| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The novel receptor , referred to as the NPY Y 5 receptor , has a transcript of approximately 2 . 6 kilobases with an open reading frame of 1335 base pairs that encodes a 445 amino acid protein . ^^^ |
|
| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Northern blot analysis indicated that the mouse NPY Y 5 receptor mRNA was highly expressed in the brain , but not in the heart , kidney , spleen , lung , liver , skeletal muscle , and testis . ^^^ A genomic DNA clone encoding the mouse NPY Y 5 receptor has also been cloned and used as a probe for fluorescence in situ hybridization analysis . ^^^ The mouse NPY Y 5 receptor gene consists of at least two exons with a 7 . 0 kbp long intronic sequence and is localized in the chromosome 8B3 C 2 region . ^^^ The mouse NPY Y 5 receptor gene can map about 10 kbp upstream of the transcriptional initiation sites of the NPY Y 1 receptor gene with an opposite orientation . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Pharmacological data suggest that NPY ' s stimulatory effect on appetite is transduced by the G protein coupled NPY Y 5 receptor ( Y5R ) . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Stimulation of NPY Y 5 receptor subtypes by a NPY Y 5 selective agonist , rat / human D Trp , was shown to stimulate GTPgamma [ 35S ] binding in the hypothalamus and discrete nuclei of the thalamus . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| We tested the effects of intracerebroventricular injections of human NPY ( hNPY ) and [ D Trp 32 ] NPY , a weak but selective NPY Y 5 receptor agonist , on food intake in lean and obese Zucker rats . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Molecular biology and pharmacology of multiple NPY Y 5 receptor species homologs . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Food intake was measured in freely fed rats following intracerebroventricular administration of neuropeptide Y ( NPY ) and several of its analogues and antagonists to investigate the hypothesis that the NPY Y 5 receptor mediates feeding . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| In LMTK cells transfected with the human NPY Y 5 receptor , CGP 71683A was without intrinsic activity and antagonized NPY induced Ca2+ transients . ^^^ The data demonstrate that the NPY Y 5 receptor subtype plays a role in NPY induced food intake , but also suggest that , with chronic blockade , counterregulatory mechanisms are induced to restore appetite . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| These results suggest either that the Y 1 R in the hypothalamus is not a key molecule in the leptin / NPY pathway , which controls feeding behavior , or that its deficiency is compensated by other receptors , such as NPY Y 5 receptor . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| DESIGN : To investigate the possible role of this receptor in weight regulation , the whole coding region of the NPY Y 5 receptor gene was screened for mutations using temperature gradient gel electrophoresis ( TGGE ) . ^^^ Extended samples of these cohorts ( 160 obese children and adolescents ; mean body mass index ( BMI ) 33 . 5 + / 6 . 4 kg / m2 , 128 underweight subjects ; mean BMI 18 . 4 + / 1 . 0 kg / m2 and 58 patients with AN ; mean BMI 14 . 6 + / 1 . 7 kg / m2 ) were screened to determine the frequencies of a detected mutation and a detected polymorphism in the NPY Y 5 receptor gene . ^^^ RESULTS : The coding region of the NPY Y 5 receptor gene encompasses one exon . ^^^ Both tests for association and linkage to the NPY Y 1 and NPY Y 5 receptor polymorphisms were negative among all cohorts . ^^^ CONCLUSION : The results do not support a major role of the NPY Y 5 receptor gene in the variability of body weight in children and adolescents . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The purpose of this work was to verify the hypothesis that the rabbit ileum is a selective preparation for the NPY Y 5 receptor by using new selective antagonists recently synthesized . ^^^ BIBO 3304 , a selective NPY Y 1 receptor antagonist , and CGP 71683A , a selective NPY Y 5 receptor antagonist , did not affect the response to hPP . ^^^ JCF 109 , another NPY Y 5 receptor antagonist , produced an inhibition of the response to hPP but only at the highest dose tested ( 10 microM ) which also , by itself , produced intrinsic inhibitory effects . 4 . 1229U91 , a non selective ligand for Y 1 , Y 2 , Y 4 and Y 5 receptors with high affinity toward the Y 1 and Y 4 receptor subtypes , produced a concentration dependent transient inhibition of the spontaneous contractions of the rabbit ileum and a dose dependent inhibition of the response to hPP ( apparent pKB : 7 . 2 ) . 5 . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Activation of one of these receptors , the NPY Y 5 receptor , is thought to result in increased food intake , anticonvulsant effects , attenuation of opiate withdrawal , inhibition of neuronal activity , and alteration of renal function . ^^^ Several alternatively spliced human and rat NPY Y 5 receptor cDNAs have been isolated that use different combinations of exons in the 5 ' untranslated region . ^^^ The various human NPY Y 5 receptor cDNAs appear to be differentially expressed in different brain regions . ^^^ The level of human NPY Y 5 receptor expressed transiently in COS 1 cells was significantly influenced by the sequence of the 5 ' untranslated region . ^^^ These results indicate that alternative splicing in the 5 ' untranslated region of the human and rat NPY Y 5 receptor genes occurs in a tissue specific manner and is one mechanism by which cells control the level of NPY Y 5 receptor expression . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y ( NPY ) in the rat is predominantly mediated by the NPY Y 5 receptor subtype . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| To determine whether the NPY Y 5 receptor ( Y5R ) is required for normal control of limbic seizures , we examined hippocampal function and responsiveness to kainic acid induced seizures in Y5R deficient ( Y5R / ) mice . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Activation of the NPY Y 5 receptor regulates both feeding and energy expenditure . ^^^ The present study attempts to further characterize the role of NPY Y 5 receptor subtypes in feeding and energy expenditure regulation . ^^^ These data suggest that the NPY Y 5 receptor subtype not only mediates the feeding response of NPY but also contributes to brown fat temperature and energy expenditure regulation . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NPY Y 5 receptor protein was measured in hippocampal homogenates using a specific polyclonal antibody and quantitative Western blotting . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The increase in GnRH pulse amplitude caused by leptin was totally prevented by coincubation with an anti CART antiserum whereas it was not affected by coincubation with the NPY Y 5 receptor antagonist ( 10 ( 7 ) M ) . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Evidence of NPY Y 5 receptor involvement in food intake elicited by orexin A in sated rats . ^^^ The results show that whereas it was ineffective on its own , a selective NPY Y 5 receptor antagonist , injected icv 15 min . before orexin A significantly suppressed orexin A induced feeding . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Reduced food intake in response to CGP 71683A may be due to mechanisms other than NPY Y 5 receptor blockade . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| To identify the site ( s ) of NPY Y 5 receptor ( Y5R ) mediation of NPY induced feeding , we employed c Fos immunostaining and a selective Y5R antagonist ( Y5R A ) , CGP71683A , in adult male rats . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Aiming to develop a functional assay for the human NPY Y 5 receptor based on adenylyl cyclase activity , HEC 1B cells , in which cAMP synthesis can be efficiently stimulated with forskolin , were selected for the transfection with the pcDNA 3 Y5 FLAG and the pcDEF 3 Y5 vectors . ^^^ The affinities of NPY , NPY derivatives , and rPP ( pNPY > or = p ( Leu31Pro34 ) NPY = p ( 2 36 ) NPY > or = p ( D Trp 32 ) NPY > p ( 13 36 ) NPY > rPP ) were in accordance with the NPY Y 5 receptor subtype . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NPY Y 5 receptor subtype . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Many of the above physiological actions have been at least partially attributed to actions of NPY on the NPY Y 5 receptor subtype . ^^^ We utilized an antibody directed against the NPY Y 5 receptor to characterize the distribution of this receptor in the rat brain . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Several of these arylpyrazoles ( e . g . , 19 and 45 ) displayed high affinity for the human NPY Y 5 receptor ( < 20nM IC ( 50 ) s ) . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A , a potent and selective NPY Y 5 receptor antagonist . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Discovery of potent and selective small molecule NPY Y 5 receptor antagonists . ^^^ The discovery of a new class of sulfonamide NPY Y 5 receptor antagonists is described . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Testing of these compounds for their ability to bind to the human NPY Y 5 receptor revealed separate SAR trends for sulfonamide amides versus sulfonamide ureas versus sulfonamide amines . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Novel sesquiterpenoids from the fermentation of Xylaria persicaria are selective ligands for the NPY Y 5 receptor . ^^^ These compounds are selective for the NPY Y 5 receptor but have only modest affinity . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Selective antagonism of the NPY Y 5 receptor does not have a major effect on feeding in rats . ^^^ Because the orexigenic effects of NPY have been ascribed to actions at the NPY Y 5 receptor , we have determined the role of this receptor in feeding in rats , using a small molecule antagonist of this receptor . ^^^ NPY5RA 972 is a selective and potent ( < 10 nmol / l ) NPY Y 5 receptor antagonist . ^^^ These data indicate that NPY5RA 972 is a potent , selective , orally active , and CNS penetrant antagonist of the NPY Y 5 receptor that prevents feeding driven by activation of this receptor . ^^^ The data obtained with this antagonist indicate that the NPY Y 5 receptor is not a major regulator of feeding in the rat . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Similar neuronal responses were evoked by a NPY Y 5 receptor agonist . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The precise mechanism by which NPY attenuates or blocks photic phase shifts is unclear , but the NPY Y 5 receptor has been implicated in the mediation of this inhibitory effect . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| However , once again , attempts to inhibit the signaling of NPY through the NPY Y 5 receptor produced equivocal effects on food intake . ^^^ Thus , current evidence would suggest that antagonists of NPY acting through the NPY Y 5 receptor subtype will not be useful appetite suppressant / anti obesity agents . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| METHODS : Effects of the novel NPY Y 5 receptor antagonist L 152 , 804 on the onset and maintenance of operant self administration were examined in male C57BL / 6J mice , which were trained to self administer ethanol ( 10 % v / v ) versus water via the sucrose substitution method during 16 hr overnight sessions . ^^^ CONCLUSIONS : These results indicate that blockade NPY Y 5 receptor activity modulates the onset and maintenance of ethanol self administration . ^^^ For this reason , NPY Y 5 receptor antagonists may be useful in medical management of alcohol abuse and alcoholism . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| A potent and selective NPY Y 5 antagonist reduces food intake but not through blockade of the NPY Y 5 receptor . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Blockade of the NPY Y 5 receptor potentiates circadian responses to light : complementary in vivo and in vitro studies . ^^^ This is the first report of a NPY receptor antagonist having such an effect , and indicates that NPY Y 5 receptor antagonists could be clinically useful for potentiating circadian system responses to light . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Both classes of compounds are capable of delivering potent and selective orally and centrally bioavailable NPY Y 5 receptor antagonists . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Additionally , it was shown that NPY Y 5 receptor mediated suppression of oxidative burst in PMA and zymosan stimulated macrophages . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Most of the compounds were found to be potent and selective NPY Y 5 antagonists having nanomolar binding affinities for the NPY Y 5 receptor and showing functional antagonism in the forskolin induced cyclic AMP test . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : We reported previously that neuropeptide Y ( NPY ) induces an atherosclerotic like lesion that is significantly reduced by NPY Y 1 and NPY Y 5 receptor ( R ) inhibitors . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Efforts to find novel appetite suppressant drugs that inhibit the interaction of NPY with either the NPY Y 1 or NPY Y 5 receptor subtypes have proven disappointing . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to determine if NPY Y 5 receptor antagonism reduces ethanol self administration and reinforcement in a rodent genetic animal model of alcoholism . ^^^ These results indicate that blockade of NPY Y 5 receptor activity decreases both voluntary ethanol drinking and ethanol reinforcement in a rodent genetic animal model of alcoholism . ^^^ For this reason , NPY Y 5 receptor antagonists may be useful in medical management of alcohol abuse and alcoholism in the human population . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Among five NPY receptors described , the NPY Y 5 receptor ( Y5R ) is a prime candidate to mediate some of the effects of NPY on energy homeostasis , although its role in physiologically relevant rodent obesity models remains poorly defined . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The non selective Y 1 , Y 2 , Y 4 and Y 5 receptor ligand [ 125I ] PYY and the more selective Y 1 , Y 4 and Y 5 ligand [ 125I ] [ Leu 31 , Pro 34 ] PYY were employed , in conjunction with masking compounds in an attempt to measure any regional changes in the recently cloned NPY Y 5 ' feeding ' receptor . ^^^ Masking [ 125I ] PYY binding to Y 1 receptors using 1 microM BIBP 3226 demonstrated that the reduced NPY receptor density was due to reductions in Y 2 or Y 5 receptor density . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Interestingly , neither [ Pro 34 ] NPY ( 13 36 ) nor the selective Y 5 receptor agonist [ D Trp 32 ] NPY stimulated food intake , whereas both significantly increased plasma ACTH . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Genotype analysis of the neuropeptide Y ( NPY ) Y 1 and NPY Y 5 receptor genes in gonadotropin releasing hormone dependent precocious gonadarche . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Based on the aforementioned , novel hydrazide derivatives were prepared for the purpose of searching new NPY Y 5 receptor antagonists . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Similar to NPY , NPY sulfoxide displayed high affinity binding to each of the cloned Y 1 , Y 2 , Y 4 , and Y 5 receptor subtypes . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| We conclude that NPY lowers blood glucose concentrations via a Y 5 receptor subtype , i . e . a subtype which has also been implicated in stimulation of food intake . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| These data suggest that the Y 5 receptor protein is expressed and translated by a small percentage of hypothalamic neurons and that the effect of NPY on feeding behaviors likely is mediated by more than one class of NPY receptors . ^^^ It also indicates that the Y 5 receptor may be involved in other biological actions induced by NPY . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| An NPY Y 1 and Y 3 receptor agonist , [ Leu 31 , Pro 34 ] NPY and a Y 5 receptor agonist human peptide YY 3 36 ( hPYY 3 36 , both 30 pmol ) , microinjected into the paraventricular nucleus of the hypothalamus ( PVN ) increased the consumption of regular rat chow . ^^^ The stimulatory effect of exogenous NPY is probably mediated through an NPY receptor subtype that is not identical with the Y 1 receptor ( possibly Y 5 receptor ) . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| We now report studies in which phosphothioate end protected antisense oligodeoxynucleotides ( ODNs ) targeted to prepro NPY ( prepro NPY antisense ODNs ) or to the Y 5 receptor ( Y 5 antisense ODNs ) were used to assess the functional importance of this novel receptor subtype in vivo . ^^^ Analysis of the structure of feeding behavior revealed that prepro NPY and Y 5 receptor antisense ODNs reduced food intake by inducing decreases in meal size and meal duration analogous to the orexigenic effects of NPY that are mediated by increases in these parameters . ^^^ Although changes in Y 5 receptor density could not be measured , the results with Y 5 antisense ODNs strongly suggest that this receptor subtype mediates the feeding response to exogenous and endogenous NPY . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Despite the profound reductions of renal blood flow , systemic NPY infusion can cause diuresis and natriuresis ; this is largely independent of pressure natriuresis mechanisms and is possibly mediated by an extrarenal Y 5 receptor . ^^^ |
|
| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| This pharmacological profile suggests that the antiwithdrawal effect of NPY is mediated via the recently cloned Y 5 receptor . ^^^ |
|
| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| In order to trace the aetiology of NPY supersensitivity , we have evaluated ( 1 ) NPY Y 1 and Y 5 receptor ( R ) gene expression in the hypothalamus and ( 2 ) the possibility of alterations in the inhibitory action of leptin , a hormone produced by lipocytes . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Brain neuropeptide Y ( NPY ) subtype 5 ( Y 5 receptor ) mRNA expression in lean ( + / + ) and obese ( ob / ob ) C57Bl / 6 mice was examined using a non radioactive in situ hybridization detection method . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The Y 1 , Y 2 , Y 4 and Y 5 receptor , which belong to the rhodopsin like G protein coupled , 7 transmembrane helix spanning receptors , bind the 36 mer neuromodulator NPY ( neuropeptide Y ) with nanomolar affinity . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Given that mRNA for the cloned Y 5 receptor is apparently restricted to the CNS , Angela Bischoff and Martin Michel discuss the possible existence of additional NPY receptor subtypes with Y 5 like recognition features and their presence in peripheral tissues . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Published reports have suggested that NPY induced feeding is mediated via the Y 1 or the Y 5 receptor subtypes . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| New promising agents are substances that increase the effect of corticotropin releasing factor ( CRF ) or urocortin in the brain ( CRF binding protein ligand inhibitor ) and a neuropeptide Y ( NPY ) Y 5 receptor antagonist . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| A number of neuropeptide Y ( NPY ) receptor subtypes , including the recently cloned Y 5 receptor , have been implicated in the stimulation of food intake . ^^^ In the present study , Y 5 receptor antisense oligodeoxynucleotides ( ODNs ) were used to assess the potential involvement of the Y 5 receptor in the regulation of spontaneous as well as NPY induced food intake . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| However , this binding was bimodal in response to human pancreatic polypeptide and to peptides selective for the Y 2 subtype of the NPY receptor , displaying a large component pharmacologically similar to the brain Y 5 receptor . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Evaluation of hypothalamic NPY Y 1 and Y 5 receptor mRNA by RNase protection assay showed that appetite evoked either by fasting or food restriction increased expression of Y 1 mRNA . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| These results indicate that the food intake evoked by NPY might be mediated by the Y 1 receptor , rather than the Y 5 receptor . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| BIBO 3304 showed low affinity for the human Y 2 receptor , human and rat Y 4 receptor as well as for the human and rat Y 5 receptor ( IC 50 values > 1000 nM ) . 3 . 30 microg BIBO 3304 administered into the paraventricular nucleus inhibited the feeding response induced by 1 microg NPY as well as the hyperphagia induced by a 24 h fast implying a role for Y 1 receptors in NPY mediated feeding . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Hammerhead ribozymes that selectively cleave the NPY Y 1 , Y 4 , and Y 5 receptor full length RNA . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Here , we used an antisense phosphothio oligodeoxynucleotide sequence ( 5 relative to the initiating ATG ) to the Y 5 receptor subtype , which has been suggested to mediate NPY induced feeding . ^^^ The results show that antisense to the Y 5 receptor had no effect on either spontaneous 2 h or NPY , NPY 3 36 , or PP stimulated 2 h food intake . ^^^ The data suggest that the Y 5 receptor has a modulatory role in the maintenance of feeding , but not as the critical receptor to confer for NPY and NPY 3 36 action on food intake . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| To address this issue , we generated a Y 1 receptor deficient ( Y 1 / ) and a Y 5 receptor deficient ( Y 5 / ) mouse line in which we directly compared the orexigenic effects of NPY and its analogs after intracerebroventricular ( icv ) administration . ^^^ The icv NPY induced food intake was remarkably reduced in Y 1 / mice , but was not significantly altered by inactivation of the Y 5 receptor . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The present study evaluated the effect of the neuropeptide Y ( NPY ) Y 1 receptor antagonists BIBO 3304 and SR 120562A and of the Y 5 receptor antagonists JCF 104 , JCF 109 , and CGP 71683A on feeding induced either by NPY or food deprivation . ^^^ The Y 5 receptor antagonists JCF 104 and JCF 109 ( 1 or 10 nmol / rat ) and CGP 71683A ( 10 or 100 nmol / rat ) did not significantly modify the effect of NPY , 0 . 3 nmol / rat . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The stimulatory effects of different NPY receptor agonists [ human PYY 3 36 , porcine NPY 13 36 , human ( D Trp 32 ) NPY , porcine ( Leu 31 Pro 34 ) NPY , human pancreatic polypeptide ( PP ) ] , as well as the absent effects of rat PP were consistent with the involvement of the Y 5 receptor subtype in mediation of NPY effects . ^^^ Incubation with 10 ( 7 ) M of a Y 5 receptor selective antagonist prevented the effect of NPY ( 61 + / 4 vs . 46 + / 2 min ) , whereas leptin and CART effects were not ( 47 + / 3 vs . 46 + / 3 min and 46 + / 3 vs . 46 + / 2 min , respectively ) , suggesting that NPY was not involved in leptin and CART effects . ^^^ NPY causes acceleration of GnRH pulsatility via the Y 5 receptor subtype , which is not involved in leptin effects while the CART is involved in leptin effects on GnRH secretion but not in NPY effects . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| However , by the design of PP / NPY chimera , some analogs have been found that bind not only to the Y 4 , but also to the Y 5 receptor with subnanomolar affinities , and are as potent as NPY at the Y 1 receptor . ^^^ This motif has been shown to induce a 3 ( 10 ) helical turn in the region 28 31 of NPY and is suggested to be the key motif for high Y 5 receptor selectivity . ^^^ The results of feeding experiments in rats treated with the first highly specific Y 5 receptor agonists support the hypothesis that this receptor plays a role in the NPY induced stimulation of food intake . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| In addition , the anorexigenic effects of L 152 , 804 on bPP induced feeding revealed participation of the Y 5 receptor in feeding regulation , while i . c . v . administration of NPY does not appear to significantly contribute to Y 5 stimulated food intake . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Our group has reported on the cloning of a novel rat neuropeptide Y ( NPY ) receptor involved in NPY induced food intake , the Y 5 receptor . ^^^ The distribution of this receptor mRNA is consistent with a role for the Y 5 receptor in food intake and also suggests involvement in other processes mediated by NPY . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Antagonists of the Y 5 receptor ( currently thought to be the NPY ' feeding ' receptor ) have anti obesity effects . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Recent studies suggest that the Y 1 and Y 5 receptor subtypes are intimately involved in NPY induced feeding . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Pharmacological data suggests that the Y 5 receptor subtype contributes to the effects of NPY on appetite , and therefore a Y 5 antagonist might be a useful therapeutic agent for the treatment of obesity . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The IC ( 50 ) values with the Y 1 , Y 2 , and Y 5 receptor subtypes were for NPY 2 . 4 , 3 . 1 , and 3 . 3 nM , for PYY 2 . 3 , 0 . 