| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.53956504 |
| The type 1 parathyroid hormone receptor ( PTHR 1 ) binds , with equal affinity , two ligands with distinct biological functions : PTH , the major peptide hormone controlling calcium homeostasis , and the paracrine factor , PTH related peptide ( PTHrP ) , a local regulator of cellular proliferation and differentiation . 0.53956504^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Autoantibodies to parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Solubilization of a parathyroid hormone receptor from bovine kidney cortex plasma membranes . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| A new technic to evaluate the sensitivity of the renal parathyroid hormone receptor in man ] . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| A series of clinical studies suggest that the primary defect underlying pseudohypoparathyroidism is an abnormality of the parathyroid hormone receptor adenylate cyclase complex of the renal cortical cell plasma membrane . ^^^ These results indicate that the defect in the parathyroid hormone receptor adenylate cyclase complex of the renal cell membranes , in our patient with pseudohypoparathyroidism , is an abnormal nucleotide receptor site of decreased activity . ^^^ Such a defect may result in partial uncoupling of the parathyroid hormone receptor and adenylate cyclase , rendering the organ refractory to hormonal stimulation . . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Effect of transforming growth factor beta on parathyroid hormone receptor binding and cAMP formation in rat osteosarcoma cells . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| This dual coupling is also a characteristic of the parathyroid hormone receptor , which has significant homology in amino acid sequence with the CT receptor . . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| D reduces parathyroid hormone receptor number in ROS 17 / 2 . 8 cells and prevents the glucocorticoid induced increase in these receptors : relationship to adenylate cyclase activation . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Application to fluorescence activated cell sorting of parathyroid hormone receptor bearing cells . [ Nle 8 , 18 , Tyr 34 ] bPTH ( 1 34 ) amide ( NlePTH ) was biotinylated using sulfosuccinimidyl 6 ( biotinamido ) hexanoate , in dimethyl sulfoxide , and the multiple resulting peptides peaks were separated by reverse phase high performance liquid chromatography . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Biochemical and morphological characterization of parathyroid hormone receptor binding to the rat osteosarcoma cell line UMR 106 . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Nonetheless , both peptides activate the parathyroid hormone receptor to produce hypercalcemia . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| These characteristics are shared by the parathyroid hormone receptor agonists associated with humoral hypercalcemia of malignancy , which suggests that normal human keratinocytes may produce a factor related to that produced by malignant tumors associated with humoral hypercalcemia of malignancy . . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Biotinylated parathyroid hormone as a probe for the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The canine renal parathyroid hormone receptor is a glycoprotein : characterization and partial purification . ^^^ Covalent labeling of the canine renal parathyroid hormone receptor with [ 125I ] bPTH ( 1 34 ) reveals several major binding components that display characteristics consistent with a physiologically relevant adenylate cyclase linked receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Inhibition of in vitro bone resorption by a parathyroid hormone receptor antagonist in the canine adenocarcinoma model of humoral hypercalcemia of malignancy . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor activation is restored by parathyroidectomy , beta adrenergic agonists no longer desensitize in older animals , and muscarinic receptors from senescent rats pharmacologically mimic desensitized receptors . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Structural properties of the renal parathyroid hormone receptor : hydrodynamic analysis and protease sensitivity . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor in human placental syncytiotrophoblast brush border and basal plasma membranes . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| A factor produced by cultured rat Leydig tumor ( Rice 500 ) cells associated with humoral hypercalcemia stimulates adenosine 3 ' , 5 ' monophosphate production via the parathyroid hormone receptor in human skin fibroblasts . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Evaluation of renal parathyroid hormone receptor function in myotonic dystrophy . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation of the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Covalent labeling of a high affinity , guanyl nucleotide sensitive parathyroid hormone receptor in canine renal cortex . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The AC stimulating activity of CAC 8 appeared to bind to the parathyroid hormone receptor of ROS , UMR , and OK cells since addition of the parathyroid hormone receptor antagonist , [ 8 , 18norleucine , 34tyrosine ] BPTH ( 3 34 ) amide , inhibited CAC 8 mediated cyclic adenosine 5 ' monophosphate production and alone did not stimulate AC activity . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor in bovine kidney cortex plasma membranes . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| These studies demonstrate that it is possible to alter the amino terminus of parathyroid hormone analogues without causing a dramatic decline in affinity for the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Studies were undertaken to identify and characterize components of the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor in intact embryonic chicken bone : characterization and cellular localization . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Coupling of the canine renal parathyroid hormone receptor to adenylate cyclase : modulation by guanyl nucleotides and N ethylmaleimide . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| In contrast , OP 1 treatment stimulated phenotypic differentiation in ROS 17 / 2 . 8 cells , as indicated by enhanced 1 ) alkaline phosphatase activity ( 4 fold ) ; 2 ) alkaline phosphatase mRNA ( 5 fold ) ; 3 ) parathyroid hormone receptor mRNA ( 2 fold ) , and 4 ) parathyroid hormone stimulated adenosine 3 ' , 5 ' cyclic monophosphate accumulation ( 2 fold ) . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| We report the in vivo whole body distribution and blood plasma pharmacokinetics of the parathyroid hormone receptor antagonist [ Nle 8 , 18 , D Trp 12 , monoiodinated Tyr 34 ] bPTH ( 7 34 ) amide to determine parameters that are likely to affect its administration regimen . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Heparin insensitive calcium release from intracellular stores triggered by the recombinant human parathyroid hormone receptor . 1 . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Coordinate regulation of rat renal parathyroid hormone receptor mRNA and Na Pi cotransporter mRNA and protein . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Identification and functional expression of a receptor selectively recognizing parathyroid hormone , the PTH 2 receptor . ^^^ We have identified a G protein coupled receptor specifically activated by parathyroid hormone , which we refer to as the PTH 2 receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Determinants of [ Arg 2 ] PTH ( 1 34 ) binding and signaling in the transmembrane region of the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Intron positions were similar to the positions of introns in growth hormone releasing hormone receptor and parathyroid hormone receptor , two receptors belonging to the same receptor family as the glucagon receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| A C terminally truncated human parathyroid hormone receptor is functional and activates multiple G proteins . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| BsmI polymorphism at the parathyroid hormone receptor locus ( PTHR ) in three populations . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The osteogenic differentiation potential of C3H10T1 / 2 cells is substantiated by histochemical and genetic analyses of marker genes typical or specific for osteogenesis , including the parathyroid hormone receptor , alkaline phosphatase , osteopontin , osteonectin , and osteocalcin . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Cloning and functional expression of a human parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Functional expression and signaling properties of cloned human parathyroid hormone receptor in Xenopus oocytes . ^^^ Expression of human parathyroid hormone receptor ( hPTHR ) was obtained in Xenopus oocytes . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Alterations in hormonal responses were not due to changes in parathyroid hormone receptor number or binding kinetics nor to alterations in adenylyl cyclase activity . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Converting parathyroid hormone related peptide ( PTHrP ) into a potent PTH 2 receptor agonist . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Coexpression and stimulation of parathyroid hormone receptor positively regulates slowly activating IsK channels expressed in Xenopus oocytes . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Coculture of CBMs with stromal cells of GCTBs or bone marrow did not result in bone resorption , although these stromal cells ( most expressing alkaline phosphatase but progressively losing parathyroid hormone receptor expression ) expressed mRNA for cytokines involved in OC differentiation , including macrophage CSF , granulocyte macrophage CSF , IL 11 , IL 6 , and stem cell factor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Histidine at position 5 is the specificity `` switch ' ' between two parathyroid hormone receptor subtypes . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| By reverse transcriptase polymerase chain reaction ( RT PCR ) analysis for mRNA , and by immunocytochemical study for protein , we studied the sequential expression in culture of multiple markers of the osteoblast phenotype alkaline phosphatase , osteopontin , parathyroid hormone receptor , types 1 and 3 procollagen , and osteocalcin as well as lipoprotein lipase ( LPL ) , a marker of the adipocyte phenotype . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The area of calcium physiology has been especially active due to the discovery of a new calcium regulating hormone , parathyroid hormone related protein , cloning of the parathyroid hormone receptor and identification of a cell membrane receptor for ionized calcium . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Changes in parathyroid hormone receptor binding affinity during egg laying : implications for calcium homeostasis in chicken . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Expression of the parathyroid hormone receptor and correlation with other osteoblastic parameters in fetal rat osteoblasts . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| These conditionally immortalized stromal cells can be induced to express a variety of markers that are typical for mature osteoblasts , e . g . , alkaline phosphatase activity and expression of functional parathyroid hormone receptor after stimulation with soluble osteogenic protein 1 ( sOP 1 ) . mRNA analysis revealed the expression and regulation of osteopontin , osteonectin , and collagen alpha 1 ( 1 ) as well as the inducibility of osteocalcin upon treatment with sOP 1 . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The effect of transforming growth factor beta 1 ( TGF beta 1 ) on the expression of mRNA for the parathyroid hormone receptor and binding of iodinated parathyroid hormone related protein in ROS 17 / 2 . 