| Interacting proteins: Q92830 and P01106 |
Pubmed |
SVM Score :0.5499139 |
| Although the association of MYC with GCN 5 has been shown , its interaction with TIP 60 has never been analysed . 0.5499139^^^ |
|
| Interacting proteins: Q92830 and P01106 |
Pubmed |
SVM Score :0.0 |
| Myc widely influences chromatin in part through upregulation of the histone acetyltransferase GCN 5 . ^^^ |
|
| Interacting proteins: Q92830 and P01106 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that the recently described c Myc cofactor TRRAP recruits histone acetylase activity , which is catalyzed by the human GCN 5 protein . ^^^ |
|
| Interacting proteins: Q92830 and P01106 |
Pubmed |
SVM Score :0.0 |
| TRRAP and GCN 5 co expression stimulated E2F mediated transactivation , and c Myc repressed E2F transactivation dependent on an intact TRRAP / GCN5 binding motif . ^^^ |
|
| Interacting proteins: Q92830 and P01106 |
Pubmed |
SVM Score :0.0 |
| This complex contains the GCN 5 HAT , the c Myc interacting protein TRRAP / PAF400 , TAF ( 2 ) 30 , and other subunits . ^^^ |
|
| Interacting proteins: Q92830 and P01106 |
Pubmed |
SVM Score :0.0 |
| Recruitment of Gcn 5 containing complexes during c Myc dependent gene activation . ^^^ The yeast SAGA complex , which is orthologous to the human GCN 5 TRRAP complex that interacts with Myc in human cells , plays a role in Myc mediated chromatin opening at the promoter but may also be involved in later steps of gene activation . . ^^^ |
|
| Interacting proteins: Q92830 and P01106 |
Pubmed |
SVM Score :0.0 |
| Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN 5 acetylase activity for transcription activation . ^^^ Cell transformation by Myc involves its association with the transformation transactivation domain associated protein ( TRRAP ) and the human histone acetyltransferase ( HAT ) GCN 5 . ^^^ However , the identity of the HAT complexes recruited by Myc and the roles of TRRAP and GCN 5 in Myc function are still unclear . ^^^ Here we show that Myc co recruits TRRAP and GCN 5 via direct physical interactions of its N terminal activation / transformation domain with the human STAGA ( SPT 3 TAF GCN 5 acetylase ) coactivator complex . ^^^ We demonstrate that GCN 5 and TRRAP cooperate to enhance transcription activation by the N terminal activation domain of Myc in vivo and that this synergy requires both the SPT3 / GCN5 interaction domain of TRRAP and the HAT activity of GCN 5 . ^^^ |
|
| Interacting proteins: Q92830 and P01106 |
Pubmed |
SVM Score :0.0 |
| E1A represses c Myc and E2F 1 directed transcriptional activation in vivo by sequestering GCN 5 and / or TRRAP . ^^^ |
|
| Interacting proteins: Q92830 and P01106 |
Pubmed |
SVM Score :0.0 |
| The ability of c MYC to activate transcription relies in part on the recruitment of cofactor complexes containing the histone acetyltransferases mammalian GCN 5 ( mGCN 5 ) / PCAF and TIP 60 . ^^^ |
|
| Interacting proteins: Q92830 and P01106 |
Pubmed |
SVM Score :0.0 |
| RT PCR analyses revealed that the GCN 5 deficiency exhibited opposite influences on transcriptions of G1 / S phase transition related genes , i . e . repressions for E2F 1 , E2F 3 , E2F 4 , E2F 6 , DP 2 , cyclin A , cyclin D 3 , PCNA , cdc25B and p 107 ; and activations for p 27 , c myc , cyclin D 2 and cyclin G 1 . ^^^ |
|
| Interacting proteins: Q92830 and P01106 |
Pubmed |
SVM Score :0.0 |
| Myc recruits histone acetyltransferases ( HATs ) to modify chromatin and is , itself , acetylated in mammalian cells by several of these HATs including p300 / CBP , GCN 5 , and Tip 60 . ^^^ |
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| Interacting proteins: Q92830 and P01106 |
Pubmed |
SVM Score :0.0 |
| While Max lacks a transcription regulatory domain , the N terminus of Myc contains a transcription activation domain ( TAD ) that recruits cofactor complexes containing the histone acetyltransferases ( HATs ) GCN 5 and Tip 60 . ^^^ Moreover , the Myc : Max complex is differentially acetylated by p 300 and GCN 5 and is not acetylated by Tip 60 in vitro , suggesting distinct functions for these acetyltransferases . ^^^ |
|
| Interacting proteins: Q92830 and P01106 |
Pubmed |
SVM Score :0.0 |
| We have previously reported the identification and functional characterization of four different c Myc cofactors : TRRAP , hGCN 5 , TIP 49 , and TIP 48 . ^^^ |
|
| Interacting proteins: Q92830 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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