^ The upregulation by IL 1 of IL 1beta , IL 1R and IL 1RA transcripts was similarly inhibited by indomethacin . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Release of IL 1beta , and the two antagonists , IL 1 receptor antagonist ( IL 1ra ) and IL 10 from blood mononuclear cells were therefore quantitated by ELISA in 22 patients with RA , 11 with non RA and 15 healthy age matched controls . ^^^ The ratio of IL 1ra / IL 1beta was elevated in LPS stimulated cells from RA patients only : 2 . 0 versus 1 . 3 ( P=0 . 02 ) . ^^^ In conclusion , increased IgG stimulated IL 1ra release and elevated IL 1ra / IL 1beta ratio may protect against actions of IL 1 in vivo , and decreased release of IL 10 might be related to features of non erosive arthritis . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The novel genes demonstrate significant sequence similarity to IL 1alpha , IL 1beta , IL 1ra , and IL 18 , and in addition maintain a conserved exon intron arrangement that is shared with the previously known members of the family . ^^^ Protein structure modeling also suggests that the FIL 1 genes are related to IL 1beta and IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVES : We investigated the possibility that the large pulmonary cavity in tuberculosis ( TB ) lesions might result from imbalances between tumor necrosis factor alpha ( TNF alpha ) and soluble TNF alpha receptor forms ( sTNF RI and sTNF RII ) , and interleukin beta ( IL 1beta ) and IL 1 receptor antagonist ( IL 1RA ) in sites of local inflammation . ^^^ PATIENTS AND METHODS : BAL was performed in 32 patients with active pulmonary TB , and the recovered BAL fluid ( BALF ) was examined for concentrations of TNF alpha and its soluble receptor forms , IL 1beta , and IL 1RA . ^^^ RESULTS : The concentrations of TNF alpha , IL 1beta , and IL 1RA in BALF were significantly higher in group 1 patients than in group 2 patients before standardization . ^^^ Furthermore , group 1 patients had significantly higher ratios of TNF alpha to sTNF RI and sTNF RII and IL 1beta to IL 1RA compared with group 2 patients . ^^^ CONCLUSIONS : These findings suggest that the relative abundance of TNF alpha and IL 1beta associated with imbalances of secretion of soluble TNF alpha receptor forms and IL 1RA may have caused tissue necrosis leading to cavity formation in patients with active pulmonary TB . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Proinflammatory cytokines such as IL 1beta , IL 6 , and tumor necrosis factor alpha were overexpressed in the joints , indicating regulatory roles of IL 1ra in the cytokine network . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
DESIGN : Single base change polymorphisms in interleukin 1 beta ( IL 1 beta ) , interleukin 10 ( IL 10 ) and fucosyltransferase 2 ( FUT 2 ) , microsatellite polymorphisms in interleukin 1 alpha ( IL 1 alpha ) and IL 10 and a minisatellite polymorphism in interleukin 1 receptor antagonist ( IL1RA ) were typed in over 400 tuberculosis cases and 400 healthy blood donor controls . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 receptor antagonist ( IL 1Ra , an endogenous inhibitor that blocks IL 1alpha and IL 1beta actions ) mRNA was not upregulated . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
BACKGROUND : Soluble tumor necrosis factor receptor ( sTNFr ) and interleukin 1 receptor antagonist ( IL 1ra ) have been identified as endogenous inhibitors of TNF alpha and IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Secretion of IL 1beta , IL 6 , IL 8 , and IL 1ra was measured by enzyme linked immunosorbent assay . ^^^ Transcripts encoding IL 1beta , IL 1ra , IL 6 , and IL 8 were identified in LPMNC preparations of all specimens . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We measured cytokine mRNA ( IL 1beta , IL 1ra , IL 6 , and TNF alpha ) directly in bone biopsies from early postmenopausal women to determine if a lower compensatory increase in IL 1ra mRNA could be demonstrated in women with rapid bone loss after the menopause . ^^^ The IL 1ra / IL 1beta mRNA slope for the slow loss group was steeper ( deltaF = 23 . 3 , p < 0 . 01 ) than that observed in the fast loss group , indicating that slower bone loss was associated with higher IL 1ra mRNA levels relative to IL 1beta . ^^^ Histomorphometric analysis revealed weak correlations between IL 1beta mRNA and activation frequency ( r 2 = 0 . 26 , p = 0 . 06 ) and between IL 1ra and volume referent bone resorption rate ( r 2 = 0 . 19 , p = 0 . 11 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Furthermore , the levels of IL 1beta , IL 6 , and IL 1ra in Pa immunized IL 4 ( / ) mice were comparable to those in mice immunized with Pw . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Following amygdala kindling in rats , we determined alterations of IL 1beta , IL 1 receptor antagonist ( IL 1Ra ) , IL 1 receptor type 1 ( IL 1RI ) , IL 1 receptor accessory proteins ( IL 1R AcPs ) 1 and 2 , TNF alpha , TGF beta 1 , neuropeptide Y ( NPY ) , glycoprotein 130 ( gp 130 ) and pro opiomelanocortin ( POMC ) mRNA levels in the parietal , prefrontal and piriform cortices , amygdala , hippocampus and hypothalamus . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : We performed an immunohistochemical study of DRA tissues ( 8 cases ) to confirm the existence of TGF betas and their receptors ; we also performed a chemotaxis assay of human monocytes as well as enzyme linked immunosorbent assay ( ELISA ) of TGF beta 1 , tumor necrosis factor alpha ( TNF alpha ) , interleukin 1beta ( IL 1beta ) , and interleukin 1 receptor antagonist ( IL 1Ra ) in the supernatant of human monocyte derived macrophage cell culture under varying conditions of incubation with TGF beta 1 , AGE beta2m , and TGF beta 1 antibody additions . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We also show that T ( h ) 1 cells but not T ( h ) 2 cells have increased expression of IL 18R and IL 1R , and produce IFN gamma in response to IL 18 and / or IL 1beta . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Blockade of the CD 40 CD40 ligand interaction resulted in inhibition of IL 1beta inducing capacity while IL 1Ra induction was unaffected , a result previously unknown . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta , IL 12 and IL 1ra were evaluated by ELISA . ^^^ The amounts of IL 1beta , IL 12 and IL 1ra detected in our uveitis patients correlated with levels of MMP 2 ( p < 0 . 07 , p < 0 . 0004 , p < 0 . 03 ) and MMP 9 ( p < 0 . 003 , p < 0 . 0001 , p < 0 . 002 ) , and IL 12 ( p < 0 . 004 , p < 0 . 0001 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Exposure or non exposure to an embryo did not result in differing levels of IL 1alpha , IL 1beta , or IL 1ra in the CM . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The interleukin 1 ( IL 1 ) family consists of two agonist proteins , IL 1 alpha and IL 1 beta , and one antagonist , IL 1 receptor antagonist ( IL 1ra ) , which blocks the action of the agonists by binding and competing at the IL 1 receptor level . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the presence of an IL 1 receptor antagonist ( IL 1ra ) , IL 1beta did not activate nSMase either in the cortex of wild type or knock out mice . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Our data clearly demonstrated that in LPS treated macrophages , cAMP elevator ( CTx and 8 bromo cAMP ) could increase IL 1Ra and IL 10 gene expression , while mRNAs of IL 1alpha , IL 12 , IL 6 , and MIF were decreased and other cytokines like IL 1beta , and IFN gamma did not give a definite tendency . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We find that in Abeta stimulated astrocyte cultures , IL 1beta and TNFalpha production occur before iNOS production , new protein synthesis is required for increased iNOS mRNA levels , and the IL 1 receptor antagonist IL 1ra can inhibit nitrite accumulation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The aim of the present study was to quantitate the temporal changes in protein concentration for interleukin ( IL ) 1alpha , IL 1beta , IL 1ra , and IL 6 from 1 h to 15 days following focal ischemia . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present study , we have analyzed the temporal profile of the expression of the cytokines interleukin 1beta ( IL 1beta ) and IL 1 receptor antagonist ( IL 1ra ) , and the related IL 1beta converting enzyme ( ICE / caspase 1 ) , in different regions of the rat brain in response to peripheral kainic acid administration ( 10 mg / kg , i . p . ) . ^^^ In conclusion , in response to systemic kainic acid injection IL 1beta mRNA is rapidly induced and followed by induction of IL 1ra mRNA and caspase 1 mRNA , supporting a role of the IL 1 system in the inflammatory response during excitotoxic damage . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 receptor antagonist ( IL 1ra ) is a competitive inhibitor of IL 1beta effects and the biological effects of IL 1beta are therefore proportional to the ratio IL 1beta / IL 1ra . ^^^ Other polymorphisms in the IL 1ra and the IL 1beta genes are not associated with osteoporotic fractures or alterations in bone mass or bone turnover . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Central gp 120 administration also caused increases in IL 1beta protein levels in the hippocampus and frontal cortex but not in the hypothalamus . gp 120 induced memory impairments were blocked by 2 different IL 1 antagonists , alpha melanocyte stimulating hormone ( alphaMSH ) and interleukin 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The studies presented herein show that a broad spectrum of antimalarial drugs augmented the replication of SFV in mice , concomitant with greater tissue damage and up regulation of mRNA levels of various inflammatory cytokine genes , including interleukin 1 receptor antagonist ( IL 1Ra ) , 2 1alpha , IL 1beta , IL 6 , IL 12p40 , and interferon gamma inducing factor . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
CD11c+ cells responded to LPS stimulation by producing high levels of interleukin 1beta ( IL 1beta ) and tumor necrosis factor alpha ( TNF alpha ) , and lower levels of IL 6 , IL 1Ra , and IL 8 and an increased expression of accessory molecules ( CD 25 , CD 40 , CD 80 , CD 86 , HLA DR , and HLA DQ ) . ^^^ PMA+I activation of CD11c+ cells resulted in high levels of IL 1beta and lower levels of IL 8 , IL 1Ra , and TNF alpha and up regulation of CD 80 , CD 86 , HLA DR , and HLA DQ . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Our present study investigated the expression of IL 1beta , IL 1 receptor antagonist ( IL 1ra ) , and IL 1 receptor ( IL 1RI and IL 1RII ) mRNA in carotid artery after balloon angioplasty using semiquantitative reverse transcription / polymerase chain reaction ( RT / PCR ) and Northern analysis . ^^^ The differential but concomitant expression of IL 1beta , IL 1ra , IL 1RI , and IL 1RII mRNAs after balloon angioplasty suggests that each of these IL 1 system components may play a distinct role in neointima formation . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Smoking and GCF levels of IL 1beta and IL 1ra in periodontal disease . ^^^ AIMS : GCF levels of the cytokine IL 1beta and its receptor antagonist IL 1ra were analyzed with respect to smoking in patients with moderate to severe periodontal disease . ^^^ IL 1beta , IL 1ra , IgA and IgG were determined with immunoelectrophoresis . ^^^ IL 1beta was detected in GCF of 95 % of both smokers and non smokers and IL 1ra in all patients . ^^^ The GCF level of IL 1ra was approximately 1 , 000 fold that of IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Polymorphisms within the IL 1beta and the IL 1RA genes ( located on chromosome 2 ) are associated with altered protein production rates , and certain haplotypes have been linked to inflammatory disease ( no studies in bacterial infectious disease have been published ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Increased IL 1ra expression did not clearly affect other cytokine profiles ( IL 1beta , IFN gamma , IL 2 ) , except for an increase of IL 10 on day eight . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Serum levels of C reactive protein ( CRP ) , interleukin 1beta ( IL 1beta ) , interleukin 1 receptor antagonist ( IL 1RA ) , interleukin 6 ( IL 6 ) , tumor necrosis factor alpha ( TNF alpha ) , soluble interleukin 6 receptor ( sIL 6R , gp 80 ) , soluble tumor necrosis factor receptor 2 ( sTNFRII , p 75 ) , COMP and MIA were measured by ELISA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We studied the putative association of a C > T polymorphism in exon 5 of IL 1beta and an 85 bp tandem repeat in intron 4 of IL 1 receptor antagonist ( IL 1ra ) genes with susceptibility to or outcome of MS . ^^^ Allele 2 of IL 1beta and allele 3 of the IL 1ra polymorphisms were associated with a favorable outcome ( P=0 . 023 and P=0 . 030 ) . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
SCF , IL 1beta , IL 1ra and GM CSF in the bone marrow and serum of normal individuals and of AML and CML patients . ^^^ AML differed from normal in that : ( 1 ) AML marrow cells contain more IL 1beta protein than normal cells , ( 2 ) IL 1ra transcripts are absent from AML marrow cells , ( 3 ) AML marrow serum contains less IL 1ra protein than normal , ( 4 ) peripheral blood and marrow serum of AML patireents contains more SCF protein than normal serum , and ( 5 ) SCF transcripts have been detected in AML marrow biopsies and not in aspirate cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Pretreatment with an IL 1 receptor antagonist ( IL 1ra , 16 mg / kg , i . p . ) completely blocked the suppression of food intake produced by injection of IL 1beta ( 4 microg / kg , i . p . ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1alpha ( IL 1alpha ) and IL 1beta , and the endogenous IL 1 receptor antagonist ( IL 1ra ) are known members of the IL 1 family . ^^^ In addition , IL 1ra mRNA expressing cells were observed scattered in the brain parenchyma , whereas scattered IL 1beta mRNA expressing cells were restricted to central thalamic nuclei , the dorsal hypothalamus , and cortical regions , such as the parietal and frontal cortex . ^^^ The cell types expressing the mRNA ' s of IL 1alpha , IL 1beta and IL 1ra were identified as monocytes in the circumventricular organs and the pituitary gland , and as microglia in the brain parenchyma . ^^^ IL 1beta is the predominant form expressed , whereas the expression of IL 1alpha mRNA and IL 1ra mRNA is lower . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
For detection of cytokines , interleukin ( IL ) 1alpha , IL 1beta , IL 6 , macrophage colony stimulating factor ( M CSF ) , granulocyte colony stimulating factor , and TNF alpha were measured in serum by enzyme linked immunosorbent assays , as were soluble ( s ) IL 1 receptor antagonist ( IL 1ra ) , sIL 6R , p55sTNF R , and p75sTNF R . ^^^ RESULTS : IL 1alpha , IL 1beta , IL 6 , and TNF alpha were not detected , and sIL 6R and IL 1ra concentrations were not significantly different between the three age groups . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
ANP significantly attenuated production of TNF alpha and IL 1beta without affecting production of IL 10 and IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We wanted to evaluate the clinical relevance of interleukin ( IL ) 6 , IL 1 beta and interleukin 1 receptor antagonist ( IL 1Ra ) in B CLL . ^^^ As the plasma levels of IL 6 , IL 1 beta and IL 1Ra have been suggested to be partly dependent on gene polymorphism , the previously described polymorphisms of the IL 1 complex genes and the IL 6 gene were also studied . ^^^ RESULTS : The plasma concentrations of IL 1 beta and IL 1Ra were lower in B CLL patients than in normal controls ( p < 0 . 001 ) . ^^^ INTERPRETATION AND CONCLUSIONS : Our data demonstrate that in B CLL , plasma levels of IL 1 beta , IL 1Ra and IL 6 differ from normal , and mechanisms other than allelic imbalance of their genes account for the distinct cytokine profiles observed in this disease . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The amounts of induced IL 1ra were equal or higher than those obtained using other IL 1ra stimuli ( LPS , IL 1beta , IFNgamma , IL 4 , dexamethasone ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The ability of hypoxic ACM to up regulate inflammatory genes in HCECs was inhibited in the presence of IL 1 receptor antagonist ( IL 1Ra ) and by pretreating ACM with the blocking anti IL 1beta antibody . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The antagonist peptide binds to the domain 1 / 2 junction of the receptor , which is a conserved binding site for IL 1beta and IL 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We have measured the plasma levels IL 1 beta of 400 healthy blood donors and correlated these to the genotype ( biallelelic base exchanges at the position 889 of the IL 1 alpha gene , and at the position 511 of the IL 1 beta gene and the pentaallelic VNTR in the second intron of the IL 1Ra gene ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The effect of IL 1ra on response to intraplantar ( i . pl . ) injection of LPS , carrageenin , bradykinin , TNFalpha , IL 1beta , IL 8 , PGE ( 2 ) and dopamine was investigated in a model of mechanical hyperalgesia in rats . 2 . ^^^ IL 1ra inhibited hyperalgesic response to LPS , carrageenin , bradykinin , TNFalpha , and IL 1beta , but not responses to IL 8 , PGE ( 2 ) and dopamine . 3 . ^^^ A sheep anti rat IL 1ra serum potentiated response to LPS , carrageenin , bradykinin , TNFalpha and IL 1beta but not IL 8 . 4 . ^^^ Carrageenin and LPS stimulated and production of immunoreactive TNFalpha , IL 1beta and IL 1ra in the skin of injected paws . 5 . ^^^ This effect is independent of ( IL 1ra induced ) IL 4 and IL 10 and appears to be the result of antagonism by IL 1ra of IL 1beta stimulated eicosanoid production . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RESULTS : Cardiopulmonary bypass induced release of antiinflammatory ( T 2 : IL 10 : median 25 pg / ml , 25th 75th percentile 9 42 ; IL 1ra : median 1 , 528 pg / ml , 25th 75th percentile 1 , 075 17 , 047 ; P < 0 . 05 compared with T 1 ) but failed to induce proinflammatory cytokines ( T 2 : TNF alpha : median 0 pg / ml , 25th 75th percentile 0 6 ; IL 1beta : median 1 pg / ml , 25th 75th percentile 0 81 ; nonsignificant ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The total content and the spontaneous and lipopolysaccharide ( LPS ) stimulated production of interleukin 1beta ( IL 1beta ) , IL 6 and IL 1 receptor antagonist ( IL 1Ra ) were determined in whole blood samples . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Because IL 1alpha and IL 1beta , and the anti inflammatory competitive inhibitor , IL 1 receptor antagonist ( IL 1Ra ) , have been implicated in the pathogenesis of myositis , we assessed the role of variable number tandem repeat ( VNTR ) polymorphisms of the IL 1Ra gene ( IL 1RN ) in the aetiology of JIIM : IL 1RN VNTR polymorphisms were performed on 250 JIIM patients and 471 race matched controls and were correlated with clinical characteristics . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
TNF alpha and IL 1beta promote leukocyte recruitment to arthritic joints and may contribute to cartilage degradation while regulatory cytokines such as IL 4 and IL 1RA may in part determine the course of arthritis . ^^^ Here we report the pattern of TNF alpha , IL 1beta , IL 6 , IFN gamma , IL 1RA , and IL 4 mRNA expression , detected by RT / PCR , in the talar joint and draining popliteal lymph node ( PLN ) of rats with adjuvant arthritis ( AA ) . ^^^ This was followed by increases in IL 1beta and IL 1RA mRNA at d 9 and IL 6 mRNA at d 12 . ^^^ PLN IL 1RA mRNA levels were positively correlated with those of IL 1beta and TNF alpha throughout d 5 d20 . ^^^ Yet no significant effect of CyA was observed on inflammatory cytokine expression , although the correlation between PLN IL 1RA and IL 1beta or TNF alpha was lost in treated animals . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Added IL 1beta augmented , whereas the IL 1beta receptor antagonist IL 1ra blocked , spontaneous iNOS induction . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Fibrosing alveolitis ( FA ) is characterized by persistent inflammation and elevated production of tumor necrosis factor alpha ( TNF alpha ) , interleukin 1 beta ( IL 1beta ) , and interleukin 1 receptor antagonist ( IL 1ra ) in the lung . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
HRT led to small increases in IL 1ra ( p < 0 . 001 ) and IL 6 ( p < 0 . 05 ) , with a decrease in sIL 6R ( p < 0 . 01 ) and no change in IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RNase protection assay with multiprobe template sets demonstrated that after incubation with OxLDL , the mRNAs of a variety of cytokines , including genes encoding IL 1Ra , IL 1beta , IL 6 , TNF alpha and beta , and interferon ( IFN ) gamma and beta , were significantly lower in the Mphi of patients . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : In the present study we have measured the concentrations of interleukin 6 ( IL 6 ) , soluble IL 6 receptor ( sIL 6R ) , tumor necrosis factor alpha ( TNF alpha ) , interleukin 1 beta ( IL 1 beta ) and IL 1 receptor antagonist ( IL 1Ra ) in the serum of patients with Graves ' disease ( GD ) . ^^^ Smoking had no effect on serum IL 6 , sIL 6R , TNF alpha , IL 1 beta and IL 1Ra concentrations , even in the presence of an active TAO . ^^^ Serum concentrations of IL 6 , sIL 6R , TNF alpha and IL 1 beta and IL 1Ra were not different in patients with and without TRAb or TPOAb , in relation to either thyroid function , TAO activity or smoking . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The concentrations of IL 6 , IL 1 receptor antagonist ( IL 1RA ) , IL 1beta , tumor necrosis factor ( TNFalpha ) and nerve growth factor ( NGF ) were measured from plasma and CSF from 22 patients with newly developed tonic clonic seizures within 24 h from the seizure and 18 controls . ^^^ The mean concentrations of IL 6 were significantly increased in CSF ( P < 0 . 001 ) and plasma ( P < 0 . 01 ) after tonic clonic seizures , there was some indication of increased concentrations of IL 1RA and no significant change in NGF , IL 1beta or TNFalpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHOD : We therefore investigated the frequency of polymorphisms in the genes encoding interleukin 1 beta ( IL 1 beta ) and its receptor antagonist ( IL 1RA ) in 70 EOP patients , including a subgroup of 21 localised EOP ( L EOP ) patients and 72 periodontally healthy controls . ^^^ CONCLUSIONS : These findings suggest that an IL 1 beta genotype in combination with smoking , and a combined IL 1 beta and IL 1RA genotype are risk factors for EOP and support a role for genetic and environmental factors in susceptibility to EOP . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : To examine whether the interleukin 1 receptor antagonist ( IL 1ra ) / IL 1 beta ratio can predict the clinical course , we prospectively followed the clinical courses of 30 patients with pulmonary sarcoidosis 4 years after measurement of immunoreactive amounts of IL 1ra or IL 1 beta in the culture supernatants obtained from BAL fluid macrophages . ^^^ METHODS : Immunoreactive amounts of IL 1ra or IL 1 beta were measured using ELISA . ^^^ RESULTS : We found that the patients whose shadows on chest radiographs showed improvement had a higher molar IL 1ra / IL 1 beta ratio than the patients whose shadows persistently remained 4 years after BAL examination ( p < 0 . 05 ) . ^^^ CONCLUSION : The IL 1ra / IL 1 beta ratio in the BAL fluid macrophage culture supernatants in patients with pulmonary sarcoidosis could be a useful marker in predicting the persistence of granulomatous lesions ( chronicity ) . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The system was modulated by the addition of monocytes ( U 937 cells ) , cytokines ( interleukin 1beta [ IL 1beta ] and tumor necrosis factor alpha [ TNFalpha ] ) , interleukin 1 receptor antagonist ( IL 1Ra ) , and monoclonal antibodies against IL 1beta and CD 44 . ^^^ IL 1Ra and anti IL 1beta monoclonal antibodies reduced the destruction of human matrix by 45 % and 35 % , respectively ; this was partially reversed by the addition of U 937 cells . ^^^ Based on the fact that proinflammatory cytokines enhance destruction whereas IL 1Ra and antibodies against IL 1beta and CD 44 inhibit the process , it is concluded that anti IL 1 and anti CD 44 directed therapies may help prevent cartilage destruction in RA . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Addition of purified recombinant HMG 1 to human monocyte cultures significantly stimulated the release of TNF , IL 1alpha , IL 1beta , IL 1RA , IL 6 , IL 8 , macrophage inflammatory protein ( MIP ) 1alpha , and MIP 1beta ; but not IL 10 or IL 12 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
BACKGROUND / AIMS : This study aimed to investigate the cytokine IL 1beta and its receptor antagonist IL 1ra in gingival crevicular fluid ( GCF ) , in patients with adult periodontitis . ^^^ IL 1beta and IL 1ra were quantified using new commercially available ELISA kits ( Quantikine ) , and could be detected in all samples . ^^^ For healthy sites , a strong inverse relationship was found between IL 1beta and IL 1ra levels in GCE . ^^^ CONCLUSIONS : The results suggest a strong relationship between the severity of adult periodontitis and the increasing GCF levels of IL 1beta and decreasing levels of IL 1ra . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Clinical indices of disease activity , disability and joint destruction and plasma levels of IL 1beta , IL 1Ra and sCD 23 were assessed to evaluate a possible functional effect . ^^^ Plasma levels of IL 1beta , IL 1Ra and sCD 23 , known to be modified by IL 4 , were not different in individuals having different alleles . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
