| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.51840294 |
| We have used these data to test whether the strong synergistic interaction between Pim 1 and c myc can be utilized to gain access to Pim 1 compensatory pathways . 0.51840294^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.75066059 |
| The pim 1 oncogene is regulated by hematopoietic cytokine receptors , encodes a serine / threonine protein kinase , and cooperates with c myc in lymphoid cell transformation . 0.75066059^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.72165707 |
| This module includes the Pim 1 kinase , a gene known to cooperate with Myc in tumorigenesis , and defines a subset of human , `` Myc like ' ' human cancers . 0.72165707^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Insertion of the coding sequences in exons 2 and 3 into the appropriate expression vectors yielded detectable c myc protein in Escherichia coli lacking the Lon protease and in Saccharomyces cerevisiae upon induction . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| The myc nuclear oncoprotein , for example , can collaborate with cytoplasmic oncoproteins such as ras , raf , bcl 2 , pim 1 and 5 abl , as well as with nuclear products such as bmi 1 or the tumour suppressor p 53 . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Three proviral integration sites were identified ; near c myc , N myc and pim 1 . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| In approximately one third of cases , the Mo + PyF 101 Mo MuLV proviruses were found at common sites for wild type Mo MuLV induced tumors ( c myc , pvt 1 , and pim 1 ) , indicating that this virus is capable of performing insertional activation in T lymphoid cells . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| E mu N and E mu L myc cooperate with E mu pim 1 to generate lymphoid tumors at high frequency in double transgenic mice . ^^^ Complementation of the E mu N and L myc transgenic mice by breeding with E mu pim 1 animals leads to much more rapid development and a dramatically higher incidence of lymphoid malignancies , but the lineage specificity prescribed by the E mu N and L myc transgenes is maintained . ^^^ Whereas c myc / pim 1 animals develop pre B cell leukemia prenatally , the mean latency period for N myc / pim 1 and L myc / pim 1 mice is 36 and 94 days respectively . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Among 18 thymic leukemia cell lines which have been established from spontaneous thymic lymphomas in AKR mice as well as in bone marrow chimeras which were constructed by transplanting allogeneic bone marrow cells into irradiated AKR mice , three proviral integration sites were identified ; near c myc , N myc and pim 1 loci . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Carcinogen induced lymphomagenesis in pim 1 transgenic mice : dose dependence and involvement of myc and ras . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Rearrangements of the Pim 1 , c myc , and p 53 genes in Friend helper virus induced mouse erythroleukemias . ^^^ Interestingly , genetic alterations were also detected at two loci , c myc and Pim 1 , previously described as common provirus integration regions in T lymphoid leukemias . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Both showed rearrangements of c myc and Pim 1 genes that appeared to result from integration of recombinant mink cytopathic focus forming ( MCF ) proviruses but failed to reveal evidence for activation of ras oncogenes , either by DNA transfection experiments or by hybridization of DNA to specific oligonucleotide probes . ^^^ Some alteration in c myc and Pim 1 genes were also found in MNU induced tumors , but , mainly , these involved integration of ecotropic like rather than recombinant MCF viruses . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Pim 1 and c myc genes commonly rearranged in other virus induced thymic lymphoma showed rearrangement in only a few lymphomas . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Expression of the proto oncogenes c myc , p 53 , c jun , pim 1 , lck , c syn , c raf and N ras were detected in Hodgkin ' s disease derived cell lines and in normal hematopoietic cells . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Concanavalin A stimulated spleen cells , representative of replicating T cells , expressed c myc , c abl , and Pim 1 , suggesting that the products of these proto oncogenes are involved in T cell proliferation . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| This has become clear from our studies with pim 1 and c myc transgenic mice . ^^^ In all tumors induced by MuLV in pim 1 transgenic mice , either the c myc or the N myc gene was activated by proviral insertion . ^^^ This shows that pim 1 and myc synergize efficiently in both B and T cell lymphomagenesis . pim 1 transgenic mice are also highly sensitive to tumor induction by N ethyl N nitrosourea ( ENU ) and therefore represent an excellent in vivo model system to test the oncogenic potential of chemical compounds . . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Previous studies of 21 highly lymphomatous AKXD recombinant inbred mouse strains demonstrated correlations between lymphoma type , the somatic proviral DNA content of the lymphoma , and the frequency of virally induced rearrangements in eight common sites of viral integration ( Myc , Pim 1 , Pvt 1 , Mlvi 1 , Mlvi 2 , Fis 1 , Myb , and Evi 1 ) . ^^^ No rearrangements were detected in the Fis 1 , Mlvi 2 , and Myb loci , whereas rearrangements were detected in the Mlvi 1 , Myc , Pim 1 , Pvt 1 , and Evi 1 loci . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Second , a majority of tumors induced by Mo+Pywt M MuLV ( and also wild type , M MuLV ) showed proviral integrations near one or more of the cellular c myc , pim 1 , or pvt 1 loci . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Rearrangement of c myc , pim 1 and Mlvi 1 and trisomy of chromosome 15 in MCF and Moloney MuLV induced murine T cell leukemias . ^^^ Provirus insertion near the c myc , pim 1 or Mlvi 1 genes occurred in 7 out of 59 virally induced T cell leukemias . ^^^ Provirus insertion near c myc , pim 1 or Mlvi 1 occurred both in diploid lymphomas and in tumors with trisomy 15 . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Southern analysis of tumour DNA revealed that 2 / 30 spontaneous tumours and 2 / 52 MNU induced tumours contained alterations in the c myc gene while 5 / 29 spontaneous tumours and 6 / 56 MNU induced tumours contained alterations in the Pim 1 gene . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| This location demonstrates that Dsi 1 is different from 16 of the known proto oncogenes ( c abl , c erbA c erbB , c ets 1 , c ets 2 , c fes , c fos , c myb , c myc , c raf , A raf , c Ha ras , c Ki ras , N ras , c sis , and c src ) and 12 cellular regions of tumor associated integrations in retrovirus induced tumors ( c erbB , Fis 1 , int 1 , int 2 , Mis 1 / pvt 1 , Mlvi 1 , Mlvi 2 , c mos , c myb , c myc , Pim 1 , and c Ha ras ) . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Clonal selections occurring during the progression of Moloney murine leukemia virus ( MuLV ) induced T cell lymphomas in mice were examined in primary and transplanted tumors by monitoring various molecular markers : proviral integration patterns , MuLV insertions near c myc and pim 1 , and rearrangements of the immunoglobulin heavy chain and beta chain T cell receptor genes . ^^^ Moloney MuLV frequently induced oligoclonal tumors with proviral insertions near c myc or pim 1 in the independent clones . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| By analogy with other cellular oncogenes that are similarly activated ( e . g . , myc , myb , erbB ) it is possible that pim 1 may also be involved in some human tumors . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| LGF dependent cells are non tumorigenic or poorly tumorigenic , do not clone in soft agar , have no detectable rearrangements in the c myc or Pim 1 region and possess near diploid or pseudodiploid karyotypes without evidence for trisomy of chromosomes nos . 15 or 17 . ^^^ Thus in 10 ray induced lymphomagenesis an autocrine , LGF dependent phase precedes the progressed phase characterized by rearrangements in the myc and / or Pim 1 regions as well as by many chromosomal aberrations visible in the karyotype . . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Rearrangements were detected in the Myc , Pvt 1 , Pim 1 , Mlvi 1 , Mlvi 2 , and Fis 1 loci , but not in the Myb locus . ^^^ Alterations in the Myc and Pim 1 loci , although occurring predominantly in T cell lymphomas , were occasionally detected in other types of lymphoma . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Our studies have revealed four common DNA regions for provirus insertion in these tumors ( Mlvi 1 , Mlvi 2 , Mlvi 3 and c Myc ) , while studies from other laboratories have revealed two additional ones ( pvt 1 / mis 1 and pim 1 ) . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| In 20 % of the early T cell lymphomas , proviral integrations were detected both near c myc and the pim 1 gene . ^^^ They comprise both lymphomas in which integration near c myc and pim 1 occurred in separate tumor cell populations , as well as tumors in which proviral integration near c myc and pim 1 occurred in the same cell clone . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Southern blot analysis of tumor DNA from MMuLV infected transgenic mice revealed a proviral insertion at the c myc gene in 26 % ( 9 / 35 ) of tumors , at the pim 1 gene in 6 % ( 2 / 35 ) and at the pim 2 ( recently renamed tic 1 ) gene in 23 % ( 8 / 35 ) . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Role of bcl 2 , pim 1 , c myc and p 53 genes in selection processes of thymocytes ] . ^^^ There are independent signaling pathways which transmit apoptotic signals in thymocytes . c Myc and p 53 proteins participate in the apoptosis induction , whereas Bcl 2 and Pim 1 proteins inhibit complex apoptotic machinery . . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| The membrane proximal region is responsible for induction of c myc and pim 1 , and is indispensable for GM CSF dependent proliferation of mouse BaF 3 transfectants . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| These were examined for virus induced rearrangements of the c myc , flvi 2 ( bmi 1 ) , fit 1 , and pim 1 loci , for T cell receptor ( TCR ) gene rearrangements , and for the presence of env recombinant FeLV ( FeLV B ) . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Deletions at amino acid 517 ( beta 517 ) and 626 ( beta 626 ) induced c myc and pim 1 , but no induction of c fos and c jun was observed . ^^^ Thus , there are at least two distinct regions within the cytoplasmic domain of beta c that are responsible for different signals , i . e . a membrane proximal region of approximately 60 amino acid residues upstream of Glu 517 is essential for induction of c myc and pim 1 , and a distal region of approximately 140 amino acid residues ( between Leu 626 and Ser 763 ) is required for activation of Ras , Raf 1 , MAP kinase and p 70 S6 kinase , as well as induction of c fos and c jun . . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| We find that cell growth is correlated with prolonged increases in the cell levels of c myc , pim 1 , and cyclin D 2 mRNAs , but not with changes in either immediate early genes or mitogen activated protein kinase phosphorylation . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Fli 1 , p 53 , and Evi 1 were found to be rearranged in 72 % , 23 % , and 18 % of the tumors , respectively , whereas no DNA alteration were detected for c myc , c myb , Pim 1 , Evi 2 , and EpoR genes . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Insertion near the c myc , N myc or pim 1 gene was observed in 42 % of the induced tumors , indicating that each of these genes may collaborate with 5 abl in lymphomagenesis . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| From these data , we suggest that the induction of pim 1 and c myc is independently regulated . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Zinc finger protein GFI 1 cooperates with myc and pim 1 in T cell lymphomagenesis by reducing the requirements for IL 2 . ^^^ The clonality of lymphomas that originate in myc / pim 1 bitransgenic mice due to synergistic action of both oncogenes indicates the requirement of additional events for progression to full malignancy . ^^^ To isolate genes that cooperate with both myc and pim 1 , we have used provirus tagging with E mu L myc / pim 1 double transgenic mice . ^^^ Our data suggest that gfi 1 is a proto oncogene cooperation with both myc and pim 1 genes in T cell lymphomagenesis . . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Analysis of c myc , pim 1 , and pal 1 showed that these loci were occupied by proviruses in some cases but at similar frequencies in p 53 wild type and null mice . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| In a previous study Emu pim 1 / Emu L myc bitransgenic mice had been inoculated neonatally with MoMuLV supF virus . ^^^ The retroviral infection led to acceleration of lymphomagenesis indicating the proviral activation of further oncogenes cooperating with myc and pim 1 in tumour development . ^^^ Together with three other previously described Moloney integration clusters all responsible for enhanced gfi 1 expression the number of tumours from infected double transgenic Emu L myc / Emu pim 1 transgenic mice with retrovirally activated gfi 1 added up to 53 % underscoring the role of GFI 1 as an effective collaborator for MYC and PIM 1 in the process of lymphomagenesis . . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Pim 1 , a protooncogene product , induced tumor in the combination with MYC . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Elevated pim 1 and c myc proto oncogene induction in B lymphocytes from BLV infected cows with persistent B lymphocytosis . ^^^ We analyzed the expression of two proto oncogenes , pim 1 and c myc , proto oncogenes deregulated in some human B cell leukemias and lymphomas , in peripheral blood mononuclear leukocytes ( PBML ) from BLV infected PL cows . ^^^ Results demonstrate that pim 1 and c myc mRNA levels are elevated in unfractionated stimulated PBML from a sample of PL cows naturally infected with BLV . ^^^ These results suggest that pim 1 and c myc are upregulated in B lymphocytes from BLV infected PL cows and that deregulation of proto oncogene expression is not limited to completely transformed cells , but can also characterize a naturally occurring , pre neoplastic lymphocytic state . . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| This article describes the significance of the mouse transgenic model in elucidation of the role and the oncogenic potential of such genes as N ras , pim 1 , bcl 2 , myc and p 53 . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Alterations in pim 1 and c myc expression associated with sodium butyrate induced growth factor dependency in autonomous rat Nb 2 lymphoma cells . ^^^ In the present study , the relation of NaBT induced growth arrest to the cell cycle was examined using flow cytometry , and the effect of PRL on expression of the immediate early proto oncogenes , pim 1 and c myc , in NaBT pretreated cultures was evaluated . ^^^ In other experiments , NaBT treatment significantly reduced the steady state levels of pim 1 and c myc mRNA . ^^^ Results from mRNA stability studies suggest that the observed increases in expression of pim 1 and c myc most likely do not reflect increased stability of the transcripts . ^^^ The results indicate that NaBT induced differentiation in autonomous Nb 2 SFJCD1 causes growth arrest of the cells in the G 1 phase of the cell cycle and reduces the basal levels of pim 1 and c myc mRNAs . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| The Gfi 1 repressor allows interleukin 2 ( IL 2 ) dependent T cells to escape G 1 arrest induced by IL 2 withdrawal in culture and collaborates with c myc and pim 1 for the induction of retrovirus induced lymphomas in animals . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Characterization of pal 1 , a common proviral insertion site in murine leukemia virus induced lymphomas of c myc and Pim 1 transgenic mice . ^^^ Insertional mutagenesis with Moloney murine leukemia virus ( MoMLV ) in c myc and Pim 1 transgenic mice permits the identification of oncogenes that collaborate with the transgenes in lymphomagenesis . ^^^ The eis 1 / pal 1 / gfi 1 / evi 5 locus serves as a target for MoMLV proviral insertions in pre B cell lymphomas of Emu myc transgenic mice ( 20 % ) and in T cell lymphomas of H 2K myc ( 75 % ) and Emu pim 1 ( 93 % ) transgenic mice . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Propagation of tumors induced by Moloney murine leukemia virus ( M MuLV ) in E mu Pim 1 or H 2 K myc transgenic mice by transplantation to syngeneic hosts permitted proviral tagging of ' progression ' genes . ^^^ Transplantation of such primary lymphomas allows for a further expansion of tumor cell clones carrying a proviral insertion near Frat 1 , resulting in detectable Frat 1 rearrangements in 17 % of the transplanted E mu Pim 1 tumors and 30 % of the transplanted H 2 K myc tumors , respectively . ^^^ Tumor cell lines with high expression of Myc and Pim 1 acquired an additional selective advantage in vivo upon infection with a Frat 1 IRES lacZ retrovirus , thus underscoring the role of Frat 1 in tumor progression , and the ability of Frat 1 to collaborate with Pim 1 and Myc in lymphomagenesis . . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Presently we show that a highly truncated Epo receptor form that retains box 1 , yet lacks the conserved box 2 domain ( and all Tyr ( P ) sites ) nonetheless effectively promotes mitogenesis , survival , and Myc and Pim 1 expression . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| A panel of thymomas induced by intrathymic injection of Mo MuLV , Abelson murine leukemia virus ( A MuLV ) , or the bcr abl / M virus was analyzed for proviral integration near c myc , N myc , Pim 1 , and Mlvi 1 loci that are frequently occupied by provirus in Mo MuLV induced T cell lymphomas , and for integration near Ahi 1 that is often occupied in A MuLV / M induced pre B cell lymphoma . ^^^ The bcr abl / M induced tumors also showed recurring proviral integration near c myc , Pim 1 and Mlvi 1 , albeit at a lower frequency than seen in the Mo MuLV tumors . ^^^ These observations suggest that recurring proviral insertion in c myc , Pim 1 , Mlvi 1 , and Ahi 1 may provide a selective advantage for bcr abl / M transformed T lymphoid cells . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Pim 1 kinase stimulates c Myc mediated death signaling upstream of caspase 3 ( CPP 32 ) like protease activation . ^^^ Pim 1 oncoprotein is a serine / threonine kinase that can closely cooperate with c Myc in lymphomagenesis , as does Bcl 2 . ^^^ In this study , therefore , we examined the effect of Pim 1 expression on c Myc mediated apoptosis of Rat 1 fibroblasts triggered by serum deprivation . ^^^ Our results showed that , rather than inhibiting apoptosis , Pim 1 expression stimulated c Myc mediated apoptosis in Rat 1 fibroblasts . ^^^ Pim 1 stimulated c Myc mediated apoptosis through an enhancement of the c Myc mediated activation of caspase 3 ( CPP 32 ) like proteases , since the suppression of this activity by a specific caspase inhibitor abolished the apoptosis stimulation by Pim 1 . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| The Pim 1 gene was targeted by retroviral insertions in 48 % of accelerated lymphomas whereas less than 5 % contained activated c Myc and none contained activated Pim 2 . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| The results show that gfi 1 can act with low activity as a dominant oncogene when overexpressed but also demonstrate that it is most efficient only in the presence of a cooperative partner protein as for example Pim 1 or L Myc . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| In contrast to suppression of Stat 5 , proliferative responses to IL 2 were augmented in IL 4 cultured cells , and activation of proliferative pathways leading to activation of mitogen activated protein kinases , induction of expression of Myc , Fos , Pim 1 , and cyclin D 3 , and decreased levels of the cyclin dependent kinase inhibitor p 27 were intact . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Interferon alpha activates multiple STAT proteins and upregulates proliferation associated IL 2Ralpha , c myc , and pim 1 genes in human T cells . ^^^ We have analyzed the expression of IL 2Ralpha , c myc , and pim 1 genes in anti CD 3 activated human T lymphocytes . ^^^ Treatment of T lymphocytes with IFN alpha , IL 2 , IL 12 , and IL 15 upregulated IL 2Ralpha , c myc , and pim 1 gene expression . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Southern blot analysis revealed rearrangements in c myc , Fli 1 , Pim 1 , and Spi 1 / PU . 1 genes in 20 , 10 , 3 . 3 , and 3 . 3 % of the tumors tested , respectively . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| We have applied proviral tagging in compound mutant Emu myc / Pim1 / / Pim2 / mice to identify genes that can complement for the loss of Pim 1 and Pim 2 and , therefore , are able to synergize with c myc in lymphomagenesis . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Implications for the Pim 1 mediated activation of the c Myc signaling pathway . ^^^ Pim 1 is unique in that it closely cooperates with c Myc not only in oncogenesis , but also in apoptosis induction . ^^^ Here we provide several lines of evidence that Cdc25A cell cycle phosphatase , a direct transcriptional target for c Myc , is a substrate for Pim 1 kinase and functions as an effector for Pim 1 . ^^^ Our results indicate that Cdc25A might be a key molecule that links Pim 1 and c Myc and that also ties Pim 1 mediated mitogenic signals to cell cycle machinery . . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| The relationship between c Myb and the serine threonine kinase pim 1 , its immediate activator , is discussed , together with the possibility that c Myb , like pim 1 , may be able to synergize with c Myc to induce tumors . . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Among the gene products encoded by these polysome associated mRNAs were immediate early transcription factors , kinases , and phosphatases of the mitogen activated protein kinase pathways and several protooncogenes , including c myc and Pim 1 . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Synergistic roles for Pim 1 and c Myc in STAT 3 mediated cell cycle progression and antiapoptosis . ^^^ Constitutive expression of Pim 1 together with c myc , another STAT 3 target , fully compensated for loss of the STAT 3 mediated cell cycle progression , antiapoptosis , and bcl 2 expression . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Protooncogene , pim 1 , has been reported to be a predisposition for lymphomagenesis along with myc , and its protein product , Pim 1 , has been shown to be a serine / threonine protein kinase , whose activity is involved in proliferation and differentiation of blood cells . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| To gain further insight into the relationship of Runx 2 to other lymphomagenic pathways , we tested the effect of combining the CD 2 Runx2 transgene either with a Pim 1 transgene ( E ( mu ) Pim 1 ) or with the p 53 null genotype , as each of these displays independent synergy with Myc . ^^^ Analysis of known Moloney MLV target genes in these lymphomas showed a high frequency of rearrangement at c Myc or N Myc ( 82 % ) , and a significant number at Pim 1 or Pim 2 ( 23 % ) , and at Pal1 / Gfi1 ( 18 % ) . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Here we report that an aberrant hypermutation activity targets multiple loci , including the proto oncogenes PIM 1 , MYC , RhoH / TTF ( ARHH ) and PAX 5 , in more than 50 % of diffuse large cell lymphomas ( DLCLs ) , which are tumours derived from germinal centres . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| PMP 1 induced greater expression of Pim 1 , c Myc , and cyclin D 2 than did either an IL 3 receptor agonist or c Mpl receptor agonist alone . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| We applied retroviral insertional mutagenesis in Myc transgenic ( E mu Myc ) mice lacking expression of Pim 1 and Pim 2 to search for genes that can substitute for Pim 1 and Pim 2 in lymphomagenesis . ^^^ We determined the chromosomal positions of 477 retroviral insertion sites ( RISs ) derived from 38 tumors from E mu Myc Pim 1 ( / ) Pim 2 ( / ) mice and 27 tumors from E mu Myc control mice using the Ensembl and Celera annotated mouse genome databases . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| At the molecular level , STAT 3 proteins function as transcriptional activators and up regulate several growth promoting genes such as myc , pim 1 , or cyclin D 1 . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Oncogenes CMYC , BCL 2 and PIM 1 were upregulated more frequently in the blastoid variant than in common MCL . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| In these tumors , the somatic hypermutation ( SHM ) process that normally targets immunoglobulin 5 ( IgV ) genes in B cells appears to misfire and causes mutations in the 5 ' sequences of multiple proto oncogenes , including PIM 1 , PAX 5 , RhoH / TTF , and c MYC . ^^^ Overall , PIM 1 was mutated in 5 of 39 ( 12 . 8 % ) , PAX 5 in 8 of 39 ( 20 . 5 % ) , RhoH / TTF in 9 of 39 ( 23 . 1 % ) , and c MYC in 7 of 27 ( 25 . 9 % ) AIDS NHL cases . ^^^ In addition , a number of mutations in PIM 1 and c MYC were found to affect coding exons , leading to amino acid substitutions with likely functional consequences . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| The Myc phenotype of the M 20 mutant was a single Mendelian recessive trait , stable for nine generations , and nonallelic to a previously identified M 161 pmi mutant . ^^^ Our results indicate that this new mutant shares similar physiological characteristics with the M 161 pmi mutant , but has a more suppressive Myc phenotype response . . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Transcripts identified by the assay included those that facilitate tissue healing ( early growth response gene ( egr ) 1 ) , regulate inflammation ( interleukin ( IL ) 6 , tristetraproline ( ttp ) ) , cell growth ( c myc , cytokine inducible SH 2 containing protein ( cish ) 3 ) , apoptosis ( T cell death associated protein ( tdag ) 51 , pim 1 ) and DNA repair ( ephrin type A receptor 2 ( ephA 2 ) ) . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Soluble factors released from roots of the pre mycorrhizal infection ( pmi ) myc ( ) tomato mutant M 161 were analyzed and compared with normal wild type released factors . ^^^ |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| We have addressed whether aberrant ongoing hypermutation can be detected in the proto oncogenes PIM 1 , c MYC , RhoH / TTF , PAX 5 , and the tumor suppressor gene CD 95 in primary central nervous system lymphomas ( PCNSLs ) derived from immunocompetent HIV negative patients . ^^^ Nine of 10 PCNSLs analyzed harbored somatic mutations in the PIM 1 , c MYC , RhoH / TTF , and PAX 5 genes , but not in the CD 95 gene , with 8 tumors carrying alterations in at least 2 of these genes . ^^^ In summary , our data demonstrate aberrant somatic hypermutations at high frequency in the PIM 1 , PAX 5 , RhoH / TTF , and c MYC genes in most PCNSLs . ^^^ |
