| Interacting proteins: P29590 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29590 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29590 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29590 and P01106 |
Pubmed |
SVM Score :0.66715204 |
| PML interacts with Myc , and Myc target gene expression is altered in PML null fibroblasts . c myc is a well known proto oncogene encoding for a transcription factor that needs to be tightly regulated in order to preserve cell homeostasis . 0.66715204^^^ Consistently , we show that Myc partially localizes to the NB and physically interacts with PML , and that this localization depends on Myc expression levels . 0.59940632^^^ |
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| Interacting proteins: P29590 and P01106 |
Pubmed |
SVM Score :0.0 |
| The results show that : ( 1 ) As2O3 triggers relatively specific NB 4 cell apoptosis at micromolar concentration , as proved by morphology , histogramic related nuclear DNA contents , and DNA gel eletrophoresis . ( 2 ) As2O3 does not influence bax , bcl 10 , c myc , and p 53 gene expression , but downregulates bcl 2 gene expression at both mRNA and protein levels . ( 3 ) As2O3 induces a significant modulation of the PML staining pattern in NB 4 cells and HL 60 cells . ^^^ |
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| Interacting proteins: P29590 and P01106 |
Pubmed |
SVM Score :0.0 |
| As2O3 induced PML ( promyelocytic leukemia ) protein degradation but did not modulate expression of cell cycle related proteins , including c myc , retinoblastoma protein , cyclin dependent kinase 4 , cyclin D 1 , and p 53 , or expression of differentiation related antigens . ^^^ |
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| Interacting proteins: P29590 and P01106 |
Pubmed |
SVM Score :0.0 |
| In keeping with the role of PML in transcriptional repression , pRB also promoted PML dependent transcriptional repression by the c Myc antagonist Mad 1 . ^^^ |
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| Interacting proteins: P29590 and P01106 |
Pubmed |
SVM Score :0.0 |
| Importantly , however , several findings provide evidence for an unanticipated relationship between c Myc and PML nuclear bodies , which is enhanced under conditions of proteasome inhibition . ^^^ This work provides a comprehensive study of c Myc distribution and also presents the first evidence of a relationship between turnover of this oncoprotein and PML nuclear bodies , known to break down in certain cancers . . ^^^ Myc localization within the nucleus : evidence for association with the PML nuclear body . ^^^ Evidence of Max concentration within PML bodies is shown both with and without proteasome inhibition , strengthening the relationship between PML bodies and Myc / Max . ^^^ Some accumulation of Myc and Max in nucleoli upon proteasome inhibition is also observed , although co localization of ubiquitin was only seen with PML bodies . ^^^ |
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| Interacting proteins: P29590 and P01106 |
Pubmed |
SVM Score :0.0 |
| We focus on paradigmatic examples such as c myc and PML , as well as on more recent findings from our laboratory concerning the role of NPM in tumorigenesis . . ^^^ |
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