An imbalance in IL 1 beta / IL 1RA was found in severe AP and pulmonary failure . ^^^ CONCLUSION : Our results suggest that local mediator release , with a probable IL 1 beta IL 1RA imbalance in severe cases , is followed by the systemic appearance of pro and anti inflammatory mediators . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Injections of IL 1RA decreased the concentration of IL 1beta and TNF alpha and resulted in survival of all infected mice ( treatment group ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin ( IL ) 1 alpha , IL 1 beta , IL 1 receptor antagonist ( IL 1Ra ) , and IL 6 expression was higher in the rejection group than in patients without rejection . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Exogenously applied IL 1beta prolongs seizures in an IL 1R type 1 mediated manner . ^^^ These results demonstrate that IL 1Ra mediates potent anticonvulsant effects acting on IL 1R type 1 and suggest that the balance between brain IL 1beta and IL 1Ra represents a crucial mechanism to control seizure generalization . . ^^^ IL 1beta and its endogenous receptor antagonist ( IL 1Ra ) are rapidly induced by seizures in the rodent hippocampus . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Imbalance production between interleukin 1beta ( IL 1beta ) and IL 1 receptor antagonist ( IL 1Ra ) in bronchial asthma . ^^^ Genes of the IL 1 family encode three different peptides , IL 1alpha , IL 1beta , and IL 1Ra , respectively . ^^^ Since Th 1 and Th 2 cytokines differentially regulate the ratio between IL 1beta and IL 1Ra , these findings suggest that dysregulation of IL 1beta / IL 1Ra , probably due to interaction between epithelium and immuno competent cells in the airway , is important in asthma inflammation . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To confirm that colostrum contains a variety of cytokines with immunomodulatory properties , we established a bovine cytokine specific ELISA and five cytokines ( IL 1 beta , IL 6 , TNF alpha , INF gamma or IL 1 receptor antagonist , IL 1ra ) in the whey samples from cows at different stages of lactation were monitored . ^^^ A positive correlation was observed between the concentrations of IL 1ra and IL 1 beta in the colostrum samples . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The proinflammatory cytokines interleukin 8 ( IL 8 ) , tumor necrosis factor alpha ( TNFalpha ) , and interleukin 1beta ( IL 1beta ) are smaller than the antiinflammatory cytokines interleukin 10 ( IL 10 ) , interleukin 1 receptor antagonist ( IL 1ra ) , and TNF soluble receptor 2 ( TNFsr 2 ) , and thus undergo glomerular filtration more readily . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The present study , which is based on long term follow up of a cohort of 37 patients , relates peripheral blood mononuclear cell ( PBMC ) interleukin 1 receptor antagonist ( IL 1Ra ) synthesis ( a reliable marker of IL 1beta synthesis in HD patients ) and plasma levels of an acute phase reactant , lipopolysaccharide binding protein ( LBP ) , to clinical outcomes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In addition , recombinant human IL 1beta , recombinant human IL 1 receptor antagonist ( IL 1ra ) and a neutralizing goat antibody against type 1 human IL 1 receptor were used to study the involvement of IL 1 in the release of IL 8 . ^^^ IL 1ra and the neutralizing antibody significantly blocked the ability of IL 1beta to stimulate secretion of IL 8 by MAC T cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In this study , we investigated the effects of IFN gamma on the production of cytokines ( IL 6 , IL 8 , IL 10 ) , prostaglandin E ( 2 ) ( PGE ( 2 ) ) , proteoglycans ( PG ) , nitric oxide ( NO ) , interleukin 1 receptor antagonist ( IL 1ra ) and stromelysin by non stimulated and IL 1 beta treated human chondrocytes . ^^^ RESULTS : As expected , IL 1 beta highly stimulated NO , IL 6 , IL 8 , IL 10 , IL 1ra , PGE ( 2 ) and stromelysin synthesis , but dramatically decreased PG production . ^^^ Interestingly , IFN gamma synergized with IL 1 beta to increase NO , IL 6 , IL 1ra and to depress PG production . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In situ IL 1beta and IL 1Ra expression was evaluated by immunohistochemistry ; their production was assayed by enzyme linked immunosorbent assay and the gene polymorphisms by reverse transcriptase polymerase chain reaction on blood cells . ^^^ Hepatic IL 1beta and IL 1Ra expression were enhanced during rejection . ^^^ IL 1beta and IL 1Ra gene polymorphisms did not differ between patients with and without steroid resistance . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In this study , specific binding of IL 1beta to the surface of S . aureus significantly increased growth of S . aureus in the presence of IL 1beta and IL 1ra in a concentration dependent manner . ^^^ Although IL 1ra enhanced the growth of S . aureus , there was a significant reduction in IL 1beta mediated growth enhancement of S . aureus when 25 fold excess amounts of IL 1ra ( in comparison with the IL 1beta concentration ) were present in the culture medium . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin ( IL ) 1 like protein 1 ( IL 1L1 ) is a 155 amino acid protein that shares 27 % identity with IL 1beta and 47 % with IL 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
All measured plasma cytokine concentrations were significantly elevated immediately postrace , with the magnitude of increase for tumor necrosis factor alpha ( TNF alpha ) and interleukin 1beta ( IL 1beta ) much smaller than for IL 6 , IL 10 , IL 8 , and IL 1 receptor antagonist ( IL 1RA ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In kidneys treated to develop UUO , levels of ICAM 1 , IL 1 beta , and IL 1R expression increased within 3 days compared with contralateral untreated kidneys in the same mice . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1beta ( IL 1beta ) and its endogenous antagonist , the interleukin 1 receptor antagonist ( IL 1ra ) , play important roles in immune responses . ^^^ In sarcoidosis , IL 1beta is reported to be increased whereas IL 1ra is decreased . ^^^ It has recently been shown that polymorphisms in the IL 1ra and IL 1beta genes may account for variation in the two proteins . ^^^ The IL 1ra genotype was determined using the polymerase chain reaction ( PCR ) , and the IL 1beta genotype by PCR restriction fragment length polymorphism . ^^^ In conclusion , there is no bias in the IL 1ra and IL 1beta genotype in Japanese sarcoidosis patients . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The expression levels of inflammatory cytokine mRNA of interleukin 1beta ( IL 1beta ) and 2 forms ( secreted type and intracellular type ) of IL 1 receptor antagonist ( IL 1ra ) were measured by reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Co incubation of PMNs with LPS and bovine recombinant IL 1beta had little additional effect on type 1 IL 1R expression . ^^^ Incubation of MNCs with LPS resulted in up regulation of IL 1beta , IL 1ra , and type 2 IL 1R , no change in IL 1alpha , and a decrease in ICE gene expression . ^^^ Incubation of PMNs with LPS up regulated IL 1beta gene expression , whereas , IL 1alpha , IL 1ra , type 2 IL 1R and ICE were unchanged . ^^^ Gene expression of mRNA for IL 1alpha , IL 1beta , IL 1 receptor antagonist ( IL 1ra ) , type 1 IL 1 receptor , type 2 IL 1 receptor , and IL 1 beta converting enzyme ( ICE ) , were measured by a semi quantitative RT PCR technique . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The cytokines interleukin 1 beta ( IL 1 beta ) and IL 1 receptor antagonist ( IL 1ra ) are rapidly induced in response to excitotoxic and ischemic brain damage . ^^^ Peripheral administration of kainic acid ( 10 mg / kg , i . p . ) results in a transient expression of IL 1 beta and IL 1ra mRNA , mainly in microglia , in regions showing neurodegeneration such as the hippocampus , thalamus , amygdala , and certain cortical regions . ^^^ MK 801 at 3 . 0 mg / kg decreased the IL 1 beta mRNA expression , blocked or decreased the IL 1ra mRNA expression , depending on the brain region . ^^^ MK 801 at 5 . 0 mg / kg abolished IL 1ra mRNA expression in all of the regions , whereas the IL 1 beta mRNA expression was decreased or blocked , depending on the brain region , or the time point investigated . ^^^ The finding that NMDA receptor antagonists inhibit the IL 1 beta and IL 1ra mRNA synthesis induced by kainic acid suggests that NMDA receptor activation may be involved in triggering cytokine synthesis following excitotoxic brain damage . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In normal mice , the role of IL 1 beta was assessed by pretreating the animal with the IL 1 receptor antagonist ( IL 1Ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Plasma IL 1beta concentrations remained at basal after 1 h restraint and the stress induced increase of plasma corticosterone was not modified by a peripheral injection of an IL 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We have investigated the serum levels of IL 1 components ( IL 1alpha , IL 1beta , and IL 1Ra ) , and determined the role of intravenous immunoglobulin ( IVIg ) therapy in patients with CP . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In addition , although IL 1ra levels are elevated in most of the TMD patients , the increases do not appear to be sufficient to inhibit the inflammation and connective tissue degradation associated with IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Fifty two patients with AD and 25 healthy controls were analyzed with respect to cerebrospinal fluid ( CSF ) levels of IL 1beta and IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Since production of IL 1ra in human endometrium is reported to be 10 to 30 fold higher than that of IL 1 alpha / beta , we investigated whether endogenous IL 1 beta secreted from human endometrial stromal cells can be inhibited by IL 1ra by using an in vitro decidualization culture . ^^^ Although IL 1 beta showed a biphasic effect on cell proliferation and a suppressive effect on decidualization of stromal cells , these effects were completely inhibited by IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present study , we examined a G / C polymorphism at position 174 in the promoter region of IL 6 , a biallelic polymorphism at position 308 in the promoter region of TNF alpha , the TaqI restriction fragment length polymorphism in exon 5 of IL 1beta and a variable number of identical tandem repeat polymorphisms in intron 2 of IL 1 receptor antagonist ( IL 1Ra ) genes . ^^^ No difference was found between patients and healthy controls or between MM and MGUS patients in the distributions of genotypes and frequencies of alleles of the IL 6 ( 174 ) , TNF alpha ( 308 ) , IL 1beta TaqI and IL 1Ra gene polymorphisms . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Serum samples from 20 untreated patients with active PV prior to initiation of systemic therapy , 20 patients receiving IVIG treatment , 20 patients in clinical remission after conventional therapy , and 20 normal human controls were studied to determine the serum levels of IL 1alpha , IL 1beta , and IL 1Ra . ^^^ Similar differences in the levels of IL 1alpha , IL 1beta , and IL 1Ra were found in the culture supernatant of PBMC isolated from the PV patients pre and post IVIG therapy . ^^^ These observations suggests that , compared to normal controls , patients with active PV have reversed levels of IL 1alpha , IL 1beta , and IL 1Ra . ^^^ IVIG therapy may down regulate production of IL 1alpha and IL 1beta and enhance production of IL 1Ra , in vivo and in vitro . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RESULTS : Infected neonates had higher levels of TNFalpha , IL 1beta , IL 6 , IL 8 , p 55 , p 75 and IL 1RA than healthy controls ( all p < 0 . 01 ) . ^^^ CONCLUSIONS : Early onset neonatal sepsis is associated with a prenatal immune response with increased TNFalpha , IL 1beta , IL 6 , IL 8 , p 55 , p 75 and IL 1RA levels in umbilical plasma . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1B and IL 1Ra gene polymorphisms and disease severity in rheumatoid arthritis : interaction with their plasma levels . ^^^ We analysed the frequency of different alleles in the IL 1B gene ( at 511 and at +3954 ) as well as in the IL 1Ra gene ( at +2018 ) in an association study involving 297 RA patients and 112 healthy controls from the same geographic area . ^^^ We tested associations with RA susceptibility or severity , and with circulating levels of IL 1Ra and IL 1beta . ^^^ This IL 1B ( +3954 ) gene polymorphism may be an important marker for the severity of joint destruction in RA and is associated with an imbalance in IL 1Ra production . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Sprague Dawley rats were anesthetized with inhalation of halothane , after which a single injection of 5 microl of IL 1beta ( 0 . 1 to 10 ng / eye ) ( and / or IL 1 receptor antagonist ( IL 1ra ) ) for experimental eyes was administered . ^^^ Our studies suggest that IL 1beta induces neuronal cell death directly , as shown by the protective effects of IL 1ra , but has a protective effect on NMDA induced retinal damage indirectly after an incubation time of at least 2 days . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We collected and analyzed DNA from 98 MS patients and 104 healthy controls for distribution of IL 1beta or IL 1ra polymorphisms . ^^^ Furthermore , no association was observed between IL 1beta or IL 1ra polymorphisms and clinical characteristics , such as age at disease onset , clinical course and severity . ^^^ Together , our findings suggest that IL 1beta or IL 1ra gene polymorphisms may not be relevant in the susceptibility to MS or the clinical characteristics of Japanese patients with MS . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In this in vitro study we evaluated some commercially available blood tubings sterilized by different methods as to their interaction with normal leukocyte population and tested the response of these cells in terms of cytokines ( IL 1beta , IL 1Ra , TNF alpha ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We have reported a decreased ratio of interleukin 1beta ( IL 1beta ) to interleukin 1 receptor antagonist ( IL 1ra ) produced by whole blood cultures in vivo in women taking hormone replacement therapy ( HRT ) . ^^^ Cytokines IL 1beta , interleukin 1alpha ( IL 1alpha ) , IL 1ra , interleukin 6 ( IL 6 ) , TNF alpha , and granulocyte macrophage colony stimulating factor ( GM CSF ) were measured in unstimulated and in stimulated ( 500 ng / mL lipopolysaccharide [ LPS ] ) whole blood cultures treated with 17beta estradiol ( E ( 2 ) ) at concentrations of 10 ( 12 ) 10 ( 6 ) mol / L . ^^^ We found significant decreases in the spontaneous secretion of IL 6 , TNF alpha , IL 1ra , IL 1beta , and ratio of IL 1beta / IL 1ra compared with control , at physiological concentrations of E ( 2 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : The concentrations of IL 1 alpha , IL 1 beta ( precursor and mature forms ) , and IL 1 receptor antagonist ( IL 1Ra ) were measured by ELISA in tear fluid samples obtained from normal individuals and patients with dry eye who had rosacea associated meibomian gland disease ( MGD ) or Sjgren ' s syndrome ( SS ) aqueous tear deficiency ( ATD ) . ^^^ There was no significant change in the concentration of IL 1 alpha , precursor IL 1 beta , and IL 1Ra in reflex tear fluid , indicating that the lacrimal glands may secrete these cytokines . ^^^ Positive immunofluorescent staining for IL 1 alpha , mature IL 1 beta , and IL 1Ra was observed in a significantly greater percentage of conjunctival cytology specimens from eyes with SS ATD than in those from normal eyes ( P < 0 . 01 for IL 1 alpha , P < 0 . 009 for mature IL 1 beta , and P < 0 . 05 for IL 1Ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1beta ( IL 1beta ) and the interleukin 1 receptor antagonist ( IL 1ra ) are cytokines that play a key role in modulating the inflammatory response in the gastrointestinal mucosa . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Influence of the IL 1Ra gene polymorphism on in vivo synthesis of IL 1Ra and IL 1beta after live yellow fever vaccination . ^^^ The IL 1 complex contains polymorphic genes coding for IL 1alpha , IL 1beta and IL 1Ra . ^^^ The IL 1Ra ( variable number of tanden repeat ) VNTR polymorphism has been shown to influence the capacity to produce IL 1beta and IL 1Ra after in vitro stimulation . ^^^ Carriers of allele 2 of the IL 1Ra polymorphism had increased baseline concentrations of IL 1Ra ( 350 + / 32 pg / ml ) compared with non carriers ( 222 + / 18 pg / ml , P < 0 . 001 ) , and decreased concentrations of IL 1beta ( 0 . 9 + / 0 . 2 pg / ml for carriers versus 2 . 8 + / 0 . 7 pg / ml for non carriers , P = 0 . 017 ) . ^^^ This is the first study to examine the influence of this genetic polymorphism on in vivo induced human IL 1beta and IL 1Ra synthesis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The values of LM indices were compared with the ratios of IL 1ra / IL 1beta concentration estimated by enzyme linked immunosorbent assay method in the culture supernatants . ^^^ The influences of exogenous IL 1beta , IL 1ra , anti IL1ra antibodies and antibiotic cefaclor on the monokine concentrations and on the values of LM index were tested . ^^^ RESULTS AND CONCLUSIONS : The results show that the level of lymphocyte response to delayed stimulation with PHA ( LM index ) is inversely proportional to the ratio of IL 1ra / IL 1beta concentration in the culture . ^^^ The low LM values at high IL 1ra / IL 1beta ratios in PBMC cultures from healthy donors , reversed proportions found in patients ' PBMC ( acute tonsilitis ) , and the cefaclor induced reduction of LM value with correlated increase of the IL 1ra / IL 1beta ratio suggest that the LM assay may prove to be useful for immunodiagnostic purposes . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To elucidate a genetic predisposition of temporal lobe epilepsy with hippocampal sclerosis ( TLE HS+ ) , we studied polymorphisms in the IL 1beta , IL 1alpha , and IL 1 receptor antagonist ( IL 1RA ) genes in 50 patients with TLE HS+ and in 112 controls . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : To determine the relationship between the expression of interleukin 1beta ( IL 1beta ) and IL 1 receptor antagonists ( IL 1ra ) in the subacromial bursa and shoulder pain in rotator cuff diseases . ^^^ RESULTS : The mRNA expression levels of the cytokines were significantly correlated with the degree of pain [ IL 1beta : r=0 . 782 ; secreted IL 1ra ( sIL 1ra ) : r=0 . 756 ; intracellular IL 1ra ( icIL 1ra ) : r=0 . 806 , P < 0 . 001 , respectively ] . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In monocytes stimulated by LPS , IL 1beta , but not IL 1Ra transcripts were redistributed and partially associated , yet not bound to actin microfilaments . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 receptor antagonist ( IL 1ra ) is known to inhibit the effects of IL 1alpha and IL 1beta , resulting in attenuated inflammatory injury , and to protect cells from IL 1beta induced apoptosis in vitro . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Role of IL 18 in the secretion of Il 1beta , sIL 1RII , and IL 1Ra by human neutrophils . ^^^ In the present study we investigated the effect of IL 18 on the production of IL 1beta , IL 1Ra and sIL 1RII by human neutrophils . ^^^ Our observations indicate that rhIL 18 induces IL 1beta and , to a lesser extend , IL 1Ra and sIL 1RII production by human neutrophils isolated form peripheral blood . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
These results suggest that coexistence of IL 1ra with IL 1 in colostrum may have no effect on the activation of the neonatal immune system by IL 1beta . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Conditioned medium derived from LPS activated / ATP treated human monocytes maintained in the absence and presence of CP 424 , 174 contained comparable quantities of IL 6 , tumor necrosis factor alpha ( TNFalpha ) , and IL 1RA , but 30 fold less IL 1beta was generated in the test agent ' s presence . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Activation with a combination of phytohemagglutinin ( PHA ) and LPS was used to assess secretion of IL 2 , IFN gamma , IL 4 , IL 10 , soluble IL 2 receptor alpha ( sIL 2Ralpha ) , IL 1beta , and IL 1R antagonist ( IL 1Ra ) by PBMC in 48 h cell culture . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The purpose of this study was to evaluate if IL 1beta ( IL 1beta promoter and IL 1beta exon 5 ) and IL 1receptor antagonist ( IL 1Ra ) gene polymorphisms act as markers of susceptibility to or severity of RA . ^^^ This study indicated that allelic frequency and carriage rate of IL 1beta ( IL 1beta promoter and IL 1beta exon 5 ) and IL 1Ra ( 1 and 2 allele ) do not differ significantly between normal controls and RA patients in Taiwan . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : To examine the correlation between C reactive protein ( CRP ) and CRP inducing cytokines ( IL 1 beta , IL 6 , TNF alpha ) and IL 1 receptor antagonist ( IL 1ra ) , as well as to study their relationship with systemic lupus erythematosus disease activity ( SLEDAI ) in newly diagnosed , untreated lupus patients . ^^^ Except IL 1ra , which was correlated with CRP ( p = 0 . 045 ) , no substantial correlation was discovered between CRP and IL 6 , IL 1 beta or TNF alpha individually . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We observed that : ( 1 ) intracerebral ventricular injection of ( ICV ) IL 1beta induced pressor responses ; ( 2 ) hypertension induced by IL 1beta was blocked by ICV an IL 1 antagonist , IL 1ra ; ( 3 ) ICV IL 1ra attenuated the pressor response induced by FS but intravenous injection of IL 1ra did not significantly reduce this response ; ( 4 ) the hypertensive response to conditioned fear stimuli was reversed by ICV IL 1ra ; ( 5 ) FS induced analgesia was attenuated by ICV IL 1ra and this effect disappeared 15 min after ICV IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 receptor antagonist ( IL 1Ra ) blocked both hypoxic astrocyte conditioned media induced NF kappaB activation and the expression / release of IL 1beta and IL 8 . ^^^ Astrocytes subjected to hypoxia in the presence of IL 1Ra failed to activate NF kappaB , but expressed elevated levels of IL 1beta and IL 8 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Injection of S AMPA alone increased IL 6 mRNA expression in the ipsilateral striatum after 8 h , whilst striatal injection of IL 1beta alone increased local IL 1beta and IL 1ra mRNAs . ^^^ The levels of mRNA encoding IL 1alpha , IL 1beta , IL 1ra , IL 6 , IL 10 and TNFalpha were markedly elevated in the ipsilateral cortex 8 h after co injection of S AMPA and hrIL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : Polymerase chain reaction techniques were performed either in a thermal cycler using standard methods or in a light cycler to analyze the frequencies of the TNFalpha ( 308 ) , IL 1 receptor antagonist ( IL 1Ra ) ( intron 2 ) , IL 1beta ( exon 5 ) , and IL 6 ( 174 ) polymorphisms in 61 OA patients and 254 randomly chosen controls . ^^^ CONCLUSION : These results point to an association between the IL 1beta polymorphism and the TNFalpha ( high ) phenotype and between the IL 1Ra polymorphism and the TNFalpha ( low ) phenotype found in OA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Analysis of cytokine expression profiles of 3 D Int 407 cells and monolayers following infection with Salmonella revealed significant differences in expression of interleukin 1alpha ( IL 1alpha ) , IL 1beta , IL 6 , IL 1Ra , and tumor necrosis factor alpha mRNAs between the two cultures . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta stimulates osteoclast activity while interleukin 1 receptor antagonist ( IL 1ra ) enhances bone formation . ^^^ AIMS : To determine whether the decreased bone mass in IBD is related to gene polymorphisms coding for IL 1beta and IL 1ra , and thus identify patients with an increased risk . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
No statistically significant differences were found in the genotype distributions , allelic frequencies and A2+ carrier status of IL 1alpha , IL 1beta , IL 1RA , IL 6 , IL 10 , and TNF alpha genes between nonagenarians and younger controls within Finnish population , nor between male and female nonagenarians . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
