| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.8992886 |
| It has been shown that the complex between calcitonin receptor like receptor ( CRLR or CL ) and receptor activity modifying protein ( RAMP ) 1 provides a molecular correlate for the CGRP ( 1 ) receptor ; however , this does not explain the range of affinities seen for CGRP ( 8 37 ) in isolated tissues . 0.8992886^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.85066069 |
| The CTR interacts with CT and does not require a known RAMP for functional expression . 0.85066069^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| These studies suggest that CGRP initially interacts with the calcitonin receptor to produce a calcitonin like effect , which is followed by hypercalcaemia presumably by antagonising the action of endogenous circulating calcitonin . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Though from our studies it would seem reasonably clear that CGRP is weakly agonistic for the calcitonin receptor on the osteoclast to produce effects on bone resorption and plasma calcium , it is still unclear whether the elevation of bone cyclic AMP simply represents an osteoclastic effect or an additional , more important , effect on osteoblasts . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| We have therefore suggested that the calcitonin like effects of CGRP , seen both in vivo in the rat bioassay and in vitro in organ cultures , are due to the direct action of CGRP on the osteoclast , probably mediated through the calcitonin receptor . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| CHO cells stably transfected with an expression vector for the porcine calcitonin receptor were exposed to various concentrations of IAPP , CGRP or calcitonin from different species . ^^^ These results demonstrate that IAPP and CGRP can mediate signal transduction via the porcine calcitonin receptor and provide a possible explanation for the calcitonin like effects of pharmacological levels of IAPP and CGRP administrated in vivo . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| We report here the cloning of a complementary DNA ( cDNA ) encoding a human CGRP 1 receptor , which shares significant peptide sequence homology with the human calcitonin receptor , a member of the G protein coupled receptor superfamily . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Although the calcitonin receptor does not require RAMP to bind and respond to calcitonin , it can associate with the RAMPs , resulting in a series of receptors that typically have high affinity for amylin and varied affinity for CGRP . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Unlike the interaction between CT and CTR , receptors for the related hormones and neuropeptides amylin , CT gene related peptide ( CGRP ) and adrenomedullin ( AM ) require one of three accessory receptor activity modifying proteins ( RAMPs ) for ligand recognition . ^^^ An amylin / CGRP receptor is revealed when CTR is co expressed with RAMP 1 . ^^^ CTR RAMP 1 , antagonized preferentially by salmon CT ( 8 32 ) and not by CGRP ( 8 37 ) , and CRLR RAMP 1 , antagonized by CGRP ( 8 37 ) , are two CGRP receptor isotypes . ^^^ Thus amylin and CGRP interact specifically with heterodimeric complexes between CTR and RAMP 1 or RAMP 3 , and CGRP and AM interact with complexes between CRLR and RAMP 1 , RAMP 2 or RAMP3 . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Similar expressions of the VIP and CGRP R transcripts were observed in PTEC , whereas the CT R message was not detected . ^^^ In LT TEC , the signals for VIP R , CGRP R , and CT R transcripts were seen with a lower intensity than those in control and MG thymus . ^^^ In agreement with our molecular analysis , 1 ) VIP was the most potent peptide among VIP related peptides ( VIP > PACAP > PHM > PHV ) to stimulate cAMP production through specific type 1 VIP receptors in both PTEC and LT TEC ; 2 ) cAMP generation was induced by CGRP in PTEC and by CT in LT TEC ; 3 ) in frozen thymic sections and by flow cytometry , type 1 VIP R , CGRP R , and CT R were localized in epithelial cells ; and 4 ) in parallel , the transcription of the acetylcholine receptor alpha subunit ( the main autoantigen in MG ) was induced by CGRP and CT in PTEC and LT TEC , respectively . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Recently , we reported the cloning of complementary DNAs ( cDNAs ) encoding the human and porcine CGRP receptors which share significant amino acid sequence homology with the human calcitonin receptor , a member of the recently described novel subfamily of G protein coupled 7TM receptors . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Calcitonin ( CT ) , calcitonin gene related peptide ( CGRP ) , amylin , and adrenomedullin constitute a family of structurally related peptides that signal via either the calcitonin receptor like receptor or the CT receptor , with receptor phenotype determined by coexpression of one of the three receptor activity modifying proteins ( RAMPs ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| It has recently been shown that the molecular pharmacology of CGRP and ADM is determined by coexpression of one of three receptor activity modifying proteins ( RAMPs ) with calcitonin receptor like receptor ( CRLR ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The initially orphan calcitonin receptor like receptor ( CRLR ) was identified as a CGRP receptor when coexpressed with RAMP 1 . ^^^ An amylin / CGRP receptor was recognized when a calcitonin receptor ( CTR ) was coexpressed with RAMP 1 . ^^^ Thus , two Class 2 G protein coupled receptors , the CRLR and CTR , associate with three RAMP to form high affinity receptors for CGRP , ADM , or amylin . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| We tested whether heterodimers comprised of calcitonin ( CT ) receptor lacking the 16 amino acid insert in intracellular domain 1 ( CTR ( I 1 ) ) and receptor activity modifying protein ( RAMP ) can function not only as calcitonin gene related peptide ( CGRP ) receptors but also as adrenomedullin ( AM ) receptors . ^^^ However , the apparent potency of AM , like that of CGRP , approached that of CT when CTR ( I 1 ) was co expressed with RAMP . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Among them , AM and CGRP are reported to share a core receptor , the calcitonin receptor like receptor ( CRLR ) , and the specificity of the CRLR is determined by the expression levels of receptor activity modifying proteins ( RAMPs ) . ^^^ The specificity of CRLR was clearly determined by the expression of RAMPs ; RAMP 1 converted CRLR to CGRP receptor , while RAMP 2 and RAMP 3 converted it to AM receptor , but the affinity of CTR for AMY was not increased by the expression of any known RAMPs . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| CGRP receptor belongs to the calcitonin receptor like receptor ( CRLR ) family of G protein coupled receptors and has been shown to require a single transmembrane domain protein called receptor activity modifying protein 1 ( RAMP 1 ) for its functional expression as well as activity . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The purpose of the present study was to characterize the effects of human ( h ) alpha and beta calcitonin gene related peptide ( CGRP ) on intracranial arteries from man and to investigate the presence of mRNA for the calcitonin receptor like receptor ( CRLR ) and the receptor activity modifying proteins ( RAMPs ) 1 , 2 and 3 , in cerebral and middle meningeal arteries with and without endothelium , in microvessels and in the endothelial cells isolated from the human basilar artery . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| CGRP , AMY and AM receptors are complexes which include a GPCR ( the CT receptor or CTR and calcitonin receptor like receptor or CRLR ) and a single transmembrane domain protein known as receptor activity modifying proteins ( RAMPs ) as well as an intracellular protein named receptor component protein ( RCP ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| CGRP receptors are observed in presence of the RAMP1 / calcitonin receptor like receptor ( CRLR ) , but the association of RAMP 2 or RAMP 3 with CRLR generates an adrenomedullin receptor . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The calcitonin receptor is specific for calcitonin when expressed alone but it can function as an amylin or CGRP receptor when co expressed with a RAMP . ^^^ The calcitonin receptor like receptor ( CRLR ) will not reach the cell surface without any one of the three RAMP proteins to function as either a CGRP or adrenomedullin receptor . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| CLR and CTR are members of the class 2 ( family B ) G protein coupled receptors ( GPCR ) and bind calcitonin gene related peptide ( CGRP ) with similar affinities when coexpressed with RAMP 1 . ^^^ The observation that various nonpeptide CGRP receptor antagonists display a higher affinity for the CLR / RAMP1 complex than for CTR / RAMP1 provided an opportunity to investigate the molecular determinants of the differential receptor affinities of these antagonists . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Deletions of genes encoding calcitonin / alpha CGRP , amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor like receptors in bone . ^^^ CGRP belongs to the calcitonin ( CT ) family of peptides also including CT , amylin and adrenomedullin , as well as the recently described intermedin and calcitonin receptor stimulating peptide . ^^^ Associations between RAMPs and either CTR or CRLR give rise to seven distinct , molecularly characterized , receptors for CT , CGRP , amylin and adrenomedullin . ^^^ It was anticipated that deletions of the CT / alpha CGRP and CTR genes would lead to bone loss , since CT has been shown to inhibit bone resorption in vitro and in vivo and has been used to treat patients with excessive bone resorption . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| A human ovarian small cell carcinoma line ( BIN 67 ) expresses abundant calcitonin ( CT ) receptors ( CTR ) ( 143 , 000 per cell ) that are coupled , to adenylate cyclase . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| In the experiment of reading CT images as a routine daily work at the CRT workstation , the average time required to analyse one CT image under a room illuminance of 100 lux was longer than that on the film viewbox . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Characteristic curves were determined for both monitors , and CRT gammas were 3 . 34 and 2 . 48 for the perceptual workstation and CT console , respectively . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| It permits CT based patient specific hyperthermia models to be constructed without tedious manual contouring on digitizing pads or CRT screens . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| In the remaining 5 patients , excellent clinical improvement was observed with the reduction of CTR and echo cardiographic findings without formation of hematoma , pseudoaneurysm , and leak from the suture lines on DSA and CT . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Whether the display medium film versus cathode ray tube ( CRT ) affects observer performance during interpretation of computed tomographic ( CT ) images is an important research issue in these times of implementation and growth of picture archiving and communications systems in radiology . ^^^ The results of this study demonstrate that current CRT display technology is adequate for enabling the primary detection of abdominal masses with CT examinations . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The bioavailability and pharmacokinetics of a new controlled release tablet ( CRT ) of naproxen ( 750 mg tablet ) have been determined , relative to an equivalent dose of conventional product ( CT ) , by a cross over study in twenty healthy volunteers . ^^^ The mean residence time and the absorption and elimination half lives of the CRT were also substantially longer than those of the CT . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The chlortetracycline ( CT ) resistance gene ctr was cloned from S . aureofaciens 633 , a strain producing the antibiotic . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The incidence , 10 year actuarial risk ( AR ) , and relative risk ( RR ) of a second malignancy developing were calculated for the 407 patients who were treated with surgery alone , 226 who were treated with surgery followed by adjuvant chemotherapy ( CT ) , 140 who were treated with surgery plus adjuvant radiation therapy ( RT ) , and 308 who received all three modalities ( CRT ) . ^^^ The AR of a subsequent cancer ( 8 . 4 % for CRT , 8 . 7 % for CT , 8 . 7 % for RT , and 11 . 7 % for surgery only patients ) did not differ significantly between treatment groups . ^^^ The overall second cancer RR was 1 . 0 % after CRT ( 95 % confidence interval [ CI ] , 0 . 4 to 2 . 0 ) , 1 . 3 % after RT ( 95 % CI , 0 . 6 to 2 . 5 ) , 1 . 6 % after CT ( 95 % CI , 0 . 9 to 2 . 6 ) , and 1 . 7 % after surgery alone ( 95 % CI , 1 . 2 to 2 . 4 ) . ^^^ The RR for acute leukemia was 16 . 7 % in the CRT group ( 95 % CI , 0 . 2 to 92 . 7 ) , 11 . 1 % in the CT group ( 95 % CI , 0 . 1 to 61 . 8 ) , 10 . 0 % in the surgery alone group ( 95 % CI , 1 . 1 to 36 . 1 ) , and 0 . 0 % in the RT group ( 95 % CI , 0 . 0 to 61 . 1 ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Eight of these 24 patients with CRT findings on MR had CT abnormalities that correlated with the MR . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| This potential pitfall in CT interpretation can be avoided by taking proper measures to avoid film artifacts and by reviewing all cases on the cathode ray tube ( CRT ) display as well as the hard copy film . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| An automatic computer technique was designed to produce three dimensional ( 3D ) images of bony anatomy on a cathode ray tube ( CRT ) from computerized tomography ( CT ) data . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The microassay of hyaluronic acid concentration and hyaluronidase activity by capillary turbidity ( CT ) and capillary turbidity reduction ( CTR ) tests . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Eighty eight percent of patients treated with chemotherapy alone had CT abnormalities , and all treated with CRT and chemotherapy had abnormal CT . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The cathode ray tube ( CRT ) as a source of `` grainy ' ' CT images . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Recently , a 52 % incidence of abnormal computed tomography ( CT ) brain scans was found in asymptomatic children with ALL whose CNS prophylaxis consisted of CRT and either IT MTX or intrathecal cytosine arabinoside ( IT Ara C ) . ^^^ This would suggest that MTX alone in the absence of CNS leukemia or CRT is highly unlikely to produce structural CNS abnormalities detectable by CT . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Clinical evaluation of newly developed CRT viewing station : CT reading and observer ' s performance . ^^^ No significant differences in reading time existed between CRT and film in 3 of 4 readers in head CT series , and in 2 of 6 readers in body CT series . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Two markers of the OC phenotype , calcitonin ( CT ) receptor ( CTR ) and tartrate resistant acid phosphatase ( TRAP ) , were assessed . ^^^ CT ( 10 ( 7 ) M ) treatment of 7 day cultures , which had been stimulated to express the osteoclastic phenotype , caused a marked decrease in CTR mRNA expression at 24 h . ^^^ There was no effect of CT treatment on CTR mRNA expression at 3 h or on TRAP mRNA expression at 3 or 24 h . ^^^ In neonatal mouse calvaria cultures , CTR mRNA expression was constitutively present and was markedly decreased by 48 h of CT treatment . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Untransfected cells , cells transfected with vector alone , and CTR transfected cells not treated with CT , were unresponsive to [ Ca2+ ] e . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| CTR bearing cells were detected by autoradiography of 125I salmon CT binding , and cultures were stained for tartrate resistant acid phosphatase ( TRAP ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Removal of CT results in the recovery of CT receptor ( CTR ) binding . ^^^ For the experiments , osteoclast like cell ( OCL ) enriched populations were subcultured from the collagen gels into multiwell dishes on days 7 8 , and CT regulation of the CTR was determined and compared with that in T47D cells . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Two distinct calcitonin ( CT ) receptor ( CTR ) encoding cDNAs ( designated GC 2 and GC 10 ) were cloned and characterized from giant cell tumor of bone ( GCT ) . ^^^ Expression of all three CTR isoforms in COS cells demonstrated that GC 2 has a lower binding affinity for salmon ( s ) CT ( Kd approximately 15 nM ) than GC 10 or o hCTR ( Kd approximately 1 . 5 nM ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Binding studies of 125I labeled calcitonin ( CT ) showed that the Ag was not the CT receptor ( CTR ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| During the procedure , the coordinates on the patient ' s head are automatically entered into the computer and matched with those of the 3 D digitizer and CT / MR images on the CRT display . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| We have reported that calcitonin ( CT ) treatment induced downregulation of the CT receptor ( CTR ) in mouse osteoclast like cells ( OCLs ) . ^^^ Treatment of OCLs with activators of protein kinase A ( PKA ) mimicked the effect of CT on CTR downregulation , whereas neither activation of protein kinase C nor elevation of intracellular Ca2+ did so . ^^^ Attenuation of CT induced CTR down regulation by the competitive cAMP antagonist , RpcAMP , and high concentrations of H 7 , but not by protein kinase C specific inhibitors ( sphingosine , staurosporine , and a lower concentration of H 7 ) , suggested that the PKA pathway is primarily involved in homologous regulation of the CTR . ^^^ The changes in CTR messenger RNA confirm the findings in binding studies and demonstrate that CT treatment of OCLs results in decreased CTR synthesis through the PKA pathway . ^^^ The low concentrations of hCT that result in CTR regulation are very close to the physiological range , providing new insights into a dynamic relationship between circulating levels of CT and CTR expression in osteoclasts . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to investigate homologous regulation of the CTR , and regulation of TRAP expression in osteoclast like cells after brief treatment with salmon CT ( sCT ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| We have reported that short calcitonin ( CT ) treatment of mature mouse osteoclast like cells ( OCLs ) in culture induced prolonged down regulation of the CT receptor ( CTR ) and desensitization to CT rechallenge , at the level of adenylate cyclase activity . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| UMR 106 06 cells predominantly express the C1a isoform of the rat calcitonin ( CT ) receptor ( CTR ) . ^^^ It was found that treatment of both cell lines with either salmon CT or human CT reduced the density of cell surface CTR in a dose and time dependent manner . ^^^ CT induced down regulation of the CTR was not mimicked by receptor independent activation of protein kinase A or protein kinase C . ^^^ These results suggest that CT induced receptor down regulation and modulation of the ability of CT to activate adenylate cyclase are inherent properties of the receptor , as they can be recapitulated in an otherwise CTR naive cell line , in which receptor expression is driven by a heterologous gene promoter . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The studies covered serum levels of total and ionized calcium ( Ca ) , parathyroid hormone ( PTH ) , calcitriol ( Ctr ) and calcitonin ( Ct ) in miners assigned to various occupational groups and suffering from deforming osteoarthrosis . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to examine the effects of continuous treatment with CT on the generation of osteoclasts and calcitonin receptor ( CTR ) expression in mouse bone marrow cultures . ^^^ Continuous CT treatment of cultures from day 6 rapidly reduced the CTR mRNA levels , with a t1 / 2 of 6 to 12 h , and these levels remained low thereafter . 125I salmon CT binding capacity , as determined by autoradiography , was lost in parallel . ^^^ Based on these data , we suggest that the `` escape ' ' phenomenon may result from a prolonged CT induced loss of CT responsiveness due , at least in part , both to reduced synthesis of CTR , and to the appearance in bone of CTR deficient osteoclasts . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| We previously studied regulation of the calcitonin ( CT ) receptor ( CTR ) by glucocorticoid ( GC ) and CT in cultures of mature mouse osteoclast like cells ( OCLs ) . ^^^ The present studies were designed to examine the interaction of CT and GC in regulation of the CTR in osteoclasts and the molecular mechanisms involved . ^^^ Treatment of OCLs with 10 ( 7 ) M dexamethasone ( Dex ) increased the CTR number in a time dependent manner , whereas treatment with 10 ( 9 ) M salmon CT ( sCT ) reduced CTR number ; neither treatment changed receptor affinity . ^^^ Interestingly , transcriptional inhibition by 5 , 6 dichloro 1 beta D ribofuranosyl benzimidazole abolished the ability of CT to reduce CTR mRNA levels , suggesting that CT may act by increasing the rate of CTR mRNA decay , and that this effect requires ongoing transcription . ^^^ These results show that GC and CT influence CTR expression by distinct mechanisms and provide the basis for identification of the cellular factors involved . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Isoforms of the CT receptor ( CTR ) , with interesting functional differences , have been identified and a new form of the PTH receptor , highly specific for PTH , has been cloned . ^^^ Investigation of the homologous regulation of the CTR in osteoclasts by CT treatment of mouse marrow cultures , has shown that continuous exposure to CT results in formation of resorption competent , CTR deficient osteoclasts . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Calcitonin ( CT ) is a 32 amino acid calciotropic peptide hormone which acts on target cells via a G protein coupled seven transmembrane receptor ( CTR ) . ^^^ Upon photolysis , in the presence of CTR , the radioiodinated photoreactive CT analog ( [ Arg 11 , 18 , Lys 19 ( epsilon pBz 2 ) ] sCT ( K 19 ) ) covalently labels a membrane component of approximately 70 kDa . ^^^ We also examined the interaction of these CT analogs with a hemagglutinin ( HA ) epitope tagged CTR . ^^^ The HA CTR displayed CT binding and CT dependent cAMP stimulation identical with native CTR . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Results were compared in terms of chemotherapy ( CT ) dose tolerated , morbidity of CRT , response rates , and surgical outcome in groups with and without PNS . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Moreover , CT and CTR mRNA levels were modified significantly during proliferation . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Autocrine regulation of CTR is also suggested by relation between CT mRNA levels and CTR mRNA . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| In contrast , survivals in the 24 to 36 month group are much better than previous reports in the literature suggesting that prolonged postoperative CT may allow both a delay in CRT as well as provide improved survivals . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| METHODS AND MATERIALS : Weekly computed tomography ( CT ) scans of the pelvis ( n=51 ) and daily electronic portal images ( n=1630 ) were reviewed for eight patients who received seven field 3D CRT for prostate cancer . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Requiring the prescription dose to conform as closely as possible to the target volume raises the level of the precision and accuracy requirements generally found in conventional radiation therapy . 3D CRT treatment planning requires robust patient immobilization / repositioning systems and volumetric image data ( CT and / or MR ) acquired in the treatment position . 3D treatment planning more explicitly details the particulars of a patient ' s treatment than was ever possible with 2D treatment planning . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The copper transport genes CTR 1 and CTR 2 were also excluded as candidate genes for CT since they both mapped to canine chromosome region CFA11q22 . 2 22 . 5 . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To analyze the failure patterns for patients with high grade astrocytomas treated with high dose conformal radiotherapy ( CRT ) using a quantitative technique to calculate the dose received by the CT or MR defined recurrence volume and to assess whether the final target volume margin used in the present dose escalation study requires redefinition before further escalation . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Although expression of the calcitonin ( CT ) receptor ( CTR ) decreases after CT binding , there has been no evidence that it occurs at the transcriptional level . ^^^ In the present study we investigated the mechanism of CTR messenger RNA ( mRNA ) down regulation by CT in mouse cocultures of bone marrow and osteoblasts . ^^^ Moreover , competitive RT PCR analysis revealed that 1 h treatment with CT reduced the level of CTR heterogeneous nuclear RNA to 10 % in a cycloheximide independent manner . ^^^ These results suggest that CT down regulates C1a CTR mRNA expression at least in part by a transcriptional mechanism , thereby contributing to the ligand induced desensitization in cells of the osteoclast lineage . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| For input 3D data from MRI or CT are used to display 3D images , HMD ( head mounted display ) and 3D CRT display with glass are equipped . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| MATERIAL AND METHODS : With the introduction of CT planning systems and the development of 3D conformal radiation therapy ( 3D CRT ) techniques , it has become feasible to deliver adequate doses of radiation to the target ( neck ) and at the same time saving ( parts of ) the salivary glands from doses beyond tolerance . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| We investigated the mechanisms by which calcitonin ( CT ) suppresses cellular proliferation , using HEK 293 cells stably transfected with either the rat C1a CT receptor ( CTR ) or the insert negative form of the human CTR . ^^^ CT treatment of the human and rat CTR expressing cell lines resulted in a rapid and sustained induction of mRNA encoding the cyclin dependent kinase inhibitor , p21WAF1 / CIP1 , increased levels of which were maintained at least 48 h after initiation of treatment . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Hard copy ( film ) versus soft copy ( CRT ) reading performance between compressed and uncompressed images : SOLs in abdominal CT images ] . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| In a radioligand binding assay , COS 1 cells transfected with the osteoclast CTR gene bound to [ 125I ] human CT ( hCT ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Based upon the analysis of conserved regions in G protein coupled receptors , two nonoverlapping regions in the heptahelical porcine CT receptor ( CTR ) were selected as candidate Gs interacting domains : the third intracellular loop residues 327 344 ( KLKESQEAESHMYLKAVR , P 3 region ) and the C tail residues 404 418 ( KRQWNQYQAQRWAGR , P 4 region ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| METHODS : We examined the effects of continuous CT treatment on cell formation , calcitonin receptor ( CTR ) expression , response to CT , and bone resorption of osteoclasts in a coculture of mouse marrow stromal and spleen cells in the presence of 1 , 25 dihydroxyvitamin D 3 [ 1 , 25 ( OH ) 2D3 ] . ^^^ CONCLUSION : These findings suggest that the escape phenomenon that develops after continuous CT treatment may be due , at least in part to : 1 ) loss of responsiveness to CT in existing osteoclasts ; and 2 ) development of new osteoclasts that are CTR deficient and , therefore , refractory to CT rechallenge . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| In order to evaluate the results of future trials without bias and to determine which group of esophageal patients will benefit from preoperative CRT , pretreatment , accurate TNM staging by CT and EUS combined with pathologic LN staging when possible will be crucial in future trimodality therapy trials for esophageal cancer . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| We reported previously that calcitonin ( CT ) receptor ( CTR ) mediated growth inhibition of HEK 293 cells stably transfected with the human CTR is accompanied by a rapid and sustained induction of p 21 and cell cycle arrest in G 2 . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| A few studies have been reported that CT cine viewing on the CRT is superior to film based viewing of CT images ( Seltzer et al . , Radiology 197 ( 1994 ) 119 ; Bonaldi et al . , Am . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| We concluded that the loss of CT binding in WAG / Rij rat is not related to CTR gene abnormality . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Using mouse osteoclast like cells ( OCs ) , we have shown that short exposure to calcitonin ( CT ) resulted in prolonged reduction of CT binding by inhibiting de novo CT receptor ( CTR ) synthesis . ^^^ In this study , we examined the features of CTR down regulation and its recovery after short exposure to CT of human OCs . ^^^ These data suggest that the PKC pathway plays an important role in homologous CTR down regulation , as well as inhibition of bone resorbing activity by CT , in human OCs . ^^^ The reduced specific binding , CTR messenger RNA levels , and CT sensitive adenylate cyclase responsiveness returned to the control levels by 96 h after removal of CT . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Using mouse osteoclast like cells ( OCs ) , we have shown that treatment with glucocorticoids ( GCs ) resulted in an increase in calcitonin ( CT ) binding by enhancing CT receptor ( CTR ) gene transcription . ^^^ In this study we examined CTR regulation by GCs and the effects of GCs and CT together in human OCs . ^^^ This suggests that GCs and CTs act on CTR expression differently , consistent with our previous work using mouse OCs , in which we found that GCs increased transcription of CTR gene expression , whereas CT reduced CTR mRNA stability . ^^^ The results obtained in this study show that GC increased CTR expression and sensitivity to CT in cells of the human osteoclast lineage and provide the basis for understanding the beneficial effects of combination treatment with GCs and CTs in malignancy associated hypercalcemia . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| A similar function has been ascribed to RAMP interaction with the CT receptor ( CTR ) gene product . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Calcitonin ( CT ) , a 32 amino acid peptide hormone produced primarily by the thyroid , and its receptor ( CTR ) are well known for their ability to regulate osteoclast mediated bone resorption and enhance Ca2+ excretion by the kidney . ^^^ In this review article , CT and CTR gene transcription , signal transduction and function are addressed . ^^^ The effects of CT on the physiology of a variety of organ systems are discussed and the relationship between polymorphisms in the CTR gene and bone mineral density ( BMD ) / osteoporosis is examined . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| We have identified a polymorphism at position 1377 of the calcitonin receptor ( CTR ) gene which generates CC , CT , or TT genotype . ^^^ The CTR genotypic frequencies in the Japanese population were 77 . 0 % for CC , 20 . 4 % for CT , and 2 . 6 % for TT . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Present studies extended these findings by cloning cDNAs for CT and CT receptor ( CT R ) from prostate cancer cells and studying the expression of CT and CT R mRNA in prostate cancer cell lines and primary prostate tumor specimens . ^^^ The results have shown that PC 3 cells expressed CT , and not CT R , mRNA , whereas CT R , but not CT , mRNA was expressed by LNCaP cells . ^^^ Highly aggressive PC 3M cells co expressed CT and CT R mRNAs . ^^^ In situ hybridization histochemistry of archival prostate specimens has selectively localized CT and CT R mRNA in basal epithelium of benign and low grade PC specimens , and these mRNAs were not detected in either luminal epithelium or stroma . ^^^ In contrast , CT and CT R mRNA were detected throughout the luminal epithelium of moderate and high grade PC specimens . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The structure of a receptor for CT ( CTR ) was elucidated in 1991 through molecular cloning , but the structures of the receptors for the other three peptides had yet to be elucidated . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| CT scans in 65 patients were analyzed for emphysema extent and distribution using the percentage of emphysema in the lung , percentage of normal lower lung , and the CT emphysema ratio ( CTR , an index of the craniocaudal distribution of emphysema ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Interobserver variability was also significantly correlated by computed tomographic ( CT ) and magnetic resonance imaging ( MRI ) discography for disc normality ( CT r = 0 . 60 ; MRI r = 0 . 56 ) , general degeneration ( CT r = 0 . 76 ; MRI r = 0 . 71 ) , anular fissure ( CT r = 0 . 79 ; MRI r = 0 . 84 ) , and disc herniation ( CT r = 0 . 63 ; MRI r = 0 . 64 ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The phenotype of these cells was confirmed by demonstration of characteristics typical of osteoclasts ( OCs ) including : the expression of tartrate resistant acid phosphatase ( TRAP ) , the vitronectin receptor ( VNR ) and the calcitonin receptor ( CTR ) , the demonstration of responsiveness to calcitonin ( CT ) and the ability to form resorption lacunae on ivory slices and calcium phosphate films . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : The objective of this study is to describe the CT patterns of radiation injury in the lungs of patients who have undergone three dimensional ( 3D ) conformal radiation therapy ( CRT ) . ^^^ MATERIALS AND METHODS : Over a 36 month period , the chest CT scans of 19 patients with non small cell lung cancer who were treated with 3D CRT were reviewed . ^^^ Knowledge of the full spectrum of these manifestations is useful in the correct interpretation of CT scans after 3D CRT . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| As reconstruction delay time of the procedures has been shortened from 1 . 0 sec . to 0 . 6 sec . , real time CT fluoroscopy monitoring is possible on the Cathode Ray Tube ( CRT ) monitor in the CT room , very closed to the patient . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| We recently reported that calcitonin ( CT ) can profoundly inhibit the growth of HEK 293 cells transfected with the human calcitonin receptor ( hCTR ) . ^^^ Under these conditions , we have found that CT treatment of HEK 293 cells stably transfected with the insert negative form of the human CTR ( HR 12 cells ) caused a time dependent decrease in cell number associated with loss of cellular attachment . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| In conducting this analysis , we assumed that CRT diagnosis initially would be limited to CT and MR . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : The addition of electron density information to MR images for conformal radiotherapy ( CRT ) planning of the prostate was quantified by comparing dose distributions created on the homogeneous density and bulk density assigned images to original CT for four patients . ^^^ Dose statistics from CRT treatment plans made on CT and MR for five patient data were compared to determine if MR only treatment plans can be made . ^^^ CONCLUSIONS : Negligible differences were observed in dose distribution between CRT plans using bone+water CT number bulk assigned image and original CT . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to evaluate feasibility of reporting brain CT examinations on liquid crystal display ( LCD ) flat screen monitors vs state of the art cathode ray tube ( CRT ) monitors . ^^^ Ninety five brain CT examinations of 95 patients were displayed on Picture archiving and communications system ( PACS ) workstations equipped either with a dedicated medical imaging LCD colour monitor or on a high resolution CRT which is used for routine reporting of CT , MRI and digital radiography images in our institution . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| On the basis of these results , we conclude that the cloned receptor is the CT receptor ( CTR ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : Fifty six consecutive patients with nonmetastatic esophageal cancer were treated with primary CRT between May 1993 and April 1999 with curative intent and subsequent surveillance with endoscopy and CT scans . ^^^ Patients with residual disease on endoscopy and / or CT 6 weeks after CRT were considered for immediate esophagectomy . ^^^ On univariate analysis , favorable prognostic factors for disease specific survival were female gender ( p = 0 . 026 ) , CT defined N ( 0 ) status ( p = 0 . 027 ) , and negative endoscopy at 6 weeks after CRT ( p < 0 . 0001 ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| In cellular systems , AMY binding is generated by interaction of calcitonin receptor a / b ( CT ( ( a ) ) / CT ( ( b ) ) ) with receptor activity modifying proteins ( RAMPs ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Our previous results in mouse osteoclasts suggested that calcitonin ( CT ) alters CT receptor ( CTR ) mRNA stability . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Calcitonin ( CT ) inhibits the growth of human breast cancer cell lines and calcitonin receptor ( CTR ) is expressed in breast cancer lines and breast cancer tissue . ^^^ Further studies are needed to clarify the role of CT and CTR in human breast tissue . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| There is a growing body of evidence indicating that calcitonin ( CT ) and its receptor ( CTR ) is involved in cell growth , differentiation and tissue development . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Almost 20 % of locally advanced tumors on initial staging CT can be resected following CRT . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| This study compared the safety and efficacy of concurrent and sequential CRT , with chemotherapy ( CT ) consisting of a cisplatin and vinorelbine regimen , in patients with locally advanced NSCLC . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : This study evaluates the utility of positron emission tomography ( PET ) , endoscopic ultrasonography ( EUS ) , and computed tomographic ( CT ) scans to predict pathologic response and survival following preoperative chemoradiation ( CRT ) in esophageal cancer . ^^^ PET , EUS , and CT were performed before ( pre ) or after ( post ) CRT and before surgical resection . ^^^ Post CRT measurements that correlated with pathologic response were : CT esophageal wall thickness ( 13 . 3 vs 15 . 3 mm , p = 0 . 04 ) , EUS mass size ( 0 . 7 vs 1 . 7 cm , p = 0 . 01 ) and PET SUV ( 3 . 1 vs 5 . 8 , p = 0 . 01 ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Proctoscopy , digital rectal examination ( DRE ) , computer tomography ( CT ) , endorectal ultrasound ( ERUS ) , and magnetic resonance imaging ( MRI ) can not correctly detect downstaging in rectal tumors after chemo radiation therapy ( CRT ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Previously , we cloned a GPCR ( G protein coupled receptor ) specific to CT [ CTR 1 ( CT receptor 1 ) ] . ^^^ CTR 2 and OPR expressed in Xenopus oocytes induced calcium mediated inward chloride current in a CT and OP specific manner respectively . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| When H CTR 6 was transiently expressed in HEK 293 cells , CT failed to induce production of cAMP or to bind to the receptor . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| However , we detected CTR immunoreactivity in several additional brain areas , as the ventromedial , lateral and posterior hypothalamus , where CT binding has not yet been described . ^^^ Our detailed mapping of the CTR in the rat brain has identified CTR positive cells that will be important for subsequent characterization of behavioral functions associated with the actions of CT related peptides . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Osteoclast like cells expressed CT receptor ( CTR ) , CT receptor like receptor ( CRLR ) and RAMP 2 , but did not express RAMP 1 or RAMP 3 . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| We and other investigators have studied the mechanism and the results indicated that desensitization to CT was closely associated with the down regulation of the CT receptor ( CTR ) . ^^^ Treatment with CT reduced concentration of cellular surface CTR and CTR mRNA expression also in human osteoclasts . ^^^ The reduced specific binding , CTR mRNA levels and CT sensitive adenylate cyclase responsiveness returned to the control levels by 96h after removal of CT . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| CT receptor ( CTR ) is expressed in malignant prostate epithelium , and its activation stimulates growth of prostate cancer ( PC ) cells via activation of adenylyl cyclase and calcium / phospholipid pathways . ^^^ To identify the role of `` CT System ' ' in prostate cancer , we tested the expression of CT and CTR mRNAs in invading tumor cells of prostate cancer specimens . ^^^ The cells of primary tumors and those invading stroma co expressed CT / CTR mRNAs . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To study the impact of fused ( 18 ) F fluoro deoxy D glucose ( FDG ) hybrid positron emission tomography ( PET ) and computed tomography ( CT ) images on conformal radiation therapy ( CRT ) planning for patients with esophageal carcinoma . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| To report a retrospective study concerning the impact of fused 18F fluorodeoxy D glucose ( FDG ) hybrid positron emission tomography ( PET ) and computed tomography ( CT ) images on three dimensional conformal radiation therapy ( 3D CRT ) planning for patients with non small cell lung cancer ( NSCLC ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The expression of calcitonin ( CT ) and CT receptor ( CTR ) mRNA in primary prostate tumors increase with tumor progression . ^^^ Cytoprotective action of CT is mediated by CTR induced activation of Akt survivin pathway . ^^^ Since CT / CTR expression in prostate cancers increases with tumor progression , the suppression of `` CT System ' ' may enhance the effectiveness of chemotherapy . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : Radiotherapy ( RT ) , chemotherapy ( CT ) and combined chemo radiotherapy ( CRT ) for newly diagnosed Hodgkin ' s disease are compared with respect to SM risk , overall ( OS ) and progression free ( PFS ) survival . ^^^ CRT , 16 ( 2861 ) for CT vs . ^^^ CRT was superior to CT in terms of PFS ( OR=77 , CI 0 . 68 to 0 . 77 , p < 0 . 0001 ) . ^^^ For advanced stages ( 3 4 ) , CRT better prevents progression / relapse but CT alone seems to cause less SM . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Reliability was assessed using the break point in heart rate ( HR ) linearity called the Conconi test ( CT ) and Conconi retest ( CRT ) for the noninvasive measurement of anaerobic threshold ( AT ) . ^^^ According to the results , the mean power output ( PO ) scores for the CT , CRT , and ILT were 234 . 2 + / 40 . 3 W , 232 . 5 + / 39 . 7 W , and 229 . 7 + / 39 . 6 W , respectively . ^^^ The mean HR values at the AT for the CT , CRT , and ILT were 165 . 4 + / 11 . 2 b . min , 160 . 4 + / 10 . 8 b . min , and 158 . 3 + / 8 . 8 b . min , respectively . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| CT receptor ( CTR ) is expressed in malignant prostate epithelium , and its activation increases invasiveness of prostate cancer ( PC ) cells via activation of protein kinase A . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The CT R [ calcitonin ( CT ) receptor ] is expressed in the central nervous system and is involved in the regulation of food intake , thermogenesis , and behaviors . ^^^ CT R stimulating peptide 1 ( CRSP 1 ) , a potent ligand for the CT R , was recently isolated from the porcine brain . ^^^ In this study , we first confirmed that porcine CRSP 1 ( pCRSP 1 ) enhanced the cAMP production in COS 7 cells expressing recombinant rat CT R , and then we examined the central effects of pCRSP 1 on feeding and energy homeostasis in rats . ^^^ These results suggest that CRSP 1 can function as a ligand for the CT R and may act as a catabolic signaling molecule in the central nervous system . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Pre CRT clinicopathologic features , including age , gender , location of the tumor , clinical tumor ( cT ) classification , clinical nodal ( cN ) classification , and serum CEA levels were investigated as possible predictors for the response to preoperative CRT . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| There is a growing body of evidence indicating that calcitonin ( CT ) and calcitonin receptor ( CTR ) are involved in the regulation of cell growth , differentiation , and survival and in tissue development . ^^^ However , the precise functional role of CT / CTR in breast cancer is still unknown . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The expression of human ( h ) calcitonin ( CT ) and its receptor ( CTR ) is localized to basal epithelium in benign prostates but is distributed in whole epithelium of malignant prostates . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Calcitonin ( CT ) and calcitonin receptor ( CTR ) have been reported to play an important role in mammary tissue during pregnancy , lactation , and involution . ^^^ CTR has been reported to act as an amylin receptor when heterodimerized with receptor activity modifying protein 1 ( RAMP 1 ) or RAMP 3 . mRNA expression of RAMP 1 and RAMP 3 in mammary tissue decreased during pregnancy and lactation , and amylin mRNA was undetectable , suggesting that up regulated CTR in lactating mammary tissues binds CT rather than amylin . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| Impact of radiotherapy ( RT ) schedule on local response and duration of the 5 fluorouracil / cisplatin ( 5 FU / CDDP ) chemotherapy ( CT ) on m are still questioning in chemoradiotherapy ( CRT ) regimen in esophageal carcinoma . ^^^ AIM : Evaluate two RT schedules and two different CT durations by a retrospective comparison of the CRT regimens used by two centres between 1994 and 2000 . ^^^ In centre 2 ( regimen 2 ) , patients received 6 CT , 3 were concomitant to a split course RT ( 20 Gy / 10 fractions 10 3 courses ) and 3 CT were delivered after CRT . ^^^ CONCLUSION : Clinical complete response to CRT was significantly more frequent with a continuous RT whereas additional CT after CRT significantly reduced metastasis occurrence . ^^^ CRT regimen in esophageal carcinoma may be more effective using a continuous RT schedule and additional CT courses after CRT completion . . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| The CT employed were : ( 1 ) CRT bacteria for MS and LB ; ( 2 ) CarioCheck Plus for MS and LB ; and ( 3 ) Dentocult SM and Mucount for MS . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| In PSVT , tau remained prolonged ( 49 + / 12 msec , p less than 0 . 05 versus CTR ) , Kc increased from 3 . 7 + / 1 . 0 in CTR to 7 . 4 + / 1 . 2 ( p less than 0 . 05 ) , and Km increased from 4 . 4 + / 1 . 5 in CTR to 13 . 9 + / 9 . 7 ( p less than 0 . 05 ) . ^^^ |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01258 and P30988 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.8992886 |