94 , and 3 . 2 nM , and for phospho PYY 4 . 6 , 2 . 2 , and 5 . 5 nM , respectively . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| To better understand the phylogeny and pharmacology of NPY in non human primates , we have cloned and expressed the NPY Y 1 , Y 2 and Y 5 receptor subtypes from the Rhesus monkey . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The Y 5 receptor has been postulated to be the main receptor mediating NPY induced food intake in rats , based on its pharmacological profile and mRNA distribution . ^^^ Our results show that the Y 5 receptor is well conserved between species ; guinea pig Y 5 displays 96 % overall amino acid sequence identity to human Y 5 , the highest identity reported for any non primate NPY receptor orthologue , regardless of subtype . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NPY was 2 times as potent as the Y 1 , Y 5 receptor agonist , [ Leu ( 31 ) Pro ( 34 ) ] NPY but acted with comparable efficacy . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| These effects of NPY may occur through different receptor subtypes , the Y 2 receptor mediating day time effects and the Y 5 receptor mediating night time effects of NPY . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Our results were as follows . 1 ) Human chromaffin cells constitutively secrete NPY . 2 ) Nicotine elicits a rapid increase in the release of both catecholamines and NPY ; this release of NPY is more sustained than that of catecholamines . 3 ) RT PCR shows expression of Y 1 , Y 2 , Y 4 , and Y 5 receptor mRNA by chromaffin cells ; these receptors are functional , as various receptor specific agonists elicit an increase in intracellular calcium . 4 ) Peptide YY , in contrast to NPY , is not able to stimulate the release of catecholamines . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that NPY , and commonly used Y2R preferring ( NPY ( 13 36 ) ) and Y 5 receptor ( Y5R ) preferring ( [ D Trp ( 32 ) ] NPY and hPP ) peptide agonists , evoke similar levels of inhibition at excitatory CA 3 synapses in hippocampal slices from wild type control mice ( WT ) . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| To evaluate the importance of the NPY Y 1 and Y 5 receptors in the downstream pathways modulated by leptin and controlling energy metabolism as well as the activity of the gonadotrope axis , we studied the effects of leptin administration on food intake and reproductive functions in mice deficient for the expression of either the Y 1 or the Y 5 receptor . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Key motif to gain selectivity at the neuropeptide Y 5 receptor : structure and dynamics of micelle bound [ Ala 31 , Pro 32 ] NPY . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Here we used pharmacologic tools and Y 5 receptor knockout mice to examine the role of Y 5 receptors in mediating the antiexcitatory and antiepileptic actions of NPY in the hippocampal formation . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The enhancing effect of ghrelin on feeding was prevented by the prior administration of the neuropeptide Y Y 5 receptor antagonist ( DTyr ( 2 ) , DThr ( 32 ) ) neuropeptide Y ( NPY , 10 microg ) , but not by the GH RH receptor antagonist MZ 4 71 ( 10 microg ) , or by EP 91073 , a hexarelin analogue that antagonizes the pro erectile effect of EP 80661 ( 10 microg ) , given into the lateral ventricles . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Neuropeptide Y ( NPY ) appears to play a critical role in the integration of appetite and energy expenditure through NPY Y 1 and Y 5 receptor subtypes . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| NPY modulates epinephrine induced leukocytosis via Y 1 and Y 5 receptor activation in vivo : sympathetic co transmission during leukocyte mobilization . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| RESEARCH METHODS AND PROCEDURES : Three month old Osborne Mendel ( OM ) and S5B / Pl rats were fed either a high fat or a low fat diet for 14 days . mRNA for neuropeptide Y ( NPY ) , corticotrophin releasing hormone , NPY Y 1 receptor and Y 5 receptor , and serotonin 2c ( 5 HT2c ) receptors were measured using Northern blotting or ribonuclease protection assays . ^^^ The expression of NPY Y 1 and Y 5 receptor mRNA was significantly higher in the hypothalamus of OM rats compared with S5B / Pl rats . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Both Y 1 and Y 5 receptor agonists nearly doubled food intake compared with that of control animals receiving aCSF , similar to the effect observed for NPY . ^^^ NPY , Y 1 , and Y 5 receptor agonist administration suppressed circulating levels of thyroid hormones ( T 3 and T 4 ) and resulted in inappropriately normal or low TSH levels . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Novel arylpyrazole derivatives were synthesized and evaluated as neuropeptide Y ( NPY ) Y 5 receptor antagonists . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The KCl evoked release of glutamate from hippocampal synaptosomes was inhibited by 1 microM NPY and this effect was insensitive to either BIBP 3226 ( Y 1 receptor antagonist ) or L 152 , 804 ( Y 5 receptor antagonist ) , but was sensitive to BIIE 0246 ( Y 2 receptor antagonist ) . ^^^ We could also pharmacologically dissect the NPY receptors activity by using Y 1 , Y 2 and Y 5 receptor agonists ( [ Leu ( 31 ) , Pro ( 34 ) ] NPY , NPY 13 36 , NPY ( 19 23 ) ( Gly ( 1 ) , Ser ( 3 ) , Gln ( 4 ) , Thr ( 6 ) , Ala ( 31 ) , Aib ( 32 ) , Gln ( 34 ) ) pancreatic polypeptide ( PP ) , respectively ) , and in all the cases we observed that these agonists could inhibited the KCl induced release of glutamate . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Characterization of neuropeptide Y ( NPY ) Y 5 receptor mediated obesity in mice : chronic intracerebroventricular infusion of D Trp ( 34 ) NPY . ^^^ To clarify the role of the neuropeptide Y ( NPY ) Y 5 receptor subtype in energy homeostasis , the effect of the intracerebroventricular infusion of a selective Y 5 agonist , D Trp ( 34 ) NPY , was investigated in C57BL / 6J mice . ^^^ Oral administration of a selective Y 5 antagonist at a dose of 100 mg / kg twice a day completely suppressed all of these D Trp ( 34 ) NPY induced changes , indicating that chronic activation of the Y 5 receptor produces hyperphagia and obesity . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| In VSMCs with low or no NPY responsiveness , pre exposure to beta adrenergic receptor agonist ( isoproterenol ) , forskolin , or dibutyryl cAMP augmented NPY ' s mitogenic effect , while upregulating Y 1 , Y 2 , and Y 5 receptor expression ( isoproterenol only ) . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Exogenous NPY at physiological concentrations also induces Y 5 receptor , stimulates neovascularization , and restores ischemic muscle blood flow and performance . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Y 1 or Y 5 receptor antagonist completely prevented the effect of NPY and reduced angioplasty induced neointima by 50 % . ^^^ CONCLUSIONS : Angioplasty upregulates platelet and vascular NPY systems , which then contribute to neointima formation via Y 1 and Y 5 receptor activation . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Development and characterization of a highly selective neuropeptide Y Y 5 receptor agonist radioligand : [ 125I ] [ hPP 1 17 , Ala 31 , Aib 32 ] NPY . ( 1 ) The existence of multiple classes of neuropeptide Y ( NPY ) receptors ( Y ( 1 ) , Y ( 2 ) , Y ( 4 ) , Y ( 5 ) and y ( 6 ) ) is now well established . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Neuropeptide Y ( NPY ) Y 1 and Y 5 receptor subtypes mediate many of NPY ' s diverse actions in the central nervous system . ^^^ These data provide a detailed and comparative mapping of Y 1 and Y 5 receptor subtypes within cell bodies and nerve fibers in the brain which , together with physiological and electrophysiological studies , provide a better understanding of NPY neural circuitries . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Taken together , these data strongly suggest biological redundancies between Y 1 and Y 5 receptor signaling in the NPY mediated control of food intake . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| In the present work we studied NPY Y 2 and Y 5 receptor ( R ) gene expression in the mouse hypothalamus by using immunohistochemical detection of beta galactosidase ( beta gal ) , a gene reporter molecule for Y2R and Y5R in Y2R knockout ( KO ) and Y5R KO mice , respectively . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The receptor linked internalization of [ 125I ] human neuropeptide Y ( NPY ) in Chinese hamster ovary ( CHO ) cells expressing the guinea pig Y 1 receptors or in human endometrial carcinoma 1B ( Hec 1B ) cells expressing the human Y 5 receptor , as well as the receptor linked internalization of human pancreatic polypeptide ( hPP ) receptor expressed in CHO cells , is selectively inhibited by low molarities of the Li+ cation . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| In the present study , using the new highly selective Y 5 receptor antagonist , CGP71683A , and agonist , [ cPP ] hPP , we show that the Y 5 receptor subtype is centrally involved in NPY induced suppression of spontaneous epileptiform ( interictaform ) bursting in the CA 3 area of rat hippocampal slices . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| K ( + ) evoked Ca ( 2+ ) increases were also inhibited by the selective Y 2 receptor agonists , C 2 NPY and NPY ( 13 36 ) , at concentrations of 1 microM , but not by the selective Y 1 receptor agonist , [ Leu ( 31 ) Pro ( 34 ) ] NPY , selective Y 4 receptor agonist , rPP , or the selective Y 5 receptor agonist , [ d Trp 32 ] NPY . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| We therefore investigated the central effects of porcine NPY , selective Y 1 , Y 2 and Y 5 receptor agonists and a Y 1 receptor antagonist on heart rate ( HR ) and HR variability in freely moving mice using auditory fear conditioning . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Recent evidence has suggested that the Y 1 and Y 5 receptor subtypes may both mediate NPY stimulated feeding . ^^^ NPY and peptide analogs of NPY that selectively activated the NPY Y 1 or Y 5 receptor subtype induced feeding and hyperinsulinemia in satiated Long Evans rats , whereas NPY analogs that selectively activated the NPY Y 2 or Y 4 receptor subtype did not . ^^^ Our data suggest that selective activation of central NPY Y 1 receptor subtype induced hyperinsulinemia independent of food ingestion , whereas the NPY Y 5 receptor induced hyperinsulinemia was dependent on food ingestion . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| In that context , we recently reported on the development of [ 125I ] [ hPP ( 1 17 ) , Ala 31 , Aib 32 ] NPY as Y 5 receptor radioligand . ^^^ Taken together , these data suggest that [ 125I ] [ cPP ( 1 7 ) , NPY ( 19 23 ) , Ala 31 , Aib 32 , Gln 34 ] hPP represents a useful tool to study the unique feature of the Y 5 receptor subtype . . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| In the present study , we addressed this issue by testing the effects of intracerebroventricular ( i . c . v . ) injection of NPY as well as specific receptor agonists for the Y 1 receptor ( [ D His ( 26 ) ] NPY ) , Y 2 receptor ( C 2 NPY ) , and Y 5 receptor ( [ cPP ( 1 7 ) , NPY ( 19 23 ) , Ala ( 31 ) , Aib ( 32 ) , Gln ( 34 ) ] hPP ) in the elevated plus maze and open field tests . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| To be more specific , NPY mediated vascular smooth muscle cell growth , leading to neointima formation , involves Y 1 and Y 1 receptors , while the angiogenic effects of NPY include Y 2 and Y 5 receptor activation . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Neuropeptide Y ( NPY ) has several receptors ; one of them , the neuropeptide Y 5 receptor ( NPY 5 ) seems involved in feeding behavior in mammals . ^^^ It is based upon the cotransfection in human melatonin receptor 1 ( MT 1 ) overexpressing HEK 293 cells of three plasmids encoding melanocortin receptor ( MC 5 ) , neuropeptide Y 5 receptor ( NPY 5 ) and a cyclic AMP response element controlled luciferase . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| This study examines the roles of the NPY Y 1 , Y 2 , and Y 5 receptor ( s ) in energy homeostasis . ^^^ RESEARCH METHODS AND PROCEDURES : We administered intracerebroventricular NPY ( 3 microg / d ) or selective peptide agonists for the Y 1 , Y 2 , and Y 5 receptor subtypes to C57Bl / 6 mice for 6 days by mini osmotic pumps to assess the role of each receptor subtype in NPY induced obesity . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Microinjection of a selective Y 5 receptor agonist , ( Ala ( 31 ) , Aib ( 32 ) ) NPY , into the SCN significantly inhibited light induced phase advances during the late night , but did not induce phase advances during the day . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The Y 5 receptor is expressed in the hypothalamus and has been postulated to be the receptor which mediates the increased food consumption seen following centrally administered NPY . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| N terminal labelled fluorescent BODIPY NPY peptide analogues were tested in Y 1 , Y 2 , Y 4 and Y 5 receptor binding assays performed in rat brain membrane preparations and HEK 293 cells expressing the rat Y 1 , Y 2 , Y 4 and Y 5 receptors . ^^^ These results demonstrate that BODIPY conjugated NPY analogues retain their selectivity , affinity and agonist properties for the Y 1 , Y 2 , Y 4 and Y 5 receptor subtypes , respectively . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| To identify the NPY receptor subtypes involved in the effects of NPY on food intake , we studied the effects of the Y 1 receptor agonist ( Leu 31 , Pro 34 ) NPY ( 4 microg ) , the Y 2 receptor agonist NPY ( 3 36 ) ( 4 microg ) , and the highly specific Y 5 receptor agonist ( cPP ( 1 7 ) , NPY 19 23 , Ala 31 , Aib 32 , Gln 34 ) hPP ( 4 microg ) . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| We evaluated the pharmacological profiles of FMS 586 [ 3 ( 5 , 6 , 7 , 8 tetrahydro 9 isopropyl carbazol 3 yl ) 1 methyl 1 ( 2 pyridin 4 yl ethyl ) urea hydrochloride ] , a novel tetrahydrocarbazole derivative as a neuropeptide Y ( NPY ) Y 5 receptor antagonist . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Injection of Y 5 receptor agonists mimicked the effects of NPY on pineal melatonin , while injection of a Y 2 agonist did not . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Preincubation of cells with NPY up regulated the Y 5 receptor and markedly enhanced endothelial cell migration and proliferation . ^^^ Thus , NPY induced angiogenesis requires participation of Y 1 , Y 2 , and Y 5 receptor subtypes , with the Y 5 receptor acting as an enhancer . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| Receptor binding experiments confirmed NPY binding of the Y 1 receptor in the nanomolar range but gave no evidence for high expression levels of Y 5 receptor subtypes on the cell surface . ^^^ |
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| Interacting proteins: Q15761 and P01303 |
Pubmed |
SVM Score :0.0 |
| The sequence comparisons show that the NPY receptor triplet NPY1R NPY2R NPY5R existed before these large scale duplications . . ^^^ |
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