| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| These studies suggest that cysteamine may change the conformation of the NPY Y 2 receptor and increase its binding activity . . ^^^ |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| The results are compatible with the view that G proteins mediate the central vasopressor actions of NPY ( 13 36 ) and thus probably are involved in NPY Y 2 receptor transduction in cardiovascular areas of the brainstem . . ^^^ |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Preferential increases of [ 125I ] NPY 1 36 binding in the hippocampal formation produced by the NPY Y 2 receptor agonist NPY 13 36 . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| The effect is likely to be mediated via the NPY Y 2 receptor , a pertussis toxin ( PTX ) sensitive G protein , and calcium . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Both synthetic human NPY and NPY ( 18 36 ) , an agonist selective for the NPY Y 2 receptor , stimulated GH and GtH 2 release from the pituitary fragments ; the magnitude of the response to NPY ( 18 36 ) was smaller than that to the whole molecule of NPY . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NPY 13 36 ( a NPY Y 2 receptor agonist ) , however , caused only weak contraction with significantly lower potency . ^^^ |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| It is concluded that NPY inhibits neurotransmission in the rat vas deferens through the activation of a peptide receptor different from the known NPY Y 1 or NPY Y 2 receptor subtypes . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NPY ( EC 50 : 5 . 6 nmol kg 1 ) and NPY fragment 13 36 [ NPY ( 13 36 ) ] ( ED 50 : 4 . 3 nmol kg 1 ) , an NPY Y 2 receptor agonist , dose dependently attenuated [ 125I ] bovine serum albumin extravasation from meningeal vessels when administered 10 min prior to electrical stimulation . [ Leu 31 , Pro 34 ] NPY , an NPY Y 1 and Y 3 receptor agonist , inhibited the response at a higher dose only ( 23 nmol kg 1 ) ( P < 0 . 05 ) . 3 . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| The present study reports the purification of the NPY Y 2 receptor from porcine brain and its biochemical characterization . ^^^ By use of SDS polyacrylamide gel electrophoresis , high performance liquid chromatography gel permeation chromatography , and chemical cross linking studies , the affinity purified brain NPY Y 2 receptor was identified as a monomeric glycoprotein with a molecular mass of 60 kDa . ^^^ Therefore , the purified NPY Y 2 receptor is probably not associated with G proteins , but may have intramolecular free sulfhydryl groups . ^^^ The specific activity of the isolated NPY Y 2 receptor is 15 . 8 nmol / mg of protein . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| We conclude that the depressor effect of intrathecal NPY is mediated primarily by an NPY Y 2 receptor subtype . . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| In contrast , when NPY ( 13 36 ) ( 300 nM ) , a selective NPY Y 2 receptor agonist , was used to block the binding to NPY Y 2 receptors , clonidine ( 1 30 nM ) did not affect the B 0 value and the IC 50 value of NPY ( 1 36 ) when competing for [ 125I ] PYY binding sites , suggesting that the stimulation of alpha 2 receptors can selectively increase the affinity of NYP ( 1 36 ) for the NPY Y 2 receptor . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| These results indicate that NPY Y 1 receptor activation in the Sol leads to the development of a vasodepressor response , which can be counteracted by NPY Y 2 receptor activation in the Sol . ^^^ |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| These effects of NPY were mimicked by [ Leu 31 , Pro 34 ] NPY , a NPY Y 1 receptor agonist whereas [ 13 36 ] NPY , a NPY Y 2 receptor agonist failed to alter the basal , RNS or NE induced increase in perfusion pressure . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Analysis of the predicted amino acid sequence indicates that the polypeptide encoded by this cDNA is 94 % homologous to the human NPY Y 2 receptor . ^^^ In Chinese hamster ovary ( CHO ) cells expressing the mouse NPY Y 2 receptor , an increase in intracellular Ca2+ and inhibition of forskolin induced cAMP accumulation were observed due to stimulation with NPY , NPY ( 13 36 ) and peptide YY , but not with pancreatic polypeptide or [ Leu 31 , Pro 34 ] NPY . ^^^ The fact that the NPY induced increase in intracellular Ca2+ and inhibition of forskolin induced cAMP accumulation were eliminated by pretreatment with pertussis toxin suggests that the NPY Y 2 receptor couples to PTX sensitive G protein ( s ) , probably Gi / Go , in CHO cells . . ^^^ |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Both basal and forskolin stimulated cAMP levels were inhibited by 100 nM NPY and by 100 nM NPY ( 13 36 ) , a selective agonist of the NPY Y 2 receptor subtype . ^^^ |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Using autoradiographic binding methodology with monoiodinated peptide YY together with the agonists neuropeptide Y ( NPY ) and NPY ( 13 36 ) , as well as in situ hybridization with oligonucleotide probes complementary to the NPY Y 2 receptor ( Y 2 R ) mRNA , we have studied whether or not intracerebral prion inoculation affects Y 2 Rs in male CD 1 mice . ^^^ |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Intravenous and intranasal administration of the neuropeptide Y ( NPY ) analogue N acetyl [ Leu 28 , Leu 31 ] NPY 24 36 , a selective NPY Y 2 receptor agonist ( 20 nmol kg 1 ) , significantly attenuated both vasodilator and secretory effects of subsequent parasympathetic nerve stimulation . ^^^ Subsequent pretreatment with the NPY Y 2 receptor agonist N acetyl [ Leu 28 , Leu 31 ] NPY 24 36 reduced the stimulation induced increase in conductance by 30 % . ^^^ Nasal secretion was reduced by 70 % following pretreatment with atropine and a further 30 % by pretreatment with the NPY Y 2 receptor agonist . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Inhibition of sympathetic cholinergic vasodilatation by a selective NPY Y 2 receptor agonist in the gracilis muscle of anaesthetised dogs . ^^^ The results demonstrate a NPY Y 2 receptor mediated inhibition of nerve evoked sympathetic cholinergic vasodilatation but not of sympathetic vasoconstriction . . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| In the present paper , we have used both sympathetic stimulation and the selective NPY Y 2 receptor agonist , N acetyl [ Leu 28 , Leu 31 ] NPY 24 36 , to examine the role of NPY in the inhibition of vagally mediated vasodilatation in the bronchial circulation of the anaesthetised dog . ^^^ Similarly , the NPY Y 2 receptor agonist , N acetyl [ Leu 28 , Leu 31 ] NPY 24 36 , produced a significant ( P < 0 . 05 ) and prolonged ( 15 min ) inhibition of parasympathetically evoked vasodilatation . ^^^ Neither sympathetic stimulation nor the NPY Y 2 receptor agonist could be demonstrated to inhibit this vasodilatation . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| The relevance of the helical structure observed in trifluoroethanol to the structure of this peptide bound to the NPY Y 2 receptor is discussed . . ^^^ |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NPY Y 2 receptor agonist , N acetyl [ Leu 28 , Leu 31 ] NPY 24 36 , reduces renal vasoconstrictor activity in anaesthetised dogs . ^^^ In these experiments we have used the specific NPY Y 2 receptor agonist , N acetyl [ Leu 28 , Leu 31 ] NPY , which lacks local constrictor activity , and have demonstrated inhibition of nerve evoked vasoconstriction in the renal circulation of anaesthetised dogs in a way that suggests an intra renal regional specificity . ^^^ Following the injection of the selective NPY Y 2 receptor agonist , N acetyl [ Leu 28 , Leu 31 ] NPY 24 36 , nerve evoked reductions in renal conductance were reduced by over 45 % . ^^^ |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| The NPY Y 1 receptor agonist , [ Leu 31 , Pro 34 ] NPY and the specific NPY Y 2 receptor agonist N acetyl [ Leu 28 , Leu 31 ] NPY 24 36 both significantly attenuated the vasodilatation and salivary secretion evoked by stimulation of the parasympathetic nerve . ^^^ |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Cloned neuropeptide Y ( NPY ) Y 1 and pancreatic polypeptide Y 4 receptors expressed in Chinese hamster ovary cells show considerable agonist driven internalization , in contrast to the NPY Y 2 receptor . ^^^ |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| This study investigated the effects of BIIE 0246 , a novel neuropeptide Y ( NPY ) Y 2 receptor antagonist , on the inhibition of cholinergic neuroeffector transmission in rat heart and guinea pig trachea and purinergic neuroeffector transmission in guinea pig vas deferens produced by the NPY Y 2 receptor agonist , N acetyl [ Leu 28 , 31 ] NPY 24 36 . 