| Interacting proteins: P01236 and P23284 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01236 and P23284 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01236 and P23284 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01236 and P23284 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01236 and P23284 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01236 and P23284 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01236 and P23284 |
Pubmed |
SVM Score :0.59124744 |
| The interaction between CypB and PRL was subsequently confirmed in vitro and in vivo through the use of recombinant proteins and coimmunoprecipitation studies . 0.59124744^^^ |
|
| Interacting proteins: P01236 and P23284 |
Pubmed |
SVM Score :0.57480415 |
| Prolactin has been demonstrated to interact with cyclophilin B , a member of the immunophilin family of proteins . 0.57480415^^^ |
|
| Interacting proteins: P01236 and P23284 |
Pubmed |
SVM Score :0.0 |
| A yeast two hybrid screen identified an interaction between PRL and cyclophilin B ( CypB ) , a peptidyl prolyl isomerase ( PPI ) found in the endoplasmic reticulum ( ER ) , extracellular space , and nucleus . ^^^ The interaction between CypB and PRL / GH was confirmed in vitro and in vivo through the use of recombinant proteins and coimmunoprecipitation studies . ^^^ The exogenous addition of CypB potentiated the proliferation of PRL and GH dependent cell lines 18 and 40 fold , respectively . ^^^ The potentiation of PRL action by CypB was accompanied by a dramatic increase in the nuclear retrotranslocation of PRL . ^^^ Although CypB NT demonstrated levels of PRL binding and PPI activity equivalent to wild type CypB , it was incapable of mediating the nuclear retrotranslocation of PRL or enhancing PRL driven proliferation . ^^^ |
|
| Interacting proteins: P01236 and P23284 |
Pubmed |
SVM Score :0.0 |
| Recently our lab has discovered that Stat 5 activity is also regulated by its direct interaction with the retrotranslocated complex of PRL and the peptidyl prolyl isomerase cyclophilin B . ^^^ |
|