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| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Exposure of a PRL independent subline , Nb 2 SFJCD1 , to sodium butyrate ( NaBT ) causes transient reversal of their growth factor independent proliferation in association with constitutive expression of protooncogenes pim 1 and c myc . ^^^ |
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| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| PCLBCLs leg showed increased expression of genes associated with cell proliferation ; the proto oncogenes Pim 1 , Pim 2 , and c Myc ; and the transcription factors Mum1 / IRF4 and Oct 2 . ^^^ |
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| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| The protooncogene Pim 1 cooperates with c Myc and enhances the transcriptional activity of c Myb in hematopoietic cells , suggesting that Pim 1 is involved in cell cycle regulation . ^^^ |
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| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| To understand the target specificity of SHM in AID expressing T lymphomas , we sequenced six oncogenes ( c myc , pim 1 , p 53 , atm , tgfbr 2 , and k ras ) and two genes ( cd 4 and cd 5 ) that are actively transcribed in T lymphomas . ^^^ SHM was found only in c myc , pim 1 , cd 4 , and cd 5 , which share the E 47 binding motif in the enhancer / promoter . ^^^ |
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| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| The incidence of PIM 1 , PAX 5 , RhoH / TTF , and c MYC mutations in tumour biopsy specimens from 32 HCV infected B cell NHL patients was analysed to determine whether the extent of aberrant SHM among these patients differed from that previously reported for HCV negative B cell NHL patients . ^^^ Mutation of PIM 1 , PAX 5 , RhoH / TTF , and c MYC was detected in 4 ( 13 % ) , 5 ( 16 % ) , 4 ( 13 % ) , and 4 ( 13 % ) of 32 samples , respectively . ^^^ |
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| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| We found retroviral integrations in c myc and Pim 1 as already reported but we also identified for the first time Notch 1 as a RadLV common integration site . ^^^ |
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| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| We have found that the cellular levels of c Myc were elevated in the Pim 1 and Pim 2 transfectants under these conditions . ^^^ |
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| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| Here , we show that while individual cases of primary CNS lymphomas may be classified as germinal center B cell , activated B cell , or type 3 large B cell lymphoma , brain lymphomas are distinguished from nodal large B cell lymphomas by high expression of regulators of the unfolded protein response ( UPR ) signaling pathway , by the oncogenes c Myc and Pim 1 , and by distinct regulators of apoptosis . ^^^ |
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| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| AG 490 inhibited the growth of HTLV 1 infected T cell lines and primary ATL cells by inducing G 1 cell cycle arrest mediated by altering the expression of cyclin D 2 , Cdk 4 , p 53 , p 21 , Pim 1 and c Myc , and by apoptosis mediated by the reduced expression of c IAP 2 , XIAP , survivin and Bcl 2 . ^^^ |
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| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| To assess whether aberrant SHM plays a role in the molecular pathogenesis of Hodgkin lymphoma ( HL ) , we investigated microdissected neoplastic cells of nodular lymphocyte predominant HL ( NLPHL ; n = 10 ) and classic HL ( cHL ; n = 9 ) for the presence of mutations in the 5 ' sequences of 4 previously identified aberrant SHM targets ( PIM 1 , PAX 5 , RhoH / TTF , c MYC ) . ^^^ |
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| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36776 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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