| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| Production of POMC , CRH R 1 , MC 1 , and MC 2 receptor mRNA and expression of tyrosinase gene in relation to hair cycle and dexamethasone treatment in the C57BL / 6 mouse skin . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| Hypocortisolism and alteration of pigmentation are caused by the lack of POMC derived peptides at the adrenal MC 2 receptor and the skin MC 1 receptor , respectively . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| The study shows that some parts of the MC system are highly conserved through vertebrate evolution , such as regions in POMC coding for ACTH , alpha MSH , and beta MSH , the C terminal region of AGRP , key binding units within the MC1R , MC2R , MC4R , and MC5R , synteny blocks around the MCRs , pharmacological properties of the MC2R , whereas other parts in the system are either missing , such as the MC3R and gamma MSH , or different as compared to mammals , such as the affinity of ACTH and MSH peptides to MC1R and MC4R and the anatomical expression pattern of the MCRs . . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| Male rats were subjected to rapid eye movement sleep deprivation stress and the levels of proopiomelanocortin ( POMC ) , MC3R , MC4R and MC5R transcripts in the hypothalamic pituitary adrenal axis ( HPA ) determined by real time PCR . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| The melanocortin system consists of melanocortin peptides derived from the proopiomelanocortin gene ( in particular adrenocorticotropic hormone , ACTH , and melanocyte stimulating hormones , MSH ) and five melanocortin receptor subtypes ( MC1R MC5R ) . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| The cloning of the melanocyte stimulating hormone ( MSH ) and adrenocorticotropic hormone ( ACTH ) receptors ( MC 1 R and MC 2 R , respectively ) recently has led to the identification of three additional melanocortin receptors , MC 3 R , MC 4 R , and MC 5 R . ^^^ The MC 2 receptor primarily recognizes only ACTH peptides , but the other four receptors all recognize alpha melanocyte stimulating hormone ( alpha MSH ) and potent alpha MSH agonists such as [ Nle 4 , D Phe 7 ] alpha MSH NH 2 and Ac Nle 4 c [ Asp 5 , D Phe 7 , Lys 10 ] alpha MSH ( 4 10 ) NH 2 as well as ACTH . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| The recently cloned novel MC5R gene is suggested to be a mediator of neural functions of the melanocortic peptides , such as melanocyte stimulating hormone ( MSH ) and adrenocorticotropic hormone ( ACTH ) . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| We show here that the adipocyte response to the melanocortin peptides results from the expression of both the MC 2 ( ACTH ) receptor as well as the newly discovered MC 5 receptor . ^^^ The MC 2 receptor exhibits properties similar to the ACTH receptor characterized in adrenocortical cells , coupling to activation of adenylyl cyclase with an EC 50 of approximately 1 nM . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| Evidence is provided that mRNA for ACTH ( MC 2 ) receptor and mRNAs for three obligatory enzymes of steroid synthesis including cytochromes P450scc , P450c17 and P450c21 are expressed in normal and pathologic human skin . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| Dynorphin also antagonizes the adrenocorticotropic hormone ( ACTH ; MC 2 ) receptor and an MC like receptor endogenous to COS 7 cells , but with lower efficacy . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| In contrast , the other MCR subtypes ( MC 1 R , MC 3 R , MC 4 R , MC 5 R ) recognize a common group of ligands that includes various forms of MSH as well as ACTH ; nevertheless they do exhibit important differences in ligand selectivity . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| The depressor effect observed following intravenous administration of ACTH ( 1 24 ) is thought to be due to activation of melanocortin MC 2 receptors whose location may be within the peripheral vasculature . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| Expression of ACTH receptors ( MC 2 R and MC 5 R ) in the glomerulosa and the fasciculata reticularis zones of bovine adrenal cortex . ^^^ The MC 5 receptor ( MC 5 R ) binds ACTH and alpha MSH and is more widely expressed . ^^^ In bovine adrenocortical cells in culture , ACTH stimulates MC 5 R expression in the glomerulosa and fasciculata cells . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| The receptor MC 2 ( ACTH receptor ) almost exclusively expressed in the adrenal cortex whereas MC 5 R is expressed in several organs including the adrenal cortex . ^^^ The aim of this work was to study the spatial distribution of MC 5 R among the different zones of the bovine adrenal cortex and to analyze the regulation of its expression by its own ligands , ACTH and alpha MSH and by angiotensin 2 ( AII ) . ^^^ Treatments by ACTH , alpha MSH , or AII increased the MC 5 R mRNA level in glomerulosa cells by factors 7 , 5 , and 4 . 5 , respectively . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| ACTH potently stimulates cyclase with EC 50 values that are consistent with the hypothesis that the murine MC 2 receptor , not the MC 5 receptor , mediates stress induced lipolysis via release of ACTH from the pituitary . . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| ACTH receptors exhibited a dual response since after 14 days of permanent stress MC 2 R showed a slight reduction while MC 5 R was still up regulated . . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| The ACTH and alpha MSH inhibitory effects on leptin secretion were mediated by activation of the MC 2 R and MC 5 R and were reversed by the MC R antagonists ACTH ( 11 24 ) and ACTH ( 7 38 ) . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| The results provide the first evidence that rat sympathetic ganglia express MC 2 receptor gene and are a target tissue for the peripheral actions of ACTH in response to stress . . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| The ACTH receptor ( ACTH R ) is the second member of the melanocortin ( MC 2 ) receptor family that includes five seven transmembrane G protein coupled receptors and has been shown to be predominantly expressed in the adrenal cortex . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical localization of the ACTH ( MC 2 ) receptor in the rat placenta and adrenal gland . ^^^ The adrenocorticotropic hormone ( ACTH ) acts on adrenocortical cells and promotes steroidogenesis by specific binding to the ACTH ( MC 2 ) receptor ( ACTHR ) . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| The present study addresses the regulation of cortisol release by ACTH and alpha MSH in common carp ( Cyprinus carpio ) and includes characterization of their receptors , namely , the melanocortin 2 and melanocortin 5 receptors ( MC2R and MC5R ) . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| Melanocortin receptors ( MC1R MC5R ) and their ligands ( melanocyte stimulating hormone ( MSH ) and adrenocorticotrophin hormone ( ACTH ) ) have been shown to influence physiological functions of cells and organs , including exocrine glands . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| In the present study to analyze the role of ACTH in fetal tissues and organs , we observed the expression of melanocortin type 2 ( MC 2 ) and 5 ( MC 5 ) receptors in ICR mouse embryos from E11 . 5 to E18 . 5 by immunohistochemistry . ^^^ These findings show the spatio temporal specific expression patterns of MC2R and MC5R in the mouse embryo and suggest that ACTH may be related to histogenesis and / or prenatal function of various tissues and organs via MC2R and / or MC5R . . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| No high affinity binding sites for NEI were detected on B 16 melanoma cells and there was no significant displacement of [ 1251 ] alpha MSH by MCH , NEI or NGE with MC 3 R , MC 4 R and MC 5 R expressed in COS cells . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| Previous animal studies have demonstrated that alpha melanocyte stimulating hormone ( alpha MSH ) is a sebotropic hormone in rats and that targeted disruption of melanocortin 5 receptor ( MC 5 R ) can down regulate sebum output in mice . ^^^ Molecular studies using RT PCR showed a low level of human MC 5 R expression under serum free condition but a substantial increase after treatment with NDP alpha MSH or BPE . ^^^ |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01189 and P33032 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| The cloning of the melanocyte stimulating hormone ( MSH ) and adrenocorticotropic hormone ( ACTH ) receptors ( MC 1 R and MC 2 R , respectively ) recently has led to the identification of three additional melanocortin receptors , MC 3 R , MC 4 R , and MC 5 R . ^^^ The MC 2 receptor primarily recognizes only ACTH peptides , but the other four receptors all recognize alpha melanocyte stimulating hormone ( alpha MSH ) and potent alpha MSH agonists such as [ Nle 4 , D Phe 7 ] alpha MSH NH 2 and Ac Nle 4 c [ Asp 5 , D Phe 7 , Lys 10 ] alpha MSH ( 4 10 ) NH 2 as well as ACTH . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| We show here that the adipocyte response to the melanocortin peptides results from the expression of both the MC 2 ( ACTH ) receptor as well as the newly discovered MC 5 receptor . ^^^ The MC 2 receptor exhibits properties similar to the ACTH receptor characterized in adrenocortical cells , coupling to activation of adenylyl cyclase with an EC 50 of approximately 1 nM . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| Evidence is provided that mRNA for ACTH ( MC 2 ) receptor and mRNAs for three obligatory enzymes of steroid synthesis including cytochromes P450scc , P450c17 and P450c21 are expressed in normal and pathologic human skin . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| Production of POMC , CRH R 1 , MC 1 , and MC 2 receptor mRNA and expression of tyrosinase gene in relation to hair cycle and dexamethasone treatment in the C57BL / 6 mouse skin . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| Dynorphin also antagonizes the adrenocorticotropic hormone ( ACTH ; MC 2 ) receptor and an MC like receptor endogenous to COS 7 cells , but with lower efficacy . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| The depressor effect observed following intravenous administration of ACTH ( 1 24 ) is thought to be due to activation of melanocortin MC 2 receptors whose location may be within the peripheral vasculature . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| The receptor MC 2 ( ACTH receptor ) almost exclusively expressed in the adrenal cortex whereas MC 5 R is expressed in several organs including the adrenal cortex . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| ACTH potently stimulates cyclase with EC 50 values that are consistent with the hypothesis that the murine MC 2 receptor , not the MC 5 receptor , mediates stress induced lipolysis via release of ACTH from the pituitary . . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| The results provide the first evidence that rat sympathetic ganglia express MC 2 receptor gene and are a target tissue for the peripheral actions of ACTH in response to stress . . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| Hypocortisolism and alteration of pigmentation are caused by the lack of POMC derived peptides at the adrenal MC 2 receptor and the skin MC 1 receptor , respectively . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| The ACTH receptor ( ACTH R ) is the second member of the melanocortin ( MC 2 ) receptor family that includes five seven transmembrane G protein coupled receptors and has been shown to be predominantly expressed in the adrenal cortex . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical localization of the ACTH ( MC 2 ) receptor in the rat placenta and adrenal gland . ^^^ The adrenocorticotropic hormone ( ACTH ) acts on adrenocortical cells and promotes steroidogenesis by specific binding to the ACTH ( MC 2 ) receptor ( ACTHR ) . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| In the present study to analyze the role of ACTH in fetal tissues and organs , we observed the expression of melanocortin type 2 ( MC 2 ) and 5 ( MC 5 ) receptors in ICR mouse embryos from E11 . 5 to E18 . 5 by immunohistochemistry . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| In contrast , the other MCR subtypes ( MC 1 R , MC 3 R , MC 4 R , MC 5 R ) recognize a common group of ligands that includes various forms of MSH as well as ACTH ; nevertheless they do exhibit important differences in ligand selectivity . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| Expression of ACTH receptors ( MC 2 R and MC 5 R ) in the glomerulosa and the fasciculata reticularis zones of bovine adrenal cortex . ^^^ The MC 5 receptor ( MC 5 R ) binds ACTH and alpha MSH and is more widely expressed . ^^^ In bovine adrenocortical cells in culture , ACTH stimulates MC 5 R expression in the glomerulosa and fasciculata cells . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| ACTH receptors exhibited a dual response since after 14 days of permanent stress MC 2 R showed a slight reduction while MC 5 R was still up regulated . . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| No high affinity binding sites for NEI were detected on B 16 melanoma cells and there was no significant displacement of [ 1251 ] alpha MSH by MCH , NEI or NGE with MC 3 R , MC 4 R and MC 5 R expressed in COS cells . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| The ACTH and alpha MSH inhibitory effects on leptin secretion were mediated by activation of the MC 2 R and MC 5 R and were reversed by the MC R antagonists ACTH ( 11 24 ) and ACTH ( 7 38 ) . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| Previous animal studies have demonstrated that alpha melanocyte stimulating hormone ( alpha MSH ) is a sebotropic hormone in rats and that targeted disruption of melanocortin 5 receptor ( MC 5 R ) can down regulate sebum output in mice . ^^^ Molecular studies using RT PCR showed a low level of human MC 5 R expression under serum free condition but a substantial increase after treatment with NDP alpha MSH or BPE . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| The recently cloned novel MC5R gene is suggested to be a mediator of neural functions of the melanocortic peptides , such as melanocyte stimulating hormone ( MSH ) and adrenocorticotropic hormone ( ACTH ) . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| The study shows that some parts of the MC system are highly conserved through vertebrate evolution , such as regions in POMC coding for ACTH , alpha MSH , and beta MSH , the C terminal region of AGRP , key binding units within the MC1R , MC2R , MC4R , and MC5R , synteny blocks around the MCRs , pharmacological properties of the MC2R , whereas other parts in the system are either missing , such as the MC3R and gamma MSH , or different as compared to mammals , such as the affinity of ACTH and MSH peptides to MC1R and MC4R and the anatomical expression pattern of the MCRs . . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| Male rats were subjected to rapid eye movement sleep deprivation stress and the levels of proopiomelanocortin ( POMC ) , MC3R , MC4R and MC5R transcripts in the hypothalamic pituitary adrenal axis ( HPA ) determined by real time PCR . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| The present study addresses the regulation of cortisol release by ACTH and alpha MSH in common carp ( Cyprinus carpio ) and includes characterization of their receptors , namely , the melanocortin 2 and melanocortin 5 receptors ( MC2R and MC5R ) . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| Melanocortin receptors ( MC1R MC5R ) and their ligands ( melanocyte stimulating hormone ( MSH ) and adrenocorticotrophin hormone ( ACTH ) ) have been shown to influence physiological functions of cells and organs , including exocrine glands . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| The melanocortin system consists of melanocortin peptides derived from the proopiomelanocortin gene ( in particular adrenocorticotropic hormone , ACTH , and melanocyte stimulating hormones , MSH ) and five melanocortin receptor subtypes ( MC1R MC5R ) . ^^^ |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33032 and P01189 |
Pubmed |
SVM Score :0.0 |
| NA |
|