| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.50835817 |
| Atrial natriuretic peptide ( ANP ) binds to natriuretic peptide receptor A ( NPR A ) , a membrane guanylyl cyclase , and to natriuretic peptide receptor C ( NPR C ) , which plays a role in peptide clearance . 0.50835817^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.73334509 |
| BNP was as effective as ANP in displacing 125I ANP , whereas CNP displaced label with a slightly higher IC 50 . 125I ANP binding was displaced > 95 % by c ANP , a specific ligand for natriuretic peptide C receptors ( NPR C ) . 0.73334509^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.5045608 |
| In binding studies using 125I labeled atrial natriuretic peptide ( 125I ANP ) and 125I VIP as radioligands , VIP , ANP , and the selective NPR C ligand cANP ( 4 23 ) bound with high affinity to NPR C . 0.5045608^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The presence of ANP C receptors ( clearance type ) in both cell types is indicated from the strong competition of 125I ANP specific binding by C ANF ( 4 23 ) . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| This analog , which retains many of the spatial relationships of the native molecule , binds to both ANP A and ANP C receptor subtypes , and triggers the production of cyclic GMP by ANP A . ^^^ ANP C binding of ANP [ 13 27 ] [ 1 12 ] is roughly equipotent to that of ANP itself , although the ring cleavage falls within the putative ANP C binding domain . ^^^ ANP [ 13 27 ] [ 1 8 ] , a truncated analog in which much of this binding domain has been removed , surprisingly maintains a high affinity for ANP C ; however , this peptide has lost the ability to activate the ANP A linked guanylate cyclase . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| In an effort to determine whether non cyclase containing ANP receptors , such as ANP C ( R 2 ) , are linked to any of the events triggered by ANP binding , we utilized a truncated ANP analogue , ANP ( 7 23 ) , which at low doses exhibits selectivity for the ANP C ( R 2 ) receptor . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The reduced number of receptors could reflect the down regulation of ANP C receptors in response to an elevation of plasma levels of ANP , the median value of which was 10 . 6 versus 7 . 1 pmol / L in controls ( P less than 0 . 05 ) . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Autoradiograms of 125I labeled AP 3 linked to cell membranes showed bands at 70 kDa ( ANP C receptor ) in both cell types . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| At least two types of receptors for natriuretic peptides have been reported : biologically active receptors coupled with guanylate cyclase ( atrial natriuretic peptide [ ANP ] B receptors ) and clearance receptors ( ANP C receptors ) . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Both pBNP and rBNP , as well as rat ANP 103 123 ( atriopeptin 1 ) and des [ gl 18 , ser 19 , gly 20 , leu 21 , gly 22 ] ANF 4 23 NH 2 ( C ANF 4 23 ) strongly competed for specific 125I rANF binding sites in astrocyte membranes with affinities ranging from 0 . 03 to 0 . 4 nM , suggesting that virtually all binding sites measured at subnanomolar concentrations of 125I rANF were of the ANP C ( ANF R 2 ) receptor subtype . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| In rat parotid gland , these results suggested that ANP mediates adenylate cyclase / cAMP system and consequently reduces amylase release through ANP C receptor coupled to Gi . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Interaction of a neutral endopeptidase inhibitor with an ANP C receptor ligand in anesthetized dogs . ^^^ Therefore , we infused a specific neutral endopeptidase inhibitor ( ( S ) thiorphan ) and an ANP C receptor ligand ( AP 811 ) alone or in combination into anaesthetized beagle dogs . ^^^ We conclude from these investigations , that blocking both degrading pathways of ANP with the ANP C receptor ligand AP 811 and the neutral endopeptidase inhibitor ( S ) thiorphan is more effective than inhibition of either system alone . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| C type natriuretic peptide and brain natriuretic peptide inhibit adenylyl cyclase activity : interaction with ANF R2 / ANP C receptors . ^^^ C type natriuretic peptide ( CNP ) and brain natriuretic peptide ( BNP ) are members of the natriuretic peptide family , which have been shown to interact with ANP C / ANF R 2 receptors in addition to ANP B receptor subtypes . ^^^ The present study was undertaken to investigate if the interaction of CNP and BNP with ANP C receptors results in the inhibition of adenylyl cyclase activity . ^^^ These results suggest that CNP and BNP like C ANF 4 23 interact with ANP C receptors and result in the inhibition of adenylyl cyclase activity . ^^^ On the other hand , CNP and BNP interact with the ANP C receptor , however , the interaction may be different sites or there may be two subpopulations of ANP C receptors specific for each of the peptides . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| C type natriuretic peptide suppressed evoked neurotransmitter release in the absence of guanylyl cyclase activation or adenylyl cyclase inhibition ; however , both a `` clearance ' ' ( ANP C ) receptor binding agent , des [ Gln18Ser19Gly20Leu21Gly22 ] ANF ( 4 23 ) NH 2 ( cANF ) , and pertussis toxin prevented this neuromodulatory effect . ^^^ The results suggest that C type natriuretic peptide suppressed evoked neurotransmitter efflux by binding to ANP C receptors coupled to a pertussis toxin sensitive process ; furthermore , the neuromodulatory effect of C type natriuretic peptide occurred independently of guanylyl cyclase activation or adenylyl cyclase inhibition . ^^^ The novel aspects of these findings are 1 ) neuromodulatory effects of C type natriuretic peptide , 2 ) guanylyl cyclase independent actions of C type natriuretic peptide , and 3 ) ANP C receptors mediating C type natriuretic peptide actions . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The ANP receptors present in these cells consist of a mix of ANP A and ANP B sites ( `` biological receptors ' ' ) and also ANP C sites ( `` clearance receptors ' ' ) . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| C ANF ( des [ Gln 18 , Ser 19 , Gly 20 , Leu 21 , Gly 22 ] ANP ( 4 23 ) ) a specific ligand for ANP C receptors , displaced 30 % of total binding with a lower affinity than ANF . ^^^ When CNP was incubated in the presence of 0 . 1 mumol / l C ANF to saturate ANP C receptors , the high affinity binding site vanished and maximum binding decreased to 70 % , suggesting that CNP binds with high affinity to ANP C receptors . ^^^ CNP and C ANF displaced most [ 125I ] [ Tyr ] CNP ( 1 22 ) binding with very close affinities , indicating that CNP binds primarily preglomerular vascular ANP C receptors . ^^^ Both findings suggest that [ 125I ] [ Tyr ] CNP ( 1 22 ) binds ANP C receptors exclusively . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| AP 811 , a novel ANP C receptor selective agonist . ^^^ The binding and agonist activities of AP 811 have been compared with those of other ANP analogs for the ANP A and ANP C receptors . ^^^ AP 811 binds with a high binding affinity to and is a strong agonist for the ANP C receptor , indicating that the binding and agonist sites for this receptor are the same or near each other in the ANP sequence . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Two classes of high affinity binding sites for atrial natriuretic peptide ( ANP ) were identified in a microsomal fraction from human placental artery using radioligand binding methods and des [ Gln 18 , Ser 19 , Gly 20 , Leu 21 , Gly 22 ] ANP ( 4 2 3 ) ( C ANP ) , a partially ring deleted analogue of ANP , consistent with the presence of ANP A and ANP C receptor subtypes in this tissue [ dissociation equilibrium constant ( Kd ) 58 pM , maximum binding capacity ( Bmax ) 14 fmol / mg membrane protein , and Kd 82 pM , Bmax 28 fmol / mg , respectively ] . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Several lines of evidence indicate that corneal endothelial ANP receptors are the `` clearance ' ' ( ANP C ) type . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| These proteins appear to be the hydrolytic products of the ANP C receptor expressed on the plasma membrane . ^^^ In addition to lysosomal delivery , shedding of the ANP C receptor from the cell surface was detected following incubation of cells with 125I ANP ( 99 126 ) . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| To evaluate the proportions of ANF receptor subtypes ( ANF R 1 , ANF R 2 ) , competition curves were charted in the presence of 10 ( 6 ) mol / l C ANF ( 4 23 ) , a specific ligand of ANF R 2 ( ANP C ) . ^^^ In parallel studies , the proportion of ANF R 1 ( ANP A , B ) and ANF R 2 ( ANP C ) receptors in glomeruli , calculated from competitive inhibition experiments , was 86 + / 2 and 14 + / 2 % , respectively ( P < 0 . 005 ) . ^^^ CONCLUSIONS : These results indicate that rat renal preglomerular microvessels contain a high proportion of guanylate cyclase coupled ANF R 1 ( ANP A , B ) and a low density of ANF R 2 ( ANP C ) receptors . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The presence of a large population of ANP C receptors in each type of culture is indicated by the strong competition of 125I ANP binding by the ring deleted analogue of ANP [ C ANF ( 4 23 ) ] . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Furthermore , PMA ( 100 nM , 2 or 24 h ) treatment elicited a significant decrease in the specific binding of 125I des Cys Cys ANP , an ANP C receptor selective ligand . ^^^ These data indicate that PKC modulates both guanylyl cyclase coupled and ANP C natriuretic peptide receptors in cultured astroglia . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| We investigated whether a decrease of atrial natriuretic peptide ( ANP ) receptors in the adrenal zona glomerulosa ( ZG ) could explain the marked elevation of plasma aldosterone occurring during pregnancy . 125I ANP binding was measured in competition experiments using rANP ( 1 28 ) , ANP ( 4 23 ) , a truncated analog which has high specificity for the ANP C receptor , or a combination of both . ^^^ Studies were performed to block the ANP C site . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Competition studies between 125I ANP and ANP ( atrial natriuretic peptide ) or the ring deleted analog C ANF 4 23 ( C ANF ) revealed the presence of the A type natriuretic peptide receptor ( GC A receptor ) and the ANP clearance ( ANP C ) receptor in the rat parotid membrane . ^^^ The ratio of the GC A and ANP C receptors was about 3 to 1 . ^^^ Based on the binding studies with ANP and C ANF and cGMP analysis by ANP and CNP , the natriuretic peptide receptors in the rat parotid gland were demonstrated to have a rank order on the amount of GC A receptor > GC B receptor > ANP C receptor . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| In a subsequent study , the ANP C ( clearance ) receptor agonist c ANP was microperfused into the AHA to increase extracellular concentration of endogenous ANP in AHA . c ANP reduced AHA MOPEG concentration in SHR on the basal NaCl diet but not in the other two groups . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| A novel form of type C atrial natriuretic peptide receptor ( ANP C ) was identified , characterized , and shown to be a product of alternative RNA splicing . ^^^ Sequencing of several clones of ANP C cDNA isolated from a bovine lung cDNA library revealed the presence of a new clone encoding a 536 amino acid ANP C . ^^^ The nucleotide sequence of this novel clone is very similar to that of the previously cloned ANP C which consists of 537 amino acids . ^^^ Alignment of the cDNA sequences with that of the ANP C gene indicated that the two forms of ANP C receptor arise from a single gene by alternative splicing using one donor and two closely located acceptor sites . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| ANP C glomerular receptors ( i . e . displacement of tracer binding with ANP 103 123 ) were not down regulated and had unchanged peptide binding affinity in either kidney of rats with ' malignant ' hypertension and in PHR . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| C ANF , a highly selective ligand for ANP C receptors of natriuretic peptides , did not compete for 125 1 ANP binding at concentrations up to 10nM . ^^^ These results suggest that ANP specifically binds to the ANP A receptor of 120 kDa and that there is no ANP C receptor in bovine adrenal chromaffin cells . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| ANP A and ANP B receptors are guanylyl cyclase receptors , whereas ANP C receptors are coupled to adenylyl cyclase inhibition or phospholipase C activation through inhibitory guanine nucleotide regulating protein . ^^^ Unlike other G protein coupled receptors , ANP C receptors have a single transmembrane domain and a short cytoplasmic domain of 37 amino acids , the cytoplasmic domain has a structural specificity like those of other single transmembrane domain receptors and 37 amino acid cytoplasmic domain peptide is able to exert is inhibitory effect on adenylyl cyclase . ^^^ The activation of ANP C receptor by C ANP ( 4 23 ) ( a ring deleted peptide of ANP ) and C type natriuretic peptide inhibits the mitogen activated protein kinase activity stimulated by endothelin 3 , platelet derived growth factor and phorbol 12 myristate 13 acetate . ^^^ C ANP also inhibits mitogen induced stimulation of DNA synthesis , indicating that the ANP C receptor plays a role in cell proliferation through an inhibition of mitogen activated protein kinase and suggesting that the ANP C receptor might also be coupled to other signal transduction mechanism ( s ) or that there might be an interaction of the ANP C receptor with some other signalling pathways . ^^^ This decrease is consistent with there being fewer guanylyl cyclase coupled receptors in the kidney and vasculature and selective inhibition of the ANP C receptor in the thymus and spleen . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| In zona glomerulosa cells , ribonuclease protection assay detected mRNAs for guanylate cyclase ( GC ) coupled ANP GC A and GC B receptors , and for ANP C receptors , which are not coupled to GC . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Amplification products of the expected sizes of ANP A , ANP B and ANP C receptors were detected in the inner ear . ^^^ These results suggest that natriuretic peptide family may influence the function of the inner ear through the ANP A , ANP B , and ANP C receptors . . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Angiotensin 2 modulates ANP R2 / ANP C receptor mediated inhibition of adenylyl cyclase in vascular smooth muscle cells : role of protein kinase C . ^^^ In the present studies , we have investigated the modulation of atrial natriuretic peptide ( ANP ) receptor of R 2 subtype ( ANP R2 / ANP C ) coupled to adenylyl cyclase / cAMP signal transduction system by angiotensin 2 ( angII ) . ^^^ In addition , AngII treatment stimulated the phosphorylation of Gialpha 2 but not of Gialpha 3 or ANP C receptor , as revealed by immunoprecipitation of the proteins using specific antibodies after prelabelling the cells with [ 32P ] orthophosphate . