| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Cells were constrained into varying degrees of roundness by plating onto culture surfaces coated with different concentrations of poly ( 2 hydroxyethyl methacrylate ) ( poly [ HEMA ] ) and assayed for proliferation capacity and levels of c myc , c ras , c fos , and c fes mRNAs . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Also , total protein synthesis and the amounts of poly ( A ) + , c fos , c myc , and heat shock protein HSP 68 mRNAs were increased . ^^^ By contrast with what we have observed in the beating heart , the augmentation of the coronary pressure in the arrested heart stimulates total protein synthesis and increases the amount of poly ( A ) + , c fos , c myc , and HSP 68 mRNAs but has no effect on the expression of both MHC iso mRNAs . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Shortening of the poly ( A ) tail of the c myc message appears to precede degradation of the transcript . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| The amplified catalase and c myc genes in HP 100 1 cells were not decreased by treatment of the cells with inhibitors of poly ( ADP Ribose ) polymerase , such as nicotinamide and benzamide . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| However , the size and number of expressed myc poly ( A+ ) RNA in the normal cells and cancer cell lines differed . ^^^ Although the normal cells and HBPC 1 expressed a single myc transcript , 1 . 7 kilobase ( kb ) and 2 . 3 kb , respectively , both HBPC 2 and HBPC 3 expressed two myc poly ( A+ ) RNAs , 1 . 7 kb and 2 . 3 kb . . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Various poly ( ADP ribose ) polymerase inhibitors also eliminated human Ha ras in the NIH 3T3 transformant and the c myc gene in HL 60 cells . . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| We demonstrate by label transfer and gel shift experiments that a 32 kDa polypeptide , present in nuclear extracts , specifically interacts with the AU rich domains present within the 3 ' untranslated region of human granulocyte macrophage colony stimulating factor , c fos , and c myc mRNAs and a similar domain downstream of the poly ( A ) addition site of the adenovirus IVa 2 mRNA . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| A binding assay between isolated NM and 32P end labeled c myc fragments in the presence of unlabeled competitors was used , and a 3 ' end DraI / DraI fragment of 172 base pairs containing the first of the two polyadenylation [ poly ( A ) ] signals was identified as an in vitro MAR . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| The nucleotide sequence at the breakpoint shows that the rearranged allele of MYC is truncated 24 nucleotides before the first poly ( A ) addition signal . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Maximal c myc messenger RNA ( mRNA ) accumulation , as determined by densitometric analysis of Northern blots of poly ( A ) + uterine RNA was observed 3 h after E 2 treatment . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| We compared the effect of tert butyl hydroperoxide ( Bu OOH ) on DNA strand breakage , poly ADP ribosylation of chromosomal proteins and the expression of the proto oncogenes c fos and c myc between non promotable clone 30 and promotable clone 41 of mouse epidermal cells JB 6 . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Poly ( A ) tail shortening is the translation dependent step in c myc mRNA degradation . ^^^ Our results indicate that the stabilization of c myc mRNA in the absence of translation can be fully explained by the inhibition of translation dependent poly ( A ) tail shortening . ^^^ First , the normally rapid shortening of the c myc poly ( A ) tail was slowed down by a translation block . ^^^ Second , c myc messengers which carry a short poly ( A ) tail , as a result of prolonged actinomycin D or 3 ' deoxyadenosine treatment , were not stabilized by the inhibition of translation . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| To lower their concentration and stabilize the antisense effect against c myc , oligonucleotides were covalently linked to poly ( L lysine ) and administered in ternary complexes formed with heparin ( 100 micrograms / ml ) . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we have shown that the poly ( A ) tail of c myc mRNA is lost during degradation of the messenger , as was described previously for c myc mRNA in an in vitro system . ^^^ The time required for the loss of the poly ( A ) tail is similar to the half life of c myc mRNA . . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| FI subclonal lines formed tumors in syngeneic mice and contained no detectable poly A messenger RNA for GM CSF or IL 3 , and no elevation in c myc , c abl , c src , or erb B onc gene specific messenger RNA compared to parent factor dependent lines . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Moreover , histone proteins did not induce increased degradation of gamma globin mRNA , c myc mRNA , or total poly ( A ) or poly ( A ) + polysomal mRNAs . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Relatively stable population of c myc RNA that lacks long poly ( A ) . ^^^ S 1 nuclease transcript mapping and promoter specific probes were utilized to show that both the stable 2 . 2 kb and the labile 2 . 4 kb c myc RNA populations have 5 ' ends at the second promoter site ( P 2 ) and 3 ' ends at the second poly ( A ) addition site . ^^^ Preliminary estimates of their half lives ( t1 / 2 ) showed that the poly ( A ) + c myc RNA had a t1 / 2 of 12 min , while the c myc RNA that did not bind to oligo ( dT ) cellulose had a t1 / 2 of greater than 1 h . ^^^ Several other cell types contain both poly ( A ) + and nonpoly ( A ) + c myc RNAs including HeLa cells , normal human bone marrow cells , and normal mouse fetal liver cells . ^^^ In agreement with the results in HL 60 cell , HeLa cell poly ( A ) + c myc RNA was more labile than c myc RNA that lacked poly ( A ) . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Northern blot analysis of poly ( A+ ) RNA indicated a greater than 85 % decrease in c myc transcripts following a brief exposure to the inducing agents , dimethyl sulfoxide or hypoxanthine . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| It has been shown previously that interferons ( IFNs ) alpha and beta cause a reduction in the steady state level of poly ( A ) c myc RNA in the Burkitt lymphoma , Daudi . ^^^ In this report we show that the c myc RNA reduction is not mediated by simple changes in the poly adenylation of either nascent or existing c myc transcripts , since similar reductions of c myc sequences were observed in poly ( A ) and total cellular RNA preparations from IFN beta treated cells . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Loss of the MYC gene amplified in human HL 60 cells after treatment with inhibitors of poly ( ADP ribose ) polymerase or with dimethyl sulfoxide . ^^^ On differentiation of the HL 60 cells into granulocytes induced by several inhibitors of poly ( ADP ribose ) polymerase [ NAD+ poly ( adenosine diphosphate D ribose ) ADP D ribosyltransferase , EC 2 . 4 . 2 . 30 ] including benzamide , nicotinamide , coumarin , and 4 hydroxyquinazoline or dimethyl sulfoxide , some MYC loss was observed . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Using a synthetic oligonucleotide complementary to the human c myc mRNA as the probe , we detected a more than 75 % reduction in the c myc hybridizable poly ( A ) + RNA in the IFN beta treated cells . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the ability to respond directly to cotransfected ICP 27 can be transferred to chloramphenicol acetyltransferase reporter genes by replacement of their SV 40 derived splicing and poly ( A ) signals with the 3 ' AU rich and poly ( A ) RNA processing signals from the normally highly labile beta interferon and c myc mRNA species . ^^^ ICP 27 expressed in bacteria bound specifically to in vitro generated RNA from both the beta interferon and c myc intronless AU rich 3 ' RNA processing regions , but not to the SV 40 derived early region splice signal and poly ( A ) sequences . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Since aclarubicin partially inhibited total and poly ( A ) ( + ) RNA synthesis , this macromolecular synthesis inhibition may be causally related to the decrease in c myc and c myb mRNA levels . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Poly ( A ) shortening and degradation of the 3 ' A+U rich sequences of human c myc mRNA in a cell free system . ^^^ To account for rapid deadenylation , we suggest that the c myc poly ( A ) poly ( A ) binding protein complex is readily dissociated , generating a protein depleted poly ( A ) tract that is no longer resistant to nucleases . . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Quantitative dot blot and RNA blot hybridization experiments in which whole kidney poly ( A ) + RNA was hybridized with a c myc RNA probe showed a 2 to 6 fold increase in c myc mRNA at 2 weeks , and a 25 to 30 fold increase in c myc mRNA at 3 weeks of age in polycystic mice , as compared to normal littermates . c myc expression was also examined under two conditions in which kidney cell growth was experimentally induced in normal adult mice : compensatory renal hypertrophy and tubule regeneration following folic acid induced renal cell injury . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| The DNA binding activities were partially fractionated by high performance liquid chromatography gel filtration and include an erythrocyte specific protein which binds to a c myc gene poly ( dG ) homopolymer sequence similar to that found upstream of the chicken beta A globin gene . . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Agarose gel electrophoresis of poly ( A ) RNA extracts of adenoma tissues followed by hybridization with 5 myc DNA yielded two distinct c myc mRNA species [ 2 . 1 and 4 . 0 kilobases ( kb ) ] . ^^^ Thyroid cancer tissue poly ( A ) RNA revealed a predominant larger c myc mRNA species ( approximately 6 kb ) and a smaller 2 . 1 kb species . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Viral infection , but not poly rI . rC treatment , enhanced the expression of the pMIF3 / 10 gene , as well as two other cellular genes ; H 2 and c myc , however , the expression of beta actin gene was unaltered . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| RNA gel blotting analysis of poly ( A ) selected RNA of a thymoma and its lymph node metastasis showed identical pattern of c myc transcripts . . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Translation of transcripts bearing the human c myc 5 ' UTR was markedly stimulated by the presence of 3 ' poly ( A ) . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Following deadenylation , nucleolytic decay of the 3 ' UTR occurs generating 3 ' decay intermediates via a ribonucleolytic activity that can assemble on the c myc 3 ' UTR in a poly ( A ) independent manner . . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| This treatment is associated with increased expression of c myc , c fos , jun family members , and transforming growth factor beta 1 mRNA and with partial proteolytic cleavage of poly ( ADP ribose ) polymerase and lamin B . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Whereas the benzamide derivatives are inhibitors of poly ( ADP ribose ) polymerase the acid analogues are not , suggesting that inhibition of this enzyme is not the basis for superinduction of the c myc gene . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| We describe a novel 75 Kd sequence specific cytoplasmic factor ( p 75 ) that binds selectively to a 83 nucleotide 3 ' untranslated region of R 2 mRNA and did not bind to the 5 ' UTR , the coding region of the R 2 message or to the 3 ' UTRs of other mRNAs ( from c myc , GM CSF and the iron responsive element from the transferrin receptor mRNA ) , or to the homopolymer poly ( A ) sequence . p 75 RNA binding activity , which requires new protein synthesis , is not present in untreated cells , but is induced following TGF beta 1 stimulation . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Murine erythroleukemia ( MEL ) cells exposed to DMSO were assessed for their ability to methylate poly ( A ) + RNA and accumulate RNA transcripts of globin and nonglobin genes ( c myc , beta actin and MER 5 ) . ^^^ Moreover , we observed that treatment of MEL cells with selective inhibitors of RNA methylation caused fragmentation of beta major globin and c myc mRNAs , two RNA transcripts coded by developmentally regulated genes , while had no detectable effect on the structural integrity of poly ( A ) + RNA transcripts transcribed by two housekeeping genes ( beta actin and MER 5 ) . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| However , the involvement of c Myc , c Jun , poly ADPR polymerase and antioxidant enzymes CuZn SOD and catalase was observed . . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Our findings demonstrate the involvement of c Myc , c Jun , antioxidant enzymes CuZn superoxide dismutase and catalase , and perhaps poly ADP ribosylation in ADM induced cell death . . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Steady state levels of c fos , c jun , jun B , and c myc transcripts and proteins were documented by Northern blots of poly ( A ) enriched RNA derived from resected livers and Western blots of total nuclear protein , respectively . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| The c myc oncogene and poly ( ADP ribose ) polymerase ( PARP ) , which also have a dual function in proliferation and apoptosis , showed an early induction by both CdA and PHA . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| But , our studies revealed that the c Myc induced apoptosis is associated with a specific cleavage of poly ( ADPribose ) polymerase ( PARP ) , suggesting that a cysteine protease of the ICE / CED 3 family is involved . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Members of the poly ( rC ) binding protein family stimulate the activity of the c myc internal ribosome entry segment in vitro and in vivo . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Enhancement of IRES mediated translation of the c myc and BiP mRNAs by the poly ( A ) tail is independent of intact eIF4G and PABP . ^^^ |
