Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P01106 and P38398	Pubmed	SVM Score :1.0501572
BRCA 1 binds c Myc and inhibits its transcriptional and transforming activity in cells . c Myc , a proto oncogene that is implicated in tumorigenesis , embryonic development and apoptosis , can physically associate with BRCA 1 . 1.0501572^^^ Endogenous interactions between BRCA 1 and c Myc were also observed . 1.0383932^^^ We have found that BRCA 1 interacts with c Myc in yeast , in in vitro assays and in mammalian cells . 0.64278496^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :1.128269
In addition , BRCA 1 associates with c Myc and inhibits the binding activity of c Myc to the hTERT promoter . 1.128269^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.51093742
To examine whether C MYC ( MYC ) , a transforming oncogene associated with genetic instability , contributes to multistep tumor progression in BRCA 1 associated breast cancer , we have analyzed tumors from women with hereditary BRCA 1 mutated and sporadic breast cancers . 0.51093742^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.61283283
Furthermore , we show that BRCA 1 and c Myc form a complex on the psoriasin promoter and that BRCA 1 mediated repression of psoriasin is dependent on functional c Myc . 0.61283283^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
Fourteen cases of DCIS and 11 of DCIS with minimal invasion were analysed for mRNA levels of beta actin , EGFR , c cerbB 2 , MTS 1 , k ras , RB , BRCA 1 , cyclin E , and c myc genes . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
In contrast to Bcl XL , SF blocked ADR induced increases in c Myc and inhibited the expression of p21WAF1 / CIP1 and of the BRCA 1 protein in MDA MB 453 cells . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
Forty tumors , 29 linked to BRCA 1 and 11 linked to BRCA 2 , were examined for mutational alterations in P 53 , K RAS , ERBB 2 , C MYC , and AKT 2 . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
Wild type BRCA 1 protein binds to a number of cellular proteins , including DNA repair protein Rad 51 , tumor suppressor p 53 , RNA polymerase 2 holoenzyme , RNA helicase A , CtBP interacting protein , c myc , BRCA 1 associated RING domain protein ( BARD 1 ) , BRCA 2 protein , etc . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
To understand the mechanism underlying the inhibition of proliferation by estradiol , we examined the expression of several growth related endogenous genes . c Myc protooncogene expression was strongly inhibited by treatment with estradiol as was expression of BRCA 1 and BRCA 2 genes , which is in agreement with their mitogenic dependent expression , while expression of beta actin , a housekeeping gene , was not affected by hormone treatment . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
Recently described interactions between the CTD and other cellular proteins , including YY 1 , AP 2 , BRCA 1 , TFII 1 , and Miz 1 , suggest levels of regulatory complexity beyond Max in controlling DNA recognition by c Myc . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
Developmental analysis of eyes from these Mx c myc mice revealed irregular development of the iris and ciliary body at embryonic day 15 . 5 and the closed angle at 1 week of age . ^^^ Leaky exogenous c myc expression was detected in cornea , iris , lens , and retina from the Mx c myc mice by reverse transcriptase polymerase chain reaction and Southern blot analysis . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
In addition , BRCA 1 is linked to a number of genes involved in transcriptional regulation , including CtIP , c Myc , the RNA holoenzyme complex , and the histone deacetylase complex . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
BRCA 1 contains several functional domains that interact directly or indirectly with a variety of molecules , including tumor suppressors ( p 53 , RB , BRCA 2 and ATM ) , oncogenes ( c Myc , casein kinase 2 and E2F ) , DNA damage repair proteins ( RAD 50 and RAD 51 ) , cell cycle regulators ( cyclins and cyclin dependent kinases ) , transcriptional activators and repressors ( RNA polymerase 2 , RHA , histone deacetylase complex and CtIP ) and others . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
Other genes , including c fos , c myc , thymidine kinase , proliferating cell nuclear antigen , BRCA 1 , BRCA 2 , and Cox 1 , were not significantly affected by TF 2 . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
