| Interacting proteins: P42704 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42704 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42704 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42704 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42704 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42704 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42704 and P01106 |
Pubmed |
SVM Score :0.0 |
| By using gene array analysis , we demonstrate that c jun , NF kappa B , c myc , and tumor necrosis factor receptor expression is gp 130 dependent . ^^^ |
|
| Interacting proteins: P42704 and P01106 |
Pubmed |
SVM Score :0.0 |
| In particular , hIL4R constructs with a truncation of the recently described gp 130 box1 from P 242 to K 264 , or a deletion of the acidic region between S 330 and S 365 , fail to stimulate growth or to mediate the inhibition of apoptosis . hIL4R bearing a point mutation within the gp 130 box1 ( P242S ) is defective for growth stimulation but still signals the transient inhibition of apoptotic cell death and the induction of c myc RNA . ^^^ |
|
| Interacting proteins: P42704 and P01106 |
Pubmed |
SVM Score :0.0 |
| The assay is based on the interaction between biotinylated human CNTF , soluble gp 130 , and soluble myc tagged CNTF receptor captured on a microtiter plate via an antibody against the myc epitope tag . ^^^ |
|
| Interacting proteins: P42704 and P01106 |
Pubmed |
SVM Score :0.0 |
| By using chimeric receptors consisting of the extracellular domain of growth hormone receptor and the transmembrane and cytoplasmic domain of gp 130 with progressive C terminal truncations , we showed that the membrane proximal 133 , but not 108 , amino acids of gp 130 could generate the signals for growth arrest , macrophage differentiation , down regulation of c myc and c myb , induction of junB and IRF 1 and Stat 3 activation . ^^^ |
|
| Interacting proteins: P42704 and P01106 |
Pubmed |
SVM Score :0.0 |
| STAT 3 is required for the gp 130 mediated full activation of the c myc gene . ^^^ We show that STAT 3 mostly mediates the rapid activation of the c myc gene upon stimulation of the interleukin ( IL ) 6 receptor or gp 130 , a signal transducing subunit of the receptor complexes for the IL 6 cytokine family . ^^^ We show that STAT 3 binds to a region overlapping with the E2F site in the c myc promoter and this site is critical for the c myc gene promoter driven transcriptional activation by IL 6 or gp 130 signals . ^^^ |
|
| Interacting proteins: P42704 and P01106 |
Pubmed |
SVM Score :0.0 |
| These results indicate that Pim family proteins play crucial roles in gp 130 mediated cell proliferation and explain the synergy between Pim and c Myc proteins in cell proliferation and lymphomagenesis . . ^^^ |
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