| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Rabbit chondrocytes in culture constitutively produced the zymogen of MMP 2 ( proMMP 2 ) and its production was not altered by treatment with IL 1 beta or PKC agonists alone or in combination . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Prostaglandins , IL 1 beta , MMP 2 , and MMP 3 could act synergetically as promotors in the rapid destruction of the hip joint . . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The present study was undertaken to assess the effect of interleukin 1 beta ( IL 1 beta ) , platelet derived growth factor ( PDGF ) , and transforming growth factor beta 1 ( TGF beta ) on the expression of collagenase ( MMP 1 ) and TIMP 1 mRNA in periodontal derived fibroblasts using reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ IL 1 beta induced a 5 to 9 fold increase in MMP 1 mRNA . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| While exposure of most cell types to interleukin 1 beta ( IL 1 beta ) , tumour necrosis factor alpha ( TNF alpha ) or phorbol ester has little or even an inhibitory effect on 72 kDa type 4 collagenase secretion , these factors significantly increased the synthesis of this enzyme by rat MC . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Among these mediators , only IL 1 beta was found to enhance the amounts of HSF membrane bound HSFE 1 and Gelatinase A . . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| We here provide evidence that UVA induced IL 1 alpha and IL 1 beta play a central role in the induction of the synthesis both of IL 6 and collagenase / MMP 1 . ^^^ This early peak of IL 1 bioactivity appears to be responsible for the induction of IL 6 synthesis and together with IL 6 lead to an increase of the steady state mRNA level of collagenase / MMP 1 as deduced from studies using IL 1 alpha and IL 1 beta antisense oligonucleotides or neutralizing antibodies against IL 1 alpha and IL 1 beta . ^^^ From these data we suggest a UV induced cytokine network consisting of IL 1 alpha , IL 1 beta and IL 6 , which via interrelated autocrine loops induce collagenase / MMP 1 and thus may contribute to the loss of interstitial collagen in cutaneous photoaging . . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Here , we report that IL 1beta , but not IL 1alpha , is degraded by MMP 1 ( interstitial collagenase ) , MMP 2 ( gelatinase A ) , MMP 3 ( stromelysin 1 ) , and MMP 9 ( gelatinase B ) . ^^^ The primary cleavage site of IL 1beta by MMP 2 was identified at the Glu 25 Leu26 bond . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Mesenchymal cells isolated from the mucosa of human fetal small intestine produced increased amounts of interstitial collagenase , gelatinase A , and stromelysin 1 when stimulated with IL 1beta or TNF alpha . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta ( IL 1 beta ) is a potent cytokine that stimulates interstitial collagenase 1 ( matrix metalloproteinase 1 ; MMP 1 ) . ^^^ Northern analysis showed that the time course of collagenase induction was distinct in the two cells : although both cells expressed low levels of MMP 1 constitutively , addition of IL 1 beta increased MMP 1 mRNA in HFFs by 1 h and levels remained high over a 24 h period . ^^^ In contrast , MMP 1 levels in IL 1 beta treated BC 8701 cells did not increase until 4 h , peaked by 12 h and then declined . ^^^ To analyze the transcriptional response , we cloned and sequenced more than 4 , 300 bp of the human MMP 1 promoter , and from this promoter clone , we prepared a series of 5 ' deletion constructs linked to the luciferase reporter and transiently transfected these constructs into both cell types to measure both basal and IL 1 beta induced transcription . ^^^ Finally , we found that IL 1 beta stabilized MMP 1 mRNA in normal fibroblasts , but not in BC 8701 breast cancer cells . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Whereas MMP 1 is positively regulated by IL 1beta , tumor necrosis factor alpha , and Oncostatin M , MMP 2 is not modulated by any of these cytokines . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta ( IL 1 beta ) was shown to produce a 7 fold elevation in collagenase ( MMP 1 ) mRNA levels , consistent with primary PDL cells . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In contrast , transcripts for PAI 1 were elevated during pregnancy , while those for collagenase ( MMP 1 ) , urokinase , TIMP 3 , IL 1beta , TNF , COX 2 and iNOS were not statistically altered . mRNA transcript levels rebounded by 7 days post partum for most genes studied , indicating that the changes were rapidly reversible . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| METHODS : Interleukin 1 alpha ( IL 1 alpha ) , interleukin 1 beta ( IL 1 beta ) , interleukin 6 ( IL 6 ) , stromelysin 1 ( MMP 3 ) , interstitial collagenase ( MMP 1 ) , tissue inhibitor for metalloproteinases 1 ( TIMP 1 ) , phospholipase activity A 2 ( PLA 2 ) , hyaluronan ( HA ) , aggrecan fragments ( AGN ) and antigenic keratan sulfate ( KS ) were quantified in knee joint lavage fluid from 96 patients with CM ; KS and HA also was measured in serum . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The present study examines the effect of transforming growth factor beta 1 ( TGF beta 1 ) and interleukin 1beta ( IL 1beta ) on the regulation of gelatinase A , gelatinase B , tissue inhibitor of metalloproteinase 1 ( TIMP 1 ) and TIMP 2 in human glomerular epithelial cells ( GEC ) . ^^^ In contrast , the addition of IL 1beta to GEC resulted in the stimulation of secretion of gelatinase B but not gelatinase A . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| TNF alpha , granulocyte macrophage CSF ( GM CSF ) , or IL 1 beta when added individually enhanced the endogenous levels of 92 kDa gelatinase ( MMP 9 ) and TIMP 1 but failed to induce interstitial collagenase ( MMP 1 ) . ^^^ However , GM CSF , when added with either TNF alpha or IL 1 beta , induced MMP 1 and synergistically enhanced MMP 9 and TIMP 1 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| We describe here that stromelysin 1 ( MMP 3 ) , as well as the gelatinases A ( MMP 2 ) and B ( MMP 9 ) , processes recombinant human IL 1 beta precursor ( pIL 1 beta ) into biologically active forms . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The production of MMP 1 by fibroblasts and synoviocytes upon cellular contact with stimulated T cells was higher than that induced by an optimum concentration of IL 1beta , whereas the production of PGE 2 was equivalent or slightly lower . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Here , we describe the influence of heparin ( s ) on the interleukin 1 beta ( IL 1beta ) induced expression of collagenase ( matrix metalloproteinase 1 , MMP 1 ) , stromelysin 1 ( matrix metalloproteinase 3 , MMP 3 ) and tissue inhibitor of matrix metalloproteinase 1 ( TIMP 1 ) in human gingival fibroblasts ( HGF ) . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| On direct cell cell contact , stimulated T lymphocytes potently trigger the production of pro inflammatory factors such as interleukin 1beta ( IL 1beta ) and matrix metalloproteinases ( MMP 1 and MMP 9 ) , as well as anti inflammatory factors such as IL 1 receptor antagonist ( IL 1Ra ) and the tissue inhibitor of metalloproteinases ( TIMP 1 ) in peripheral blood monocytes and the monocytic cell line THP 1 . ^^^ Upon contact with T lymphocytes stimulated in the presence of 10 5 M LF , the molar ratio of IL 1Ra / IL 1beta and TIMP 1 / MMP 1 produced by THP 1 cells was enhanced 3 . 6 and 1 . 9 fold , respectively , whereas it was enhanced only 1 . 3 and 1 . 4 fold upon contact with T lymphocytes stimulated in the presence of 10 4 M DEX . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| A beta , but not interleukin 1beta ( IL 1beta ) or lipopolysaccharide ( LPS ) , stimulated an active form of MMP 2 in human U 87 glioblastoma cells , as well as increased the expression of the well known activator of MMP 2 , membrane type ( MT ) MMP . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| This down regulatory effect of CD 40 engagement on MMP 1 and MMP 3 production by gingival fibroblasts was also present when MMP production was up regulated by IL 1beta and TNF alpha or down regulated by IFN gamma . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In addition , the production and activation status of equine MMP 2 and 9 by equine articular cells and tissues in response to increasing IL 1beta concentrations was assessed . ^^^ A mild increase in active and zymogen MMP 2 levels occurred with IL 1beta treatment . ^^^ Equine synovial membrane explants demonstrated a dose dependent increase in active and zymogen MMP 2 and MMP 9 levels following IL 1beta treatment . ^^^ Monolayer chondrocyte cell cultures demonstrated a dose dependent mild increase in active and zymogen MMP 2 following IL 1beta treatment . ^^^ Explant cartilage cultures demonstrated a dose dependent mild increase in zymogen MMP 2 alone following IL 1beta treatment . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In the present study we sought to investigate whether there is any correlation between the expression of gelatinases ( MMP 2 and MMP 9 ) , TIMP 1 , and the expression of cytokines and growth factors such as interleukin 1beta ( IL 1beta ) , IL 6 , IL 10 , tumor necrosis factor alpha ( TNF alpha ) , transforming growth factor beta ( TGFbeta ) , and basic fibroblast growth factor ( bFGF ) in human NHL . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Subsequent Northern blotting revealed expression of pro inflammatory cytokines , including interleukin ( IL ) 1alpha and IL 1beta , was induced by rEDA prior to MMP 1 expression . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To determine IL 1 beta , TNF alpha , IL 6 , IL 4 , IL 10 , MMP 1 , MMP 3 and MMP 13 expression by freshly isolated peripheral blood ( PBMC ) and synovial fluid mononuclear cells ( SFMC ) in early , never treated ( ENT RA ) and non acute , treated rheumatoid arthritis ( NAT RA ) patients . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| From this study we conclude the following : ( a ) similar histopathologic changes occur in both knee and ankle cartilages ; ( b ) MMP 1 , 2 , 13 , and 14 are constitutively expressed in adult human cartilage ; and ( c ) only up regulation of mRNA expression of MMP 3 and MMP 8 could be detected with naturally occurring cartilage damage and IL 1beta induction . . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Considering these results , it is suggested that 1 ) MIF plays an important role in the tissue destruction of rheumatoid joints via induction of the proteinases , and 2 ) MIF up regulates MMP 1 and MMP 3 via tyrosine kinase , protein kinase C , and AP 1 dependent pathways , bypassing IL 1beta signal transduction . . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| We have recently shown that BMSCs produce MMP 1 , the major metalloproteinase involved in the initiation of bone resorption , production up regulated by IL 1beta . ^^^ Here , we demonstrate that zoledronate significantly inhibits MMP 1 production by BMSCs stimulated with IL 1beta more efficiently than pamidronate . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| At nanomolar concentrations , LXA 4 inhibited these IL 1 beta responses with reduction of IL 6 and IL 8 synthesis , by 45 + / 7 % and 75 + / 11 % , respectively , and prevented IL 1 beta induced MMP 3 synthesis without significantly affecting MMP 1 levels . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Immunohistologic analysis was performed using monoclonal antibodies specific for the following phenotypic markers and mediators of joint inflammation and destruction : CD 3 , CD 38 , CD 68 , CD 55 , tumor necrosis factor alpha ( TNFalpha ) , interleukin 1beta ( IL 1beta ) , IL 6 , MMP 1 , and TIMP 1 . ^^^ RESULTS : A statistically significant reduction in the mean immunohistologic scores for CD3+ T cells and the expression of MMP 1 and TIMP 1 at 1 month , CD38+ plasma cells and the expression of IL 6 at 3 months , and the expression of IL 1beta at both 1 and 3 months was observed in synovial tissue after IFNbeta treatment . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The amounts of IL 1beta , IL 12 and IL 1ra detected in our uveitis patients correlated with levels of MMP 2 ( p < 0 . 07 , p < 0 . 0004 , p < 0 . 03 ) and MMP 9 ( p < 0 . 003 , p < 0 . 0001 , p < 0 . 002 ) , and IL 12 ( p < 0 . 004 , p < 0 . 0001 ) . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To determine the effects of sulfasalazine ( SASP ) and its metabolites sulfapyridine ( SP ) and 5 amino salicylic acid ( 5ASA ) on steady state mRNA levels of inflammatory cytokines [ interleukin 1beta ( IL 1beta ) , tumor necrosis factor alpha ( TNF alpha ) ] , matrix metalloproteinases [ collagenase ( MMP 1 ) , stromelysin ( MMP 3 ) , gelatinase 72 kDa ( MMP 2 ) ] , tissue inhibitors of metalloproteinase ( TIMP 1 and TIMP 2 ) , and the TNF alpha receptor in rheumatoid synovial fibroblasts . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| We also observed that MMP 1 was toxic to human neurons grown in dissociated cultures and that increased amounts of MMP 1 were released by astrocytes following their stimulation with IL 1beta . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The addition of interleukin 1beta ( IL 1beta ) increased MMP 1 levels in the culture media of ECs . ^^^ Amlodipine , but not nifedipine , significantly decreased MMP 1 levels in IL 1beta stimulated ECs . ^^^ Our findings revealed that amlodipine , but not nifedipine , inhibits IL 1beta induced MMP 1 expression in human ECs . . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| IL 1beta and TNF alpha each increased total matrix metalloproteinase ( MMP ) activity as measured by in gel zymography , causing specific increases in the bands corresponding to MMP 13 , MMP 2 , and MMP 9 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Addition of IL 4 , IL 13 and IL 10 to synoviocyte cultures reduced the spontaneous production of MMP 1 and induced TIMP 1 production by synoviocytes stimulated with IL 17 or / and IL 1beta . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : IL 1beta and TNF alpha dramatically increased the mRNA and protein expression of MMP 1 and MMP 3 in cultured PBF when compared to normal HJF and to their nonstimulated counterparts cultured in a serum free medium . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : MMP 2 is not secreted by rheumatoid osteoblasts as a proenzyme ; however , IL 1 beta stimulation induced the secretion of MMP 2 as an active form from rheumatoid osteoblasts . ^^^ This MMP 2 activating activity was detected significantly in IL 1 beta stimulated rheumatoid osteoblasts . ^^^ In support of this result , IL 1 beta stimulation induced the expression of membrane type matrix metalloproteinase ( MT MMP ) , a newly identified MMP 2 specific activator , in rheumatoid osteoblasts . ^^^ CONCLUSION : These results suggest that IL 1 beta induces MMP 2 activation in part by up regulating MT MMP expression and represents a new mechanism for cytokine mediated articular destruction in RA . . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The levels of interleukin 1beta ( IL 1beta ) , IL 6 , TNF alpha , intercellular adhesion molecule 1 ( ICAM 1 ) and MMP 1 were determined by means of enzyme linked immunosorbent assay ( ELISA ) and Northern blotting analysis . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Frozen synovial tissue sections were stained for macrophages ( CD 68 ) , T cells ( CD 3 ) , adhesion molecules ( intercellular adhesion molecule 1 [ ICAM 1 ] , vascular cell adhesion molecule 1 [ VCAM 1 ] ) , cytokines ( tumor necrosis factor alpha , interleukin 1beta [ IL 1beta ] ) , matrix metalloproteinase 1 ( MMP 1 ) , and tissue inhibitor of metalloproteinases 1 ( TIMP 1 ) . ^^^ In the subset of patients fulfilling the 20 % response criteria of the American College of Rheumatology , a more pronounced reduction in the expression of ICAM 1 , VCAM 1 , IL 1beta , and MMP 1 was found compared with the nonresponders . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| IL 1beta markedly and TNF alpha to lesser extent increased mRNA and protein expression of MMP 1 and MMP 3 in conjunctivochalasis fibroblasts from 2 subjects when compared with normal conjunctival fibroblasts from 2 subjects and with their nonstimulated counterparts . ^^^ Expression of MMP 2 , TIMP 1 , and TIMP 2 mRNA and protein was not influenced by IL 1beta or TNF alpha , and no difference was found in the gelatinolytic activity of MMP 2 between both cell types . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The concentrations of TNF alpha , IL 1beta , IL 4 , IL 6 , IL 10 , IFN gamma , MMP 1 , and MMP 3 appeared to be similar in the two groups , although the small number of samples available precluded us from determining that there was no significant difference . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| PCR Southern blot analysis showed that the high magnitude cyclic tensile load increased the mRNA level of MMP 1 , MMP 3 , MMP 9 , IL 1beta , TNF alpha and TIMP 1 in the cultured chondrocytes , while the mRNA level of MMP 2 and TIMP 2 was unchanged . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The MMP 2 activities of the three cell lines were significantly increased in the presence of IL 1beta and IL 6 , but no modulation of MMP 2 activities was observed in the presence of OSM , LIF and GH . ^^^ An upmodulation of pro MMP 2 secretion by SaOS 2 and hOb was observed for all soluble factors used , whereas an upmodulation of pro MMP 2 secretion by MG 63 was observed only in the presence of IL 1beta , IL 6 and IGF 1 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In response to the proinflammatory cytokine IL 1beta , the protein and mRNA for MMP 9 was induced , while secretion of MMP 2 was unaltered . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Matrix metalloproteinase assay indicated that IL 1beta , TNF alpha and PDGF induced intestitial collagenase ( MMP 1 ) production . ^^^ MMP assay also indicated that IL 1beta and TNF alpha had inhibitory effects on MMP 2 , 9 ( gelatinaseA , B ) production . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| While IL 1beta up regulated MMP 1 , 3 , 9 and 13 , it had no significant effect on expression of either TIMP . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| TNF alpha and IL 1 beta induced increases in the concentrations of MMP 1 , MMP 3 , and MMP 9 , but not in MMP 2 or tissue inhibitor of matrix metalloproteinase ( TIMP ) 1 or 2 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The results showed that Smad 3 and Smad 4 , but not Smad 1 or Smad 2 , mimicked the inhibitory effect of TGF beta and abrogated interleukin 1beta ( IL 1beta ) induced stimulation of MMP 1 promoter activity and NFkappaB specific gene transcription in dermal fibroblasts . ^^^ Overexpression of the transcriptional co activator p 300 , but not its histone acetyltransferase ( HAT ) deficient mutant , was able to relieve repression of MMP 1 gene expression , suggesting that Smad dependent inhibition may be due to increased competition between Smad proteins and IL 1beta signaling pathways for limiting amounts of cellular p 300 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Combination of PGF2alpha and IL 1beta induced a synergistic increase of MMP 1 production in HGF . ^^^ Furthermore , fluprostenol , a specific FP receptor agonist , increased MMP 1 production and induced a synergistic enhancement of IL 1beta induced MMP 1 production in HGF , similar to PGF2alpha . ^^^ Northern blot analysis revealed that PGF2alpha enhanced MMP 1 mRNA expression in HGF and that PGF2alpha increased MMP 1 mRNA levels induced by IL 1beta . ^^^ In conclusion , we suggest that PGF2alpha increases MMP 1 production in HGF and synergistically enhances MMP 1 production in IL 1beta stimulated HGF . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined the effects of IL 1beta , one of the inflammatory cytokines , on the expression of MT 1 MMP and the activation of pro MMP 2 using rheumatoid synovial cells . ^^^ An active form of MMP 2 was demonstrated in the culture media conditioned by IL 1beta stimulated synovial cells . ^^^ KE 298 blocked this IL 1beta induced pro MMP 2 activation and MT 1 MMP expression , but did not affect IL 1beta induced tissue inhibitor of metalloproteinase 2 ( TIMP 2 ) secretion from rheumatoid synovial cells . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In contrast , 1alpha , 25 ( OH ) ( 2 ) D ( 3 ) had a slight stimulatory effect on basal production of MMPs 1 and 3 by monolayer cultures of HACs , but stimulation of MMP 1 by IL 1beta was not affected by the simultaneous addition of 1alpha , 25 ( OH ) ( 2 ) D ( 3 ) whilst MMP 3 production was enhanced ( Table 1 ) . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : In the absence of IL 1beta , a slight decrease in the secretion of MMP 2 was observed with lower doses of ASU , ASF , and SSF . ^^^ As anticipated , IL 1beta induced a marked release of MMP 2 , MMP 3 , and TIMP 1 , but no variation for TIMP 2 was seen . ^^^ ASU , ASF , and SSF reversed the IL 1beta effect on gingival fibroblasts for MMP 2 and MMP 3 , particularly with doses varying from 0 . 1 to 2 . 5 microgram / ml and for TIMP 1 , particularly with doses varying from 2 . 5 to 10 microgram / ml . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| This study investigated the regulation of MMP 2 and MMP 9 in human corneal epithelial cells by growth factors and pro inflammatory cytokines ( IL 1beta and TNF alpha ) they are exposed to , and by doxycycline , a medication used to treat ocular surface disease . ^^^ Between the two gelatinases , MMP 2 and MMP 9 , detected by zymography , the 92 kDa MMP 9 in the conditioned medium was markedly up regulated by the pro inflammatory cytokines , IL 1beta and TNF alpha . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The application of fluid flow led to an increased expression of the collagenase 1 ( MMP 1 ) , stromelysin 1 ( MMP 3 ) , cyclooxygenase 2 ( COX 2 ) and interleukin 1beta ( IL 1beta ) genes . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Human synovial fibroblasts were cultured with IL 1beta in the absence or presence of PPARgamma activators , and the expression and production of MMP 1 were evaluated by Northern blot and ELISA , respectively . ^^^ PPARgamma activators ( 15d PGJ ( 2 ) and BRL 49653 ) inhibited IL 1beta induced MMP 1 synthesis in a dose dependent manner . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In combination with TNF or IL 1beta , hTWEAK further stimulated the secretion of prostaglandin E 2 , MMP 1 , IL 6 and IL 8 up to fourfold , and IP 10 and RANTES up to 70 fold compared to TNF or IL 1beta alone . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The effect of endogenous eicosanoids on basal and induced levels of IL 1beta , TNF alpha , and MMP 1 synthesis was examined by incubating explants in the presence of NS 398 and Bay 10 1005 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| IL 1beta and TNF alpha both induced a dose and time dependent increase in IL 8 , MCP 1 and MMP 1 secretion , and weakly stimulated MMP 2 secretion . ^^^ The inhibition of NF kappaB activation markedly blocked both IL 1beta and TNF alpha induced IL 8 and MCP 1 mRNA expression , but did not affect MMP 1 mRNA expression . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| IL 1beta induced the expressions of MMP 1 , MMP 13 , and GLS mRNAs and proteins in a dose dependent manner . ^^^ These findings suggest that chondrocytes may intensify cartilage destruction and inflammation in RA by the induction of MMP 1 , MMP 13 , and GLS by IL 1beta and that the p 38 MAPK pathway plays an important role in these inductions . . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| This is evidenced by the fact that TENS at low magnitude : ( 1 ) inhibits recombinant human ( rh ) IL 1beta dependent induction of cyclooxygenase 2 ( COX 2 ) mRNA expression and production of prostaglandin estradiol ( PGE 2 ) ; ( 2 ) inhibits rhIL 1beta dependent induction matrix metalloproteinase 1 ( MMP 1 ) and MMP 3 synthesis by suppressing their mRNA expression ; ( 3 ) abrogates rhIL 1beta induced suppression of tissue inhibitor of metalloprotease 2 ( TIMP 2 ) expression ; and ( 4 ) reverses IL 1beta dependent suppression of osteocalcin and alkaline phosphatase synthesis . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Using zymography , we investigated MMP 2 production by human endometrial cells treated with estradiol 17beta + progesterone ( E ( 2 ) +P ) and by various key cytokines in endometrial physiology ( IL 1beta , LIF , TGF beta , and TNF alpha ) . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Enhanced protein expression of IL 1beta , IL 8 and MMP 1 was also observed in RA FLS . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| PROCEDURE : Stationary monolayers of first passage chondrocytes were exposed to graduated concentrations of PGE 2 with or without a subsaturating dose ( 50 pg / ml ) of recombinant equine IL 1beta ( reIL 1beta ) to induce expression of MMP 1 , MMP 3 , MMP 13 , and TIMP 1 , followed by RNA isolation and northern blotting . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| TGF beta ( 2 ) , IL 1beta , and TNF alpha enhanced secretion of MMP 1 , 2 , and 3 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Incubation of both stromal and epithelial cells with IL 6 , LIF and IL 11 had no effect on MMP 2 , 7 , 9 , transforming growth factor ( TGF ) beta or IL 1beta production or cell growth . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to investigate the production and regulation of MMP 1 and MMP 3 in human gingival fibroblasts challenged with the cytokines interleukin lbeta ( IL 1beta ) , tumor necrosis factor alpha ( TNFalpha ) or epidermal growth factor ( EGF ) . ^^^ The results showed that gingival fibroblasts constitutively produce MMP 1 and MMP 3 , and that the cytokines IL 1beta , TNFalpha and EGF increase both MMP 1 and MMP 3 production in gingival fibroblasts . ^^^ In addition , MMP 1 and MMP 3 production , induced by IL 1beta , TNFalpha or EGF , was strongly reduced by the presence of the glucocorticoid dexamethasone . ^^^ Our findings demonstrate that the cytokines IL 1beta , TNFalpha and EGF , respectively , enhance both MMP 1 and MMP 3 production in human gingival fibroblasts , and that the signal pathways COX 2 , MAP kinases and tyrosine kinases are partly involved in the production of MMPs . . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| IL 1beta , TNF alpha , IL 6 , IL 8 , MMP 1 , TIMP 1 , Cox 1 , VCAM 1 , ICAM 1 and Fas / APO95 expression was evaluated by immunohistochemistry . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| MMP 1 and MMP 13 were expressed much higher in vitro than in vivo and were up regulated by IL 1beta . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| However , the production of MMP 2 was not significantly changed by IL 1beta treatment . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : IL 1 beta decreased the accumulation of aggrecan , hyaluronan and type 2 collagen in the CAM and increased intracellular MMP 1 , 3 and 13 at a concentration of 100 pg / ml . ^^^ Intracellular MMP 1 , 3 , 13 and TIMP 1 and 3 of IL 1 beta treated cells was downregulated after treatment with hydrocortisone . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| IL 1beta induced a substantial output of both MMP 1 and MMP 3 into cell supernatants , reflecting increases ( typically 100 fold ) in MMP mRNA , but had only minor effects on MMP 2 expression . ^^^ Ciprofloxacin also potentiated IL 1beta stimulated MMP 1 mRNA expression , but did not potentiate the output of MMP 1 , and had no significant effects on MMP 2 mRNA expression or output . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Endogenous Bcl 3 expression was required for IL 1beta induction of MMP 1 gene expression . ^^^ We showed previously that NF kappaB 1 contributes to IL 1beta induction of MMP 1 transcription in stromal cells . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Trophoblast proteases , matrix metalloproteases ( MMP 2 , MMP 9 ) , membrane type matrix metalloproteases ( MT MMP 1 & 2 ) and urokinase type plasminogen activator ( uPA ) were found to be up regulated by IL 1beta while the protease inhibitors , tissue inhibitor of metalloproteases ( TIMP 1 & 2 ) and plasminogen activator inhibitors ( PAI 1 & 2 ) to be up regulated by TGF beta 1 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| IL 1 beta induces COX 2 , MMP 1 , 3 and 13 , ADAMTS 4 , IL 1 beta and IL 6 in human tendon cells . ^^^ IL 1 beta ( 1 nM ) induced mRNAs for cyclooxygenase 2 ( COX 2 ) , MMP 1 , 3 , 13 and aggrecanase 1 as well as IL 1 beta and IL 6 , whereas mRNAs for COX 1 and MMP 2 were expressed constitutively . ^^^ IL 1 beta also stimulated MMP 1 and 3 protein secretion . ^^^ Induction of MMP 1 and 3 was detectable at 10 pM IL 1 beta . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| METHODS : A total of 96 patients with UC and 106 ethnically matched controls were genotyped at polymorphic sites in IL 1beta , matrix metalloproteinase 1 ( MMP 1 ) , matrix metalloproteinase 3 ( MMP 3 ) , and inducible nitric oxide synthase ( iNOS ) genes , using polymerase chain reaction ( PCR ) based methods . ^^^ RESULTS : There was no significant difference in genotype distributions of IL 1beta , MMP 1 , MMP 3 , and iNOS genes between controls and UC patients in a Japanese population . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The levels of interleukin ( IL ) 1alpha , IL 1beta , IL 6 , IL 8 , matrix metalloproteinase ( MMP ) 1 , MMP 2 , MMP 9 , tissue inhibitors of matrix metalloproteinase ( TIMP ) 1 , TIMP 2 , granulocyte elastase , and fetal fibronectin in cervical diluted specimens were measured by immunoassay , and the uterine cervix was assessed by transvaginal ultrasonography . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| With IL 1beta or TNFalpha above 10 pg / mL stimulation , 17beta estradiol demonstrated no effect on MMP 1 , MMP 3 , MMP 13 , or TIMP 1 secretion . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Administration of anti IL 1beta just before injury and without bacterial infection resulted in a significant reduction in expression of MMP 2 ( at 8 hours ) , MMP 9 ( at 8 hours ) , TIMP 1 ( at 8 and 72 hours ) , and TIMP 2 ( at 8 hours ) . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Stretching induced IL 1beta , cyclooxygenase 2 ( COX 2 ) , and MMP 3 genes but not MMP 1 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To study the inhibitory effects of hyaluronan ( HA ) on the production of matrix metalloproteinase 1 ( MMP 1 ) by rheumatoid synovial fibroblasts ( RSF ) stimulated by proinflammatory cytokines , tumor necrosis factor a ( TNF a ) , and interleukin 1beta ( IL 1beta ) . ^^^ RESULTS : Treatment with HA ( 0 . 3 approximately 3 . 0 mg / ml ) resulted in a significant decrease in the production of MMP 1 induced by TNF a and IL 1beta , in a dose dependent manner . ^^^ Pretreatment with OS / 37 reversed the inhibition of MMP 1 production in TNF a or IL 1beta stimulated RSF caused by HA . ^^^ CONCLUSION : HA suppresses the production of MMP 1 by TNF a or IL 1beta stimulated RSF . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : This study investigated the regulated expression of collagenases ( MMP 1 , 8 , and 13 ) and stromelysins ( MMP 3 , 10 , and 11 ) by human corneal epithelial cells treated with IL 1 beta , TNF alpha , and doxycycline , a medication used to treat ocular surface diseases . ^^^ RESULTS : Semiquantitative RT PCR and Northern hybridization revealed that the mRNAs of MMP 1 , 13 , 3 , 10 , and 11 were dose dependently upregulated by IL 1 beta and TNF alpha , whereas MMP 8 and 14 and tissue inhibitor of metalloproteinase ( TIMP ) 1 were not altered , in corneal epithelial cells . ^^^ MMP ELISA and activity assays confirmed this dose dependent increase in MMP 1 , 13 , 3 , and 10 protein production in conditioned media by IL 1 beta and TNF alpha . ^^^ CONCLUSIONS : This study demonstrated that IL 1 beta and TNF alpha upregulate collagenases ( MMP 1 , 13 ) and stromelysins ( MMP 3 , 10 , and 11 ) in human corneal epithelial cells . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Overexpression of IL 1beta resulted in augmentation of expression of the cytokines , ICAM 1 , and matrix metalloproteinase 2 ( MMP 2 ) . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The aim of the present study was to evaluate the regulation of MMP 2 ( gelatinase A ) and MMP 3 ( stromelysin ) produced by cultured ovine nucleus pulposus ( NP ) cells stimulated with interleukin 1beta ( IL 1beta ) . ^^^ Time course and dose dependencies were established for MMP 2 , 3 production by the NP cells in response to the IL 1beta . ^^^ IL 1beta was a potent catabolic mediator for the NP cells , resulting in the production of elevated levels of MMP 2 and 3 in culture . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In the present study , we investigated the effects of decorin on the production of metalloproteinases ( MMP 1 , 2 , 3 , 9 and 13 ) , tissue inhibitors of metalloproteinases ( TIMP 1 , 2 ) and cytokines ( TGF beta , IL 1beta , IL 4 and TNF alpha ) . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Both TIMP 1 and MMP 1 showed positive correlation with each other and with previously determined levels of mRNA for both interleukin 1beta ( IL 1beta ) and IL 6 in this patient series when considering all patients individually , but neither correlated with tumor necrosis factor alpha . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Gene expressions of type 1 and 2 collagen , metalloproteinase 1 and 3 ( MMP 1 and 3 ) , and tissue inhibitor of metalloproteinase 1 ( TIMP 1 ) as well as the IL 1beta induced gene expressions of MMP 1 and 3 were analyzed by reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ The effects of DHEA on the gene expressions of MMP 1 and 3 were more prominent in the presence of IL 1beta , in which DHEA suppressed not only MMP 1 , but also MMP 3 at the lower concentrations , 10 and 50 micro M , respectively . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To observe the effect of different dose of estrogen or estrogen plus progestin on the mRNA expression of MMP 1 , MMP 3 , TIMP 1 and IL 1beta in synovia of female New Zealand White rabbit OA model . ^^^ Reverse transcription polymerase chain reaction were used to detect the mRNA expression of MMP 1 , MMP 3 , TIMP 1 and IL 1beta in the OA synovia to determine the effect of estrogen and progestin . ^^^ RESULTS : RT PCR shows an increase expression of mRNA of MMP 1 , MMP 3 and IL 1beta in OA synovia tissue in ovariectomized rabbits . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| MMP 1 and TIMP 1 mRNA expression were markedly increased with IL 6 and TNF alpha treatment and remains unchanged with IL 1beta . ^^^ Pro MMP 1 protein levels are unchanged with TNF alpha and significantly increased with IL 1beta and IL 6 treatment . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Addition of TIMP 1 or 2 resulted in decreases in matrix metalloproteinase ( MMP ) 3 concentrations of 37 and 41 % , and MMP 1 immunoreactivity of 32 and 36 % , respectively , compared with the IL 1 beta group , on day 9 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Furthermore , a HA induced increase in interleukin 1beta ( IL 1beta ) , a potent inducer of MMP 1 gene expression , was demonstrated in Hs578T cells at 2 and 4 h . ^^^ Treatment with phosphocitrate ( PC ) ( a naturally occurring inhibitor of calcium phosphate crystallisation , which is known to block a number of HA induced biological effects in other cell types ) blocked HA mediated mitogenesis , as well as , COX 2 , MMP 1 and IL 1beta induction , at the transcriptional level . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Studies with specific inhibitors of MAPKs showed that p 38 MAPK activation was necessary for both IL 1 beta and MMP 1 induction , but Erk activation was required only for MMP 1 induction . ^^^ These results indicated that induction of MMP 1 by alpha 3 LG 4 is mediated through the IL 1 beta autocrine loop in keratinocytes but the mechanism of the induction in fibroblasts is different . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In the present study , we investigated MMP 1 secretion from human pancreatic periacinar myofibroblasts in response to pro inflammatory cytokines IL 1beta and TNF alpha . ^^^ In contrast , SB 203580 ( p 38 MAPK inhibitor ) , GF109203X ( PKC inhibitor ) , and PDTC ( NF kappaB inhibitor ) did not alter the MMP 1 secretion induced by IL 1beta and TNF alpha . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| A significant relationship was also found between IL 1beta and elevated levels of MMP 2 , MMP 9 and total MMPs in the endometrial polyp group . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| EGCG also inhibited the IL 1beta induced mRNA and protein expression of MMP 1 and MMP 13 in human chondrocytes . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry for leukocytes , IL 1 beta and MMP 1 was performed on aortic valves with ( n=6 ) and without ( n=6 ) calcification obtained at valve replacement or autopsy . ^^^ Stenotic valves showed marked leukocyte infiltration and associated expression of IL 1 beta and MMP 1 . ^^^ In control valves only scattered leukocytes , low staining for MMP 1 and no staining for IL 1 beta were present . ^^^ Double label immunostaining localized IL 1 beta expression mainly to leukocytes and MMP 1 expression to myofibroblasts . ^^^ Stimulation of cultured human aortic valve myofibroblasts with IL 1 beta lead to a time dependently increased expression of MMP 1 and MMP 2 by Western blotting and zymography , whereas MMP 9 remained unchanged . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| IL 1beta and TNF alpha stimulated FLSC extracellular signal regulated kinase ( ERK ) activation as well as MMP 1 and 13 release . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The IL 1beta induced expression of MMP 1 , 2 , 3 , and 9 by corneal fibroblasts was inhibited by triptolide at the protein or mRNA level . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Atherosclerotic changes ( plaque formation , lipid and macrophage rich intimal thickening , the increase in MCP 1 , IL 8 , TNF alpha , IL 1beta , M CSF , MMP 1 , MMP 9 , MMP 12 , and ACE mRNA expression , and the increase in plasma MCP 1 levels ) were observed in the high cholesterol diet group ( HC ) . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Inhibition of PKC zeta using PKC zeta pseudosubstrate inhibited IL 1beta stimulated increases in MMP 2 and MMP 9 activities . ^^^ These observations suggest that OPN , acting via beta 3 integrins , inhibits IL 1beta stimulated increases in MMP 2 and MMP 9 activity , at least in part , via the involvement of PKC zeta . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| We investigated the circulating levels of the main cytokines involved in bone resorption ( IL 1beta , IL 6 , TNF alpha ) , prostaglandins ( PGE 2 ) and metalloproteases ( MMP 1 ) , as possible early markers of osteolysis , in the serum of eight patients with periprosthetic osteolysis and ten patients without osteolysis . ^^^ The mean serum levels of IL 1beta , IL 6 , TNF alpha , TGF beta , MMP 1 , and PGE 2 in patients with periprosthetic osteolysis did not differ significantly from those of patients without osteolysis or from those of normal controls . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : This study demonstrates that HA effectively inhibits IL 1beta stimulated production of MMP 1 , MMP 3 , and MMP 13 , which supports the clinical use of HA in the treatment of OA . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Dexamethasone significantly reduced IL 1 beta , IL 6 , COX 2 , and MMP 1 expression at high cell density . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To evaluate Fcgamma receptor ( FcgammaR ) expression on synovial macrophages from rheumatoid arthritis ( RA ) patients and to determine whether this expression correlates with the production of the proinflammatory cytokines tumor necrosis factor alpha ( TNFalpha ) , interleukin 1beta ( IL 1beta ) , IL 12 , and matrix metalloproteinase 1 ( MMP 1 ) . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1beta ( IL 1beta ) , which is increased in the heart following myocardial infarction , increases expression and activity of MMP 2 ( gelatinase A ) and 9 ( gelatinase B ) in cardiac fibroblasts . ^^^ Using adult rat cardiac fibroblasts , we show that inhibition of ERK1 / 2 and JNKs inhibits IL 1beta stimulated increases in MMP 9 , not MMP 2 , expression and activity . ^^^ Inhibition of PKC theta and PKC zeta using pseudosubstrates inhibited IL 1beta stimulated activation of ERK1 / 2 and JNKs and the expression and activity of MMP 2 and 9 . ^^^ SN 50 , NF kappaB inhibitor peptide , inhibited IL 1beta stimulated increases in MMP 2 and 9 expression and activity . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| IL 1beta is known promote cyclooxygenase 2 ( COX 2 ) and matrix metalloproteinase 2 ( MMP 2 ) expression . ^^^ This study focuses on the characterization of the signaling cascade associated with IL 1beta induced matrix metalloproteinase 2 ( MMP 2 ) regulation in human chondrocytes . ^^^ The decrease in collagen levels in the conditioned media was prevented by a broad spectrum MMP inhibitor , suggesting that IL 1beta promotes the proteolytic process leading to MMP 2 activation . ^^^ IL 1beta related MMP 2 expression was found to be dependent on prostaglandin E 2 ( PGE 2 ) production . ^^^ However , there is no cross talk between PKC and p 38 MAPK in the IL 1beta induced MMP 2 activation . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| EGCG reduced this stimulation , by 20 30 % at 2 . 5 microM and more than 80 % at 25 microM , and had a smaller effect on MMP 2 mRNA expression , which was not stimulated by IL 1beta . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Although no suppressive effect was demonstrated on MMP 2 , A 77 1726 markedly inhibited MMP 1 , 3 , and 13 secretions from IL 1beta stimulated rheumatoid synovial fibroblasts . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Cytokine ( TNF alpha , IL 1beta , IL 6 and IL 10 ) and metalloproteinase ( MMP 2 and MMP 9 ) release as well as their inhibitors ( TIMP 1 and TIMP 2 ) were assessed after time course incubation with different amount of nanoparticles . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Cytomix ( tumor necrosis factor alpha , IL 1beta , and IFN gamma ) treatment showed that the activity of matrix metalloproteinase 2 ( MMP 2 ) was increased in lung fibroblasts from EGR 1 control ( + / + ) mice but not detected in that of EGR 1 null ( / ) mice , whereas MMP 9 was regulated by EGR 1 in a reverse manner . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The objective of this study was to determine the quantitative expression levels as well as the distribution in normal and osteoarthritic cartilage of gelatinase A and in cultured articular chondrocytes with and without stimulation by Il 1beta . ^^^ Of note , no significant up regulation of gelatinase A was observed by Il 1beta in vitro . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Matrix metalloprotease 1 ( MMP 1 ) and MMP 3 mRNA were increased by IL 1beta in normoxia and hypoxia , whereas only MMP 3 mRNA was enhanced in reoxygenated cultures . ^^^ The MMP 2 mRNA level was not significantly affected by IL 1beta in normoxia or hypoxia , whereas it was enhanced in reoxygenated cultures . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| MMP 1 was up regulated in Caco 2 cells by TGF beta , EGF , and IL 1 beta , but only by EGF in WiDR cells . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : IM7 . 8 . 1 decreased iNOS mRNA levels and the activity of both MMP 9 and MMP 2 eight h after injection into zymosan air pouch while IM7 . 8 . 1 , HMW HA and LMW HA had no effect on IL 1 beta or TNF alpha mRNA levels . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The results showed that the combination of hypoxia and IL 1beta caused a significant increase of MMP 1 , MMP 3 , MMP 9 and MMP 13 mRNA ( P < 0 . 05 ) . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| PGEs enhanced Erk activation and MMP 1 secretion in response to EGF but inhibited Erk and MMP 1 when TNF alpha and IL 1beta were the stimuli , indicating that the effects of PGEs on gastric cell responses are context dependent . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to investigate whether there are different effects of low and high concentrations of IL 1beta on the expression level of anabolic genes ( type 2 collagen , aggrecan ) , catabolic genes ( matrix metalloproteinase 1 [ MMP 1 ] , MMP 2 , MMP 3 , MMP 13 , and ADAMTS 4 ) , and cytokines ( IL 1beta , IL 6 , and leukemia inhibitory factor [ LIF ] ) by articular chondrocytes ( normal and osteoarthritic ) . ^^^ RESULTS : In normal adult articular chondrocytes the expression of both aggrecan and type 2 collagen genes was significantly down regulated , whereas matrix degrading proteases ( except MMP 2 ) , as well as the investigated cytokines , were induced by IL 1beta in a dose dependent manner . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Expression of MMP 1 and MMP 3 mRNAs was induced by IL 1beta . ^^^ The IL 1beta mediated induction of MMP 1 mRNA expression was attenuated by 10 microg / ml HA ( p=0 . 026 ) and that of MMP 3 mRNA was strongly down regulated in the presence of 10 or 1000 microg / ml HA ( p < 0 . 001 ) . ^^^ These data suggest that HA inhibits the expression and production of MMP 1 and MMP 3 in IL 1beta stimulated human synovial cells . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| We comprehensively investigated the involvement of mitogen activated protein kinases ( MAPKs ) / activator protein 1 ( AP 1 ) and IkappaB kinases ( IKKs ) / IkappaBs / nuclear factor kappaB ( NF kappaB ) in IL 1beta stimulated IL 6 , IL 8 , prostaglandin E ( 2 ) ( PGE ( 2 ) ) and matrix metalloproteinase 1 ( MMP 1 ) production by human gingival fibroblasts ( HGF ) . ^^^ Further , IL 1beta stimulated HGF to produce IL 6 , IL 8 , PGE ( 2 ) and MMP 1 via activation of the 3 MAPKs and NF kappaB , as inhibitors of each MAPK and NF kappaB significantly suppressed the production of IL 1beta stimulated factors , though these pathways might also play distinct roles in IL 1beta activities . ^^^ Our results strongly suggest that the MAPKs / AP 1 and IKK / IkappaB / NF kappaB cascades cooperatively mediate the IL 1beta stimulated synthesis of IL 6 , IL 8 , PGE ( 2 ) and MMP 1 in HGF . . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The effects of beta END and Nal on mRNA expression of several cytokines in the synovial cells , including tumor necrosis factor alpha ( TNF alpha ) , interleukin 1beta ( IL 1beta ) , IL 6 , regulated upon activation normal T cell expressed and secreted ( RANTES ) , inducible nitric oxide synthase ( iNOS ) , matrix metalloproteinase 2 ( MMP 2 ) and MMP 9 were estimated by quantitative reverse transcription polymerase chain reaction . ^^^ RESULTS : 75 % of the rats were demonstrated to have established the CIA model successfully . beta END was shown to exert multiple effects on synovial cells of CIA rats including decreased proliferation , induced apoptosis , and downregulation of TNF alpha , IL 1beta , IL 6 , RANTES , iNOS , MMP 2 and MMP 9 mRNA expression . beta END seemed to play an immunoregulating role by downregulating the activity and expression of NF kappaB . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The expression of IL 1beta , IL 6 , TGF beta isoforms , ANF , and components of the extracellular matrix ( pro collagen 1 and 3 , colligin , MMP 2 and TIMP 2 ) was measured by ribonuclease protection assay . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| FK 506 had no detectable effects on IL 1beta induced MMP 2 induction . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Significantly higher ISIs were also recorded for MMP 1 ( 16 . 14 + / 8 . 49 vs . 1 . 13 + / 1 . 79 ; P < 0 . 0001 ) , IL 1beta ( 62 . 62 + / 27 . 23 . 97 vs . 1 . 61 + / 1 . 27 ; P < 0 . 0001 ) , IL 8 ( 37 . 91 + / 21 . 18 vs . 4 . 24 + / 3 . 60 ; P < 0 . 0001 ) , and VEGF ( 81 . 67 + / 26 . 22 vs . 19 . 40 + / 16 . 85 ; P = 0 . 0001 ) . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The effects of VIP and [ D P Cl Phe ( 6 ) , Leu ( 17 ) ] VIP on mRNA expression of several cytokines in the synovial cells including tumor necrosis factor alpha ( TNF alpha ) , interleukin 1beta ( IL 1beta ) , interleukin 6 ( IL 6 ) , regulated upon activation , normal T cell expressed and secreted ( RANTES ) , inducible NO synthase ( iNOS ) , matrix metalloproteinase 2 ( MMP 2 ) and MMP 9 were estimated by quantitative reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ |
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| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Furthermore , quantitative real time PCR indicated that the increased secretion of MMP 1 , IL 1beta , and IL 6 was due to increased mRNA expression . ^^^ Results showed that blocking of either NF kappaB or MAPK pathways led to the inhibition of MMP 1 , IL 1beta , and IL 6 expression stimulated by sodium lactate , LPS , or both . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the productions of IL 6 , COX 2 , MMP 1 , and MMP 3 were upregulated as a result of the increasing concentration of IL 1beta in a positive feedback loop of IL 1beta . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In both cell systems matrix metalloproteinase 1 ( MMP 1 ) , MMP 3 and MMP 13 were strongly induced by IL 1beta , without significant induction of MMP 2 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Both H ( 2 ) O ( 2 ) and IL 1beta down regulated type 2 collagen and aggrecan expression and increased that of MMP 1 and 3 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| We previously demonstrated that the LG 4 module of laminin alpha 3 chain ( alpha 3 LG4 ) induces a matrix metalloproteinase 1 ( MMP 1 ) expression through the interaction with syndecans leading to MAPK activation / IL 1beta expression signaling loop ( Utani et al . , J . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The expression of MMP 1 , 2 , and 3 increased markedly in the presence of IL 1beta after day 21 of culture . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| MMP 2 and 3 activities also increased significantly in the IL 1beta treated group . ^^^ However , MMP 2 or MMP 3 activities were not markedly altered by IL 1beta treatment compared with controls . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : Eighteen consecutive breast cancer patients with bone metastases were evaluated for circulating levels of vascular endothelial growth factor ( VEGF ) , basic fibroblast growth factor ( bFGF ) , metalloproteinase 1 ( MMP 1 ) , metalloproteinase 2 ( MMP 2 ) , interleukins 1beta , 6 and 8 ( IL 1beta , IL 6 , IL 8 ) , interferon gamma , tumor necrosis factor alpha ( TNF alpha ) and transforming growth factor beta 1 just before and 2 and 7 days after ZA infusion . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The menisci were harvested and glycosaminoglycans ( GAG ) , interleukin 1beta ( IL 1beta ) , matrix metalloproteinase 1 ( MMP 1 ) , cyclooxygenase 2 ( COX 2 ) , and interleukin 10 ( IL 10 ) were determined by histochemical analysis . ^^^ The expression of proinflammatory mediators MMP 1 , COX 2 , and IL 1beta was notably increased within 24 h and continued to increase during the next 24 h in immobilized knees . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| At the cellular level , PFE ( 6 . 25 25 mg / L ) inhibited the IL 1beta induced expression of MMP 1 , 3 , and 13 protein in the medium ( P < 0 . 05 ) and this was associated with the inhibition of mRNA expression . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : MMP 13 was expressed by tendon cells at lower levels than MMP 1 , and was stimulated typically 10 to 100 fold by IL 1beta . ^^^ In contrast , ciprofloxacin and norfloxacin increased basal and IL 1beta stimulated MMP 1 mRNA expression . ^^^ Both the inhibition of MMP 13 and the potentiation of MMP 1 expression by fluoroquinolones were accompanied by corresponding changes in IL 1beta stimulated MMP output . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In fibroblast cultures IL 1beta was a potent stimulus for MMP 3 , whereas TNF alpha was more potent for MMP 1 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction was performed to determine mRNA levels of matrix metalloproteinases ( MMP 1 , 3 , 13 ) , aggrecanases ( 1 , 2 ) , IL 1beta , inducible nitric oxide synthase , cyclooxygenases ( 1 , 2 ) , type 2 collagen and aggrecan , and transforming growth factor beta ( TGF beta 1 , 2 , 3 ) and their receptors 1 and 2 . ^^^ RESULTS : Pretreatment with 0 . 5 microM Se met prevented IL 1beta induced MMP 1 and aggrecanase 1 expression , and reduced the cytokine inhibitory effect on type 2 collagen , aggrecan core protein , and TGF beta receptor 2 ( TGF betaRII ) mRNA levels . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Repetitive mechanical stretching modulates IL 1beta induced COX 2 , MMP 1 expression , and PGE 2 production in human patellar tendon fibroblasts . ^^^ In the absence of stretching , it was found that 10 pM of IL 1beta markedly induced higher levels of COX 2 , MMP 1 gene expression , and PGE 2 production than non treated cells . ^^^ Furthermore , cells with 4 % stretching decreased the COX 2 and MMP 1 gene expression and PGE 2 production that were stimulated by IL 1beta , whereas cells with 8 % stretching further increased these gene products and / or expression levels in addition to the effects of IL 1beta stimulation . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Estrogen administration significantly increased the levels of IL 1beta , IL 6 , IL 8 , and GM CSF mRNAs , as well as MMP 2 , 7 , and 9 mRNAs , compared with those of placebo treated controls . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| IL 1alpha and IL 1beta promoted MMP 1 but not MMP 2 production in UVA irradiated fibroblasts . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Fibrochondrocytes expressed mRNA for MMP 2 , 3 , 7 , 8 , 9 , 11 , 13 , 14 , 16 , 17 , and 19 as well as TIMP 1 , 2 , and 3 , IL 1beta induced a significant ( P < 0 . 05 ) upregulation of mRNA for MMP 3 , 7 , 8 , 9 , 13 , 16 , 17 , and 19 . ^^^ However , MMP 2 , 11 , 14 , and TIMPs were not affected by either IL 1beta or tensile strain . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Levels of IL 1alpha , IL 1beta , and IL 6 were measured in 10 of 11 specimens , and MMP 1 , MMP 3 , and MMP 8 levels were measured in 7 of 11 specimens . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| ATP , adenosine , and UTP significantly stimulated MMP 2 release in the presence of IL 1beta ( 300 nM ATP : 181 + / 22 % , P = 0 . 003 ; 30 microm adenosine : 244 + / 150 % , P = 0 . 001 ; and 200 microm UTP : 153 + / 40 % , P = 0 . 015 ; vs . 100 % constitutive ) . ^^^ ATP also stimulated MMP 2 release in the absence of IL 1beta ( 100 microm ATP : 148 + / 38 % vs . 100 % constitutive ) . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| We investigated MMP 2 activation pathways and found an early increase in mRNA levels of soluble inflammatory mediators ( TNF alpha and IL 1beta ) . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| MMP 1 synthesis in the resident cells of arthritic joints is regulated via two major cytokines , IL 1beta and TNF alpha . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor alpha ( TNF alpha ) , interleukin 1beta ( IL 1beta ) , interleukin 6 ( IL 6 ) , regulated upon activation , normal T cell expressed and secreted ( RANTES ) , inducible NO syntheses ( iNOS ) , matrix metalloproteinase 2 ( MMP 2 ) and MMP 9 mRNA expression of synovium tissues of CIA rats was estimated by quantitative RT PCR . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Relation of eight SNPs ( tumor necrosis factor alpha [ TNF alpha ] 1031 T / C , interleukin 10 [ IL 10 ] 819 T / C , IL 1beta 511 C / T , IL 6 634 C / G , IL 18 607 A / C , transforming growth factor beta [ TGF beta ] +869 C / T , matrix metalloproteinase 1 [ MMP 1 ] 1607 1G / 2G , and MMP 3 1171 5A / 6A ) with age or gender was evaluated in 500 Japanese persons ( mean age : 56 . 7 years old , range : 19 100 ) by the chi square test . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Production of MMP 1 and MMP 3 by RSF was stimulated by IL 1beta . ^^^ CONCLUSION : HA suppresses IL 1beta enhanced MMP 1 and MMP 3 synthesis in RSF via ICAM 1 through down regulation of NF kappaB and p 38 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| IL 1beta activates articular chondrocytes to produce matrix metalloproteinase 1 ( MMP 1 ) , an enzyme capable of dismantling the collagen scaffold of articular cartilage . ^^^ These studies identified an IL 1beta responsive region of the human MMP 1 promoter that contains a consensus CCAAT enhancer binding protein ( C / EBP ) binding site . ^^^ Deletion of this site reduced overall transcriptional activity of the MMP 1 promoter , as well as decreased fold induction by IL 1beta . ^^^ IL 1beta stimulation of chondrocytes increased binding of C / EBP beta to the MMP 1 C / EBP site . ^^^ We further show that PD 98059 reduces IL 1beta induced MMP 1 mRNA expression in chondrocytes . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Pretreatment of the ic IL 1ra transfected cells with antisense oligonucleotide directed against the mRNA of icIL 1ra restored MMP 1 expression induced by stimulation with IL 1beta . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| TAK 1 downregulation reduces IL 1beta induced expression of MMP 13 , MMP 1 and TNF alpha . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : After labeling with these maghemite nanoparticles , HGF increased secretion of IL 1beta at D 1 , probably inducing the increase of MMP 1 , 2 , and 3 and TIMP 2 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| IL 1beta induced MMP 1 production by culture derived fibroblasts was determined with an MMP 1 immunoassay kit . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Measurement of astrocyte MMP protein levels showed that TGF beta combined with IL 1beta increased MMP 2 and decreased proMMP 1 expression compared to IL 1beta alone . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| IL 1beta stimulated MMP 1 ( 5 . 6 fold ) , MMP 2 ( 2 . 8 fold ) , and MMP 3 ( 75 fold ) gene expression , but not EMMPRIN , over levels in control cells ( P < 0 . 05 ) . ^^^ Both EMMPRIN and IL 1beta treatments stimulated MMP 1 , 2 , and 3 , but not EMMPRIN protein secretion , with 0 . 5 microg / ml producing the greatest response . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : CloF counteracted IL 1beta induced 35S proteoglycan degradation , gelatinolytic activity , and MMP 1 , 3 , and 13 mRNA expression . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In primary cultures , 17beta estradiol caused a significant decrease of IL 6 and IL 8 gene expression , but had no effect on the levels of IL 1beta , MMP 2 , and MMP 9 gene expression . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Serum alanine aminotransferase , histologic changes , gelatinolytic activity , MMP 2 and MMP 9 activities , tissue inhibitor of metalloproteinase 2 ( TIMP 2 ) messenger RNA ( mRNA ) levels , and mRNA and serum levels of tumor necrosis factor alpha ( TNFalpha ) and interleukin 1beta ( IL 1beta ) were measured in both groups . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To evaluate the efficacy of epigallocatechin 3 gallate ( EGCG ) , a potent antiinflammatory molecule , in regulating interleukin 1beta ( IL 1beta ) induced production of the chemokines RANTES ( CCL 5 ) , monocyte chemoattractant protein 1 ( MCP 1 / CCL2 ) , epithelial neutrophil activating peptide 78 ( ENA 78 / CXCL5 ) , growth regulated oncogene alpha ( GROalpha / CXCL1 ) , and matrix metalloproteinase 2 ( MMP 2 ) activity in rheumatoid arthritis ( RA ) synovial fibroblasts . ^^^ Zymography showed that EGCG blocked constitutive , IL 1beta induced , and chemokine mediated MMP 2 activity . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| IL 1beta also increased release of MMP 2 activity from aortic tissue . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Our results showed that IL 1beta stimulated MMP 1 protein secretion and mRNA levels in a time dependent manner ( P < 0 . 05 ) , MMP 2 mRNA in a time dependent manner and MMP 3 in a time and dose dependent manner . ^^^ Neither IL 1beta nor TNF alpha treatment affected MMP 2 protein secretion . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Transforming growth factor beta 1 ( TGF beta 1 ) upregulated gelatinase A and matrilysin genes in some cell lines , and there were no clear responses from any MMP and TIMP genes to interleukin 6 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| MMP 1 , MMP 3 , and TIMP 1 expression and synthesis were induced in cultured human synoviocytes with recombinant human interleukin 1 beta in the absence or presence of either chemical inhibitors of protein kinase A and C ( PKA , PKC ) , or prostaglandin E 2 , or cyclic AMP ( cAMP ) mimetics . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| None of the cytokines tested ( transforming growth factor beta 1 , interleukin 1 beta , basic fibroblast growth factor , tumor necrosis factor alpha , interferon gamma ) were able to regulate MMP 2 expression in cultured wound fibroblasts . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Rat mucosal keratinocytes serially propagated under permanently serum free conditions responded to interleukin ( IL ) 1 beta / IL alpha and to transforming growth factor ( TGF ) alpha / epidermal growth factor ( EGF ) ( as well as to 12 O tetradecanoylphorbol 13 acetate ( TPA ) ) by upregulation of M ( r ) 95 , 000 gelatinase ( MMP 9 ) ( M ( r ) 95K GL ) and fibroblast type collagenase ( MMP 1 ) ( FIB CL ) , whereas control cells expressed barely detectable levels of either of these enzymes . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 beta , tumor necrosis factor alpha and lipopolysaccharide were potent stimulators of matrix metalloproteinase 2 ( gelatinase A ) and matrix metalloproteinase 9 ( gelatinase B ) in cultured rat astrocytes ; the effect of each secretagogue was inhibited in the presence of glucocorticoid . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Recombinant human CD40L ( rCD40L ) induced de novo synthesis of MMP 1 , MMP 3 , and MMP 9 on vascular SMCs and stimulated the expression of these enzymes to a greater extent than did maximally effective concentrations of tumor necrosis factor alpha or interleukin 1beta , established agonists of MMP expression . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In contrast , treatment with transforming growth factor beta 1 ( TGFbeta 1 ) resulted in down regulation of matrix metalloproteinase 1 ( MMP 1 ) and MMP 13 concomitant with a reduction in the levels of mRNA for IL 1RI , IL 1RII , TNFRI , and TNFRII and proinflammatory cytokine levels . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In vitro activation of CNS endothelium with the pro inflammatory cytokines , tumour necrosis factor alpha and interleukin 1beta , resulted in selective upregulation of MMP 9 activity , whereas no significant changes were seen in MMP 2 or TIMP 2 levels at 24 h . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| A wide spectrum of MMPs , including MMP 1 and 3 which were increased in the presence of interleukin 1 beta , was detected in this cell line . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Colorectal wound fluid samples showed significantly ( p < 0 . 05 ) greater levels of the matrix metalloproteinases ( MMP 1 , 2 , 3 , and 9 ) , tissue inhibitor of metalloproteinases 1 , urokinase plasminogen activator receptor and the inflammatory cytokines ( interleukin 1beta , 6 , and tumor necrosis factor alpha ) ; e . g . , matrix metalloproteinase 3 colon ; median 275 ( range 11 2 . 530 ) ng / ml ; breast ; 530 400 . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In rat mesencephalic CSM14 . 1 cells stably expressing expanded ataxin 3 , we found a significant upregulation of mRNAs encoding the endopeptidase matrix metalloproteinase 2 ( MMP 2 ) , the transmembrane protein amyloid precursor protein , the interleukin 1 receptor related Fos inducible transcript , and the cytokine stromal cell derived factor 1alpha ( SDF1alpha ) . ^^^ Immunohistochemical studies of the corresponding or associated proteins in human SCA 3 brain tissue confirmed these findings , showing increased expression of MMP 2 and amyloid beta protein ( Abeta ) in pontine neurons containing nuclear inclusions . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Unexpectedly we found that recombinant rat SP D dodecamers selectively induce the biosynthesis of collagenase 1 ( MMP 1 ) , stromelysin ( MMP 3 ) , and macrophage elastase ( MMP 12 ) without significantly increasing the production of tumor necrosis factor alpha and interleukin 1beta . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : To determine concentrations of matrix metalloproteinase ( MMP ) 2 and 9 in synovial fluid ; and mRNA expression of MMP 1 , 13 , and 3 ; interleukin [ IL ] 1alpha and beta ; and tumor necrosis factor ( TNF ) alpha in synovial membrane and articular cartilage from horses with naturally occurring joint disease . ^^^ Synovial membrane and articular cartilage mRNA expression for MMP 1 , 3 , and 13 , IL 1alpha and beta , TNF alpha , type 2 collagen , and aggrecan were analyzed , using quantitative reverse transcriptase polymerase chain reaction . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The Cyr 61 regulated genes fall into several groups known to participate in processes important for cutaneous wound healing , including : 1 ) angiogenesis and lymphogenesis ( VEGF A and VEGF C ) ; 2 ) inflammation ( interleukin 1beta ) ; 3 ) extracellular matrix remodeling ( MMP 1 , MMP 3 , TIMP 1 , uPA , and PAI 1 ) ; and 4 ) cell matrix interactions ( Col1alpha1 , Col1alpha2 , and integrins alpha ( 3 ) and alpha ( 5 ) ) . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical staining assessed ( 1 ) cell phenotype using antibodies to alpha actin ( microfilaments ) , vimentin and desmin ( intermediate filaments ) , smooth muscle myosin ( SM 1 ) , and SMemb ( a nonmuscle myosin produced by activated mesenchymal cells ) and ( 2 ) the expression of proteolytic activity using antibodies to collagenases ( matrix metalloproteinase [ MMP ] 1 , MMP 13 ) , gelatinases ( MMP 2 , MMP 9 ) , cysteine endoproteases ( cathepsin S and K ) , and interleukin 1beta , a cytokine that can induce secretion of proteolytic enzymes . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Matrix metalloproteinase 2 increased to a new steady state level or remained unchanged after group B streptococci inoculation or interleukin 1 beta infusion , respectively . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Both cellular and extracellular pro matrix metalloproteinase 2 protein were increased by transforming growth factor beta 1 ( P = . 01 ) and decreased by estradiol ( P < . 001 ) and ICI 182 780 ( P = . 02 and . 002 , respectively ) . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| LC treatment reduced the number of blood monocytes and decreased macrophage infiltration in the injured arteries as well as smooth muscle cell proliferation , interleukin 1beta transcription , and production and matrix metalloproteinase 2 activity . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Culture of rat cardiac fibroblasts for 24 h in 1 % oxygen enhanced MMP 2 synthesis by more than 5 fold and augmented the MMP 2 synthetic responses of these cells to endothelin 1 , angiotensin 2 and interleukin 1beta . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Interleukin 1beta , tumor necrosis factor alpha , and interleukin 6 induced the expression of matrix metalloproteinase 9 messenger RNA , whereas matrix metalloproteinase 2 expression was constitutive in control and cytokine stimulated tissues . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| These results indicate that CITED 2 plays a major role in shear induced down regulation of MMP 1 and MMP 13 via a transforming growth factor beta dependent pathway . . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Both interleukin 1beta and tumor necrosis factor alpha ( 10 ng / mL ) decreased fibrillin messenger RNA levels but increased MMP 1 , 3 and 9 synthesis markedly . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Treatment of the cells with interleukin 1beta or A 23187 synergistically increased the stimulatory effect of PMA on MMP 1 production . ^^^ CONCLUSION : The present study shows that MMP 1 and TIMP 1 production is regulated differently by interleukin 1beta and calcium in human gingival fibroblasts and that this difference is markedly amplified in the presence of the PKC activator PMA . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Discriminant analysis demonstrated statistically significant differences in ( 1 ) the determination of whether rotator cuff tear patients are separable from the NRCT group using the influential functions , the most influential of which were interleukin 1 beta , MMP 2 , and MMP 13 , and ( 2 ) the assessment of whether full thickness rotator cuff tears are distinguishable from partial tears using identical influential functions . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Reverse transcriptase real time polymerase chain reaction and immunohistochemistry assays were used to evaluate changes in transcription factors ( AP 1 , NF kappaB ) , primary cytokines ( interleukin 1beta , tumor necrosis factor alpha ) , matrix metalloproteinases ( MMP 1 , MMP 3 , MMP 9 ) , barrier repair enzymes ( acetyl coenzyme A carboxylase , 3 hydroxy 3 methylglutaryl coenzyme A reductase ) , and type 1 procollagen . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : It was found that mRNA levels for MMP 1 , MMP 3 , TIMPs , iNOS , COX 2 , interleukin 1beta in both menisci , and interleukin 6 in medial menisci were significantly elevated in tissues cultured under nonloading conditions compared to the time zero controls . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| In vitro , MMP 1 is up regulated by interleukin 1beta and tumor necrosis factor alpha , but these regulatory mechanisms are not operating in H . pylori infection as shown by inhibitory antibodies . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| This fucoidan is able to inhibit gelatinase A secretion and stromelysin 1 induction by interleukin 1beta on dermal fibroblasts in culture . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| The expression of MMPs ( MMP 1 , 2 and 9 ) and RANKL was correlated with the expression of interleukin 1beta , tumor necrosis factor alpha and interferon gamma , in a time period characterized by the intense increase of inflammatory reaction and alveolar bone loss . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| Reverse transcriptase real time polymerase chain reaction assays were used to evaluate changes in transcription factor activator protein 1 , primary cytokines ( interleukin 1beta , tumor necrosis factor alpha ) , and matrix metalloproteinases ( MMP 1 , MMP 3 , MMP 9 ) . ^^^ RESULTS : Significant increases in gene expression of the c Jun component of activator protein 1 , interleukin 1beta , tumor necrosis factor alpha , MMP 1 , MMP 3 , and MMP 9 were found with crystal abrasion combined with negative pressure . ^^^ |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|