|
| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Study of the distribution of the poly ( A ) tail length of c myc mRNA in several cell lines revealed a distinct , prevailing population with short poly ( A ) tails , derived through sequential deadenylation . ^^^ Our data indicate that under these conditions , a long poly ( A ) tail is not instrumental for c myc mRNA translation and furthermore , the discrepancy in the steady state of c myc mRNA level : c MYC protein ratio between control cells and cells treated with cordycepin indicates that c myc mRNA is subjected to translational control . . ^^^ |
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| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| The steady state levels of mRNA for the poly ( ADP ribose ) polymerase ( PARP ) , c myc , p 53 , and histone H 3 genes were investigated in 31 high grade B cell lymphomas by northern blot analysis . ^^^ |
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| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| The expression of myc , fos , and Ha ras was evaluated by Northern blot analysis of liver derived poly ( A ) + mRNA from these same animals . ^^^ |
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| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| To demonstrate the utility of the assay , an RNA probe was constructed containing a fragment of the c myc 3 ' untranslated region and an 85 base poly ( A ) tail . ^^^ |
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| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Although in dividing cells c myc mRNA decays via a sequential pathway involving removal of the poly ( A ) tract followed by degradation of the mRNA body , TPA activates a deadenylation independent pathway . ^^^ |
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| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Analysis of Rat 1 c myc null cells shows these same death stimuli induce apoptosis with characteristic features of nuclear condensation , membrane blebbing , poly ( ADP ribose ) polymerase cleavage , and DNA fragmentation ; however , this Myc independent apoptosis is not inhibited by Bcl 2 . ^^^ |
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| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Subgroups of 4 5 mice were sacrificed at 3 , 6 and 24 h after therapy so that tumors could be examined for poly ( ADP ribose ) polymerase ( PARP ) and DNA ladder evidence for apoptosis and for BCL 2 , p 53 , p 21 , GADD 45 , TGF beta 1 and c MYC gene and protein expression . ^^^ |
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| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| Accordingly , G3BP is tightly associated with a subset of poly ( A ) ( + ) mRNAs containing its high affinity binding sequence , such as the c myc mRNA in mouse embryonic fibroblasts . ^^^ |
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| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| The expression levels of heat shock protein 70 ( HSP 70 ) , c jun and c fos genes were remarkably up regulated and those of c myc and poly ( ADP ribose ) polymerase ( PARP ) were down regulated in bupivacaine treated cells . ^^^ |
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| Interacting proteins: Q53GL7 and P01106 |
Pubmed |
SVM Score :0.0 |
| PARP 10 , a novel Myc interacting protein with poly ( ADP ribose ) polymerase activity , inhibits transformation . ^^^ Functionally , PARP 10 inhibits c Myc and E1A mediated cotransformation of rat embryo fibroblasts , a function that is independent of PARP activity but that depends on a functional NES . ^^^ PARP 10 , a novel Myc interacting protein with poly ( ADP ribose ) polymerase activity , inhibits transformation . ^^^ Here , we describe the isolation of a novel 150 kDa protein , designated PARP 10 , that interacts with Myc . ^^^ Molecular modeling and biochemical analysis define a PARP domain that is capable of ADP ribosylating PARP 10 itself and core histones , but neither Myc nor Max . ^^^ |
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