| Interacting proteins: P01920 and P01308 |
Pubmed |
SVM Score :0.0 |
| Apart from genes in the HLA complex ( IDDM 1 ) and the variable number of tandem repeats in the 5 ' region of the insulin gene ( INS VNTR , IDDM 2 ) , several other loci have been proposed to contribute to IDDM susceptibility . ^^^ |
|
| Interacting proteins: P01920 and P01308 |
Pubmed |
SVM Score :0.0 |
| Offspring with these high risk IDDM 1 genotypes plus the INS VNTR class I / I genotype ( n=71 ; 6 . 3 % ) had the highest risk of developing islet autoantibodies ( 21 . 8 % by age 2 years vs 8 . 9 % in offspring with high risk IDDM 1 plus INS VNTR class I / III or III / III genotypes , p < 0 . 05 ) and T1D ( 8 . 5 % by age 6 years vs 4 . 3 % ) . ^^^ |
|
| Interacting proteins: P01920 and P01308 |
Pubmed |
SVM Score :0.0 |
| Genetic association with type 1 diabetes ( T1D ) has been established for two chromosomal regions : HLA DQ / DR ( IDDM 1 ) and INS VNTR ( IDDM 2 ) . ^^^ |
|
| Interacting proteins: P01920 and P01308 |
Pubmed |
SVM Score :0.0 |
| There is still uncertainty concerning the joint action of the two established type 1 diabetes susceptibility loci , the HLA class 2 DQB 1 and DRB 1 genes ( IDDM 1 ) and the insulin gene ( INS ) promoter ( IDDM 2 ) . ^^^ |
|
| Interacting proteins: P01920 and P01308 |
Pubmed |
SVM Score :0.0 |
| The genetic component of T1DM is in large part related to genes from the human leukocyte antigen ( HLA ) complex ( IDDM 1 ) ; however , loci from the variable nucleotide tandem repeat ( VNTR ) region of the insulin ( INS ) gene ( IDDM 2 ) and more recently , the cytotoxic T lymphocyte associated protein 4 region ( CTLA 4 , IDDM 12 ) have also been implicated . ^^^ |
|
| Interacting proteins: P01920 and P01308 |
Pubmed |
SVM Score :0.0 |
| We determined the HLA DQB 1 genotypes by denaturing gradient gel electrophoresis ( DGGE ) and / or sequence specific primers ( SSP ) techniques to assess the possible interactions between INS and HLA . ^^^ |
|
| Interacting proteins: P01920 and P01308 |
Pubmed |
SVM Score :0.0 |
| Further subdivision of IDDM patients and matched control subjects according to HLA DQA 1 and HLA DQB 1 genotype or phenotype also failed to show any association between 5 ' INS and HLA class 2 genes in diabetic patients . ^^^ |
|
| Interacting proteins: P01920 and P01308 |
Pubmed |
SVM Score :0.0 |
| The frequency of the 23 HphI INS + / + genotype was higher in diabetic subjects with a low risk HLA DQB 1 genotype than in control subjects ( P = 0 . 05 ) . ^^^ When analysing siblings with a low risk HLA DQB 1 genotype , those with the 23 HphI INS + / + genotype had lower first phase insulin responses ( P < 0 . 02 ) on several occasions than the remaining sibling . ^^^ |
|
| Interacting proteins: P01920 and P01308 |
Pubmed |
SVM Score :0.0 |
| METHODS : We used the sequence specific primer polymerase chain reaction ( PCR SSP ) technique to type HLA DQB 1 alleles , the HLA DRB1alleles DRB1 * 03 and one single nucleotide polymorphism ( SNP ) in the insulin gene ( INS ) . ^^^ |
|
| Interacting proteins: P01920 and P01308 |
Pubmed |
SVM Score :0.0 |
| HLA DQB 1 typing was done using allele specific primers , and INS was typed using the restriction enzyme HphI . ^^^ |
|
| Interacting proteins: P01920 and P01308 |
Pubmed |
SVM Score :0.0 |
| This effect of the INS locus was present in both HLA DQB 1 risk groups . ^^^ |
|
| Interacting proteins: P01920 and P01308 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01920 and P01308 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01920 and P01308 |
Pubmed |
SVM Score :0.0 |
| NA |
|