| Interacting proteins: P01266 and P07306 |
Pubmed |
SVM Score :0.0 |
| The ability of highly purified 27 , 19 , or 12 S follicular TG to suppress thyroid restricted gene expression correlates with their ability to bind to FRTL 5 thyrocytes and is inhibited by a specific antibody to the thyroid apical membrane asialoglycoprotein receptor ( ASGPR ) , which is related to the ASGPR of liver cells . ^^^ Phosphorylating serine / threonine residues of TG , by autophosphorylation or protein kinase A , eliminates TG suppression and enhances transcript levels of the thyroid restricted genes 2 fold in the absence of a change in TG binding to the ASGPR . ^^^ |
|
| Interacting proteins: P01266 and P07306 |
Pubmed |
SVM Score :0.0 |
| Here we show that PC Cl 3 cells , a differentiated rat thyroid cell line , bound thyroglobulin ( Tg ) via ASGPr . ^^^ |
|
| Interacting proteins: P01266 and P07306 |
Pubmed |
SVM Score :0.0 |
| Moreover , albeit its expression in thyroid is less abundant than in liver , the receptor is able to bind asialorosomucoid ( ASOR ) , the best known ligand of hepatic ASGPr , and to mediate endocytosis of a significative amount of Tg on the surface of differentiated PC Cl 3 thyroid cells . ^^^ |
|
| Interacting proteins: P01266 and P07306 |
Pubmed |
SVM Score :0.0 |
| NA |
|