| Interacting proteins: P01266 and Q9Y4L1 |
Pubmed |
SVM Score :0.0 |
| Both terminal deoxynucleotidyl transferase mediated biotinylated UTP nick end labeling analysis and immunostaining using anti activated caspase 3 antibody revealed that transgenic mice with targeted neuronal overexpression of ORP 150 ( Tg ORP 150 ) displayed diminished cell death in the Purkinje cell layer and increased numbers of Purkinje cells up to 40 d after birth ( p < 0 . 01 ) , compared with those observed in heterozygous ORP150 / HSP12A deficient ( ORP150+ / ) mice and wild type littermates ( ORP150+ / + ) . ^^^ Cultured Purkinje cells from Tg ORP 150 mice displayed resistance to both hypoxia and AMPA induced stress . ^^^ Behavioral analysis , using rotor rod tasks , indicated impairment of cerebellar function in Tg ORP 150 animals , consistent with the concept that enhanced survival of Purkinje cells results in dysfunction . ^^^ |
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| Interacting proteins: P01266 and Q9Y4L1 |
Pubmed |
SVM Score :0.0 |
| To determine the role of ORP 150 in cerebral infarction following ischemia / reperfusion , ORP 150 transgenic ( TG ) and knockout ( KO ) mice were subjected to 1 or 3 h of middle cerebral artery ( MCA ) occlusion followed by reperfusion for 24 h . ^^^ |
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