| Interacting proteins: P01106 and Q92793 |
Pubmed |
SVM Score :0.55435735 |
| Instead , CBP acetylates c MYC in vitro , and co expression of CBP with c MYC stimulates in vivo acetylation . 0.55435735^^^ |
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| Interacting proteins: P01106 and Q92793 |
Pubmed |
SVM Score :0.0 |
| The APC / beta catenin pathway is highly regulated and includes players such as GSK 3 beta , CBP , Groucho , Axin , Conductin , and TCF . c MYC and cyclin D 1 were recently identified as a key transcriptional targets of this pathway and additional targets are likely to emerge . ^^^ |
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| Interacting proteins: P01106 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Repression of c Myc and inhibition of G 1 exit in cells conditionally overexpressing p 300 that is not dependent on its histone acetyltransferase activity . p 300 and cAMP response element binding protein ( CREB ) binding protein ( CBP ) are two highly homologous , conserved transcriptional coactivators , and histone acetyltransferases ( HATs ) that link chromatin remodeling with transcription . ^^^ |
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| Interacting proteins: P01106 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Because p 300 does not substitute for all CREB binding protein ( CBP ) functions , we investigated whether CBP also negatively regulates c myc and prevents premature DNA synthesis . ^^^ Here , we show that antisense mediated depletion of CBP in serum deprived human cells leads to induction of c myc and that such cells emerge from quiescence without growth factors at a rate comparable with that of p 300 depleted cells . ^^^ The CBP depleted cells contained significantly reduced levels of the cyclin dependent kinase inhibitor p 21 and low levels of p 107 and p 130 ( but not pRb ) phosphorylation , suggesting that these factors , along with elevated levels of c Myc , contribute to induction of DNA synthesis . ^^^ Antisense c Myc reversed the phosphorylation of p 107 and p 130 and the induction of S phase in CBP depleted cells , indicating that up regulation of c myc is directly responsible for the induction of S phase . ^^^ When c myc expression was blocked by antisense c Myc , the apoptosis of the serum stimulated CBP depleted cells was reversed , indicating that high levels of c Myc contribute to apoptosis . ^^^ |
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| Interacting proteins: P01106 and Q92793 |
Pubmed |
SVM Score :0.0 |
| The coadaptor CREB binding protein ( CBP ) binds vIRF and synergizes transactivation of MYC , but , unexpectedly , closely related histone acetyltransferases p 300 and P / CAF potently suppress vIRF transactivation . ^^^ On the basis of the prediction that other interferon inhibiting viral transforming proteins behave similarly , we found that Epstein Barr virus induced nuclear antigen 2 ( EBNA 2 ) also binds p300 / CBP , and that both EBNA 2 and adenovirus E1A transactivate MYC through the PRF element . ^^^ For E1A , P / CAF coactivates MYC , whereas both p 300 and CBP suppress E1A transactivation . ^^^ For EBNA 2 , both P / CAF and CBP coactivate the MYC promoter , whereas p 300 suppresses EBNA 2 transactivation . ^^^ |
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| Interacting proteins: P01106 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Chromatin immunoprecipitation experiments show that STAT 3 and its cofactor NcoA / SRC1a are effectively recruited to the p 21 ( waf 1 ) promoter but that this is not followed by the association of the CREB binding protein ( CBP ) histone acetylase and the type 2 RNA polymerase as normally seen on the myc promoter . ^^^ Whereas the PI 3K / Akt pathway is constitutively activated in these cells , inactivation of this pathway restores the loading of CBP and the RNA polymerase and the expression of the p 21 ( waf 1 ) gene without having any effect on myc regulation . ^^^ |
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| Interacting proteins: P01106 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Reduction in Myc protein level results in defective recruitment of the CREB binding protein , Cdk 9 , and RNA polymerase complexes , indicating that Myc is necessary for STAT 3 transcription . ^^^ |
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| Interacting proteins: P01106 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Whereas p 300 and CBP can stabilize Myc independently of acetylation , p 300 mediated acetylation results in increased Myc turnover . ^^^ In addition , p 300 functions as a coactivator that is recruited by Myc to the promoter of the human telomerase reverse transcriptase gene , and p300 / CBP stimulates Myc TAD dependent transcription in a HAT domain dependent manner . ^^^ Our results suggest dual roles for p300 / CBP in Myc regulation : as a Myc coactivator that stabilizes Myc and as an inducer of Myc instability via direct Myc acetylation . . ^^^ |
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| Interacting proteins: P01106 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01106 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
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