| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.78505058 |
| Less is known about how the glucagon receptor distinguishes between glucagon and GLP 1 . ( 2 ) We analysed chimeric glucagon / GLP 1 peptides for their ability to bind and activate the glucagon receptor , the GLP 1 receptor and chimeric glucagon / GLP 1 receptors . 0.78505058^^^ |
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| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| Substitutions in the NH 2 terminal part of the glucagon molecule with the corresponding GLP 1 residues , as for example in [ Ala 2 , Glu 3 ] glucagon and [ Val 10 , Ser 12 ] glucagon , reduced the binding affinity for the glucagon receptor several hundred fold without increasing the affinity for the GLP 1 receptor . ^^^ In contrast , introduction of GLP 1 residues into the far COOH terminal part of the glucagon molecule , e . g . [ Val 27 , Lys 28 , Gly 29 , Arg 30 ] glucagon , had a minimal effect on recognition of the glucagon receptor , but improved the affinity of the analog for the GLP 1 receptor up to 200 fold . ^^^ Similarly , substitutions in especially the far COOH terminal part of the GLP 1 molecule with the corresponding glucagon residues , e . g . des Arg 30 [ Met 27 , Asn 28 , Thr 29 ] GLP 1 , decreased the affinity for the GLP 1 receptor several hundred fold ( IC 50 = 0 . 4 190 nM ) without increasing the affinity for the glucagon receptor . ^^^ |
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| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| Since the sensitivity of the endocrine pancreas to regulatory hormones can be influenced by their receptor number , we have examined the regulation of glucagon receptor and GLP 1 receptor messenger RNA ( mRNA ) expression in cultured rat pancreatic islets by various factors , including glucose , cAMP , and glucocorticoids . ^^^ |
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| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| Furthermore , regulation of the GLP 1 receptor ( but not the glucagon receptor ) gene in the brain resembled the pattern of region specific gene expression recently defined for the mouse proglucagon gene . ^^^ |
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| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| A series of chimeric receptors in which 4 6 amino acids in the N terminal extracellular domain of the human GLP 1 receptor were replaced with the analogous region of the human glucagon receptor were constructed and expressed in COS 7 cells . ^^^ |
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| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| Glucagon binding was partially displaced by 1 micromol / l des His 1 [ Glu 9 ] glucagon amide , a glucagon receptor antagonist , and by 1 micromol / l GLP 1 . ^^^ |
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| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| Tissue distribution of rat glucagon receptor and GLP 1 receptor gene expression . ^^^ Nuclease protection assay revealed glucagon receptor expression to be highest in liver and kidney , whereas GLP 1 receptor expression was only detected by protection assay in lung , stomach , and large bowel . ^^^ |
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| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| In experimental studies , transient transfection of Chinese hamster ovary cyclic AMP response element ( CRE ) luciferase reporter cells with cDNA for human parathyroid hormone receptor , glucagon receptor , and glucagon like peptide ( GLP 1 ) receptor showed cDNA concentration dependent constitutive activity with parathyroid hormone ( PTH 1 ) and glucagon . ^^^ |
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| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| The specificity of both antagonists was demonstrated by their selective interaction with glucagon receptor signaling in rat hepatocytes and GLP 1 receptor signaling in Chinese hamster lung ( CHL ) fibroblasts . ^^^ |
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| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| Structure function of the glucagon receptor family of G protein coupled receptors : the glucagon , GIP , GLP 1 , and GLP 2 receptors . ^^^ |
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| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| In this study , individual substitution of these four residues of glucagon with the corresponding residues of GLP 1 decreased the affinity and potency at the glucagon receptor relative to glucagon . ^^^ Substitution of distinct segments of the glucagon receptor core domain with the corresponding segments of the GLP 1 receptor rescued the affinity and potency of specific glucagon analogs . ^^^ |
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| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| The actions of glucagon were unaffected by the GLP 1 receptor antagonist exendin ( 9 39 ) but abolished by des His 1 [ Glu 9 ] glucagon amide , a specific blocker of the glucagon receptor . ^^^ |
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| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| The phylogeny of glucagon receptor like genes in fish indicates that a duplication of the glucagon receptor gene occurred on the ancestral fish lineage , and could explain the shared action of glucagon and GLP 1 . ^^^ |
|
| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| On the digestive smooth muscle , exendin ( 9 39 ) behaved as an antagonist for two members of the glucagon receptor family , GLP 1 and glicentin . . ^^^ |
|
| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| Intraocular injections of glucagon or GLP 1 suppressed the proliferation of progenitors in the CMZ , whereas a glucagon receptor antagonist promoted proliferation . ^^^ |
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| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| Targeted mutations were incorporated into the optimal dual receptor binding peptide to identify a peptide with the highly novel property of functioning as both a GLP 1 receptor agonist and a glucagon receptor antagonist . ^^^ |
|
| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01275 and P47871 |
Pubmed |
SVM Score :0.0 |
| NA |
|