PURPOSE : We aimed to investigate if interleukin 1 beta ( IL 1 beta ) and IL 1 receptor antagonist ( IL 1Ra ) gene polymorphism could be used as markers of susceptibility in endometriosis . ^^^ Polymorphisms for IL 1 beta 511 promoter , IL 1 beta exon 5 , and IL 1Ra were detected by polymerase chain reaction . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin ( IL ) 1alpha , IL 1beta , and IL 1ra contribute to regulation of the inflammatory response in periodontal tissues . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To address the possibility that FN f induced NO release is mediated by IL 1beta production , the effect of IL 1 receptor antagonist ( IL 1ra ) was determined . ^^^ IL 1ra partially inhibited FN f induced NO release although it almost completely inhibited IL 1beta induced NO release . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Manipulations of IL 1 were accomplished by adding specific neutralizing monoclonal antibodies or recombinant IL 1RA , IL 1 alpha , or IL 1 beta . ^^^ RESULTS : Blocking the IL 1 receptor with IL 1RA or neutralizing IL 1 alpha or IL 1 beta with specific antibody dramatically suppressed IgG 2 production ( 50 % to 70 % ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1ra ( 0 . 5 and 50 ng 10 ml ( 1 ) , respectively ) , an endogenous molecule that antagonizes most of the biological actions of IL 1beta , or by an antibody ( 5 and 50 ng 10 ml ( 1 ) ) which blocks the human IL 1 receptor type 1 ( IL 1RI ) . 3 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present study , the role of IL 1 receptor binding sites in the regulation of NGF release was evaluated by determining the pharmacological properties of astroglially localized IL 1 receptors , and , by comparing the effects of both the agonists ( IL 1 alpha and IL 1 beta ) and the antagonist ( IL 1ra ) members of the IL 1 family on NGF secretion from rat neonatal cortical astrocytes in primary culture . ^^^ IL 1 receptor agonists IL 1 alpha ( K ( 1 ) of 341 . 1 pM ) and IL 1 beta ( K ( 1 ) 59 . 9 pM ) , as well as the antagonist IL 1ra ( K ( 1 ) 257 . 6 pM ) , displaced specific [ ( 125 ) 1 ] IL 1 beta binding from cultured astrocytes in a monophasic manner . ^^^ IL 1ra had no effect on basal NGF release but dose dependently inhibited the stimulatory response induced by IL 1 beta . ^^^ We concluded that IL 1 beta induced NGF secretion from cultured rat cortical astrocytes is mediated by functional type 1 IL 1 receptors , whereas IL 1 alpha and IL 1ra , in spite of their affinity for IL 1RI , have no effect on NGF secretion from these cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Tissue expression of IL 1 beta mRNA and IL 8 mRNA was then studied by in situ hybridization before and after IL 1ra administration . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The purpose of this study was to investigate the time course of release of the cytokines / chemokines interleukins ( IL ) IL 1beta , IL 1ra , tumour necrosis factor alpha ( TNF alpha ) , IL 6 , IL 8 , interferon gamma ( IFN gamma ) and monocyte chemotactic protein ( MCP 1 ) , soluble intercellular adhesion molecule 1 ( sICAM 1 ) , myeloperoxidase ( MPO ) and bradykinin in nasal secretions of patients with a naturally acquired URTI . ^^^ Compared to baseline , significantly elevated concentrations of total protein , bradykinin , IL 1beta , TNF alpha , IL 6 , IL 8 , MCP 1 , IFN gamma , MPO and sICAM 1 were detected in nasal lavage fluids of symptomatic patients , whereas IL 1ra remained unaltered . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We then applied this technique to determine the kinetics of IL 1ra , IL 1beta , IL 5 , IL 13 , TNF alpha and IFN gamma induction upon stimulation of human peripheral blood mononuclear cells ( PBMC ) by phytohaemagglutinin ( PHA ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1RA gene is polymorphic , resulting in quantitative differences in both IL 1RA and IL 1beta production . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Polymorphic sites in genes of the IL 1 family were examined , including the 86 base pair variable number tandem repeat within intron 2 of the IL 1Ra gene , and the restriction fragment length polymorphisms at positions 889 in the IL 1alpha gene and 511 in the IL 1beta gene . ^^^ RESULTS : No significant differences were seen at the polymorphic alleles in the IL 1alpha and IL 1beta genes , but there was a significant increase in the carriage of allele 2 in the IL 1Ra in the AS patients compared with local controls ( 16 vs 8 % , odds ratio 2 . 3 , 95 % confidence interval 1 . 2 4 . 4 , P=0 . 01 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta actions depend on interaction with a single receptor ( IL 1RI ) , which associates with an accessory protein ( IL 1RAcP ) , and is blocked by IL 1 receptor antagonist ( IL 1ra ) . ^^^ Here we show that in normal mice [ wild type ( WT ) ] , intracerebroventricular injection of IL 1ra markedly reduces ( 50 % ; p < 0 . 01 ) ischemic brain damage caused by reversible occlusion of the middle cerebral artery , whereas injection of IL 1beta exacerbates damage ( +45 % ; p < 0 . 05 ) . ^^^ This effect of IL 1beta was abolished by heat denaturation in all animals , and was reversed by IL 1ra in WT , but not IL 1RI KO mice . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the synovial fluid levels of interleukin 1 beta ( IL 1 beta ) , tumour necrosis factor alpha ( TNF alpha ) , transforming growth factor beta ( TGF beta ) , IL 1 receptor antagonist ( IL 1ra ) , soluble IL 2 receptor ( sIL 2r ) and IL 8 in patients with Behet ' s disease ( BD ) and to compare them to levels in rheumatoid arthritis ( RA ) , and osteoarthritis ( OA ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
For instance , in chronic myelogenous leukemia , high cellular ( leukocyte ) levels of IL 1 beta and low levels of IL 1 receptor antagonist ( IL 1RA ) are seen in advanced disease and correlate with reduced survival . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To determine the role of interleukin 1 ( IL 1 ) herein , extrahepatic cholestasis was induced by bile duct ligation ( bdl ) in IL 1 receptor type 1 gene deficient ( IL 1R ( / ) ) mice , which are unresponsive to IL 1alpha and IL 1beta , and normal IL 1R ( + / + ) mice . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We have , therefore , performed a case control study to investigate a plausible association between sarcoidosis and the polymorphisms in the IL 1alpha , IL 1beta , and IL 1 receptor antagonist ( IL 1Ra ) genes . ^^^ Using PCR with sequence specific primers , IL 1alpha 889 , IL 1beta 511 , IL 1beta +3953 , and IL 1Ra intron 2 VNTR polymorphisms were determined in 348 white subjects of West Slavonic ancestry ( 95 patients with sarcoidosis , 54 patients with IPF , and 199 healthy control subjects ) . ^^^ The distribution of IL 1beta 511 , IL 1beta +3953 , and IL 1Ra VNTR genotypes and alleles did not significantly differ between the cases and controls . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The secretion of IL 1ra , IL 1 alpha and IL 1 beta in the supernatant of GM CSF ( 10 ng / ml ) treated and untreated monocytes were measured by ELISA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : Interleukin 1 beta ( IL 1 beta ) and interleukin 1 receptor antagonist ( IL 1Ra ) produced by cultured peripheral blood mononuclear cells ( PBMC ) after exposure to cuprammonium ( Cup ) membrane , polysulfone ( PS ) membranes or endotoxin were detected using enzyme linked immunoabsorbent assay . mRNA expression was determined simultaneously by in situ hybridization . ^^^ Although no differences could be found in protein synthesis between Cup and PS , in situ hybridization showed that Cup induced markedly higher level mRNA coding for IL 1 beta and IL 1Ra . ^^^ In contrast , when subsequently stimulated with endotoxin , PBMC incubated with Cup could produce significantly larger amount of IL 1 beta and IL 1Ra compared with either unstimulated cells or post incubation PBMC with PS . ^^^ LPS stimulated PBMC in healthy subjects produced similar amount of IL 1 beta and markedly lower IL 1Ra as compared with uremic patients on HD and CAPD . ^^^ CONCLUSIONS : Two steps are required in healthy control for IL 1 beta and IL 1Ra production : induction of mRNA transcription by membrane contact , followed by LPS induced translation , while in uremic patients on HD or CAPD bioincompatibility membrane and LPS have a synergetic effect on IL 1 beta and IL 1Ra production . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta , IL 1Ra and sIL 1RII in the culture supernatants of PMN and PBMC and the serum levels in patients with inflammation and patients with cancer disease of the same location . ^^^ The results obtained revealed changes in the secretion of IL 1beta and IL 1Ra which are more characteristic of PMN and PBMC from cancer patients than of the cells from patients with inflammation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
As a negative feedback mechanism , IL 1beta induced its natural antagonist , IL 1Ra . ^^^ Both endogenous and exogenous IL 10 suppressed IL 1beta and induced IL 1Ra , thus markedly decreased the amount of functional IL 1 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
These encode IL 1alpha and IL 1beta , as well as their endogenous receptor antagonist , IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In addition to its fundamental pro inflammatory role , the interleukin 1 ( IL 1 ) system has major effects on hair growth regulation in vitro , with the inhibitory actions of IL 1alpha and IL 1beta being opposed by the receptor antagonist IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : We studied by polymerase chain reaction ( PCR ) polymorphisms of important cytokine genes of inflammation interleukin 1 ( IL 1beta ) , tumor necrosis factor alpha ( TNF alpha ) , interleukin 6 ( IL 6 ) , and interleukin 1 receptor antagonist ( IL 1Ra ) in 167 patients with IgAN and 400 healthy blood donor controls . ^^^ RESULTS : Carriage of the IL 1beta allele 2 ( IL1beta2 ) or IL 1Ra allele 2 ( IL1RN * 2 ) was associated with an increased risk of IgAN . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Effect of IL 15 on the secretion of IL 1beta , IL 1Ra and sIL 1RII by PMN from cancer patients . ^^^ In the present study , we demonstrate an effect of rhIL 15 on the simultaneous secretion of IL 1beta and its natural inhibitors IL 1Ra and sIL 1RII by human neutrophils isolated from normal and tumour bearing hosts ( oral cavity cancer and melanoma patients ) compared with serum IL 15 levels . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1RII ( + ) chondrocytes were more resistant to induction of NO and PGE ( 2 ) by IL 1beta compared with IL 1RII ( ) cells incubated with a 10 fold ( weight ) excess of soluble type 2 IL 1R ( sIL 1RII ) protein . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Susceptibility for and clinical manifestations of rheumatoid arthritis are associated with polymorphisms of the TNF alpha , IL 1beta , and IL 1Ra genes . ^^^ METHODS : Polymerase chain reaction amplification was used for analysis of TaqI restriction fragment length polymorphism ( RFLP ) of interleukin 1 beta ( IL 1beta ) , variable tandem repeat polymorphism of IL 1 receptor antagonist ( IL 1Ra ) gene and NcoI RFLP at position 308 of tumor necrosis factor alpha ( TNF alpha ) gene . ^^^ The allelic combination Al IL 1beta / A2 IL 1Ra was less prevalent in RA patients who developed cardiovascular complications ( p < 0 . 005 ; OR = 0 . 20 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVES : To investigate whether the interleukin 1 receptor antagonist ( Il 1ra ) and interleukin 1beta ( Il 1beta ) can be detected in human carotid artery tissue , and whether their presence is related to evidence of Chlamydia pneumoniae infection , risk factors for atherosclerosis , and clinical data . ^^^ Il 1beta and Il 1ra were studied in carotid artery plaques and in Il 1ra in serum . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To determine which cytokines may be relevant , levels of interleukin 1alpha ( IL 1alpha ) , interleukin 1beta ( IL 1beta ) , interleukin 1 receptor antagonist ( IL 1ra ) , interleukin 6 ( IL 6 ) and interferon gamma ( IFN gamma ) mRNA were quantitated in gingival tissue from periodontitis patients and healthy controls . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In a prospective clinical study of 50 patients with Dengue Shock Syndrome ( DSS ) , we investigated the association of tumor necrosis factor alpha ( TNF alpha ) , interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1Ra ) , and IL 6 with activation markers of coagulation ( F1+2 and TATc ) and fibrinolysis ( t PA , PAPc , and D dimer ) . ^^^ We found that TNF alpha , IL 1beta and Il 1Ra , but not IL 6 , concentrations were elevated in the circulation during the early stage of infection and at discharge from hospital . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : We evaluated CP immunoglobulin G ( IgG ) seropositivity and IL 1 beta ( a C / T transition at 511 ) and IL 1 receptor antagonist ( IL 1Ra ) ( a variable number repeat in intron 2 ) gene polymorphisms in 292 patients undergoing coronary angiography . ^^^ The percentage of patients having IL 1 beta ( 511 ) C / C genotype and / or IL 1Ra ( intron 2 ) 2 or 3 repeat allele was higher in patients with CAD than without CAD ( 29 vs . 16 % , p < 0 . 025 ) . ^^^ To clarify the effects of these CAD associated variants ( IL 1 beta C / C and / or IL 1Ra 2 or 3 repeat ) , patients were divided into four groups . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
FB 1 caused increased expression of tumor necrosis factor alpha ( TNFalpha ) , interleukin ( IL ) 1alpha , IL 1beta , IL 1 receptor antagonist ( IL 1Ra ) , IL 6 , IL 10 , IL 12 p 40 , IL 18 and interferon gamma ( IFNgamma ) in male liver , with a similar increase in females except for IL 1beta and IL 18 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The aim of this study was to characterize the isoforms of IL 1 receptor antagonist ( IL 1ra ) in cultured human primary OMECs and to compare its production with that of IL 1 alpha ( IL 1alpha ) and IL 1 beta ( IL 1beta ) . ^^^ In unstimulated culture lysates , there was far more IL 1ra than IL 1alpha and IL 1beta . ^^^ TGF beta 1 markedly increased the IL 1ra / IL 1beta ratio from 93 . 6 : 1 to 300 : 1 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
This study shows that treatment of human intestinal epithelial T 84 cells with Etx induces expression of IL 6 , IL 10 , IL 1R antagonist , as well as IL 1alpha and IL 1beta and low levels of IL 8 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We also observed that PMA upregulated the production of both IL 1beta and of IL 1 receptor antagonist ( IL 1ra ) . ^^^ IL 4 inhibited the secretion of IL 1beta and strongly increased that of IL 1ra ; however , these effects were not responsible of IL 4 mediated inhibition of PMA induced HIV expression since anti IL 1ra antibodies did not revert IL 4 mediated suppression . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The pro inflammatory cytokines interleukin 8 ( IL 8 ) , tumour necrosis factor alpha ( TNF alpha ) and interleukin 1beta ( IL 1beta ) have lower molecular weights than the anti inflammatory cytokines interleukin 10 ( IL 10 ) , interleukin 1 receptor antagonist ( IL 1ra ) and TNF soluble receptor 2 ( TNFsr 2 ) and thus undergo glomerular filtration more readily . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : We determined whether IL 1Ra , as compared to IL 1beta , IL 10 , transforming growth factor ( TGF ) beta , and tumor necrosis factor ( TNF ) alpha , in the bronchoalveolar lavage fluid ( BALF ) from lung transplant recipients was associated with BOS . ^^^ Importantly , the elevated levels of IL 1Ra in the BOS and FBOS groups were not accompanied by any significant increases in IL 1beta , IL 10 , TGF beta , or TNF alpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The predominant cytokines expressed in response to all three phenotypes were interleukin 1 beta ( IL 1 beta ) , IL 1Ra , and IL 6 . ^^^ In response to the invasive strain , which induced severe corneal inflammation , significantly lower ratios of IL 1Ra to IL 1 beta were present at all time points , whereas corneas challenged with the CLARE strain , which induced very mild inflammation , showed a high ratio of IL 1Ra to IL 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
BACKGROUND : In temporomandibular joint ( TMJ ) arthritis , there is limited knowledge of the relationship between interleukin 1beta ( IL 1beta ) and interleukin 1 receptor antagonist ( IL 1ra ) , as well as the source of these cytokines . ^^^ From 6 h to 12 weeks after induction of arthritis , topology of IL 1beta and IL 1ra were observed . ^^^ In the early phase of the acute stage , infiltrating inflammatory cells , as well as synovial cells , produced IL 1beta and IL 1ra . ^^^ In this phase of arthritis , IL 1beta and IL 1ra did not appear to be produced by synovial cells . ^^^ From the early to intermediate phase of the chronic stage , proliferating synovial cells produced IL 1beta and IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 ( IL 1 ) consists of two molecules , IL 1 alpha and IL 1 beta , and IL 1 receptor antagonist ( IL 1Ra ) is a natural inhibitor of these molecules . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
While the IL 1beta levels did not deviate significantly from controls , the IL 1ra levels were significantly elevated in the WG patients throughout the study period ( p < 0 . 01 ) . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Significant elevations in TNF alpha , IL 1beta , interleukin 6 ( IL 6 ) , and IL 1ra resulted when HWB was exposed to E concentrations ( 10 ng / ml ) reported to circulate in heatstroke . ^^^ While E stimulated IL 1ra was significantly decreased by the presence of prior heat stress ( PPHS ) , E stimulated IL 1beta , TNF alpha , and IL 6 were not significantly altered by PPHS , but tended to be elevated . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Furthermore , the contents of mRNAs of IL 1alpha , IL 1beta and IL 1ra in the mucosa at the terminal ileum and recto sigmoid junctions were determined and compared using RT PCR method in 30 IBS patients and 12 controls . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To examine this , the influence of IL 1alpha 889 , IL 1beta 511 and IL 1Ra VNTR genotypes and IL 10 genotypes / haplotypes ( ACC , GCC and ATA ) on IL 10 plasma levels , and a putative correlation between IL 10 and IL 1alpha plasma levels were analysed . ^^^ The IL 10 , IL 1alpha , IL 1beta and IL 1Ra gene polymorphisms were analysed using PCR . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Some of these include HLA class 2 antigens , mannose binding lectin , alpha ( 1 ) antitrypsin and alpha ( 1 ) antichymotrypsin , glutathione S transferase , nitric oxide synthase type 1 , TNF alpha , TGF beta , IL 1beta and IL 1Ra . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Inflammatory gene expressions such as IL 1beta and TNF alpha are selectively repressed , while certain anti inflammatory genes such as secretory IL 1R antagonist are still induced in LPS adapted / tolerant cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In OA synovial membranes treated with LPS , IL 13 inhibited the synthesis of IL 1beta , TNF alpha and stromelysin , while increasing IL 1Ra production . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In a retrospective analysis of 179 recipients of thoracic organ transplants ( 128 heart ; 36 heart lung ; and 15 lung ) , polymorphisms in 8 genes that influence the inflammatory process , namely IL1B , IL1R1 , IL1RN , IL 6 , IL 10 , TNFA , TGFB 1 and FCGRIIA , were examined . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Our data indicate that CGA and IL 1RI are expressed by all seven , IL 1 beta by five , IL 1RII and IL 1RA by six lines . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The levels of IL 1Ra were undetectable in culture supernatants of untreated cells , but were significantly increased by IL 1beta . ^^^ Cell lysates contained very low levels of IL 1Ra , even in response to IL 1beta , suggesting that chondrocytes produce predominantly sIL 1Ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Production of IL 1beta and IL 1Ra as risk factors for susceptibility and progression of relapse onset multiple sclerosis . ^^^ Here , we show that families that are characterized by high IL 1beta over IL 1Ra production ratio are at 2 . 2 fold ( 95 % CI , 1 . 0 4 . 8 ; p=0 . 05 ) increased risk to have a patient relative with relapse onset MS than families with a low ratio . ^^^ Those families who combine a high IL 1beta over IL 1Ra ratio with a high tumor necrosis factor ( TNF ) over IL 10 production ratio have a 6 . 2 fold ( 95 % CI , 1 . 8 21 ; p=0 . 002 ) increased risk . ^^^ Innate production of IL 1beta and IL 1Ra is not related to the outcome of primary progressive MS . ^^^ Taq 1 polymorphism in the IL 1beta gene and the variable number of tandem repeats ( VNTR ) polymorphism of 86 base pairs within the IL 1Ra gene can not explain these findings . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Genotyping for IL 1alpha , IL 1beta and IL 1Ra single nucleotide polymorphisms ( SNPs ) performed in a cross sectional group of 312 consecutive RA patients ( RA group 1 ) and a cohort of 94 incident female RA patients ( RA group 2 ) revealed that the rare IL 1RN + 2017 C allele was significantly increased in RA compared to controls ( n = 245 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate whether interleukin 1 beta ( IL 1 beta ) exon 5 and IL 1 receptor antagonist ( IL 1Ra ) gene polymorphisms can be used as markers of susceptibility to febrile convulsions in children . ^^^ Polymorphisms for IL 1 beta exon 5 and IL 1Ra gene polymorphisms were detected by polymerase chain reaction . ^^^ Genotypes and allelic frequencies for IL 1 beta exon 5 and IL 1Ra gene polymorphisms in both groups were compared . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Moreover , IL 1Ra was not produced in large excess , as during peripheral inflammation but in a molar ratio to IL 1beta of 1 : 1 . ^^^ Intrahippocampal injection of IL 1beta worsened seizure activity , whereas IL 1Ra was a powerful anticonvulsant in various models of limbic seizures . ^^^ CONCLUSIONS : This study shows that limbic seizures in rodents rapidly and reversibly induce proinflammatory cytokines in glia and suggests that changes in the IL 1Ra / IL 1beta ratio in brain may represent an effective physiopathologic mechanism to control seizures . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE To investigate the characteristics and clinical value of serum tumor necrosis factor alpha ( TNF alpha ) and its receptor ( sTNF R ) , interleukin 1beta ( IL 1beta ) and its receptor ( IL 1R ) , interleukin 6 ( IL 6 ) and its receptor ( IL 6R ) in patients with pulmonary tuberculosis , and to evaluate their role in the immunopathogenesis of tuberculosis . ^^^ METHODS The serum levels of TNF alpha , sTNF R Iota IL 1beta , IL 1R , IL 6 and IL 6R were measured using the sandwich ABC ELISA method in 41 cases of active tuberculosis , 21 cases of inactive tuberculosis and 20 normal controls . ^^^ RESULTS The serum levels of TNF alpha sTNF RIota IL 1beta , IL 1R , IL 6 IL 6R and the TNF alpha / sTNF RIota ratio were significantly higher in both the active and the inactive tuberculosis groups than those in normal controls ( P < 0 . 01 approximately 0 . 05 ) . ^^^ The TNF alpha sTNF R Iota IL 1 beta , IL 1R , IL 6 IL 6R levels and the TNF alpha / sTNF R Iota ratio in the active tuberculosis group were significantly higher than those in the inactive tuberculosis ( P < 0 . 01 approximately 0 . 05 ) . ^^^ After 2 months ' antituberculosis treatment , the serum levels of TNF alpha , sTNF R Iota IL 1 beta , IL 1R , IL 6 , IL 6R and the TNF alpha / sTNF R Iota ratio in 15 ( 15 / 17 ) cases were significantly lower than those before treatment ( P < 0 . 01 approximately 0 . 05 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta , IL 1RA , and IL 4 gene polymorphisms were analyzed with polymerase chain reaction restriction fragment length polymorphism and polymerase chain reaction with sequence specific primers respectively . ^^^ There was not difference in the gene frequencies of IL 1beta , IL 1RA between UC patients and HS ( P > 0 . 05 ) . ^^^ The Chinese UC patients are not associated with IL 1beta and IL 1RA gene polymorphisms . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The aim of the present work was to investigate the expression of IL 1alpha , IL 1beta , IL 1ra , IL 1R1 , and IL 1R2 genes in equine cumulus cells and oocytes . ^^^ In conclusion , we demonstrated for the first time , in mares , the presence of IL 1beta and IL 1R2 transcripts in oocytes and of IL 1beta , IL 1ra , IL 1R1 , and IL 1R2 in cumulus cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Transduction of IL 1Ra or vIL 10 genes resulted in a significant reduction of IL 1beta both at the mRNA and at the protein level . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Plasma and peripheral blood mononuclear cell ( PBMC ) production of interleukin 1 beta ( IL 1beta ) , tumor necrosis factor alpha ( TNF alpha ) , interleukin 6 ( IL 6 ) , interleukin 1 receptor antagonist ( IL 1ra ) and soluble TNF receptor type 2 ( sTNFrII ) were measured at baseline and 2 , 6 , 24 and 168h following exercise . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : Interleukin 1beta ( IL 1beta ) , interleukin 1 receptor antagonist ( IL 1RA ) , interleukin 6 ( IL 6 ) , interleukin 10 , and tumor necrosis factor alpha plasma levels were measured with enzyme linked immunosorbent assay in 55 children with FSs and in 20 age matched febrile controls immediately on arrival at the hospital . ^^^ RESULTS : The plasma IL 1RA / IL 1beta ratio ( mean , 2 , 133 vs . 119 ; median , 790 vs . 105 ; p < 0 . 0001 ) and plasma IL 6 ( mean , 41 . 7 pg / ml vs . 16 . 1 pg / ml ; median , 19 . 6 pg / ml vs . 10 . 5 pg / ml ; p = 0 . 005 ) were significantly higher in FS patients compared with control children . ^^^ In this analysis , the high plasma IL 1RA / IL 1beta ratio was the most significant factor connected to FSs ( OR , 41 . 5 ; 95 % CI , 4 . 9 352 . 8 ) , but high plasma IL 6 also was significantly associated with FSs ( OR , 5 . 3 ; 95 % CI , 1 . 4 20 . 3 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : Peripheral blood mononuclear cells ( PBMC ) from 24 chronic asymptomatic smokers , and 28 controls , age and gender matched , were isolated and incubated in vitro with lipopolysaccharide ( LPS ) or phytohemagglutinin ( PHA ) to induce secretion of IL 1beta , IL 1ra , IL 6 , IL 10 , TNFalpha and IL 2 , respectively , from mononuclear cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
At 72 h the upregulated genes were IL1RA , IL2RG , CXCR 4 , SCYA 1 , SCYA 3 , SCYA 4 , SCYA 5 , SCYA 22 , ANX 2 , CD 83 and UPAR . cDNA array results were confirmed on randomly selected genes using quantitative real time polymerase chain reaction for three upregulated ( CXCR 4 , IL1B and CD 14 ) and three downregulated ( DEK , AF 4 and FLI 1 ) genes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Both in normal and inflammatory rats , the IL 1 beta induced antinociceptive effect was completely abolished by IL 1ra ( 50 ng , i . t . ) , and apparently attenuated by naloxone ( 10 microg , i . t . ) or mianserin ( 20 microg , i . t . ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Messages encoding macrophage inflammatory protein ( MIP ) 1beta , MIP 1alpha , MIP 2 , monocyte chemoattractant protein ( MCP ) 1 , interleukin ( IL ) 1alpha , IL 1beta , IL 1Ra , IL 6 , and Macrophage Migration Inhibitory Factor ( MIF ) were significantly elevated 24 hours post ozone followed by endotoxin as compared to exposure to ozone or endotoxin individually . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1 family consists of two agonists , IL 1alpha and IL 1beta , two receptors , biologically active IL 1RI and inert IL 1RII , and a specific receptor antagonist , IL 1Ra . ^^^ This association may be secondary to an imbalance in the IL 1 system with enhanced production of IL 1beta and reduced production of the major intracellular isoform of IL 1Ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To recover inflammatory molecules , tapes were extracted in buffered saline with sonication and the tape extracts analysed using commercial immunoassay methods for pro inflammatory cytokines [ i . e . interleukin 1alpha ( IL 1alpha ) , IL 1beta , IL 1 receptor antagonist ( IL 1ra ) , IL 8 and tumor necrosis factor alpha ( TNF alpha ) ] and the immunologic cytokines [ i . e . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