| It has been shown that the complex between calcitonin receptor like receptor ( CRLR or CL ) and receptor activity modifying protein ( RAMP ) 1 provides a molecular correlate for the CGRP ( 1 ) receptor ; however , this does not explain the range of affinities seen for CGRP ( 8 37 ) in isolated tissues . 0.8992886^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.85066069 |
| The CTR interacts with CT and does not require a known RAMP for functional expression . 0.85066069^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| These studies suggest that CGRP initially interacts with the calcitonin receptor to produce a calcitonin like effect , which is followed by hypercalcaemia presumably by antagonising the action of endogenous circulating calcitonin . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Though from our studies it would seem reasonably clear that CGRP is weakly agonistic for the calcitonin receptor on the osteoclast to produce effects on bone resorption and plasma calcium , it is still unclear whether the elevation of bone cyclic AMP simply represents an osteoclastic effect or an additional , more important , effect on osteoblasts . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| We have therefore suggested that the calcitonin like effects of CGRP , seen both in vivo in the rat bioassay and in vitro in organ cultures , are due to the direct action of CGRP on the osteoclast , probably mediated through the calcitonin receptor . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| CHO cells stably transfected with an expression vector for the porcine calcitonin receptor were exposed to various concentrations of IAPP , CGRP or calcitonin from different species . ^^^ These results demonstrate that IAPP and CGRP can mediate signal transduction via the porcine calcitonin receptor and provide a possible explanation for the calcitonin like effects of pharmacological levels of IAPP and CGRP administrated in vivo . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| We report here the cloning of a complementary DNA ( cDNA ) encoding a human CGRP 1 receptor , which shares significant peptide sequence homology with the human calcitonin receptor , a member of the G protein coupled receptor superfamily . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to examine the effects of continuous treatment with CT on the generation of osteoclasts and calcitonin receptor ( CTR ) expression in mouse bone marrow cultures . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Recently , we reported the cloning of complementary DNAs ( cDNAs ) encoding the human and porcine CGRP receptors which share significant amino acid sequence homology with the human calcitonin receptor , a member of the recently described novel subfamily of G protein coupled 7TM receptors . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Calcitonin ( CT ) , calcitonin gene related peptide ( CGRP ) , amylin , and adrenomedullin constitute a family of structurally related peptides that signal via either the calcitonin receptor like receptor or the CT receptor , with receptor phenotype determined by coexpression of one of the three receptor activity modifying proteins ( RAMPs ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| METHODS : We examined the effects of continuous CT treatment on cell formation , calcitonin receptor ( CTR ) expression , response to CT , and bone resorption of osteoclasts in a coculture of mouse marrow stromal and spleen cells in the presence of 1 , 25 dihydroxyvitamin D 3 [ 1 , 25 ( OH ) 2D3 ] . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| We have identified a polymorphism at position 1377 of the calcitonin receptor ( CTR ) gene which generates CC , CT , or TT genotype . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The phenotype of these cells was confirmed by demonstration of characteristics typical of osteoclasts ( OCs ) including : the expression of tartrate resistant acid phosphatase ( TRAP ) , the vitronectin receptor ( VNR ) and the calcitonin receptor ( CTR ) , the demonstration of responsiveness to calcitonin ( CT ) and the ability to form resorption lacunae on ivory slices and calcium phosphate films . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Although the calcitonin receptor does not require RAMP to bind and respond to calcitonin , it can associate with the RAMPs , resulting in a series of receptors that typically have high affinity for amylin and varied affinity for CGRP . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| We recently reported that calcitonin ( CT ) can profoundly inhibit the growth of HEK 293 cells transfected with the human calcitonin receptor ( hCTR ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The initially orphan calcitonin receptor like receptor ( CRLR ) was identified as a CGRP receptor when coexpressed with RAMP 1 . ^^^ An amylin / CGRP receptor was recognized when a calcitonin receptor ( CTR ) was coexpressed with RAMP 1 . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Among them , AM and CGRP are reported to share a core receptor , the calcitonin receptor like receptor ( CRLR ) , and the specificity of the CRLR is determined by the expression levels of receptor activity modifying proteins ( RAMPs ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| CGRP receptor belongs to the calcitonin receptor like receptor ( CRLR ) family of G protein coupled receptors and has been shown to require a single transmembrane domain protein called receptor activity modifying protein 1 ( RAMP 1 ) for its functional expression as well as activity . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The purpose of the present study was to characterize the effects of human ( h ) alpha and beta calcitonin gene related peptide ( CGRP ) on intracranial arteries from man and to investigate the presence of mRNA for the calcitonin receptor like receptor ( CRLR ) and the receptor activity modifying proteins ( RAMPs ) 1 , 2 and 3 , in cerebral and middle meningeal arteries with and without endothelium , in microvessels and in the endothelial cells isolated from the human basilar artery . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| In cellular systems , AMY binding is generated by interaction of calcitonin receptor a / b ( CT ( ( a ) ) / CT ( ( b ) ) ) with receptor activity modifying proteins ( RAMPs ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Calcitonin ( CT ) inhibits the growth of human breast cancer cell lines and calcitonin receptor ( CTR ) is expressed in breast cancer lines and breast cancer tissue . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| CGRP receptors are observed in presence of the RAMP1 / calcitonin receptor like receptor ( CRLR ) , but the association of RAMP 2 or RAMP 3 with CRLR generates an adrenomedullin receptor . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| It has recently been shown that the molecular pharmacology of CGRP and ADM is determined by coexpression of one of three receptor activity modifying proteins ( RAMPs ) with calcitonin receptor like receptor ( CRLR ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The calcitonin receptor is specific for calcitonin when expressed alone but it can function as an amylin or CGRP receptor when co expressed with a RAMP . ^^^ The calcitonin receptor like receptor ( CRLR ) will not reach the cell surface without any one of the three RAMP proteins to function as either a CGRP or adrenomedullin receptor . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| There is a growing body of evidence indicating that calcitonin ( CT ) and calcitonin receptor ( CTR ) are involved in the regulation of cell growth , differentiation , and survival and in tissue development . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Deletions of genes encoding calcitonin / alpha CGRP , amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor like receptors in bone . ^^^ CGRP belongs to the calcitonin ( CT ) family of peptides also including CT , amylin and adrenomedullin , as well as the recently described intermedin and calcitonin receptor stimulating peptide . ^^^ CGRP belongs to the calcitonin ( CT ) family of peptides also including CT , amylin and adrenomedullin , as well as the recently described intermedin and calcitonin receptor stimulating peptide . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Calcitonin ( CT ) and calcitonin receptor ( CTR ) have been reported to play an important role in mammary tissue during pregnancy , lactation , and involution . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| A human ovarian small cell carcinoma line ( BIN 67 ) expresses abundant calcitonin ( CT ) receptors ( CTR ) ( 143 , 000 per cell ) that are coupled , to adenylate cyclase . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| In the remaining 5 patients , excellent clinical improvement was observed with the reduction of CTR and echo cardiographic findings without formation of hematoma , pseudoaneurysm , and leak from the suture lines on DSA and CT . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| In PSVT , tau remained prolonged ( 49 + / 12 msec , p less than 0 . 05 versus CTR ) , Kc increased from 3 . 7 + / 1 . 0 in CTR to 7 . 4 + / 1 . 2 ( p less than 0 . 05 ) , and Km increased from 4 . 4 + / 1 . 5 in CTR to 13 . 9 + / 9 . 7 ( p less than 0 . 05 ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The chlortetracycline ( CT ) resistance gene ctr was cloned from S . aureofaciens 633 , a strain producing the antibiotic . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The microassay of hyaluronic acid concentration and hyaluronidase activity by capillary turbidity ( CT ) and capillary turbidity reduction ( CTR ) tests . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Two markers of the OC phenotype , calcitonin ( CT ) receptor ( CTR ) and tartrate resistant acid phosphatase ( TRAP ) , were assessed . ^^^ CT ( 10 ( 7 ) M ) treatment of 7 day cultures , which had been stimulated to express the osteoclastic phenotype , caused a marked decrease in CTR mRNA expression at 24 h . ^^^ There was no effect of CT treatment on CTR mRNA expression at 3 h or on TRAP mRNA expression at 3 or 24 h . ^^^ In neonatal mouse calvaria cultures , CTR mRNA expression was constitutively present and was markedly decreased by 48 h of CT treatment . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| CTR bearing cells were detected by autoradiography of 125I salmon CT binding , and cultures were stained for tartrate resistant acid phosphatase ( TRAP ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Removal of CT results in the recovery of CT receptor ( CTR ) binding . ^^^ For the experiments , osteoclast like cell ( OCL ) enriched populations were subcultured from the collagen gels into multiwell dishes on days 7 8 , and CT regulation of the CTR was determined and compared with that in T47D cells . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Two distinct calcitonin ( CT ) receptor ( CTR ) encoding cDNAs ( designated GC 2 and GC 10 ) were cloned and characterized from giant cell tumor of bone ( GCT ) . ^^^ Expression of all three CTR isoforms in COS cells demonstrated that GC 2 has a lower binding affinity for salmon ( s ) CT ( Kd approximately 15 nM ) than GC 10 or o hCTR ( Kd approximately 1 . 