| Interacting proteins: P01106 and Q04206 |
Pubmed |
SVM Score :0.0 |
| We show that selective inhibition of RelA NF kappaB decreased induction of NFKB 1 , interleukin 2 , and interleukin 2Ralpha genes but not c myc . ^^^ |
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| Interacting proteins: P01106 and Q04206 |
Pubmed |
SVM Score :0.0 |
| The RelA NF kappaB subunit and the aryl hydrocarbon receptor ( AhR ) cooperate to transactivate the c myc promoter in mammary cells . ^^^ Here we demonstrate a physical and functional association between the RelA subunit of NF kappaB and AhR resulting in the activation of c myc gene transcription in breast cancer cells . ^^^ In transient co transfection , RelA and AhR gene products demonstrated cooperation in transactivation of the c myc promoter , which was dependent on the NF kappaB elements , and in induction of endogenous c Myc protein levels . ^^^ Thus , the RelA and AhR proteins functionally cooperate to bind to NF kappaB elements and induce c myc gene expression . ^^^ |
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| Interacting proteins: P01106 and Q04206 |
Pubmed |
SVM Score :0.0 |
| A novel form of the RelA nuclear factor kappaB subunit is induced by and forms a complex with the proto oncogene c Myc . ^^^ We have discovered that both c Myc and 5 Myc can induce a previously undescribed , truncated form of the RelA ( p 65 ) NF kappaB subunit , RelA ( p 37 ) . ^^^ This result is explained , however , by the observation that RelA ( p 37 ) , but not RelA ( p 65 ) , forms a high molecular mass complex with c Myc . ^^^ These results demonstrate a previously unknown functional and physical interaction between RelA and c Myc with many significant implications for our understanding of the role that both proteins play in the molecular events underlying tumourigenesis . . ^^^ |
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| Interacting proteins: P01106 and Q04206 |
Pubmed |
SVM Score :0.0 |
| PPARgamma agonists activated NF kappaB ( p 50 , Rel A , c Rel ) binding to the upstream kappaB regulatory element site of c myc . ^^^ |
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| Interacting proteins: P01106 and Q04206 |
Pubmed |
SVM Score :0.0 |
| Here , we show that c myc dependent growth during T cell activation requires c Rel and RelA and that blocking this growth by inhibiting protein kinase C theta ( PKCtheta ) coincides with a failure to upregulate c myc due to impaired RelA nuclear import and inhibition of NFAT dependent c rel transcription . ^^^ These results demonstrate that different Rel / NF kappaB dimers regulate the mitogenic growth of mature T and B cells , with a signaling pathway incorporating PKCtheta and NFAT controlling c Rel / RelA induced c myc expression in activated T cells . . ^^^ |
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| Interacting proteins: P01106 and Q04206 |
Pubmed |
SVM Score :0.0 |
| Based on the skin phenotype observed with misregulation of transcription factors such as p 63 , c Myc , RelA , pRb , Klf 4 and others , their function in controlling proliferation and differentiation is dissected . ^^^ |
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| Interacting proteins: P01106 and Q04206 |
Pubmed |
SVM Score :0.0 |
| Compared with control cells , rel 3983D displayed increased NF kappaB binding and higher levels of the NF kappaB transactivating subunits c Rel , RelA , and RelB , which seemed functional as judged by induction of c Myc and vimentin , products of two NF kappaB target genes . ^^^ |
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| Interacting proteins: P01106 and Q04206 |
Pubmed |
SVM Score :0.0 |
| Finally , construction of a gene expression network of the differentially expressed genes revealed that 69 genes centred around five well known genes : TP 53 , RELA , MYC , epidermal growth factor receptor and beta catenin . ^^^ |
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| Interacting proteins: P01106 and Q04206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q04206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q04206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and Q04206 |
Pubmed |
SVM Score :0.0 |
| NA |
|