| Interacting proteins: O15130 and P01303 |
Pubmed |
SVM Score :0.0 |
| Among the receptors with the highest amino acid sequence homology to NPFF 1 and NPFF 2 are members of the orexin , NPY , and cholecystokinin families , which have been implicated in feeding . ^^^ |
|
| Interacting proteins: O15130 and P01303 |
Pubmed |
SVM Score :0.0 |
| Agonist and antagonist activities on human NPFF ( 2 ) receptors of the NPY ligands GR 231118 and BIBP 3226 . ^^^ Here , we demonstrate that Neuropeptide Y ( NPY ) ligands , in fact possess significant ability to interact with the human NPFF ( 2 ) receptors . ^^^ NPY Y ( 1 ) antagonist BIBP 3226 and mixed Y ( 1 ) antagonist / Y ( 4 ) agonist GR 231118 are able to displace with low affinity , 50 100 nM , the specific binding on NPFF receptors expressed in CHO cells as well as in rat dorsal spinal cord , an affinity however superior to those determined against Y ( 2 ) , Y ( 4 ) or Y ( 5 ) receptors . ^^^ |
|
| Interacting proteins: O15130 and P01303 |
Pubmed |
SVM Score :0.0 |
| Pharmacological characterization of human NPFF ( 1 ) and NPFF ( 2 ) receptors expressed in CHO cells by using NPY Y ( 1 ) receptor antagonists . ^^^ BIBP 3226 ( ( R ) N ( 2 ) ( diphenylacetyl ) N [ ( 4 hydroxyphenyl ) methyl ] argininamide ) and BIBO 3304 ( ( R ) N ( 2 ) ( diphenylacetyl ) N [ 4 ( aminocarbonylaminomethyl ) benzyl ] argininamide trifluoroacetate ) , two selective neuropeptide Y ( NPY ) Y ( 1 ) receptor antagonists , display relative high affinities for NPFF receptors and exhibit antagonist properties towards hNPFF ( 1 ) receptors . ^^^ |
|
| Interacting proteins: O15130 and P01303 |
Pubmed |
SVM Score :0.0 |
| The NPGPR is most similar to the recently cloned neuropeptide FF ( NPFF ) receptor which lacks exon 1 , but also shows high homology to the orexin and neuropeptide Y ( NPY ) receptor families , two neuropeptides involved in food intake regulation . ^^^ Therefore , we used binding studies to examine the interaction of NPFF , orexin and NPY with the NPGPR . [ 125I ] NPFF was displaced by NPFF with an IC ( 50 ) of 14 . 7 + / 8 . 8 nM , whereas [ 125I ] Orexin B was displaced by Orexin B with an IC ( 50 ) of 415 + / 195 nM . ^^^ |
|
| Interacting proteins: O15130 and P01303 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical distribution patterns of neuropeptide FF ( NPFF ) and neuropeptide tyrosine ( NPY ) were studied in the brain of rats submitted to two different protocols of heroin treatment . ^^^ In drug naive rats , acutely injected heroin significantly depleted NPFF immunoreactive material within the neurons of the nucleus of solitary tract ( NTS ) , significantly decreased the density of NPFF immunoreactive nerve fibers within the median eminence , pituitary stalk , and neurohypophysis , and markedly increased NPY immunoreactive neurons and nerve fibers in the thalamic paraventricular nucleus and bed nucleus of stria terminalis . ^^^ In drug sensitized rats , heroin significantly increased the number and immunostaining intensity of the NPFF immunoreactive neurons within the NTS and induced minor changes in the NPFF immunoreactive nerve fiber network of the median eminence , pituitary stalk , and neurohypophysis and a relatively minor increase in NPY neurons in the thalamic paraventricular nucleus and bed nucleus of stria terminalis . ^^^ |
|
| Interacting proteins: O15130 and P01303 |
Pubmed |
SVM Score :0.0 |
| Collectively , these data suggest that BIBP 3226 , a mixed antagonist of NPY Y 1 and NPFF receptors , shows in vivo antagonistic effects on NPFF receptors . ^^^ |
|