| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| The in vitro effects of the beta 2 adrenoceptor agonists ( 1 10 10 ( 9 ) 10 ( 5 ) M ) , terbutaline , salmeterol , and formoterol , on the release of inflammatory mediators , i . e . the eicosanoids leukotriene B 4 ( LTB 4 ) and prostaglandin E 2 ( PGE 2 ) and the cytokine interleukin 1 beta ( IL 1 beta ) , were assessed in cultures of human blood monocytes . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| The density of beta AR , assayed by 125I pindolol binding , was increased two to threefold by a 24 h incubation of the cells with IL 1 alpha , IL 1 beta , and TNF alpha ( EC 50 : 2 . 7 , 8 . 2 , and 24 pM , respectively ) , although a series of other cytokines and growth factors did not have this effect . ^^^ Cortisol also increased beta AR density ( EC 50 : 30 nM ) and markedly potentiated the effects of IL 1 alpha , IL 1 beta , and TNF alpha . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| We studied the in vivo mechanism of beta adrenergic receptor ( beta AR ) hyporesponsiveness induced by intratracheal instillation of interleukin 1beta ( IL 1beta , 500 U ) in Brown Norway rats . ^^^ Thus , IL 1beta induces an attenuation of beta AR induced airway relaxation through mechanisms involving a reduction in beta ARs , an increase in Gi ( alpha ) subunit , and a defect in adenylyl cyclase activity . . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| Pretreatment with IL 1 beta had no significant effect on beta 2 adrenoceptor number assessed by [ 125I ] CYP binding in these cells , nor was there any significant effect of IL 1 beta on Gsa expression assessed by Western blot . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| This study examined the effects of human IL 1 beta on the function of the beta adrenergic receptor ( beta AR ) adenylyl cyclase ( AC ) system in BEAS 2B cells , a human airway epithelial cell line . ^^^ IL 1 beta markedly increased beta AR density ( Bmax ; P < 0 . 001 ) primarily by increasing the percentage of the beta 2AR subtype ( from 67 to 91 % ; P < 0 . 001 ) . ^^^ These data indicate that IL 1 beta mediated changes in the beta AR AC system function in airway epithelial cells are complex and involve expression of receptor protein , GTP binding protein , and possibly AC itself . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| In IL 1beta treated mice , exploration ( assessed by measuring duration and frequency of Wall Rearing and Rearing behaviors ) was nearly totally suppressed , while duration and frequency of behaviors such as Grooming , Bar Holding , and Digging were also markedly reduced . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| In this study , we established an in vivo model of beta 2 adrenoceptor desensitization in guinea pig airways by administration of IL 1beta intratracheally or chronic albuterol by inhalation . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| This paper lists the genotype frequencies of 50 polymorphisms of 37 genes ( ALDH 2 , ADRB 2 , ADRB 3 , COMT , CD 36 , CXCR 2 , CCND 1 , COX 2 , CYP2A6 , CYP 17 , CYP 19 , IGF 1 , IL 1A , IL 1B , IL 1RN , IL 1R1 , IL 6 , IL 8 , IL 10 , LEP , Le , L myc , MPO , MTR , MTHFR , MAO A , NQO 1 , OGG 1 , p 53 , p 73 , Se , SRD5A2 , TGF B , TNF A , TNF B , XPD , and XRCC 1 ) and 6 sets of combined genotype frequencies for 241 non cancer Japanese outpatients . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| This study examined the effects of chondroitin sulfate ( CS ) alone and CS plus glucosamine sulfate ( GS ) in a dietary bar formulation on inflammatory parameters of adjuvant induced arthritis and on the synthesis of interleukin 1beta ( IL 1beta ) and matrix metalloprotease 9 ( MMP 9 ) . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of inhibitory peptide ( PKI GFP ) or a mutant regulatory subunit of PKA ( RevAB GFP ) effectively inhibited intracellular PKA activity in cultured human ASM cells and enhanced beta2AR responsiveness by mitigating both agonist specific ( beta agonist mediated ) desensitization and cytokine ( IL 1beta and TNF alpha ) induced heterologous desensitization via actions on multiple targets . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| This effect of centrally administered alpha MSH 1 13 was inhibited by systemic injection of the nonspecific beta adrenergic receptor blocker propranolol and by administration of a specific beta 2 adrenergic receptor antagonist ; the effect was not altered by blockade of cholinergic , alpha adrenergic , or beta 1 adrenergic receptors . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| The induction of IL 6 release by dibutyryl cAMP indicated that IL 6 secretion secondary to beta 2 adrenergic receptor activation probably occurs through cAMP signalling pathways . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| We have shown that M 2 receptors in these cells can be down regulated by muscarinic and beta 2 adrenergic receptor agonists . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| Lower doses of procaterol , a beta 2 adrenoceptor agonist showed stronger induction of the mRNA than isoproterenol . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| We examined the effect of the beta adrenoceptor antagonist propranolol ( 3 . 4x10 ( 6 ) M ) , the beta 2 adrenoceptor antagonist ( + / ) 1 [ 2 , 3 ( Dihydro 7 methyl 1H inden 4 yl ) oxy ] 3 [ ( 1 methyl eth yl ) amino ] 2 butanol ( ICI 118551 ) ( 10 ( 7 ) M ) and the beta 1 adrenoceptor antagonist atenolol ( 10 ( 7 ) M and 10 ( 6 ) M ) on the adrenaline stimulated release of interleukin 6 . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| To further investigate mechanisms regulating beta 2 adrenergic receptor ( beta2R ) expression in lymphocytes , the influence of cytokines on the density of beta2R on purified CD4+ and CD8+ lymphocytes was determined in vitro . beta2R were determined by means of a radioligand binding assay with ( 125I ) iodocyanopindolol . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| We examined the expression and function of beta adrenergic receptor ( beta AR ) subtypes in both isolated primary rat microglia and a rat microglial cell line . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1beta differentially regulates beta 2 adrenoreceptor and prostaglandin E 2 mediated cAMP accumulation and chloride efflux from Calu 3 bronchial epithelial cells . ^^^ Here we tested the effect of interleukin 1beta , a pro inflammatory cytokine , on cAMP accumulation and chloride efflux in Calu 3 airway epithelial cells in response to ligands binding to adenylyl cyclase coupled receptors such as the beta 2 adrenoreceptor and EP prostanoid receptors . ^^^ Interleukin 1beta significantly increased isoprenaline induced cAMP accumulation by increasing beta 2 adrenoreceptor numbers via a protein kinase A dependent mechanism . ^^^ |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and P07550 |
Pubmed |
SVM Score :0.0 |
| NA |
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