| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.60259616 |
| Recombinant mouse CRD BP binds specifically to c myc CRD RNA in vitro and reacts with antibody against human CRD BP . 0.60259616^^^ |
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| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| IMP 1 is orthologous to the chicken zipcode binding protein ( ZBP 1 ) , and the mouse c myc coding region determinant binding protein ( CRD BP ) that associates with beta actin and c myc mRNA , respectively . ^^^ |
|
| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| The mini array of TAAs comprised full length recombinant proteins expressed from cDNAs encoding c myc , p 53 , cyclin B 1 , p 62 , Koc , IMP 1 , and survivin . ^^^ |
|
| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| With enzyme immunoassay , we examined antibody frequencies to a panel of seven TAAs , c myc , cyclin B 1 , IMP 1 , Koc , p 53 , p 62 , and survivin , in 527 cancer patients ( 64 breast cancer patients , 45 colorectal cancers , 91 gastric cancers , 65 hepatocellular carcinomas , 56 lung cancers , and 206 prostate cancers ) , and 346 normals . ^^^ Antibody to cyclin B 1 was the initial discriminating node for gastric and lung cancers , and for hepatocellular carcinoma , and was a subsequent discriminating node in all of the other cancer cohorts . c myc was the initial discriminating node in breast cancer , p 62 in prostate cancer , and IMP 1 in colon cancer . ^^^ |
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| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| The c myc mRNA coding region determinant binding protein ( CRD BP ) was first identified as a masking protein that stabilizes c myc mRNA in a cell free mRNA degradation system . ^^^ |
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| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| A Coding Region instability Determinant Binding Protein ( CRD BP ) binds in vitro to c myc mRNA and appears to stabilize the mRNA . ^^^ The lack of CRD BP expression in normal colon did not result from indiscriminate protein or RNA degradation . c myc mRNA levels appeared to be elevated in tumor specimens . ^^^ |
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| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| These data suggest that c myc mRNA is rapidly degraded unless it is ( 1 ) translated without pausing or ( 2 ) protected by the CRD BP when pausing occurs . ^^^ |
|
| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| CRD BP : a c Myc mRNA stabilizing protein with an oncofetal pattern of expression . ^^^ CRD BP has been assigned a role in stabilizing c myc mRNA by preventing its endonucleolytic cleavage and in repressing the translation of the leader 3 IGF 2 mRNA , the major embryonic species of this message . ^^^ In breast carcinomas , CRD BP expression and or gene copy number gains in the region encompassing the c myc locus were detected in approximately 75 % of tumors , implying that the deregulated expression of c myc may be more widespread than previously believed . ^^^ |
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| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| The protein , which we call the c myc mRNA coding region instability determinant binding protein ( CRD BP ) , binds to c myc , insulin like growth factor 2 , and beta actin mRNAs , and to H 19 RNA . ^^^ |
|
| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| We analyzed binding of RNA targets by vigilin / DDP1 / SCP160p and by c myc coding region instability determinant ( CRD ) binding protein , CRD BP . ^^^ The CRD BP stabilizes c myc mRNA . ^^^ Competition between vigilin and CRD BP for binding to the CRD may therefore play a role in regulating c myc mRNA degradation . ^^^ |
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| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| We previously isolated and characterized a coding region determinant binding protein ( CRD BP ) that might regulate c myc mRNA post transcriptionally . ^^^ |
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| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| Our strategy was to identify ODNs that could interfere with the coding region determinant binding protein ( CRD BP ) , a protein that binds to the CRD region of the c myc mRNA . ^^^ |
|
| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| The coding region determinant binding protein ( CRD BP ) binds in vitro to c myc mRNA and is thought to stabilize the mRNA and increase c Myc protein abundance . ^^^ |
|
| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| The coding region determinant binding protein ( CRD BP ) was isolated by virtue of its high affinity to the c myc mRNA coding region stability determinant and shown to shield this message from nucleolytic attack , prolonging its half life . ^^^ |
|
| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| CRD BP mediates stabilization of betaTrCP 1 and c myc mRNA in response to beta catenin signalling . ^^^ CRD BP is essential for the induction of both betaTrCP 1 and c Myc by beta catenin signalling in colorectal cancer cells . ^^^ |
|
| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZI8 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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