8 osteosarcoma cells was evaluated . ^^^ TGF beta 1 stimulated a 2 7 fold increase in steady state mRNA levels for the parathyroid hormone receptor at a maximal dose of 5 ng / ml , with increased levels of expression at 6 h of TGF beta 1 incubation , and peak levels at 8 24 h . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The PTH 1 receptor ( PTH1R ) signals in response to both PTH and parathyroid hormone related peptide ( PTHrP ) , whereas the PTH 2 receptor ( PTH2R ) responds only to PTH , not to PTHrP . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| As assessed by semiquantitative reverse transcriptase PCR after 4 days of culture at 39 . 5 degrees C , the six cell lines expressed similar mRNA levels both constitutively and in response to dexamethasone ( Dex ) and 1alpha , 25 dihydroxyvitamin D 3 ( 1 , 25 ( OH 2 ) D 3 ) for osteoblast ( alkaline phosphatase [ ALP ] , type 1 collagen [ Col 1 ] , osteocalcin [ OC ] , and parathyroid hormone receptor [ PTH R ] and adipocyte ( lipoprotein lipase [ LPL ] ) genes . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor mRNA was present in cells with the phenotypic appearance of osteoblasts , in close proximity to MNCs , and in occasional cells within pannus tissue , but not in the MNCs in bone resorption lacunae . ^^^ These findings demonstrate that osteoclasts within the rheumatoid lesion do not express parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Mutations involving any number of domains of the parathyroid hormone receptor , adenylate cyclase , or G proteins may alter the cellular response to parathyroid hormone . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Regulation of phosphate transport in the renal tubule through parathyroid hormone receptor : unexpected pathways . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Two such mutations in the parathyroid hormone receptor are associated with constitutive activity , manifesting clinically as Jansen ' s metaphyseal chondroplasia . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor interactions identified directly by photocross linking and molecular modeling studies . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Binding domain of human parathyroid hormone receptor : from conformation to function . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Regulation of renal parathyroid hormone receptor expression by 1 , 25 dihydroxyvitamin D 3 and retinoic acid . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Inactivating mutation in the human parathyroid hormone receptor type 1 gene in Blomstrand chondrodysplasia . ^^^ A single homozygous nucleotide exchange in exon E 3 of the gene encoding the parathyroid hormone receptor type 1 ( PTHR 1 ) was identified in an infant with Blomstrand chondrodysplasia born to consanguineous parents . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Cells expressing the STRO 1 antigen exclusively ( STRO 1+ / ALP ) , were found to exhibit qualities preosteoblastic in nature both functionally by their reduced ability to form a mineralized bone matrix over time , as measured by calcium release assay , and in the lack of their expression of various bone related markers including bone sialoprotein , osteopontin , and parathyroid hormone receptor based on reverse trancriptase polymerase chain reaction ( PCR ) analysis . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Megalin antagonizes activation of the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation independent inhibition of parathyroid hormone receptor signaling by G protein coupled receptor kinases . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Similar structures and shared switch mechanisms of the beta 2 adrenoceptor and the parathyroid hormone receptor . ^^^ Now we report engineering of metal binding sites bridging the cytoplasmic ends of these two helices in two other serpentine receptors , the beta 2 adrenoreceptor and the parathyroid hormone receptor ; occupancy of the metal binding site by Zn ( 2 ) markedly impairs the ability of each receptor to mediate ligand dependent activation of Gs , the stimulatory regulator of adenylyl cyclase . ^^^ We infer that these two receptors share with rhodopsin a common three dimensional architecture and an activation switch that requires movement , relative to one another , of helices 3 and 6 ; these inferences are surprising in the case of the parathyroid hormone receptor , a receptor that contains seven stretches of hydrophobic sequence but whose amino acid sequence otherwise shows no apparent similarity to those of receptors in the rhodopsin family . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| To investigate the molecular basis of osteogenesis in DC , we examined the temporal pattern of gene expression of the proliferation marker histone H 4 , immediate early response genes ( IEGs ) , c fos , c jun , c myc , osteoblast phenotype associated genes , osteocalcin ( OC ) , osteopontin ( OP ) , type 1 collagen ( COL1A1 ) , alkaline phosphatase ( ALP ) , parathyroid hormone receptor ( PTHR ) and matrix modifying enzyme , matrix metalloproteinase 9 ( MMP 9 ) . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Using reverse transcriptase polymerase chain reaction , cells in the four fractions were found to express different levels of transcripts for the parathyroid hormone receptor ( PTHr ) and bone sialoprotein ( BSP ) . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Direct identification of two contact sites for parathyroid hormone ( PTH ) in the novel PTH 2 receptor using photoaffinity cross linking . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction ( RT PCR ) phenotyping revealed abundant mRNA for osteocalcin ( OC ) , osteonectin ( ON ) , osteopontin ( OP ) , parathyroid hormone receptor ( PTHr ) , ALP , and procollagen type 1 ( ProI ) . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Comparison of rat and human parathyroid hormone 2 ( PTH 2 ) receptor activation : PTH is a low potency partial agonist at the rat PTH 2 receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Endocytosis of ligand human parathyroid hormone receptor 1 complexes is protein kinase C dependent and involves beta arrestin 2 . ^^^ Endocytosis and intracellular trafficking of the human parathyroid hormone receptor subtype 1 ( hPTH 1 Rc ) and its ligands was monitored independently by real time fluorescence microscopy in stably transfected HEK 293 cells . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Novel amino terminal parathyroid hormone fragments with enhanced potency in activating the type 1 parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor binding property in the shell gland of oviduct of the guineafowl during an oviposition cycle . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Although TIP 39 shares limited sequence homology with parathyroid hormone ( PTH ) , a comparison of the structural features of TIP 39 and PTH illustrates a similar topological display of residues of the N terminal helix important for PTH 2 receptor activation . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The structural features of the first extracellular loop ( ECL 1 ) of the parathyroid hormone receptor ( PTH1R ) in the presence of dodecylphosphocholine micelles have been determined using high resolution NMR techniques . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The N terminal fragment of human parathyroid hormone receptor 1 constitutes a hormone binding domain and reveals a distinct disulfide pattern . ^^^ To obtain structural and functional information on the N terminal receptor fragment of human parathyroid hormone receptor 1 ( PTHR 1 ) , the truncated receptor was expressed in the cytosol of Escherichia coli in the form of inclusion bodies . ^^^ These results demonstrate that the extracellular N terminal domain of the parathyroid hormone receptor ( PTHR 1 ) possesses a well defined , stable conformation , which shows a significant ligand binding activity . . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The most common , kidney specific transcripts were kidney androgen regulated protein ( 4 % of all transcripts ) , sodium phosphate cotransporter ( 0 . 3 % ) , renal cytochrome P 450 ( 0 . 3 % ) , parathyroid hormone receptor ( 0 . 1 % ) , and kidney specific cadherin ( 0 . 1 % ) . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| In this review , we divide the osteochondrodysplasias into groups based on their genetic relationships , including mutations in various types of collagen , fibroblast growth factor , cartilage oligomeric matrix protein , parathyroid hormone receptor , the diastrophic dysplasia sulfate transporter , enzymes such as steroid sulfatases , transcription factor SOX 9 , and a cysteine proteinase , cathepsin K . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| In experimental studies , transient transfection of Chinese hamster ovary cyclic AMP response element ( CRE ) luciferase reporter cells with cDNA for human parathyroid hormone receptor , glucagon receptor , and glucagon like peptide ( GLP 1 ) receptor showed cDNA concentration dependent constitutive activity with parathyroid hormone ( PTH 1 ) and glucagon . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Endogenous prostaglandin E 2 and insulin like growth factor 1 can modulate the levels of parathyroid hormone receptor in human osteoarthritic osteoblasts . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| This arrangement is similar to that of the ECD 1 of the parathyroid hormone receptor ( PTHR ) , suggesting a conserved structural motif in the N terminal domain of this family of receptors . . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor internalization is independent of protein kinase A and phospholipase C activation . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| We report here the involvement of recombinant human IL 11 ( rHuIL 11 ) in osteoblast differentiation in mouse mesenchymal progenitor cells , C3H10T1 / 2 . rHuIL 11 alone increased alkaline phosphatase ( ALP ) activity and upregulated expression levels of osteocalcin ( OC ) , bone sialo protein ( BSP ) , and parathyroid hormone receptor ( PTHR ) mRNA . rHuIL 11 had no effect on expression of type 2 collagen , peroxisome proliferator activated receptor gamma 2 ( PPAR gamma 2 ) , adipocyte fatty acid binding protein P 2 ( aP 2 ) , and myogenic MyoD protein ( MyoD ) . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Internalization determinants of the parathyroid hormone receptor differentially regulate beta arrestin / receptor association . beta Arrestins have been implicated in regulating internalization of the parathyroid hormone receptor ( PTHR ) , but the structural features in the receptor required for this effect are unknown . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Quantitative analysis of agonist dependent parathyroid hormone receptor trafficking in whole cells using a functional green fluorescent protein conjugate . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Of 64 genes known to be associated with bone metabolism , 7 showed weak evidence of linkage by SIBPAL analysis ( p < 0 . 05 ) : cadherin 13 ( CDH 13 ) , bone morphogenetic protein 4 ( BMP 4 ) , proteoglycan 1 ( PRG 1 ) , transforming growth factor beta 3 ( TGFb 3 ) , osteopontin ( OPN ) , parathyroid hormone receptor 1 ( PTHR 1 ) , and insulin like growth factor 1 ( IGF 1 ) . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Up regulation of parathyroid hormone receptor in cerebral arteries after subarachnoid hemorrhage in monkeys . ^^^ There was a marked increase in parathyroid hormone and parathyroid hormone receptor with time after SAH . ^^^ Immunoblotting demonstrated a significant increase in parathyroid hormone receptor protein . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues , a ligand of the parathyroid hormone receptor family . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor type 1 / Indian hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 activating mutations . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Using immunofluorescence confocal microscopy , we demonstrate , for the first time , that RAMPs interact with at least four additional receptors , the VPAC 1 vasoactive intestinal polypeptide / pituitary adenylate cyclase activating peptide receptor with all three RAMPs ; the glucagon and PTH 1 parathyroid hormone receptors with RAMP 2 ; and the PTH 2 receptor with RAMP 3 . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor recycling : role of receptor dephosphorylation and beta arrestin . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation with anti NaPi 4 antiserum and glutathione S transferase pull down with GST NaPi 4 showed that NaPi 4 associated with AKAP 79 , protein kinase A catalytic and regulatory subunits , and the parathyroid hormone receptor in opossum kidney cells . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Unlike the PTH 1 receptor , the PTH 2 receptor interacts extremely weakly with parathyroid hormone related peptide ( PTHrP ) . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Interaction of the parathyroid hormone receptor with the 14 3 3 protein . ^^^ We show that the parathyroid hormone receptor ( PTHR ) interacts with 14 3 3 and the proteins colocalize within the cell . 14 3 3 interacts with the C terminal tail of the receptor containing a consensus 14 3 3 binding motif , but additional binding sites are also used . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Expression patterns of parathyroid hormone related peptide ( PTHrP ) and parathyroid hormone receptor type 1 ( PTHR 1 ) during human development are suggestive of roles specific for each gene that are not mediated through the PTHrP / PTHR1 paracrine signaling pathway . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The mRNA expressions of osteopontin , parathyroid hormone receptor , osteocalcin , and bone sialoprotein were detected in the culture supplemented with autologous serum . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Type 1 parathyroid hormone receptor expression level modulates renal tone and plasma renin activity in spontaneously hypertensive rat . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Molecular characterization of a ligand tethered parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| PTH 2 receptor mediated inhibitory effect of parathyroid hormone and TIP 39 on cell proliferation . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Mechanisms of down regulation of the renal parathyroid hormone receptor in rats with chronic renal failure . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction ( RT PCR ) analysis revealed that HOSM 1 cells , an osteosarcoma cell line established from human mandible , expressed mRNA for osteoblastic markers , such as alkaline phosphatase , osteonectin , osteocalcin and parathyroid hormone receptor , thus exhibiting an osteoblastic phenotype . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| We used such direct measurements to investigate the activation of the alpha ( 2A ) adrenergic receptor ( alpha ( 2A ) AR ; neurotransmitter ) and the parathyroid hormone receptor ( PTHR ; hormone ) and observed much faster kinetics than expected : approximately 40 ms for the alpha ( 2A ) AR and approximately 1 s for the PTHR . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Activation independent parathyroid hormone receptor internalization is regulated by NHERF 1 ( EBP 50 ) . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Human ES cells are shown to respond to factors that promote osteogenesis , leading to activation of the osteogenic markers osteocalcin , parathyroid hormone receptor , bone sialoprotein , osteopontin , cbfa 1 , and collagen 1 . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Chromosomal loci including 1p36 , 2p22 25 , 11q12 13 , parathyroid hormone receptor type 1 ( PTHR 1 ) , interleukin 6 ( IL 6 ) , interleukin 1 alpha ( IL 1alpha ) and type 2 collagen A1 / vitamin D receptor ( COL11A1 / VDR ) have been linked or shown suggestive linkage with BMD in other populations . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Role of protein kinase A , phospholipase C and phospholipase D in parathyroid hormone receptor regulation of protein kinase Calpha and interleukin 6 in UMR 106 osteoblastic cells . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Transcripts for Na ( + ) bicarbonate cotransporter , Na ( + ) H ( + ) exchanger isoform 3 , Na , K ATPase , parathyroid hormone receptor , epidermal growth factor receptor , and vasopressin V 2 receptor were identified . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Homologous down regulation / desensitization of the parathyroid hormone receptor ( PTH1R ) / adenylate cyclase system has been demonstrated in uremia , and may contribute to parathyroid hormone ( PTH ) resistance ; however , additional studies have shown that parathyroidectomy fails to normalize the down regulation of the PTH1R . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone related protein ( PTHrP ) regulates proliferation and differentiation of osteoblastic cells via binding to the parathyroid hormone receptor ( PTH 1R ) . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The effects of teriparatide are mediated by the G protein dependent , parathyroid hormone receptor 1 in the cell membrane . ^^^ Other parathyroid hormone analogues are being investigated in clinical trials and the development of non peptide , small molecules targeted at the parathyroid hormone receptor may be envisaged . . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Some key molecular targets include the L type calcium channel ( alpha 1C isoform ) , a gadolinium sensitive stretch activated channel , P2Y ( 2 ) and P2X ( 7 ) purinergic receptors , EP ( 2 ) and EP ( 4 ) prostanoid receptors , and the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| In another population , parathyroid hormone receptor , alkaline phosphatase , and osteocalcin were also expressed at levels almost equal to those observed in long bone derived osteoblasts . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Recently , an activating mutation in the parathyroid hormone receptor type 1 ( PTHR 1 ) gene , c . 448C > T ( p . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal regulated kinases but is not required for regulation of cAMP signaling . ^^^ Agonist mediated activation of the type 1 parathyroid hormone receptor ( PTH1R ) results in several signaling events and receptor endocytosis . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| We confirmed that microgravity downregulated levels of alkaline phosphatase , runt related transcription factor 2 , osteomodulin , and parathyroid hormone receptor 1 mRNA ; upregulated cathepsin K mRNA ; and did not significantly affect bone morphogenic protein 4 and cystatin C protein levels . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Characterization of interactions of Na+ / H+ exchanger regulatory factor 1 with the parathyroid hormone receptor and phospholipase C . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The N terminal extracellular domain 23 60 of the calcitonin receptor like receptor in chimeras with the parathyroid hormone receptor mediates association with receptor activity modifying protein 1 . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| A quantitative PCR ( Q PCR ) method has been established to measure the mRNA expression levels of parathyroid hormone related protein ( PTHrP ) , parathyroid hormone receptor type 1 ( PTHR 1 ) , and calcium sensing receptor ( CaSR ) in sea bream ( Sparus aurata ) , using the housekeeping gene , beta actin , as endogenous control . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Response to continuous and pulsatile PTH dosing : a mathematical model for parathyroid hormone receptor kinetics . ^^^ In this paper , we propose a mathematical model for parathyroid hormone receptor ( PTH1R ) kinetics , focusing on the receptor ' s response to PTH dosing to discern bone formation responses from bone resorption . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Identification of the promoter region of the parathyroid hormone receptor gene responsible for transcriptional suppression by insulin like growth factor 1 . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| To demonstrate this approach , a ZFP TF activator of the human parathyroid hormone receptor 1 ( PTHR 1 ) gene was identified and introduced into HEK 293 cells ( negative for PTHR 1 ) . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Downregulation of parathyroid hormone receptor gene expression and osteoblastic dysfunction associated with skeletal resistance to parathyroid hormone in a rat model of renal failure with low turnover bone . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Increase in cell surface localization of parathyroid hormone receptor by cytoskeletal protein 4 . 1G . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Alkaline phosphatase activity and gene expression of alkaline phosphatase , parathyroid hormone receptor , osteopontin , and osteocalcin were up regulated compared with the control . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Turn on switch in parathyroid hormone receptor by a two step parathyroid hormone binding mechanism . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| BMP significantly increased the mRNA expression of type 1 collagen , ALP , osterix , osteocalcin , osteopontin , vascular endothelial growth factor ( VEGF ) , platelet derived growth factor ( PDGF ) A , and parathyroid hormone receptor time dependently during the osteoblastic differentiation . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Recent evidence has revealed important associations between the NHERF proteins and several G protein coupled receptors such as the beta 2 adrenergic receptor , the kappa opioid receptor , and the parathyroid hormone receptor , as well as growth factor tyrosine kinase receptors such as the platelet derived growth factor receptor and the epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Expression of PTHR 1 ( Parathyroid Hormone Receptor 1 ) transcripts was restricted to a narrow zone of prehypertrophic chondrocytes . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| At 2 days postirradiation , the decrease in parathyroid hormone related protein and parathyroid hormone receptor 1 expression in the irradiated growth plate transitional and hypertrophic zones was reversed in both of the combination groups but persisted in the groups treated with the individual drugs . ^^^ Combinations of radioprotectors may achieve their beneficial additive effects in the growth plate by decreasing the usual early drop in parathyroid hormone related protein and parathyroid hormone receptor 1 after irradiation , resulting in a cascade of parathyroid hormone related protein mediated events . . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| We introduced methionines one at a time into the region 163 176 of the parathyroid hormone receptor , and find that crosslinking occurs to the side chain of methionine over a range of 11 amino acids . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Type 1 parathyroid hormone receptor ( PTH1R ) nuclear trafficking : association of PTH1R with importin alpha 1 and beta . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| We previously demonstrated that activation of the Parathyroid Hormone Receptor ( PTH1R ) in osteoblastic cells increases the Notch ligand Jagged 1 and expands hematopoietic stem cells ( HSC ) through Notch signaling . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Role of calcium channels in carboxyl terminal parathyroid hormone receptor signaling . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The porcine PTH / PTHrP receptor has amino acid identity of 95 . 6 % , 80 . 4 % , and 88 . 7 % with human , opossum , and rat PTH / PTHrP receptors , respectively and 53 . 