A novel tricomplex of BRCA 1 , Nmi , and c Myc inhibits c Myc induced human telomerase reverse transcriptase gene ( hTERT ) promoter activity in breast cancer . ^^^ Because c Myc can activate transcription of the human telomerase reverse transcriptase gene ( hTERT ) , we addressed the role of BRCA 1 and Nmi in modulating c Myc induced hTERT promoter activity . ^^^ Although Nmi or BRCA 1 alone had no effect on c Myc induced hTERT promoter activity , BRCA 1 together with Nmi significantly inhibited this c Myc induced hTERT promoter activity ( approximately 75 % inhibition ) . ^^^ Two mutated forms of BRCA 1 , a missense ( A1708E ) and a nonsense ( Y1853X ) that have been identified in familial breast cancers , associated with Nmi and c Myc but failed to suppress c Myc induced hTERT promoter activity . ^^^ These results demonstrate a novel pathogenic mechanism whereby mutations in BRCA 1 , via a novel transcription factor complex containing BRCA 1 , c Myc , and Nmi , impair inhibition of c Myc induced hTERT promoter activity , which allows sustained activation of telomerase , a key enzyme in carcinogenesis . . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
The objective was to determine the DNA integrity of the BRCA 1 tumor suppressor gene and the c myc proto oncogene after PTX . ^^^ Single primer polymerase chain reactions ( PCR ) were carried out on lysed sperm targeting either BRCA 1 exon 11 or c myc exon 1 . ^^^ CONCLUSIONS : The data showed PTX pretreatment protected BRCA 1 but not c myc suggesting that PTX did not equally protect different cell genes . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
A significant positive correlation was noted between BRCA 1 and c myc ( P = 0 . 012 ) . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
E 6 and E 7 also antagonized the ability of BRCA 1 to inhibit c Myc E box mediated transactivation and human telomerase reverse transcriptase promoter activity , in a manner dependent upon the zinc finger domains . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
Chromatin immunoprecipitation analysis revealed that CHD 8 was present at known CTCF target sites , such as the differentially methylated region ( DMR ) of H 19 , the locus control region of beta globin , and the promoter region of BRCA 1 and c myc genes . ^^^ Further , the lack of CHD 8 affected CpG methylation and histone acetylation around the CTCF binding sites , adjacent to heterochromatin , of BRCA 1 and c myc genes . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
BRCA 1 regulated genes associated with breast tumorigenesis included the estrogen responsive genes MYC and cyclin D 1 , which are overexpressed in many breast tumors ; STAT 1 and JAK 1 , key components of the cytokine signal transduction pathway ; the extracellular matrix protein laminin 3A ; ID 4 , an inhibitor of DNA binding transcriptional activators , which in turn negatively regulates BRCA 1 expression ; and the prohormone stanniocalcin , expression of which is lost in breast tumor cells . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
In keeping with its antagonism of Myc , HIF 1alpha also downregulates Myc activated genes such as hTERT and BRCA 1 . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
ERBB 2 and MYC alterations in BRCA 1 and BRCA 2 associated cancers . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
ERBB 2 , TBX 2 , RPS6KB1 , and MYC alterations in breast tissues of BRCA 1 and BRCA 2 mutation carriers . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
In contrast , c MYC amplification was present in 18 . 2 , 62 . 5 , and 12 . 5 % of BRCA 1 , BRCA 2 , and non BRCA1 / 2 IDCs , respectively , and 31 % in the control group . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
We found that an exogenous BRCA 1 gene strongly inhibited telomerase enzymatic activity in human prostate and breast cancer cell lines and caused telomere shortening in cell lines expressing wild type BRCA 1 ( wtBRCA 1 ) but not a tumor associated mutant BRCA 1 ( T300G ) . wtBRCA 1 inhibited the expression of the catalytic subunit ( telomerase reverse transcriptase [ TERT ] ) but had no effect on the expression of a subset of other components of the telomerase holoenzyme or on the expression of c Myc , a transcriptional activator of TERT . ^^^ However , endogenous BRCA 1 associated and partially colocalized with c Myc ; exogenous wtBRCA 1 strongly suppressed TERT promoter activity in various cell lines . ^^^ Suppression of TERT promoter and c Myc activity required the amino terminus of BRCA 1 but not the carboxyl terminus . ^^^ Finally , endogenous BRCA 1 and c Myc were detected on transfected mouse and human TERT promoter segments in vivo . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
We report on a phylogenetic study comprising 53 genera sequenced for four nuclear genes , GHR , BRCA 1 , RAG 1 , and c myc , totaling up to 6400 nucleotides . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
A review is presented of the expression and role of the BRCA 1 and 2 genes , p 53 , amplification of Her2 / neu , PIK3CA , AKT 2 , K ras , c myc , BRCA 1 , p 53 , p 16 , and p 27 in ovarian cancer . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
Ubiquitin mediated proteolysis plays a central role in controlling intracellular levels of essential regulatory molecules such as p 53 , cyclins , myc , BRCA 1 , HIF 1alpha , etc . ^^^
Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P38398	Pubmed	SVM Score :0.0
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