| Interacting proteins: Q02447 and P01106 |
Pubmed |
SVM Score :0.0 |
| Their gene products encode proteins involved in the regulation of cell growth ( proto oncogenes c myc and c fos ) , a gene inducible by growth arrest and DNA damage ( GADD 153 ) , the cytokine interleukin ( IL ) 1 alpha and beta and finally a differentiation associated small proline rich gene ( SPR 2 ) . ^^^ |
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| Interacting proteins: Q02447 and P01106 |
Pubmed |
SVM Score :0.0 |
| Specific mRNA was detected using cDNA probes encoding the proto oncogenes c fos and c myc and the growth arrest and DNA damage ( GADD 153 ) gene , all recently shown by our laboratory to be modulated by UV in newborn keratinocytes ; interleukin ( IL ) 1a , IL 1b , and the IL 1 receptor antagonist ( IL 1ra ) , two keratinocyte cytokines and their competitive inhibitor , implicated in the immunomodulatory effect of UV ; and SPR 2 , a recently cloned gene known to be induced during normal keratinocyte differentiation and by lethal UV C irradiation . ^^^ |
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| Interacting proteins: Q02447 and P01106 |
Pubmed |
SVM Score :0.0 |
| Cotransfection experiments , in mammalian and insect cells , indicated that Sp 1 trans activate c myc promoter , whereas Sp 3 did not . ^^^ In addition , enforced expression of Sp 3 repressed Sp 1 mediated activation of c myc . ^^^ |
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| Interacting proteins: Q02447 and P01106 |
Pubmed |
SVM Score :0.0 |
| Transfection experiments in Drosophila cells that lack endogenous Sp activity demonstrated that Sp 3 does not possess an active repression domain that can function in insect cells , rather it is a weak transcriptional activator of the c myc promoter . ^^^ |
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| Interacting proteins: Q02447 and P01106 |
Pubmed |
SVM Score :0.0 |
| This analysis indicated that Sp 1 , Sp 3 and c Myc bind to the GC boxes and E boxes , respectively , within the promoter and help activate the transcription of mTert gene . ^^^ |
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| Interacting proteins: Q02447 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q02447 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02447 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02447 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|