As to in vivo rates of adsorbing IL 1beta , IL 1Ra , IL 6 , IL 8 and TNF alpha before and after the use of column at the time of evaluation , the rates 5 min after the start were 31 . 4 , 39 . 3 , 36 . 4 , 76 . 2 and 71 . 6 % respectively . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Cytokines ( TNFalpha , IL 6 , IL 1beta , IL 10 , IL 1ra ) , complement split products ( C3d , C4d ) and coagulation system activation ( F 1 + 2 , ATIII ) were measured pre , peri and up to 48 h postoperatively . ^^^ There were no intergroup differences detectable for TNFalpha , IL 1beta , IL 1ra , complement and coagulation markers . ^^^ We conclude that MUF in itself does not significantly influence TNFalpha , IL 1beta , IL 1ra and the complement and coagulation profiles in children undergoing cardiac surgery with CPB . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Plasma and peripheral blood mononuclear cells ( PBMC ) were obtained from 55 healthy human volunteers , whose genotypes for four polymorphisms of IL 1 family genes ( IL1B , IL1R1 and IL1RN ) were determined by PCR . ^^^ IL 1beta and IL 1Ra production and release in PBMC cultures were studied by flow cytometry and ELISA . ^^^ IL1RN genotype also emerged as the principal regulator of both constitutive and stimulated IL 1Ra and IL 1beta release . ^^^ Allele IL1RN * 2 was consistently associated with higher IL 1Ra and lower IL 1beta release , in a dosage dependent manner . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We measured serum levels of cytokines ( IL 1B , IL 1Ra , IL 2 , IL 6 , TNF alpha ) , immunoglobulins ( IgG , IgE , IgM ) , fibrinogen . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The amounts of IL 1 beta released in vivo when added to cultures of embryonic DA neurons , did not significantly reduce the survival of DA neurons in vitro , and inclusion of the naturally occurring IL 1 receptor antagonist , IL 1ra , did not appear to affect the numbers of surviving DA neurons present after 5 days in vitro . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Pretreatment of supernatants from P . aeruginosa MC cocultures with neutralizing anti IL 1alpha plus anti IL 1beta Abs , or IL 1R antagonist before addition to HUVEC for stimulation completely abrogated MC induced PMN transmigration , while anti TNF alpha treatment had no effect . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RESULTS : Human DC co activated in vitro by CD40L and IL 1beta expressed numerous cytokine genes including IL 12beta , IL 23 p 19 , IL 1beta , IL 1alpha , IL 1Ra , IL 10 , IL 6 , IL 18 and IFN gamma . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Cytokine production was tested at the mRNA level by real time reverse transcriptase polymerase chain reaction for interleukin ( IL ) 10 , IL 1 receptor antagonist ( IL 1Ra ) , IL 1beta , tumor necrosis factor alpha , and IL 12p40 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Although there were no significant changes in IL 1beta , TNF alpha , and IL 8 serum levels during the observation period , there was a significant rise in IL 6 , IL 1ra , and sTNF RI concentrations in the entire group of patients between postoperative day 1 and 14 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Physical exertion is a stimulus for the upregulation of cytokine production including IL 1beta , IL 1ra , IL 2 , IL 4 , IL 6 , IL 10 and TNF alpha in horses . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
AIM : This study was conducted to investigate the effect of interleukin 1 receptor antagonist ( IL 1ra ) on the LPS induced interleukin 1beta ( IL 1beta ) synthesis in human dental pulp cells and to assess the role of IL 1ra in pulpal inflammation . ^^^ METHODS : IL 1beta from human dental pulp cells ( HDP ) was measured by sandwich ELISA ; IL 1ra expression in pulpal tissue was detected by immunohistochemical staining . ^^^ The addition of IL 1ra reduced FnLPS induced IL 1beta synthesis in human dental pulp cells . ^^^ Significant inhibition of the FnLPS induced IL 1beta synthesis was observed when IL 1ra was added before treating with FnLPS for 60 min . ^^^ CONCLUSIONS : IL 1ra could reduce LPS stimulated IL 1beta synthesis , suggesting that IL 1ra may play a role in pulpitis . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Other fecal cytokines ( IL 1beta and IL 1ra ) were found in increased concentrations ( P < 0 . 05 when at least one EAEC virulence factor was present compared with the concentrations when EAEC negative for multiple virulence factors was found in patients with diarrhea . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : In the present study , the effect of IL 1beta and IL 1ra on aromatase ( Arom ) activity and mRNA expression in human osteoblast like cells was investigated by [ ( 3 ) H ] water released upon the conversion of [ 1beta ( 3 ) H ] androstenedione to estrone and the reverse transcription polymerase cain reaction ( RT PCR ) method . ^^^ The experimental group is divided into four group : G 1 ( IL 1beta 1 microgram / L ) , G 2 ( 10 microgram / L ) , G 3 ( IL 1beta 10 microgram / L + IL 1ra 500 microgram / L ) and G 4 ( IL 1ra 500 microgram , / L ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : To determine the allele frequencies and genotype distribution of interleukin ( IL ) 1 alpha , IL 1 beta and IL 1 receptor antagonist ( IL 1ra ) gene polymorphism in septic patients . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To examine the role of IL 1 signaling in memory , we infused Long Evans rats intracerebroventricularly with IL 1beta ( 10 ng / rat ) , IL 1 receptor antagonist ( IL 1ra , 100 microg / rat ) , or saline immediately following a learning task and tested memory functioning 1 8 days later . ^^^ In the Morris water maze ( MWM ) , IL 1ra caused memory impairment in the hippocampus dependent , spatial version , whereas IL 1beta had no effect . ^^^ Neither IL 1beta nor IL 1ra influenced the hippocampus independent , nonspatial version of the MWM . ^^^ In the passive avoidance response , which also depends on hippocampal functioning , IL 1ra caused memory impairment , and IL 1beta caused memory improvement . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Moreover , pre elafin also significantly reduced mRNA levels of the three members of the IL 1 ligand family , namely IL 1alpha , IL 1beta and IL 1 receptor antagonist ( IL 1Ra ) , type 2 IL 1 receptor , and TNFalpha as assessed in whole lung tissue by RNase protection assay . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
ELISA ( protein level ) and RNAse protection assay ( mRNA level ) showed that SGE enhanced interleukin ( IL ) 1alpha , IL 1beta , IL 1Ra , IL 6 , and IL 12p40 cytokines , whereas production of IL 2 , IL 5 , IL 10 , and IL 13 was decreased . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Reversely , the immunogenic activity of monocytes ( IL 1beta versus IL 1ra production ) was higher in BA patients than in COPD patients . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : Since ulcerative colitis and Crohn ' s disease , which are associated with ankylosing spondylitis ( AS ) , have been found to be variably associated with the IL 1B and the IL 1RN genes encoding interleukin 1beta ( IL 1beta ) and the interleukin 1 receptor antagonist ( IL 1ra ) , we have investigated whether these polymorphisms in IL 1B and IL 1RN are also involved in AS . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The present study was undertaken to determine the relationship between mRNA expression levels of IL 1beta and its receptor antagonists ( secreted interleukin 1 receptor antagonist ( IL 1ra ) and intracellular IL 1ra ) in the synovium of the glenohumeral joint and shoulder pain in rotator cuff diseases , analyzing the synovial specimens by reverse transcriptase polymerase chain reaction . ^^^ The expression levels of the cytokine mRNAs were inversely correlated with the degree of pain ( IL 1beta : r = 0 . 930 ; secreted IL 1ra : r = 0 . 861 ; intracellular IL 1ra : r = 0 . 932 , P < 0 . 001 respectively ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
There was no significant difference in genotype and allele frequencies in IL 1beta exon 5 or interleukin 1 receptor antagonist ( IL 1ra ) polymorphisms between the studied groups , suggesting that the two polymorphisms may not be involved in the pathogenesis of severe malaria . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In patients of the PA + PCEA group in the postoperative period , production of IL 1beta , IL 6 , IL 1ra , and IL 10 was significantly less elevated , while IL 2 production was significantly less suppressed . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
PBMC were cultured 2 days under resting conditions , and interleukin 1 receptor antagonist ( IL 1ra ) , IL 1beta , soluble tumor necrosis factor receptor p55+75 ( sTNFR p55+p75 ) , and TNF a release into cell culture supernatants and corresponding serum cytokine levels were determined by specific ELISA . ^^^ RESULTS : Good ( ACR 50 70 ) or excellent ( ACR > 70 ) responses to MTX treatment were seen in groups of patients with a higher proportion of males ( 25 and 43 % ) associated with a significantly lower ratio of IL 1ra / IL 1beta ( p < 0 . 00001 ) constitutively produced by PBMC ( ratio < 100 ) compared with nonresponding ( ACR < 20 ) patients ( males 7 . 7 % ; ratio > 100 ) . ^^^ The decreased ratios of IL 1ra / IL 1beta in most good and excellent responders were due to an enhanced constitutive IL 1beta release from PBMC ( p < 0 . 004 ) compared to the groups of non or poor responders . ^^^ CONCLUSION : Determination of cellularly produced IL 1beta and even more of the IL 1ra / IL 1beta synthesis in PBMC may be useful to predict the outcome of RA patients undergoing treatment with MTX and may characterize a subset of RA that is more responsive to IL 1 directed therapeutic interventions . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The positive result of tetracycline hydrochloride treatment was accompanied by certain particularities in the dynamics of studied cytokines and receptors : the concentrations of IL 6 , IL 1 beta , TNF alpha dropped quicker and reached lower levels , and the concentrations of sIL 6R , IL 1RA , sTNFR 1 increased faster and reached higher maximum levels in the tetracycline treated groups . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Orbital fibroblasts , unlike those from skin , fail to express high levels of IL 1 receptor antagonist ( IL 1ra ) when treated with IL 1beta , leading to loss of modulation of IL 1 action . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1 beta level is elevated at the homozygous for IL 1RA , allele 2 ( IL 1RN * 2 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Here we report that the soluble form of the IL 1 receptor accessory protein ( AcP ) increases the affinity of binding of human IL 1alpha and IL 1beta to the soluble human type 2 IL 1 receptor by approximately 100 fold , while leaving unaltered the low binding affinity of IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin ( IL ) 1alpha , IL 1beta , IL 1 receptor antagonist ( IL 1ra ) , IL 2 , IL 6 , IL 8 , IL 10 , tumor necrosis factor alpha ( TNF ) , soluble TNF receptor type 1 ( sTNF R 1 ) , sTNF R 2 , and sCD 14 were measured by ELISA . 3 IL 1alpha and IL 1beta were not detectable in any of the tested groups . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Our aim was to investigate the correlations of the interleukin 1beta ( IL 1beta ) and interleukin 1 receptor antagonist ( IL 1Ra ) gene polymorphisms with bone mineral density ( BMD ) and their relationship to osteoporosis . ^^^ METHODS : The IL 1beta ( promoter and exon 5 ) and IL 1Ra ( intron 2 ) gene polymorphisms were determined using polymerase chain reaction . ^^^ RESULTS : The prevalence of each genotype of the interleukin 1 related genes in the study population was : ( 1 ) 14 % C / C , 71 . 5 % C / T , and 14 . 5 % T / T in IL 1beta promoter ; ( 2 ) 95 . 3 % E1 / E1 and 4 . 7 % E1 / E2 in IL 1beta exon 5 ; ( 3 ) 92 . 4 % I / I , 6 . 4 % I / II , and 1 . 2 % II / II in IL 1Ra intron 2 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In addition to IL 1beta , IL 6 , TNF alpha , and their receptors , LEW / N hypothalamic cells also transcribed more anti inflammatory molecules , IL 1RII , IL 1RA , and transforming growth factor ( TGFbeta 1 ) , than F334 / N cells . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 beta action is complex and regulated , in part , by its naturally occurring inhibitor , the IL 1 receptor antagonist ( IL 1ra ) . ^^^ Whether there was a temporal and spatial correlation between IL 1 beta and IL 1ra expression in , and release by , oxidized low density lipoproteins ( oxLDL ) stimulated human aortic smooth muscle cells ( HASMCs ) was determined by using ELISA and Western blot . ^^^ In addition , IL 1 beta and IL 1ra expression was detected in the neointima of endothelia denuded cholesterol fed New Zealand white rabbits by immunohistochemistry and Western blot . ^^^ Treatment with 20 microg / ml oxLDL resulted in increased IL 1 beta release after 6 h , which peaked at 24 h , and in increased IL 1ra release , first seen after 12 h , but continuing to increase for at least 48 h . ^^^ In cholesterol fed endothelia denuded rabbits , the notably thickened intima showed significant IL 1 beta and IL 1ra expression . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The study aim was to test whether interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1Ra ) , IL 4 or IL 10 gene polymorphisms could be used as markers of susceptibility or severity in MVP among the Chinese population in Taiwan . ^^^ IL 1beta promoter , IL 1beta exon 5 , IL 1Ra , IL 4 promoter , IL 4 intron 3 and IL 10 gene polymorphisms were identified by polymerase chain reaction based restriction analysis . ^^^ RESULTS : There was no significant difference in the distribution of genotypes and allelic frequencies between MVP cases and controls for IL 1beta promoter , IL 1beta exon 5 , IL 1Ra , IL 4 promoter , IL 4 intron 3 and IL 10 gene polymorphisms . ^^^ CONCLUSION : These findings suggest that the IL 1beta , IL 1Ra , IL 4 or IL 10 gene polymorphisms are not suitable genetic markers of MVP in Taiwan Chinese . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 beta was shown to induce a rapid and strong synthesis of IL 6 and IL 1ra in the pituitary but failed to regulate GH contents or release . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RESULTS : Compared with controls , asymptomatic patients had increased production of IL 1beta and IL 12 ( both P < 0 . 05 ) , unchanged production of TNF alpha , IFN gamma and IL 1ra and notably reduced production of IL 10 , IL 2 and sIL 2 ralpha ( all P < 0 . 05 ) . ^^^ HIV progression led to a progressive decline in whole blood culture production of TNF alpha , IFN gamma , IL 1ra , IL 1beta , IL 12 , IL 10 and IL 2 ( all P < 0 . 0001 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Injection of lipopolysaccharide ( LPS ) into the soft palate ( ISP ) of GLOx or sham operated ( SHAM ) rats increased the circulating levels of interleukin 1beta ( IL 1beta ) , interleukin 1 receptor antagonist ( IL 1ra ) and corticosterone ( CORT ) , as well the hypothalamic content of IL 1beta ; no difference in circulating levels and hypothalamic content was found between GLOx and SHAM at 2 and 4 . 5 h after LPS injection . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 receptor antagonist ( IL 1ra ) as well as anti IL 1beta antibody attenuated the influence of activated microglia on neuronal tau and synaptophysin , but anti TNFalpha antibody was ineffective . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Effects of plaque , psychological stress and gender on crevicular Il 1beta and Il 1ra secretion . ^^^ OBJECTIVES : The study aimed to analyse ( a ) whether the effects of psychological stress and of experimental gingivitis on interleukin 1beta ( Il 1beta ) described before are compensated by concomitant increases in Il 1 receptor antagonist ( Il 1ra ) , and ( b ) whether there do exist any gender differences in the Il 1 responses to experimental gingivitis and to psychological stress . ^^^ Weekly crevicular fluid samples of plaque and hygiene sites were assayed for Il 1beta and Il 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To evaluate this further , we measured expressions of interleukin 1beta ( IL 1beta ) and its receptor antagonist ( IL 1ra ) in these patients to provide additional evidence that the pathogenesis of PI IBS is underpinned by an inflammatory process . ^^^ IL 1beta and IL 1ra gene expressions were assayed by reverse transcriptase polymerase chain reaction , and their levels of expression were quantitated by optical densitometry after electrophoresis on agarose gel . ^^^ Despite these differential changes in IL 1beta mRNA expression , no significant changes were observed in IL 1ra mRNA expression among the three groups . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present work , epidermal growth factor ( EGF ; experiment 1 , n = 49 mares ) and interleukin 1beta and interleukin 1RA ( IL 1beta and IL 1RA , respectively ; experiment 2 , n = 80 mares ) were injected intrafollicularly to evaluate the influence of these factors on in vivo maturation of equine preovulatory follicles . ^^^ In experiment 2 , groups 3 and 4 were the same as in experiment 1 , but groups 1 and 2 were changed as follows : 1 ) IL 1beta group , i . f . injection of IL 1beta ( 2 ml ; 0 . 5 microg / ml ) plus i . v . injection of physiological serum ; 2 ) IL 1RA group , i . f . injection of IL 1RA ( 2 ml ; 0 . 5 microg / ml ) plus i . v . injection of physiological serum . ^^^ In contrast , IL 1beta injection into the dominant follicle induced in vivo oocyte maturation and the ovulation process whereas IL 1RA seemed to block these mechanisms . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Leptin stimulated IL 1 antagonist ( IL 1Ra ) , IL 1beta secretion and expression of IL 1 receptor type 1 ( IL 1R tI ) in both cell types . ^^^ IL 1beta and IL 1Ra secretion were down regulated by IL 1R tI blockade using specific antibodies . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To investigate these interactions , we have evaluated changes in regional fat distribution , by DEXA , and the role of circulating cortisol , leptin , IL 1beta , and IL 1 receptor antagonist ( IL 1Ra ) , in relation to these changes , in 27 ( 19 DEXA ; 27 serum measurements ) patients with CS , before and after surgical treatment ( mean follow up , 31 months ; range , 5 80 ) , and compared them with measurements of age , sex , and body mass index matched healthy controls ( also obtained longitudinally ) . ^^^ These changes in CS patients were paralleled by decreases in cortisol , leptin , and IL 1Ra , whereas IL 1beta increased . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In 24 hour interval we assessed plasma levels of : PCT , TNF alpha , IL 1 beta , IL 1ra , IL 6 , IL 8 , sIL 2R and a spectrum of APP . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
This study describes the tissue expression of the cytokine interleukin 1 ( IL 1 ) alpha , IL 1 beta and its specific membrane receptor , IL 1 receptor type 1 ( IL 1R tI ) in a placental cartilaginous fish , the smoothhound shark , Mustelus canis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Serial measurements of the proinflammatory IL 6 and IL 1beta and the anti inflammatory IL 10 and IL 1ra were used . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To understand the dynamics of the intraarticular acute inflammatory phase of an anterior cruciate ligament ( ACL ) injured knee , we analyzed the level of inflammatory cytokines ( TNF alpha , IL 1beta , IL 6 , IL 8 , IL 1ra , and IL 10 ) in joint fluid samples aspirated from 34 knees following an acute ACL injury . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 is a pro inflammatory cytokine consisted of two molecular species , IL 1alpha and IL 1beta , and the IL 1 receptor antagonist ( IL 1Ra ) is a natural inhibitor of both molecules . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
This study demonstrates that stimulation of synaptosomes with IL 1ra in vitro , mimicked the effects of IL 1 beta by decreasing glutamate release and increasing JNK phosphorylation . ^^^ These effects of IL 1ra , but not IL 1 beta , were maintained in IL 1 type 1 receptor ( IL 1RI ) defective mice . ^^^ IL 1 beta blocked these IL 1ra induced effects suggesting that it may also act independently of IL 1RI in some circumstances . ^^^ Furthermore , IL 1ra mimicked the inhibitory effect of IL 1 beta on long term potentiation ( LTP ) in the hippocampus . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The NO donor , SNAP , augmented the secretion of TNF alpha , IL 6 and IL 1 beta ( by 62 % , 52 % and 175 % , respectively ) and decreased the release of IL 1 receptor antagonist ( IL 1Ra , by 34 % ) by the inflamed mucosa . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We tested whether two cytokine polymorphisms in the interleukin 1beta ( IL 1beta ) and IL 1 receptor antagonist ( IL 1ra ) genes , known to determine cytokine secretion , are associated with clinical manifestations and outcome of ANCA associated vasculitides . ^^^ METHODS : Polymerase chain reaction and restriction fragment length polymorphism analyses were performed to determine polymorphisms in the IL 1beta and IL 1ra genes in 79 patients with PR 3 ANCA , 30 patients with MPO ANCA vasculitis , and 196 healthy controls . ^^^ RESULTS : The frequency of the so called proinflammatory genotype , characterized by high secretion of IL 1beta and low secretion of its antagonist IL 1ra , was increased significantly in patients with PR 3 ANCA with end stage renal disease . ^^^ CONCLUSION : Patients with a renal manifestation of PR 3 ANCA vasculitis have an increased risk for developing end stage renal disease when carrying the proinflammatory IL 1beta / IL 1ra genotype . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interestingly , intra articular expression of the IL 1Ra transgene was found to increase in relation to the number of IL 1beta ( + ) cells injected . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta and IL 1ra were quantified using new commercially available ELISA kits ( Quantikine ) , and could be detected in all samples . ^^^ Significance levels of P < 0 . 05 were found for comparisons of healthy vs . deep bleeding and deep non bleeding sites for IL 1beta and IL 1ra in smokers , before adjustments for multiple testing . ^^^ P < 0 . 05 for the correlation between IL 1beta and IL 1ra at healthy sites in smokers only . ^^^ CONCLUSIONS : A decreased concentration of IL 1beta and also IL 1ra was found in GCF from periodontitis sites compared to healthy sites in smokers and in non smokers , although this did not reach statistical significance following adjustments for multiple testing . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1B encoding IL 1 beta is located on chromosome 2q14 , along with IL 1A encoding IL 1 alpha and IL 1RN encoding IL 1Ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Analysis of the cytokine pattern at 8h after infection by a macro gene array and RT PCR analysis showed that out of 24 different cytokines analyzed only IL 1ra , IL 10 , and TNF alpha were increased in the human skin following infections with S . mansoni and S . haematobium , whereas , after infection with S . japonicum there was significant increases in IL 1beta , IL 1ra , IL 2 , IL 6 , IL 8 , IL 10 , IL 15 , IL 18 , and TNF alpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In addition , IL 1Ra and IL 1beta plasma levels were quantified by ELISA in 130 randomly selected subjects . ^^^ IL 1Ra plasma levels showed an age related increase , whereas IL 1beta plasma levels did not show any detectable age related trend . ^^^ Neither IL 1Ra nor IL 1beta plasma levels showed any relationship with genotypes of the three IL 1 genes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Concentrations of interleukin ( IL ) 1alpha , IL 1beta , IL 6 , tumour necrosis factor ( TNF ) alpha and IL 1 receptor antagonist ( IL 1Ra ) were measured by sandwich ELISA . ^^^ Basal levels of IL 1alpha , IL 1beta , and TNF alpha were significantly increased following ovulation , while there was no significant change in levels of secretion of IL 6 or IL 1Ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin ( IL ) 1 gene polymorphisms : relevance of disease severity associated alleles with IL 1beta and IL 1ra production in multiple sclerosis . ^^^ Extending this observation , we investigated whether IL 1beta and IL 1ra production differed depending on carriership of this gene combination . ^^^ In whole blood , in vitro IL 1beta and IL 1ra production was determined by enzyme linked immunosorbent assay after 6 and 24 h of stimulation with lipopolysaccharide . ^^^ In patients , Il 1ra production was higher and IL 1beta production lower compared with controls . ^^^ In primary progressive patients , the IL 1beta / IL 1ra ratio was significantly lower than in relapsing remitting patients . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The levels of serum TNF alpha , IL 1Ra , IL 6 , and IL 1beta were dramatically reduced and remained at low levels throughout the isolation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The interleukin 1 ( IL 1 ) gene family includes three members ( IL 1 alpha , IL 1 beta and IL 1Ra ) that mediate immune and inflammatory responses through two specific cell surface receptors . ^^^ Cytosine to thymine transitions at codons 889 and 511 in the IL 1 alpha and IL 1 beta genes , respectively , and an 86 base pair repeat in the IL 1Ra are believed to influence gene transcription . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
