| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.87713746 |
| To clarify the molecular mechanisms of MM 1 toward c Myc , cDNAs encoding MM 1 binding proteins were screened by the two hybrid method with MM 1 as a bait using a human HeLa cDNA library , and a cDNA encoding TIF 1 beta / KAP1 , a transcriptional corepressor , was obtained . 0.87713746^^^ |
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| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.53743301 |
| B Myc binds to MM 1 in a specific manner without becoming highly structured . 0.53743301^^^ |
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| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| The tumors studied lacked N myc overexpression , while showing up regulation of basic transcription factors , growth factors and receptors such as NSEP , c myc binding protein MM 1 , thymosin beta 10 ( TMSB 10 ) , TNF R superfamily member 10A ( TNFRSF10A ) and FZ 9 . ^^^ |
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| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| Interestingly , only three were affected in a similar fashion in both cell lines : c myc binding protein MM 1 , 23 kDa highly basic protein , and interferon inducible protein 9 27 ( IFITM 1 ) . ^^^ |
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| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| Myc 1 167 is partly helical , binds both to the target proteins Myc modulator 1 ( MM 1 ) and TATA box binding protein ( TBP ) , and displays the characteristics of a molten globule . ^^^ |
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| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| The isolation of the mouse MM 1 ; c Myc binding protein ( Myc Modulator 1 ) cDNA is described . ^^^ |
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| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expressions of p 53 ( clone D 07 ) , bcl 2 ( 100 D 5 ) , cathepsin D ( C 5 ) , c myc ( 9E11 ) , c erbB 2 ( CB 11 ) and Ki 67 ( MM 1 ) were determined by immunohistochemistry in paraffin embedded tissues from 32 multiple , T 1 , grade 2 3 bladder cancer patients ( 15 BCG responders , 17 nonresponders ) who had undergone a single course of BCG therapy ( Pasteur strain , 5 10 10 ( 8 ) CFU weekly for 6 weeks ) after complete removal of the tumors . ^^^ |
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| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| MM 1 , a novel c Myc associating protein that represses transcriptional activity of c Myc . ^^^ We have isolated the cDNA encoding a novel c Myc binding protein , MM 1 , by the yeast two hybrid screening of a human HeLa cell cDNA library . ^^^ As for the c Myc binding , glutathione S transferase MM 1 expressed in Escherichia coli bound in vitro to c Myc translated in reticulocyte lysate , and almost whole , the MM 1 molecule was necessary for the binding in the yeast two hybrid system . ^^^ The mammalian two hybrid assays in hamster CHO cells revealed that MM 1 interacts in vivo with the N terminal domain covering the myc box 2 , a transcription activating domain , of c Myc . ^^^ Furthermore , MM 1 repressed the activation of E box dependent transcription by c Myc . . ^^^ |
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| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| These translocations are considered to dysregulate genes which may be concerned with myelomagenesis ; i . e . , PRAD1 / cyclin D 1 , the c myc oncogene , FGFR 3 ( fibroblast growth factor receptor 3 ) , MMSET ( multiple myeloma SET domain ) , MUM 1 ( multiple myeloma oncogene 1 ) / IRF4 ( interferon regulatory factor 4 ) , and the c maf oncogene , respectively . ^^^ |
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| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| The remaining five cell lines have translocations involving other loci , including : 6p25 ( MUM 1 ) , 8q24 ( c myc ) , and 21q22 ( ? ^^^ |
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| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| MM 1 , a c Myc binding protein , is a candidate for a tumor suppressor in leukemia / lymphoma and tongue cancer . ^^^ We previously showed that MM 1 bound to myc box 2 within the transactivation domain of c Myc and repressed the E box dependent transcriptional activity of c Myc . ^^^ Although both the A157R and the wild type MM 1 bound to c Myc , only A157R lost the activities to repress both the E box dependent transcriptional activity of c Myc and the myc / ras cooperative transforming activity in rat 3Y1 cells . ^^^ The results suggest that MM 1 is a novel candidate for a tumor suppressor that controls the transcriptional activity of c Myc . . ^^^ |
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| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| Physical interaction of p 73 with c Myc and MM 1 , a c Myc binding protein , and modulation of the p 73 function . p 73 shares high sequence homology with the tumor suppressor p 53 . ^^^ We found MM 1 , a nuclear c Myc binding protein , was associated with p 73 alpha in both yeast two hybrid and in vitro pull down assays . ^^^ Expression of MM 1 strongly reduced the c Myc mediated inhibitory activity on p 73 alpha . ^^^ These results suggest that MM 1 may act as a molecular partner for p 73 to prevent the c Myc mediated inhibitory effect on its activity . . ^^^ |
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| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| Alterations in the expression and / or function of these transcription factors , or of the c Myc and Max interacting proteins , such as MM 1 and Mxi 1 , can influence the neoplastic process . ^^^ |
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| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| Repression of the c fms gene in fibroblast cells by c Myc MM 1 TIF1beta complex . ^^^ MM 1 has been reported to repress the E box dependent transcription activity of c Myc by recruiting histone deacetylase 1 complex via TIF1beta / KAP1 . ^^^ In this study , to identify target genes for c Myc MM 1 TIF1beta , we established rat 1 cells harboring the dominant negative form of TIF1beta to abrogate the pathway from TIF1beta to MM 1 c Myc . ^^^ |
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| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| Distinct localizations and repression activities of MM 1 isoforms toward c Myc . ^^^ MM 1 was identified as a c Myc binding protein and has been reported to repress the E box dependent transcription activity of c Myc by recruiting HDAC 1 complex via TIF 1 beta / KAP1 . ^^^ Furthermore , when repression activities of MM 1 isoforms toward c Myc transcription activity were examined by reporter gene assays in HeLa cells , MM 1alpha , MM 1gamma , and MM 1gamma , but not MM 1beta , were found to repress transcription activity of c Myc , and the degrees of repression by MM 1gamma and MM 1delta were smaller than those by MM 1 and MM 1alpha . ^^^ These results suggest that each MM 1 isoform distinctly regulates c Myc transcription activity in respective tissues . . ^^^ |
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| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99471 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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