5 nM ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Binding studies of 125I labeled calcitonin ( CT ) showed that the Ag was not the CT receptor ( CTR ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| We have reported that calcitonin ( CT ) treatment induced downregulation of the CT receptor ( CTR ) in mouse osteoclast like cells ( OCLs ) . ^^^ Treatment of OCLs with activators of protein kinase A ( PKA ) mimicked the effect of CT on CTR downregulation , whereas neither activation of protein kinase C nor elevation of intracellular Ca2+ did so . ^^^ Attenuation of CT induced CTR down regulation by the competitive cAMP antagonist , RpcAMP , and high concentrations of H 7 , but not by protein kinase C specific inhibitors ( sphingosine , staurosporine , and a lower concentration of H 7 ) , suggested that the PKA pathway is primarily involved in homologous regulation of the CTR . ^^^ The changes in CTR messenger RNA confirm the findings in binding studies and demonstrate that CT treatment of OCLs results in decreased CTR synthesis through the PKA pathway . ^^^ The low concentrations of hCT that result in CTR regulation are very close to the physiological range , providing new insights into a dynamic relationship between circulating levels of CT and CTR expression in osteoclasts . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to investigate homologous regulation of the CTR , and regulation of TRAP expression in osteoclast like cells after brief treatment with salmon CT ( sCT ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| We have reported that short calcitonin ( CT ) treatment of mature mouse osteoclast like cells ( OCLs ) in culture induced prolonged down regulation of the CT receptor ( CTR ) and desensitization to CT rechallenge , at the level of adenylate cyclase activity . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Untransfected cells , cells transfected with vector alone , and CTR transfected cells not treated with CT , were unresponsive to [ Ca2+ ] e . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| We previously studied regulation of the calcitonin ( CT ) receptor ( CTR ) by glucocorticoid ( GC ) and CT in cultures of mature mouse osteoclast like cells ( OCLs ) . ^^^ The present studies were designed to examine the interaction of CT and GC in regulation of the CTR in osteoclasts and the molecular mechanisms involved . ^^^ Treatment of OCLs with 10 ( 7 ) M dexamethasone ( Dex ) increased the CTR number in a time dependent manner , whereas treatment with 10 ( 9 ) M salmon CT ( sCT ) reduced CTR number ; neither treatment changed receptor affinity . ^^^ Interestingly , transcriptional inhibition by 5 , 6 dichloro 1 beta D ribofuranosyl benzimidazole abolished the ability of CT to reduce CTR mRNA levels , suggesting that CT may act by increasing the rate of CTR mRNA decay , and that this effect requires ongoing transcription . ^^^ These results show that GC and CT influence CTR expression by distinct mechanisms and provide the basis for identification of the cellular factors involved . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Isoforms of the CT receptor ( CTR ) , with interesting functional differences , have been identified and a new form of the PTH receptor , highly specific for PTH , has been cloned . ^^^ Investigation of the homologous regulation of the CTR in osteoclasts by CT treatment of mouse marrow cultures , has shown that continuous exposure to CT results in formation of resorption competent , CTR deficient osteoclasts . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Calcitonin ( CT ) is a 32 amino acid calciotropic peptide hormone which acts on target cells via a G protein coupled seven transmembrane receptor ( CTR ) . ^^^ Upon photolysis , in the presence of CTR , the radioiodinated photoreactive CT analog ( [ Arg 11 , 18 , Lys 19 ( epsilon pBz 2 ) ] sCT ( K 19 ) ) covalently labels a membrane component of approximately 70 kDa . ^^^ We also examined the interaction of these CT analogs with a hemagglutinin ( HA ) epitope tagged CTR . ^^^ The HA CTR displayed CT binding and CT dependent cAMP stimulation identical with native CTR . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| UMR 106 06 cells predominantly express the C1a isoform of the rat calcitonin ( CT ) receptor ( CTR ) . ^^^ It was found that treatment of both cell lines with either salmon CT or human CT reduced the density of cell surface CTR in a dose and time dependent manner . ^^^ CT induced down regulation of the CTR was not mimicked by receptor independent activation of protein kinase A or protein kinase C . ^^^ These results suggest that CT induced receptor down regulation and modulation of the ability of CT to activate adenylate cyclase are inherent properties of the receptor , as they can be recapitulated in an otherwise CTR naive cell line , in which receptor expression is driven by a heterologous gene promoter . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The studies covered serum levels of total and ionized calcium ( Ca ) , parathyroid hormone ( PTH ) , calcitriol ( Ctr ) and calcitonin ( Ct ) in miners assigned to various occupational groups and suffering from deforming osteoarthrosis . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Moreover , CT and CTR mRNA levels were modified significantly during proliferation . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Autocrine regulation of CTR is also suggested by relation between CT mRNA levels and CTR mRNA . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Similar expressions of the VIP and CGRP R transcripts were observed in PTEC , whereas the CT R message was not detected . ^^^ In LT TEC , the signals for VIP R , CGRP R , and CT R transcripts were seen with a lower intensity than those in control and MG thymus . ^^^ In agreement with our molecular analysis , 1 ) VIP was the most potent peptide among VIP related peptides ( VIP > PACAP > PHM > PHV ) to stimulate cAMP production through specific type 1 VIP receptors in both PTEC and LT TEC ; 2 ) cAMP generation was induced by CGRP in PTEC and by CT in LT TEC ; 3 ) in frozen thymic sections and by flow cytometry , type 1 VIP R , CGRP R , and CT R were localized in epithelial cells ; and 4 ) in parallel , the transcription of the acetylcholine receptor alpha subunit ( the main autoantigen in MG ) was induced by CGRP and CT in PTEC and LT TEC , respectively . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Although expression of the calcitonin ( CT ) receptor ( CTR ) decreases after CT binding , there has been no evidence that it occurs at the transcriptional level . ^^^ In the present study we investigated the mechanism of CTR messenger RNA ( mRNA ) down regulation by CT in mouse cocultures of bone marrow and osteoblasts . ^^^ Moreover , competitive RT PCR analysis revealed that 1 h treatment with CT reduced the level of CTR heterogeneous nuclear RNA to 10 % in a cycloheximide independent manner . ^^^ These results suggest that CT down regulates C1a CTR mRNA expression at least in part by a transcriptional mechanism , thereby contributing to the ligand induced desensitization in cells of the osteoclast lineage . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| We investigated the mechanisms by which calcitonin ( CT ) suppresses cellular proliferation , using HEK 293 cells stably transfected with either the rat C1a CT receptor ( CTR ) or the insert negative form of the human CTR . ^^^ CT treatment of the human and rat CTR expressing cell lines resulted in a rapid and sustained induction of mRNA encoding the cyclin dependent kinase inhibitor , p21WAF1 / CIP1 , increased levels of which were maintained at least 48 h after initiation of treatment . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| In a radioligand binding assay , COS 1 cells transfected with the osteoclast CTR gene bound to [ 125I ] human CT ( hCT ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Based upon the analysis of conserved regions in G protein coupled receptors , two nonoverlapping regions in the heptahelical porcine CT receptor ( CTR ) were selected as candidate Gs interacting domains : the third intracellular loop residues 327 344 ( KLKESQEAESHMYLKAVR , P 3 region ) and the C tail residues 404 418 ( KRQWNQYQAQRWAGR , P 4 region ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| We reported previously that calcitonin ( CT ) receptor ( CTR ) mediated growth inhibition of HEK 293 cells stably transfected with the human CTR is accompanied by a rapid and sustained induction of p 21 and cell cycle arrest in G 2 . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Using mouse osteoclast like cells ( OCs ) , we have shown that short exposure to calcitonin ( CT ) resulted in prolonged reduction of CT binding by inhibiting de novo CT receptor ( CTR ) synthesis . ^^^ In this study , we examined the features of CTR down regulation and its recovery after short exposure to CT of human OCs . ^^^ These data suggest that the PKC pathway plays an important role in homologous CTR down regulation , as well as inhibition of bone resorbing activity by CT , in human OCs . ^^^ The reduced specific binding , CTR messenger RNA levels , and CT sensitive adenylate cyclase responsiveness returned to the control levels by 96 h after removal of CT . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Using mouse osteoclast like cells ( OCs ) , we have shown that treatment with glucocorticoids ( GCs ) resulted in an increase in calcitonin ( CT ) binding by enhancing CT receptor ( CTR ) gene transcription . ^^^ In this study we examined CTR regulation by GCs and the effects of GCs and CT together in human OCs . ^^^ This suggests that GCs and CTs act on CTR expression differently , consistent with our previous work using mouse OCs , in which we found that GCs increased transcription of CTR gene expression , whereas CT reduced CTR mRNA stability . ^^^ The results obtained in this study show that GC increased CTR expression and sensitivity to CT in cells of the human osteoclast lineage and provide the basis for understanding the beneficial effects of combination treatment with GCs and CTs in malignancy associated hypercalcemia . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| A similar function has been ascribed to RAMP interaction with the CT receptor ( CTR ) gene product . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Calcitonin ( CT ) , a 32 amino acid peptide hormone produced primarily by the thyroid , and its receptor ( CTR ) are well known for their ability to regulate osteoclast mediated bone resorption and enhance Ca2+ excretion by the kidney . ^^^ In this review article , CT and CTR gene transcription , signal transduction and function are addressed . ^^^ The effects of CT on the physiology of a variety of organ systems are discussed and the relationship between polymorphisms in the CTR gene and bone mineral density ( BMD ) / osteoporosis is examined . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| We concluded that the loss of CT binding in WAG / Rij rat is not related to CTR gene abnormality . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Unlike the interaction between CT and CTR , receptors for the related hormones and neuropeptides amylin , CT gene related peptide ( CGRP ) and adrenomedullin ( AM ) require one of three accessory receptor activity modifying proteins ( RAMPs ) for ligand recognition . ^^^ An amylin / CGRP receptor is revealed when CTR is co expressed with RAMP 1 . ^^^ CTR RAMP 1 , antagonized preferentially by salmon CT ( 8 32 ) and not by CGRP ( 8 37 ) , and CRLR RAMP 1 , antagonized by CGRP ( 8 37 ) , are two CGRP receptor isotypes . ^^^ Thus amylin and CGRP interact specifically with heterodimeric complexes between CTR and RAMP 1 or RAMP 3 , and CGRP and AM interact with complexes between CRLR and RAMP 1 , RAMP 2 or RAMP3 . . ^^^ The calcitonin ( CT ) receptor ( CTR ) and the CTR like receptor ( CRLR ) are close relatives within the type 2 family of G protein coupled receptors , demonstrating sequence identity of 50 % . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Present studies extended these findings by cloning cDNAs for CT and CT receptor ( CT R ) from prostate cancer cells and studying the expression of CT and CT R mRNA in prostate cancer cell lines and primary prostate tumor specimens . ^^^ The results have shown that PC 3 cells expressed CT , and not CT R , mRNA , whereas CT R , but not CT , mRNA was expressed by LNCaP cells . ^^^ Highly aggressive PC 3M cells co expressed CT and CT R mRNAs . ^^^ In situ hybridization histochemistry of archival prostate specimens has selectively localized CT and CT R mRNA in basal epithelium of benign and low grade PC specimens , and these mRNAs were not detected in either luminal epithelium or stroma . ^^^ In contrast , CT and CT R mRNA were detected throughout the luminal epithelium of moderate and high grade PC specimens . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The structure of a receptor for CT ( CTR ) was elucidated in 1991 through molecular cloning , but the structures of the receptors for the other three peptides had yet to be elucidated . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| CT scans in 65 patients were analyzed for emphysema extent and distribution using the percentage of emphysema in the lung , percentage of normal lower lung , and the CT emphysema ratio ( CTR , an index of the craniocaudal distribution of emphysema ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Interobserver variability was also significantly correlated by computed tomographic ( CT ) and magnetic resonance imaging ( MRI ) discography for disc normality ( CT r = 0 . 60 ; MRI r = 0 . 56 ) , general degeneration ( CT r = 0 . 76 ; MRI r = 0 . 71 ) , anular fissure ( CT r = 0 . 79 ; MRI r = 0 . 84 ) , and disc herniation ( CT r = 0 . 63 ; MRI r = 0 . 64 ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| We tested whether heterodimers comprised of calcitonin ( CT ) receptor lacking the 16 amino acid insert in intracellular domain 1 ( CTR ( I 1 ) ) and receptor activity modifying protein ( RAMP ) can function not only as calcitonin gene related peptide ( CGRP ) receptors but also as adrenomedullin ( AM ) receptors . ^^^ However , the apparent potency of AM , like that of CGRP , approached that of CT when CTR ( I 1 ) was co expressed with RAMP . ^^^ Moreover , the inhibitory effects of CT ( 8 32 ) were much stronger in cells co expressing CTR ( I 1 ) and RAMP than in cells expressing CTR ( I 1 ) alone . ^^^ Co expression of CTR ( I 1 ) with RAMP thus appears to produce functional CT ( 8 32 ) sensitive AM receptors . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| On the basis of these results , we conclude that the cloned receptor is the CT receptor ( CTR ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Our previous results in mouse osteoclasts suggested that calcitonin ( CT ) alters CT receptor ( CTR ) mRNA stability . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| There is a growing body of evidence indicating that calcitonin ( CT ) and its receptor ( CTR ) is involved in cell growth , differentiation and tissue development . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| CGRP , AMY and AM receptors are complexes which include a GPCR ( the CT receptor or CTR and calcitonin receptor like receptor or CRLR ) and a single transmembrane domain protein known as receptor activity modifying proteins ( RAMPs ) as well as an intracellular protein named receptor component protein ( RCP ) . ^^^ CGRP , AMY and AM receptors are complexes which include a GPCR ( the CT receptor or CTR and calcitonin receptor like receptor or CRLR ) and a single transmembrane domain protein known as receptor activity modifying proteins ( RAMPs ) as well as an intracellular protein named receptor component protein ( RCP ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Previously , we cloned a GPCR ( G protein coupled receptor ) specific to CT [ CTR 1 ( CT receptor 1 ) ] . ^^^ CTR 2 and OPR expressed in Xenopus oocytes induced calcium mediated inward chloride current in a CT and OP specific manner respectively . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| When H CTR 6 was transiently expressed in HEK 293 cells , CT failed to induce production of cAMP or to bind to the receptor . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| However , we detected CTR immunoreactivity in several additional brain areas , as the ventromedial , lateral and posterior hypothalamus , where CT binding has not yet been described . ^^^ Our detailed mapping of the CTR in the rat brain has identified CTR positive cells that will be important for subsequent characterization of behavioral functions associated with the actions of CT related peptides . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Osteoclast like cells expressed CT receptor ( CTR ) , CT receptor like receptor ( CRLR ) and RAMP 2 , but did not express RAMP 1 or RAMP 3 . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| CT receptor ( CTR ) is expressed in malignant prostate epithelium , and its activation stimulates growth of prostate cancer ( PC ) cells via activation of adenylyl cyclase and calcium / phospholipid pathways . ^^^ To identify the role of `` CT System ' ' in prostate cancer , we tested the expression of CT and CTR mRNAs in invading tumor cells of prostate cancer specimens . ^^^ The cells of primary tumors and those invading stroma co expressed CT / CTR mRNAs . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The expression of calcitonin ( CT ) and CT receptor ( CTR ) mRNA in primary prostate tumors increase with tumor progression . ^^^ Cytoprotective action of CT is mediated by CTR induced activation of Akt survivin pathway . ^^^ Since CT / CTR expression in prostate cancers increases with tumor progression , the suppression of `` CT System ' ' may enhance the effectiveness of chemotherapy . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| CT receptor ( CTR ) is expressed in malignant prostate epithelium , and its activation increases invasiveness of prostate cancer ( PC ) cells via activation of protein kinase A . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The CT R [ calcitonin ( CT ) receptor ] is expressed in the central nervous system and is involved in the regulation of food intake , thermogenesis , and behaviors . ^^^ CT R stimulating peptide 1 ( CRSP 1 ) , a potent ligand for the CT R , was recently isolated from the porcine brain . ^^^ In this study , we first confirmed that porcine CRSP 1 ( pCRSP 1 ) enhanced the cAMP production in COS 7 cells expressing recombinant rat CT R , and then we examined the central effects of pCRSP 1 on feeding and energy homeostasis in rats . ^^^ These results suggest that CRSP 1 can function as a ligand for the CT R and may act as a catabolic signaling molecule in the central nervous system . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| CLR and CTR are members of the class 2 ( family B ) G protein coupled receptors ( GPCR ) and bind calcitonin gene related peptide ( CGRP ) with similar affinities when coexpressed with RAMP 1 . ^^^ The observation that various nonpeptide CGRP receptor antagonists display a higher affinity for the CLR / RAMP1 complex than for CTR / RAMP1 provided an opportunity to investigate the molecular determinants of the differential receptor affinities of these antagonists . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The expression of human ( h ) calcitonin ( CT ) and its receptor ( CTR ) is localized to basal epithelium in benign prostates but is distributed in whole epithelium of malignant prostates . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| We and other investigators have studied the mechanism and the results indicated that desensitization to CT was closely associated with the down regulation of the CT receptor ( CTR ) . ^^^ Treatment with CT reduced concentration of cellular surface CTR and CTR mRNA expression also in human osteoclasts . ^^^ The reduced specific binding , CTR mRNA levels and CT sensitive adenylate cyclase responsiveness returned to the control levels by 96h after removal of CT . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Eight of these 24 patients with CRT findings on MR had CT abnormalities that correlated with the MR . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| This potential pitfall in CT interpretation can be avoided by taking proper measures to avoid film artifacts and by reviewing all cases on the cathode ray tube ( CRT ) display as well as the hard copy film . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| An automatic computer technique was designed to produce three dimensional ( 3D ) images of bony anatomy on a cathode ray tube ( CRT ) from computerized tomography ( CT ) data . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| In the experiment of reading CT images as a routine daily work at the CRT workstation , the average time required to analyse one CT image under a room illuminance of 100 lux was longer than that on the film viewbox . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Characteristic curves were determined for both monitors , and CRT gammas were 3 . 34 and 2 . 48 for the perceptual workstation and CT console , respectively . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| It permits CT based patient specific hyperthermia models to be constructed without tedious manual contouring on digitizing pads or CRT screens . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Whether the display medium film versus cathode ray tube ( CRT ) affects observer performance during interpretation of computed tomographic ( CT ) images is an important research issue in these times of implementation and growth of picture archiving and communications systems in radiology . ^^^ The results of this study demonstrate that current CRT display technology is adequate for enabling the primary detection of abdominal masses with CT examinations . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The bioavailability and pharmacokinetics of a new controlled release tablet ( CRT ) of naproxen ( 750 mg tablet ) have been determined , relative to an equivalent dose of conventional product ( CT ) , by a cross over study in twenty healthy volunteers . ^^^ The mean residence time and the absorption and elimination half lives of the CRT were also substantially longer than those of the CT . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The incidence , 10 year actuarial risk ( AR ) , and relative risk ( RR ) of a second malignancy developing were calculated for the 407 patients who were treated with surgery alone , 226 who were treated with surgery followed by adjuvant chemotherapy ( CT ) , 140 who were treated with surgery plus adjuvant radiation therapy ( RT ) , and 308 who received all three modalities ( CRT ) . ^^^ The AR of a subsequent cancer ( 8 . 4 % for CRT , 8 . 7 % for CT , 8 . 7 % for RT , and 11 . 7 % for surgery only patients ) did not differ significantly between treatment groups . ^^^ The overall second cancer RR was 1 . 0 % after CRT ( 95 % confidence interval [ CI ] , 0 . 4 to 2 . 0 ) , 1 . 3 % after RT ( 95 % CI , 0 . 6 to 2 . 5 ) , 1 . 6 % after CT ( 95 % CI , 0 . 9 to 2 . 6 ) , and 1 . 7 % after surgery alone ( 95 % CI , 1 . 2 to 2 . 4 ) . ^^^ The RR for acute leukemia was 16 . 7 % in the CRT group ( 95 % CI , 0 . 2 to 92 . 7 ) , 11 . 1 % in the CT group ( 95 % CI , 0 . 1 to 61 . 8 ) , 10 . 0 % in the surgery alone group ( 95 % CI , 1 . 1 to 36 . 1 ) , and 0 . 0 % in the RT group ( 95 % CI , 0 . 0 to 61 . 1 ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Recently , a 52 % incidence of abnormal computed tomography ( CT ) brain scans was found in asymptomatic children with ALL whose CNS prophylaxis consisted of CRT and either IT MTX or intrathecal cytosine arabinoside ( IT Ara C ) . ^^^ This would suggest that MTX alone in the absence of CNS leukemia or CRT is highly unlikely to produce structural CNS abnormalities detectable by CT . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Clinical evaluation of newly developed CRT viewing station : CT reading and observer ' s performance . ^^^ No significant differences in reading time existed between CRT and film in 3 of 4 readers in head CT series , and in 2 of 6 readers in body CT series . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| During the procedure , the coordinates on the patient ' s head are automatically entered into the computer and matched with those of the 3 D digitizer and CT / MR images on the CRT display . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Eighty eight percent of patients treated with chemotherapy alone had CT abnormalities , and all treated with CRT and chemotherapy had abnormal CT . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The cathode ray tube ( CRT ) as a source of `` grainy ' ' CT images . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Results were compared in terms of chemotherapy ( CT ) dose tolerated , morbidity of CRT , response rates , and surgical outcome in groups with and without PNS . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| In contrast , survivals in the 24 to 36 month group are much better than previous reports in the literature suggesting that prolonged postoperative CT may allow both a delay in CRT as well as provide improved survivals . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| METHODS AND MATERIALS : Weekly computed tomography ( CT ) scans of the pelvis ( n=51 ) and daily electronic portal images ( n=1630 ) were reviewed for eight patients who received seven field 3D CRT for prostate cancer . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Requiring the prescription dose to conform as closely as possible to the target volume raises the level of the precision and accuracy requirements generally found in conventional radiation therapy . 3D CRT treatment planning requires robust patient immobilization / repositioning systems and volumetric image data ( CT and / or MR ) acquired in the treatment position . 3D treatment planning more explicitly details the particulars of a patient ' s treatment than was ever possible with 2D treatment planning . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To analyze the failure patterns for patients with high grade astrocytomas treated with high dose conformal radiotherapy ( CRT ) using a quantitative technique to calculate the dose received by the CT or MR defined recurrence volume and to assess whether the final target volume margin used in the present dose escalation study requires redefinition before further escalation . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| For input 3D data from MRI or CT are used to display 3D images , HMD ( head mounted display ) and 3D CRT display with glass are equipped . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| MATERIAL AND METHODS : With the introduction of CT planning systems and the development of 3D conformal radiation therapy ( 3D CRT ) techniques , it has become feasible to deliver adequate doses of radiation to the target ( neck ) and at the same time saving ( parts of ) the salivary glands from doses beyond tolerance . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Hard copy ( film ) versus soft copy ( CRT ) reading performance between compressed and uncompressed images : SOLs in abdominal CT images ] . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| In order to evaluate the results of future trials without bias and to determine which group of esophageal patients will benefit from preoperative CRT , pretreatment , accurate TNM staging by CT and EUS combined with pathologic LN staging when possible will be crucial in future trimodality therapy trials for esophageal cancer . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| A few studies have been reported that CT cine viewing on the CRT is superior to film based viewing of CT images ( Seltzer et al . , Radiology 197 ( 1994 ) 119 ; Bonaldi et al . , Am . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : The objective of this study is to describe the CT patterns of radiation injury in the lungs of patients who have undergone three dimensional ( 3D ) conformal radiation therapy ( CRT ) . ^^^ MATERIALS AND METHODS : Over a 36 month period , the chest CT scans of 19 patients with non small cell lung cancer who were treated with 3D CRT were reviewed . ^^^ Knowledge of the full spectrum of these manifestations is useful in the correct interpretation of CT scans after 3D CRT . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| As reconstruction delay time of the procedures has been shortened from 1 . 0 sec . to 0 . 6 sec . , real time CT fluoroscopy monitoring is possible on the Cathode Ray Tube ( CRT ) monitor in the CT room , very closed to the patient . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| In conducting this analysis , we assumed that CRT diagnosis initially would be limited to CT and MR . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : The addition of electron density information to MR images for conformal radiotherapy ( CRT ) planning of the prostate was quantified by comparing dose distributions created on the homogeneous density and bulk density assigned images to original CT for four patients . ^^^ Dose statistics from CRT treatment plans made on CT and MR for five patient data were compared to determine if MR only treatment plans can be made . ^^^ CONCLUSIONS : Negligible differences were observed in dose distribution between CRT plans using bone+water CT number bulk assigned image and original CT . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to evaluate feasibility of reporting brain CT examinations on liquid crystal display ( LCD ) flat screen monitors vs state of the art cathode ray tube ( CRT ) monitors . ^^^ Ninety five brain CT examinations of 95 patients were displayed on Picture archiving and communications system ( PACS ) workstations equipped either with a dedicated medical imaging LCD colour monitor or on a high resolution CRT which is used for routine reporting of CT , MRI and digital radiography images in our institution . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : Fifty six consecutive patients with nonmetastatic esophageal cancer were treated with primary CRT between May 1993 and April 1999 with curative intent and subsequent surveillance with endoscopy and CT scans . ^^^ Patients with residual disease on endoscopy and / or CT 6 weeks after CRT were considered for immediate esophagectomy . ^^^ On univariate analysis , favorable prognostic factors for disease specific survival were female gender ( p = 0 . 026 ) , CT defined N ( 0 ) status ( p = 0 . 027 ) , and negative endoscopy at 6 weeks after CRT ( p < 0 . 0001 ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Almost 20 % of locally advanced tumors on initial staging CT can be resected following CRT . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| This study compared the safety and efficacy of concurrent and sequential CRT , with chemotherapy ( CT ) consisting of a cisplatin and vinorelbine regimen , in patients with locally advanced NSCLC . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : This study evaluates the utility of positron emission tomography ( PET ) , endoscopic ultrasonography ( EUS ) , and computed tomographic ( CT ) scans to predict pathologic response and survival following preoperative chemoradiation ( CRT ) in esophageal cancer . ^^^ PET , EUS , and CT were performed before ( pre ) or after ( post ) CRT and before surgical resection . ^^^ Post CRT measurements that correlated with pathologic response were : CT esophageal wall thickness ( 13 . 3 vs 15 . 3 mm , p = 0 . 04 ) , EUS mass size ( 0 . 7 vs 1 . 7 cm , p = 0 . 01 ) and PET SUV ( 3 . 1 vs 5 . 8 , p = 0 . 01 ) . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Proctoscopy , digital rectal examination ( DRE ) , computer tomography ( CT ) , endorectal ultrasound ( ERUS ) , and magnetic resonance imaging ( MRI ) can not correctly detect downstaging in rectal tumors after chemo radiation therapy ( CRT ) . ^^^ |
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| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To study the impact of fused ( 18 ) F fluoro deoxy D glucose ( FDG ) hybrid positron emission tomography ( PET ) and computed tomography ( CT ) images on conformal radiation therapy ( CRT ) planning for patients with esophageal carcinoma . ^^^ |
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| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| To report a retrospective study concerning the impact of fused 18F fluorodeoxy D glucose ( FDG ) hybrid positron emission tomography ( PET ) and computed tomography ( CT ) images on three dimensional conformal radiation therapy ( 3D CRT ) planning for patients with non small cell lung cancer ( NSCLC ) . ^^^ |
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| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : Radiotherapy ( RT ) , chemotherapy ( CT ) and combined chemo radiotherapy ( CRT ) for newly diagnosed Hodgkin ' s disease are compared with respect to SM risk , overall ( OS ) and progression free ( PFS ) survival . ^^^ CRT , 16 ( 2861 ) for CT vs . ^^^ CRT was superior to CT in terms of PFS ( OR=77 , CI 0 . 68 to 0 . 77 , p < 0 . 0001 ) . ^^^ For advanced stages ( 3 4 ) , CRT better prevents progression / relapse but CT alone seems to cause less SM . ^^^ |
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| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Impact of radiotherapy ( RT ) schedule on local response and duration of the 5 fluorouracil / cisplatin ( 5 FU / CDDP ) chemotherapy ( CT ) on m are still questioning in chemoradiotherapy ( CRT ) regimen in esophageal carcinoma . ^^^ AIM : Evaluate two RT schedules and two different CT durations by a retrospective comparison of the CRT regimens used by two centres between 1994 and 2000 . ^^^ In centre 2 ( regimen 2 ) , patients received 6 CT , 3 were concomitant to a split course RT ( 20 Gy / 10 fractions 10 3 courses ) and 3 CT were delivered after CRT . ^^^ CONCLUSION : Clinical complete response to CRT was significantly more frequent with a continuous RT whereas additional CT after CRT significantly reduced metastasis occurrence . ^^^ CRT regimen in esophageal carcinoma may be more effective using a continuous RT schedule and additional CT courses after CRT completion . . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The CT employed were : ( 1 ) CRT bacteria for MS and LB ; ( 2 ) CarioCheck Plus for MS and LB ; and ( 3 ) Dentocult SM and Mucount for MS . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| The copper transport genes CTR 1 and CTR 2 were also excluded as candidate genes for CT since they both mapped to canine chromosome region CFA11q22 . 2 22 . 5 . ^^^ |
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| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Reliability was assessed using the break point in heart rate ( HR ) linearity called the Conconi test ( CT ) and Conconi retest ( CRT ) for the noninvasive measurement of anaerobic threshold ( AT ) . ^^^ According to the results , the mean power output ( PO ) scores for the CT , CRT , and ILT were 234 . 2 + / 40 . 3 W , 232 . 5 + / 39 . 7 W , and 229 . 7 + / 39 . 6 W , respectively . ^^^ The mean HR values at the AT for the CT , CRT , and ILT were 165 . 4 + / 11 . 2 b . min , 160 . 4 + / 10 . 8 b . min , and 158 . 3 + / 8 . 8 b . min , respectively . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| Pre CRT clinicopathologic features , including age , gender , location of the tumor , clinical tumor ( cT ) classification , clinical nodal ( cN ) classification , and serum CEA levels were investigated as possible predictors for the response to preoperative CRT . ^^^ |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30988 and P01258 |
Pubmed |
SVM Score :0.0 |
| NA |
|