LPS induced MIP 1alpha , MIP 1beta , IL 8 , IL 1beta , and IL 1Ra mRNA production , which was delayed by 1 hr and reduced twofold by IC 14 treatment . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present study , roles of tumor necrosis factor alpha ( TNFalpha ) and interleukin 1 beta ( IL 1beta ) in mediating lipopolysaccharide ( LPS ) induced brain injury were investigated by co administration of LPS with IL 1 receptor antagonist ( IL 1ra ) or TNFalpha antibody in the 5 day old rat brain . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta induced release of IL 6 and activated NFkappaB , p 38 , JNK and ERK1 / 2 in mixed glial cultures , which was completely abolished in the presence of IL 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The levels of IL 1alpha , IL 1beta and IL 1Ra were higher in homogenates of testicular tissue from sexually immature than those from mature mice . ^^^ Our results demonstrate , for the first time , the expression of IL 1beta in germ and Sertoli cells , and IL 1Ra in Leydig / interstitial cells of testicular tissues from adult and sexually immature mice , under in vivo conditions . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The current investigation determined conceptus and endometrial changes in gene expression for IL 1beta , IL 1 receptor antagonist ( IL 1Rant ) , IL 1 receptor type 1 ( IL 1RT1 ) , and IL 1 receptor accessory protein ( IL 1RAP ) in developing peri and postimplantation conceptuses as well as uterine endometrium collected from cyclic and pregnant gilts . ^^^ IL 1beta gene expression in porcine conceptuses was temporally associated with an increase in endometrial IL 1RT1 and IL 1RAP gene expression in pregnant gilts . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RESULTS : We demonstrated that interleukin 1beta ( IL 1beta ) , interleukin 1 receptor 2 ( IL 1R2 ) and interleukin 1 receptor antagonist ( IL 1RA ) genes are expressed in equine granulosa cells . ^^^ We observed that the IL 1beta and IL 1RA mRNA content changed in granulosa cells during the terminal follicular maturation whereas IL 1R2 mRNA did not vary . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To evaluate the contribution of IL 1 signaling to the brain pathology of schizophrenia , we measured protein and / or mRNA levels for IL 1beta and endogenous IL 1 receptor antagonist ( IL 1RA ) in the postmortem brain tissues of prefrontal and parietal cortex , putamen , and hypothalamus . ^^^ Both protein and mRNA levels of IL 1RA were specifically decreased in the prefrontal cortex of schizophrenic patients , whereas IL 1beta levels were not significantly altered in all the regions examined . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Control and patient peripheral blood mononuclear cells ( PBMC ) were incubated with IL 1beta , IL 10 , TGF beta or LPS for 20 h and the in vitro basal and stimulated secretions of IL 6 , TNF alpha , IL 1beta and IL 1ra were measured by ELISA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : Cultured immortalized rabbit lacrimal gland acinar cells were incubated with IL 1beta , iNOS inhibitor , or IL 1 receptor antagonist ( IL 1ra ) . ^^^ IL 1beta induced NO production was significantly antagonized by co incubation with IL 1ra or the iNOS specific inhibitor , 1400W . ^^^ IL 1ra greatly reduced IL 1beta induced iNOS expression . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Genetic polymorphisms in proinflammatory cytokines , the interleukin 1 ( IL 1 ) family ( IL 1beta and IL 1ra ) and tumor necrosis factor alpha ( TNF alpha ) , were studied in 274 Japanese patients with chronic HCV infection and 55 healthy individuals using standard polymerase chain reaction based genotyping techniques . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
All subjects underwent plasma insulin , glucose , interleukin 6 ( IL 6 ) , interleukin 10 ( IL 10 ) , interleukin 1 beta ( IL 1 beta ) , interleukin 1 receptor antagonist ( IL 1ra ) , C reactive protein , and tumor necrosis factor alpha ( TNF alpha ) levels determination . ^^^ RESULTS : After adjusting for age , sex , insulin resistance syndrome score , and severity of carotid atherosclerosis , serum IL 1 beta ( P < . 001 ) , IL 1ra ( P < . 005 ) concentration and the insulin resistance syndrome score ( P < . 001 ) were the only predictors of diastolic BP . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We have previously described the expression of interleukin cytokines ( IL ) 1alpha , IL 1beta , and IL 1 receptor antagonist ( IL 1ra ) in human breast cancer ( HBC ) tissue . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : We incubated human whole blood with CA beads at 37 degrees C for up to 2 h and measured tumour necrosis factor alpha ( TNF alpha ) interleukin 1beta ( IL 1beta ) and IL 1 receptor antagonist ( IL 1ra ) produced by leucocytes . ^^^ RESULTS : CA beads induced significant release of IL 1ra from leucocytes , but not TNF alpha or IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
PURPOSE : To evaluate the expression of interleukine 1 family including interleukin 1 , ( IL 1 alpha ) , interleukin 1 beta ( IL 1 beta ) , interleukine 1 receptor antagonist , ( IL 1RA ) and interleukine 1 beta precursor by the epithelium in pterygium so as to understand the pathogenesis of this disorder . ^^^ Of 10 pterygia , 7 pterygias were stained by IL 1 alpha and IL 1 beta in the full thickness of epithelium , IL 1 beta precursor and IL 1RA in the superior cell and with strong staining compared to control group , 3 of them showed the similar staining pattern with normal conjunctiva . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In parallel experiments , cultures were stimulated with LPS in the presence or absence of mevastatin and the release of IL 1beta and IL 1Ra was measured by ELISA . ^^^ Stimulation with LPS revealed that mevastatin treated monocytes retained the high IL 1beta output characteristic of undifferentiated cells ; conversely , IL 1Ra release was inhibited . ^^^ Concurrent treatment with mevalonolactone prevented the induction of apoptosis and suppressed both IL 1beta and IL 1Ra release in response to LPS , suggesting a rate limiting role for HMG CoA reductase in monocyte differentiation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OVA evoked hypersensitivity was partially inhibited ( about 51 % ) by pretreatment with anti TNFalpha , IL 1beta and IL 8 sera or with IL 1 receptor antagonist ( IL 1ra ) , but not anti NGF serum . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Control immunostaining for IL 1Ra in injured vessels localized IL 1beta and the endogenous inhibitor in the endothelium and inflammatory cells of the adventitia in IL 1Ra+ / + but not IL 1Ra / mice . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
While depolarizations in response to IL 1beta were abolished by treatment of cells with the IL 1 receptor antagonist ( IL 1ra ) , hyperpolarizations were still observed . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We found no association between serum IL 1beta level and age , sex , consumption of cardioactive drugs and serum levels of IL 1Ra , IL 6 , sIL 6R , IL 10 and TNF alpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1 gene cluster on chromosome 2ql4 contains three related genes ( IL 1alpha , IL 1beta , and IL 1 receptor antagonist , IL 1ra ) located within a 430 kb region . ^^^ Polymorphisms in the genes encoding IL 1alpha , IL 1beta , and IL 1ra have been associated with several inflammatory diseases . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In this study , 5 proinflammatory cytokines ( IL 1beta , IL 6 , TNF alpha , IFN gamma and IL 1 receptor antagonist , IL 1ra ) present in colostrum were tested for their potential to enhance mitogenic response and to elicit expression of IL 2 mRNA and CD 25 in peripheral blood mononuclear cells ( PBMC ) from newborn calves before being fed colostrum . ^^^ Pretreatment of PBMC from newborn calves with IL 1beta , TNF alpha or IFN gamma significantly enhanced the ConA response , whereas IL 1ra inhibited the response . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The expression of IL 1beta was significantly decreased in the ankle joints of mice treated with IL 1Ra ( P < 0 . 01 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
This review will focus on the intracerebral production of the pro and anti inflammatory cytokines interleukin IL 1beta , IL 1 receptor antagonist ( IL 1ra ) , IL 6 and TNF alpha in dementia , and their relation to gene polymorphism , to cerebral neuronal damage , apoptosis , and to clinical variables of dementia . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Despite strong IL 1ra expression , the IL 1ra / IL 1beta ratio , which is an indicator of inflammatory balance , was 41 % at day 1 in irradiated compared with control tissue . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Analysis based on polymerase chain reaction was used to resolve the 2 IL 1beta polymorphisms and the IL 1Ra intron 2 polymorphism . ^^^ The distributions of the other 2 polymorphisms , IL 1beta promoter 511 and IL 1Ra intron 2 , were not significantly different between the POAG patients and the healthy control group . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Polymorphisms of the IL 1alpha , IL 1beta and IL 1Ra genes have been implicated in a number of autoimmune or inflammatory conditions , with polymorphism of the IL 1Ra gene showing association with severity of graft versus host disease ( GVHD ) after allogeneic bone marrow transplantation ( BMT ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interaction between IL 1beta and interleukin 1 receptor antagonist ( IL 1ra ) plays a significant role in the regulation of inflammatory responses . ^^^ We studied levels of urinary excretion of IL 1beta and IL 1ra in patients with IgAN and HSN . ^^^ METHODS : Amounts of IL 1beta and IL 1ra excreted in 24 h urine samples collected from 241 IgAN , 26 HSN patients and from 33 healthy controls were determined . ^^^ In both patients and controls women had significantly higher IL 1ra , IL 1beta excretion levels and IL 1ra / IL 1beta ratios . ^^^ Excretion of IL 1beta or IL 1ra did not correlate with excretion of urinary protein , duration of the disease or any histopathological variable . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Sera from RA patients were assayed for interleukin 6 ( IL 6 ) , IL 1 beta , IL 10 , tumor necrosis factor alpha ( TNF alpha ) and IL 1 receptor antagonist ( IL 1ra ) . ^^^ Moreover , serum IL 1ra levels correlated significantly with serum IL 6 , IL 1 beta , and TNF alpha concentrations ( p = 0 . 005 , 0 . 008 , or 0 . 040 , respectively ) , but not with IL 10 ( p = 0 . 582 ) in RA patients . ^^^ The correlation of serum IL 1ra levels with serum IL 6 , IL 1 beta , or TNF alpha concentrations , and the borderline correlation of the former with CRP levels , demonstrate that IL 1ra is an acute phase reactant in RA as well as in SLE patients . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Imbalanced secretion of IL 1beta and IL 1RA in Chlamydia pneumoniae infected mononuclear cells from COPD patients . ^^^ Compared to the control group , release of its anti inflammatory counterpart IL 1RA was diminished in COPD patients , resulting in a significantly higher IL 1beta / IL 1RA ratio in C . pneumoniae infected AMs and PBMCs from COPD patients . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
However , there are substantial differences in the loop conformations , structures that confer binding specificity for the cognate receptor to IL 1beta and the antagonist IL 1Ra . ^^^ The structure IL 1F5 lacks features that confer antagonist properties on IL 1Ra , and we predict that like IL 1beta it will act as an agonist . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
ATL146e reduced the induction of IL 6 , IL 1beta , IL 1ra , and TGF alpha mRNA in WT > WT mice but not in A2A KO > WT mice . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
These sections were incubated with antibodies against cytokines IL 1alpha , IL 1beta , IL 1ra , TNFalpha , IFNgamma , IL 2 in all patients and TGFbeta 1 , 2 , 3 in 16 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
During experimental RV infection in healthy subjects , increased levels of the pro inflammatory mediator IL 1beta and the anti inflammatory IL 1 receptor antagonist ( IL 1ra ) have been found in nasal lavage . ^^^ METHODS : We determined IL 1ra , IL 1beta , and IL 8 in nasal lavages ( days 2 , 3 , and 6 ) of non asthmatics and asthmatics ( with and without pre treatment with the inhaled steroid budesonide ) before and after experimental RV 16 infection ( days 0 and 1 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The present study was performed to clarify this inhibitory effect of IL 1 beta by testing increasing concentrations of IL 1 beta , and by measuring the effect of addition of IL 1 receptor antagonist ( IL 1RA ) to the culture medium . ^^^ In Expt 3 , three different media were tested : medium 1 ( TCM199+BSA+eLH ) ; medium 2 ( medium 1+50 ng IL 1RA ml ( 1 ) ) ; and medium 3 ( medium 2+50 ng IL 1 beta ml ( 1 ) ) . ^^^ In Expt 5 , three different media were tested : medium 1 ( TCM199+BSA+EGF ) ; medium 2 ( medium 1+50 ng IL 1 beta ml ( 1 ) ) ; and medium 3 ( medium 2+50 ng IL 1RA ml ( 1 ) ) . ^^^ In Expt 2 , the presence of IL 1RA in the culture medium inhibited the effect of IL 1 beta and restored the rate of oocyte maturation ( P < 0 . 05 ) observed in the presence of LH alone . ^^^ The use of IL 1RA inhibited these effects , demonstrating that the action of IL 1 beta is receptor mediated . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
V . rhIL 1beta or CRF and ( 4 ) in rats treated with central IL 1beta and CRF plus alpha helical CRF and IL 1ra , respectively ( cross antagonism reaction ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Likewise , there was no significant alteration in either apoptotic frequency or the mRNA levels of 10 apoptotic related molecules in FGF 1 or VEGF treated tumors . mRNA expression for MCP 1 , IL 1 beta , IL 18 , and IL 1Ra , however , were decreased in the tumors following FGF 1 or VEGF treatment . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Association between IL 1beta 511C / T and IL 1RA ( 86bp ) n repeats polymorphisms and schizophrenia . ^^^ It has been established that cytokines play a critical role in the regulation of the CNS and recent studies have suggested that dysfunctions of both pro inflammatory ( IL 1beta , IL 6 , and TNF alpha ) and anti inflammatory ( IL 1RA and IL 10 ) cytokines could be involved in the pathophysiology of schizophrenia . ^^^ Therefore , the aim of the present study was to explore the possible role of the IL 1beta 511C / T and IL 1RA ( 86bp ) ( n ) repeats polymorphisms in schizophrenia . ^^^ The frequencies of IL 1beta 511C and IL 1RA allele 1 ( 86bp ) ( 4 ) are significantly higher in schizophrenic patients compared to controls ( IL 1beta 511 P=0 . 047 ; IL 1RA ( 86bp ) ( n ) P=0 . 002 ) . ^^^ Moreover our data show a protective effect of the IL 1RA allele 2 ( 86bp ) ( 2 ) against schizophrenia ( OR=0 . 59 95 % CI : 0 . 388 0 . 910 ; P=0 . 016 ) and this effect is enhanced by the concomitant presence of IL 1beta 511T ( OR=0 . 48 95 % CI : 0 . 30 0 . 76 ; P=0 . 002 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interestingly , both , the IL 1beta and TNFalpha effect could be blocked by IL 1ra , indicating that also the TNFalpha induced RGS 16 expression is mediated by IL 1 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Significant changes in inflammatory cytokines / chemokines ( IL 1beta , TNFalpha , IL 1ra , IL 6 , and MIP 1beta , MCP 1 ) were observed following each manipulation , but qualitative and quantitative differences were seen . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
PURPOSE : The aim of this study was to investigate whether interleukin 1beta ( IL 1beta ) , interleukin 1 receptor antagonist ( IL 1ra ) , or soluble IL 1 receptor 2 ( sIL 1RII ) in synovial fluid or plasma is associated with joint pain or signs of tissue destruction in patients with temporomandibular joint ( TMJ ) involvement of polyarthritides . ^^^ TMJ synovial fluid samples and plasma were obtained for analysis of IL 1beta , IL 1ra , and sIL 1RII . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Spleen cells from mice undergoing withdrawal also had decreased splenic mRNA and / or protein levels of IL 1beta , IL 1Ra , TNF alpha , IL 12 , and IFN gamma . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Here , we show that a continuous delivery of a low , but steady state level of the naturally occurring IL 1 receptor antagonist ( IL 1Ra ) reduced inflammatory responses and inhibited tumor development in mice , phenomena that are induced by IL 1 , mainly secretable IL 1beta . ^^^ The proangiogenic features of IL 1beta were manifested at low levels of the cytokine , and release of 25 ng per day of the IL 1Ra was needed to oppose its effects and inhibit tumor development . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : Sprague Dawley rats were randomly assigned to 12 groups and given continuous intracerebroventricular ( ICV ) infusions of IL 1beta , the IL 1 receptor antagonist ( IL 1ra ) , or saline vehicle ( control ) . ^^^ Prolonged administration of the antagonist IL 1ra resulted in significant increases in CBF compared with that in both IL 1beta treated animals and controls . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interaction of IL 1beta to its specific receptor interleukin 1 receptor type 1 ( IL 1RI ) leads to nuclear factor kappa B ( NuFkappaB ) nuclear translocation and a robust transcriptional activation of inhibitor of kappa B alpha ( IkappaBalpha ) within the rat brain . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : Preterm labor in experimental models is initiated by intra amniotic interleukin 1beta ( IL 1beta ) and inhibited by interleukin 1 receptor antagonist ( IL 1ra ) . ^^^ The IL 1ra gene is polymorphic and the different alleles are associated with variations in IL 1beta and IL 1ra production . ^^^ The relationship among the IL 1ra genotype of the fetus , concentrations of IL 1beta and IL 1ra in second trimester amniotic fluid , and pregnancy outcome was determined . ^^^ STUDY DESIGN : Amniotic fluids from 291 consecutive women with singleton pregnancies , obtained at 15 to 17 weeks ' gestation , were tested for IL 1beta and IL 1ra concentrations by enzyme linked immunosorbent assay . ^^^ Fetal possession of IL1RN * 2 was associated with a greater than 50 % increase in midtrimester intra amniotic IL 1beta levels ( P= . 006 ) and a smaller increase in IL 1ra levels ( P= . 01 ) compared with fetuses who were IL1RN * 1 homozygotes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Serial measurements of the cytokines tumor necrosis factor ( TNF ) alpha , interleukin ( IL ) 1alpha , IL 1beta , IL 6 , and IL 10 and the cytokine inhibitors soluble TNFalpha receptor type 1 ( sTNFalphaRI ) , IL 1 receptor antagonist ( IL 1Ra ) and soluble IL 1 receptor 2 ( sIL 1RII ) were performed on the NBL fluid and matching plasma samples by ELISA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Pre treatment with Il 1ra ( 250 microg ) blocked all the effects of Il 1beta and the excitatory effects of leptin on type 1 units , whereas it enhanced the inhibitory effects of leptin on type 2 units . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Serum levels of proinflammatory cytokines , interleukin 1 beta ( IL 1beta ) , tumor necrosis factor alpha , ( TNF alpha ) , and their inhibitors , IL 1 receptor antagonist ( IL 1ra ) and soluble TNF receptor 1 ( sTNFR 1 ) , were determined by enzyme linked immunosorbent assay in 104 patients with Behet ' s disease ( 65 active , 39 inactive ) and 40 healthy controls . ^^^ The levels of IL 1beta and IL 1ra were significantly higher in both active and inactive patients than in control subjects ( P < 0 . 01 and P < 0 . 01 , respectively ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The present experiments were carried out on 71 non pregnant and 181 pregnant Sprague Dawley rats to determine if basal levels of the endogenous antipyretic substance , interleukin 1 receptor antagonist ( IL 1ra ) , change relative to interleukin 1beta ( IL 1beta ) throughout gestation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the patterns of tumor necrosis factor alpha ( TNF alpha ) , interleukin 1beta ( IL 1beta ) , IL 6 , interferon gamma ( IFN gamma ) and interleukin 1 receptor antagonist ( IL 1Ra ) during the course of dengue shock syndrome . ^^^ MEASUREMENTS : The plasma concentration and the ex vivo production , with and without lipopolysaccharide ( LPS ) , of TNF alpha , IL 1beta and IL 1Ra were measured in duplicate by nonequilibrium radioimmunoassay ( RIA ) ; IFN gamma and IL 6 were measured by ELISA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Our study identifies eight genes ( IL 1beta , IL 1RA , macrophage inflammatory protein 1beta , monocyte chemoattractant protein 1 , CC chemokine receptor ( CCR ) 1 , CCR 2 , CCR 5 , and F4 / 80 ) that are highly expressed in all of our experimental groups . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IFNbeta may owe its anti inflammatory property to its ability to induce interleukin 1 receptor antagonist ( IL 1Ra ) without triggering IL 1beta synthesis in human monocytes . ^^^ Here we compare modulatory effects of IFNbeta on the production of proinflammatory cytokines ( IL 1beta , IL 1alpha , TNF , and IL 6 ) and IL 1Ra in human monocytes stimulated by lipopolysaccharides ( LPS ) and isolated plasma membranes of stimulated T cells ( msHUT ) , which are likely to reflect monocyte activation in acute and chronic inflammation , respectively . ^^^ IFNbeta inhibited the expression ( mRNA ) and production ( protein ) of IL 1beta and TNF , while enhancing those of IL 1Ra in monocytes activated by msHUT . ^^^ In contrast , in monocytes activated by LPS , IFNbeta enhanced the expression and production of IL 1beta , TNF , and IL 1Ra , suggesting that it did not display anti inflammatory properties in these conditions . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
I / R injury causes induction of hepatic transcripts for IL 1alpha , IL 1beta , IL 1Ra , IL 6 , IL 10 , IL 18 , INF beta , INF gamma , regulated on activation , normal T cell expressed , and presumably secreted ( RANTES ) , major intrinsic protein ( MIP ) 1alpha , MIP 2 , IFN gamma inducible protein ( IP ) 10 , and monocyte chemotactic protein ( MCP ) 1 that are suppressed by administering ATL146e to wild type but not to A ( 2A ) AR knockout mice . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The results indicated that IL 1Ra or vIL 10 gene transfer significantly inhibited IL 1beta and tumor necrosis factor ( TNF ) expression at both mRNA and protein levels . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Homogenates of rectal biopsies from 99 UC and 54 controls were assayed for cytokines IL 1ra , IL 1a and IL 1b using ELISA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We have analysed transcripts of IL 1 gene system ( IL 1alpha , IL 1beta , IL 1RI , IL 1RII and IL 1RA ) to evaluate the possible link between the level of gene ( s ) transcription and their function . ^^^ Looking more closely at gene ( s ) differential expression it appears that IL 1alpha can be preferentially down regulated by IL 1RA gene in intratubular fraction while the IL 1beta , through the `` false ' ' IL 1RII receptor in the interstitium . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : By detecting the expression of IL 1RI and TGF beta ( 1 ) on the normal rat cornea and graft , and the amount of IL 1 beta in the aqueous humor of normal rat eye and the eye after keratoplasty , to investigate the relationship between these cytokines and graft rejection and to observe the effects of IL 1 receptor antagonist ( IL 1ra ) on graft rejection . ^^^ The keratoplasty graft rejecting reaction can be reduced and mean survival time can be prolonged by IL 1ra , which inhibits the expression of IL 1RI and TGF beta ( 1 ) and decreases the level of IL 1 beta in the aqueous humor . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
An IL 1 receptor antagonist ( IL 1RA ) inhibited the stimulatory effects of IL 1beta on these transcription factors by as much as 78 % . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 ( IL 1 ) receptor antagonist ( IL 1ra ) , IL 1beta , IL 6 , tumor necrosis factor alpha ( TNF alpha ) , and plasma proteins were measured daily . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Additional typing for IL1A , IL1B , IL1R1 , IL1RN , and TGFB 1 SNPs also failed to demonstrate any influence on HIV 1 infection or virologic / immunologic control in more selected patient groups . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RESULTS : The maternal serum that was utilized to supplement the embryo media was found to have measurable amounts of IL 1beta and IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the presence of all of these cytokines , anti IL 6R mAb eliminated the synergistic effect of IL 6 , IL 1beta , and TNFalpha , while IL 1Ra or anti TNFalpha mAb did not . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The present study was undertaken to determine whether mRNAs for IL 1alpha , IL 1beta , and IL 1 type 1 receptor ( IL 1R ) are expressed in bovine corpora lutea ( CL ) , and whether luteal cells respond to treatment with IL 1alpha and IL 1beta during the luteal phase . ^^^ IL 1alpha , IL 1beta , and IL 1R mRNAs were detected by reverse transcription polymerase chain reaction ( PCR ) in all luteal stages examined . ^^^ When developing , mid , and late luteal cells were treated with IL 1alpha ( 1 30 ng / ml ) or IL 1beta ( 1 30 ng / ml ) for 24 h , IL 1alpha and IL 1beta dose dependently increased prostaglandin ( PG ) F ( 2alpha ) and PGE ( 2 ) production by the luteal cells of all stages ( P < 0 . 05 ) , indicating the presence of functional IL 1R in bovine CL . ^^^ Overall results indicate that genes for IL 1alpha and IL 1beta are expressed and a functional IL 1R is present in the bovine CL throughout the luteal phase , and suggest that IL 1alpha and IL 1beta have different roles as local modulators to regulate PGF ( 2alpha ) and PGE ( 2 ) production during the luteal phase . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The cytokine IL 1 receptor antagonist ( IL 1Ra ) is the competitive inhibitor of the IL 1 agonists IL 1alpha and IL 1beta . ^^^ In this study , we observed that possession of particular alleles of 5 IL 1 gene polymorphisms ( IL1A 889 , IL1Alpha VNTR , IL1B 511 , IL1B +3953 and the IL1RN VNTR ) did not correlate with higher plasma IL 1Ra levels . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RESULTS : Self rated health correlated with levels of IL 1beta ( r = 0 . 27 ; p < . 001 ) , IL 1ra ( r = 0 . 19 ; p < . 05 ) and TNF alpha ( r = 0 . 46 ; p < . 001 ) in women but not in men . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1ra had no effect on basal proinflammatory cytokines , but completely blocked the stress induced enhancement in central and pituitary IL 1beta and plasma IL 6 release following LPS challenge . ^^^ However , during times of stress , exogenous central IL 1ra administration only blocked sensitization of subsequent central IL 1beta responses , not CORT responses , suggesting other factors during the stress response can sensitize CORT responses . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Furthermore , constitutive IL 1beta secretion by AML blasts was detected only for a subset of patients , whereas relatively high levels of IL 1RA were observed for all patients ; coculture of AML blasts with HFL 1 fibroblasts and osteoblastic sarcoma cells increased IL 1beta levels for patients with constitutive IL 1beta secretion , whereas IL 1RA levels were slightly decreased but still generally higher than IL 1beta levels ( tested only for HFL 1 fibroblasts ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Enhanced IL 6 protein expression in Caco 2 cells induced by the initial treatment with IL 1beta or lipopolysaccharide could be abrogated by additional presupplementation of IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
