| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.57644577 |
| In response to TGF beta , Smad 3 binds to c Myc ; knocking down c Myc , Smad 3 does not bind to the TERT gene , suggesting that c Myc recruits Smad 3 to the TERT promoter . 0.57644577^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| Mad 3 and Mad 4 : novel Max interacting transcriptional repressors that suppress c myc dependent transformation and are expressed during neural and epidermal differentiation . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| Mad 3 and Mad 4 : novel Max interacting transcriptional repressors that suppress c myc dependent transformation and are expressed during neural and epidermal differentiation . ^^^ Using a rat embryo fibroblast transformation assay , we show that both Mad 3 and Mad 4 inhibit c Myc dependent cell transformation . ^^^ An examination of the expression patterns of all mad genes during murine embryogenesis reveals that mad 1 , mad 3 and mad 4 are expressed primarily in growth arrested differentiating cells . mxi 1 is also expressed in differentiating cells , but is co expressed with either c myc , N myc , or both in proliferating cells of the developing central nervous system and the epidermis . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| Four additional bHLH ZIP proteins , Mad 1 , Mxi 1 , Mad 3 and Mad 4 , heterodimerize with Max and also repress transcription of c myc responsive genes . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| In in vitro protein : protein association assays , dMax interacted with c Myc , N Myc , L Myc , Mad 1 , Mxi 1 , Mad 3 and Mad 4 , but not with itself or wild type Max . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| In contrast , mad 3 expression was associated with progression through S phase and the proliferative burst of differentiating preadipocytes , overlapping in part c myc expression . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| Smad 3 and E2F 4 directly bound to the element ( TIE / E2F ) , and substitution of two nucleotides in TIE / E2F impaired binding of both Smad 3 and E2F 4 as well as serum induced activation and TGF beta induced suppression of the c myc promoter activity . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| Direct interaction of c Myc with Smad 2 and Smad 3 to inhibit TGF beta mediated induction of the CDK inhibitor p 15 ( Ink4B ) . ^^^ In this study , we reveal that c Myc physically interacts with Smad 2 and Smad 3 , two specific signal transducers involved in TGF beta signaling . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| Recent work shows that c Myc repression by TGFbeta is mediated by the nuclear translocation of a novel , preformed complex composed of Smad 3 , E2F4 or E2F5 , and the Rb related factor p107 . . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| We defined how , in the same context , Smad 3 can also mediate transcriptional repression of the growth promoting gene c myc . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| The TGF beta 1 target genes c myc and p 15 ( ink4b ) were deregulated in the absence of Smad 3 . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| Mad proteins ( Mad 1 , Mxi 1 , Mad 3 , Mad 4 , Mnt / Rox ) are biochemical and biological antagonists of c Myc oncoprotein . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| RESULTS : c Myc protein was expressed in Smad 3 MSC and Smad3DeltaC MSC . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| Cotransfection with a Smad 3 expressing plasmid further repressed rTERT transcription and c myc expression , while cotransfection with the corresponding antisense Smad 3 construct had the opposite effect . ^^^ Thus TGFbeta inhibition of rTERT gene expression was directly mediated by Smad 3 via the Smad binding element , while c myc appears to primarily regulate its constitutive or induced expression . . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| Here we summarize the findings obtained from the myc / max / mad knockout mice generated to date , namely those in which the N myc , c myc , L myc , mad 1 , mxi 1 , mad 3 , mnt , or max genes have been targeted . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| The MAX protein is at the center of this network in that it associates with MYC as well as with the family of MAD proteins : MAD 1 , MXI 1 , MAD 3 and MAD 4 . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| Targeted deletion of the S phase specific Myc antagonist Mad 3 sensitizes neuronal and lymphoid cells to radiation induced apoptosis . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| N Myc , Max , Mad 1 , and Mad 3 immunoreactivity was detected in the epidermis and the epithelium of both anagen and telogen hair follicles . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| Complexes formed by Max with Mxi 1 , Mad 3 , or Mad 4 were enriched in nuclear foci , whereas complexes formed with Myc were more uniformly distributed in the nucleoplasm . ^^^ The distinct subcellular locations and the differences between the efficiencies of dimerization with Max indicate that Mad 3 and Mad 4 are likely to modulate transcription activation by Myc at least in part through distinct mechanisms . . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| Isolation and comparative expression analysis of the Myc regulatory proteins Mad 1 , Mad 3 , and Mnt during Xenopus development . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| Mad family members , including Mad 1 , Mxi 1 , Mad 3 , Mad 4 , Mnt , and Mga , function in part as antagonists of Myc oncoproteins . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| MAX serves as a cofactor for DNA binding by the various members of this network , which include the MYC family of oncoproteins and a group of putative MYC antagonists that include MNT , MXD 1 4 ( formerly MAD 1 , MXI 1 , MAD 3 and MAD 4 ) and MGA . ^^^ |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|