| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.54397437 |
| Elucidating the bimolecular interface between parathyroid hormone ( PTH ) and its cognate G protein coupled receptor ( PTHR 1 ) should yield insights into the basis of molecular recognition and the mechanism of ligand mediated intracellular signaling for a system that is critically important in regulating calcium levels in blood . 0.54397437^^^ |
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| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Expression pattern of parathyroid hormone / parathyroid hormone related peptide receptor mRNA in mouse postimplantation embryos indicates involvement in multiple developmental processes . ^^^ In this paper we describe the cloning of the mouse Parathyroid Hormone / Parathyroid Hormone related Peptide Receptor ( PTH / PTHrPR ) cDNA and expression of its mRNA during mouse postimplantation development from day 5 . 5 until day 15 . 5 post coitum ( p . c . ) . ^^^ |
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| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The parathyroid hormone / parathyroid hormone related peptide receptor belongs to a distinct family of G protein coupled receptors , the members of which usually signal through at least two second messenger systems , adenylate cyclase and phospholipase C . ^^^ To search for human diseases that are caused by parathyroid hormone / parathyroid hormone related peptide receptor defects , genomic DNA of patients with pseudohypoparathyroidism type Ib and of patients with Jansen ' s metaphyseal chondrodysplasia was screened for mutations in all coding exons of the receptor gene . ^^^ Inactivating parathyroid hormone / parathyroid hormone related peptide receptor mutations were excluded in patients with pseudohypoparathyroidism type Ib . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The existence of a skeletal resistance to parathyroid hormone in chronic renal failure could be partly as a result of a down regulation of the parathyroid hormone / parathyroid hormone related peptide receptor . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone ( PTH ) activates multiple intracellular effectors , including adenylyl cyclase ( AC ) and phospholipase C ( PLC ) , via a single receptor [ PTH / parathyroid hormone related protein receptor ( PTHR ) ] expressed in bone and kidney . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The major physiological function of parathyroid hormone ( PTH ) is the maintenance of Ca2+ / Pi homeostasis via the parathyroid hormone / parathyroid hormone related protein receptor ( PTHR ) in kidney and bone . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The parathyroid hormone ( PTH ) / PTH related peptide ( PTHrP ) receptor ( PTHR ) functions in skeletal development and mediates an array of other physiological responses modulated by PTH and PTHrP . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone / parathyroid hormone related peptide receptor gene transcripts are expressed from tissue specific and ubiquitous promoters . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Molecular cloning and characterization of a parathyroid hormone / parathyroid hormone related peptide receptor : a member of an ancient family of G protein coupled receptors . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| BsmI polymorphism at the parathyroid hormone receptor locus ( PTHR ) in three populations . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Identification and characterization of parathyroid hormone / parathyroid hormone related peptide receptor in cultured astrocytes . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Using these models from 36 subjects aged 41 80 years , we examined the effects of 17 beta estradiol ( E 2 ) on cell proliferation , osteocalcin ( OC ) production , alkaline phosphatase ( ALP ) and basal and parathyroid hormone ( PTH ) stimulated adenylate cyclase activities , as well as the steady state mRNA levels of ALP , collagen type 1 ( COLL ) , OC , and receptors for E 2 ( ER ) and PTH ( PTHr ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Localization of parathyroid hormone / parathyroid hormone related peptide receptor mRNA in kidney . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Using reverse transcriptase polymerase chain reaction , cells in the four fractions were found to express different levels of transcripts for the parathyroid hormone receptor ( PTHr ) and bone sialoprotein ( BSP ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction ( RT PCR ) phenotyping revealed abundant mRNA for osteocalcin ( OC ) , osteonectin ( ON ) , osteopontin ( OP ) , parathyroid hormone receptor ( PTHr ) , ALP , and procollagen type 1 ( ProI ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Zebrafish express the common parathyroid hormone / parathyroid hormone related peptide receptor ( PTH1R ) and a novel receptor ( PTH3R ) that is preferentially activated by mammalian and fugufish parathyroid hormone related peptide . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The candidate genes studied were the androgen receptor , type 1 collagen A 1 ( COLIA 1 ) , COLIA 2 , COLIIA 1 , vitamin D receptor ( VDR ) , colony stimulating factor 1 , calcium sensing receptor , epidermal growth factor ( EGF ) , estrogen receptor 1 ( ESR 1 ) , fibrillin type 1 , insulin like growth factor 1 , interleukin 1 alpha ( IL 1alpha ) , interleukin 4 ( IL 4 ) , interleukin 6 ( IL 6 ) , interleukin 11 ( IL 11 ) , osteopontin , parathyroid hormone ( PTH ) , PTH related peptide , PTH receptor type 1 ( PTHR 1 ) , transforming growth factor beta 1 , and tumor necrosis factors alpha and beta . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Expression of the human parathyroid hormone ( PTH ) / PTH related peptide receptor ( PTHR ) gene is controlled by three promoters , P 1 P3 . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| A single homozygous nucleotide exchange in exon E 3 of the gene encoding the parathyroid hormone receptor type 1 ( PTHR 1 ) was identified in an infant with Blomstrand chondrodysplasia born to consanguineous parents . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Vitamin D 3 differentially regulates parathyroid hormone / parathyroid hormone related peptide receptor expression in bone and cartilage . ^^^ Transcription of the mouse parathyroid hormone ( PTH ) / PTH related peptide ( PTHrP ) receptor ( PTHR ) gene is controlled by promoters P 1 and P 2 . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Characterization of an element within the rat parathyroid hormone / parathyroid hormone related peptide receptor gene promoter that enhances expression in osteoblastic osteosarcoma 17 / 2 . 8 cells . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| To investigate the molecular basis of osteogenesis in DC , we examined the temporal pattern of gene expression of the proliferation marker histone H 4 , immediate early response genes ( IEGs ) , c fos , c jun , c myc , osteoblast phenotype associated genes , osteocalcin ( OC ) , osteopontin ( OP ) , type 1 collagen ( COL1A1 ) , alkaline phosphatase ( ALP ) , parathyroid hormone receptor ( PTHR ) and matrix modifying enzyme , matrix metalloproteinase 9 ( MMP 9 ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The transcription factors SP 1 and MAZ regulate expression of the parathyroid hormone / parathyroid hormone related peptide receptor gene . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The objectives of this study were : ( 1 ) to characterize the distribution of mRNAs encoding parathyroid hormone ( PTH ) related protein ( PTHrP ) and receptor ( PTHR ) in bovine ovary ; ( 2 ) to characterize the distribution of PTHrP and PTHR polypeptides in bovine ovary ; ( 3 ) to examine the influences of PTHrP ( 1 141 ) treatment during bovine oocyte maturation in vitro on blastocyst development . mRNAs encoding PTHrP and PTHR were detected by in situ hybridization methods in oocytes , and granulosa cells in all follicles from primordial to large antral . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Previously , we showed that by substitution of histidine for residues at the cytoplasmic side of helix 3 ( H 3 ) and helix 6 ( H 6 ) of the parathyroid hormone ( PTH ) receptor ( PTHR ) , a zinc metal ion binding site is engineered that prevents PTH stimulated G ( s ) activation ( Sheikh , S . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| This arrangement is similar to that of the ECD 1 of the parathyroid hormone receptor ( PTHR ) , suggesting a conserved structural motif in the N terminal domain of this family of receptors . . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Identification of determinants of inverse agonism in a constitutively active parathyroid hormone / parathyroid hormone related peptide receptor by photoaffinity cross linking and mutational analysis . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Nuclear localization of the type 1 parathyroid hormone / parathyroid hormone related peptide receptor in MC3T3 E 1 cells : association with serum induced cell proliferation . ^^^ We have recently demonstrated that the receptor for parathyroid hormone ( PTH ) and PTH related peptide ( PTHrP ) , PTHR , can be localized to the nucleus of cells within the liver , kidney , uterus , gut , and ovary of the rat . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| To obtain structural and functional information on the N terminal receptor fragment of human parathyroid hormone receptor 1 ( PTHR 1 ) , the truncated receptor was expressed in the cytosol of Escherichia coli in the form of inclusion bodies . ^^^ These results demonstrate that the extracellular N terminal domain of the parathyroid hormone receptor ( PTHR 1 ) possesses a well defined , stable conformation , which shows a significant ligand binding activity . . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone / parathyroid hormone related peptide receptor mRNA could be detected at low levels in these cells . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Expression level dependent activation of recombinant human parathyroid hormone / parathyroid hormone related peptide receptor : effect of human parathyroid hormone ( 1 34 ) , ( 1 31 ) , and ( 28 48 ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| We show that the parathyroid hormone receptor ( PTHR ) interacts with 14 3 3 and the proteins colocalize within the cell . 14 3 3 interacts with the C terminal tail of the receptor containing a consensus 14 3 3 binding motif , but additional binding sites are also used . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| We report here the involvement of recombinant human IL 11 ( rHuIL 11 ) in osteoblast differentiation in mouse mesenchymal progenitor cells , C3H10T1 / 2 . rHuIL 11 alone increased alkaline phosphatase ( ALP ) activity and upregulated expression levels of osteocalcin ( OC ) , bone sialo protein ( BSP ) , and parathyroid hormone receptor ( PTHR ) mRNA . rHuIL 11 had no effect on expression of type 2 collagen , peroxisome proliferator activated receptor gamma 2 ( PPAR gamma 2 ) , adipocyte fatty acid binding protein P 2 ( aP 2 ) , and myogenic MyoD protein ( MyoD ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Internalization determinants of the parathyroid hormone receptor differentially regulate beta arrestin / receptor association . beta Arrestins have been implicated in regulating internalization of the parathyroid hormone receptor ( PTHR ) , but the structural features in the receptor required for this effect are unknown . ^^^ In the present study performed in HEK 293 cells , we demonstrated that different topological domains of PTHR are implicated in agonist dependent receptor internalization ; truncation of the cytoplasmic tail ( PTHR TR ) , selective mutations of the cytoplasmic tail to remove the sites of parathyroid hormone ( PTH ) stimulated phosphorylation ( PTHR PD ) , and mutations in the third transmembrane helix ( N289A ) or in the third cytoplasmic loop ( K382A ) resulted in a 30 60 % reduction in ( 125 ) 1 PTH related protein internalization . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Of 64 genes known to be associated with bone metabolism , 7 showed weak evidence of linkage by SIBPAL analysis ( p < 0 . 05 ) : cadherin 13 ( CDH 13 ) , bone morphogenetic protein 4 ( BMP 4 ) , proteoglycan 1 ( PRG 1 ) , transforming growth factor beta 3 ( TGFb 3 ) , osteopontin ( OPN ) , parathyroid hormone receptor 1 ( PTHR 1 ) , and insulin like growth factor 1 ( IGF 1 ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Molecular cloning and functional characterization of the canine parathyroid hormone / parathyroid hormone related peptide receptor ( PTH 1 ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The highest levels of parathyroid hormone ( PTH ) / PTH related peptide ( PTHrP ) receptor ( PTHR 1 ) , and Indian hedgehog ( Ihh ) expression were also found in the hypertrophic fractions B 1 and B 2 and not in the prehypertrophic fraction B 3 , as expected from in situ hybridization data on PTHR 1 expression in fetal rodent or chicken growth plates . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The fibroblast growth factor receptor type 3 ( FGFR 3 ) and Indian hedgehog ( IHH ) / parathyroid hormone ( PTH ) / PTH related peptide receptor type 1 ( PTHR 1 ) systems are both essential regulators of endochondral ossification . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The type 1 parathyroid hormone receptor ( PTHR 1 ) binds , with equal affinity , two ligands with distinct biological functions : PTH , the major peptide hormone controlling calcium homeostasis , and the paracrine factor , PTH related peptide ( PTHrP ) , a local regulator of cellular proliferation and differentiation . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| We identified a truncation mutation in the C terminal cytoplasmic tail of the parathyroid hormone ( PTH ) / PTH related peptide ( PTHrP ) type 1 receptor ( PTHR 1 ) gene as the cause of this syndrome . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Expression patterns of parathyroid hormone related peptide ( PTHrP ) and parathyroid hormone receptor type 1 ( PTHR 1 ) during human development are suggestive of roles specific for each gene that are not mediated through the PTHrP / PTHR1 paracrine signaling pathway . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| In rat enterocytes , signaling through the parathyroid hormone ( PTH ) / PTH related peptide receptor type 1 ( PTHR 1 ) includes stimulation of adenylyl cyclase , increases of intracellular calcium , activation of phospholipase C , and the MAP kinase pathway , mechanisms that suffer alterations with ageing . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| In fact , Sp 1 and MAZ bind to the same cis elements in the promoters of the genes for the receptor for serotonin 1A ( HT1Ar ) , endothelial nitric oxide synthase ( eNOS ) , phenylethanolamine N methyltransferase ( PNMT ) , the receptor for parathyroid hormone ( PTHr ) , MAZ and the major late promoter of adenovirus ( AdMLP ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone ( PTH ) , a major regulator of bone metabolism , activates the PTHR 1 receptor on the osteoblast plasma membrane to initiate signaling and induce transcription of primary response genes . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| We used such direct measurements to investigate the activation of the alpha ( 2A ) adrenergic receptor ( alpha ( 2A ) AR ; neurotransmitter ) and the parathyroid hormone receptor ( PTHR ; hormone ) and observed much faster kinetics than expected : approximately 40 ms for the alpha ( 2A ) AR and approximately 1 s for the PTHR . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Chromosomal loci including 1p36 , 2p22 25 , 11q12 13 , parathyroid hormone receptor type 1 ( PTHR 1 ) , interleukin 6 ( IL 6 ) , interleukin 1 alpha ( IL 1alpha ) and type 2 collagen A1 / vitamin D receptor ( COL11A1 / VDR ) have been linked or shown suggestive linkage with BMD in other populations . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The aim of the present study was to analyze the functional importance for the parathyroid hormone ( PTH ) / PTH related peptide ( PTHrP ) receptor ( PTHR 1 ) gene P 2 promoter activity of the putative proximal Myc associated zinc finger protein ( MAZ ) site localized at position bp 45 to 39 bp , taking advantage of a G / A mutation identified at position 40 in the human sequence . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| These eight genes are apolipoprotein E ( APOE ) , type 1 collagen alpha 1 ( COL1A1 ) , estrogen receptor alpha ( ER alpha ) , leptin receptor ( LEPR ) , parathyroid hormone ( PTH ) / PTH related peptide receptor type 1 ( PTHR 1 ) , transforming growth factor beta 1 ( TGF beta 1 ) , uncoupling protein 3 ( UCP 3 ) , and vitamin D ( 1 , 25 dihydroxyvitamin D 3 ) receptor ( VDR ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Recently , an activating mutation in the parathyroid hormone receptor type 1 ( PTHR 1 ) gene , c . 448C > T ( p . ^^^ |
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| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Current antagonists for the parathyroid hormone ( PTH ) / PTH related protein ( PTHrP ) receptor ( PTHR ) are N terminally truncated or N terminally modified analogs of PTH ( 1 34 ) or PTHrP ( 1 34 ) and are thought to bind predominantly to the N terminal extracellular ( N ) domain of the receptor . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Collagen type 1 alpha 2 ( COL1A2 ) and parathyroid hormone ( PTH ) / PTH related peptide receptor ( PTHR 1 ) are two prominent candidate genes for bone mineral density ( BMD ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Indian Hedgehog ( IHH ) / parathyroid hormone related peptide ( PTHrP ) signalling , an important pathway in chondrocyte proliferation and differentiation within the normal growth plate , was studied by immunohistochemical analysis of the expression of PTHrP , PTHR 1 , Bcl 2 , p 21 , cyclin D 1 , and cyclin E . ^^^ |
