| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.58739326 |
| A mature , fully glycosylated , form of CRLR was associated with ( 125 ) 1 CGRP binding , upon co expression of RAMP 1 and CRLR . 0.58739326^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.5455023 |
| These data strongly support CRLR , together with appropriate RAMPs as binding sites for CGRP and adrenomedullin in cultured cells . . 0.5455023^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.8202355 |
| It has been shown that the complex between calcitonin receptor like receptor ( CRLR or CL ) and receptor activity modifying protein ( RAMP ) 1 provides a molecular correlate for the CGRP ( 1 ) receptor ; however , this does not explain the range of affinities seen for CGRP ( 8 37 ) in isolated tissues . 0.8202355^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The CRLR was thought to be a calcitonin gene related peptide ( CGRP ) type 1 receptor ( Aiyar et al . , J . ^^^ This contrasts with previously reported evidence that the CRLR is an orphan receptor with no identifiable interactions with CGRP and other related ligands ( Flhmann et al . , Biochem . ^^^ The different regional distribution of CGRP receptor binding sites and CRLR mRNA implies the latter encoding a different CGRP receptor subtype . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Collectively , the binding and functional data demonstrate that we have cloned a porcine CGRP type 1 receptor . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Here we show that a receptor with seven transmembrane domains , the calcitonin receptor like receptor ( CRLR ) , can function as either a CGRP receptor or an adrenomedullin receptor , depending on which members of a new family of single transmembrane domain proteins , which we have called receptor activity modifying proteins or RAMPs , are expressed . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Using in situ hybridisation , we demonstrate the heterogenous distribution of the mRNAs of two proposed CGRP 1 receptors ( RDC 1 and calcitonin receptor like receptor , CRLR ) in the rat brain . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Intact rat heart expressed mRNA encoding the putative AM / CGRP receptors RDC 1 and CRLR at 37 and 15 fold higher levels , respectively , than the AM selective receptor L 1 , with a qualitatively similar profile in cultured neonatal cardiac myocytes . ^^^ The high level of expression of RDC 1 and CRLR suggests that both AM and CGRP may have direct actions on the cardiac myocyte via common receptors that can interact with either ligand . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Swiss 3T3 cell lines were constructed co expressing receptor activity modifying protein ( RAMP ) 1 with the calcitonin receptor like receptor ( CRLR ) , and showed 125I calcitonin gene related peptide ( CGRP ) 1 binding indicative of a type 1 CGRP receptor . ^^^ This potassium current was increased following CGRP application or co expression of CRLR , but decreased by PTX or co expression of transducin . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| In conclusion , the recognition of RAMP 1 and 2 as mediators of CRLR expression as a CGRP or ADM receptor has been extended , with evidence that endogenous RAMP 2 is sufficient to reveal an ADM receptor in UMR 106 cells . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The calcitonin receptor like receptor ( CRLR ) can function as either a receptor for calcitonin gene related peptide ( CGRP ) or for adrenomedullin ( ADM ) , depending upon the coexpression of a novel family of single transmembrane proteins , which we have called receptor activity modifying proteins or RAMPs . ^^^ RAMPs 1 , 2 , and 3 transport CRLR to the plasma membrane with similar efficiencies , however RAMP 1 presents CRLR as a terminally glycosylated , mature glycoprotein and a CGRP receptor , whereas RAMPs 2 and 3 present CRLR as an immature , core glycosylated ADM receptor . ^^^ Coexpression of RAMP2 / 1 with CRLR formed a core glycosylated ADM receptor , whereas the RAMP1 / 2 chimera generated both core glycosylated and mature forms of CRLR and enabled both ADM and CGRP receptor binding . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| RAMP 1 transported CRLR is a calcitonin gene related peptide ( CGRP ) receptor . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| RDC 1 and CRLR in the presence of particular modifying proteins can also bind calcitonin gene related peptide ( CGRP ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Calcitonin ( CT ) , calcitonin gene related peptide ( CGRP ) , amylin , and adrenomedullin constitute a family of structurally related peptides that signal via either the calcitonin receptor like receptor or the CT receptor , with receptor phenotype determined by coexpression of one of the three receptor activity modifying proteins ( RAMPs ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| To support the suggestion of a possible link between the pharmacological actions of alpha and beta CGRP and a specific receptor , we wished to determine whether mRNAs required for the expression of calcitonin receptor like receptor ( CRLR ) derived CGRP receptors were present in the guinea pig basilar artery . ^^^ Equipotent in vitro actions of alpha and beta CGRP on guinea pig basilar artery are likely to be mediated via CRLR derived CGRP receptors . ^^^ The presence of mRNA encoding the guinea pig CRLR and the guinea pig CGRP receptor component protein ( RCP ) in the guinea pig basilar artery was demonstrated by RT PCR methods . ^^^ The expression in this tissue of a CRLR derived CGRP receptor and a functional RCP is therefore likely , and the equipotent pharmacological actions of alpha and beta CGRP might be mediated via CRLR derived CGRP receptors . