| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| These findings indicate that MDS transformed to Burkitt ' s ALL through multiple cytogenetic evolutions , the final event of which seems to be overexpression of the c myc gene . . ^^^ |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| We have studied six cases ( five AML and one MDS ) with MYC containing dmin . ^^^ These results exclude MYC as the target gene and indicate that overexpression of C8FW may be the functionally important consequence of 8q24 amplicons in AML and MDS . . ^^^ |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| The AMEX method of fixation permitted the serial study of c myc expression in bone marrow ( BM ) biopsies obtained from 6 patients with acute myelogenous leukaemia ( AML ) and one with myelodysplastic syndrome ( MDS ) during therapy with various cytotoxic and bioactive agents . ^^^ |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| A total of 42 samples from 31 de novo AML patients , 10 samples from eight cases of post MDS AML and 85 samples from 67 MDS patients were analysed with probes for ACHE , BCHE , c MYC , MDR 1 and globin control . ^^^ |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| We evaluated levels of apoptosis and of apoptosis related oncoproteins ( c Myc , which enhances , and Bcl 2 , which diminishes apoptosis ) expressed within CD34+ and CD 34 marrow cell populations of MDS patients ( n = 24 ) to determine their potential roles in the abnormal hematopoiesis of this disorder . ^^^ Correlated with these findings , the ratio of expression of c Myc to Bcl 2 oncoproteins among CD34+ cells was significantly increased for MDS patients compared to those from normal and AML individuals ( mean values : 1 . 6 > 1 . 2 > 0 . 9 ) . ^^^ These findings are consistent with the hypothesis that altered balance between cell death ( eg , c Myc ) and cell survival ( eg , Bcl 2 ) programs were associated with the increased degrees of apoptosis present in MDS hematopoietic precursors and may contribute to the ineffective hematopoiesis in this disorder , in contrast to decreased apoptosis and enhanced leukemic cell survival in AML . . ^^^ |
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| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| In all but two MDS patients , the observed c myc oncoprotein score values did not differ statistically from those found in the controls . ^^^ Our data suggest that c myc activation may be seen in all cases of MDS in overt ANLL phase , and also in some RAEB patients a few weeks before diagnosis of overt ANLL . ^^^ The possible prognostic value of c myc activation in MDS patients remains to be clarified . . ^^^ |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| Of 119 genes residing in this region , seven genes 14 3 3epsilon ( YWHAE ) , HIC 1 , ROX / MNT ( a helix loop helix transcription factor and member of the MYC / MAX superfamily ) , KIAA 0399 , UBE2G1 ( ubiquitin ligase ) , ALOX 15 , and MINK encode proteins with potential links to cancer . ^^^ |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01106 and P62258 |
Pubmed |
SVM Score :0.0 |
| NA |
|