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| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Our empirical data demonstrated that two rare haplotypes of the parathyroid hormone ( PTH ) / PTH related peptide receptor type 1 and vitamin D receptor genes ( PTHR 1 and VDR ) with frequencies of 1 . 1 % and 2 . 9 % , respectively , had significant effects on osteoporosis phenotypes ( p = 4 . 2 10 10 ( 6 ) and p = 1 . 6 10 10 ( 4 ) , respectively ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Here , the subdomain of the CLR that associates with RAMP 1 has been identified in chimeras between the CLR and the parathyroid hormone ( PTH ) receptor 1 ( PTHR ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| A quantitative PCR ( Q PCR ) method has been established to measure the mRNA expression levels of parathyroid hormone related protein ( PTHrP ) , parathyroid hormone receptor type 1 ( PTHR 1 ) , and calcium sensing receptor ( CaSR ) in sea bream ( Sparus aurata ) , using the housekeeping gene , beta actin , as endogenous control . ^^^ |
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| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| To demonstrate this approach , a ZFP TF activator of the human parathyroid hormone receptor 1 ( PTHR 1 ) gene was identified and introduced into HEK 293 cells ( negative for PTHR 1 ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| In the present study , we have searched for proteins that interact with the C terminus of PTH ( parathyroid hormone ) / PTH related protein receptor ( PTHR ) by using the yeast two hybrid system , and identified a cytoskeletal protein 4 . 1G ( generaltype 4 . 1 protein ) as an interactant with the C terminus . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Non ( 1 84 ) parathyroid hormone ( PTH ) fragments are large circulating carboxyl terminal ( C ) fragments with a partially preserved amino terminal ( N ) structure . hPTH ( 7 84 ) , a synthetic surrogate , has been demonstrated to exert biologic effects in vivo and in vitro which are opposite to those of hPTH ( 1 34 ) on the PTH / PTHrP type 1 receptor through a C PTH receptor . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone ( PTH ) and its related receptor ( PTHR ) are essential regulators of calcium homeostasis and bone physiology . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| We tested the relationship of the ApaI , Eco31I , BstBI , and ( AAAG ) n polymorphisms in the vitamin D receptor ( VDR ) , collagen type 1 alpha 1 ( COL1A1 ) , parathyroid hormone ( PTH ) , and parathyroid hormone ( PTH ) / PTH related peptide receptor ( PTHR 1 ) genes with variations in bone size ( BS ) and height . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Expression of PTHR 1 ( Parathyroid Hormone Receptor 1 ) transcripts was restricted to a narrow zone of prehypertrophic chondrocytes . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The parathyroid hormone type 1 receptor ( PTHR 1 ) mediates the actions of parathyroid hormone ( PTH ) and parathyroid hormone related protein ( PTHRP ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Parathyroid hormone ( PTH ) regulates osteoblast function by binding to the PTH receptor 1 ( PTHR 1 ) to activate downstream signaling to induce expression of primary response genes ( PRGs ) , which affect various aspects of the osteoblast phenotype . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Normal and Nx ( 3 / 4 nephrectomy ) rats were divided into two groups : ( 1 ) rats with intact parathyroid glands ( IPTG ) and ( 2 ) parathyroidectomized rats in which PTH was replaced ( PTHR ) by the continuous infusion of rat 1 34 PTH , 0 . 022 microgram / hr / 100 g body wt , using a miniosmotic Alzet pump . ^^^ Even in N rats on a HPD , high PTH levels ( 67 + / 8 pg / ml in the N IPTG HPD group ) were required to maintain normal serum calcitriol levels ( 69 + / 4 vs . 56 + / 6 pg / ml in Nx IPTG HPD and Nx PTHR HPD groups , respectively ; P < 0 . 05 ) . ^^^ In contrast , serum calcitriol levels were low in the Nx PTHR HPD group ( 52 + / 4 pg / ml , P < 0 . 05 ) , which were deprived of the adaptative increase in endogenous PTH production . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The kidney is the major site of expression of the PTH / PTH related peptide receptor ( PTHR ) gene . ^^^ Immunohistochemical and immunoelectron microscopic analysis showed that PTHR protein is expressed on both basolateral and luminal membranes of proximal tubular epithelial cells , strongly suggesting a bipolar mode of action of PTH . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Expression of the PTH / PTH related peptide ( PTHrP ) receptor ( PTHR ) in the mouse is controlled by at least two promoters . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Previous studies of PTHR signaling and function employed mainly rodent or other cell lines that express endogenous PTHRs and , possibly , alternate species of PTH receptors . ^^^ We conclude that amino truncated PTH analogs reported to activate PKC can not directly activate phosphatidylinositol specific PLC via the human or rat PTHR and therefore that PTH receptors may access alternate , PLC independent pathways of PKC activation in some target cells . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| METHODS : We examined the amounts of PTHrP and PTH / PTHrP receptor ( PTHR ) mRNA in the mouse kidney developmental process by reverse transcription polymerase chain reaction , and investigated which cells produce PTHrP and PTHR in vivo by in situ hybridization . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The PTH / PTH related peptide ( PTHrP ) receptor ( PTHR ) is required for normal skeletal development , and a wide array of physiological responses mediated by PTH and PTHrP . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| To address the question of whether there might be functional mutual regulation of T ( 3 ) receptors ( TR ) and PTH / PTHrP receptors ( PTHR ) , we studied their expression and receptor mediated intracellular effects in rat osteoblastic osteosarcoma ( ROS ) 17 / 2 . 8 cells . ^^^ T ( 3 ) pretreatment increased both PTH induced cyclic AMP response element binding protein ( CREB ) phosphorylation and PTH induced intracellular calcium transients , and further decreased PTH induced down regulation of alkaline phosphatase activity , suggesting that there are functional consequences of the PTHR up regulation . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Parathyoid hormone ( PTH ) and PTH related peptide ( PTHrP ) signal through a common PTH / PTHrP receptor ( PTHR 1 ) . ^^^ We also compare the conserved and distinct aspects of PTHR 1 gene regulation in the two systems and their bearing on signaling by PTH and PTHrP . . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Because of the selective resistance toward PTH , inactivating mutations in its receptor , the PTH / PTH related peptide receptor ( PTHR 1 ) , were thought to be responsible for PHP 1b . ^^^ In conclusion , despite the selective resistance toward PTH in the kidney , which mainly uses the PTHR 1 P3 promoter , PHP 1b in eight cases is not associated with structural abnormalities in this promoter . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Recent studies in transgenic mice have demonstrated that PTH related protein ( PTHrP ) , signaling through the type 1 PTH / PTHrP receptor ( PTHR 1 ) , regulates endochondral bone development and epithelial mesenchymal interactions during the formation of the mammary glands and teeth . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| PTHrP and PTH act via a common membrane receptor ( PTHR ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| In order to examine the cellular abnormalities in renal bone disease we have performed a series of in situ hybridization studies to examine renal bone cell expression of genes for PTH receptor ( PTHR 1 ) , transforming growth factor beta ( TGF beta ) and insulin growth factor 1 ( IGF 1 ) . ^^^ PTHR 1 mRNA was expressed predominantly by osteoblasts , but also by resorbing osteoclasts , suggesting that these cells may be stimulated directly by PTH . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The present studies were carried out to evaluate the mechanisms by which PTH / PTHrP receptor ( PTHR ) activation influences cell viability . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The localization of PTH / PTH related peptide ( PTHrP ) receptor ( PTHR ) has traditionally been performed by autoradiography . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Both PTH and PTHrP bind to the common type 1 PTH / PTHrP receptor ( PTHR ) , thereby activating phospholipase C and adenylate cyclase through various G proteins , in bone and renal cells . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The recovery of PTH receptor ( PTHR ) function after acute homologous receptor desensitization and down regulation in bone and kidney cells has been attributed to receptor recycling . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| To evaluate the potential role of endogenous PTHrP in the control of renal hemodynamics , we performed clearance measurements in transgenic ( TG ) mice in which the SMP 8 alpha actin promoter was used to drive overexpression of the PTH / PTHrP type 1 receptor in smooth muscle . ^^^ Our findings indicate that smooth muscle specific overexpression of the PTH / PTHrP type 1 receptor resulted in augmentation of the vasodilatory response to SVE and attenuation of the vasoconstrictor response to ANG 2 . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| In attempts to seek cellular proteins that mediate these processes of PTH / PTH related protein receptor ( PTHR ) , one of the class B GPCRs , we have found that Tctex 1 , a 14kDa light chain of cytoplasmic dynein motor complex , interacts with the COOH terminal tail of the receptor . ^^^ A GFP fused mutant PTHR impaired in binding to Tctex 1 expressed in MDCK cells showed a decreased rate of internalization in response to PTH compared to that of the wild type . . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| We compared skeletal morphology , mineralization characteristics , and gene expression in growth plates of fetal mice that lack parathyroids and PTH ( Hoxa 3 null ) with the effects of loss of PTHrP ( Pthrp null ) , loss of PTH / PTHrP receptor ( Pthr 1 null ) , and loss of both PTH and PTHrP ( Hoxa 3 null 10 Pthrp null ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| FGF 2 ( 0 . 1 nM ) increased the mRNAs for type 1 collagen : osteocalcin , runt domain / core binding factor , PTH / PTHR receptor , and insulin like growth factor 1 ( IGF 1 ) at 14 and 21 days . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The PTH / PTHrP receptor ( PTHR 1 ) plays an essential role in skeletal development and mediates many other functions of PTH and PTHrP . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Messenger ( m ) RNA for PTHrP , Ihh , PTH receptor ( PTHR ; a receptor for PTHrP ) , patched ( Ptc ; a receptor for Ihh ) , bone morphogenetic protein ( BMP ) 6 , and collagen type 10 ( COL 10 ; a marker for mature chondrocyte ) was localized in the tissue sections by performing in situ hybridization . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| We examined here the role of second messenger dependent kinases and beta arrestins in short term regulation of the PTH receptor ( PTHR ) signaling . ^^^ The inhibition of protein kinase C ( PKC ) in COS 7 cells transiently expressing PTHR , led to an approximately 2 fold increase in PTH stimulated inositol phosphate ( IP ) and cAMP production . ^^^ PKC inhibition was associated with a decrease in agonist stimulated PTHR phosphorylation and internalization without blocking PTH dependent mobilization of beta arrestin 2 to the plasma membrane . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Ligand binding studies of piscine 125I ( 1 35 ( tyr ) ) PTHrP to the membrane fraction of isolated sea bream scales revealed the existence of a single PTH receptor ( PTHR ) type . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| We have characterised PTH receptors ( PTHR ) in piscine enterocytes and established , by using amino terminal PTHrP peptides , the amino acid residues important for receptor activation and for stabilising the ligand / receptor complex . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Putting these and other facts together produces a possible picture of an exogenously applied adenylyl cyclase activating PTH pinch hitting for the missing PTHrP and restoring normal keratinocyte proliferative activity epidermal structure by stimulating dermal fibroblasts which do have the conventional adenylyl cyclase linked PTHR 1 and in response directly or indirectly restore the overlying basal keratinocytes ' Notch Notch ligand terminal differentiation driving mechanism and consequently a normal epidermal structure . . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Several markers of osteoblast activity , including c fos , RANKL , PHEX , and PTHR 1 , were consistently upregulated by PTH in both skeletal sites . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| These results , together with the expression of mRNA for PTHrP and for PTH receptor ( PTHR ) type 1 and PTHR type 3 receptors in sea bream interrenal tissue , suggest a specific paracrine or autocrine steroidogenic action of PTHrP mediated by the PTHRs . . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| This in turn points to a probable high affinity interaction with the C PTH receptor , as observed previously with [ Tyr ( 34 ) ] hPTH ( 19 84 ) in various cell lines and in mouse osteocytes with PTH / PTHrP type 1 receptor ablation . . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Several causes have been postulated to modify the hormone response in intestinal cells with ageing , among them , alterations of PTH receptor ( PTHR 1 ) binding sites , reduced expression of G proteins and hormone signal transduction changes . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| It is widely believed that the main mechanism of hypocalcemia in chronic renal failure is the blunted skeletal response to PTH , probably due to appearance of PTH 7 84 or PTHR down regulation in bone . ^^^ We indicated that the down regulation of renal PTHR mRNA could contribute to the development of the skeletal resistance for PTH in CRF rats . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| They stimulate osteoblast accumulation and bone formation in three ways via signals from the type 1 PTH / PTH related protein ( PTHR 1 ) receptors on proliferatively inactive preosteoblasts , osteoblasts , osteocytes and bone lining cells . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| These effects are opposite to those of human PTH ( 1 84 ) on the PTH / PTHrP type 1 receptor . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| PTH induces osteoblastic gene expression through PTHR 1 , a heptahelical receptor that triggers cyclic adenosine monophosphate ( cAMP ) protein kinase A ( PKA ) , protein kinase C ( PKC ) , and calcium signaling . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Mechanisms of ligand binding to the PTH / PTHrP receptor ( PTHR ) were explored using PTH fragment analogs as radioligands in binding assays . ^^^ In particular , the modified amino terminal fragment analog , ( 125 ) 1 [ Aib ( 1 , 3 ) , Nle 8 , Gln 10 , homoarginine 11 , Ala 12 , Trp 14 , Tyr 15 ] rPTH ( 1 15 ) NH 2 , ( 125 ) 1 [ Aib ( 1 , 3 ) , M ] PTH ( 1 15 ) , was used as a radioligand that we hypothesized to bind solely to the juxtamembrane ( J ) portion of the PTHR containing the extracellular loops and transmembrane helices . ^^^ We also employed ( 125 ) 1 PTH ( 1 34 ) as a radioligand that binds to both the amino terminal extracellular ( N ) and J domains of the PTHR . ^^^ We found that the binding of ( 125 ) 1 [ Aib ( 1 , 3 ) , M ] PTH ( 1 15 ) to the wild type PTHR was strongly ( approximately 90 % ) inhibited by guanosine 5 ' O ( 3 thio ) triphosphate ( GTPgammaS ) , whereas the binding of ( 125 ) 1 PTH ( 1 34 ) was only mildly ( approximately 25 % ) inhibited by GTPgammaS . ^^^ Of these two radioligands , only ( 125 ) 1 [ Aib ( 1 , 3 ) , M ] PTH ( 1 15 ) bound to PTHR delNt , which lacks most of the receptor ' s N domain , and again this binding was strongly inhibited by GTPgammaS . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| With the advent of advances in chemical and molecular biology , the structure of PTH and its principal receptor ( PTHrP receptor [ PTHR 1 ] ) were established . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| The aim of our study was to examine whether C terminal PTH 7 84 regulates secretion of PTH 1 84 and affects the expression of genes of relevance for parathyroid function , PTH , calcium sensing receptor ( CaR ) , PTH type 1 receptor ( PTHR 1 ) , and PTH related peptide ( PTHrP ) genes in rat parathyroid glands . ^^^ The expression of PTH , CaR , PTHR 1 , and PTHrP genes in the rat parathyroid glands was not affected by PTH 7 84 . ^^^ These effects of PTH 7 84 on PTH 1 84 secretion and on plasma Ca2+ levels were not associated with significant changes in PTH , PTHR 1 , CaR , and PTHrP gene expressions in the rat parathyroid glands . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| Synthetic C PTH fragments do not bind to the PTH / PTHrP type 1 receptor and are not implicated in the classical biological effect of PTH ( 1 84 ) . ^^^ |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and Q03431 |
Pubmed |
SVM Score :0.0 |
| NA |
|