| Interacting proteins: P01106 and Q9Y265 |
Pubmed |
SVM Score :0.0 |
| Here , we show that MYC associates with TIP 60 and recruits it to chromatin in vivo with four other components of the TIP 60 complex : TRRAP , p 400 , TIP 48 and TIP 49 . ^^^ |
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| Interacting proteins: P01106 and Q9Y265 |
Pubmed |
SVM Score :0.0 |
| TIP 49 and TIP 48 are complexed with c Myc in vivo , and binding is dependent on a c Myc domain essential for oncogenic activity . ^^^ A missense mutation in the TIP 49 ATPase motif acts as a dominant inhibitor of c Myc oncogenic activity but does not inhibit normal cell growth , indicating that functional TIP 49 protein is an essential mediator of c Myc oncogenic transformation . ^^^ |
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| Interacting proteins: P01106 and Q9Y265 |
Pubmed |
SVM Score :0.0 |
| We have previously reported the identification and functional characterization of four different c Myc cofactors : TRRAP , hGCN 5 , TIP 49 , and TIP 48 . ^^^ |
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| Interacting proteins: P01106 and Q9Y265 |
Pubmed |
SVM Score :0.0 |
| We describe an RPM 1 interacting protein that is an ortholog of TIP49a , previously shown to interact with the TATA binding protein ( TBP ) complex and to modulate c myc and beta catenin mediated signaling in animals . ^^^ |
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| Interacting proteins: P01106 and Q9Y265 |
Pubmed |
SVM Score :0.0 |
| TIP 49 , but not TRRAP , modulates c Myc and E2F1 dependent apoptosis . ^^^ Although TRRAP and TIP 49 are both essential for transformation , TIP 49 modulates c Myc mediated apoptosis whereas disruption of TRRAP activity has no apparent effect on apoptosis . ^^^ |
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| Interacting proteins: P01106 and Q9Y265 |
Pubmed |
SVM Score :0.0 |
| TIP 49 , an ATPase previously implicated as a cofactor for oncogenic transformation by c Myc , has been shown to bind to beta catenin . ^^^ |
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| Interacting proteins: P01106 and Q9Y265 |
Pubmed |
SVM Score :0.0 |
| NA |
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