| Interacting proteins: Q13309 and P01106 |
Pubmed |
SVM Score :0.53893223 |
| We and others recently showed that the F box protein Skp 2 interacts with c Myc and participates in its ubiquitylation and proteasomal degradation . 0.53893223^^^ |
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| Interacting proteins: Q13309 and P01106 |
Pubmed |
SVM Score :0.59219028 |
| We have found that Skp 2 interacts with c Myc and participates in its ubiquitylation and degradation . 0.59219028^^^ |
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| Interacting proteins: Q13309 and P01106 |
Pubmed |
SVM Score :0.0 |
| The 10 protein of hepatitis B virus binds to the F box protein Skp 2 and inhibits the ubiquitination and proteasomal degradation of c Myc . ^^^ |
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| Interacting proteins: Q13309 and P01106 |
Pubmed |
SVM Score :0.0 |
| Here , we provide several lines of evidence that c Myc promotes ubiquitin dependent proteolysis by directly activating expression of the Cul 1 gene , encoding a critical component of the ubiquitin ligase SCF ( SKP 2 ) . ^^^ |
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| Interacting proteins: Q13309 and P01106 |
Pubmed |
SVM Score :0.0 |
| Overexpression of c myc restored the expression of Skp 2 and Cul 1 mRNA , reduced the amounts of p 21 ( WAF 1 ) and p 27 ( Kip 1 ) proteins , and canceled GATA 2 induced growth suppression , suggesting that down regulation of c myc expression may be primarily responsible for GATA 2 induced growth suppression . ^^^ GATA 2 / ER suppressed cytokine dependent growth of MNCs and Sca 1 ( + ) Lin ( ) cells by about 70 % , which was also accompanied by the reduced expression of c myc , Skp 2 , and Cul 1 mRNA and the accumulation of p 21 ( WAF 1 ) and p 27 ( Kip 1 ) proteins . ^^^ |
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| Interacting proteins: Q13309 and P01106 |
Pubmed |
SVM Score :0.0 |
| Skp 2 regulates Myc protein stability and activity . ^^^ Here , we report that the oncoprotein and Ub ligase Skp 2 regulates Myc ubiquitylation and stability . ^^^ Because of the growing number of Ub ligases that function as transcriptional coactivators , we speculated that Skp 2 might also regulate Myc ' s transcriptional activity . ^^^ Consistent with this model , we also show that Skp 2 is a transcriptional coactivator for Myc , recognizing an essential element within the Myc activation domain and activating Myc target genes . ^^^ These data suggest that Skp 2 functions to connect Myc activity and destruction , and reveal an unexpected oncoprotein connection that may play an important role in controlling cell growth in normal and cancer cells . . ^^^ |
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| Interacting proteins: Q13309 and P01106 |
Pubmed |
SVM Score :0.0 |
| New work , published in the May issue of Molecular Cell , reveals that ubiquitination of Myc by the oncogenic SCF ( Skp 2 ) complex not only promotes Myc turnover but is also required for Myc transcriptional activation , suggesting that Myc activity is `` licensed ' ' by ubiquitination . . ^^^ |
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| Interacting proteins: Q13309 and P01106 |
Pubmed |
SVM Score :0.0 |
| Increase of Skp 2 , which is involved in the degradation of cell cycle regulators including p27Kip1 , p 21 and c myc , is one of the important mechanisms for dysregulation of cell cycles in various cancers . ^^^ |
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| Interacting proteins: Q13309 and P01106 |
Pubmed |
SVM Score :0.0 |
| Altered expression of Skp 2 , c Myc and p 27 proteins but not mRNA after H . pylori eradication in chronic gastritis . ^^^ Cell cycle progression is dependent on the proteasomal degradation of p 27 , a cyclin dependent kinase inhibitor and gastric tumor suppressor , following ubiquitination mediated by Skp 2 . c Myc is a transcriptional repressor of p 27 and also a target of Skp 2 . ^^^ The effect of eradicating H . pylori on gastric epithelial p 27 , Skp 2 , and c Myc proteins and mRNA was investigated in 22 patients with chronic gastritis , by immunohistochemistry and laser capture microdissection . ^^^ The percentage of gastric antral epithelial cells expressing p 27 protein was significantly higher after eradication of H . pylori ( mean+ / s . e . m . 37+ / 2 . 4 % pre eradication vs 55+ / 2 . 8 % post eradication ; P < 0 . 001 ) , while Skp 2 and c Myc protein expressing cells were lower ( Skp 2 : 35+ / 3 . 8 vs 23+ / 2 . 6 % , P=0 . 009 ; c Myc : 47+ / 3 . 6 vs 30+ / 3 . 8 % , P < 0 . 001 ) . mRNA expressions of p 27 , Skp 2 , and c Myc ( normalized for 18SrRNA ) were not changed by H . pylori eradication . ^^^ H . pylori increases c Myc and decreases gastric epithelial p 27 protein expression in association with increased expression of Skp 2 , the regulator of p 27 ' s ubiquitin ligase complex . ^^^ |
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| Interacting proteins: Q13309 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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