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Inhibition of atrial natriuretic peptide ( ANP ) C receptor expression by antisense oligodeoxynucleotides in A 10 vascular smooth muscle cells is associated with attenuation of ANP C receptor mediated inhibition of adenylyl cyclase . ^^^ Atrial natriuretic peptide ( ANP ) mediates a variety of physiological effects through its interaction with ANP A , ANP B or ANP C receptors . ^^^ However , controversies exist regarding the involvement of ANP C receptor and adenylyl cyclase / cAMP signal transduction systems to which these receptors are coupled in mediating these responses . ^^^ In the present studies , we have employed an antisense approach to eliminate the ANP C receptor and to examine the effect of this elimination on adenylyl cyclase inhibition . ^^^ An 18 mer antisense phosphorothioate oligodeoxynucleotide ( OH 2 ) targeted at the initiation codon of the ANP C receptor was used to examine its effects on the expression of the ANP C receptor and ANP C receptor mediated inhibition of adenylyl cyclase in vascular smooth muscle cells ( A 10 ) . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Downregulation of atrial natriuretic peptide ANP C receptor is associated with alterations in G protein expression in A 10 smooth muscle cells . ^^^ Atrial natriuretic peptide ( ANP ) receptors A and B are guanylyl cyclase receptors , whereas ANP C receptors are coupled to adenylyl cyclase through inhibitory guanine nucleotide ( Gi ) protein . ^^^ In the present studies , we have examined the regulation of ANP C receptor adenylyl cyclase signal transduction by ANP and [ des ( Gln ( 18 ) , Ser ( 19 ) , Gln ( 20 ) , Leu ( 21 ) , Gly ( 22 ) ) ANP ( 4 23 ) NH ( 2 ) ] ( C ANP ( 4 23 ) ) that interacts specifically with ANP C receptor in A 10 smooth muscle cells ( SMC ) . ^^^ However , the inhibition of adenylyl cyclase by 17 amino acid peptide ( RRNHQEESNIGKHRELR ) ( R17A ) of cytoplasmic domain of ANP C receptor was attenuated by about 50 % but was not completely abolished by C ANP ( 4 23 ) treatment . ^^^ These results indicate that C ANP ( 4 23 ) treatment of A 10 cells desensitizes ANP C receptor mediated inhibition of adenylyl cyclase which may be due to the downregulation of ANP C receptor and decreased expression of Gialpha proteins to which these receptors are coupled . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The atrial natriuretic peptide ( ANP ) C receptor is generally believed to clear ANP ; however , the ANP C receptor may serve to reduce cAMP by inhibiting adenylate cyclase . ^^^ We tested the hypothesis that part of this effect might be mediated by the ANP C receptor . ^^^ We applied either ANP or a ring deleted ANP ( C ANP ) , which only stimulates the ANP C receptor . ^^^ We conclude that agonist binding to the ANP C receptor inhibits cAMP production via a Gi protein coupled signaling system . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Modulation of ANP C receptor signaling by endothelin 1 in A 10 smooth muscle cells . ^^^ We have previously shown that pretreatment of A 10 smooth muscle cells ( SMC ) with angiotensin 2 ( Ang 2 ) attenuated atrial natriuretic peptide ( ANP ) receptor C ( ANP C ) mediated inhibition of adenylyl cyclase without altering ( 125 ) 1 ANP binding . ^^^ In the present studies , we have investigated the modulation of ANP C receptor signaling by endothelin 1 ( ET 1 ) . ^^^ Pretreatment of A 10 SMC with ET 1 for 24 h attenuated the expression of ANP C receptor by about 60 % as determined by immunoblotting which was reflected in attenuation of ANP C receptor mediated inhibition of adenylyl cyclase . ^^^ C ANP ( 4 23 ) [ des ( Gln ( 18 ) , Ser ( 19 ) , Gln ( 20 ) , Leu ( 21 ) , Gly ( 22 ) ) ANP ( 4 23 ) NH ( 2 ) ] , a ring deleted peptide of ANP that interacts specifically with ANP C receptor , inhibited adenylyl cyclase activity in a concentration dependent manner with an apparent K ( 1 ) of about 1 nM in control cells . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| We assessed the biologic activity of the 3 ANP receptors ( ANP A , ANP B , ANP C ) in the rat inner ear by measuring receptor upregulation after inner ear administration of ANPs . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Perinatal malnutrition did not significantly affect glomerular ANP receptor density , but in adrenals it decreased both B ( max ) and K ( d ) values of ANP B receptors ( biological receptors ) and increased B ( max ) of ANP C receptors ( clearance receptors ) . ^^^ ANP B ( A ) ( receptor subtype A of ANP B receptors ) receptor gene expression was not significantly affected , whereas ANP C receptor gene expression was enhanced in both adrenals and kidneys in FR 50 rats . ^^^ B ( max ) of ANP B receptors was decreased whereas B ( max ) of ANP C receptors was enhanced in both adrenals and kidneys . ^^^ Similarly , ANP C receptor gene expression was unaffected in kidneys whereas it was significantly enhanced in adrenals . ^^^ In kidneys , dehydrated FR 50 rats , like controls , upregulated ANP C receptors , but they were unable to downregulate ANP B receptors . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Modulation of ANP C receptor signaling by arginine vasopressin in A 10 vascular smooth muscle cells : role of protein kinase C . ^^^ We have previously shown that pretreatment of A 10 vascular smooth muscle cells ( VSMC ) with angiotensin 2 ( Ang 2 ) attenuated atrial natriuretic peptide receptor C ( ANP C ) mediated inhibition of adenylyl cyclase without altering [ 125I ] ANP binding . ^^^ In the present studies , we have investigated the modulation of ANP C receptor signaling by arginine vasopressin ( AVP ) . ^^^ In addition , the expression of ANP C receptor as determined by immunoblotting was also decreased by about 50 % by AVP treatment , which was prevented by GF109203X , an inhibitor of protein kinase C ( PKC ) . ^^^ The decreased expression of ANP C receptor was reflected in an attenuation of ANP C receptor mediated inhibition of adenylyl cyclase . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| In a previous study we reported that cyclic GMP ( cGMP ) selectively down regulates the atrial natriuretic peptide clearance receptor ( C ANP receptor ) in the cultured bovine pulmonary artery endothelial ( CPAE ) cell line . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| DNA sequence of the human atrial natriuretic peptide clearance receptor . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Atrial natriuretic peptide clearance receptor agonist lowers pulmonary pressure in hypoxic rats . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The amino acid sequence of the human atrial natriuretic peptide clearance receptor ( ANP C receptor ) was deduced from the nucleotide sequence of cDNA clones obtained from human placental and kidney cDNA libraries . ^^^ Isolation and functional expression of the human atrial natriuretic peptide clearance receptor cDNA . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| A general structure for the atrial natriuretic peptide clearance receptor ( ANP C receptor ) has been proposed based on hydropathicity analysis of the deduced amino acid sequence of this membrane protein ( Fuller , F . , Porter , J . ^^^ Recombinant expression of a secreted form of the atrial natriuretic peptide clearance receptor . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Atrial natriuretic peptide clearance receptor . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| A previous study at this institution demonstrated the ability to up regulate the expression of the three ANP receptors ( ANP A , ANP B , ANP C ) in response to round window injection of ANP in the rat inner ear . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The third receptor in this family , the atrial natriuretic peptide receptor type C ( ANPRC ) , is not coupled to cyclic GMP production . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Clearance of brain natriuretic peptide in patients with chronic heart failure : indirect evidence for a neutral endopeptidase mechanism but against an atrial natriuretic peptide clearance receptor mechanism . 1 . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| A recombinant vaccinia virus has been used to direct the expression of the atrial natriuretic peptide clearance receptor ( ANP C receptor ) in mammalian cell lines normally deficient in this protein . ^^^ Characterization of the atrial natriuretic peptide clearance receptor using a vaccinia virus expression vector . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| In a previous study , we reported that cyclic GMP ( cGMP ) selectively down regulates the atrial natriuretic peptide clearance receptor ( ANPC receptor ) in the vascular endothelial cells . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Effect of endopeptidase 24 . 11 inhibition and of atrial natriuretic peptide clearance receptor ligand on the response to rat brain natriuretic peptide in the conscious rat . 1 . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| A full length cDNA , encoding the mouse atrial natriuretic peptide clearance receptor ( ANP CR ) , was isolated from a mouse lung cDNA library . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Hypoxia reduces atrial natriuretic peptide clearance receptor gene expression in ANP knockout mice . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The discovery of non basic atrial natriuretic peptide clearance receptor antagonists . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : To investigate the possible immunomodulatory and regulatory functions of atrial natriuretic factor ( ANF ) and the natriuretic peptide C ( NPR C ) receptor in the control of cytokine stimulated nitric oxide production in primary cultures of human proximal tubular cells . ^^^ Paradoxically , ANF acting via the NPR C receptor also inhibits cytokine activation of the enzyme inducible nitric oxide synthase via a cyclic GMP independent mechanism . ^^^ Both of these effects were reproduced by the NPR C receptor specific ligand c ( 4 23 ) ANF . ^^^ CONCLUSIONS : These findings represent novel actions of ANF mediated via the NPR C receptor . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| CNP ( 10 ng . kg 1 . min 1 ) followed by C ANP ( 4 23 ) , a specific ligand for NPR C blockade , was infused intravenously in two groups ( both n = 7 ) of anesthetized dogs at two different doses ( 0 . 1 or 1 . 0 micrograms . kg 1 . min 1 ) to permit calculation of total metabolic clearance rate ( TMCR ) . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The sites on E 16 somites avidly bound C type natriuretic peptide [ CNP ( 1 22 ) ] as well as C ANP , a synthetic ligand that selects the C type natriuretic peptide receptor ( NPR C ) . ^^^ Most somitic binding sites had high affinity for atrial natriuretic peptide [ ANP ( 1 28 ) ] , confirming their resemblance to NPR C . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The protein has high affinities for ANP and CNP and a molecular mass of 60 70 kDa under reducing conditions , consistent with reduced NPR C . ^^^ C ANP , a synthetic ligand of NPR C , antagonized CNP ( 1 22 ) mediated cGMP production . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Photoaffinity labeling of the receptors with 4 azidobenzoyl ( AZB ) 125I ANP and competitive binding studies with 125I ANP , ANP , and atriopeptin 1 ( API ) revealed that NPR GC was detected as the predominant ANP binding protein at 0 degrees C , whereas at 37 degrees C natriuretic peptide clearance receptor ( NPR C ) was detected as the predominant protein . ^^^ AZB 125I ANP bound to NPR GC dissociated from the binding site within 5 min at 37 degrees C but not at 0 degrees C , whereas ANP bound to NPR C did not dissociate from the binding site at 0 and 37 degrees C . ^^^ The dissociated AZB 125I ANP rapidly rebound to NPR GC at 37 degrees C but not to NPR C , and the dissociated NPR GC was capable of binding . ^^^ Thus , the dissociated AZB 125I ANP rebound to NPR GC and NPR C . ^^^ Furthermore , the majority of ANP bind to NPR GC before binding to NPR C under physiological temperature . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Two sources and types of ANP affinity purified human NPR C were used to map disulfide linkages and glycosylation sites of this receptor by mass spectrometry : the extracellular domain obtained by papain cleavage of a receptor IgG fusion protein expressed in Chinese hamster ovary cells , and a baculovirus / Sf9 expressed cytoplasmic truncation mutant in which 34 of 37 cytoplasmic domain amino acids were deleted . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| All receptors had an apparent molecular mass of approximately 150 kDa , with no indication of a mammalian type NPR C at a lower apparent molecular mass . 1 nmol l 1 unlabelled rANP and 20 and 30 nmol l 1 unlabelled pCNP and C ANF , respectively , competed for 50 % of 125I ANP sites . 0 . 1 nmol l 1 rANP and pCNP and 8 nmol l 1 C ANF competitively inhibited 50 % of 125I CNP binding . ^^^ These data suggest the existence of an ANP guanylate cyclase linked receptor similar to the mammalian NPR A and an ANP / CNP receptor that may be similar to , although not structurally homologous with , the mammalian NPR C clearance receptor . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| These ANP variants were differentially selected by binding to immobilized natriuretic peptide receptor A ( NPR A ) over competing receptor C ( NPR C ) in solution . ^^^ Several of the identified mutations were combined to produce an efficiently expressed ANP analog that was as potent as wild type ANP in stimulating NPR A guanylyl cyclase activity but resistant to inactivation mediated by NPR C . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Two dimensional NMR spectroscopy has been used to characterize the solution conformation of an atrial natriuretic peptide ( ANP ) variant which is selective for the human natriuretic peptide receptor A ( NPR A ) relative to receptor C ( NPR C ) . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The natriuretic peptide system comprises at least three endogenous ligands , namely , atrial natriuretic peptide ( ANP ) , brain natriuretic peptide ( BNP ) and C type natriuretic peptide ( CNP ) , and three receptors for natriuretic peptides ( NPR ) , that is , NPR A , NPR B and clearance receptor ( NPR C ) . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| We have targeted for compromise and destruction cells within the diencephalon which bear receptors for ANP ( NRP A receptors ) , CNP ( NRP B receptors ) , or both peptides ( NPR C receptors ) using novel cytotoxin cell targeting methodology in order to determine if the neuroendocrine effects of these two peptides are exerted on similar cell systems . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| These studies were designed to characterize the atrial natriuretic peptide ( ANF ) receptor subtypes [ guanylyl cyclase natriuretic peptide receptors ( NPR A , NPR B ) and NPR C ] in lungs of normal hamsters and to evaluate alterations in receptor kinetics in genetic cardiomyopathy ( CMO ) , a model of human congestive heart failure . ^^^ Cross linking and competitive binding receptor assays using 125I labeled human ANF showed that lung membranes exhibit NPR , mainly guanylyl cyclase NPR A and clearance NPR C receptors . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Although many studies have examined the effects of administering natriuretic peptide receptor C ( NPR C ) ligands and endopeptidase 24 . 11 ( EP 24 . 