| Interacting proteins: Q13287 and P01106 |
Pubmed |
SVM Score :0.73590571 |
| Nmi interacts with c Myc , N Myc , Max , and fos , as demonstrated by yeast two hybrid and coimmunoprecipitation assays . 0.73590571^^^ |
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| Interacting proteins: Q13287 and P01106 |
Pubmed |
SVM Score :0.0 |
| Here , using a yeast genetic screen , we identified a novel gene , Nmi , that binds to N myc and C myc . ^^^ Co precipitation studies of Nmi with N myc and C myc confirmed the interaction in mammalian cells . ^^^ Among several cancer cell lines , high expression of Nmi was found in myeloid leukemias , which also express high levels of C myc . ^^^ Isolation and characterization of Nmi , a novel partner of Myc proteins . ^^^ |
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| Interacting proteins: Q13287 and P01106 |
Pubmed |
SVM Score :0.0 |
| Nmi was initially identified through a yeast two hybrid interaction with N Myc but it also interacts with c Myc , Max , Fos , and several other transcription factors , including signal transducer and activator of transcription ( Stat ) proteins . ^^^ |
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| Interacting proteins: Q13287 and P01106 |
Pubmed |
SVM Score :0.0 |
| Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN . ^^^ A number of interaction partners of Myc have been identified , such as Max , p 107 , TBP , YY 1 , Miz 1 , AP 2 and Nmi . ^^^ In contrast to the well defined binding of Max to Myc family proteins the interaction of Nmi with Myc or MycN is only poorly characterized . ^^^ By employing the yeast two hybrid system we have mapped the regions of MycN and Myc responsible for binding to Nmi . ^^^ In contrast , for Myc a C terminal portion of the protein , and possibly also a central part , is involved in Nmi interaction . ^^^ |
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| Interacting proteins: Q13287 and P01106 |
Pubmed |
SVM Score :0.0 |
| A novel tricomplex of BRCA 1 , Nmi , and c Myc inhibits c Myc induced human telomerase reverse transcriptase gene ( hTERT ) promoter activity in breast cancer . ^^^ Nmi functioned as an adaptor molecule to recruit c Myc to a complex containing Nmi . c Myc . ^^^ Because c Myc can activate transcription of the human telomerase reverse transcriptase gene ( hTERT ) , we addressed the role of BRCA 1 and Nmi in modulating c Myc induced hTERT promoter activity . ^^^ Although Nmi or BRCA 1 alone had no effect on c Myc induced hTERT promoter activity , BRCA 1 together with Nmi significantly inhibited this c Myc induced hTERT promoter activity ( approximately 75 % inhibition ) . ^^^ Two mutated forms of BRCA 1 , a missense ( A1708E ) and a nonsense ( Y1853X ) that have been identified in familial breast cancers , associated with Nmi and c Myc but failed to suppress c Myc induced hTERT promoter activity . ^^^ |
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| Interacting proteins: Q13287 and P01106 |
Pubmed |
SVM Score :0.0 |
| A small fraction of genes were highly sensitive to histone hyper acetylation , including XRCC 1 , HOXB 6 , CDK 10 , MYC , MYB , NMI and CBFA2T3 and many were trans acting factors relevant to cancer . ^^^ |
|
| Interacting proteins: Q13287 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13287 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13287 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13287 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13287 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13287 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13287 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|