It is known that IL 1 receptor antagonist ( IL 1RA ) binds to IL 1 receptors and inhibits the receptor binding of IL 1alpha and IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
On admission , serum levels for interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1Ra ) , IL 18 and interferon gamma ( IFNgamma ) as well as white blood cells ( WBC ) were significantly elevated in patients with fatal outcome compared to survivors with necrotizing fasciitis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We tested whether lipoxin A 4 ( LXA 4 ) and its stable synthetic analogue 16 phenoxy 17 18 , 19 , 20 tetranor lipoxin A 4 ( 16 phe LXA 4 ) modulated the ability of human blood monocytes ( MO ) to express mRNA and proteins for interleukin 1beta ( IL 1beta ) , IL 6 and IL 1 receptor antagonist ( IL 1Ra ) in vitro and compared their actions with lipopolysaccharide ( LPS ) and leukotriene B 4 ( LTB 4 ) . 16 phe LXA 4 , LPS and LTB 4 , but not LXA 4 , induced gene expression of IL 1beta in MO . ^^^ Prior exposure of MO to 16 phe LXA 4 , but not LXA 4 , reduced LTB 4 induced synthesis of IL 1beta with 66 % , IL 6 with 20 % and IL 1Ra with 29 % . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta and IL 1ra concentrations in vaginal lavage samples were measured by ELISA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
However , the IL 1beta inhibitors , IL 1 receptor antagonist ( IL 1RA ) and soluble IL 1 receptor type 2 ( sIL 1RII ) , regulate IL 1beta bioactivity . ^^^ HAECs produced IL 1beta , IL 1RA and sIL 1RII constitutively , but the inhibitor concentrations greatly exceeded that of IL 1beta ( by approximately 100 and approximately 550 fold , respectively ) . ^^^ In contrast , cGMP had no effect on IL 1beta but reduced IL 1RA and sIL 1RII release . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RESULTS : The gene expressions of IL 1R , IL 6R and gp 130 , but not IL 1beta , were observed . ^^^ The BeWo cells were cultured for 24 hr with IL 1beta ( 0 10 ng / mL ) , IL 1beta ( 10 ng / mL ) together with IL 1 receptor antagonist ( IL 1Ra ) or NF kappaB inhibitor , N tocyl l phenylalanine chloromethyl ketone ( TPCK ) . ^^^ The addition of IL 1Ra neutralized the effects of IL 1beta on IL 6 secretion . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The role of IL 1beta in the accelerated endothelial cell loss was determined by investigating the effect of human recombinant IL 1beta on their apoptosis in normal and high glucose conditions , and was confirmed using interleukin 1 receptor antagonist ( IL 1ra ) . ^^^ Supplementation of IL 1beta in 20 mM glucose medium further increased nitric oxide and NF kappaB , and accelerated apoptosis , and addition of IL 1ra significantly decreased glucose induced abnormalities and apoptosis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Here , we show that in mouse embryonic fibroblasts ( MEFs ) culture in vitro , expression of an inflammatory cytokine , interleukin 1beta ( IL 1beta ) and its antagonist , IL 1 receptor antagonist ( IL 1Ra ) are induced by senescence . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Inflammatory markers included interleukin ( IL ) 6 , soluble IL 6 receptor ( sIL 6r ) , tumor necrosis factor alpha ( TNF alpha ) , IL 1beta , IL 1 receptor antagonist ( IL 1ra ) , iron , ferritin , and C reactive protein ( CRP ) . ^^^ CPI was not associated with IL 1beta , IL 1ra , iron , ferritin , CRP , BMI , lipids , and smoking . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The levels of mouse IL 1beta and IL 12 in paws were significantly lower in the group treated with IL 1Ra than those in the control group . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Specifically , cells obtained from osteoarthritic ( OA ) ( n = 7 ) , rheumatoid arthritic ( RA ) ( n = 5 ) , and post traumatic ( PT ) ( n = 5 ) patients were stimulated in vitro with IL 1beta in the presence or absence of an IL 1 receptor antagonist ( IL 1ra ) ( anakinra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Western blot analysis revealed down regulation of expression of IL 1 receptor type 1 ( IL 1 R 1 ) in all cases of ECSC with low response to IL 1beta ( n = 8 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Here , we provide evidence that an impaired innate immune response , as measured by a low production capacity of pro and anti inflammatory cytokines upon ex vivo standardized danger signalling with bacterial LPS , is predictive for frailty in elderly people : participants who at age 85 year produced low levels of LPS induced IL 1beta , IL 6 , TNF alpha and IL 1Ra and IL 10 , were found to have a more than 2 fold elevated overall mortality risk , independent of chronic illnesses ( relative risk is 2 . 21 , 95 % confidence interval 1 . 27 3 . 82 , P = 0 . 005 ) , compared to peers with a higher production of any of the pro and / or anti inflammatory cytokines . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Plasma and colonic explant culture supernatants were assessed for IL 1alpha , IL 1beta , IL 1Ra , IL 1sRI and IL 1sRII . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
However , members of the interleukin 1 ( IL 1 ) family have clear therapeutic potential : the IL 1 agonists , IL 1 alpha and IL 1 beta , are induced by CNS injury , and central injection of IL 1 increases , whilst peripheral or central administration of the IL 1 antagonist , IL 1ra , reduces the extent of the damage by more than 50 % . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate Interleukin 1beta ( IL 1beta ) and IL 1 receptor antagonist ( IL 1ra ) concentrations in gingival crevicular fluid ( GCF ) of periodontally healthy teeth and to periodontitis teeth and to reveal their relationships to periodontal clinical indices . ^^^ The concentrations of IL 1beta and IL 1ra in GCF were quantified by ELISA method . ^^^ RESULTS : ( 1 ) The mean concentrations of IL 1beta and IL 1ra and the average value of 10 ( 4 ) IL 1beta / IL 1ra for periodontally healthy teeth were ( 61 . 891 + / 20 . 719 ) pg / ml , ( 739 . 410 + / 249 . 121 ) ng / ml and 0 . 857 + / 0 . 375 , respectively . ^^^ The mean concentration of IL 1beta ( 224 . 402 + / 87 . 416 ) pg / ml and the average value of 10 ( 4 ) IL 1beta / IL 1ra for periodontitis teeth 6 . 813 + / 0 . 375 were greater than those for healthy teeth , respectively ( P < 0 . 0001 ) , and in contrast , the mean concentration of IL 1ra for periodontitis teeth ( 366 . 722 + / 104 . 188 ) ng / ml was lower than that for healthy sites ( P < 0 . 0001 ) . ( 2 ) For all sites , a strong inverse relationship was found between IL 1beta and IL 1ra levels in GCF ( P < 0 . 01 ) . ^^^ Both of IL 1beta and 10 ( 4 ) IL 1beta / IL 1ra values had positive correlations with GI , PPD and CAL ( P < 0 . 01 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In non pregnant rats , E . coli LPS elicited statistically significant increases in plasma concentrations of IL 1beta , IL 6 , IL 1ra and TNFalpha as compared to that observed following administration of vehicle . ^^^ However in pregnant rats , E . coli LPS elicited statistically significant increases in antipyretic / cryogenic cytokines ( IL 1ra and TNFalpha ) but not in pyrogenic cytokines ( IL 1beta and IL 6 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the dermis adjacent to an ulcer , the expression of IL 1alpha , IL 1beta , IL 1Ra , EGF and PDGFa by EC was higher than the levels of expression in EC from the distant dermis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Liver tissue was analyzed for levels of IL 1beta , IL 1 receptor antagonist ( IL 1ra ) , tumor necrosis factor ( TNF ) alpha , and soluble TNF receptor 1 by ELISA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Transduction with IL 1Ra decreased the synovial expression of IL 1alpha and IL 1beta and matrix metalloproteinases , indicating a mechanism for prevention of matrix degradation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Incubation of HepG 2 cells with interleukin 1beta ( IL 1beta ) caused an increase in IL 1Ra levels , while interleukin 6 ( IL 6 ) had no effect on IL 1Ra synthesis . ^^^ Co stimulation of HepG 2 cells with HGF + IL 1beta resulted in a synergistic effect on IL 1Ra mRNA and protein expression . ^^^ A co stimulation with HGF and IL 1beta had a synergistic effect on IL 1Ra mRNA expression but only a partially additive effect on IL 1Ra protein synthesis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RESULTS : Circulating levels of vascular endothelial growth factor , tumor necrosis factor alpha , interleukin 1alpha ( IL 1alpha ) , and IL 1beta were not elevated significantly in patients with pancreatic carcinoma , but levels of IL 6 , IL 8 , IL 10 , and IL 1 receptor antagonist ( IL 1RA ) were elevated significantly ( P < 0 . 05 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1R type 1 ( IL 1RI ) binds IL 1alpha and IL 1beta , and subsequent recruitment of the membrane bound IL 1R accessory protein ( mIL 1RAcP ) facilitates signal transduction . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Increased steady state levels of messenger RNA ( mRNA ) for interferon gamma ( IFNgamma ) , TNFalpha , and interleukin 1beta ( IL 1beta ) , and lower levels of IL 1 receptor antagonist ( IL 1Ra ) mRNA were present in the joints of the EC SOD KO mice compared with the WT mice . ^^^ CONCLUSION : The absence of EC SOD leads to more severe CIA , which may be accompanied by enhanced production of the proinflammatory cytokines IFNgamma , TNFalpha , and IL 1beta , and decreased production of the antiinflammatory cytokine IL 1Ra in the joints . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
While the early ( day 1 ) IL 1 antagonist / agonist molar balance offered protection , by days 5 and 7 , a threshold for IL 1Ra in the presence of increasing IL 1beta expression favored pro inflammation in the BPD group . ^^^ CONCLUSIONS : We conclude that a strong and early expression of airway antagonist ( IL 1Ra ) proves ultimately to be sub optimal and non protective due to the robust expression of airway agonist ( IL 1beta ) seen by day 5 in premature infants who develop BPD . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Therefore the balance of IL 1beta and IL 1Ra may play a crucial role in the pathogenesis of diabetes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Cytokine specificity studies revealed that these compounds also inhibited the synthesis of the proinflammatory cytokines IL 1beta and IL 6 , while inhibition of IL 1ra and IL 8 synthesis was marginal and only occurred at high concentrations . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Effects of complete Freund ' s adjuvant on immunohistochemical distribution of IL 1beta and IL 1R 1 in neurons and glia cells of dorsal root ganglion . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1ra and indomethacin pretreatment strongly inhibited the hypernociception induced by IL 1beta , which was not altered by AbKC or guanethidine or by knocking out TNF R 1 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
An i . v . injection of IL 1beta ( 3 . 5 10 10 ( 15 ) 3 . 5 10 10 ( 9 ) g / kg ) inhibited the induction of LTP , which was diminished by the previous application of IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta gene polymorphisms at positions 511 and +3953 were evaluated by PCR RFLP and a penta allelic polymorphism of IL 1RA by PCR in healthy controls ( n = 103 ) and GC ( n =140 ; corpus 95 , antrum 45 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Basal and LPS induced production of cytokines IL 1beta , TNF alpha , and IL 1Ra was examined in macrophages exposed to nanoparticles . ^^^ However , Co nanoparticles reduced production of IL 1beta and IL 1Ra , but not TNF alpha , in LPS polarised M 1 macrophages . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RANTES , IL 8 , MIP 1alpha , MIP 1beta , IL 1beta , IL 10 , IL 12 p 35 , IL 18 , IFN gamma and IL 1Ra were the cytokine transcripts expressed in elevated levels from RNA of peripheral blood mononuclear cells of LGL leukemia patients . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In order to clarify the role of these polymorphisms in the complex pathogenesis of AD we examined genotype and haplotype frequencies of the two C to T SNPs at position 889 and 551 in the IL 1alpha and IL 1beta genes , respectively , and of the 86 bp VNTR intron 2 polymorphisms in the IL 1Ra gene . ^^^ In both groups , the analysis of the estimated haplotypes shows that AD patients and controls who carry the IL 1beta 511 C allele , were also more frequently carriers of the IL 1Ra 1 allele ( haplotypes C 1 ) . ^^^ Although ours and other published data on different samples of Caucasian and non Caucasian AD show a great heterogeneity in the frequencies of the IL 1alpha 889 , the IL 1beta 511 and the IL 1Ra VNTR gene polymorphisms , we confirm the role of the IL 1alpha 889 T / T genotype as a risk factor for sporadic AD , and show the presence of an allelic association between IL 1beta C and IL 1Ra 1 alleles in both the Italian and the USA groups , confirmed by the presence of significant levels of linkage disequilibrium between these two loci . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The production of interleukin 1 beta ( IL 1 beta ) and interleukin 1 receptor antagonist ( IL 1Ra ) by peripheral blood mononuclear cells ( PBMC ) was investigated without stimulation and with stimulation by a small amount of endotoxin ( ET ) contaminated beta 2 microglobulin ( beta 2M ) and lipopolysaccharide ( LPS ) before and after dialysis treatment in the last sessions during all periods . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IFN beta induces the production of secreted IL 1R antagonist ( sIL 1Ra ) without triggering synthesis of the agonist IL 1beta in human monocytes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : Vaginal specimens , obtained from 224 first trimester pregnant women , were assayed for interleukin 1beta ( IL 1beta ) and IL 1 receptor antagonist ( IL 1ra ) concentrations by ELISA . ^^^ M . hominis colonization was associated with elevated median vaginal IL 1beta concentrations in both black women ( p = 0 . 02 ) and Hispanic women ( p = 0 . 04 ) , and was unrelated to vaginal IL 1ra concentrations . ^^^ In marked contrast , U . urealyticum colonization was associated with elevations in vaginal IL 1ra levels , but not with IL 1beta concentrations , in black women ( p = 0 . 02 ) and Hispanic women ( p < 0 . 0001 ) and marginally in white women ( p = 0 . 06 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The innate immune responses were assessed by measuring production of proinflammatory ( TNF alpha , IL 1beta , IL 6 , and IL 12 ) and counter regulatory ( IL 1ra , IL 10 , and sTNFRII ) cytokines by peripheral blood mononuclear cells ( PBMCs ) with LPS . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Recombinant mouse IL 1beta induced strong activation of ERK1 / 2 , p 38 , JNK and NFkappa B , and significant release of IL 6 and PGE 2 , which was blocked by IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : Levels of messenger RNA for IL 1Ra and PPAR isotypes ( alpha , beta / delta , gamma ) were assessed by real time polymerase chain reaction in rat synovial fibroblasts exposed to 10 ng / ml of IL 1beta . ^^^ RESULTS : IL 1beta induced IL 1Ra production was increased by 10 microM rosiglitazone but was reduced dose dependently by 15 deoxy PGJ ( 2 ) . ^^^ Both agonists lowered IL 1beta secretion , but rosiglitazone alone reduced the imbalance of IL 1beta / IL 1Ra toward basal levels . ^^^ Enhancement of IL 1beta induced IL 1Ra production by rosiglitazone was not affected by PPARgamma overexpression or by its inhibition with dominant negative PPARgamma or GW 9662 . ^^^ Inhibition of NF kappaB was also ineffective against rosiglitazone but abolished the stimulating effect of IL 1beta on IL 1Ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The results indicated that IL 1beta could facilitate the onset of epilepsy induced by L glutamate through IL 1R , metabotropic glutamate receptors might work with IL 1R and the increased expression of AC might be involved in the process . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the mRNA studies , DAMB resulted in an early increase of inflammatory cytokines or chemokines IL 1beta , TNF alpha , MCP 1 , and MIP 1beta ( 2 to 6 h ) and in a late increase of anti inflammatory IL 1ra ( 22 h ) . ^^^ In protein measurement studies , DAMB and ABCD up regulated production of IL 1beta ( P < 0 . 05 ) , decreased the IL 1ra / IL 1beta ratio , and up regulated the production of MCP 1 and MIP 1beta . ^^^ In comparison , LAMB and ABLC down regulated or did not affect the production of these cytokines / chemokines compared to untreated MNCs ; furthermore , ABLC tended to increase the IL 1ra / IL 1beta ratio . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The expression of immunologic molecules ( prostaglandin E synthase , cyclooxygenase 2 , and IL 1beta ) in cultivated noncardiomyocytic cells and Th 1 cytokines ( IL 2 and IFN gamma ) in lymphocytes was significantly decreased by the serum containing IL 1RA Ig . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
BACKGROUND : As removal of pro inflammatory cytokines is limited in conventional diffusive or convective extracorporeal therapies , we studied in two polysulphone membranes with an industrial albumin sieving coefficient of 0 . 05 ( Type A ) and 0 . 13 ( Type B ) cytokine ( IL 6 , IL 8 , IL 1beta , IL 1ra , TNF alpha ) and plasma protein ( albumin , cystatin C , total proteins ) permeability profiles . ^^^ RESULTS : In haemofiltration mode both Type A and Type B haemodialysers at QB 150 ml / min exhibited similar median SC nearly up to 1 for IL 1beta and IL 1ra , at about 0 . 6 for IL 6 , 0 . 4 for IL 8 and 0 . 7 for TNF alpha , with clearance values ranging from 15 to 30 ml / min . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Expression of IL 1beta , IL 1ra , IL 6 , IL 10 and TNF alpha was investigated in host liver , lung and native heart in a rat model of chronic rejection 8 weeks after heterotopic cardiac transplantation in the absence of immunosuppression . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
CSF and serum concentrations of two proinflammatory mediators ( IL 1beta and TNF alpha , ) and three anti inflammatory mediators ( IL 1 receptor antagonist [ IL 1ra ] , soluble TNF receptor 1 [ sTNFr 1 ] , and IL 10 ) were measured and compared at 6 h after injury . ^^^ CSF concentrations of IL 1beta , IL 1ra , sTNFr 1 , and IL 10 were significantly higher ( P < 0 . 01 for all ) in patients with high intracranial pressure ( ICP ; n = 11 ) than in patients with low ICP ( n = 24 ) , and were also significantly higher ( P < 0 . 05 for all ) in patients with an unfavorable outcome ( n = 14 ) than in patients with a favorable outcome ( n = 21 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We report that administration of a neutral dose of IL 1beta abolished morphine analgesia in mice , whereas acute or chronic blockade of IL 1 signaling by various IL 1 blockers ( IL 1 receptor antagonist ( IL 1ra ) , alpha melanocyte stimulating hormone , or IL 1 tri peptide antagonist ) significantly prolonged and potentiated morphine analgesia . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVES : The aim of this clinical study was to intra individually compare Class 5 restorations of a calcium aluminate cement ( CAC ) , resin composite and enamel with respect to the adjacent levels of interleukin ( IL ) 1alpha , IL 1beta and IL 1 receptor antagonist ( IL 1ra ) in gingival crevicular fluid ( GCF ) . ^^^ The GCF concentrations of IL 1alpha , IL 1beta and IL 1ra were quantified with enzyme linked immunosorbent assays . ^^^ RESULTS : Neither the cross sectional study nor the experimental gingivitis study showed any significant differences in the levels of IL 1alpha , IL 1beta and IL 1ra between CAC , resin composite and enamel sites ( p > 0 . 05 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We analysed the distribution of single nucleotide polymorphisms ( SNPs ) located in the IL1A , IL1B , IL1R1 and IL1RN genes in alcoholic and non alcoholic Spanish subjects . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Utilizing a mouse cDNA array containing 514 chemokine and chemokine related genes , the loss of MCP 1 was observed to cause a significant upregulation of nine genes ( Decorin , Persephin , IL 1beta , MIP 2 , MSP , IL1ra , CCR 5 , CCR 3 , IL 11 ) and significant downregulation of two genes ( CCR 4 and CD3Z ) in acute wounds . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Association of IL 1Ra gene polymorphism , but no association of IL 1beta and IL 4 gene polymorphisms , with Kawasaki disease . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the current study we investigated the heritability of the cytokine ( IL 10 , IL 6 , IL 1beta , IL 1ra , TNF alpha ) production capacity upon ex vivo stimulation with amyloid beta in whole blood samples of 222 twins and 85 singleton siblings from 139 extended twin families . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1RI , IL 1RII , and IL 1Ra were all up regulated , whereas the IL 1beta converting enzyme , caspase 1 , and IRAK M were down regulated . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1ra / IL 1beta ratio in the ileum and large bowel was significantly lower than in controls before treatment . ^^^ The endoscopic and histologic healing of the mucosal inflammation was associated with a decline of the mucosal cytokines and an increase of the IL 1ra / IL 1beta ratio . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In contrast , human IL 1ra was only slightly effective in suppressing corneal inflammatory reactions . mRNA expression of murine IL 1ra and IL 1beta in the cauterised corneas was markedly suppressed after application of the conditioned medium . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Our results show that mononuclear cells from patients dialyzed with cellulosic membranes , exhibit : decrease telomere length , increase percentage of cells CD14dim / CD16bright and increase production of IL 1beta , IL1Ra and IL 6 cytokines . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : In a sibpair study of osteoarthritis ( OA ) patients , we investigated whether , upon stimulation with lipopolysaccharide ( LPS ) , variations in the innate ex vivo production of interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1Ra ) , IL 10 , and tumor necrosis factor alpha ( TNFalpha ) in whole blood assays contribute to the risk of OA . ^^^ Odds ratios ( ORs ) were used as measures of the relative risk of OA in relation to quartiles of IL 1beta , IL 1Ra , TNFalpha , and IL 10 production . ^^^ RESULTS : Subjects in the highest quartile of IL 1beta and IL 1Ra had an increased risk of OA ( OR 3 . 3 , 95 % CI 1 . 4 7 . 9 and OR 8 . 0 , 95 % CI 3 . 7 17 . 4 , respectively ) , while subjects in the lowest quartile of IL 10 had a 3 fold increased risk of OA ( OR 3 . 1 , 95 % CI 1 . 5 6 . 5 ) . ^^^ CONCLUSION : Subjects with a high innate ex vivo production of IL 1beta and IL 1Ra and low innate ex vivo production of IL 10 have an increased risk of OA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta and its natural receptor antagonist IL 1ra are involved in the inflammatory response to H . pylori infection . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
By mixing commercially available reagents and newly developed ones , a combination has been created that allows for the detection of 20 NHP chemokines and cytokines in a single sample , including G CSF , GM CSF , IFN gamma , IL 1beta , IL 1Ra , IL 2 , IL 4 , IL 5 , IL 6 , IL 8 , IL 10 , IL 12 ( p 40 ) , IL 17 , IL 18 , MCP 1 , MIP 1alpha , MIP 1beta , RANTES , TNF alpha , and TNF beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OHSCs obtained from rats were excitotoxically lesioned after 6 days in vitro by application of N methyl D aspartate ( NMDA ) and treated with IL 1beta ( 6 ng / mL ) or IL 1ra ( 40 , 100 or 500 ng / mL ) for up to 10 days . ^^^ Our findings indicate that : ( 1 ) IL 1beta directly affects the central nervous system and acts independently of infiltrating hematogenous cells ; ( 2 ) IL 1beta induces microglial activation but is not neurotoxic per se ; ( 3 ) IL 1beta enhances excitotoxic neuronal damage and microglial activation and ( 4 ) IL 1ra , even when applied for only 4 h , reduces neuronal cell death and the number of microglial cells after excitotoxic damage . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
