| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.58428194 |
| Affinity chromatography confirmed that YY 1 associates with c Myc but not with Max . 0.58428194^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.63639946 |
| Direct association of YY 1 with c Myc and the E box binding protein in regulation of glycophorin gene expression . 0.63639946^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.67246898 |
| YY 1 has previously been shown to interact with several transcription factors including Myc . 0.67246898^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :1.0523115 |
| Immunoprecipitation assays showed that in HHV 6 infected cells association of c Myc with YY 1 was decreased and that of Max with c Myc was increased , whereas association of Mad with Max appeared to be decreased . 1.0523115^^^ Transcriptional down regulation of CXC chemokine receptor 4 induced by impaired association of transcription regulator YY 1 with c Myc in human herpesvirus 6 infected cells . 0.65219036^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| Bifunctional transcriptional properties of YY 1 in regulating muscle actin and c myc gene expression during myogenesis . ^^^ The c myc and skeletal alpha actin gene promoters contain YY 1 binding sites thought to act either as positive or negative cis acting elements . ^^^ Through manipulating the intracellular level of YY 1 by treating primary myoblasts with bromodeoxyuridine ( BrdU ) , which inhibited myogenesis and increased the YY 1 protein content , or by transfecting YY 1 cDNA expression vector , we show that it can simultaneously inhibit and activate expression of the skeletal alpha actin and c myc genes , respectively . ^^^ We propose that the high level of YY 1 in proliferating myoblasts might serve to maintain c myc expression and suppress muscle actin expression , which can then be gradually reversed by downregulating YY 1 activity toward myogenesis . . ^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| In cotransfection experiments , YY 1 is a strong activator of transcription from c myc promoter based reporters . ^^^ Furthermore , in murine erythroleukemia cells , overexpressed YY 1 causes increased levels of c myc mRNA initiated from both major transcription initiation sites of the endogenous c myc gene . . ^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| YY 1 and c Myc associate in vivo in a manner that depends on c Myc levels . ^^^ The c Myc oncoprotein has previously been shown to associate with transcription regulator YY 1 and to inhibit its activity . ^^^ We show herein that endogenous c Myc and YY 1 associate in vivo and that changes in c Myc levels , which accompany mitogenic stimulation or differentiation of cultured cells , affect the ratio of free to c Myc associated YY 1 . ^^^ We have also investigated the mechanism by which association with c Myc inhibits YY 1 ' s ability to regulate transcription . c Myc does not block binding of YY 1 to DNA . ^^^ However , protein association studies suggest that c Myc interferes with the ability of YY 1 to contact basal transcription proteins TATA binding protein and TFIIB . . ^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| YY 1 can inhibit c Myc function through a mechanism requiring DNA binding of YY 1 but neither its transactivation domain nor direct interaction with c Myc . ^^^ The proto oncoprotein c Myc and the multifunctional transcriptional regulator YY 1 have been shown previously to interact directly in a manner that excludes Max from the complex ( Shrivastava et al . , 1993 ) . ^^^ As binding to Max is necessary for all known c Myc activities we have analysed the influence of YY 1 on c Myc function . ^^^ We demonstrate that YY 1 is a potent inhibitor of c Myc transforming activity . ^^^ The region in YY 1 required for inhibition corresponds to a functional DNA binding domain and is distinct from the domains necessary for direct binding to c Myc . ^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| A variety of functions of C MYC , the product of c myc , are attributed to protein protein interactions with various cellular factors including Max , YY 1 , p 107 , Bin 1 and TBP . ^^^ Max and YY 1 bind to the C terminal region of C MYC , while p 107 , Bin 1 and TBP bind to the N terminal region covering myc boxes . ^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| The c Myc oncoprotein is important in control of cellular proliferation and differentiation , while Yin Yang 1 ( YY 1 ) has been shown to control the expression of a number of cellular and viral genes . ^^^ In this study , we show that USF / c Myc up regulates , while YY 1 down regulates the promoter activity of CXCR 4 , a coreceptor for T cell tropic HIV 1 entry . ^^^ Mutation of the E box abolished USF / c Myc mediated up regulation of CXCR 4 promoter activity , and mutation of the YY 1 binding site was associated with unresponsiveness to YY 1 mediated inhibition . ^^^ These data suggest that USF / c Myc and YY 1 may play an important role in the HIV 1 replicative cycle , by modulating both the viral fusion / entry process and viral expression . . ^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| Recently described interactions between the CTD and other cellular proteins , including YY 1 , AP 2 , BRCA 1 , TFII 1 , and Miz 1 , suggest levels of regulatory complexity beyond Max in controlling DNA recognition by c Myc . ^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| Analysis of 5 ' flanking regions revealed binding sequences of several putative transcription factors such as Sp 1 , Pit 1a , c Jun , c Myc and YY 1 . ^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| A number of interaction partners of Myc have been identified , such as Max , p 107 , TBP , YY 1 , Miz 1 , AP 2 and Nmi . ^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| The results show that Blimp 1 represses the c myc promoter by an active mechanism that is independent of the adjacently bound activator YY 1 . ^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that YY 1 , acting as a transcription factor binding to its site on the promoter , or through protein protein interaction with AP 2 , may be part of a regulatory network including key cell cycle regulators such as c Myc and Rb in controlling growth and differentiation regulated gene expression . . ^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| Involvement of YY 1 and its correlation with c myc in NDEA induced hepatocarcinogenesis , its prevention by d limonene . ^^^ However , along with our earlier information about c myc with the present study , clearly indicated the involvement of YY 1 in NDEA induced hepatocarcinogenesis and d limonene mediated chemoprevention which might be regulated by c myc oncoprotein . . ^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| Accordingly , YY 1 does not interfere with the regulation of immediate early genes involved in the TGF beta growth inhibitory response , the cell cycle inhibitors p 15 and p 21 , and the proto oncogene c myc . ^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| Whereas CHK had no significant effects on the expression of YY 1 , c Myc , Max , and other YY 1 binding proteins , CHK was found to modulate the YY1 / c Myc association . ^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| Analysis of the regulation of YY 1 localization in vitro demonstrated that polymerized gamma actin sequestered EGFP YY 1 in the cytoplasm and that YY 1 activation of c myc promoter activity was inhibited by LIM kinase , which increases actin polymerization . ^^^ |
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| Interacting proteins: P25490 and P01106 |
Pubmed |
SVM Score :0.0 |
| Molecular mechanisms that have been investigated include YY 1 mediated downregulation of p 53 activity , interference with poly ADP ribose polymerase , alteration in c myc and nuclear factor kappa B ( NF kappaB ) expression , regulation of death genes and gene products , and differential YY 1 binding in the presence of inflammatory mediators . ^^^ |
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