2 . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| The NPY Y 1 receptor agonist [ Leu31Pro34 ] NPY significantly decreased ventilation while the NPY Y 2 receptor agonist N acetyl [ Leu28Leu31 ] NPY 24 36 significantly increased it . ^^^ A similar inverse relationship was seen with respect to blood pressure , with the NPY Y 1 receptor agonist [ Leu31Pro34 ] NPY significantly decreasing blood pressure , while the NPY Y 2 receptor agonist N acetyl [ Leu28Leu31 ] NPY 24 36 significantly increased it . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Attenuation of hypercholesterolemia and hyperglycemia in ob / ob mice by NPY Y 2 receptor ablation . ^^^ It has previously been shown that the NPY Y 2 receptor is required for a full biological response to leptin in the central nervous system . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| However , in the presence of BIIE 0246 , a highly selective non peptide NPY Y 2 receptor antagonist , NPY was unable to increase 4 AP 1 ( to ) density . 4 . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Antibodies directed against the NPY Y 1 receptor revealed immunostaining mainly in the smooth muscle layer of blood vessels whereas antibodies against the NPY Y 2 receptor showed immunostaining in nerve cell bodies . . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| It is possible that the NPY Y 2 receptor activity may partially be linked to presynaptic Ca2+ channels . . ^^^ |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Both the NPY Y 1 receptor agonist [ Leu 31 , Pro 34 ] NPY and NPY Y 2 receptor agonist NPY ( 13 36 ) mimicked the effect of NPY on the number of transported particles . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| The effects of the first selective , non peptide , NPY Y 2 receptor antagonist ( S ) N 2 [ [ 1 [ 2 [ 4 [ ( R , S ) 5 , 11 dihydro 6 ( 6h ) oxodibenz [ b , e ] azepin 11 yl ] 1 piperazinyl ] 2 oxoethyl ] cyclopentyl ] acetyl ] N [ 2 [ 1 , 2 dihydro 3 , 5 ( 4H ) dioxo 1 , 2 diphenyl 3H 1 , 2 , 4 triazol 4 yl ] ethyl ] argininamid ( BIIE 0246 ) were studied on splenic vascular responses evoked in the pig in vivo . ^^^ BIIE 0246 abolished the splenic vasoconstrictor response to the NPY Y 2 receptor agonist N acetyl [ Leu25Leu31 ] NPY ( 24 36 ) , but did not affect the response to the NPY Y 1 receptor agonist [ Leu31Pro34 ] NPY , which in turn was abolished by the selective NPY Y 1 receptor antagonist ( 2R ) 5 ( [ amino ( imino ) methyl ] amino ) 2 [ ( 2 , 2 diphenylacetyl ) amino ] N [ ( IR ) 1 ( 4 hydroxyphenyl ) ethyl ] pentanamide ( H 409 / 22 ) . ^^^ It is concluded that BIIE 0246 exerts selective ( vs the NPY Y 1 receptor ) NPY Y 2 receptor antagonism , and thus represents an interesting tool for classification of NPY receptors , in vivo . ^^^ In addition , evidence for NPY Y 2 receptor mediated vasoconstriction was presented . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Neuropeptide Y ( NPY ) that is released from the intergeniculate leaflet of the lateral geniculate body to the SCN , acts in the SCN to advance circadian phase in the subjective day via the NPY Y 2 receptor . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Involvement of NPY Y 2 receptor subtype in the control of the spontaneous NO / GnRH release at the rat median eminence . ^^^ While several studies implicate NPY Y 1 receptor in the control of GnRH / LH at the time of the preovulatory LH surge , our results also demonstrate the importance of NPY Y 2 receptor in the control of GnRH release via endothelial NO . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Here , we examined the effects of a selective NPY Y 2 receptor antagonist , BIIE 0246 , on operant responding for ethanol in a sweetened solution , or the sweetened solution without ethanol , during 30 min sessions of free choice between the two . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : Retinal NPY and NPY Y 2 receptor expression are altered in the development of oxygen induced retinopathy of the mouse , during both the hyperoxic vasoconstrictive phase and the period of retinal neovascularization . ^^^ Alteration in the production of NPY and the NPY Y 2 receptor may be avenues for potential modification in the development of retinopathy . . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Pretreatment with the NPY Y 2 receptor antagonist BIIE 0246 ( 120 pmol ) in the PVN had no significant effect . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Angiotensin 2 modulates the cardiovascular responses to microinjection of NPY Y 1 and NPY Y 2 receptor agonists into the nucleus tractus solitarii of the rat . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| The NPY Y 2 receptor ( Y2R ) , a putative inhibitory presynaptic receptor , is highly expressed on NPY neurons in the arcuate nucleus , which is accessible to peripheral hormones . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NPY related peptides differently modulated macrophage function , confirming involvement of NPY Y 2 receptor in both potentiation and suppression of oxidative burst in these cells . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| In control mice in the presence of the beta adrenoceptor antagonist propranolol ( 1 mg / kg ) , and 1 micromol / kg BIIE 0426 ( an NPY Y 2 receptor antagonist ) the deltaPI was 57+ / 3 % with a half time to recovery of 2 . 5+ / 0 . 5 min . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| Increased levels of NPY Y 2 receptor and polo like kinase and decreased levels of endothelin receptor type b in L mice are examples of novel gene expression changes not previously identified . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| In other studies on various preparations and in various organs , attenuation of transmitter release has in fact been demonstrated through activation of the NPY Y 2 receptor . ^^^ The significance of the NPY Y 2 receptor was revealed by performing experiments before and after administration of its specific receptor antagonist BIIE 0246 . ^^^ We found that attenuation of the bradycardia during vagal nerve stimulation was dose dependently counteracted by BIIE 0246 and that the tachycardia elicited by sympathetic stimulation remained unaffected after NPY Y 2 receptor blockade . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| The NPY Y 2 receptor has a wide distribution both within the brain and in the periphery . ^^^ In consequence , the administration of both endogenous and exogenous agonists of the NPY Y 2 receptor is likely to cause side effects , particularly regarding pituitary hormone release , as well as on the cardiovascular and gastrointestinal systems . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| We investigated the effects of NPY Y 2 receptor deletion ( Y 2 ( / ) ) in mice on visual attention and response control using the five choice serial reaction time ( 5 CSRT ) task in which accuracy of detection of a brief visual stimulus across five spatial locations may serve as a valid behavioural index of attentional functioning . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| To further our understanding of the genetic elements involved in the regulation of NPY receptor expression , we have cloned and characterized the human gene encoding the type 2 NPY receptor ( Y 2 receptor , HGMW approved symbol NPY2R ) . 2 The transcript spans 9 kb of genomic sequence and is encoded on two exons . ^^^ |
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| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| The sequence comparisons show that the NPY receptor triplet NPY1R NPY2R NPY5R existed before these large scale duplications . . ^^^ |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49146 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
|