| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| Since GSK 3 beta exhibits an identical site specificity to GSK 3 alpha with respect to phosphorylation of the proto oncogene / transcription factors c jun and c myc , it is likely that the Drosophila zw3sgg protein kinase has a similar specificity for such transcription factors which may underlie the pleiotropic phenotypes observed when the Drosophila homologue is mutationally inactivated . . ^^^ |
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| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| The APC / beta catenin pathway is highly regulated and includes players such as GSK 3 beta , CBP , Groucho , Axin , Conductin , and TCF . c MYC and cyclin D 1 were recently identified as a key transcriptional targets of this pathway and additional targets are likely to emerge . ^^^ |
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| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| Consequently , the GSK 3 beta protein level increased , resulting in the destabilization of beta catenin and the subsequent suppression of cyclin D 1 and c myc expression . ^^^ |
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| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| Conversely , overexpression of GSK 3 alpha or GSK 3 beta enhances Thr 58 phosphorylation and ubiquitination of c Myc . ^^^ |
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| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| Notable among the signaling proteins regulated by GSK3beta are the many transcription factors , including activator protein 1 , cyclic AMP response element binding protein , heat shock factor 1 , nuclear factor of activated T cells , Myc , beta catenin , CCAAT / enhancer binding protein , and NFkappaB . ^^^ |
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| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| In this study , we aim to investigate the expression pattern of various components of the Wnt pathway including b catenin and its partners LEF 1 / TCF 4 , GSK 3beta and their nuclear target genes such as c myc and cyclin D 1 during mouse brain development . ^^^ |
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| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| Curcumin reduced the expression of cell cycle regulators , cyclin D 1 and c Myc proteins , which are both degraded by activated GSK 3beta . ^^^ |
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| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| Treatment of CML cell lines and mouse Bcr Abl+ 32D cells with either Jak 2 short interfering RNA or Jak 2 kinase inhibitor AG 490 inhibited pTyr Gab 2 and pSer Akt formation , inhibited the activation of nuclear factor kappaB , and caused the activation of GSK 3beta , leading to the reduction of c Myc . ^^^ |
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| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| APC , in conjunction with AXIN and GSK 3beta , forms a complex necessary for the degradation of beta catenin , thereby preventing beta catenin / T cell factor interaction and alteration of growth controlling genes such as c MYC and cyclin D 1 . ^^^ |
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| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| Murine ES cells express elevated levels of Myc and following LIF withdrawal , Myc mRNA levels collapse and Myc protein becomes phosphorylated on threonine 58 ( T 58 ) , triggering its GSK3beta dependent degradation . ^^^ |
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| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| Myc family transcription factors are destabilized by phosphorylation of a conserved amino terminal GSK 3beta motif . ^^^ In proliferating cerebellar granule neuron precursors ( CGNPs ) , Sonic hedgehog signaling induces N myc expression , and N myc protein is stabilized by insulin like growth factor mediated suppression of GSK 3beta . ^^^ We report that phosphorylation induced turnover of endogenous N myc protein in CGNPs increases during mitosis , due to increased priming phosphorylation of N myc for GSK 3beta . ^^^ |
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| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| A TRAIL receptor dependent synthetic lethal relationship between MYC activation and GSK3beta / FBW7 loss of function . ^^^ Here , by screening a kinase directed library of small inhibitory RNAs , we identify glycogen synthase kinase 3beta ( GSK3beta ) as a gene whose inactivation potentiates TNF related apoptosis inducing ligand death receptor mediated apoptosis specifically in MYC overexpressing cells . ^^^ Small inhibitory RNA induced silencing of GSK3beta prevents phosphorylation of MYC on T 58 , thereby inhibiting recognition of MYC by the E 3 ubiquitin ligase component FBW 7 . ^^^ Attenuating the GSK3beta FBW 7 axis results in stabilization of MYC , up regulation of surface levels of the TNF related apoptosis inducing ligand death receptor 5 , and potentiation of death receptor 5 induced apoptosis in vitro and in vivo . ^^^ These results identify GSK3beta and FBW 7 as potential cancer therapeutic targets and MYC as a critical substrate in the GSK3beta survival signaling pathway . ^^^ |
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| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| Myc destabilization occurs in response to phosphorylation by GSK 3beta . ^^^ During mitosis in cerebellar neural precursors , levels of N Myc primed for phosphorylation by GSK 3beta increase , due to cdk 1 complex activity towards N Myc . ^^^ |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|