| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.93193247 |
| Here , we found that JNK selectively interacted with , and phosphorylated , c Myc at Ser 62 and Ser 71 as confirmed with phospho c Myc specific antibodies . 0.93193247^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| The mechanism of glucose deprivation induced activation of Lyn kinase ( Lyn ) , c Jun N terminal kinase 1 ( JNK 1 ) and increased expression of basic fibroblast growth factor ( bFGF ) and c Myc was investigated in MCF 7 / ADR adriamycin resistant human breast carcinoma cells . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| FAK ( F397Y ) , which encodes a dominant negative mutant of FAK , attenuated the shear stress induced kinase activity of Myc epitope tagged ERK 2 and hemagglutinin epitope tagged JNK 1 . ^^^ DeltamSos 1 , encoding a dominant negative mutant of Sos in which the guanine nucleotide exchange domain has been deleted , also attenuated shear stress activation of Myc ERK 2 and hemagglutinin JNK 1 . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| In association with cell death , c Myc impaired TNF induced activation of phospholipase A 2 , JNK protein kinase and cell survival signaling associated NF kappaB transcription factor complex . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| To determine the possible role of the BCR / ABL oncoprotein SH 3 domain in BCR / ABL dependent leukemogenesis , we studied the biologic properties of a BCR / ABL SH 3 deletion mutant ( delta SH 3 BCR / ABL ) constitutively expressed in murine hematopoietic cells . delta SH 3 BCR / ABL was able to activate known BCR / ABL dependent downstream effector molecules such as RAS , PI 3kinase , MAPK , JNK , MYC , JUN , STATs , and BCL 2 . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| Shear stress induction of the hemagglutinin ( HA ) epitope tagged HA JNK 1 and the Myc epitope tagged Myc ERK 2 was significantly attenuated by 5 src ( K295R ) and c src ( K295R ) , the kinase defective mutants ofv src and c src , respectively . ^^^ HA JNK 1 and Myc ERK 2 were activated by c src ( F 527 ) , a constitutively activated form of p60src , and the activation was abolished by RasN 17 , a dominant negative mutant of p2lras . ^^^ In contrast , although HA JNK 1 and Myc ERK 2 were also activated by RasL 61 , an activated form of p21ras , the activation was not affected by 5 src ( K295R ) . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| No changes were observed , however , in the DNA binding activity of ATF 2 and Elk 1 , transcription factors involved in both the JNK and p 38 pathways of MAP signal transduction , nor in the gene expression of c myc . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| Differential role of the JNK and p 38 MAPK pathway in c Myc and s Myc mediated apoptosis . ^^^ Here we showed that s Myc mediated apoptosis triggered by UV was not inhibited by the inactive form mutant JNK ( APF ) , though c Myc mediated apoptosis was . ^^^ Moreover , we found that JNK did not affect the transactivation activity of s Myc , but stimulated that of c Myc . ^^^ Our results indicate that s Myc does not require the JNK signaling unlike c Myc during UV triggered apoptosis , but the MKK6 / p38MAPK pathway might regulate common apoptotic machinery for both s Myc and c Myc upstream of caspase . . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| Differential roles of JNK and Smad 2 signaling pathways in the inhibition of c Myc induced cell death by TGF beta . ^^^ Furthermore , overexpression of the constitutively activated mutant RacL61F37A , which selectively stimulates JNK cascade but not G 1 cell cycle progression or actin polymerization , was sufficient to prevent apoptosis induced by c Myc . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| Recently , glucose deprivation induced oxidative stress has been shown to cause cytotoxicity , activation of signal transduction ( i . e . , ERK 1 , ERK 2 , JNK , and Lyn kinase ) , and increased expression of genes associated with malignancy ( i . e . , bFGF and c Myc ) in MCF 7 / ADR human breast cancer cells . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| Here we describe a protein , JLP ( c Jun NH 2 terminal kinase associated leucine zipper protein ) , which acts as a scaffolding protein to bring together Max and c Myc along with JNK ( c Jun NH 2 terminal kinase ) and p38MAPK , as well as their upstream kinases MKK 4 ( MAPK kinase 4 ) and MEKK 3 ( MAPK kinase kinase 3 ) . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| However , increased cytoplasmic expression of MAPK / ERK P , SAPK / JNK P , p 38 P , CREB P , Elk 1 P , c Myc P , ATF 2 P and c Jun P occurred in the region bordering the infarct core ( penumbra ) at 4 h following reperfusion . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| The platelet derived growth factor controls c myc expression through a JNK and AP 1 dependent signaling pathway . ^^^ Here we show that JNK is required for the induction of c myc expression by PDGF . ^^^ These findings suggest the existence of a novel biochemical route linking tyrosine kinase receptors , such as those for PDGF , and c myc expression through JNK activation of AP 1 transcription factors . ^^^ They also provide a novel potential mechanism by which both JNK and Jun proteins may exert either their proliferative or apoptotic potential by stimulating the expression of the c myc proto oncogene . . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To investigate the possible involvement of c Myc and ceramide c Jun N terminal kinase ( JNK ) pathway in 10 ray induced apoptotic cell death of MOLT 4 cells . ^^^ MATERIALS AND METHODS : The expressions of c Myc protein and c myc mRNA after 10 irradiation were analysed by Western blotting and RT PCR between radiosensitive MOLT 4 and radioresistant variant Rh 1a cells with less JNK activation than the parental cells . ^^^ The effect of a JNK activator anisomycin or c Myc inhibitor peptides ( Int H 1 S6A , F8A ) on the amount of c Myc protein and on the induction of apoptosis was investigated , respectively . ^^^ Anisomycin rapidly induced JNK activation and a subsequent decrease of c Myc protein , causing cell death in MOLT 4 cells . ^^^ On the other hand , Rh 1a cells were more resistant to anisomycin than parental MOLT 4 cells , showing less JNK activation and a delayed decrease of c Myc protein . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| Jun NH 2 kinase ( JNK ) contributes to the regulation of c Myc protein stability . ^^^ This region of c Myc shares homology with the delta domain of c Jun , which is required for JNK association and subsequent targeting of c Jun for ubiquitination under non stressed growth conditions . ^^^ Here we demonstrate that JNK associates with , and mediates , c Myc ubiquitination and degradation . ^^^ Addition of JNK increased the degree of c Myc ubiquitination in in vitro ubiquitination reactions . ^^^ Increased c Myc stability following MEKK1 / JNK stimuli is abolished upon mutation within the delta like domain of c Myc ( aa 166 181 ) , as well as deletion of aa 127 189 . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| RESULTS : SP 600125 at 10 microM drastically inhibited JNK phosphorylation but had little effect on CD 40 mediated p 38 phosphorylation and expression of the NF kappaB dependent genes c Myc and bcl xL . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| Survival signals provided by CD 40 and interleukin 10 ( IL 10 ) together reversed the growth inhibition induced by the JNK inhibitor . c Myc protein levels were reduced in the presence of both SP 600125 and JNK specific siRNA , and CD 40 ligation restored c Myc levels . ^^^ Thus , JNK may act via c Myc and Egr 1 , which were shown to be important for B lymphoma survival and growth . . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined the involvement of Akt / PKB and its upstream kinase , PDK 1 and whether JNK activation correlated with human and rat VSMC apoptosis induced by staurosporine and by c myc , respectively . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| Abl tyrosine kinase regulates a Rac / JNK and a Rac / Nox pathway for DNA synthesis and Myc expression induced by growth factors . ^^^ Finally , we found that Myc is an important target of this signaling cascade : Myc induction was sensitive to small inhibitors of JNK and Nox activities and forced expression of Myc overcame the G 1 block induced by dominant interfering mutants of mitogen activated protein kinase kinase 4 ( MKK 4 ) and Nox 2 activating subunit . ^^^ We concluded that cytoplasmic Abl operates on a Rac / JNK and a Rac / Nox pathway for PDGF induced Myc induction and DNA synthesis . . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| JNK 1 and P 38 kinase , two stress activated kinases , play key roles relaying stress signals leading to cell death through cyclin D 1 and c Myc . ^^^ Cell death mediated by the overactivation of JNK 1 and P 38 kinase was cyclin D 1 and c Myc independent . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| To understand the mechanisms of this different sensitivity , we examined a panel of genes involved in apoptosis : ornithine decarboxylase , c Myc and p 53 protein levels progressively decreased while JNK 1 , caspase 8 and 3 activities persistently increased in c 4 cells undergoing apoptosis . ^^^ Distinct time related events in c1c7 cells were the transient activations of JNK 1 and caspase 8 followed by the accumulation of ODC and c Myc proteins . ^^^ |
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| Interacting proteins: P45983 and P01106 |
Pubmed |
SVM Score :0.0 |
| Major nodes in the up regulated network were IL 6 , AGT , MYC , and A2M , those in the down regulated network were IL 2 , 4 , and 10 , MAPK 8 , SOCS 1 , and CREB 1 . ^^^ |
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