11 ) inhibitors on clearance and bioactivity of atrial natriuretic peptide ( ANP ) , none have systematically compared their effects on the endogenous levels of both ANP and brain natriuretic peptide ( BNP ) under physiological conditions . ^^^ Accordingly , we examined the hemodynamic , hormonal , and renal actions of an EP 24 . 11 inhibitor , SCH 32615 , and an NPR C ligand , C ANP ( 4 23 ) , both alone and in combination in eight normal conscious sheep . ^^^ NPR C blockade and EP 24 . 11 inhibition induce similar rises in plasma ANP , BNP , and guanosine 3 ' , 5 ' cyclic monophosphate ( cGMP ) . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Binding studies were performed on membranes of COS 1 cells transfected with expression plasmids for either rat natriuretic peptide receptor ( NPR ) A , rat NPR B , or bovine NPR C . 125I ANP ( 99 126 ) was used as a ligand to assess the binding characteristics of NPR A and C , and 125I Tyr ( O ) CNP was used to study NPR B . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The natriuretic peptide clearance receptor ( NPR C ) binds atrial natriuretic peptide , brain natriuretic peptide and C type natriuretic peptide with high affinity . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| A second type of receptor mediates the clearance of ANP ( the clearance receptor , NPr C ) . ^^^ CONCLUSIONS : Fasting exerts a tissue specific and gene specific suppression of NPr C gene expression in adipose tissue that appears to be accompanied by an increased biological activity of ANP . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Binding of [ 125I ] ANP was not displaced by CNP or by C ANP ( 4 23 ) , a specific ligand of clearance receptors ( NPR C ) , and thus occurred mainly via NPR A . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| In the renal glomeruli , the maximal binding capacity ( Bmax ) of the heterogeneous atrial natriuretic peptide ( ANP ) receptor population ( NPR A and NPR C ) was significantly lower in EtOH treated SHR and WKY rats compared with water treated controls . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| ANP ( 10 ( 9 ) and 3 . 10 ( 9 ) ) , which binds to NPR A and NPR C , dilated preglomerular vessels and constricted efferent arterioles similarly to that found in previous studies . ^^^ A specific ligand of NPR C , C ANP ( des [ Gln 18 , Ser 19 , Gly 20 , Leu 21 , Gly 22 ] ANP 4 23 NH 2 , 10 ( 9 ) to 10 ( 7 ) ) was devoid of vascular effects . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The aim of the present study was to investigate the role of NPR C , the other receptor for atrial natriuretic peptide , in increased salt sensitivity of blood pressure . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Natriuretic peptide system consists of three endogenous ligands , ANP ( atrial natriuretic peptide ) , BNP ( brain natriuretic peptide ) and CNP ( C type natriuretic peptide ) , and three receptor subtypes , natriuretic peptide receptor ( NPR ) A or guanylate cyclase ( GC ) A and NPR B or GC B and C receptor ( NPR C ) . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| In contrast , NPR C specific ligands alone had no effect on cell growth but enhanced growth inhibition when co administered with ANP and CNP . ^^^ Once again , NPR C specific ligands alone had no effect but enhanced the effects of ANP . ^^^ To examine a potential mechanism for the controversy concerning the NPR C , we investigated the autocrine expression of ANP and CNP by VSMC and found that mRNA encoding both peptides could be detected by RT / PCR . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The synthetic hBNP variant S19R had a 265 fold improved NPR A binding over NPR C , analogous to the atrial natriuretic peptide ( ANP ) specificity mutation G16R . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The effect of ANP was mediated via the guanylate cyclase coupled NPR A as shown by experiments employing stable cGMP analogs , the NPR A antagonist HS 142 1 , LY 83583 , a cGMP inhibitor as well as C ANF , a specific ligand of the NPR C . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Thus , most ANP receptors in eel gill are NPR C and NPR D , but a small number of the NPR B type are also present in FW eels . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| In this study we evaluated plasma atrial natriuretic peptide ( ANP ) and gene expression of biologically active type A natriuretic peptide receptor ( NPr A ) and clearance natriuretic peptide receptor ( NPr C ) in adipose tissue of obese hypertensive and obese normotensive patients . ^^^ CONCLUSIONS : Our data suggest that in obese hypertensives compared to obese normotensives , the lower NPr A : NPr C ratio might determine decreased biological activity and / or an increased clearance of natriuretic peptide in adipose tissue , suggesting that the natriuretic peptide and its receptor system may be important in obesity related hypertension where ANP levels are lower . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The lung is rich in atrial natriuretic peptide binding sites , and the majority of them are considered to be the natriuretic peptide clearance receptor ( NPR C ) . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Systemic clearance of atrial natriuretic peptide ( ANP ) is in part due to neutral endopeptidase ( NEP ) proteolysis and natriuretic peptide receptor C ( NPR C ) mediated endocytosis . ^^^ Analogs of ANP selective for NPR A and / or resistant to NEP may have increased activity in those tissues where NPR C and NEP are coexpressed with NPR A . ^^^ The analog of ANP termed vANP ; [ ( R3D , G9T , R11S , M12L , G16R ) ANP ] is selective for human NPR A with at least 10 , 000 fold reduction in affinity for human NPR C . ^^^ The remaining ANP binding sites can be occupied with the NPR C selective ligand cANP ( 4 23 ) . ^^^ These data strongly suggest that only two classes of ANP receptor are present in these membrane preparations , NPR A and NPR C . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| In cells from both species radioligand studies using 125I ANP suggested that the majority of binding sites ( > 85 % ) were non guanylyl cyclase linked ( NPR C subtype ) . ^^^ ANP ( 10 ( 11 ) to 10 ( 6 ) M ) , a NPR C ligand , C ANF 4 23 ( 10 ( 11 ) to 10 ( 6 ) M ) and zaprinast alone had no significant effect on either basal or serum stimulated DNA synthesis or fibroblast number . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Receptor subtypes were characterized by competition with des [ Gln 18 , Ser 19 , Gly 20 , Leu 21 , Gly 22 ] ANP ( 4 23 ) ( C ANP ) , a specific ligand for the clearance receptor ( NPR C ) . ^^^ These results indicate that ANP binding sites in the epithelium of the tongue and hard palate are mainly clearance receptors ( NPR C ) but biological receptors ( NPR A and / or NPR B ) with GC activity are also present , and suggest that ANP may have a role in the proliferation of the oral epithelial cells , especially in the tongue and hard palate . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| We then demonstrated in the rat that fasting exerts a tissue specific and gene specific suppression of NPr C gene expression in adipose tissue that appears to be accompanied by an increased biological activity of ANP . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NPR C transcript was not detectable by RT PCR in FRTL 5 cells cultured in high TSH medium , suggesting that the ANF binding sites increased by TSH are not NPR C . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Competitive inhibition studies showed that 4 23 C ANP , which is specific of clearance receptors ( NPR C ) , displaced 90 % of the maximum fraction bound , suggesting the predominance of NPR C in both cell lines . ^^^ Increased expression of NPR C in D NOD cells was associated with an increase of ANP internalization rate at 37 degrees C , indicating that these receptors were functional . ^^^ CONCLUSIONS : These studies demonstrate that the constitutive overexpression of NPR C in D NOD mesangial cells is associated with a decreased response of cGMP to ANP or CNP treatment . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| By RT PCR and DNA sequencing , we demonstrated that the CE and NPE cells express mRNA for ( 1 ) ANP ; ( 2 ) BNP ; ( 3 ) NPR A , NPR B , and NPR C receptors ; and ( 4 ) the neutral endopeptidase 24 . 11 . ^^^ C ANP 4 23 elicited an inhibitory effect ( 30 37 % ) on basal levels of cAMP in NPE cells and on forskolin NPE treated cells , indicative that the NPR C receptor is functional in these cells . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Specific ( 125 ) 1 rANP binding sites were observed on glomeruli and blood vessels , but little if any binding was observed over regions corresponding to the renal tubules . ( 125 ) 1 rANP binding in tissue sections and / or isolated membranes was completely displaced in the presence of 1 microM rat ANP , frog ANP , and porcine C type natriuretic peptide ( membranes only ) ; however , residual binding remained after incubation with 1 microM of the NPR C ligand , C ANF , indicating the presence of two distinct binding sites . ^^^ This study provides evidence that the kidney of B . marinus contains both NPR C and NPR GC and that the glomerulus is potentially the principal site of ANP regulation in the kidneys . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| On the other hand , binding of 125I ANF increased with age , and the higher binding at 4 days was mainly due to increased density of the clearance receptor C ( NPR C ) , and at 22 days due to increased natriuretic peptide receptor A ( NPR A ) . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Unresponsiveness of aldosterone secreting adenomas ( aldosteronomas ) to ANP in vitro and in vivo , might be due to reduced expression of the biologically active natriuretic peptide receptor type A ( NPr A ) and / or increased expression of the clearance receptor for natriuretic peptides ( NPr C ) . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The natriuretic peptide ( NP ) system consists of three types of hormones [ atrial NP ( ANP ) , brain or B type NP ( BNP ) , and C type NP ( CNP ) ] and three types of receptors [ NP receptor ( R ) A , NPR B , and NPR C ] . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Freshly isolated cells expressed mRNA coding for ANF , BNP , and the NPR C . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Atrial natriuretic peptide ( ANP ) , the selective NPR C ligand cANP ( 4 23 ) , and vasoactive intestinal peptide ( VIP ) inhibited ( 125 ) 1 ANP and ( 125 ) 1 VIP binding to muscle membranes in a pattern indicating high affinity binding to NPR C . ^^^ Interaction of VIP with NPR C was confirmed by its ability to inhibit ( 125 ) 1 ANP binding to membranes of NPR C transfected COS 1 cells . ^^^ Atrial natriuretic peptide ( ANP ) , the selective NPR C ligand cANP ( 4 23 ) , and vasoactive intestinal peptide ( VIP ) inhibited ( 125 ) 1 ANP and ( 125 ) 1 VIP binding to muscle membranes in a pattern indicating high affinity binding to NPR C . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| We compared plasma ANP concentrations , cGMP concentrations , and natriuretic peptide receptor ( NPR ) A mRNA and NPR C mRNA expression in rat lung 3 h after pneumonectomy ( n=5 ) or a sham operation ( n=5 ) . ^^^ These findings suggest that changes in pulmonary ANP and NPR C expression may contribute to the development of PPE in the remaining lung in the acute phase following pneumonectomy . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The recent development of genetic mouse models presenting life long alterations in expression of the genes for atrial natriuretic peptide ( ANP ) or its receptors ( NPR A , NPR C ) has uncovered a physiological role of this hormone in chronic blood pressure homeostasis . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| However , the metabolic clearance of these hormones are dependent on similar systems , natriuretic peptide clearance receptor ( NPR C ) and neutral endopeptidase 24 . 11 ( NEP ) , suggesting a possible interaction between ANP and BNP on metabolic clearance . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The distribution and nature of 125I atrial natriuretic peptide binding sites have been examined in the brain and pituitary gland of the toad , Bufo marinus , using tissue section autoradiography , affinity cross linking and electrophoresis , guanylyl cyclase assays and molecular analysis of natriuretic peptide receptor C ( NPR C ) and NPR GC mRNA expression . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| After oral administration of carvedilol ( low dose group : 2 mg / kg / day , group C 2 ; high dose group : 20 mg / kg / day , group C 20 ) for 1 week , plasma rat atrial NP ( r ANP ) , atrial mRNA levels of ANP , left ventricular mRNA of brain NP ( BNP ) , NP receptor A and NP receptor C ( NPR C ) ( as a clearance receptor ) were measured . ^^^ ANP and BNP mRNA levels were significantly increased and NPR C was significantly down regulated in group C 2 ( 151 + / 7 , 120 + / 8 and 78 + / 7 % , respectively , vs . group 5 ) and group C 20 ( 164 + / 8 . 133 + / 7 and 72 + / 8 % , respectively , vs . group 5 ) compared with group 5 ( all p < 0 . 01 ) . ^^^ This effect was closely related to the upregulation of ANP and BNP mRNA expression , and the down regulation of NPR C mRNA expression in the heart . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Mesangial cells from nonobese diabetic ( NOD ) mice ( D NOD ) that develop diabetes at 2 4 mo express an increased density of atrial natriuretic peptide ( ANP ) clearance receptors [ natriuretic peptide C receptor ( NPR C ) ] and produce less GMP in response to ANP than their nondiabetic counterparts ( ND NOD ) . ^^^ These studies suggest that EGF potentiates the ANP glomerular effects in diabetes by inhibition of its degradation by mesangial NPR C via a mechanism involving AP 1 . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| However , higher concentrations of ANP and CNP , and low concentrations of des [ Gln ( 18 ) , Ser ( 19 ) , Gly ( 20 ) , Leu ( 21 ) , Gly ( 22 ) ] ANP ( 4 23 ) NH ( 2 ) ( desANP ( 4 23 ) ) ( analog for NPR C receptor ) exerted antiproliferative actions in three of the cell lines . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Dietary salt supplementation selectively downregulates NPR C receptor expression in kidney independently of ANP . ^^^ We have previously demonstrated organ selective potentiation of ANP in the pulmonary circulation of hypoxia adapted animals by local downregulation of its clearance receptor ( NPR C ; Li H , Oparil S , Meng QC , Elton T , and Chen Y F . ^^^ These findings suggest that selective downregulation of NPR C in the kidney in response to dietary salt supplementation may contribute to local elevation in ANP levels and may be functionally significant in attenuating the development of salt sensitive hypertension . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Because some biological activities of ANP have been reported to be mediated via an NPR C mediated inhibition of adenylate cyclase , we determined cAMP levels . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Significant increases in retracted cell number were induced by ANF and CNP , but not the NPR C specific ring deleted ANF analog , C ANF ( 4 23 ) , during a 15 day treatment . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression of the various isoforms of atrial , brain , and C type natriuretic peptide ( ANP , BNP , CNP ) and different subtypes of natriuretic peptide receptor A , B , and C ( NPR A , NPR B , NPR C ) was determined in the kidney and the thoracic aorta by reverse transcription polymerase chain reaction . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Initially , ANP , NPR A and NPR C cDNAs ( partial for receptors ) were cloned and sequenced , and were shown to have high homology with those of rat and mouse . ^^^ Using a semi quantitative multiplex PCR technique , the expression of cardiac ANP mRNA and renal ANP , NPR A , and NPR C mRNA was determined in 7 and 14 day water deprived hopping mice , in parallel with control mice ( access to water ) . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| However , stimulating NPR C receptor with des ( Gln ( 18 ) , Ser ( 19 ) , Gly ( 20 ) , Leu ( 21 ) , Gly ( 22 ) ) ANP fragment 4 23 amide ( C ANP ) also increased hepatocyte tolerance to hypoxia . ^^^ The inhibition of phospholipase C or PKC by U 73122 and chelerythrine , respectively , significantly reduced ANP cytoprotection , indicating that ANP interaction with NPR C receptors also contributed to cytoprotection . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Atrial natriuretic peptide ( ANP ) is present in gastric mucosa and preferentially binds to two subtypes of natriuretic peptide receptors ( NPR ) , NPR A and NPR C . ^^^ Atrial natriuretic peptide ( ANP ) is present in gastric mucosa and preferentially binds to two subtypes of natriuretic peptide receptors ( NPR ) , NPR A and NPR C . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Human macrophages isolated by peripheral blood mononuclear cells and THP 1 monocytes , which were shown to express all three natriuretic peptide receptors ( NPR A , NPR B , and NPR C ) , were treated with physiological concentrations of ANP . ^^^ Moreover , all assessed ANP effects seem to be mediated by the NPR C . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The selective natriuretic peptide receptor C ( NPR C ) receptor agonist cANP ( 4 23 ) mimicked ANF response in a dose dependent fashion . ^^^ When the intracellular signaling coupled to NPR C receptors was investigated in isolated pancreatic acini , results showed that ANF did not modify basal or forskolin evoked cAMP formation , but it dose dependently enhanced phosphoinositide hydrolysis , which was blocked by the selective PLC inhibitor U 73122 . ^^^ Present findings support that ANF exerts a stimulatory effect on pancreatic exocrine secretion mediated by NPR C receptors coupled to the phosphoinositide pathway . . ^^^ Atrial natriuretic factor stimulates exocrine pancreatic secretion in the rat through NPR C receptors . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to investigate the effects of C type natriuretic peptide ( CNP ) on pH ( 1 ) , cGMP / cAMP and expression of atrial natriuretic peptide receptor ( NPR A ) , brain natriuretic peptide receptor ( NPR B ) and C type natriuretic peptide receptor ( NPR C ) , in HTM cells . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Water deprivation increased the B ( max ) of glomerular binding sites for ANP ( 1 28 ) and C type natriuretic peptide ( CNP ) ( 1 22 ) without modifying their affinity , an effect that was prevented in the presence of C atrial natriuretic factor ( C ANF ) , suggesting that natriuretic peptide receptor C ( NPR C ) binding sites might be enhanced . ^^^ In addition , using affinity cross linking studies we have observed that water deprivation increases the expression of the 67 kDa NPR C like protein , and HS 142 , which binds to NPR A and the 77 kDa NPR C like but not the 67 kDa protein , reduced ligand internalization without affecting cAMP inhibition by ANP ( 1 28 ) . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| In contrast , ( 125 ) 1 ANP purified from medium bathing cells expressing NPR C , a receptor known to internalize natriuretic peptides , was degraded . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : Quantitative `` real time ' ' RT PCR demonstrated that the mRNA expression levels of ANP , BNP and the NP metabolizing NPR C receptor were both markedly increased in human failing hearts . ^^^ Reversal of cardiomyocyte hypertrophy during LVAD support was accompanied by normalization of ANP , BNP and NPR C mRNA levels and a significant recovery of GC A responsiveness to ANP . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The natriuretic peptide type C receptor ( NPR C ) is not involved , since the specific analogous 100 nM 4 23 ANF amide has no effect on renal DA uptake and does not alter the effects of 100 nM ANF . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| At the same time , all assessed ANP effects were mediated by NPR C receptors . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The result suggested that the effect of exercise on renal NPRs mRNA expression was mainly on the modulation level of NPR C mRNA , it could reduce the clearance rate of ANP , increase the level of ANP , and enhance the biological effect of ANP on the kidney and regulative action of kidney in exercise . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Isatin itself antagonised not only natriuretic peptide receptor type A ( NPR A ) ( ANP stimulation of guanylyl cyclase ) but also NPR C ( ANP and CNP mediated inhibition of adenylyl cyclase ) signalling . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| ANP , BNP , CNP , as well as C ANP ( 4 23 ) , a ring deleted peptide that specifically interacts with NPR C receptor inhibit adenylyl cyclase activity through Gi protein . ^^^ In addition , C ANP ( 4 23 ) also stimulates phosphatidyl inositol ( PI ) turnover in vascular smooth muscle cells ( VSMC ) which is attenuated by dbcAMP and cAMP stimulatory agonists , suggesting that NPR C receptor mediated inhibition of adenylyl cyclase and resultant decreased levels of cAMP may be responsible for NPR C mediated stimulation of PI turnover . ^^^ Furthermore , the activation of NPR C receptor by C ANP ( 4 23 ) and CNP inhibits the mitogen activated protein kinase activity stimulated by endothelin 3 , platelet derived growth factor , phorbol 12 myristate 13 acetate , suggesting that NPR C receptor might also be coupled to other signal transduction system or that there may be an interaction of the NPR C receptor and some other signaling pathways . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Further , the ANP clearance receptor NPR C , but not the biological active NPR A and NPR B receptors , is downregulated in hypoxia adapted lung . ^^^ The reductions in NPR C in the hypoxic lung retard the clearance of ANP and allow more ANP to bind to biological active NPR A and NPR B in the pulmonary circulation , relaxing preconstricted pulmonary vessels , reducing pulmonary arterial pressure , and attenuating the development of hypoxia induced pulmonary hypertension and vascular remodeling . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| To investigate effects of natriuretic peptides in the gallbladder , we measured relaxation of isolated human and guinea pig gallbladder strips caused by natriuretic peptides , including C type natriuretic peptide ( CNP ) , brain natriuretic peptide ( BNP ) and ANP , as well as des [ Gln 18 , Ser 19 , Gly 20 , Leu 21 , Gly 22 ] ANP ( 4 23 ) amide ( cANP ( 4 23 ) ) , a selective natriuretic peptide receptor C ( NPR C ) agonist . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| VNP binding was displaced by incubation in the presence of 1 microM ANP ( 1 28 ) , CNP ( 1 22 ) and C ANP , which suggests that VNP mostly binds to NPR C . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| A putative clearance receptor , NPR C , is believed to regulate cardiac levels of ANP and BNP . ^^^ Aortic banding increased left ventricular expression of NPR A and NPR C mRNA by 110 % ( P < 0 . 001 ) and 520 % ( P < 0 . 