4 % identity to the recently cloned human PTH 2 receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The human PTH 2 receptor : binding and signal transduction properties of the stably expressed recombinant receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The PTH 2 receptor is a recently identified G protein coupled receptor activated by PTH . ^^^ We previously demonstrated using Northern blots that expression of PTH 2 receptor messenger RNA was greatest within the brain and occurred at lower levels in pancreas , testis , and placenta . ^^^ We have now obtained a complementary DNA encoding the rat PTH 2 receptor and used it to study the distribution of the PTH 2 receptor using in situ hybridization histochemistry . ^^^ PTH 2 receptor messenger RNA is abundantly expressed in arterial and cardiac endothelium and at lower levels in vascular smooth muscle . ^^^ These data suggest that the PTH 2 receptor may be responsible for PTH effects in a number of physiological systems . . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The PTH 2 receptor is expressed in several brain nuclei but we have been unable to detect mRNA encoding PTH , which is the only known ligand for the PTH 2 receptor , in the brain . ^^^ We now have evidence for a PTH 2 receptor selective ligand in an acid acetone extract made from bovine hypothalamus . ^^^ The partially purified extract activates the PTH 2 receptor more effectively than it activates the PTH / PTHrP receptor , while PTH activates these two receptors at similar concentration . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| A third receptor , which has been cloned recently and called `` PTH 2 receptor ' ' , recognizes solely PTH . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| However , when the equivalent of either the H223R or the T410P mutation was introduced into several other related receptors , including the PTH 2 receptor and the receptors for calcitonin , secretin , GH releasing hormone , glucagon like peptide 1 , and CRH , the resulting mutants failed to induce constitutive activity . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Previously it was shown that two divergent residues in PTH and PTHrP account for PTH 2 receptor selectivity ; position 23 ( Trp in PTH and Phe in PTHrP ) determines binding selectivity and position 5 ( Ile in PTH and His in PTHrP ) determines signaling selectivity . ^^^ To identify sites in the PTH 2 receptor involved in discriminating between His 5 and Ile 5 , we constructed PTH 2 receptor / PTH 1 receptor chimeras , expressed them in COS 7 cells , and tested for cAMP responsiveness to [ Trp 23 ] PTHrP ( 1 36 ) , and to the nondiscriminating peptide [ Ile 5 , Trp 23 ] PTHrP ( 1 36 ) ( the Phe 23 > Trp modification enabled high affinity binding of each ligand to the PTH 2 receptor ) . ^^^ The results thus indicate a functional interaction between two residues in the core region of the PTH 2 receptor and residue 5 of the ligand . . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| This method is useful for measurement of agonist and antagonist radioligand binding at the PTH 1 receptor and binding of [ 125I ] PTH ( 1 34 ) at the PTH 2 receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Only PTH activates the PTH 2 receptor . ^^^ Transfer of the PTH 2 receptor amino terminus to the PTH / PTHrP receptor eliminated high affinity PTHrP binding and significantly decreased activation by PTHrP . ^^^ A PTH / PTHrP receptor N terminus modified by deletion of the nonhomologous E 2 domain transferred weak PTHrP interaction to the PTH 2 receptor . ^^^ Introduction of the PTH 2 receptor third extracellular loop into the PTH / PTHrP receptor increased the EC 50 for PTH and PTHrP , while preserving high affinity PTH binding and eliminating high affinity PTHrP binding . ^^^ Similarly , transfer of the PTH / PTHrP receptor third extracellular loop preserved high affinity PTH binding by the PTH 2 receptor but decreased its activation . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The PTH 2 receptor is a G protein coupled receptor selectively activated by PTH . ^^^ We have now generated an antibody from a C terminal peptide sequence of the PTH 2 receptor and used this to study its cellular distribution . ^^^ Labeling with the antibody identified a number of endocrine cells expressing the PTH 2 receptor , including thyroid parafollicular cells , pancreatic islet D cells , and some gastrointestinal peptide synthesizing cells . ^^^ There was complete overlap of PTH 2 receptor labeling with somatostatin in pancreatic islets , and partial overlap with somatostatin in thyroid parafollicular cells and in the gastrointestinal tract . ^^^ These data suggest a broad role for the PTH 2 receptor , especially within the endocrine system , and provide a basis for experimental exploration of its physiology . . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| In particular , the [ Bpa 2 ] and [ Bpa 4 ] substituted analogs selectively antagonized and preferentially cross linked to the PTH 1 receptor and PTH 2 receptor , respectively . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Recent lines of work have led to the identification of constitutively active PTH1Rs in patients with Jansen ' s metaphyseal chondrodysplasia , the demonstration of inverse agonism by certain ligand analogs , and the discovery of the PTH 2 receptor subtype that responds to PTH but not PTHrP . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| N terminal truncation of TIP 39 reverses PTH 2 receptor / PTH1 receptor binding selectivity . ^^^ In this study , we investigated the molecular determinants of both ligand and receptor for the PTH 2 receptor selectivity of TIP 39 and quantitatively evaluated the role of molecular elements in the binding of TIP 39 to the PTH 2 and PTH 1 receptors . ^^^ A chimeric receptor composed of the N terminal extracellular domain of the PTH 1 receptor and the remainder ( juxtamembrane domain ) of the PTH 2 receptor ( P 2 NP1 ) was fully activated by TIP 39 ( E ( max ) = 98 % of the rPTH ( 1 34 ) , E ( max ) , EC ( 50 ) = 2 . 0 nm ) . ^^^ This receptor chimera bound TIP 39 with an equivalent affinity to the wild type PTH 2 receptor ( 2 . 3 and 2 . 0 nm , respectively ) . ^^^ Thus , the juxtamembrane receptor domain specifies the signaling and binding selectivity of TIP 39 for the PTH 2 receptor over the PTH 1 receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Tuberoinfundibular peptide of 39 residues ( TIP 39 ) was recently purified from bovine hypothalamus based on selective PTH 2 receptor activation . ^^^ PTH 2 receptor expression is greatest in the CNS , where it is concentrated in limbic , hypothalamic , and sensory areas , especially hypothalamic periventricular neurons , nerve terminals in the median eminence , superficial layers of the spinal cord dorsal horn , and the caudal part of the sensory trigeminal nucleus . ^^^ Thus TIP 39 and PTH 2 receptor influenced functions may range from pituitary and pancreatic hormone release to pain perception . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| We recently identified a novel antagonist , tuberoinfundibular peptide ( 7 39 ) [ TIP ( 7 39 ) ] , derived from the likely endogenous ligand for the PTH 2 receptor TIP 39 . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The tuberoinfundibular peptide TIP 39 [ TIP ( 1 39 ) ] , which exhibits only limited amino acid sequence homology with PTH and PTH related peptide ( PTHrP ) , stimulates cAMP accumulation in cells expressing the PTH 2 receptor ( PTH2R ) , but it is inactive at the PTH / PTHrP receptor ( PTH1R ) . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| The PTH 2 receptor is activated by TIP 39 but not by PTHrP . ^^^ PTH strongly activates the human PTH 2 receptor but is a weak partial agonist for rat and zebrafish PTH 2 receptors . ^^^ The orientation of receptor ligand interaction is highly similar for PTH and PTHrP binding to the PTH 1 receptor and TIP 39 interaction with the PTH 2 receptor . ^^^ The N interaction provides most of the PTH 1 receptor binding energy for PTH and PTHrP but provides less energy for PTH 2 receptor TIP 39 interaction . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Synthetic human and mouse TIP 39 showed indistinguishable potencies [ EC ( 50 ) : 0 . 54 ( human ) vs . 0 . 74 nM ( mouse ) ] at the human PTH 2 receptor stably expressed in LLCPK ( 1 ) cells ; furthermore , TIP ( 9 39 ) was an inhibitor of cAMP accumulation stimulated by either [ Tyr ( 34 ) ] PTH ( 1 34 ) amide or human / bovine TIP 39 . ^^^ Because PTH 2 receptor expression was previously shown to be highest in brain , pancreas , and testis , our findings are consistent with the notion that TIP 39 is a neuropeptide which may also have a role in spermatogenesis . . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Transcript expression of the tuberoinfundibular peptide ( TIP ) 39 / PTH2 receptor system and non PTH 1 receptor mediated tonic effects of TIP 39 and other PTH 2 receptor ligands in renal vessels . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| Recently , a new G protein coupled receptor with substantial implications for vascular function the PTH 2 receptor ( PTH 2 R ) has been identified , however , expression and distribution in humans and a possible regulation has not yet been studied . ^^^ We therefore investigated the expression of the PTH 2 receptor on human leukocytes in healthy subjects and in patients with hyperparathyroidism . ^^^ METHODS : PTH 2 receptor expression was quantified by flow cytometry ( FACS ) analysis on monocytes , lymphocytes and granulocytes that were isolated from peripheral blood ( hypotonic density gradient centrifugation ) and by immunohistochemistry using a specific alpha PTH 2 R antibody produced in rabbit . ^^^ RESULTS : Mean relative antigen density of the PTH 2 receptor and percentage of positive cells in healthy subjects was 19 + / 5 and 90 + / 6 % on granulocytes , 5 + / 2 and 55 + / 19 % on monocytes , and 24 + / 7 and 21 + / 7 % on lymphocytes . ^^^ A significant and inverse correlation was found between plasma PTH concentrations and the mean PTH 2 receptor expression on granulocytes ( r = 0 . 41 , p < 0 . 05 ) . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| In fact there is more than one receptor the PTH 2 receptor and a putative carboxy terminal PTH receptor . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| For the human PTH 2 receptor PTH was a full agonist for increasing cAMP , a partial agonist for increasing [ Ca2+ ] 1 , and bound with high affinity ( 18 nM ) . ^^^ Multiple regions throughout the receptor are required for the PTH PTH 2 receptor complex to adopt a high affinity active state : inserting the rat receptor ' s N terminal domain , EL 1 or EL2 / 3 , into the human receptor increased PTH ' s EC 50 and reciprocal exchanges did not reduce EC 50 . ^^^ These insights should contribute to the development of a high affinity PTH 2 receptor antagonist , for investigating the receptor ' s physiological role . . ^^^ |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01270 and P49190 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.53956504 |