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Differential glycosylation of human and rat ( r ) calcitonin ( CT ) receptor like receptors ( CRLR ) as a result of interactions with accessory receptor activity modifying proteins ( RAMP ) 1 or 2 was considered to define CT gene related peptide ( CGRP ) or adrenomedullin ( ADM ) receptors in mammalian cells . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| This contrast may be explained by the in vivo impregnation of major hormones , so we have tested if glucocorticoids were able in vitro to enhance the expression of the RAMP1 / CRLR expression leading to functional CGRP receptors . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| CGRP and adrenomedullin binding correlates with transcript levels for calcitonin receptor like receptor ( CRLR ) and receptor activity modifying proteins ( RAMPs ) in rat tissues . 1 . ^^^ Calcitonin Receptor Like Receptor ( CRLR ) , in combination with Receptor Activity Modifying Proteins ( RAMPs ) is hypothesized to bind either CGRP or adrenomedullin . ^^^ Calcitonin Receptor Like Receptor ( CRLR ) , in combination with Receptor Activity Modifying Proteins ( RAMPs ) is hypothesized to bind either CGRP or adrenomedullin . ^^^ In this study it is shown that rat CRLR cDNA specifies a CGRP receptor when co transfected with RAMP 1 cDNA and an adrenomedullin receptor when co transfected with either RAMP 2 or RAMP 3 cDNA in human embryonic kidney 293 cells . 3 . ^^^ CRLR , RAMP , RCD 1 and L 1 mRNA levels and CGRP and adrenomedullin receptor densities have been measured and correlated with each other in eight rat tissues selected for their distinctive patterns of CGRP and adrenomedullin binding . 4 . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| A candidate CGRP receptor named calcitonin receptor like receptor ( CRLR ) has been identified , and in this study RCP co immunoprecipitated with CRLR indicating that these two proteins interact directly . ^^^ Since CGRP and adrenomedullin can both signal through CRLR , which has been previously shown to require a chaperone protein for function , we now propose that a functional CGRP or adrenomedullin receptor consists of at least three proteins : the receptor ( CRLR ) , the chaperone protein ( RAMP ) , and RCP that couples the receptor to the cellular signal transduction pathway . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The displacing potencies of CGRP and CGRP [ 8 37 ] were very weak . mRNAs for AM as well as calcitonin receptor like receptor and receptor activity modifying protein 2 which form a receptor specific to AM , were highly expressed in the microvessels . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The calcitonin receptor like receptor ( CRLR ) and the orphan receptor RDC 1 have been proposed as CGRP 1 receptors , and recent evidence suggests that CRLR can function as either a CGRP 1 receptor or an adrenomedullin ( ADM ) receptor . ^^^ Receptor activity modifying proteins ( RAMPs ) determine the ligand specificity of CRLR : coexpression of CRLR and RAMP 1 results in a CGRP 1 receptor , whereas coexpression of CRLR and RAMP 2 or 3 results in an ADM receptor . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| We recently detected the mRNA encoding for RAMP 2 , CRLR , and the CGRP receptor RDC 1 in rat lung . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| This study looked for the effect of CGRP and the antagonist CGRP 8 37 , specific for CGRP type 1 receptor , 1 ) on GI motility ( interdigestive and postprandial ) , and 2 ) on hemodynamy , in conscious dogs . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| In conclusion , functional CGRP ( 1 ) and CGRP ( 2 ) receptors may mediate a positive inotropic effect at both the atrial and ventricular level of the human heart . mRNAs for calcitonin receptor like receptor and specific RAMPs further support the presence of CGRP receptors . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The calcitonin receptor like receptor ( CRLR ) requires novel receptor activity modifying proteins ( RAMPs ) for its function as an adrenomedullin ( ADM ) or a calcitonin ( CT ) gene related peptide ( CGRP ) receptor . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Expression of the calcitonin receptor like receptor ( CRLR ) and its receptor activity modifying proteins ( RAMPs ) can produce calcitonin gene related peptide ( CGRP ) receptors ( CRLR / RAMP1 ) and adrenomedullin ( AM ) receptors ( CRLR / RAMP2 or 3 ) . ^^^ CRLR GFP failed to generate responses to CGRP or AM without RAMPs . ^^^ Agonist mediated internalization of CRLR GFP was observed in RAMP1 / CGRP or AM , RAMP2 / AM , and RAMP3 / AM , which occurred with similar kinetics , indicating the existence of ligand specific regulation of CRLR internalization by RAMPs . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| In bronchial blood vessels CGRPR 1 immunoreactivity was detected in the endothelium of the venules and not in the arterioles , which is particularly relevant for elucidating the putative role of CGRP in inflammation in this tissue . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Calcitonin receptor like receptor ( CRLR ) constitutes either a CGRP receptor when complexed with receptor activity modifying protein 1 ( RAMP 1 ) or an adrenomedullin receptor when complexed with RAMP 2 or RAMP 3 . ^^^ Similarly , in HEK 293 EBNA cells constitutively expressing RAMP1 / CRLR receptor complex CGRP binding was remarkably inhibited . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The calcitonin receptor like receptor ( CRLR ) can function as a receptor for either calcitonin gene related peptide ( CGRP ) or adrenomedullin ( AM ) , depending upon co expression with members of a novel family of receptor activity modifying proteins ( RAMP ) . ^^^ RAMP 1 presents the CRLR at the cell surface as a CGRP / AM receptor . ^^^ The pattern of differential and cell specific expression of CRLR and RAMP suggests the involvement of CRLR / RAMP1 in the processes of vasodilation , smooth muscle relaxation and angiogenesis in response to AM and CGRP in the human uterus , but also indicates that other receptors may be implicated . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The calcitonin receptor like receptor ( CRLR ) is a seven transmembrane domain ( 7TM ) protein that requires the receptor activity modifying protein 1 ( RAMP 1 ) to be expressed at the cell surface as a functional calcitonin gene related peptide ( CGRP ) receptor . ^^^ CGRP binding and receptor activation lead to the phosphorylation of CRLR and the internalization of the receptor as a stable complex . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| It has recently been shown that the molecular pharmacology of CGRP and ADM is determined by coexpression of one of three receptor activity modifying proteins ( RAMPs ) with calcitonin receptor like receptor ( CRLR ) . ^^^ As expected CRLR RAMP 1 coexpression conferred sensitivity to CGRP , whilst association of RAMP 2 or RAMP 3 with CRLR conferred high affinity ADM binding . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| CRLR may function as a calcitonin gene related peptide ( CGRP ) or a selective ADM receptor depending on the expression of the subtype 1 or the subtypes 2 and 3 of a family of proteins , referred to as receptor activity modifying proteins ( RAMPs ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Calcitonin gene related peptide ( CGRP ) and adrenomedullin ( ADM ) , two closely related peptides , initiate their biological responses through their interaction with calcitonin receptor like receptor ( CRLR ) . ^^^ Characterization of RAMP1 / human or porcine CRLR combination by radioligand binding ( [ 125I ] halphaCGRP ) and functional assay ( activation of adenylyl cyclase ) revealed the properties of CGRP receptor . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the AM mediated induction of CRE luciferase activity was abolished by coincubation with the receptor antagonist CGRP ( 8 37 ) or by overexpression of a CRLR antisense construct . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Messenger RNA analysis of the candidate genes for CGRP and adrenomedullin receptors revealed an abundance of both CRLR and RAMP 1 mRNA , suggesting that these genes encode one of the CGRP receptors in this tissue . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| This study aimed to identify the cellular location of calcitonin receptor like receptor ( CRLR ) which is pharmacologically identical to CGRP receptor 1 , a putative molecular target of CGRP and adrenomedullin . ^^^ Extensive and specific CRLR immunostaining was detected in arteriolar smooth muscle and venular endothelium and is consistent with CGRP ' s putative role in neurogenic inflammation . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Recent researches suggest that adrenomedullin ( ADM ) and calcitonin gene related peptide ( CGRP ) bind to the same calcitonin receptor like receptors ( CRLR ) , with receptor specificity being determined by a receptor activity modifying protein ( RAMP ) . ^^^ Our objective was to explore the significance of CRLR / RAMP hypothesis in cardiovascular tissues through experiments on the phenomenon of desensitization of both ADM and CGRP receptors using cultured rat aortic vascular smooth muscle cells ( VSMCs ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| This effect was not blocked by co treatment with the CGRP type 1 receptor antagonist CGRP ( 8 37 ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The heterodimeric CGRP receptor requires co expression of calcitonin receptor like receptor ( CRLR ) and an accessory protein called receptor activity modifying protein ( RAMP ) 1 ( McLatchie , L . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Co expression of CRLR with RAMP 1 or 2 revealed CGRP or AM receptors , respectively . ^^^ There , heterodimeric complexes between CRLR or CTR and the corresponding RAMP reveal high affinity receptors for AM , CGRP , and amylin . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| A notable example of heteromer formation is the interaction of the calcitonin receptor like receptor ( CRLR ) with different members of the receptor activity modifying protein ( RAMP ) family , which results in the formation of two different receptors , a calcitonin gene related peptide ( CGRP ) receptor and an adrenomedullin receptor . ^^^ Co expression of RAMP 1 and CRLR reconstituted a CGRP receptor that was able to activate the pheromone signaling pathway with pharmacological properties similar to those observed previously in mammalian cells . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| In this review we have focused on the proposition that the calcitonin receptor like receptor ( CRLR ) is a receptor both for AM and the related vasoactive peptide calcitonin gene related peptide ( CGRP ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The discovery of receptor activity modifying proteins ( RAMP ) 1 and 2 and their co expression with an orphan receptor , calcitonin receptor like receptor ( CRLR ) has led to the elucidation of functional CGRP and AM receptors , respectively . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Receptor activity modifying proteins ( RAMPs ) determine the ligand specificity of the calcitonin receptor like receptor ( CRLR ) ; co expression of RAMP 1 and CRLR results in a CGRP receptor , whereas the association of RAMP 2 or RAMP 3 with CRLR gives an ADM receptor . ^^^ The present results suggested after congestive heart failure in adult rats , an up regulation of the CGRP receptor ( by an increase in RAMP 1 that is associated with CRLR ) in atria and ventricles and of ADM receptor ( by increased RAMP 3 expression that is associated with CRLR ) in atria . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| It was recently reported that the CGRP receptor is formed when a calcitonin receptor like receptor ( CRLR ) and receptor activity modifying protein ( RAMP ) 1 are co expressed on the cell membrane . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| In this study , we cloned mouse cDNA counterparts of the human CGRP receptor composed of calcitonin receptor like receptor ( CRLR ) and receptor activity modifying protein 1 ( RAMP 1 ) and examined the signal transduction mechanism through the CGRP receptor . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| It can discriminate between the CRLR / RAMP1 receptor expressed on SK N MC cells and the CGRP responsive receptor expressed by the Col 29 cells used in this study . ^^^ At concentrations of up to 10 micro M , it has no antagonist actions at the adrenomedullin , CRLR / RAMP2 receptor , unlike CGRP ( 8 37 ) . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| CGRP ( 1 ) receptors are represented by CRLR and RAMP 1 , and specific adrenomedullin receptors by CRLR and RAMP 2 or 3 . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The receptor for calcitonin gene related peptide ( CGRP ) is a heterodimer formed by calcitonin receptor like receptor ( CRLR ) , a type 2 ( family B ) G protein coupled receptor , and receptor activity modifying protein 1 ( RAMP 1 ) , a single membrane pass protein . ^^^ It is likely that the first seven or so amino acids of CGRP ( which form a disulphide bonded loop ) interact with the transmembrane domain of CRLR to cause receptor activation . ^^^ It is likely that these regions of CGRP interact both with CRLR and with the extracellular domain of RAMP1 . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| RESULTS : mRNA transcripts for the cell surface CGRP receptor subunits receptor activity modifying protein 1 ( RAMP 1 ) and calcitonin receptor like receptor ( CRLR ) as well as for the intracellular adapter protein CGRP receptor component protein ( CGRP RCP ) were found in CD 34 ( + ) cells from 4 / 4 donors tested . ^^^ CGRP RCP mRNA was expressed in peripheral blood granulocytes of 8 / 15 donors , whereas RAMP 1 and CRLR were not detectable . ^^^ Both RAMP 1 and CRLR mRNA expression and CGRP receptor signaling capacity were lost during in vitro granulocytic differentiation of CD 34 ( + ) cells . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| While L 1 R is selective for ADM , CRLR may bind either calcitonin gene related peptide ( CGRP ) or ADM depending on the expression of the subtype 1 or the subtypes 2 and 3 of a family of chaperones , named receptor activity modifying proteins ( RAMPs ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| There appear to be two receptors for CGRP : the CGRP A receptor , a well characterized receptor consisting of calcitonin receptor like receptor and receptor activity modifying protein 1 , and the CGRP B receptor . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Functional CGRP 1 receptors appear to consist of at least three different kinds of proteins : the calcitonin receptor like receptor ( CRLR ) , receptor activity modifying proteins ( RAMPs ) and the receptor component protein ( RCP ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The initially orphan calcitonin receptor like receptor ( CRLR ) was identified as a CGRP receptor when coexpressed with RAMP 1 . ^^^ Thus , two Class 2 G protein coupled receptors , the CRLR and CTR , associate with three RAMP to form high affinity receptors for CGRP , ADM , or amylin . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| CRLR , initially classed as an orphan receptor , is a CGRP receptor when co expressed with RAMP 1 . ^^^ Together with human RAMP 3 , CRLR defines an AM receptor , and with mouse RAMP 3 it is a low affinity CGRP / AM receptor . ^^^ CTR RAMP 1 , antagonized preferentially by salmon CT ( 8 32 ) and not by CGRP ( 8 37 ) , and CRLR RAMP 1 , antagonized by CGRP ( 8 37 ) , are two CGRP receptor isotypes . ^^^ Thus amylin and CGRP interact specifically with heterodimeric complexes between CTR and RAMP 1 or RAMP 3 , and CGRP and AM interact with complexes between CRLR and RAMP 1 , RAMP 2 or RAMP3 . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| RCP works in conjunction with two other proteins to constitute a functional CGRP receptor : calcitonin receptor like receptor ( CRLR ) and receptor activity modifying protein 1 ( RAMP 1 ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Three receptor activity modifying proteins ( RAMP ) define specific interactions between calcitonin ( CT ) gene related peptide ( CGRP ) , adrenomedullin ( AM ) and amylin , and a CT receptor or a CT receptor like receptor ( CRLR ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| We report here on the characterization and immunohistochemical localization in human tissues of calcitonin receptor like receptor ( CRLR ) which was recently found to mediate the effects of both calcitonin gene related peptide ( CGRP ) and adrenomedullin ( ADM ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The calcitonin gene related peptide ( CGRP ) receptor and adrenomedullin ( ADM ) receptor are generated by the concomitant expression of a calcitonin receptor like receptor ( CL receptor ) and a specific receptor activity modifying protein ( RAMP ) in mammals . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| A functional calcitonin gene related peptide ( CGRP ) receptor requires dimerization of calcitonin receptor like receptor ( CRLR ) with receptor activity modifying protein 1 ( RAMP 1 ) . ^^^ These RAMP 1 mutants were examined for their ability to associate with CRLR to effect CGRP stimulated cAMP accumulation , CGRP binding , CRLR trafficking , and cell surface expression . ^^^ All RAMP 1 mutants were able to associate with CRLR with full efficacy for CGRP stimulated cAMP accumulation . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| A monoclonal antibody to cerebellar CGRP receptors specifically detects a 66 kDa protein from rat cerebellum and other rat and human tissues , but not from SK N MC cells which express calcitonin receptor like receptor ( CRLR ) , a recently described component of CGRP receptors . ^^^ Evidence for the existence of a new receptor for CGRP , which is not CRLR . ^^^ Furthermore , the antibody could not detect any immunoreactive protein in HEK 293 cells transiently transfected with CRLR and receptor activity modifying protein 1 ( RAMP ( 1 ) ) indicating the possible existence of another CGRP receptor , which does not involve CRLR . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| RT PCR was employed for the detection of mRNA of rat calcitonin receptor like receptor ( CRLR ) , which is considered to represent the pharmacologically defined CGRP receptor 1 subtype , as well as mRNA of the receptor activity modifying proteins , which are essential for CRLR function and determine ligand specificity . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| These data suggest that adrenomedullin might stimulate histamine release via its proposed receptor ( CRLR / RAMP2 or 3 ) , rather than via the CGRP receptor ( CRLR / RAMP1 ) . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| RAMP 1 is an accessory protein for another putative CGRP receptor , calcitonin receptor like receptor . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Among them , AM and CGRP are reported to share a core receptor , the calcitonin receptor like receptor ( CRLR ) , and the specificity of the CRLR is determined by the expression levels of receptor activity modifying proteins ( RAMPs ) . ^^^ The specificity of CRLR was clearly determined by the expression of RAMPs ; RAMP 1 converted CRLR to CGRP receptor , while RAMP 2 and RAMP 3 converted it to AM receptor , but the affinity of CTR for AMY was not increased by the expression of any known RAMPs . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Expression of components of the CGRP receptor , calcitonin receptor like receptor ( CRLR ) and receptor activity modifying protein 1 ( RAMP 1 ) , was determined by the use of Western blot analysis . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Recently , receptor activity modifying proteins ( RAMPs ) have been shown to transport calcitonin receptor like receptor ( CRLR ) to the cell surface to present either as CGRP receptor or adrenomedullin receptor . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| CRLR functions as either a calcitonin gene related peptide ( CGRP ) receptor or a selective AM receptor depending on which member of a family of receptor activity modifying proteins ( RAMPs ) is expressed : RAMP 1 generates CGRP receptors , while RAMP 2 and RAMP 3 produce AM receptors . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| When co expressed with receptor activity modifying protein ( RAMP ) 1 , calcitonin receptor like receptor ( CRLR ) can function as a receptor for both calcitonin gene related peptide ( CGRP ) and adrenomedullin ( AM ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Here we show that the CGRP binding protein referred to as the calcitonin receptor like receptor is highly concentrated at the avian neuromuscular junction together with its two accessory proteins , receptor activity modifying protein 1 and CGRP receptor component protein , required for ligand specificity and signal transduction . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Calcitonin receptor like receptor ( CRLR ) , a seven domain transmembrane protein functions as CGRP A receptor , in association with receptor activity modifying protein ( RAMP ) 1 , a single domain transmembrane protein , whereas CRLR and RAMP 2 or RAMP 3 constitute a receptor for AM . ^^^ Calcitonin receptor like receptor ( CRLR ) , a seven domain transmembrane protein functions as CGRP A receptor , in association with receptor activity modifying protein ( RAMP ) 1 , a single domain transmembrane protein , whereas CRLR and RAMP 2 or RAMP 3 constitute a receptor for AM . ^^^ In the present investigation , we examined the mRNA expression of CRLR , RAMP 1 , RAMP 2 , and RAMP 3 in rat uterus ( n = 8 ) by reverse transcriptional analysis and polymerase chain reaction to assess the changes in the expression of CGRP A and AM receptor components during pregnancy and labor and by steroid hormone treatments in adult ovariectomized rats . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The present study was aimed to investigate mRNA expression of CGRP A receptor components , calcitonin receptor like receptor ( CRLR ) and receptor activity modifying protein 1 ( RAMP ( 1 ) ) in the rat placenta . ^^^ Elevated placental CRLR and RAMP ( 1 ) may be involved in CGRP related increases in blood flow and therefore fetal growth and decreases at term labour may help minimize the blood loss . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| We also hypothesized that the expression of CGRP A receptor components , calcitonin receptor like receptor ( CRLR ) , receptor activity modifying protein ( RAMP 1 ) , and CGRP B receptors are greater in pregnant rats . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Adrenomedullin ( AM ) has two known receptors formed by the calcitonin receptor like receptor ( CL ) and receptor activity modifying protein ( RAMP ) 2 or 3 : we report the effects of the antagonist fragments of human AM and CGRP ( AM 22 52 and CGRP 8 37 ) in inhibiting AM at human ( h ) , rat ( r ) and mixed species CL / RAMP2 and CL / RAMP3 receptors transiently expressed in Cos 7 cells or endogenously expressed as rCL / rRAMP2 complexes by Rat 2 and L 6 cells . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| CGRP receptor belongs to the calcitonin receptor like receptor ( CRLR ) family of G protein coupled receptors and has been shown to require a single transmembrane domain protein called receptor activity modifying protein 1 ( RAMP 1 ) for its functional expression as well as activity . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| In contrast to CGRP and ADM , which exhibited a preferential stimulation of CRLR when co expressed with RAMP 1 and RAMP 2 or RAMP 3 , respectively , intermedin represents a nonselective agonist for the RAMP coreceptors . ^^^ Thus , identification of intermedin as a novel member of the calcitonin / CGRP peptide family capable of signaling through CRLR / RAMP receptor complexes provides an additional player in the regulation of peripheral tissues by CRLR and will allow development of new therapeutic agents for pathologies associated with diverse vascular and gastrointestinal disorders . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The purpose of the present study was to characterize the effects of human ( h ) alpha and beta calcitonin gene related peptide ( CGRP ) on intracranial arteries from man and to investigate the presence of mRNA for the calcitonin receptor like receptor ( CRLR ) and the receptor activity modifying proteins ( RAMPs ) 1 , 2 and 3 , in cerebral and middle meningeal arteries with and without endothelium , in microvessels and in the endothelial cells isolated from the human basilar artery . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The CGRP A receptor consists of calcitonin receptor like receptor ( CRLR ) and receptor activity modifying protein 1 ( RAMP 1 ) ; however , the CGRP B receptor needs to be further characterized . ^^^ Messenger RNA levels for CRLR and RAMP 1 were assessed by reverse transcription polymerase chain reaction , and CGRP B receptor proteins levels were determined by Western blot analysis . ^^^ Both mRNA for CGRP A ( CRLR and RAMP 1 ) and the protein for CGRP B receptors in mesenteric arteries were increased with pregnancy compared to nonpregnant , diestrous animals . ^^^ In adult ovariectomized rats , P 4 upregulated CRLR and RAMP 1 mRNA levels as well as [ 125I ] CGRP binding sites . ^^^ Together with earlier findings , these data suggest that increases in the expression of CGRP A ( CRLR and RAMP 1 ) and CGRP B receptors in mesenteric arteries may be important in reducing vascular resistance and in vascular adaptations that occur during pregnancy ; in addition , P 4 may be involved in this process . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The present study was designed to examine the existence of CGRP A receptor components , the calcitonin receptor like receptor ( CRLR ) and receptor activity modifying protein 1 ( RAMP 1 ) , in the human placenta and the vasoactivity of CGRP in the fetoplacental circulation . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| CGRP , AMY and AM receptors are complexes which include a GPCR ( the CT receptor or CTR and calcitonin receptor like receptor or CRLR ) and a single transmembrane domain protein known as receptor activity modifying proteins ( RAMPs ) as well as an intracellular protein named receptor component protein ( RCP ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Recently , receptor activity modifying proteins ( RAMPs ) have been shown to transport calcitonin receptor like receptor ( CRLR ) to the cell surface to present either as CGRP receptor or ADM receptor . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Therefore , we examined whether mRNAs encoding CGRP or ADM receptor subunit , RDC 1 , calcitonin receptor like receptor ( CRLR ) , and receptor activity modifying proteins ( RAMPs ) are present , and if so , whether their expression is modified by IgE receptor triggering , in a mucosal type mast cell line , rat basophilic leukemia ( RBL 2H3 ) cells using RT PCR . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The calcitonin receptor like receptor ( CRLR ) and the orphan receptor RDC 1 have been proposed to be calcitonin gene related peptide type 1 ( CGRP 1 ) receptors , and receptor activity modifying proteins ( RAMPs ) determine the ligand specificity of CRLR . ^^^ Coexpression of RAMP 1 and CRLR resulted in functional CGRP 1 receptors ; the complex of RAMP 2 or RAMP 3 and CRLR created functional adrenomedullin receptor . ^^^ In the present study , we used real time quantitative RT PCR to detect and quantitate the relative expression of CGRP , CRLR , RAMP 1 3 and RDC 1 in the nucleus accumbens of intact rats and rats with inflammation . ^^^ Our results demonstrate that CGRP , CRLR , RAMP 1 and RAMP 2 exist in the nucleus accumbens of intact rats , and that they were significantly upregulated in rats with inflammation . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| CGRP receptors are observed in presence of the RAMP1 / calcitonin receptor like receptor ( CRLR ) , but the association of RAMP 2 or RAMP 3 with CRLR generates an adrenomedullin receptor . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| In the rat uterine artery , two types of CGRP receptors have been shown to coexist , CGRP A receptor , which is a complex of calcitonin receptor like receptor ( CRLR ) , and receptor activity modifying protein ( RAMP ( 1 ) ) and CGRP B receptor , which is different from CRLR . ^^^ In the present study , we hypothesized that : 1 ) CGRP induced vasorelaxation in rat uterine artery is mediated through CGRP A receptor and 2 ) N terminal ( Nt ) domain of CRLR ( Nt CRLR ) has a major contribution in ligand binding and mediating CGRP induced relaxation effects in rat uterine artery . ^^^ Polyclonal antibodies against Nt domain of CRLR and RAMP ( 1 ) ( Nt RAMP ( 1 ) ) were raised in rabbits and characterized for their specificity and were used to inhibit CGRP induced vasorelaxation in rat uterine artery . ^^^ These studies suggest that CGRP effects in rat uterine artery are mediated through CGRP A receptor and that Nt domain of CRLR may play a predominant role in CGRP binding and thus in causing CGRP induced uterine artery relaxation . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Calcitonin receptor like receptor ( CRLR ) is a seven transmembrane ( 7 TM ) domain class B G protein coupled receptor ( GPCR ) which requires coexpression of different receptor activity modifying proteins ( RAMP ) to become a functional calcitonin gene related peptide ( CGRP ) receptor or an adrenomedullin ( AM ) receptor . ^^^ Calcitonin receptor like receptor ( CRLR ) is a seven transmembrane ( 7 TM ) domain class B G protein coupled receptor ( GPCR ) which requires coexpression of different receptor activity modifying proteins ( RAMP ) to become a functional calcitonin gene related peptide ( CGRP ) receptor or an adrenomedullin ( AM ) receptor . ^^^ The ability of Nt CRLR to bind CGRP and AM independent of RAMPs was determined by studying inhibition of ( 125 ) 1 CGRP and ( 125 ) 1 AM binding to pregnant rat uterine membrane in the presence of Nt CRLR protein . ^^^ We observe that Nt CRLR inhibits ( 125 ) 1 CGRP and ( 125 ) 1 AM binding to rat uterus in a dose dependent fashion ( IC ( 50 ) = 0 . 25 and 0 . 29 muM , respectively ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| ELT 3 cells expressed CGRP and AM receptor components CRLR , RAMP 1 , RAMP 2 , and RAMP 3 . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| AM 2 increased cAMP accumulation in cells expressing human CT receptor like receptor ( CRLR ) and one of receptor activity modifying proteins ( RAMPs ) , but it was no more potent than CGRP and AM . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Using reverse transcriptase polymerase chain reaction ( RT PCR ) , the presence of mRNA sequences encoding the calcitonin receptor like receptor , receptor activity modifying protein ( RAMP 1 , RAMP 2 , RAMP 3 ) and receptor component protein were demonstrated in human subcutaneous arteries , indicating the presence of CGRP ( 1 ) like receptor and the necessary component for the receptor activation . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Adrenomedullin and CGRP are two potent vasodilator peptides , and their receptors are formed by heterodimerization of the CRLR and a RAMP molecule . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The present study was designed to investigate the expression of CGRP receptor components , calcitonin receptor like receptor ( CRLR ) , and receptor activity modifying protein 1 ( RAMP 1 ) , and the relaxation response to CGRP in fetoplacental vessels from normotensive pregnant women and women with preeclampsia . ^^^ In contrast , both vascular tissues and trophoblasts showed decreased expressions for CRLR and RAMP 1 proteins and declined CGRP binding sites in preeclamptic placentas ; and 3 ) CGRP produced a dose dependent relaxation of serotonin induced contraction of umbilical and chorionic arteries from normal pregnancies , but the response to CGRP was significantly attenuated in the vessels from preeclampsia . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| We performed a mutation screening by PCR exon amplification , single strand conformation polymorphism ( SSCP ) and sequencing in four candidate genes , CgRPs ( alphaCgRP , betaCgRP ) , their receptor ( CgRPR ) and the receptor component protein ( CgRP RCP ) , in 90 selected cases of idiopathic unilateral or bilateral cryptorchidism . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Western blots showed that calcitonin receptor like receptor ( CRLR ) and receptor activity modifying protein 1 ( RAMP 1 ) , which constitute a CGRP receptor , were significantly upregulated in mesenteric arteries in the Ang 2 group compared to the other three groups ( P < 0 . 05 ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The calcitonin receptor like receptor ( CLR ) requires the associated receptor activity modifying protein ( RAMP ) 1 to reveal a calcitonin gene related peptide ( CGRP ) receptor . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Calcitonin gene related peptide ( CGRP ) is a vasorelaxant and positive inotropic and chronotropic peptide that binds to the calcitonin receptor like receptor . ^^^ Four , 8 , and 16 weeks thereafter cardiac CGRP content ( radioimmunoassay ) , calcitonin receptor like receptor expression ( by real time RT PCR ) , and CGRP and calcitonin receptor like receptor tissue distribution ( immunohistochemistry ) were assessed . ^^^ Since sensory neurons have been reported to decrease expression of the CGRP precursor in the course of diabetes , the intra axonal accumulation of CGRP observed here reflects impaired release , which , coupled with the down regulation of its cognate receptor , calcitonin receptor like receptor , may contribute to the well documented impairment of cardioprotective functions in diabetes . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Calcitonin gene related peptide ( CGRP ) is clearly an anabolic factor in skeletal tissue , but the distribution of CGRP receptor ( CGRPR ) subtypes in osteoblastic cells is poorly understood . ^^^ The aim of the present study was to further characterize the MG 63 CGRPR using a selective agonist of the putative CGRPR 2 , [ Cys ( Acm ) ( 2 , 7 ) ] CGRP , and a relatively specific antagonist of CGRPR 1 , CGRP ( 8 37 ) . [ Cys ( Acm ) ( 2 , 7 ) ] CGRP acted as a significant agonist only upon ERK dephosphorylation , whereas this analog effectively antagonized CGRP induced cAMP production and phosphorylation of cAMP response element binding protein ( CREB ) and p 38 MAPK . ^^^ Considering previous data from Scatchard analysis of [ 125I ] CGRP binding in connection with these results , these findings suggest that MG 63 cells possess two functionally distinct CGRPR subtypes that show almost identical affinity for CGRP but different sensitivity to CGRP analogs : one is best characterized as a variation of CGRPR 1 , and the second may be a novel variant of CGRPR2 . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The calcitonin receptor like receptor ( CRLR ) will not reach the cell surface without any one of the three RAMP proteins to function as either a CGRP or adrenomedullin receptor . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| These cells express mRNA for CGRP receptor components , calcitonin receptor like receptor , and receptor activity modifying protein 1 . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Calcitonin receptor like receptor ( CLR ) and receptor activity modifying protein 1 ( RAMP 1 ) comprise a receptor for calcitonin gene related peptide ( CGRP ) and intermedin . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : We analysed the effect of aldosterone on calcitonin gene related peptide ( CGRP ) mediated vasodilation in noradrenaline precontracted endothelium denuded mesenteric arteries segments from Wistar Kyoto rats ( WKY ) and spontaneously hypertensive rats ( SHR ) and the effect of aldosterone on calcitonin receptor like receptor ( CL receptor ) and receptor activity modifying protein 1 ( RAMP 1 ) expression in endothelium denuded mesenteric arteries from SHR rats . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Adrenomedullin and CGRP interact with endogenous calcitonin receptor like receptor in endothelial cells and induce its desensitisation by different mechanisms . ^^^ Calcitonin receptor like receptor ( CRLR , now known as CL ) can function as either an AM receptor or a CGRP receptor , when cotransfected with receptor activity modifying proteins ( RAMPs ) that define ligand binding specificity . ^^^ Calcitonin receptor like receptor ( CRLR , now known as CL ) can function as either an AM receptor or a CGRP receptor , when cotransfected with receptor activity modifying proteins ( RAMPs ) that define ligand binding specificity . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Primary cultures of human osteoblast like cells ( hOB ) express calcitonin receptor like receptor ( CLR ) and receptor activity modifying protein 1 , and , because CGRP stimulates cAMP ( one of the modulators of OPG production in osteoblasts ) , it was investigated whether it affects OPG secretion and expression in hOB . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The study was performed in the presence or absence of the CGRP 1 ( calcitonin receptor like receptor ( CALCRL ) / receptor activity modifying protein 1 ( RAMP 1 ) ) receptor antagonists BIBN4096BS , CGRP ( 8 37 ) and the adrenomedullin receptor antagonist adrenomedullin ( 22 52 ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Associations between RAMPs and either CTR or CRLR give rise to seven distinct , molecularly characterized , receptors for CT , CGRP , amylin and adrenomedullin . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| First , we detected expression of the CGRP receptor subunits , calcitonin receptor like receptor and receptor activity modifying protein 1 in the GT 1 7 cells by reverse transcriptase polymerase chain reaction . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| CGRP and AM share a G protein coupled core receptor called calcitonin receptor like receptor ( CLR ) , and the specificity of the CLR is determined by the interaction with receptor activity modifying proteins ( RAMPs ) . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The calcitonin gene related peptide ( CGRP ) receptor is a heterodimer of a family B G protein coupled receptor , calcitonin receptor like receptor ( CLR ) , and the accessory protein receptor activity modifying protein 1 . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The ability of rIMD to induce heterologous desensitization of CGRP 1 receptor activation , to retain much of its pulmonary vasodilator activity after inhibition of CGRP 1 receptors , and to lack homologous desensitization together suggests the pulmonary , unlike the systemic , vasodilator response to rIMD may depend on other vasodilator mechanisms including receptors in the calcitonin receptor like receptor ( CRLR ) family . . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Osteoclast like cells expressed CT receptor ( CTR ) , CT receptor like receptor ( CRLR ) and RAMP 2 , but did not express RAMP 1 or RAMP 3 . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Adrenomedullin ( AM ) and calcitonin gene related peptide ( CGRP ) have structural similarities , interact with each others receptors ( calcitonin receptor like receptor ( CLR ) / receptor activity modifying proteins ( RAMPs ) ) and show overlapping biological activities . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| CGRP receptor markers ( CRLR and RAMP 1 ) were expressed in invading macrophages . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| In this study we aimed to assess in vivo , the vasodilator effects of adrenomedullin , proadrenomedullin N terminal 20 peptide ( PAMP ) and amylin in human skin vasculature and compare the responses to the effects mediated by the endogenous neuropeptides calcitonin gene related peptide ( CGRP ) and substance P and to examine the mRNA expression of calcitonin receptor like receptor ( CL R ) and receptor activity modifying proteins , RAMP 1 , RAMP 2 and RAMP 3 in human subcutaneous arteries . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| The receptor activity modifying proteins ( RAMPs ) were shown to be essential for the expression of a functional CRLR and furthermore the RAMPs seemed to modify ligand selectivity of CRLR : coexpression of CRLR and RAMP 1 resulted in a CGRP 1 type of receptor while an adrenomedullin receptor resulted when CRLR and RAMP 2 were coexpressed . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| RAMP association with the calcitonin ( CT ) receptor like receptor ( CRLR ) traffics this receptor to the cell surface where individual RAMPs dictate the expression of unique phenotypes . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| Accumulating evidence indicate that the calcitonin ( CT ) receptor , the CT receptor like receptor ( CRLR ) and receptor activity modifying proteins ( RAMPs ) form the basis of all the receptors in this family of peptides . 2 . ^^^ Using reverse transcriptase polymerase chain reaction the presence of mRNA sequences encoding the CRLR , RAMP 1 and RAMP 2 were demonstrated in porcine left anterior descending ( LAD ) coronary arteries , whereas porcine calcitonin ( CT ) receptor mRNA was not present . ^^^ |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and Q16602 |
Pubmed |
SVM Score :0.0 |
| NA |
|