| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :1.1964133 |
| Although the association of MYC with GCN 5 has been shown , its interaction with TIP 60 has never been analysed . 1.1964133^^^ Here , we show that MYC associates with TIP 60 and recruits it to chromatin in vivo with four other components of the TIP 60 complex : TRRAP , p 400 , TIP 48 and TIP 49 . 1.0940183^^^ |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| While Max lacks a transcription regulatory domain , the N terminus of Myc contains a transcription activation domain ( TAD ) that recruits cofactor complexes containing the histone acetyltransferases ( HATs ) GCN 5 and Tip 60 . ^^^ Moreover , the Myc : Max complex is differentially acetylated by p 300 and GCN 5 and is not acetylated by Tip 60 in vitro , suggesting distinct functions for these acetyltransferases . ^^^ |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| TIP 60 is a tightly regulated transcriptional coregulator , acting in a large multiprotein complex for a range of transcription factors including androgen receptor , Myc , STAT 3 , NF kappaB , E2F1 and p 53 . ^^^ |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| Furthermore , interleukin 9 induced c myc expression , which depends on STAT 3 activity , is abrogated by exogenous expression of Tip 60 . ^^^ |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| The c MYC oncoprotein is a substrate of the acetyltransferases hGCN5 / PCAF and TIP 60 . ^^^ The ability of c MYC to activate transcription relies in part on the recruitment of cofactor complexes containing the histone acetyltransferases mammalian GCN 5 ( mGCN 5 ) / PCAF and TIP 60 . ^^^ This study was initiated in order to determine whether c MYC is a direct substrate of mGCN 5 and TIP 60 . ^^^ We report here that mGCN5 / PCAF and TIP 60 acetylate c MYC in vivo . ^^^ Acetylation of c MYC by either mGCN5 / PCAF or TIP 60 results in a dramatic increase in protein stability . ^^^ |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| Enhancement of c Myc transforming activity by HTLV 1 p30II is dependent upon the transcriptional coactivators , transforming transcriptional activator protein / p434 and TIP 60 , and it requires TIP 60 histone acetyltransferase ( HAT ) activity and correlates with the stabilization of HTLV 1 p30II / Myc TIP 60 chromatin remodeling complexes . ^^^ |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| Induction of proliferating cell nuclear antigen ( PCNA ) , transforming growth factor beta ( TGFbeta ) , cyclo oxygenase 2 ( cox 2 ) , cpla 2 , osteocalcin ( OC ) , c myc , fibroblast growth factor 2 ( fgf 2 ) , bcl 2 , bax , and fgf 2 message as well as FGF 2 protein were significantly depressed in microg when compared to ground ( gr ) . ^^^ |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| Myc recruits histone acetyltransferases ( HATs ) to modify chromatin and is , itself , acetylated in mammalian cells by several of these HATs including p300 / CBP , GCN 5 , and Tip 60 . ^^^ |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92993 |
Pubmed |
SVM Score :0.0 |
| NA |
|