| Interacting proteins: P40692 and P01106 |
Pubmed |
SVM Score :0.0 |
| The objective was to determine efficacy of the combined treatment and to correlate response with constitutive levels of TP 53 , WAF 1 , and hMLH 1 proteins , as well as with mRNA levels of the apoptosis related genes survivin , BNIP 3 , and MYC . ^^^ |
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| Interacting proteins: P40692 and P01106 |
Pubmed |
SVM Score :0.0 |
| The gastrointestinal carcinogenesis is suggested to be associated with the decrease of total genomic DNA methylation ; hypomethylation of certain specific oncogenes such as c myc , c Ha ras , c fos and alpha fetoprotein ; and hypermethylation of the promoter of some tumor suppressor genes containing p 16 ( INK4A ) , E cadherin and hMLH 1 genes . ^^^ |
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| Interacting proteins: P40692 and P01106 |
Pubmed |
SVM Score :0.0 |
| A novel MLH 1 mutation harbored as a germ line aberration by a young woman of an HNPCC like family and exhibited by a CML patient when occurring prior to the initiation of the blast phase concomitant with a c MYC amplification . ^^^ |
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| Interacting proteins: P40692 and P01106 |
Pubmed |
SVM Score :0.0 |
| The expression patterns for 8 of 15 genes have been reported previously in prostate tissues ( TGFbeta 3 , TGFBR 3 , IGFII , IGFBP 2 , VEGF , FGF 7 , ERBB 3 , MYC ) , but those of seven genes are reported here for the first time ( MLH 1 , CYP1B1 , RFC 4 , EPHB 3 , MGST 1 , BTEB 2 , MLP ) . ^^^ |
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| Interacting proteins: P40692 and P01106 |
Pubmed |
SVM Score :0.0 |
| Interactions of the DNA mismatch repair proteins MLH 1 and MSH 2 with c MYC and MAX . ^^^ As well as known partners of MLH 1 such as PMS 1 , MLH 3 and MBD 4 , we identified the carboxy terminus of the human c MYC proto oncogene as an interacting sequence . ^^^ We demonstrate , both in vitro by yeast two hybrid and GST fusion pull down experiments , as well as in vivo by coimmunoprecipitation from human tumour cell extracts , that MLH 1 interacts with the c MYC protein . ^^^ |
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| Interacting proteins: P40692 and P01106 |
Pubmed |
SVM Score :0.0 |
| Myc down regulation sensitizes melanoma cells to radiotherapy by inhibiting MLH 1 and MSH 2 mismatch repair proteins . ^^^ CONCLUSIONS : Data herein reported show that Myc down regulation lowers the apoptotic threshold in melanoma cells by inhibiting MLH 1 and MSH 2 proteins , thus increasing cell sensitivity to gamma radiation in a p 53 independent fashion . ^^^ |
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| Interacting proteins: P40692 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40692 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40692 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40692 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40692 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40692 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40692 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|