On the expected day of implantation ( d 10 PO ) , IL 1beta ( 12 ng / d ) or IL 1 receptor antagonist ( IL 1Ra ; 12 ng / d ) was infused for an additional 5 d . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Upon admission and after complete clinical remission , basal plasma ACTH and serum cortisol levels as well as cytokine productions ( IL 1beta , IL 1 receptor antagonist ( IL 1RA ) ) upon mitogen stimulation ( PHA ) were measured in a whole blood assay . ^^^ Non melancholic patients produced significantly more IL 1beta and IL 1RA upon admission than controls or melancholic patients . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The synthetic peptide ( A3G756 ) induced cell migration and MMP 9 upregulation were inhibited by each application of a heparin and an IL 1 receptor antagonist ( IL 1RA ) , suggesting the involvement of syndecans and IL 1beta autocrine . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In turn , these effects were blocked with pretreatment of the selective IL 1 Type 1 receptor antagonist ( IL 1ra ) ( 10 ng ) , demonstrating the selectivity of the effects of IL 1beta on medial hypothalamic neurons upon PAG elicited defensive rage behavior . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Biological activity of the IL 1 system depends on the balance between two proinflammatory proteins ( IL 1alpha and IL 1beta ) and the related anti inflammatory protein , the IL 1 receptor antagonist ( IL 1Ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
This IgA mediated up regulation of IL 1RA is independent of the simultaneous up regulation of IL 1beta release , as shown by blocking the biological activity of IL 1beta with a neutralizing antibody . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the present work , IL 1beta ( experiment 1 , n = 13 ; experiment 2 , n = 25 ) and interleukin 1RA ( IL 1RA ; experiment 1 , n = 25 ) were injected intrafollicularly by using the transvaginal ultrasound guided injection method . ^^^ The results from experiment 1 confirm that an intrafollicular injection of 1 microgram IL 1beta induces ovulation in the mare whereas IL 1RA has no effect at the dose used in the present study . ^^^ Furthemore , we demonstrated , that in our experimental conditions , IL 1beta and IL 1RA induced a decrease in embryo development . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Immunohistochemistry was used to localize five members of the IL 1 family ( IL 1alpha , IL 1beta , IL 1Ra ( IL 1 receptor antagonist ) , IL 1RI ( IL 1 receptor , type 1 ) , and ICE ( IL 1beta converting enzyme ) ) in non degenerate and degenerate human IVDs . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Serum concentrations of IL 1alpha , IL 1beta , IL 1 receptor antagonist ( IL 1ra ) , as well as IL 6 and its soluble receptor ( IL 6sR ) were determined by the ELISA method . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1ra mediated suppression of clinical disease was associated with suppressed serum IFN gamma , TNF alpha , IL 1beta , IL 2 , IL 6 , C 3 , and anti AChR IgG 1 without influencing total serum IgG . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta promoter , IL 1beta exon 5 , IL 1Ra , IL 4 promoter , IL 4 intron 3 , and IL 10 gene polymorphisms were identified by polymerase chain reaction based restriction analysis . ^^^ There was no significant difference in the distribution of genotypes and allelic frequencies between RHD cases and controls for IL 1beta promoter , IL 1beta exon 5 , IL 1Ra , IL 4 promoter , IL 4 intron 3 , and IL 10 gene polymorphisms . ^^^ These findings suggest that the IL 1beta , IL 1Ra , IL 4 , or IL 10 gene polymorphisms are not suitable genetic markers for RHD in Taiwan Chinese . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The in vitro effect of the hydrophilic statin pravastatin and three hydrophobic statins atorvastatin , lovastatin and simvastatin on the production of IL 1beta , IL 1ra , IL 2 , IL 6 and IFN gamma by human peripheral blood mononuclear cells ( PBMC ) and their response to mitogens was examined . ^^^ Lovastatin and simvastatin increased the production of IL 1beta in a dose dependent manner and reduced secretion of IL 1ra at high concentration . ^^^ Atorvastatin did not affect IL 1beta , but suppressed IL 1ra , IL 2 and IFNgamma production . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
PCR was used to resolve the two IL 1beta polymorphisms and the IL 1Ra intron 2 polymorphism . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The present study was performed to analyze the responses of microglia to different forms of Abeta , with regard to release of the proinflammatory cytokines interleukin 1alpha ( IL 1alpha ) , IL 1beta , tumor necrosis factor alpha ( TNF alpha ) , IL 6 , and interferon gamma ( IFN gamma ) , as well as the IL 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
By means of immunohistochemistry and anti human antibodies , we showed that uterine tissues of L . vivipara ( seven oviparous and six viviparous animals ) expressed the two IL 1 isoforms , IL 1alpha and IL 1beta , and the type 1 IL 1 receptor ( IL 1R tI ) both at the pre ovulatory stage and during gestation , with no significant difference between oviparous and viviparous females . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1beta ( IL 1beta ) and its receptor antagonist ( IL 1Ra ) may play a pivotal role in the pathogenesis of wasting and inflammation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The aims were to investigate the effect of intravenous infusions of the tumor necrosis factor alpha ( TNF alpha ) antibody infliximab on symptoms and signs of temporomandibular joint ( TMJ ) involvement in relation to effects on synovial fluid and plasma proinflammatory TNF alpha , interleukin 1beta ( IL 1beta ) and interleukin 6 as well as antiinflam matory soluble TNF receptor 2 ( TNF sRII ) , interleukin 1 receptor antagonist ( IL 1ra ) , soluble IL 1 receptor 2 ( IL 1sRII ) and interleukin 10 ( IL 10 ) in patients with active rheumatoid arthritis ( RA ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
BACKGROUND : IL 1beta and IL 1RA levels are higher in the serum of cerebral malaria patients than in patients with mild malaria . ^^^ METHODS : To examine whether polymorphisms in IL1B and IL1RA influence the susceptibility to cerebral malaria , IL1B 31C > T , IL1B 3953C > T , and IL1RA variable number of tandem repeat ( VNTR ) were analysed in 312 Thai patients with malaria ( 109 cerebral malaria and 203 mild malaria patients ) . ^^^ RESULTS : In this population , IL1B 31C > T and IL1RA VNTR were detected , while IL1B 3953C > T ( i . e . , IL1B 3953T ) was not observed in the polymorphism screening for 32 patients . ^^^ Further analyses for IL1B 31C > T and IL1RA VNTR in 110 cerebral malaria and 206 mild malaria patients showed no significant association of these polymorphisms with cerebral malaria . ^^^ CONCLUSION : The present results suggest that IL1B 31C > T and IL1RA VNTR polymorphisms do not play a crucial role in susceptibility or resistance to cerebral malaria . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Fourteen cytokine genes were identified as candidates : gamma interferon ( IFNgamma ) ; interleukin ( IL ) 1 alpha ( IL 1alpha ) ; IL 1 beta ( IL 1beta ) ; IL 1 receptor ( IL 1R ) ; IL 1R antagonist ( IL 1RA ) ; IL 2 ; IL 4 ; IL 4 receptor alpha ( IL 4Ralpha ) ; IL 6 ; IL 10 ; IL 12B ; TGF beta 1 ( TGF beta 1 ) ; and TNF alpha ( TNF alpha ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
EC or fibroblasts exposed to both fibrinogen and IL 1beta , but not vitronectin and IL 1beta , demonstrated positive Western blotting for alphavbeta 3 after immunopurification with anti IL 1R , indicating specific association between alphavbeta 3 and IL 1R . ^^^ Dual immunofluorescence also revealed colocalization of alphavbeta 3 and IL 1R only when the cells were exposed to both fibrinogen and IL 1beta . ^^^ CONCLUSIONS : The enhanced NO production by ECs in the presence of fibrinogen bound IL 1beta requires the coordinated effects of colocalized alphavbeta 3 and IL 1R . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the secretions that were collected in the early phase and for 8 h after provocation , we measured histamine , and the cytokines interleukin ( IL ) 1beta , IL 8 , IL 4 , and the natural antagonist of IL 1beta , IL 1 receptor type 1 ( IL 1Ra ) using enzyme linked immunosorbent ( ELISA ) assays . ^^^ Its antagonist IL 1Ra was found in very high quantities ( 1000 fold higher than IL 1beta ) but demonstrated only marginal changes after provocation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1 receptor antagonist ( IL 1Ra ) is a protein that binds to IL 1 receptors and competitively inhibits the binding of IL 1alpha and IL 1beta . ^^^ Subjects with AS were genotyped for the following : IL 1alpha 889 single nucleotide polymorphism ( SNP ) ; IL 1beta +3953 SNP ; IL 1Ra ( 86 base pair variable number tandem repeat within intron 2 ) ; and NFKB 1 ( 94 insertion / deletion polymorphism ) . ^^^ RESULTS : In total , 205 subjects with AS and 200 controls from Seoul , Korea , and 68 subjects with AS and 164 controls from Toronto , Canada , were genotyped for the IL 1alpha and IL 1beta polymorphisms and 115 controls for the IL 1Ra and NF kappaB polymorphisms . ^^^ There were no differences of IL 1alpha , IL 1beta , IL 1Ra , and NF kappaB polymorphisms between AS patients and controls in these populations . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The purpose of this research was to test 3 hypotheses : ( 1 ) the velocity of tooth translation ( 5 ( t ) ) is related to applied stress and growth status , ( 2 ) a threshold of stress accounts for the lag phase , and ( 3 ) 5 ( t ) is correlated with the ratio ( AI ) of 2 cytokines ( IL 1beta , IL 1RA ) measured in gingival crevicular fluid ( GCF ) and stimulated whole blood ( SWB ) . ^^^ For growing subjects , SWB IL 1RA was correlated with 5 ( t ) ( R = 0 . 70 0 . 72 ) , and AI ( SWB ) and IL 1beta concentrations were correlated with AI ( GCF ) ( R = 0 . 73 0 . 78 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Adult rat Sertoli cells were incubated with the inflammatory mediators , lipopolysaccharide ( LPS ) , interleukin 1beta ( IL 1beta ) , IL 6 and the IL 1 receptor antagonist ( IL 1ra ) over 48 h in culture . ^^^ Blocking IL 1 activity in the cultures by addition of an excess of IL 1ra completely prevented the response of activin A to exogenous IL 1beta , and reduced the response to LPS by 50 % . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We compared the effects of fosfomycin , an antibiotic reported to possess immunomodulatory activities , and prednisolone on the production of interleukin 1 receptor antagonist ( IL 1ra ) and IL 1beta by bronchoalveolar lavage fluid ( BALF ) macrophages obtained from sarcoidosis patients . ^^^ The molar IL 1ra / IL 1beta ratio in the culture supernatants of BALF macrophages obtained from sarcoidosis patients , which was lower in sarcoidosis patients than in healthy nonsmokers , was significantly increased in the presence of fosfomycin , but decreased by prednisolone . ^^^ Further , the molar IL 1ra / IL 1beta ratios in the culture supernatants of peripheral blood mononuclear cells isolated from four of five patients after fosfomycin administration for 14 days were higher than the ratios measured before fosfomycin administration . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In both mixed species ( human fibroblasts rat ATII cells ) and same species cocultures ( rat fibroblasts and ATII cells ) , PGE 2 secretion was inhibited by the presence of IL 1 receptor antagonist ( IL 1Ra ) or selective neutralizing antibody directed against rat IL 1alpha ( but not IL 1beta ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Among them , 511 C / T in interleukin 1beta ( IL 1beta ) , tandem repeat in IL 1 receptor antagonist ( IL 1Ra ) , 308 G / A in tumour necrosis factor alpha ( TNF alpha ) were significantly associated with an increased risk of kidney failure . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The pro inflammatory cytokines , IL 1beta , TNF alpha and IL 6 , and the anti inflammatory cytokines , IL 10 and IL 1RA , were evaluated by ELISA . ^^^ There was no difference in the IL 1beta / IL 1RA ratio between the two groups , with and without LPS stimulation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The mechanism by which estradiol inhibits IL 1beta mediated responses by uterine epithelial cells appears to be the down modulation of the IL 1R type 1 , thereby reducing the uterine epithelial cell ' s ability to respond to IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Cytokine production seems to be initiated by signaling through TLR4 / type 1 IL 1R ( IL 1RI ) in response to their ligands , LPS and IL 1beta , playing vital roles in innate host defense against infections , inflammation , injury , and stress . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
VS also inhibited LPS dependent up regulation of IL 1beta and IL 6 mRNA in the brain , while increasing by 50 % the cerebral expression of transcripts of the specific antagonist of IL 1 receptors IL 1RA and IL 1R2 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Culture of the human islets at 11 and 28 mmol / l glucose induced a four to fivefold increase in medium insulin as compared with 5 . 6 mmol / l glucose , but neither IL 1beta nor IL 1 receptor antagonist ( IL 1ra ) expression changed . ^^^ IL 1beta and IL 1ra protein release to the medium was also unchanged . ^^^ The findings on mRNA levels were essentially the same as in the in vitro experiments , namely the in vivo diabetic state did not induce IL 1beta , Fas , or MCP 1 expression in human islets , and also did not modify IL 1ra expression . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : We have studied 511 C / T and +3953 T / C polymorphisms of the IL1B gene , a HinfI polymorphism in the 5 ' UTR of the IL1R1 gene , and a variable number of tandem repeats ( VNTR ) in the intron 2 of the IL1RN gene , in 165 patients diagnosed as suffering from PDB and in 122 healthy controls . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta versus IL 1ra ; TNF versus IL 10 ) have a profound influence on the outcome of the response . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURE ( S ) : The differences of IL 1 system mRNA and the ratio of IL 1beta to IL 1 receptor antagonist ( IL 1ra ) in both fallopian tubes with ectopic pregnancies and normal controls were analyzed . ^^^ As QC PCR demonstrated , IL 1beta mRNA expression was decreased , and IL 1ra and IL 1 receptor type 1 were increased in fallopian tubes with ectopic pregnancies in comparison with normal control tubes . ^^^ There was a lower ratio of IL 1beta to IL 1ra at mRNA in fallopian tubes with ectopic pregnancies . ^^^ CONCLUSION ( S ) : These results suggest that an inappropriate ratio of IL 1beta to IL 1ra and a higher expression of its receptor in fallopian tubes may possibly be implicated to the implantation of an ectopic pregnancy in the oviduct . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Recent evidence shows that endogenous IL 1beta has proconvulsant actions mediated by interleukin 1 receptor type 1 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We measured serum IL 6 , IL 1beta , TNF alpha , IL 4 and IL 1 receptor antagonist ( IL 1Ra ) concentrations before and after patients listened to the story . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
These lavages were analyzed for interleukin ( IL ) 1alpha , IL 1beta , IL 1ra , and tumor necrosis factor ( TNF ) alpha . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Enzyme linked immunosorbent assays were used to determine the levels of interleukin ( IL ) 1alpha , IL 1beta , IL 1 receptor antagonist ( IL 1Ra ) , IL 6 , IL 10 , tumor necrosis factor ( TNF ) alpha , and lymphotoxin ( LT ) alpha in peripheral blood ( plasma ) and unstimulated and stimulated whole blood cell cultures from the same blood collection . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Both EPO and CEPO equivalently decreased the EAE associated production of TNF alpha , IL 1beta and IL 1Ra in the spinal cord , and IFN gamma by peripheral lymphocytes , indicating that their action involves targeting neuroinflammation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : White blood cell counts and cytokine levels ( IL 1beta , IL 1Ra , IL 6 , IL 8 , IL 18 , and IFN gamma ) were measured in patients presenting to the emergency department with severe soft tissue infections and high suspicion of NF . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The range of evaluated parameters comprised the indices of immune competence of T cells in microcultures of mononuclear cells isolated from the blood ( response to mitogens PHA and Con A , saturation of IL 2 receptors , T cell suppressive activity SAT index ) , indices of immunogenic activity of monocytes ( LM index correlated with the ratio of concentrations of IL 1 beta / IL 1ra , concentrations of IL 1beta , IL 1ra , IL 4 and IL 6 in the culture supernatants ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The production of IL 1alpha , IL 1beta , IL 1 receptor antagonist ( IL 1ra ) , IL 6 , and soluble IL 6 receptor ( sIL 6r ) by lipopolysaccharide stimulated whole blood cells was measured by ELISA in 110 subjects . ^^^ IL 1alphaC ( 889 ) T polymorphism , IL 1beta C ( 511 ) T polymorphism , 86 base pair variable number tandem repeat polymorphism in the IL 1ra gene , and IL 6 C ( 634 ) G polymorphism were analyzed . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
These myeloid suppressor cells ( MSC ) are present in many patients with cancer and inhibit the activation of CD4+ and CD8+ T lymphocytes . 4T1 / IL 1beta induced MSC do not express the IL 1R , suggesting that the cytokine does not directly activate MSC . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The IL 1alpha C ( 889 ) T polymorphism , and IL 1beta C ( 511 ) T polymorphism were examined by restriction fragment length polymorphism , and 86 bp variable number tandem repeat polymorphism in the IL 1ra gene was analyzed by the polymerase chain reaction and electrophoresis in 202 postmenopausal Korean women . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To explore the role of the IL 1 / IL 1Ra system in autoimmune disease , we analyzed myelin oligodendrocyte glycoprotein ( MOG ) induced experimental autoimmune encephalomyelitis ( EAE ) in mice bearing targeted disruptions of the IL 1alpha , IL 1beta , IL 1alpha and IL 1beta ( IL 1 ) or IL 1Ra genes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Three hours to 10 days following the injection , mice were killed and testis and spleen were homogenized and examined for interleukin ( IL ) 1alpha , IL 1beta , and IL 1 receptor antagonist ( IL 1ra ) levels by enzyme linked immunosorbent assay and polymerase chain reaction . ^^^ RESULTS : Subcutaneous injection of turpentine induced mice systemic inflammation , as indicated by significant increase in serum IL 1beta levels , and IL 1alpha , IL 1beta and IL 1ra in spleen homogenates . ^^^ The levels of IL 1alpha , IL 1beta and IL 1ra were significantly induced in testicular homogenates of adult mice following subcutaneous injection of turpentine . ^^^ However , significant induction of testicular IL 1beta was detected only after 3 10 days of turpentine injection , and for testicular IL 1ra levels was detected after 3 hr to 6 days of turpentine injection , and after 10 days the levels were similar to the control . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We tested the hypothesis that components of the immune response , particularly the proinflammatory cytokine interleukin 1beta ( IL 1beta ) and its naturally occurring antagonist interleukin 1 receptor antagonist ( IL 1ra ) may play a role in the genesis of FC . ^^^ Brains were harvested at and 2 h after onset of FCs to measure brain levels of IL 1beta and IL 1ra . ^^^ Separate groups of animals were given intracerebroventricular ( ICV ) injections of IL 1beta , or IL 1ra in an attempt to establish a causal relation between the IL 1beta / IL 1ra system and FCs . ^^^ When animals were treated with IL 1beta ICV , a dose dependant increase was noted in the proportion of animals that experienced FCs , whereas increasing doses of IL 1ra , given to separate groups of animals , were anticonvulsant . ^^^ This may occur by overproduction of IL 1beta , or by alteration in the IL 1beta / IL 1ra ratio in the brain after an immune challenge . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Moreover , an impaired neutrophil influx is found in an in vivo model of crystal induced peritonitis in inflammasome deficient mice or mice deficient in the IL 1beta receptor ( IL 1R ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We , therefore , studied the effects of infusion of the alpha MSH agonist , [ Nle ( 4 ) , d Phe ( 7 ) ] alpha MSH ( NDP MSH ) ; the alpha MSH antagonist , SHU 9119 ; and the selective MC 3 R agonist , D Trp 8 gamma MSH , compared with saline , on proinflammatory cytokine ( TNF alpha , IL 1beta , and IL 6 ) , antiinflammatory cytokine [ IL 10 and IL 1 receptor antagonist ( IL 1ra ) ] , and pituitary adrenal responses to endotoxin in ovariectomized monkeys . ^^^ The area under the response curve ( AUC ) decreased by 61 % for TNF alpha ( P = 0 . 02 ) , 47 % for IL 1beta ( P = 0 . 02 ) , and 41 % for IL 6 ( P = 0 . 04 ) ; there was no effect on IL 1ra or IL 10 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Ethnicity greatly influences the interleukin 1 gene cluster ( IL 1b promoter , exon 5 and IL 1Ra ) polymorphisms : a pilot study of a north Indian population . ^^^ Polymorphisms in interleukin 1 beta ( IL 1beta ) and IL 1 receptor antagonist ( IL 1Ra ) genes , respectively encoding a potent inflammatory agent and an antagonist , which combines with IL 1 receptors competitively , have been associated with a number of diseases like systemic lupus erythematosus , rheumatoid arthritis , sepsis , kidney diseases , and cancer . ^^^ In this study , we therefore evaluated the distribution of interleukin 1 gene cluster ( IL 1beta promoter region , exon 5 and IL 1Ra ) gene polymorphisms in 206 healthy north Indian subjects , using PCR based restriction analysis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Cytokine ratio of IL 1ra / IL 1beta ( low ratio indicative of inflammation ) and production of those cytokines as a percentage of medium control were assayed in the culture supernatant . ^^^ Incubation of non inflamed non IBD control tissue did not increase the IL 1ra / IL 1beta ratio in any dilution compared to medium control ( 69 . 3+ / 47 . 0 , 54 . 1+ / 30 . 6 , 79 . 4+ / 34 . 0 vs control 76 . 1+ / 37 . 3 ) . ^^^ CONCLUSION : IBD tissues , after incubation with elemental diet modified in its fatty acid composition with fish oil , show an increase in IL 1ra / IL 1beta cytokine ratio . ^^^ This effect of omega 3 fatty acid modulation is significantly more marked in UC compared with CD and is accompanied by both a reduction of IL 1beta and increase of IL 1ra . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Pretreatment of the ic IL 1ra transfected cells with antisense oligonucleotide directed against the mRNA of icIL 1ra restored MMP 1 expression induced by stimulation with IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Such activation and association of receptors were blocked by a PDGFR beta neutralizing antibody ( AF 385 ) , an IL 1R1 antagonist ( IL 1ra ) , as well as a specific inhibitor of PDGFR beta phosphorylation ( AG 1295 ) ; these agents also eliminated the PDGF BB / IL 1beta induced signaling and phenotypic modulation . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
AIM : To study the serum concentration of IL 1beta , IL 1 receptor antagonist ( IL 1Ra ) and IL 18 in Galphai 2 deficient mice at the age of 6 ( healthy ) , 12 ( pre colitic ) and 24 wk ( colitic ) and in healthy control mice . ^^^ METHODS : At the time of killing , serum samples were collected and IL 1beta , IL 1Ra and IL 18 levels were measured using enzyme linked immunosorbent assays . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We used a newly developed multiplexed mutagenic separated PCR assay to analyze 6 polymorphisms within the IL 1 cluster : IL1A ( 889 ) C / T , IL1A ( +4845 ) G / T , IL1B ( 511 ) C / T , IL1B ( 31 ) C / T , IL1B ( +3954 ) , and IL1RA ( +2018 ) C / T . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
DESIGN : Genotyping of the 2 IL 1beta gene ( IL1B ) polymorphisms ( promoter and exon ) and the IL 1Ra gene ( IL1RN ) polymorphism ( intron 2 ) was performed using polymerase chain reaction and restriction length fragment polymorphism analyses . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
