| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Competition binding analyses with other peptides such as alpha MSH , NPY and PACAP demonstrated that MCH receptor binding is specific . rANF ( 1 28 ) was found to be a weak competitor of MCH , indicating topological similarities between MCH and rANF ( 1 28 ) when interacting with MCH receptors . . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| These findings were correlated with measurement of the expression in hypothalamus of neuropeptide Y ( NPY ) and melanin concentrating hormone ( MCH ) , two neuropeptides that may be involved in the central regulation of food intake . ^^^ Finally , the induced suppression of food intake and leptin levels occurred despite unchanged or increased hypothalamic expression of the orexigenic neuropeptides NPY and MCH . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Evidence suggesting that galanin ( GAL ) , melanin concentrating hormone ( MCH ) , neurotensin ( NT ) , proopiomelanocortin ( POMC ) and neuropeptide Y ( NPY ) are targets of leptin signaling in the hypothalamus . ^^^ Central administration of leptin ( 5 microg ) for 3 days decreased food intake and body weight gain in association with a decrease in hypothalamic galanin ( GAL ) , melanin concentrating hormone ( MCH ) , proopiomelanocortin ( POMC ) and neuropeptide Y ( NPY ) gene expression and with an increase in neurotensin ( NT ) gene expression . ^^^ In pair fed rats , NPY gene expression was increased and there was no change in either MCH , GAL , POMC or NT gene expression . ^^^ This study identifies GAL , MCH , POMC and NT as non NPY targets of leptin signaling and suggests that leptin ' s action on food intake and body weight is most likely mediated by inhibiting excitatory ( e . g . ^^^ NPY , MCH , GAL , POMC ) and stimulating inhibitory ( e . g . , NT ) signals in the feeding circuitry . . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| POMC mRNA was negatively correlated with both neuropeptide Y ( NPY ) and melanin concentrating hormone ( MCH ) mRNA . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Among these , melanin concentrating hormone ( MCH ) and neuropeptide Y ( NPY ) are potent appetite stimulants , whereas alpha melanocyte stimulating hormone ( alpha MSH ) , neurotensin , and glucagon like peptide ( GLP ) 1 ( 7 36 ) amide have appetite suppressing properties . ^^^ In the current study , we describe the functional interactions between orexigenic ( appetite stimulating : MCH and NPY ) and anorectic ( appetite suppressing : alpha MSH , neurotensin , and GLP 1 ) peptides after intracerebroventricular ( i . c . v . ) administration in the rat . ^^^ The i . c . v . administration of GLP 1 completely prevents the orexigenic effects of both MCH and NPY . ^^^ However , i . c . v . administration of alpha MSH prevents only the orexigenic effect of MCH , as we have previously shown , but does not prevent the effect of NPY on food intake . ^^^ Similarly , i . c . v . administration of neurotensin prevents only the orexigenic effect of MCH , but does not prevent the appetite stimulating effect of NPY . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| In ob / ob mice , leptin deficiency results in increased expression of neuropeptide Y ( NPY ) , agouti related protein ( AGRP ) , and melanin concentrating hormone ( MCH ) , and decreased expression of POMC . ^^^ To define other potential sites of leptin resistance , we used in situ hybridization to evaluate the expression of messenger RNAs ( mRNAs ) encoding a number of peptides , including NPY , AGRP , MCH , and POMC . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Leptin decreases food intake induced by melanin concentrating hormone ( MCH ) , galanin ( GAL ) and neuropeptide Y ( NPY ) in the rat . ^^^ Leptin decreases hypothalamic neuropeptide Y ( NPY ) , melanin concentrating hormone ( MCH ) and galanin ( GAL ) gene expression in rats . ^^^ The purpose of the present study was to test the hypothesis that leptin decreases FI by additionally modulating the action of NPY , MCH or GAL in the hypothalamus . ^^^ Intracerebroventricular ( i . c . v . ) administration of NPY , MCH or GAL induced FI in satiated rats . ^^^ A prior i . c . v . injection of leptin ( 4 microg ) completely prevented the increase of FI either by MCH , GAL or NPY . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Moreover , in both rat and human , MCH and ORX neurons receive innervation from NPY , AgRP , and alpha MSH immunoreactive fibers . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Of these , neuropeptide Y ( NPY ) in the arcuate nucleus and melanin concentrating hormone ( MCH ) and orexins / hypocretins in the lateral hypothalamus have received attention because their expression is increased during fasting and because they promote feeding when administered centrally . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| We compared the orexigenic effect of the orexins administered intracerebroventricular ( ICV ) with other known stimulants of food intake , one strong , neuropeptide Y ( NPY ) , and two weaker , melanin concentrating hormone ( MCH ) and galanin . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| The systems that transport peptides into or out of the CNS can be highly specific , transporting MIF 1 but not Tyr MIF 1 , PACAP 38 but not PACAP 27 , IL 1 but not IL 2 , and leptin but not the smaller ingestive peptides NPY , orexin A , orexin B , CART ( 55 102 [ Met ( O ) ( 67 ) ] ) , MCH , or AgRP ( 83 132 ) . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| The present study investigated the histochemical relationship of CART to the neuropeptides thyrotropin releasing hormone ( TRH ) , melanin concentrating hormone ( MCH ) , orexin / hypocretin and neuropeptide Y ( NPY ) in the hypothalamus . ^^^ These findings further define the position of hypothalamic CART neurons within the hierarchy of brain circuitries regulating energy balance , demonstrating the presence of CART peptide in several cell populations that form putative down stream targets of NPY terminals , including hypophysiotropic TRH neurons and lateral hypothalamic MCH neurons . . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Effect of 2 mercaptoacetate and 2 deoxy D glucose administration on the expression of NPY , AGRP , POMC , MCH and hypocretin / orexin in the rat hypothalamus . ^^^ Using in situ hybridization , the mRNA levels encoding neuropeptide Y ( NPY ) , agouti gene related protein ( AGRP ) , proopiomelanocortin ( POMC ) , melanin concentrating hormone ( MCH ) and hypocretin / orexin ( HC / ORX ) were investigated in the rat arcuate nucleus ( Arc ) and lateral hypothalamic area ( LHA ) 2 h after a single dose of the glucose antimetabolite 2 deoxy D glucose ( 2 DG ; 600 mg / kg ) or of the fatty acid oxidation inhibitor mercaptoacetate ( MA ; 600 mumol / kg ) . ^^^ NPY and AGRP mRNA levels in the Arc were increased by 2 DG but not affected by MA , and MCH mRNA levels in the LHA were increased by both antimetabolites . ^^^ These results suggest that Arc neurons expressing NPY and AGRP are regulated by changes in glucose , but not fatty acid availability , whereas both factors affect MCH neurons in the LHA . . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Leptin receptors have been identified in neuropeptide Y ( NPY ) / lagouti related peptide ( AgRP ) and proopiomelanocortin ( POMC ) / cocaine and amphetamine regulated transcript ( CART ) containing neurons of the ventromedial and ventrolateral arcuate nucleus , respectively , and in melanin concentrating hormone ( MCH ) and hypocretin / orexin containing neurons of the lateral hypothalamus , suggesting that the above mentioned messengers are mediators of leptin ' s action in the hypothalamus . ^^^ Indeed , functional studies show that NPY , AgRP , POMC derived peptides , CART , MCH , and hypocretins / orexins all are important regulators of food intake . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| The current study sought to define the effects of altered adiposity on the expression of genes for neuropeptide Y ( NPY ) , POMC , enkephalin ( ENK ) , and melanin concentrating hormone ( MCH ) . ^^^ Levels of gene expression of NPY and MCH were higher in THIN ewes . ^^^ The appetite stimulators , NPY and MCH , appear to be involved in the metabolic response to altered adiposity , whereas ENK in the periventricular region may be linked to the secretion of GH and possibly LH . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Food intake in the colitic group was assessed after administration of NPY and two other potent orexigenic peptides : melanin concentrating hormone ( MCH ) and hypocretin ( orexin A ) . ^^^ Intraventricular or intrahypothalamic administration of NPY , MCH or hypocretin elicited a feeding response in healthy controls , but not in the colitic group . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| After a 60 h fast , expression of both NPY and MCH mRNA was increased ( by 148 and 33 % , respectively ) while preproorexin expression in the murine LHA did not change . ^^^ Leptin administration to fasted mice blunted the rise in MCH and NPY expression towards control levels . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Effect of LPS administration on the expression of POMC , NPY , galanin , CART and MCH mRNAs in the rat hypothalamus . ^^^ Using in situ hybridization , the levels of mRNAs encoding proopiomelanocortin ( POMC ) , neuropeptide Y ( NPY ) , galanin , melanin concentrating hormone ( MCH ) and cocaine and amphetamine regulated transcript ( CART ) were investigated in the rat hypothalamus after a single intraperitoneal dose ( 125 microg / kg ) of LPS . ^^^ Levels of mRNAs for NPY and galanin in the arcuate nucleus , and for MCH and CART in the zona incerta did not change significantly after LPS treatment . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Melanin concentrating hormone ( MCH ) and NPY are orexigenic peptides localized in the lateral hypothalamic area and arcuate nucleus , respectively . ^^^ Although both NPY and MCH containing fibers innervate areas of the hypothalamus implicated in feeding , the extent to which the regulation of appetite is dependent on interactions between these peptides is unknown . ^^^ Daytime feeding responses to 2 nmol MCH , 1 nmol NPY , or vehicle were investigated in male Sprague Dawley rats previously implanted with intracerebroventricular cannulas . ^^^ NPY and MCH stimulated food intake relative to vehicle ( 4 h intake , 5 . 9 + / 0 . 7 and 3 . 6 + / 0 . 2 g , respectively ; P < 0 . 0001 ) . ^^^ Coadministration of NPY and MCH did not increase food intake above that in response to NPY alone ; however , prior administration of BIBO 3304 resulted in a less marked inhibition of feeding ( P < 0 . 05 , 30 min only ) . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Those agents include neuropeptide Y ( NPY ) , agouti related protein ( AGRP ) , melanocortin receptors ( MC R ) , cocaine amphetamine regulated transcript ( CART ) , pro opiomelanocortin ( POMC ) , orexin A and B ( hypocretins ) , melanin concentrating hormone ( MCH ) and ghrelin ( endogenous ligand of the growth hormone secretagogue receptor ) . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| We conclude that the long lasting hyperphagia induced by AgRP is correlated with and possibly partially mediated by hyperactive OXA neurons in the lateral hypothalamus and CART neurons in the ARC , but not by NPY and MCH neurons . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| The orexigenic neuropeptides that are downregulated by leptin are NPY ( neuropeptide Y ) , MCH ( melanin concentrating hormone ) , orexins , and AGRP ( agouti related peptide ) . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Amongst various neuropeptidergic systems , neuropeptide Y ( NPY ) , hypocretin 1 and melanin concentrating hormone ( MCH ) producing neurons have been shown to play an important role in the regulation of food intake and body weight . ^^^ The icv administration of NPY ( 0 . 118 , 0 . 588 , 1 . 176 nmol ) , hypocretin 1 ( 1 , 3 nmol ) and MCH ( 0 . 42 , 1 . 048 , 2 . 096 nmol ) stimulated food intake in a dose dependent manner . ^^^ Coinjection with 0 . 118 nmol of NPY and hypocretin 1 ( 1 , 3 nmol ) or MCH ( 0 . 42 , 1 . 048 , 2 . 096 nmol ) had no additive effect on food intake as compared to that of NPY alone . ^^^ In contrast , combination of a lower dose of NPY ( 0 . 023 nmol ) or hypocretin 1 ( 0 . 25 nmol ) with lower stimulatory dose ( 0 . 21 , 0 . 42 nmol ) of MCH did not result in further increase in food intake as compared to that of MCH alone . ^^^ Finally , coinjection with of 0 . 023 nmol NPY and 0 . 105 nmol MCH significantly induced food intake as compared to saline control group but not as compared to NPY or MCH treated groups . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| NPY neurons also make contact with orexin and MCH neurons in the LHA , which , in turn , make contacts with GnRH neurons . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Removal of the hypothalamus at the end of the chronic infusion studies allowed measurement of the expression of mRNAs encoding for MCH , neuropeptide Y ( NPY ) , orexin , agouti gene related peptide , cocaine and amphetamine related transcript and neurotensin neuropeptides involved in the control of appetite . ^^^ Chronic intraventricular infusion of MCH activated only NPY mRNA synthesis in Sprague Dawley rats . ^^^ The increase in food intake in response to MCH in Sprague Dawley rats did not appear to be due to the release of NPY since combination studies demonstrated consistently additive effects of the two peptides on food intake at maximum or near maximum doses . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Several neuropeptides with anorexigenic ( POMC , CART , and CRH ) as well as orexigenic ( NPY , AgRP , and MCH ) actions are involved in this complex ( partly redundant ) controlling system . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| We have investigated whether and to what extent neuropeptide Y ( NPY ) , agouti related protein ( AGRP ) , melanin concentrating hormone ( MCH ) , and prepro orexin ( prepro OX ) as well as pro opiomelanocortin ( POMC ) and cocaine and amphetamine regulated transcript ( CART ) mRNA levels are affected in rat hypothalamus . ^^^ Except for prepro OX and compared to fed group , starvation induced an increase in the orexigenic gene expressions that was much more marked in phase 3 ( by 2 . 5 , 8 . 1 , and 13 . 5 fold for MCH , AGRP , and NPY , respectively ) than in phase 2 ( by about 1 . 5 2 . 2 fold as an average ) of fasting . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Hypothalamic levels of NPY , MCH , and prepro orexin mRNA during pregnancy and lactation in the rat : role of prolactin . ^^^ To identify possible factors associated with the increased feeding in these situations , we measured hypothalamic mRNA levels of three orexigenic neuropeptides NPY , MCH , and orexins in nonpregnant , pregnant , and lactating rats by in situ hybridization . ^^^ However , MCH and prepro orexin expression was decreased in both states . 48 or 72 h of fasting in pregnant and lactating rats further elevated NPY mRNA levels and increased the low MCH mRNA content . ^^^ NPY mRNA content was unchanged , but MCH and prepro orexin mRNA levels were significantly decreased . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| While cocaine and amphetamine regulated transcript ( CART ) peptide and melanocortins such as alpha melanocyte stimulating hormone ( alpha MSH ) are anorexigenic and increase energy expenditure , the endogenous melanocortin receptor antagonist agouti gene related protein ( AGRP ) , melanin concentrating hormone ( MCH ) and neuropeptide Y ( NPY ) are orexigenic , anabolic peptides . ^^^ Inhibition was dominant following administration of AGRP , MCH and NPY . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Many kinds of neurons in these areas of the hypothalamus express factors such as melanin concentrating hormone ( MCH ) , neuropeptide Y ( NPY ) , proopiomelanocortin ( POMC ) , orexin ( OX ) and ghrelin , which have been implicated in feeding regulation . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| From Northern blot analysis , NPY , AGRP , and MCH mRNA gene expressions were differentially regulated during prolonged fasting in leptin perfused rats . ^^^ In comparison with fed animals , NPY , AGRP , and MCH mRNA levels in P 3 rats treated with leptin either remained stable or increased slightly . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Orexigenic peptides neuropeptide Y ( NPY ) and MCH showed no direct effect on membrane potential , input resistance , action potential width , or afterhyperpolarization potential , but inhibited voltage dependent calcium channels , indicating that MCH neurons expressed both MCH and NPY receptors . . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| This is associated with a short lived suppression of NPY mRNA , a longer lasting increase in POMC mRNA but no change in MCH mRNA expression . . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Plasma ghrelin and leptin levels reflect peripheral energy balance and regulate hypothalamic neuropeptides such as neuropeptide Y ( NPY ) , pro opiomelanocortin ( POMC ) , cocaine and amphetamine regulated transcript ( CART ) , melanin concentrating hormone ( MCH ) , and orexins . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| It is now established that leptin action in the hypothalamus in regulation of food intake and body weight is mediated by a neural circuitry comprising of orexigenic and anorectic signals , including NPY , MCH , galanin , orexin , GALP , alpha MSH , NT , and CRH . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Decreased food intake correlated with decreased expression of hypothalamic neuropeptide mRNAs for NPY , AgRP , and MCH and an increased expression of neuropeptide mRNAs for alphaMSH ( i . e . , POMC ) and CART . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| AhRR immunoreactivity was present in the nuclei of neurons found in all main hypothalamic groups including NPY , CART , MCH and orexin / hypocretin neurons . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| It should also be noticed that the control of the thermal gradients affects also the neuronal firing rate and hence the transmitter release ( likely above all the release of peptides such as neuropeptide Y ( NPY ) , melanin concentrating hormone ( MCH ) and beta endorphin , e . g . , in the arcuate nucleus representing signals relevant to energy homeostasis ) . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Speakers at the meeting highlighted various targets that hold promise in developing pharmacological treatments for obesity : increasing the activity of satiety factors ( CCK 8 , GPL 1 , ACTH , alphaMSH and 5 HT acting on 5 HT ( 2C ) receptors ) ; inhibiting orexigenic agents ( NPY , MCH , galanin ) ; targeting thermogenesis ( beta ( 3 ) adrenergic agonists and uncoupling proteins ) ; targeting fat absorption ; and targeting neuropeptides . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| In the first experiment , six , castrate male sheep were satiated and received one of four treatments [ saline , 0 . 1 , or 1 . 0 nmol / kg MCH , and NPY ( 0 . 1 nmol / kg ) ] injected ICV over 30s , then infused ICV for 6 h ( approximately 500 microl / h ) . ^^^ In the second experiment , the same sheep were fed to satiety and then randomized to receive one of six treatments [ saline and either 0 . 1 , 1 . 0 or 5 . 0 nmol / kg MCH , 0 . 1 nmol / kg NPY , or MCH+NPY ( 0 . 1 nmol / kg ) ] injected ICV over 30 s . ^^^ All doses of MCH as well as NPY resulted in greater ( P < or=0 . 05 ) food intake than saline . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Administration of JKC 363 , a selective MC4R specific antagonist , coupled with [ Gln ( 6 ) ] alpha MSH ND , specifically reversed the [ Gln ( 6 ) ] alpha MSH ND induced inhibition of food intake , but also reversed the hypothalamic expression levels of neuropeptides such as AGRP , NPY , MCH , and POMC , which suggests [ Gln ( 6 ) ] alpha MSH ND can function as a selective MC4R agonist . . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| The structure and function of many hypothalamic peptides ( Neuropeptide Y ( NPY ) , Melanocortins , Agouti related peptide ( AGRP ) , Cocaine and amphetamine regulated transcript ( CART ) , Melanin concentrating hormone ( MCH ) , Orexins and endocannabinoids ) have been characterised in rodent models . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| NPY , melanin concentrating hormone ( MCH ) and orexin A were infused into the third ventricle ( i3vt ) in a counterbalanced latin square design just prior to rats getting 0 . 1M sucrose solution infused via indwelling intraoral catheters and compared it to intake on bottle tests with access to the same sucrose solution . ^^^ By the final day of the experiment , rats receiving saline consumed as much sucrose as rats receiving NPY , MCH , or orexin A . ^^^ These results are consistent with two conclusions : ( 1 ) NPY , MCH , and orexin A increase both appetitive and consummatory phase ingestive behaviors on initial exposures ; ( 2 ) repeated training interacts with the effects of these orexigenic peptides . . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| Transgenic mice had higher levels of hypothalamic NPY , POMC and MCH mRNA . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To determine whether key appetite regulating neuropeptides such as melanin concentrating hormone ( MCH ) , neuropeptide Y ( NPY ) , and alpha melanocyte stimulating hormone ( alpha MSH ) , which are known to mediate energy balance through centrally mediated pathways , also have direct acute effects on the lipolytic activity of murine adipocytes . ^^^ RESEARCH METHODS AND PROCEDURES : Fully differentiated 3T3 L 1 adipocytes serum starved overnight in Dulbecco ' s modified Eagle medium containing 2 % bovine serum albumin or freshly isolated mouse adipocytes were incubated for up to 2 hours in the absence and presence of 100 nM each of NPY , MCH , alpha MSH , the melanocortin receptor agonist MTII , or isoproterenol as a control . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| METHODS : Receptors of bombesin 3 , cholecystokinin ( CCK ) A , CCK B , glucagon like peptide ( GLP ) 1 , melanin concentrating hormone ( MCH ) 1 , orexin 1 , orexin 2 , neuromedin B , neuropeptide Y ( NPY ) 1 and NPY 5 , neurotensin ( NT ) 1 , NT 2 , NT 3 , and leptin receptor long form mRNA in GT 1 7 cells were detected by reversed transcriptase polymerase chain reaction . ^^^ RESULTS : Receptors of bombesin 3 , CCK B , GLP 1 , MCH 1 , orexin 1 , neuromedin B , NPY 1 , NPY 5 , NT 1 , NT 3 , and leptin receptor long form mRNA were expressed in GT 1 7 cells , of which , receptors of GLP 1 , neuromedin B , NPY 1 , and NT 3 were highly expressed . ^^^ |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P20382 and P01303 |
Pubmed |
SVM Score :0.0 |
| NA |
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