| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Reciprocal regulation of adipogenesis by Myc and C / EBP alpha . 3T3 L 1 adipoblasts that express large amounts of c Myc can not terminally differentiate , raising the possibility that Myc inhibits the expression of genes that promote adipogenesis . ^^^ Expression of Myc prohibited the normal induction of C / EBP alpha and prevented adipogenesis . ^^^ Enforced expression of C / EBP alpha overcame the Myc induced block to differentiation . ^^^ These results provide a molecular basis for the regulation of adipogenesis and implicate Myc and C / EBP alpha as pivotal controlling elements . . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Adhesion of hepatocytes to the EHS gel for the same period of time dramatically alters this program : it arrests growth and inhibits AP 1 DNA binding activity and the expression of c jun , junB , and c myc mRNAs , but , in addition , it restores C / EBP alpha mRNA and protein as well as C / EBP alpha and C / EBP beta DNA binding activities to the abundant levels present in freshly isolated hepatocytes . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Two differentiation specific genes containing Inr , the C / EBP alpha and albumin genes , are repressed through their basal promoters by c Myc , but are activated by the related B HLH LZ factor , USF . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Reciprocal regulation of gadd 45 by C / EBP alpha and c Myc . ^^^ We also found that c Myc antagonized C / EBP alpha mediated transactivation of gadd 45 . ^^^ Analysis of systematically altered forms of C / EBP alpha revealed that c Myc antagonism targeted the antimitotic , transcriptional activation domain of C / EBP alpha . ^^^ In addition , we localized the regulatory sequences in the gadd 45 promoter that are required for c Myc antagonism of C / EBP alpha transactivation . ^^^ In addition , our findings reveal that the reciprocal relation between C / EBP alpha and c Myc in 3T3 L 1 cells includes antagonistic transcriptional control of a growth arrest associated gene . . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Mutation of either results in loss of C / EBP alpha inhibition of E2F and down regulation of c Myc , but only mutation of the basic region results in loss of physical interaction with E2F . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Of interest , the expression of cyclin genes ( A 2 , B , D 1 , and E ) , hepatocyte nuclear factor genes ( HNF 1alpha , beta , 3beta , and 4alpha ) , and oncogenic markers ( P 53 , c myc , beta catenin , N ras , and gankyrin ) were up regulated , while the expression of C / EBP alpha was down regulated in a zfMcl 1a mediated anti apoptotic process of the liver . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Various transcription factors , including C / EBP , GCN 4 and members of the Fos , Jun and Myc families have been shown to form highly specific complexes via alpha helical structures referred to as leucine zippers . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| The protein sequence deduced from the open reading frame of a human placental cDNA encoding a cAMP responsive enhancer ( CRE ) binding protein ( CREB 327 ) has structural features characteristic of several other transcriptional transactivator proteins including jun , fos , C / EBP , myc , and CRE BP 1 . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| The opaque 2 protein contains a domain similar to the leucine zipper motif identified in DNA binding proteins of animal protooncogenes such as fos , jun and myc , and in the transcriptional activators GCN 4 and C / EBP . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Conformational energy analysis of the leucine repeat regions of C / EBP , GCN 4 , and the proteins of the myc , jun , and fos oncogenes . ^^^ It has been recently proposed that certain DNA binding proteins ( including C / EBP , GCN 4 and the myc , jun , and fos oncogene proteins ) share a common structural motif based on helix promoting regions containing heptad repeat sequences of leucines . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Transcription control and differentiation : the HLH family , c myc and C / EBP . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| A 30 amino acid segment of C / EBP , a newly discovered enhancer binding protein , shares notable sequence similarity with a segment of the cellular Myc transforming protein . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| The non AUG initiated form of the c Myc protein , c Myc 1 , strongly and specifically activates transcription of the C / EBP sequences within the EFII enhancer element of the Rous sarcoma virus long terminal repeat . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| This proximal promoter region of the mouse HO 1 gene contains several sequence elements that are not only conserved in both the rat and human HO 1 genes but also resemble consensus binding sites of various transcription factors including AP 1 , AP 4 , C / EBP and c Myc : Max / USF . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| These substrates include transcription factors that are regulated by MAP kinase phosphorylation ( e . g . , Elk 1 , c Myc , c Jun , c Fos , and C / EBP beta ) . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| A novel function for Myc : inhibition of C / EBP dependent gene activation . ^^^ We find that 5 Myc dramatically down regulates the expression of myelomonocytic specific genes , such as the chicken mim 1 and lysozyme genes , both of which are known targets for C / EBP transcription factors . ^^^ We present evidence that Myc downregulates these genes by inhibiting the function of C / EBP transcription factors . ^^^ Detailed examination of the inhibitory mechanism shows that amino terminal sequences of 5 Myc , but not its DNA binding domain , are required for the suppression of C / EBP dependent transactivation . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| This induction of PEPCK expression by cAMP occurred in the presence of sustained levels of CCAAT / enhancer binding protein ( C / EBP ) alpha delta mRNAs , and was accompanied by an increase in the rate of transcription and mRNA content of C / EBP beta gene , and a decrease in the expression of c myc , in the absence of c fos expression . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Instead , several putative transcriptional factor binding sites for C / EBP , PEA 3 , AP 2 , NF Y , Sp 1 , c Myc , GATA 1 , AP 1 , 5 Myb , and CREB were detected . ^^^ Functional analysis of promoter activity of the 5 ' flanking region of cyclin D 2 suggested that the region 1 , 100 to 805 including C / EBP , PEA 3 , AP 2 , NF Y , c Myc , and Sp 1 may have a major positive regulatory activity for expression of cyclin D2 . . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| These include AP 1 , AP 2 , NF kB , C / EBP , c Myc and a metal responding element identified in the promoter region , and two Sp 1 elements in intron 1 . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Lack of TNFR 2 had little effect on NF kappaB and STAT 3 binding , and no effect in interleukin 6 production after PH , but caused a delay in AP 1 and C / EBP binding and in the expression of c jun and c myc messenger RNA ( mRNA ) . ^^^ Inhibition of AP 1 and C / EBP binding and in the expression of c jun and c myc mRNA in the first 4 hours after PH , as well as the apparent lack of Fos in AP 1 complexes , had no effect on the timing or extent of DNA replication . . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Farther from the +1start , various putative cis elements including AP 1 , AP 4 , NF kappaB , STAT , CREB , C / EBP and c Myc were observed . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| In 32Dcl3 cells overexpressing c myc that do not differentiate by means of G CSF , induction of C / EBP epsilon is completely abrogated . ^^^ These data show that C / EBP epsilon constitutes a rate limiting step in G CSF regulated granulocyte differentiation and that c myc antagonizes G CSF induced myeloid differentiation , at least partly by suppressing induction of C / EBP epsilon . ( Blood . 2001 ; 98 : 897 905 ) . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Gel shift analysis revealed three different profile groups : 1 ) transcription factors that responded to both radiation ( 2 Gy ) and epidermal growth factor ( EGF ) ( CREB , Egr , Ets , and Stat 3 ) ; 2 ) factors that responded to radiation , but not EGF ( C / EBP and Stat 1 ) ; and 3 ) those that did not respond significantly to either radiation or EGF ( AP 1 and Myc ) . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| The promoter region lacks a TATA box but contains potential binding sites for the transcriptional factors including SP 1 , E2F , c Myc , C / EBP and NFkappaB . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Downregulation of cytochromes P 450 in growth stimulated rat hepatocytes : role of c Myc induction and impaired C / EBP binding to DNA . ^^^ The N terminal c Myc domain added to control nuclear extracts prevented C / EBP DNA binding . ^^^ CONCLUSIONS : EGF overexpresses c Myc , decreases C / EBP binding to DNA and downregulates CYPs . ^^^ We suggest that c Myc may form inactive complexes with C / EBPs , thus decreasing C / EBP mediated CYP transactivation . . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Cell transformation by the 5 myc oncogene abrogates c Myc / Max mediated suppression of a C / EBP beta dependent lipocalin gene . ^^^ The promoter region contains consensus binding sites for the transcriptional regulators Myc and C / EBP beta . ^^^ Transcriptional activation of Q 83 is principally dependent on C / EBP beta , but is blocked in normal cells by the endogenous c Myc / Max / Mad transcription factor network . ^^^ In 5 myc transformed cells , high level expression of the 5 Myc protein and formation of highly stable 5 Myc / Max heterodimers leads to abrogation of Q 83 gene suppression and activation by C / EBP beta . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| Interferon regulatory factor 7 ( IRF 7 ) and IRF 5 negatively regulated P 1 activity . c Myc and C / EBP family members positively regulated P 2 . ^^^ |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|