| Interacting proteins: Q06830 and P01106 |
Pubmed |
SVM Score :0.0 |
| Pag , a putative tumor suppressor , interacts with the Myc Box 2 domain of c Myc and selectively alters its biological function and target gene expression . ^^^ We now show that Pag promotes increased cell size and confers a proapoptotic phenotype , two hallmark features of ectopic c Myc overexpression . ^^^ Pag and c Myc also confer resistance to oxidative stress , a previously unrecognized property of the latter protein . ^^^ In contrast , Pag inhibits tumorigenesis by c Myc overexpressing fibroblasts and causes a broad but selective loss of c Myc target gene regulation . ^^^ Pag is therefore an MBII interacting protein that can either mimic or enhance some of the c Myc properties while at the same inhibiting others . ^^^ |
|
| Interacting proteins: Q06830 and P01106 |
Pubmed |
SVM Score :0.0 |
| Overexpression of alpha fetoprotein , c myc , cyclin D 1 , proliferation associated protein PAG , and cytokeratin 18 were more dramatic in arsenic induced HCC than spontaneous tumors . ^^^ |
|
| Interacting proteins: Q06830 and P01106 |
Pubmed |
SVM Score :0.0 |
| The review then discusses recent observations showing that loss of the TS protein peroxiredoxin 1 ( prdx 1 ) and increased expression of the c onc protein c Myc , each leads to increased oxidative DNA damage . ^^^ |
|
| Interacting proteins: Q06830 and P01106 |
Pubmed |
SVM Score :0.0 |
| Regulation of reactive oxygen species , DNA damage , and c Myc function by peroxiredoxin 1 . ^^^ We previously demonstrated that peroxiredoxin 1 ( Prdx 1 ) , a scavenger of reactive oxygen species ( ROS ) , interacts with a region of the c Myc transcriptional regulatory domain that is essential for transformation . ^^^ Most notably , c Myc mediated transformation is inhibited , implying a tumor suppressor role for Prdx 1 . ^^^ |
|
| Interacting proteins: Q06830 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|