01 ) , respectively , after 8 wk ; as expected , it also increased the expression of ANP and BNP mRNAs . ^^^ Although increased gene expression does not necessarily convey a higher concentration of the protein , the data suggest that pressure overload is accompanied by upregulation of not only ANP and BNP but also their receptors NPR A and NPR C in the left ventricle . . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Water deprivation for 3 , 7 , 14 days had a variable effect on the mRNA expression of ANP , CNP , NPR A , NPR B , and NPR C , and a uniform down regulation was not observed . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The NPR C agonist c ANF [ des ( Gln 18 , Ser 19 , Gln 20 , Leu 21 , Gly 22 ) ANF ( 4 23 ) NH 2 ] did not suppress GABAA currents . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The ob / ob mice with type 2 diabetes displayed highly significant increases of the cardiac mRNA expression of NPR B and NPR C while the expression levels of NPR A , ANP , BNP , and CNP mRNA were similar in ob / ob mice and controls . ^^^ The ANP and NPR C mRNA expressions were only altered after 3 weeks , whereas BNP , CNP and NPR A mRNA expressions were not altered in STZ treated mouse hearts at any of the time points . ^^^ |
|
| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The C type NPR ( NPR C ) is responsible for clearance of NP hormones from the circulation , and displays a cross reactivity for all NP hormones ( ANP , BNP , and CNP ) , in contrast to other NPRs , which are more restricted in their specificity . ^^^ In order to elucidate the structural determinants for the binding specificity and cross reactivity of NPR C with NP hormones , we have determined the crystal structures of the complexes of NPR C with atrial natriuretic peptide ( ANP ) , and with brain natriuretic peptide ( BNP ) . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| To explore the possibility that CR lowers BP through an ANP receptor dependent mechanism that is independent of its effect on sodium retention , we measured the cardiovascular parameters of mice deficient in the ANP receptor ( NPR 1 ( / ) ) or the ANP clearance receptor ( NPR 3 ( / ) ) . ^^^ Furthermore , circulating ANP levels and data from NPR 1 ( / ) and NPR 3 ( / ) mice suggest that the ANP pathway may not be involved in the cardiovascular response to CR . . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| In initial studies , we determined that atrial natriuretic peptide ( ANP ) is not a suitable ligand for labeling the NPRB : in tissues reported to contain NPRB transcripts , CNP did not inhibit [ 125I ] ANP binding except to NPRC sites . ^^^ Therefore , to visualize the NPRB we used 125I [ Tyr ( o ) ] CNP as a radioligand with an excess of NPRC blocking peptide : C ANP . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| We investigate the interaction of atrial natriuretic peptide ( ANP ) brain natriuretic peptide ( BNP ) and C type natriuretic peptide ( CNP ) with their receptors ( NPRA , NPRB and NPRC ) , as well as the proportion and localization of those receptors in the rat ciliary body . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The half life of [ 125I ] ANP in the circulation of homozygotes lacking NPRC is two thirds longer than in the wild type , although plasma levels of ANP and BNP in heterozygotes and homozygotes are close to the wild type . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : A common ' ancestral ' C ( 55 ) variant of the NPRC P 1 promoter is associated with lower ANP levels and higher SBP and MBP in obese hypertensives . ^^^ The C ( 55 ) variant , in the presence of increased adiposity , might reduce plasma ANP through increased NPRC mediated ANP clearance , contributing to higher blood pressure . . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| In cultured bovine aortic endothelial cells , VEGF significantly stimulated extracellular signal regulated protein kinase activity and phosphorylation , which was inhibited 60 % by coincubation with ANP or a natriuretic peptide clearance receptor specific ligand ( NPRC ) , C type NAP ( 4 23 ) [ C ANP ( 4 23 ) ] . ^^^ A specific NP guanylate cyclase ( GC ) receptor antagonist , HS 142 1 , blocked the actions of ANP [ but not those of C ANP ( 4 23 ) ] , supporting the involvement of both GC and NPRC receptors . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| The natriuretic peptide receptor C ( NPRC ) specific agonist C ANF ( 4 23 ) ( 12 . 5 and 125 pmol min ( 1 ) ) did not alter splenic intravascular pressure or pre / post capillary resistance . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Atrial natriuretic peptide receptor C ( NPRC ) has a short cytoplasmic domain that lacks guanylyl cyclase activity . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| AIM : The roles of the atrial natriuretic peptide ( ANP ) gene and the clearance receptor of the ANP ( NPRC ) gene in hypertensive groups of African ancestry are unclear . ^^^ The aim of the present study was to assess the relationship between both ANP and NPRC gene polymorphisms and hypertension in Black South Africans . ^^^ CONCLUSIONS : The results of the present study suggest that the ANP , but not the NPRC locus contributes to BP in subjects of African ancestry . . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Given the expression pattern of natriuretic peptides ( NPs ) and their receptors , natriuretic peptide receptor A ( NPRA ) , natriuretic peptide receptor B ( NPRB ) and natriuretic peptide receptor C ( NPRC ) in the human retina has not yet been established , the present study was designed to determine ANP , BNP and CNP gene expression and localize the mature peptides in this tissue . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| One and 3 months after the onset of diabetes , the expression of ANP mRNA and that of its receptors ( NPRA , NPRB , NPRC ) and the immunoreactive ANP was quantified in retinal tissue by quantitative real time reverse transcription polymerase chain reaction ( RT PCR ) and radioimmunoassay , respectively . ^^^ However , 3 months after the onset of diabetes , significantly diminished ANP and NPRC mRNA levels were detected in the retina of diabetic rats compared to controls , while NPRA , NPRB mRNA levels remained unchanged . ^^^ CONCLUSIONS : The downregulation of ANP and NPRC in retinas of diabetic rats suggests a role for this peptide in experimental diabetic retinopathy . ^^^ Further studies should address the possible involvement of the ANP / NPRC system in the pathophysiology of diabetic retinopathy . . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| A specific analogue of ANP , C ANP ( 4 23 ) , which binds to the natriuretic peptide receptor C ( NPRC ) , had no effect in either FSH induced or spontaneous oocyte maturation . ^^^ All these results suggest that ANP is a multifunctional regulator of FSH and forskolin on pig CEO maturation by two signalling mechanisms : one is via a cGMP / PKG pathway , the other is via NPRC receptors in cumulus cells and the activation of the PT sensitive Gi protein ( s ) . . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| Treatment with C ANP ( 4 23 ) , an analogue of ANP and specific binder to natriuretic peptide receptors C ( NPRC ) , had no significant effect on the acrosome reaction . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| While the levels of natriuretic peptide receptors C ( NPRC ) mRNA were low with no obvious change among different oviductal phases , the levels of ANP mRNA were high in oviduct ( OT ) 1 , OT 3 and OT 5 , but were very low in OT 2 . ^^^ Both C ANP ( 4 23 ) , a selective ligand of NPRC , and caffeine had no effect on the acrosome reaction . ^^^ |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17342 and P01160 |
Pubmed |
SVM Score :0.0 |
| NA |
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