As a consequence , glucan phosphate shifted the TSST 1 induced IL 1beta / IL 1RA ratio towards an anti inflammatory phenotype . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In humans with sepsis , for IL 1beta , IL 1Ra , IL 6 , IL 8 , and TNF alpha , the adsorbing rates in vivo before and after the use of the Lixelle column tended to decrease with time . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We investigated whether or not uremic serum has an influence on IL 1beta and IL 1Ra production by normal peripheral blood mononuclear cells ( PBMC ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We generated mice deficient in IL 6 and IL 1Ra ( IL 6 ( / ) IL 1Ra ( / ) ) and IL 6 , IL 1alpha , and IL 1beta ( IL 6 ( / ) IL 1 ( / ) ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Moreover , brief applications of IL 1beta to voltage clamped oocytes yielded a delayed potentiation of the GABA elicited chloride currents ( 1 ( GABA ) ) ; this effect was suppressed by IL 1ra , the natural IL 1 receptor ( IL 1RI ) antagonist . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Lymph node cells derived from mBSA sensitized IL 1beta / , IL 1alpha / beta / and IL 1R type 1 ( IL 1RI ) / mice , but not from IL 1alpha / mice , exhibited reduced proliferative responses against mBSA , while these from IL 1Ra / mice demonstrated augmented responses . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta and IL 1Ra soluble contents were measured by ELISA . ^^^ CloF also maximized IL 1beta induced endogenous production of soluble IL 1Ra ( sIL 1Ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We investigated 30 patients with idiopathic pulmonary fibrosis ( IPF ) and 103 healthy volunteers for the cytokines polymorphisms of the IL 1alpha , IL 1beta , IL 1R , IL 1RA , IL 2 , IL 4 , IL 6 , IL 10 , IL 12 , tumor necrosis factor alpha , interferon gamma , transforming growth factor beta , IL 1beta , IL 2 , IL 4 , and IL 4RA genes . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Although enhanced expression of IL 1 family proteins , including IL 1alpha , IL 1beta , and IL 1 receptor antagonist ( IL 1ra ) during wound healing has been observed , the pathophysiological roles of these factors , particularly IL 1ra , still remain elusive . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1beta further increased the production of IL 23 , which induced IL 17 production and OX 40 expression in splenic CD 4 ( + ) T cells of IL 1Ra ( / ) mice . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We evaluated single nucleotide polymorphism ( SNPs ) in interleukin 1 gene cluster , IL 1beta ( promoter region 511 and exon 5 +3954 ) and IL 1Ra ( 86 bp VNTR ) in 136 renal transplant recipients and 150 normal healthy controls by polymerase chain restriction based ( PCR RFLP ) analysis . ^^^ LD value for IL 1beta ( promoter region ) and IL 1Ra and IL 1beta promoter and exon 5 gene in the control group indicated strong association among the variants ( D ' =0 . 37 , p < 0 . 0001 and D ' =0 . 29 , p=0 . 002 ) . ^^^ Our study demonstrate that genetically determined low production of IL 1Ra may be a risk factor for RE and DGF and that IL 1beta / IL 1Ra haplotype influences the impact of allograft outcome . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Subjects had serum drawn for immunoglobulins E and G 4 ( IgE , IgG 4 ) to 3 antigens , Der p 1 , Der f 1 , and Fel d 1 , and for interleukins IL 1beta , IL 2 , IL 4 , IL 5 , IL 10 , IL 12 , and IL 13 , and IL 1 receptor antagonist ( IL 1RA ) . ^^^ Analysis demonstrated significant increases in IgG 4 levels to all antigens , significant decreases in serum levels of IL 1beta and IL 5 , and significant increases in levels of IL 1RA . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RESULTS : A significant difference was found in the frequency distribution of the IL 1Ra gene polymorphism in patients with bladder cancer compared with the normal control group ( P < 0 . 001 ) , but no difference was found in the frequencies of the IL 1beta promoter region and exon 5 genotypes between patients with bladder cancer and controls ( P = 0 . 112 and P = 0 . 953 , respectively ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Tumor necrosis factor a ( TNF a ) , interleukin 6 ( IL 6 ) , interleukin 1 beta ( IL 1beta ) and interleukin 1 receptor antagonist ( IL 1ra ) were used to assess the inflammatory status ; and circulating immunoglobulins ( IgM , IgA , IgG and IgG subclasses ) and specific IgG titer to tetanus were used to assess humoral immunity . ^^^ No significant differences were found in TNF a , IL 1beta and IL 1ra between the groups . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVES : The aim of this study was to investigate the influence of plasma and synovial fluid tumour necrosis factor alpha ( TNFalpha ) , interleukin 1beta ( IL 1beta ) , IL 6 , soluble TNF receptor 2 ( TNF sRII ) , IL 1 receptor antagonist ( IL 1ra ) , soluble IL 1 receptor 2 ( IL 1sRII ) and IL 10 on the effect of the TNFalpha antibody infliximab on temporomandibular joint ( TMJ ) pain in patients with active rheumatoid arthritis ( RA ) . ^^^ RESULTS : The effect of infliximab on TMJ pain was influenced by pretreatment plasma levels of IL 1beta , IL 1ra , and IL 10 as well as pretreatment levels of TMJ synovial fluid IL 1sRII . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
These individuals were genotyped for IL 1 beta ( promoter 511 and exon 5 +3953 ) genes and a variable number of tandem repeats ( VNTR ) in the IL 1 receptor antagonist gene ( IL 1Ra ) . ^^^ There was significant difference in genotype frequencies between ESRD patients and control group for IL 1beta ( promoter region and exon 5 ) and IL 1Ra gene polymorphism ( p < 0 . 001 , 0 . 006 and < 0 . 001 , respectively ) . ^^^ Genetic linkage between the IL 1beta promoter region and exon 5 and between the IL 1beta promoter and IL 1Ra of IL 1 gene demonstrated a strong association among the variants in controls ( D ' = 0 . 42 , p < 0 . 001 , and D ' = 0 . 39 , p=0 . 001 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Association of polymorphisms in CTLA 4 , IL 1ra and IL 1beta genes with multiple sclerosis in Serbian population . ^^^ We have investigated separate as well as combined influence of IL 1beta TaqI , IL 1ra VNTR and CTLA 4 + 49 A / G polymorphisms on susceptibility , clinical course and progression of MS in 162 Serbian patients . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
A biochemical evaluation for a battery of cytokines was undertaken ( IL 1beta , IL 1ra , IL 2 , IL 2R , IL 4 , IL 5 , IL 6 , IL 7 , IL 8 , IL 10 , IL 12p40 , IL 13 , IL 15 , IL 17 , TNF alpha , IFN alpha , IFN gamma , GM CSF , MIP 1alpha , MIP 1beta , IP 10 , MIG , Eotaxin , RANTES , and MCP 1 , and neuropeptides ) using high resolution multiplex bead immunoassays and enzyme linked immunosorbent assay ( ELISA ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To examine the mRNA expression of IL 1beta and its receptor antagonist IL 1RA in the skin of horses , biopsy specimens of horses affected and non affected by CHS prior and following intradermal challenge with a commercial C . nubeculosus extract were examined . ^^^ No significant difference was detected in non challenged cutaneous IL 1beta mRNA and IL 1RA mRNA levels between CHS affected and non affected horses . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In all patients , the cytokines IL 1alpha , IL 1beta , IL 1ra , TNFalpha , IFNgamma , IL 2 , and TGFbeta were investigated using specific antibodies . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHOD OF STUDY : Cervicovaginal lavage samples from 206 women at 18 22 weeks of gestation were tested for NO , interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1ra ) , tumor necrosis factor alpha and the inducible 70 kDa heat shock protein ( hsp 70 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
SUBJECTS : Male mice 6 8 wks of age , in which genes for IL 1alpha and IL 1beta ( IL 1alpha / beta deficient ) and IL 1 receptor antagonist ( IL 1RA deficient ) are deleted by homologous recombination , and wild type controls on a Balb / c background . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In the 11 premenopausal onset cases , lower serum dehydroepiandrosterone sulfate levels were observed as was an imbalance in serum IL 1beta to IL 1ra levels ; the latter was not observed in the 43 controls ( CNs ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 beta ( IL 1beta ) and its endogenous IL 1 receptor antagonist ( IL 1Ra ) play an important role in inflammatory response and in pain modulation . ^^^ It has recently been shown that polymorphism of the IL 1beta and IL 1Ra genes may account for variation in the production of these cytokines . ^^^ The present study examined the hypothesis that polymorphism of IL 1beta and IL 1Ra genes is involved in pain sensitivity and morphine consumption in the immediate postoperative period . ^^^ The genotype of IL 1Ra was determined using PCR amplification of the variable number of tandem repeats ( VNTR ) of 86 base pair ( bp ) in intron 2 , while for IL 1beta the cytosine to thymine transition at codon 511 of the promoter was determined by PCR . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The following polymorphisms were analyzed : IL 1alpha 889 C / T , IL 1beta +3953 C / T , and IL 1RA ( 86 bp ) n . ^^^ No significant differences in genotype or in allelic distribution of the Il 1alpha , IL 1beta , and IL 1RA polymorphisms were found . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We immunocytochemically investigated the brain expression and cellular distribution pattern of IL 1beta , IL 1 receptor ( IL 1R ) types 1 and 2 and IL 1R antagonist ( IL 1Ra ) in FCD and GNT specimens , and we correlate these parameters with the clinical history of epilepsy in patients with medically intractable seizures . ^^^ In normal control cortex , and in perilesional regions with histologically normal cortex , IL 1beta , IL 1Rs and IL 1Ra expression was undetectable . ^^^ These findings show a high expression of IL 1beta and its functional receptor ( IL 1RI ) in FCD and GNT specimens together with a relative paucity of mechanisms ( IL 1RII and IL 1Ra ) apt to inactivate IL 1beta actions . ^^^ Moreover , the number of IL 1beta and IL 1RI positive neurons was positively correlated with the frequency of seizures , whereas the number of IL 1Ra positive neurons and astroglial cells was negatively correlated with the duration of epilepsy prior to surgery . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The changes after surgery included an increased macrophageal digesting capacity with switching to oxygen independent mechanisms , as well as increased levels of TNF alpha , IL 1ra , and IL 1ra : IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Also , to assess the influence of IL 1 B and IL1RN gene polymorphism on IL 1beta / IL 1Ra plasma levels and response to therapy . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RESULTS : At entry , the mucosal concentrations of interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1ra ) , IL 6 , IL 8 , and tumor necrosis factor alpha ( TNF alpha ) were significantly higher compared with the control group , whereas IL 1ra / IL 1beta ratio was significantly lower . ^^^ In patients with clinical remission but not in those without remission , the mucosal tissue concentrations of IL 1beta , IL 1ra , IL 6 , IL 8 , and TNF alpha significantly decreased , whereas the IL 1ra / IL 1beta ratio significantly increased . ^^^ Furthermore , endoscopic remission of mucosal inflammation was observed in 14 ( 50 % ) patients , which was associated with a decline in mucosal IL 1beta , IL 1ra , IL 6 , IL 8 , and TNF alpha and an increase in IL 1ra / IL 1beta ratio . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Plasma levels of IL 1beta , TNF alpha , IL 8 , IFN gamma , IL 1ra and TNF BP 1 , as well as stress hormones ( cortisol and prolactin ) were measured . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The MCM induced production of SDF 1 was prevented by IL 1beta receptor antagonist ( IL 1Ra ) and IL 1beta siRNA treatment of human MDM . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
IL 1Ra binds competitively to the same membrane receptor as interleukin 1beta ( IL 1beta ) and thereby acts as an antagonist to the pro inflammatory actions of IL 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Plasma ghrelin and insulin and blood glucose were measured after intraperitoneal injection of LPS , intravenous injection of IL 1beta and urocortin 1 , and in response to LPS under conditions of blockade of IL 1 or CRF receptors by subcutaneous injection of IL 1 receptor antagonist ( IL 1Ra ) or astressin B , respectively , and prostaglandin ( PG ) synthesis by intraperitoneal indomethacin . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Low IL 1beta also induced the IL 1 receptor antagonist ( IL 1Ra ) , suppression of which by RNA interference abrogated the beneficial effects of low IL 1beta . ^^^ These findings indicate that low IL 1beta levels positively influence beta cell function and turnover through the Fas FLIP pathway and that IL 1Ra production prevents harmful effects of high IL 1beta concentrations . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 regulates cytokine gene expression in human mesangial cells through the interleukin 1 receptor type 1 . ^^^ An additional finding of this study was that human mesangial cells constitutively express the 80 kd interleukin 1 receptor type 1 gene . ^^^ When human mesangial cells were exposed to interleukin 1 , interleukin 1 receptor expression was not modified . ^^^ Similarly , other stimuli like tumor necrosis factor , transforming growth factor beta , or interleukin 6 did not modulate interleukin 1 receptor expression . ^^^ Recombinant interleukin 1 receptor antagonist blocked the interleukin 1 mRNA as well as interleukin 6 and interleukin 8 mRNA accumulation induced by interleukin 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The neuroprotective effect of hrIL 1 beta was reversed by coapplication of an IL 1 receptor antagonist ( IL 1ra , 50 micrograms / ml ) . ^^^ In contrast , exposure of cultures to high concentrations hrIL 1 beta alone ( 100 micrograms / ml , 1 . 3 10 10 ( 6 ) U / ml ) for periods up to 72 hr resulted in neurotoxicity , which was reversed by IL 1ra ( 1 mg / ml ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
A detectable level of TGF beta 1 was found 8 h after stimulation and a plateau was reached at 72 h with a maximal increase of 5 fold and was inhibited by IL 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 4 ( IL 4 ) has previously been found to downregulate interleukin 1 ( IL 1 ) production , but to upregulate the production of IL 1 receptor antagonist ( IL 1ra ) in human monocytes stimulated with lipopolysaccharide ( LPS ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Here we have demonstrated that two marker genes ( lacZ and neo ) and cDNA coding for a potentially therapeutic protein ( human interleukin 1 receptor antagonist protein ; IRAP or IL 1ra ) can be delivered , by ex vivo techniques , to the synovial lining of joints ; intraarticular expression of IRAP inhibited intraarticular responses to interleukin 1 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The rhIL 1 beta induced hyperalgesia was completely abolished by pretreatment with an IL 1 receptor antagonist ( IL 1ra ) or Na salicylate . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Intraperitoneal endotoxin ( 1 microgram / rat ) induced inhibition of gastric acid secretion was not altered by pretreatment with the interleukin 1 receptor antagonist , IL 1RA , indomethacin , naloxone , or capsaicin . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
We addressed the role of interleukin 1 ( IL 1 ) as a co stimulatory signal in monocyte dependent anti CD 3 mediated T cell proliferation by using specific and anti IL 1 subtype antibodies and IL 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
A maximum 86 fold increase for IL 1ra , a 7 8 fold increase for TNF R 55 BP , and a 2 3 fold increase for TNF R 75 BP were seen 2 4 h , 1 h , and 4 h , respectively , after rhIL 1 beta infusion . ^^^ Our data show that early after rhIL 1 beta infusion the induction of IL 1ra secretion , as well as TNF binding protein release , is observed . . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
RhIL 1 beta ( 20 pg / kg ) induced hyperalgesia was completely blocked by the simultaneous injection of IL 1 receptor antagonist ( IL 1ra , 20 ng / kg ) , Na salicylate ( 200 ng / kg ) or alpha melanocyte stimulating hormone alpha MSH , 20 ng / kg ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In hepatocytes , the NO formation induced by IL l beta was blocked by both the NO synthase ( NOS ) inhibitor NG monomethyl L arginine ( L NMMA ) and by IL 1 receptor antagonist ( IL 1ra ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In monocyte suspensions , pretreated with human recombinant IL 1 receptor antagonist ( IL 1ra ) 500 ng / ml for 10 min and then treated with LPS or hrIL 1 beta 10 micrograms / ml , the release of TxB 2 was partially inhibited . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Evaluation of interleukin 1 receptor antagonist ( IL 1RA ) and tumor necrosis factor binding protein ( TNF BP ) in a rodent abscess model of host resistance . ^^^ To determine if the cytokine antagonists interleukin 1 receptor antagonist ( IL 1ra ) and tumor necrosis factor binding protein ( TNF bp ) alter host resistance mechanisms they were evaluated in a rodent abscess model . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
These end points were examined : ( 1 ) after administration of the locally active steroid budesonide ; ( 2 ) in congenitally athymic rats ; and ( 3 ) in rats treated with the interleukin 1 receptor antagonist ( IL 1ra ) to interleukin 1 beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The basal and LPS stimulated levels of interleukin 1 beta and tumour necrosis factor alpha ( TNF alpha ) and the basal level of interleukin 1 receptor antagonist ( IL 1RA ) were identical for the 3 groups . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 beta ( IL 1 ) and tumour necrosis factor alpha ( TNF ) are important for the beta cell lysis in insulin dependent diabetes mellitus ( IDDM ) , while IL 1 receptor antagonist ( IL 1ra ) is considered protective by blocking the effects of IL 1 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Concentrations and ex vivo production of interleukin 1 beta ( IL 1 ) , tumour necrosis alpha ( TNF ) , interleukin 6 ( IL 6 ) , interleukin 1 receptor antagonist ( IL 1RA ) and TNF soluble receptors ( sTNF receptors , P 55 and P 75 ) were measured in bronchoalveolar lavage ( BAL ) fluid and blood in 23 HIV seropositive ( HIV+ ) patients with Pneumocystis carinii pneumonia ( PCP ) and compared with values found in healthy HIV seronegative ( HIV ) controls and asymptomatic HIV+ subjects . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : As part of two sequential multisite , prospective , randomized , double blind , placebo controlled clinical trials , 37 patients with severe sepsis received interleukin 1 receptor antagonist ( IL 1ra ) 100 mg bolus followed by 2 mg / kg per hour intravenously for 72 hours ( n = 20 ) or placebo ( n = 17 ) . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Release of interleukin 1 receptor antagonist ( IL 1Ra ) and prostaglandin E 2 into the medium was monitored by immunoassay . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Also interleukin 1 receptor antagonist ( IL 1ra ) and a polyclonal anti NGF antiserum significantly reduced thymulin induced hyperalgesia . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Simultaneously , IFN beta increased the production of IL 1 receptor antagonist ( IL 1Ra ) by 37 % and did not modulate the release of TNF soluble receptors ( TNF sRs ) p 55 and p 75 . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVES : To clone equine interleukin 1 receptor antagonist ( IL 1ra ) and determine its full length cDNA sequence . ^^^ Similarity between sequence for equine IL 1ra and sequences for equine interleukin 1 alpha and equine interleukin 1 beta were 22 . 6 and 24 . 6 % , respectively . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Furthermore , blockade of IL 1 receptors by the specific interleukin 1 receptor antagonist ( IL 1ra ) resulted in a reversible impairment of long term potentiation maintenance without affecting its induction . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The antiinflammatory cytokine response during urosepsis was determined by measurement of concentrations of soluble tumor necrosis factor receptor ( sTNFR ) types 1 and 2 , interleukin 1 receptor antagonist ( IL 1ra ) , soluble IL 1 receptor type 2 ( sIL 1RII ) , and interleukin 10 in sera and urine of 30 patients with culture proven urinary tract infections before and 4 , 24 , 48 , and 72 h after initiation of antibiotic therapy and in 20 healthy individuals . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The aim of this study was to investigate the expression of secretory and intracellular isoforms of interleukin 1 receptor antagonist ( IL 1Ra ) in human primary IECs and carcinoma derived cell lines . ^^^ Transcription of intracellular IL 1Ra 1 mRNA was significantly up regulated with inflammation and in vitro by phorbol myristate acetate and interleukin 1beta . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 receptor antagonist ( IL 1RA ) reversed the inhibition induced by the macrophage supernatant in a concentration dependent manner . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
In coculture with keratinocytes , fibroblasts exhibit an enhanced expression of keratinocyte growth factor and the interleukin 1 receptor ( type 1 ) , which further increase with culture time . ^^^ The functional significance of this double paracrine pathway , i . e . , induction of keratinocyte growth factor expression in fibroblasts by keratinocytes via release of interleukin 1 , was confirmed by interfering with both signaling elements : ( 1 ) interleukin 1 neutralizing antibodies and interleukin 1 receptor antagonist significantly inhibited keratinocyte growth factor release , keratinocyte proliferation , and tissue formation comparable to the effect produced by keratinocyte growth factor blocking antibodies ; ( 2 ) addition of keratinocyte growth factor to cocultures with inactivated interleukin 1 pathway completely reverted growth inhibition ; ( 3 ) in organotypic cocultures with subthreshold fibroblast numbers both interleukin 1 and keratinocyte growth factor restored the impaired epidermal morphogenesis . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The levels of the cytokines , tumour necrosis factor alpha , interleukin 1beta , interleukin 6 , interferon gamma and interleukin 1 receptor antagonist ( IL 1ra ) by peripheral blood mononuclear cells ( PBMC ) were determined simultaneously by the whole blood assay and the PBMC assay in 20 patients with gastric cancer and in 10 healthy volunteers . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate the effect of aminoguanidine ( AG ) on de novo interleukin 1beta ( IL1beta ) , nitric oxide ( NO ) , and interleukin 1 receptor antagonist ( IL1ra ) production by osteoarthritic human synovial tissue and articular cartilage cultures . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Gene transfer of bovine pancreas trypsin inhibitor ( BPMI ) or interleukin 10 ( IL 10 ) reduced the invasion of RA SF , while transduction of interleukin 1 receptor antagonist ( IL 1Ra ) was chondroprotective . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 receptor immunoreactivity in sympathetic vascular and non vascular neurons in guinea pig coeliac ganglion . ^^^ Immunoreactivity ( IR ) for the interleukin 1 receptor type 1 ( IL1RI ) was examined in sympathetic neurons in guinea pig coeliac ganglion using multiple labelling immunofluorescence . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Homozygous deletion of IL 1 receptor 1 ( IL1R1 ) , TNF receptor 1 or 2 ( TNFR 1 or TNFR 2 ) , or IFNgamma receptor 1 ( IFNgammaR 1 ) alone had no effect but combined deletion of TNFR 1 and TNFR 2 caused a striking absence of alphaX beta 2 integrin / IBA1 double labeled , phagocytic microglial nodules in the axotomized facial motor nucleus 14 days after nerve cut . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The effects of both substances were blocked by the endogenous interleukin 1 beta receptor antagonist ( Il 1ra , 250 microg , I . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
OBJECTIVE : Recent studies on cerebral ischemia in the rat have demonstrated that administration of interleukin 1 receptor antagonist ( IL 1ra ) markedly reduces the volumes of infarcts which are associated with N methyl D aspartate ( NMDA ) mediated neurotoxicity . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
I . c . pre treatment with the interleukin 1 receptor antagonist , IL 1ra , failed to restore acid secretory responses in these rats . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Interleukin 1 receptor antagonist ( IL1Ra ) was frequently detected in the synovial membrane of normal subjects ( mean ( SD ) integrated optical density ( IOD ) =3809 . 6 ( 3893 . 9 ) ) , but both tumour necrosis factor alpha ( TNFalpha ) and interleukin 1beta ( IL1beta ) were rarely detected . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
A toxicologically relevant functional assay for alpha amanitin uptake was developed by measuring its ability to block cytokine induced synthesis of interleukin 1 receptor antagonist ( IL 1Ra ) mRNA . ^^^ Treatment with interleukin 1beta ( 10 ng / ml ) and interleukin 6 ( 100 ng / ml ) increased IL 1Ra mRNA abundance 8 . 6 fold and 15 . 6 fold in HepG 2 cells and Ntcp transfected cells , respectively . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
B7 . 2 on activated and phagocytic microglia in the facial axotomy model : regulation by interleukin 1 receptor type 1 , tumor necrosis factor receptors 1 and 2 and endotoxin . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
Although interleukin 1beta was marginally increased , blockade of both interleukin 1 isoforms or interleukin 1 receptor type 1 with neutralizing antisera failed to reduce alveolar bone loss in interleukin 10 ( / ) mice , indicating the operation of an interleukin 1 independent mechanism . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
METHODS : An experimental cold challenge protocol was developed to study the acute inflammatory mechanisms occurring after a general cold exposure in FCAS patients and to investigate the effects of pretreatment with an antagonist of interleukin 1 receptor ( IL 1Ra ) . ^^^ INTERPRETATION : The ability of IL 1Ra to prevent the clinical features and haematological and biochemical changes in patients with FCAS indicates a central role for interleukin 1beta in this disorder . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
The N terminal 24 amino acids ( Ser 5 Ala28 ) of human interleukin 1beta ( hIL 1beta ) and interleukin 1 receptor antagonist ( IL 1ra ) were used as secretion enhancer for synthesizing recombinant human granulocyte colony stimulating factor ( rhG CSF ) from S . cerevisiae . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
To investigate possible roles of proinflammatory cytokines and acquired immunity in the gastric hyperplasia of K 19 C2mE mice , we introduced knockout mutations for tumor necrosis factor alpha ( TNF alpha ; Tnf ) , interleukin 1 receptor alpha chain ( Il1r1 ) , and Rag 2 genes , respectively . ^^^ In contrast , tumorigenesis remained unaffected in either compound mutants of K 19 C2mE containing Il1r1 or Rag 2 mutation , indicating that neither interleukin 1beta signaling nor T cell / B cell response was required for the development of hyperplastic tumors . ^^^
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01584 and P14778	Pubmed	SVM Score :0.0
NA