| The type 1 parathyroid hormone receptor ( PTHR 1 ) binds , with equal affinity , two ligands with distinct biological functions : PTH , the major peptide hormone controlling calcium homeostasis , and the paracrine factor , PTH related peptide ( PTHrP ) , a local regulator of cellular proliferation and differentiation . 0.53956504^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Autoantibodies to parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Solubilization of a parathyroid hormone receptor from bovine kidney cortex plasma membranes . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| A new technic to evaluate the sensitivity of the renal parathyroid hormone receptor in man ] . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| A series of clinical studies suggest that the primary defect underlying pseudohypoparathyroidism is an abnormality of the parathyroid hormone receptor adenylate cyclase complex of the renal cortical cell plasma membrane . ^^^ These results indicate that the defect in the parathyroid hormone receptor adenylate cyclase complex of the renal cell membranes , in our patient with pseudohypoparathyroidism , is an abnormal nucleotide receptor site of decreased activity . ^^^ Such a defect may result in partial uncoupling of the parathyroid hormone receptor and adenylate cyclase , rendering the organ refractory to hormonal stimulation . . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| D reduces parathyroid hormone receptor number in ROS 17 / 2 . 8 cells and prevents the glucocorticoid induced increase in these receptors : relationship to adenylate cyclase activation . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Application to fluorescence activated cell sorting of parathyroid hormone receptor bearing cells . [ Nle 8 , 18 , Tyr 34 ] bPTH ( 1 34 ) amide ( NlePTH ) was biotinylated using sulfosuccinimidyl 6 ( biotinamido ) hexanoate , in dimethyl sulfoxide , and the multiple resulting peptides peaks were separated by reverse phase high performance liquid chromatography . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Biochemical and morphological characterization of parathyroid hormone receptor binding to the rat osteosarcoma cell line UMR 106 . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Nonetheless , both peptides activate the parathyroid hormone receptor to produce hypercalcemia . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| These characteristics are shared by the parathyroid hormone receptor agonists associated with humoral hypercalcemia of malignancy , which suggests that normal human keratinocytes may produce a factor related to that produced by malignant tumors associated with humoral hypercalcemia of malignancy . . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Biotinylated parathyroid hormone as a probe for the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The canine renal parathyroid hormone receptor is a glycoprotein : characterization and partial purification . ^^^ Covalent labeling of the canine renal parathyroid hormone receptor with [ 125I ] bPTH ( 1 34 ) reveals several major binding components that display characteristics consistent with a physiologically relevant adenylate cyclase linked receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Effect of transforming growth factor beta on parathyroid hormone receptor binding and cAMP formation in rat osteosarcoma cells . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| This dual coupling is also a characteristic of the parathyroid hormone receptor , which has significant homology in amino acid sequence with the CT receptor . . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Inhibition of in vitro bone resorption by a parathyroid hormone receptor antagonist in the canine adenocarcinoma model of humoral hypercalcemia of malignancy . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor activation is restored by parathyroidectomy , beta adrenergic agonists no longer desensitize in older animals , and muscarinic receptors from senescent rats pharmacologically mimic desensitized receptors . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Structural properties of the renal parathyroid hormone receptor : hydrodynamic analysis and protease sensitivity . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor in human placental syncytiotrophoblast brush border and basal plasma membranes . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| A factor produced by cultured rat Leydig tumor ( Rice 500 ) cells associated with humoral hypercalcemia stimulates adenosine 3 ' , 5 ' monophosphate production via the parathyroid hormone receptor in human skin fibroblasts . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Evaluation of renal parathyroid hormone receptor function in myotonic dystrophy . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation of the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Covalent labeling of a high affinity , guanyl nucleotide sensitive parathyroid hormone receptor in canine renal cortex . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The AC stimulating activity of CAC 8 appeared to bind to the parathyroid hormone receptor of ROS , UMR , and OK cells since addition of the parathyroid hormone receptor antagonist , [ 8 , 18norleucine , 34tyrosine ] BPTH ( 3 34 ) amide , inhibited CAC 8 mediated cyclic adenosine 5 ' monophosphate production and alone did not stimulate AC activity . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor in bovine kidney cortex plasma membranes . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| These studies demonstrate that it is possible to alter the amino terminus of parathyroid hormone analogues without causing a dramatic decline in affinity for the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Studies were undertaken to identify and characterize components of the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor in intact embryonic chicken bone : characterization and cellular localization . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Coupling of the canine renal parathyroid hormone receptor to adenylate cyclase : modulation by guanyl nucleotides and N ethylmaleimide . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| In contrast , OP 1 treatment stimulated phenotypic differentiation in ROS 17 / 2 . 8 cells , as indicated by enhanced 1 ) alkaline phosphatase activity ( 4 fold ) ; 2 ) alkaline phosphatase mRNA ( 5 fold ) ; 3 ) parathyroid hormone receptor mRNA ( 2 fold ) , and 4 ) parathyroid hormone stimulated adenosine 3 ' , 5 ' cyclic monophosphate accumulation ( 2 fold ) . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| We report the in vivo whole body distribution and blood plasma pharmacokinetics of the parathyroid hormone receptor antagonist [ Nle 8 , 18 , D Trp 12 , monoiodinated Tyr 34 ] bPTH ( 7 34 ) amide to determine parameters that are likely to affect its administration regimen . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Heparin insensitive calcium release from intracellular stores triggered by the recombinant human parathyroid hormone receptor . 1 . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Coordinate regulation of rat renal parathyroid hormone receptor mRNA and Na Pi cotransporter mRNA and protein . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Determinants of [ Arg 2 ] PTH ( 1 34 ) binding and signaling in the transmembrane region of the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Intron positions were similar to the positions of introns in growth hormone releasing hormone receptor and parathyroid hormone receptor , two receptors belonging to the same receptor family as the glucagon receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| A C terminally truncated human parathyroid hormone receptor is functional and activates multiple G proteins . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| BsmI polymorphism at the parathyroid hormone receptor locus ( PTHR ) in three populations . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The osteogenic differentiation potential of C3H10T1 / 2 cells is substantiated by histochemical and genetic analyses of marker genes typical or specific for osteogenesis , including the parathyroid hormone receptor , alkaline phosphatase , osteopontin , osteonectin , and osteocalcin . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Cloning and functional expression of a human parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Functional expression and signaling properties of cloned human parathyroid hormone receptor in Xenopus oocytes . ^^^ Expression of human parathyroid hormone receptor ( hPTHR ) was obtained in Xenopus oocytes . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Alterations in hormonal responses were not due to changes in parathyroid hormone receptor number or binding kinetics nor to alterations in adenylyl cyclase activity . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Coexpression and stimulation of parathyroid hormone receptor positively regulates slowly activating IsK channels expressed in Xenopus oocytes . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Coculture of CBMs with stromal cells of GCTBs or bone marrow did not result in bone resorption , although these stromal cells ( most expressing alkaline phosphatase but progressively losing parathyroid hormone receptor expression ) expressed mRNA for cytokines involved in OC differentiation , including macrophage CSF , granulocyte macrophage CSF , IL 11 , IL 6 , and stem cell factor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Histidine at position 5 is the specificity `` switch ' ' between two parathyroid hormone receptor subtypes . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| By reverse transcriptase polymerase chain reaction ( RT PCR ) analysis for mRNA , and by immunocytochemical study for protein , we studied the sequential expression in culture of multiple markers of the osteoblast phenotype alkaline phosphatase , osteopontin , parathyroid hormone receptor , types 1 and 3 procollagen , and osteocalcin as well as lipoprotein lipase ( LPL ) , a marker of the adipocyte phenotype . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The area of calcium physiology has been especially active due to the discovery of a new calcium regulating hormone , parathyroid hormone related protein , cloning of the parathyroid hormone receptor and identification of a cell membrane receptor for ionized calcium . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Changes in parathyroid hormone receptor binding affinity during egg laying : implications for calcium homeostasis in chicken . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Expression of the parathyroid hormone receptor and correlation with other osteoblastic parameters in fetal rat osteoblasts . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| These conditionally immortalized stromal cells can be induced to express a variety of markers that are typical for mature osteoblasts , e . g . , alkaline phosphatase activity and expression of functional parathyroid hormone receptor after stimulation with soluble osteogenic protein 1 ( sOP 1 ) . mRNA analysis revealed the expression and regulation of osteopontin , osteonectin , and collagen alpha 1 ( 1 ) as well as the inducibility of osteocalcin upon treatment with sOP 1 . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The effect of transforming growth factor beta 1 ( TGF beta 1 ) on the expression of mRNA for the parathyroid hormone receptor and binding of iodinated parathyroid hormone related protein in ROS 17 / 2 . 8 osteosarcoma cells was evaluated . ^^^ TGF beta 1 stimulated a 2 7 fold increase in steady state mRNA levels for the parathyroid hormone receptor at a maximal dose of 5 ng / ml , with increased levels of expression at 6 h of TGF beta 1 incubation , and peak levels at 8 24 h . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| As assessed by semiquantitative reverse transcriptase PCR after 4 days of culture at 39 . 5 degrees C , the six cell lines expressed similar mRNA levels both constitutively and in response to dexamethasone ( Dex ) and 1alpha , 25 dihydroxyvitamin D 3 ( 1 , 25 ( OH 2 ) D 3 ) for osteoblast ( alkaline phosphatase [ ALP ] , type 1 collagen [ Col 1 ] , osteocalcin [ OC ] , and parathyroid hormone receptor [ PTH R ] and adipocyte ( lipoprotein lipase [ LPL ] ) genes . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor mRNA was present in cells with the phenotypic appearance of osteoblasts , in close proximity to MNCs , and in occasional cells within pannus tissue , but not in the MNCs in bone resorption lacunae . ^^^ These findings demonstrate that osteoclasts within the rheumatoid lesion do not express parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Mutations involving any number of domains of the parathyroid hormone receptor , adenylate cyclase , or G proteins may alter the cellular response to parathyroid hormone . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Regulation of phosphate transport in the renal tubule through parathyroid hormone receptor : unexpected pathways . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Two such mutations in the parathyroid hormone receptor are associated with constitutive activity , manifesting clinically as Jansen ' s metaphyseal chondroplasia . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor interactions identified directly by photocross linking and molecular modeling studies . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Binding domain of human parathyroid hormone receptor : from conformation to function . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Regulation of renal parathyroid hormone receptor expression by 1 , 25 dihydroxyvitamin D 3 and retinoic acid . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Inactivating mutation in the human parathyroid hormone receptor type 1 gene in Blomstrand chondrodysplasia . ^^^ A single homozygous nucleotide exchange in exon E 3 of the gene encoding the parathyroid hormone receptor type 1 ( PTHR 1 ) was identified in an infant with Blomstrand chondrodysplasia born to consanguineous parents . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Cells expressing the STRO 1 antigen exclusively ( STRO 1+ / ALP ) , were found to exhibit qualities preosteoblastic in nature both functionally by their reduced ability to form a mineralized bone matrix over time , as measured by calcium release assay , and in the lack of their expression of various bone related markers including bone sialoprotein , osteopontin , and parathyroid hormone receptor based on reverse trancriptase polymerase chain reaction ( PCR ) analysis . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Megalin antagonizes activation of the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation independent inhibition of parathyroid hormone receptor signaling by G protein coupled receptor kinases . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Similar structures and shared switch mechanisms of the beta 2 adrenoceptor and the parathyroid hormone receptor . ^^^ Now we report engineering of metal binding sites bridging the cytoplasmic ends of these two helices in two other serpentine receptors , the beta 2 adrenoreceptor and the parathyroid hormone receptor ; occupancy of the metal binding site by Zn ( 2 ) markedly impairs the ability of each receptor to mediate ligand dependent activation of Gs , the stimulatory regulator of adenylyl cyclase . ^^^ We infer that these two receptors share with rhodopsin a common three dimensional architecture and an activation switch that requires movement , relative to one another , of helices 3 and 6 ; these inferences are surprising in the case of the parathyroid hormone receptor , a receptor that contains seven stretches of hydrophobic sequence but whose amino acid sequence otherwise shows no apparent similarity to those of receptors in the rhodopsin family . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| To investigate the molecular basis of osteogenesis in DC , we examined the temporal pattern of gene expression of the proliferation marker histone H 4 , immediate early response genes ( IEGs ) , c fos , c jun , c myc , osteoblast phenotype associated genes , osteocalcin ( OC ) , osteopontin ( OP ) , type 1 collagen ( COL1A1 ) , alkaline phosphatase ( ALP ) , parathyroid hormone receptor ( PTHR ) and matrix modifying enzyme , matrix metalloproteinase 9 ( MMP 9 ) . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Using reverse transcriptase polymerase chain reaction , cells in the four fractions were found to express different levels of transcripts for the parathyroid hormone receptor ( PTHr ) and bone sialoprotein ( BSP ) . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction ( RT PCR ) phenotyping revealed abundant mRNA for osteocalcin ( OC ) , osteonectin ( ON ) , osteopontin ( OP ) , parathyroid hormone receptor ( PTHr ) , ALP , and procollagen type 1 ( ProI ) . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Endocytosis of ligand human parathyroid hormone receptor 1 complexes is protein kinase C dependent and involves beta arrestin 2 . ^^^ Endocytosis and intracellular trafficking of the human parathyroid hormone receptor subtype 1 ( hPTH 1 Rc ) and its ligands was monitored independently by real time fluorescence microscopy in stably transfected HEK 293 cells . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Novel amino terminal parathyroid hormone fragments with enhanced potency in activating the type 1 parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor binding property in the shell gland of oviduct of the guineafowl during an oviposition cycle . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The structural features of the first extracellular loop ( ECL 1 ) of the parathyroid hormone receptor ( PTH1R ) in the presence of dodecylphosphocholine micelles have been determined using high resolution NMR techniques . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The N terminal fragment of human parathyroid hormone receptor 1 constitutes a hormone binding domain and reveals a distinct disulfide pattern . ^^^ To obtain structural and functional information on the N terminal receptor fragment of human parathyroid hormone receptor 1 ( PTHR 1 ) , the truncated receptor was expressed in the cytosol of Escherichia coli in the form of inclusion bodies . ^^^ These results demonstrate that the extracellular N terminal domain of the parathyroid hormone receptor ( PTHR 1 ) possesses a well defined , stable conformation , which shows a significant ligand binding activity . . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The most common , kidney specific transcripts were kidney androgen regulated protein ( 4 % of all transcripts ) , sodium phosphate cotransporter ( 0 . 3 % ) , renal cytochrome P 450 ( 0 . 3 % ) , parathyroid hormone receptor ( 0 . 1 % ) , and kidney specific cadherin ( 0 . 1 % ) . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| In this review , we divide the osteochondrodysplasias into groups based on their genetic relationships , including mutations in various types of collagen , fibroblast growth factor , cartilage oligomeric matrix protein , parathyroid hormone receptor , the diastrophic dysplasia sulfate transporter , enzymes such as steroid sulfatases , transcription factor SOX 9 , and a cysteine proteinase , cathepsin K . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| In experimental studies , transient transfection of Chinese hamster ovary cyclic AMP response element ( CRE ) luciferase reporter cells with cDNA for human parathyroid hormone receptor , glucagon receptor , and glucagon like peptide ( GLP 1 ) receptor showed cDNA concentration dependent constitutive activity with parathyroid hormone ( PTH 1 ) and glucagon . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Endogenous prostaglandin E 2 and insulin like growth factor 1 can modulate the levels of parathyroid hormone receptor in human osteoarthritic osteoblasts . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| This arrangement is similar to that of the ECD 1 of the parathyroid hormone receptor ( PTHR ) , suggesting a conserved structural motif in the N terminal domain of this family of receptors . . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor internalization is independent of protein kinase A and phospholipase C activation . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| We report here the involvement of recombinant human IL 11 ( rHuIL 11 ) in osteoblast differentiation in mouse mesenchymal progenitor cells , C3H10T1 / 2 . rHuIL 11 alone increased alkaline phosphatase ( ALP ) activity and upregulated expression levels of osteocalcin ( OC ) , bone sialo protein ( BSP ) , and parathyroid hormone receptor ( PTHR ) mRNA . rHuIL 11 had no effect on expression of type 2 collagen , peroxisome proliferator activated receptor gamma 2 ( PPAR gamma 2 ) , adipocyte fatty acid binding protein P 2 ( aP 2 ) , and myogenic MyoD protein ( MyoD ) . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Internalization determinants of the parathyroid hormone receptor differentially regulate beta arrestin / receptor association . beta Arrestins have been implicated in regulating internalization of the parathyroid hormone receptor ( PTHR ) , but the structural features in the receptor required for this effect are unknown . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Quantitative analysis of agonist dependent parathyroid hormone receptor trafficking in whole cells using a functional green fluorescent protein conjugate . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Of 64 genes known to be associated with bone metabolism , 7 showed weak evidence of linkage by SIBPAL analysis ( p < 0 . 05 ) : cadherin 13 ( CDH 13 ) , bone morphogenetic protein 4 ( BMP 4 ) , proteoglycan 1 ( PRG 1 ) , transforming growth factor beta 3 ( TGFb 3 ) , osteopontin ( OPN ) , parathyroid hormone receptor 1 ( PTHR 1 ) , and insulin like growth factor 1 ( IGF 1 ) . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Type 1 parathyroid hormone receptor expression level modulates renal tone and plasma renin activity in spontaneously hypertensive rat . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Molecular characterization of a ligand tethered parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Up regulation of parathyroid hormone receptor in cerebral arteries after subarachnoid hemorrhage in monkeys . ^^^ There was a marked increase in parathyroid hormone and parathyroid hormone receptor with time after SAH . ^^^ Immunoblotting demonstrated a significant increase in parathyroid hormone receptor protein . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues , a ligand of the parathyroid hormone receptor family . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor type 1 / Indian hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 activating mutations . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor recycling : role of receptor dephosphorylation and beta arrestin . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation with anti NaPi 4 antiserum and glutathione S transferase pull down with GST NaPi 4 showed that NaPi 4 associated with AKAP 79 , protein kinase A catalytic and regulatory subunits , and the parathyroid hormone receptor in opossum kidney cells . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Interaction of the parathyroid hormone receptor with the 14 3 3 protein . ^^^ We show that the parathyroid hormone receptor ( PTHR ) interacts with 14 3 3 and the proteins colocalize within the cell . 14 3 3 interacts with the C terminal tail of the receptor containing a consensus 14 3 3 binding motif , but additional binding sites are also used . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Expression patterns of parathyroid hormone related peptide ( PTHrP ) and parathyroid hormone receptor type 1 ( PTHR 1 ) during human development are suggestive of roles specific for each gene that are not mediated through the PTHrP / PTHR1 paracrine signaling pathway . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The mRNA expressions of osteopontin , parathyroid hormone receptor , osteocalcin , and bone sialoprotein were detected in the culture supplemented with autologous serum . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Mechanisms of down regulation of the renal parathyroid hormone receptor in rats with chronic renal failure . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction ( RT PCR ) analysis revealed that HOSM 1 cells , an osteosarcoma cell line established from human mandible , expressed mRNA for osteoblastic markers , such as alkaline phosphatase , osteonectin , osteocalcin and parathyroid hormone receptor , thus exhibiting an osteoblastic phenotype . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| We used such direct measurements to investigate the activation of the alpha ( 2A ) adrenergic receptor ( alpha ( 2A ) AR ; neurotransmitter ) and the parathyroid hormone receptor ( PTHR ; hormone ) and observed much faster kinetics than expected : approximately 40 ms for the alpha ( 2A ) AR and approximately 1 s for the PTHR . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Activation independent parathyroid hormone receptor internalization is regulated by NHERF 1 ( EBP 50 ) . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Human ES cells are shown to respond to factors that promote osteogenesis , leading to activation of the osteogenic markers osteocalcin , parathyroid hormone receptor , bone sialoprotein , osteopontin , cbfa 1 , and collagen 1 . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Chromosomal loci including 1p36 , 2p22 25 , 11q12 13 , parathyroid hormone receptor type 1 ( PTHR 1 ) , interleukin 6 ( IL 6 ) , interleukin 1 alpha ( IL 1alpha ) and type 2 collagen A1 / vitamin D receptor ( COL11A1 / VDR ) have been linked or shown suggestive linkage with BMD in other populations . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Role of protein kinase A , phospholipase C and phospholipase D in parathyroid hormone receptor regulation of protein kinase Calpha and interleukin 6 in UMR 106 osteoblastic cells . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Transcripts for Na ( + ) bicarbonate cotransporter , Na ( + ) H ( + ) exchanger isoform 3 , Na , K ATPase , parathyroid hormone receptor , epidermal growth factor receptor , and vasopressin V 2 receptor were identified . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Homologous down regulation / desensitization of the parathyroid hormone receptor ( PTH1R ) / adenylate cyclase system has been demonstrated in uremia , and may contribute to parathyroid hormone ( PTH ) resistance ; however , additional studies have shown that parathyroidectomy fails to normalize the down regulation of the PTH1R . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone related protein ( PTHrP ) regulates proliferation and differentiation of osteoblastic cells via binding to the parathyroid hormone receptor ( PTH 1R ) . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The effects of teriparatide are mediated by the G protein dependent , parathyroid hormone receptor 1 in the cell membrane . ^^^ Other parathyroid hormone analogues are being investigated in clinical trials and the development of non peptide , small molecules targeted at the parathyroid hormone receptor may be envisaged . . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Some key molecular targets include the L type calcium channel ( alpha 1C isoform ) , a gadolinium sensitive stretch activated channel , P2Y ( 2 ) and P2X ( 7 ) purinergic receptors , EP ( 2 ) and EP ( 4 ) prostanoid receptors , and the parathyroid hormone receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| In another population , parathyroid hormone receptor , alkaline phosphatase , and osteocalcin were also expressed at levels almost equal to those observed in long bone derived osteoblasts . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Recently , an activating mutation in the parathyroid hormone receptor type 1 ( PTHR 1 ) gene , c . 448C > T ( p . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal regulated kinases but is not required for regulation of cAMP signaling . ^^^ Agonist mediated activation of the type 1 parathyroid hormone receptor ( PTH1R ) results in several signaling events and receptor endocytosis . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| We confirmed that microgravity downregulated levels of alkaline phosphatase , runt related transcription factor 2 , osteomodulin , and parathyroid hormone receptor 1 mRNA ; upregulated cathepsin K mRNA ; and did not significantly affect bone morphogenic protein 4 and cystatin C protein levels . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Characterization of interactions of Na+ / H+ exchanger regulatory factor 1 with the parathyroid hormone receptor and phospholipase C . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The N terminal extracellular domain 23 60 of the calcitonin receptor like receptor in chimeras with the parathyroid hormone receptor mediates association with receptor activity modifying protein 1 . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| A quantitative PCR ( Q PCR ) method has been established to measure the mRNA expression levels of parathyroid hormone related protein ( PTHrP ) , parathyroid hormone receptor type 1 ( PTHR 1 ) , and calcium sensing receptor ( CaSR ) in sea bream ( Sparus aurata ) , using the housekeeping gene , beta actin , as endogenous control . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Response to continuous and pulsatile PTH dosing : a mathematical model for parathyroid hormone receptor kinetics . ^^^ In this paper , we propose a mathematical model for parathyroid hormone receptor ( PTH1R ) kinetics , focusing on the receptor ' s response to PTH dosing to discern bone formation responses from bone resorption . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Identification of the promoter region of the parathyroid hormone receptor gene responsible for transcriptional suppression by insulin like growth factor 1 . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| To demonstrate this approach , a ZFP TF activator of the human parathyroid hormone receptor 1 ( PTHR 1 ) gene was identified and introduced into HEK 293 cells ( negative for PTHR 1 ) . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Downregulation of parathyroid hormone receptor gene expression and osteoblastic dysfunction associated with skeletal resistance to parathyroid hormone in a rat model of renal failure with low turnover bone . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Increase in cell surface localization of parathyroid hormone receptor by cytoskeletal protein 4 . 1G . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Alkaline phosphatase activity and gene expression of alkaline phosphatase , parathyroid hormone receptor , osteopontin , and osteocalcin were up regulated compared with the control . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Turn on switch in parathyroid hormone receptor by a two step parathyroid hormone binding mechanism . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| BMP significantly increased the mRNA expression of type 1 collagen , ALP , osterix , osteocalcin , osteopontin , vascular endothelial growth factor ( VEGF ) , platelet derived growth factor ( PDGF ) A , and parathyroid hormone receptor time dependently during the osteoblastic differentiation . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Recent evidence has revealed important associations between the NHERF proteins and several G protein coupled receptors such as the beta 2 adrenergic receptor , the kappa opioid receptor , and the parathyroid hormone receptor , as well as growth factor tyrosine kinase receptors such as the platelet derived growth factor receptor and the epidermal growth factor receptor . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Expression of PTHR 1 ( Parathyroid Hormone Receptor 1 ) transcripts was restricted to a narrow zone of prehypertrophic chondrocytes . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| At 2 days postirradiation , the decrease in parathyroid hormone related protein and parathyroid hormone receptor 1 expression in the irradiated growth plate transitional and hypertrophic zones was reversed in both of the combination groups but persisted in the groups treated with the individual drugs . ^^^ Combinations of radioprotectors may achieve their beneficial additive effects in the growth plate by decreasing the usual early drop in parathyroid hormone related protein and parathyroid hormone receptor 1 after irradiation , resulting in a cascade of parathyroid hormone related protein mediated events . . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| We introduced methionines one at a time into the region 163 176 of the parathyroid hormone receptor , and find that crosslinking occurs to the side chain of methionine over a range of 11 amino acids . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Type 1 parathyroid hormone receptor ( PTH1R ) nuclear trafficking : association of PTH1R with importin alpha 1 and beta . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| We previously demonstrated that activation of the Parathyroid Hormone Receptor ( PTH1R ) in osteoblastic cells increases the Notch ligand Jagged 1 and expands hematopoietic stem cells ( HSC ) through Notch signaling . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Role of calcium channels in carboxyl terminal parathyroid hormone receptor signaling . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Identification and functional expression of a receptor selectively recognizing parathyroid hormone , the PTH 2 receptor . ^^^ We have identified a G protein coupled receptor specifically activated by parathyroid hormone , which we refer to as the PTH 2 receptor . ^^^ The PTH 2 receptor is much more selective in ligand recognition and appears to have a more specific tissue distribution . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The porcine PTH / PTHrP receptor has amino acid identity of 95 . 6 % , 80 . 4 % , and 88 . 7 % with human , opossum , and rat PTH / PTHrP receptors , respectively and 53 . 4 % identity to the recently cloned human PTH 2 receptor . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Converting parathyroid hormone related peptide ( PTHrP ) into a potent PTH 2 receptor agonist . ^^^ Recently , a homologous receptor , the PTH 2 receptor , was obtained from rat and human brain cDNA libraries . ^^^ To begin to define residues involved in the ligand specificity of the PTH 2 receptor , we studied the interaction of several PTH / PTHrP hybrid ligands and other related peptide analogs with the human PTH 2 receptor . ^^^ By changing these two residues of PTHrP to the corresponding residues of PTH , we were able to convert PTHrP into a ligand that avidly bound to the PTH 2 receptor and fully and potently stimulated cAMP formation . ^^^ Changing residue 23 alone yielded [ Trp 23 ] hPTHrP ( 1 36 ) , which was an antagonist for the PTH 2 receptor , but a full agonist for the PTH / PTHrP receptor . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The human PTH 2 receptor : binding and signal transduction properties of the stably expressed recombinant receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The PTH 2 receptor is a recently identified G protein coupled receptor activated by PTH . ^^^ We previously demonstrated using Northern blots that expression of PTH 2 receptor messenger RNA was greatest within the brain and occurred at lower levels in pancreas , testis , and placenta . ^^^ We have now obtained a complementary DNA encoding the rat PTH 2 receptor and used it to study the distribution of the PTH 2 receptor using in situ hybridization histochemistry . ^^^ PTH 2 receptor messenger RNA is abundantly expressed in arterial and cardiac endothelium and at lower levels in vascular smooth muscle . ^^^ These data suggest that the PTH 2 receptor may be responsible for PTH effects in a number of physiological systems . . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The PTH 2 receptor is expressed in several brain nuclei but we have been unable to detect mRNA encoding PTH , which is the only known ligand for the PTH 2 receptor , in the brain . ^^^ We now have evidence for a PTH 2 receptor selective ligand in an acid acetone extract made from bovine hypothalamus . ^^^ The partially purified extract activates the PTH 2 receptor more effectively than it activates the PTH / PTHrP receptor , while PTH activates these two receptors at similar concentration . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| However , when the equivalent of either the H223R or the T410P mutation was introduced into several other related receptors , including the PTH 2 receptor and the receptors for calcitonin , secretin , GH releasing hormone , glucagon like peptide 1 , and CRH , the resulting mutants failed to induce constitutive activity . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Previously it was shown that two divergent residues in PTH and PTHrP account for PTH 2 receptor selectivity ; position 23 ( Trp in PTH and Phe in PTHrP ) determines binding selectivity and position 5 ( Ile in PTH and His in PTHrP ) determines signaling selectivity . ^^^ To identify sites in the PTH 2 receptor involved in discriminating between His 5 and Ile 5 , we constructed PTH 2 receptor / PTH 1 receptor chimeras , expressed them in COS 7 cells , and tested for cAMP responsiveness to [ Trp 23 ] PTHrP ( 1 36 ) , and to the nondiscriminating peptide [ Ile 5 , Trp 23 ] PTHrP ( 1 36 ) ( the Phe 23 > Trp modification enabled high affinity binding of each ligand to the PTH 2 receptor ) . ^^^ The results thus indicate a functional interaction between two residues in the core region of the PTH 2 receptor and residue 5 of the ligand . . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The PTH 1 receptor ( PTH1R ) signals in response to both PTH and parathyroid hormone related peptide ( PTHrP ) , whereas the PTH 2 receptor ( PTH2R ) responds only to PTH , not to PTHrP . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Only PTH activates the PTH 2 receptor . ^^^ Transfer of the PTH 2 receptor amino terminus to the PTH / PTHrP receptor eliminated high affinity PTHrP binding and significantly decreased activation by PTHrP . ^^^ A PTH / PTHrP receptor N terminus modified by deletion of the nonhomologous E 2 domain transferred weak PTHrP interaction to the PTH 2 receptor . ^^^ Introduction of the PTH 2 receptor third extracellular loop into the PTH / PTHrP receptor increased the EC 50 for PTH and PTHrP , while preserving high affinity PTH binding and eliminating high affinity PTHrP binding . ^^^ Similarly , transfer of the PTH / PTHrP receptor third extracellular loop preserved high affinity PTH binding by the PTH 2 receptor but decreased its activation . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| A third receptor , which has been cloned recently and called `` PTH 2 receptor ' ' , recognizes solely PTH . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| This method is useful for measurement of agonist and antagonist radioligand binding at the PTH 1 receptor and binding of [ 125I ] PTH ( 1 34 ) at the PTH 2 receptor . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The PTH 2 receptor is a G protein coupled receptor selectively activated by PTH . ^^^ We have now generated an antibody from a C terminal peptide sequence of the PTH 2 receptor and used this to study its cellular distribution . ^^^ Labeling with the antibody identified a number of endocrine cells expressing the PTH 2 receptor , including thyroid parafollicular cells , pancreatic islet D cells , and some gastrointestinal peptide synthesizing cells . ^^^ There was complete overlap of PTH 2 receptor labeling with somatostatin in pancreatic islets , and partial overlap with somatostatin in thyroid parafollicular cells and in the gastrointestinal tract . ^^^ These data suggest a broad role for the PTH 2 receptor , especially within the endocrine system , and provide a basis for experimental exploration of its physiology . . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Direct identification of two contact sites for parathyroid hormone ( PTH ) in the novel PTH 2 receptor using photoaffinity cross linking . ^^^ Direct examination of the interacting sites between PTH and the human PTH 2 receptor ( PTH2R ) was conducted by photoaffinity cross linking followed by protein digestion and mapping of the radiolabeled photoconjugated receptor . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Comparison of rat and human parathyroid hormone 2 ( PTH 2 ) receptor activation : PTH is a low potency partial agonist at the rat PTH 2 receptor . ^^^ The human PTH 2 receptor , expressed in tissue culture cells , is selectively activated by PTH . ^^^ The physiological role of the PTH 2 receptor expressed by these cells remains to be determined . ^^^ We have now isolated a complementary DNA including the entire coding sequence of the rat PTH 2 receptor and compared its pharmacological profile with that of the human PTH 2 receptor when each is expressed in COS 7 cells . ^^^ PTH based peptides , including rat PTH ( 1 84 ) , rat PTH ( 1 34 ) , and human PTH ( 1 34 ) , have low potency at the rat PTH 2 receptor for stimulation of adenylyl cyclase ( EC 50 = 19 140 nM ) . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| In particular , the [ Bpa 2 ] and [ Bpa 4 ] substituted analogs selectively antagonized and preferentially cross linked to the PTH 1 receptor and PTH 2 receptor , respectively . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Recent lines of work have led to the identification of constitutively active PTH1Rs in patients with Jansen ' s metaphyseal chondrodysplasia , the demonstration of inverse agonism by certain ligand analogs , and the discovery of the PTH 2 receptor subtype that responds to PTH but not PTHrP . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| N terminal truncation of TIP 39 reverses PTH 2 receptor / PTH1 receptor binding selectivity . ^^^ In this study , we investigated the molecular determinants of both ligand and receptor for the PTH 2 receptor selectivity of TIP 39 and quantitatively evaluated the role of molecular elements in the binding of TIP 39 to the PTH 2 and PTH 1 receptors . ^^^ A chimeric receptor composed of the N terminal extracellular domain of the PTH 1 receptor and the remainder ( juxtamembrane domain ) of the PTH 2 receptor ( P 2 NP1 ) was fully activated by TIP 39 ( E ( max ) = 98 % of the rPTH ( 1 34 ) , E ( max ) , EC ( 50 ) = 2 . 0 nm ) . ^^^ This receptor chimera bound TIP 39 with an equivalent affinity to the wild type PTH 2 receptor ( 2 . 3 and 2 . 0 nm , respectively ) . ^^^ Thus , the juxtamembrane receptor domain specifies the signaling and binding selectivity of TIP 39 for the PTH 2 receptor over the PTH 1 receptor . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Although TIP 39 shares limited sequence homology with parathyroid hormone ( PTH ) , a comparison of the structural features of TIP 39 and PTH illustrates a similar topological display of residues of the N terminal helix important for PTH 2 receptor activation . ^^^ The structural features of TIP 39 , determined in the presence of a zwitterionic lipid to mimic the membrane environment of the G protein coupled PTH 2 receptor , consist of two alpha helices , Ala ( 5 ) Arg ( 21 ) and Leu ( 26 ) Val ( 35 ) . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Tuberoinfundibular peptide of 39 residues ( TIP 39 ) was recently purified from bovine hypothalamus based on selective PTH 2 receptor activation . ^^^ PTH 2 receptor expression is greatest in the CNS , where it is concentrated in limbic , hypothalamic , and sensory areas , especially hypothalamic periventricular neurons , nerve terminals in the median eminence , superficial layers of the spinal cord dorsal horn , and the caudal part of the sensory trigeminal nucleus . ^^^ Thus TIP 39 and PTH 2 receptor influenced functions may range from pituitary and pancreatic hormone release to pain perception . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| We recently identified a novel antagonist , tuberoinfundibular peptide ( 7 39 ) [ TIP ( 7 39 ) ] , derived from the likely endogenous ligand for the PTH 2 receptor TIP 39 . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The tuberoinfundibular peptide TIP 39 [ TIP ( 1 39 ) ] , which exhibits only limited amino acid sequence homology with PTH and PTH related peptide ( PTHrP ) , stimulates cAMP accumulation in cells expressing the PTH 2 receptor ( PTH2R ) , but it is inactive at the PTH / PTHrP receptor ( PTH1R ) . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Synthetic human and mouse TIP 39 showed indistinguishable potencies [ EC ( 50 ) : 0 . 54 ( human ) vs . 0 . 74 nM ( mouse ) ] at the human PTH 2 receptor stably expressed in LLCPK ( 1 ) cells ; furthermore , TIP ( 9 39 ) was an inhibitor of cAMP accumulation stimulated by either [ Tyr ( 34 ) ] PTH ( 1 34 ) amide or human / bovine TIP 39 . ^^^ Because PTH 2 receptor expression was previously shown to be highest in brain , pancreas , and testis , our findings are consistent with the notion that TIP 39 is a neuropeptide which may also have a role in spermatogenesis . . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Transcript expression of the tuberoinfundibular peptide ( TIP ) 39 / PTH2 receptor system and non PTH 1 receptor mediated tonic effects of TIP 39 and other PTH 2 receptor ligands in renal vessels . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Using immunofluorescence confocal microscopy , we demonstrate , for the first time , that RAMPs interact with at least four additional receptors , the VPAC 1 vasoactive intestinal polypeptide / pituitary adenylate cyclase activating peptide receptor with all three RAMPs ; the glucagon and PTH 1 parathyroid hormone receptors with RAMP 2 ; and the PTH 2 receptor with RAMP 3 . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Unlike the PTH 1 receptor , the PTH 2 receptor interacts extremely weakly with parathyroid hormone related peptide ( PTHrP ) . ^^^ The human PTH 2 receptor binds and is activated at high potency by PTH and by the recently discovered peptide tuberoinfundibular peptide of 39 residues ( TIP 39 ) . ^^^ Rat and zebrafish PTH 2 receptors are more weakly activated by PTH , suggesting that TIP 39 may be the natural ligand for the PTH 2 receptor . ^^^ The PTH 2 receptor is strongly coupled to stimulation of cAMP accumulation , and more weakly , in a cell specific manner to increases in intracellular calcium concentration . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| The PTH 2 receptor is activated by TIP 39 but not by PTHrP . ^^^ PTH strongly activates the human PTH 2 receptor but is a weak partial agonist for rat and zebrafish PTH 2 receptors . ^^^ The orientation of receptor ligand interaction is highly similar for PTH and PTHrP binding to the PTH 1 receptor and TIP 39 interaction with the PTH 2 receptor . ^^^ The N interaction provides most of the PTH 1 receptor binding energy for PTH and PTHrP but provides less energy for PTH 2 receptor TIP 39 interaction . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| For the human PTH 2 receptor PTH was a full agonist for increasing cAMP , a partial agonist for increasing [ Ca2+ ] 1 , and bound with high affinity ( 18 nM ) . ^^^ Multiple regions throughout the receptor are required for the PTH PTH 2 receptor complex to adopt a high affinity active state : inserting the rat receptor ' s N terminal domain , EL 1 or EL2 / 3 , into the human receptor increased PTH ' s EC 50 and reciprocal exchanges did not reduce EC 50 . ^^^ These insights should contribute to the development of a high affinity PTH 2 receptor antagonist , for investigating the receptor ' s physiological role . . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| PTH 2 receptor mediated inhibitory effect of parathyroid hormone and TIP 39 on cell proliferation . ^^^ We evaluated the role of the type 2 PTH ( PTH 2 ) receptor on cell proliferation in clonal human embryonic kidney HEK 293 cells stably expressing the human PTH 2 receptor . ^^^ These findings reveal that PTH 2 receptor activation can inhibit cell proliferation and might explain the dual functionality of PTH on cell proliferation . . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| Recently , a new G protein coupled receptor with substantial implications for vascular function the PTH 2 receptor ( PTH 2 R ) has been identified , however , expression and distribution in humans and a possible regulation has not yet been studied . ^^^ We therefore investigated the expression of the PTH 2 receptor on human leukocytes in healthy subjects and in patients with hyperparathyroidism . ^^^ METHODS : PTH 2 receptor expression was quantified by flow cytometry ( FACS ) analysis on monocytes , lymphocytes and granulocytes that were isolated from peripheral blood ( hypotonic density gradient centrifugation ) and by immunohistochemistry using a specific alpha PTH 2 R antibody produced in rabbit . ^^^ RESULTS : Mean relative antigen density of the PTH 2 receptor and percentage of positive cells in healthy subjects was 19 + / 5 and 90 + / 6 % on granulocytes , 5 + / 2 and 55 + / 19 % on monocytes , and 24 + / 7 and 21 + / 7 % on lymphocytes . ^^^ A significant and inverse correlation was found between plasma PTH concentrations and the mean PTH 2 receptor expression on granulocytes ( r = 0 . 41 , p < 0 . 05 ) . ^^^ |
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| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| In fact there is more than one receptor the PTH 2 receptor and a putative carboxy terminal PTH receptor . ^^^ |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49190 and P01270 |
Pubmed |
SVM Score :0.0 |
| NA |
|